KEGG   ORTHOLOGY: K01655
Entry
K01655                      KO                                     
Symbol
LYS21, LYS20
Name
homocitrate synthase [EC:2.3.3.14]
Pathway
map00300  Lysine biosynthesis
map00620  Pyruvate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Reaction
R00271  acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K01655  LYS21, LYS20; homocitrate synthase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K01655  LYS21, LYS20; homocitrate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14  homocitrate synthase
     K01655  LYS21, LYS20; homocitrate synthase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K01655
Other DBs
COG: COG0119
GO: 0004410
Genes
SCE: YDL131W(LYS21) YDL182W(LYS20)
SEUB: DI49_0897
SPAO: SPAR_D00610 SPAR_D01060
AGO: AGOS_ADR107W
ERC: Ecym_8045
KLA: KLLA0_E23695g KLLA0_F05489g
KMX: KLMA_10771(LYS21) KLMA_60493(LYS21)
LTH: KLTH0E12848g KLTH0H02486g
VPO: Kpol_2000p11
ZRO: ZYRO0A13222g ZYRO0C09416g
CGR: 2889536(GVI51_J06259) 2889949(LYS21)
NCS: NCAS_0A13800(NCAS0A13800) NCAS_0E03640(NCAS0E03640)
NDI: NDAI_0A02240(NDAI0A02240) NDAI_0A02990(NDAI0A02990)
TPF: TPHA_0P00840(TPHA0P00840)
TBL: TBLA_0A05940(TBLA0A05940)
TGB: HG536_0C05440 HG536_0H02920
TDL: TDEL_0B02910(TDEL0B02910) TDEL_0H01490(TDEL0H01490)
KAF: KAFR_0B01160(KAFR0B01160)
KNG: KNAG_0B02880(KNAG0B02880) KNAG_0C04080(KNAG0C04080)
ZMK: HG535_0A05750 HG535_0G01540
SLUD: SCDLUD_000290 SCDLUD_002024
DHA: DEHA2D13222g DEHA2F08514g
PIC: PICST_28701(LYS21) PICST_89386(LYS22)
PGU: PGUG_01126 PGUG_01480
SPAA: SPAPADRAFT_136285(LYS22) SPAPADRAFT_58182
LEL: PVL30_001014(LYS1_1) PVL30_001780(LYS21)
LBG: 92207809(LODBEIA_P26130) 92209571(LODBEIA_P43750)
CAL: CAALFM_C104730CA(LYS21) CAALFM_C204460WA(LYS22)
CTP: CTRG_01594 CTRG_04686
COT: CORT_0A12020 CORT_0B06650
CDU: CD36_04470 CD36_19070
CTEN: 18246775(LYS22) 18248055(LYS21)
CLU: CLUG_01219 CLUG_05100
CLUS: A9F13_03g01375 A9F13_06g00154
CAUR: CJI96_0001452 CJI96_0002255
PPA: PAS_chr1-1_0313 PAS_chr1-4_0421
PKZ: C5L36_0C01170 C5L36_0D05690
BNN: FOA43_003157(LYS21)
BBRX: BRETT_000905(LYS21_1) BRETT_003395(LYS21_2)
OPA: HPODL_02806 HPODL_04767
YLI: 2907696(YALI2_E00847g)
SLB: AWJ20_418(LYS21)
NCR: NCU05526(lys-5)
NTE: NEUTE1DRAFT68872(NEUTE1DRAFT_68872)
SMP: 10807367(SMAC4_00737)
PAN: PODANSg2772
PBEL: QC761_404040(LYS21)
PPSD: QC762_404040(LYS21)
PPSP: QC763_404040(LYS21)
PPSA: QC764_404040(LYS21)
TTT: THITE_2110530
MTM: MYCTH_2307131
CTHR: CTHT_0044760
MGR: MGG_01092
PPEI: PpBr36_08045
PGRI: PgNI_08149
TMN: UCRPA7_2646
SSCK: SPSK_02501
FGR: FGSG_03993 FGSG_11054
FPU: FPSE_02427 FPSE_05284
FPOA: FPOAC1_006422(LYS1_1) FPOAC1_009794(LYS1_2)
FVN: FVRRES_07028 FVRRES_10448
FVR: FVEG_00366 FVEG_08487 FVEG_11679
FOX: FOXG_01149 FOXG_01159
NHE: NECHADRAFT_104905 NECHADRAFT_90471
FFC: NCS54_00169600 NCS54_00936300
FKR: NCS57_00167300 NCS57_00956000
FMU: J7337_001595(LYS1_1) J7337_010079
TRE: TRIREDRAFT_123471
TRR: M419DRAFT_111054
TATV: 25783463(TrAtP1_002614)
TASP: 36614917(LYS21)
MAW: 19248474(LYS21_2) 19249066(LYS21_1)
MAJ: MAA_04642 MAA_08803
MBRN: 26240320(lys1_2) 26243663(lys1_3)
PCHM: VFPPC_01004 VFPPC_01351
CMT: CCM_06007
AMUS: LMH87_005390
PLJ: 28886033(PLICBS_007544) 28888981(PLICBS_008533)
PTKZ: JDV02_002478(LYS21)
VAL: VDBG_04044 VDBG_07402
VDA: VDAG_01275 VDAG_06110
CFJ: CFIO01_11607
CLUP: CLUP02_13734
CHIG: CH63R_05833
CDET: 87948817(CDEST_12317)
SAPO: SAPIO_CDS8181
ELA: UCREL1_11150
PFY: PFICI_06350 PFICI_09647
SSL: SS1G_14306
BFU: BCIN_14g05400
MBE: MBM_09052
PSCO: LY89DRAFT_684190
GLZ: GLAREA_07760
ANI: ANIA_01990
AFM: AFUA_4G10460
ACT: ACLA_049660
NFI: NFIA_105610
AOR: AO090003001165 AO090124000027
ANG: An04g06210
AFV: AFLA_000502 AFLA_009184
ALUC: AKAW2_51586A(LYS1_2)
ACHE: ACHE_10778S(LYS1_1)
APUU: APUU_21064S(LYS1_1)
PCS: N7525_005048
PDP: PDIP_24800
POU: POX_f08046
TMF: EYB26_005247
TRG: TRUGW13939_02747
CIM: CIMG_09081
CPW: CPC735_015150
URE: UREG_05150
ABE: ARB_01923
TVE: TRV_02108
PBL: PAAG_07089
PBN: PADG_01615
AJE: HCAG_06098
BGH: BDBG_02311
PNO: SNOG_08956
PTE: PTT_15621
PTRR: 6347463(PtrM4_036810)
BZE: COCCADRAFT_101614
BSC: COCSADRAFT_32571
BOR: COCMIDRAFT_95545
AALT: CC77DRAFT_1052185
ARAB: EKO05_0009236
ZTR: MYCGRDRAFT_110230
PFJ: MYCFIDRAFT_86887
FFU: CLAFUR5_12241
CBET: CB0940_11003
BCOM: BAUCODRAFT_39689
NPA: UCRNP2_8181
TML: GSTUM_00009173001
SPO: 2539815(lys4)
SOM: SOMG_00682(lys4)
CNE: CND01200
CNB: CNBD5100
CNG: CNAG_00992
CGI: CGB_D3430W
CDEU: CNBG_0572
CDEP: 91088103(L203_103893)
KMG: 30162028(I203_107462)
KNE: 92183145(IAR55_005887)
TMS: TREMEDRAFT_44559
TASA: A1Q1_00939
CCAC: CcaHIS019_0703000(LYS21)
PPL: POSPLDRAFT_89192
TVS: TRAVEDRAFT_110523
DSQ: DICSQDRAFT_45747
PCO: PHACADRAFT_159123
SHS: STEHIDRAFT_90937
HIR: HETIRDRAFT_316739
ADL: AURDEDRAFT_112769
FME: FOMMEDRAFT_76994
GTR: GLOTRDRAFT_112070
RSX: RhiXN_02664
LBC: LACBIDRAFT_291144
CCI: CC1G_06438
ABP: AGABI1DRAFT114278(AGABI1DRAFT_114278)
ABV: AGABI2DRAFT191298(AGABI2DRAFT_191298)
PCUB: JR316_0006175
MRR: Moror_4622
MORE: E1B28_011484(LYS4_1)
SCM: SCHCO_02503178(SCHCODRAFT_02503178)
CPUT: CONPUDRAFT_80635
SLA: SERLADRAFT_468311
WSE: WALSEDRAFT_42693
WIC: J056_002016
UMA: UMAG_04115
PFP: PFL1_06052
SGRA: EX895_001568
MGL: MGL_3987
MRT: MRET_4216
MSYM: MSY001_2206
PGR: PGTG_01903
PTRC: PtA15_10A706
PSTR: Pst134EA_019740
MLR: MELLADRAFT_50387
RIE: OCT59_004379
MBR: MONBRDRAFT_34312
SRE: PTSG_03420
NGR: NAEGRDRAFT_34642
THAR: T8K17_00425
ADE: Adeh_1436
ACP: A2cp1_2511
AFW: Anae109_2393
ANK: AnaeK_2424
AORY: AMOR_52870
APAU: AMPC_18610
PSEU: Pse7367_2223
CYC: PCC7424_0947
CYJ: Cyan7822_1791
NFL: COO91_05563
NED: HUN01_23180(lysS)
NCF: ANSO36C_26370
NCN: BZZ01_06000
CAU: Caur_0328
CHL: Chy400_0353
CAG: Cagg_3603
HAU: Haur_3301
CALL: OZ401_003952
LEK: hrd7_27850
CAP: CLDAP_04770
KBS: EPA93_38780
KBB: ccbrp13_35950
THUG: KNN16_06535(lysS)
TTR: Tter_2761
PMET: G4Y79_18420(lysS)
DRA: DR_1238
DGE: Dgeo_1257
DDR: Deide_13980
DMR: Deima_1358
DGO: DGo_CA1416
DPD: Deipe_2766
DSW: QR90_11530
DCH: SY84_02355
DAB: AUC44_09460
DPU: SU48_09295
DEZ: DKM44_08475(lysS)
DWU: DVJ83_05005(lysS)
DFC: DFI_09345
DEIN: DAAJ005_07905(lysS)
DGA: DEGR_18060
DPH: EHF33_05040(lysS)
DRB: N0D28_09395(lysS)
DAH: DAETH_17180
DAQU: M8445_11600(lysS)
DTAE: LAJ19_07725(lysS)
DMB: E5F05_12480(lysS)
TRA: Trad_1388
TTH: TT_C1550
TTJ: TTHA1914(TTHA1914)
TTS: Ththe16_1914
TTL: TtJL18_1996
TSC: TSC_c01850(lysS1)
THC: TCCBUS3UF1_21080
TOS: Theos_1940
TAQ: TO73_0091
TBC: A0O31_00877
TANT: KNN15_05095(lysS)
MRB: Mrub_2729
MRE: K649_08890
MTAI: Mtai_v1c23280
MSV: Mesil_0445
OPR: Ocepr_1779
MHD: Marky_0673
SCOR: J3U87_19125(lysS)
 » show all
Reference
PMID:21895798
  Authors
Quezada H, Marin-Hernandez A, Aguilar D, Lopez G, Gallardo-Perez JC, Jasso-Chavez R, Gonzalez A, Saavedra E, Moreno-Sanchez R
  Title
The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 82:578-90 (2011)
DOI:10.1111/j.1365-2958.2011.07832.x
Reference
PMID:18524920
  Authors
Quezada H, Aranda C, DeLuna A, Hernandez H, Calcagno ML, Marin-Hernandez A, Gonzalez A
  Title
Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae.
  Journal
Microbiology 154:1656-67 (2008)
DOI:10.1099/mic.0.2008/017103-0
LinkDB

KEGG   ORTHOLOGY: K10977
Entry
K10977                      KO                                     
Symbol
aksA
Name
methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Pathway
map00300  Lysine biosynthesis
map00620  Pyruvate metabolism
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Reaction
R00271  acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
R08213  
R08331  acetyl-CoA:2-oxoadipate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
R08332  acetyl-CoA:2-oxopimelate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K10977  aksA; methanogen homocitrate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K10977  aksA; methanogen homocitrate synthase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K10977  aksA; methanogen homocitrate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14  homocitrate synthase
     K10977  aksA; methanogen homocitrate synthase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K10977
Other DBs
COG: COG0119
GO: 0004410
Genes
CCE: Ccel_1624
SEDM: RBQ61_02100
MJA: MJ_0503
MFE: Mefer_0710
MVU: Metvu_1576
MFS: MFS40622_1791
MIF: Metin_1354
MJH: JH146_1425
MESG: MLAUSG7_0108(aksA)
MESA: MLASG1_1291(aksA)
MIG: Metig_0696
MMP: MMP0153(aksA)
MMQ: MmarC5_1522
MMX: MmarC6_0797
MMZ: MmarC7_1153
MMD: GYY_00785(aksA)
MMAK: MMKA1_01580(cimA)
MMAO: MMOS7_01840(cimA)
MMAD: MMJJ_09310(leuA_1)
MAE: Maeo_0994
MVN: Mevan_1158
MVO: Mvol_1568
MOK: Metok_0640
METF: CFE53_04770(aksA)
MTH: MTH_1630
MMG: MTBMA_c02150(leuA2)
MWO: MWSIV6_0176(aksA)
MTEE: MTTB_13800(aksA)
METC: MTCT_1489
METE: tca_01580(leuA_3)
METZ: METMT2_1469
METK: FVF72_03475
MTHM: FZP57_00770
METJ: FZP68_05780
MST: Msp_1099(leuA2)
METB: AW729_10320(aksA)
MEIS: PXD04_02110
MRU: mru_0385(aksA)
MSI: Msm_0722
MEB: Abm4_0181(aksA)
MMIL: sm9_2160(aksA)
MEYE: TL18_01070(aksA)
MOL: YLM1_0056
MARO: MarbSA_09070(aksA_1) MarbSA_13810(aksA_2)
METV: K4897_04155
MEL: Metbo_2071
MEW: MSWAN_0569
METH: MBMB1_0290(aksA)
MFC: BRM9_1985(aksA)
MFI: DSM1535_0177(aksA)
MCUB: MCBB_0566(aksA)
MSUB: BK009_11615(aksA)
METN: BK008_07190(aksA)
METT: CIT01_06835(aksA)
METO: CIT02_05435(aksA)
MEME: HYG87_07555
MFEG: GCM10025860_11500(aksA)
MEER: NKF70_09710
MFV: Mfer_0964
MKA: MK1209(leuA)
MBA: Mbar_A2192
MBY: MSBRM_2239
MBW: MSBRW_2549
MBAR: MSBR2_0170
MBAK: MSBR3_1047
MAC: MA_3342(leuA)
MMA: MM_2785
MMAZ: MmTuc01_2834
MMJ: MSMAS_1942
MMAC: MSMAC_1183
MVC: MSVAZ_2030
MEK: MSKOL_2008
MLS: MSLAZ_1553
METM: MSMTP_1363
MEF: MSWH1_1527
MEQ: MSWHS_1780
MSJ: MSSAC_2553
MSZ: MSSIH_2157
MSW: MSSIT_2270
MTHR: MSTHT_0432
MTHE: MSTHC_0289
MHOR: MSHOH_1618
MFZ: AOB57_000055(aksA)
MBU: Mbur_0854(cimA)
MMET: MCMEM_0986
MELO: J7W08_02750(aksA)
MMH: Mmah_1162
MHAZ: BHR79_07725(aksA)
MPOT: BKM01_03970(aksA)
MEV: Metev_0432
MZH: Mzhil_1141
MPY: Mpsy_2899
MZI: HWN40_08205(aksA)
MMAV: RE476_02105
MSEB: RE474_12000
MHZ: Metho_0886
MEHF: MmiHf6_03460(leuA_1)
MEES: MmiEs2_06200(leuA_1)
MTP: Mthe_1533
MCJ: MCON_2596(leuA)
MHI: Mhar_1932
MHU: Mhun_1801
MRTJ: KHC33_05405
MLA: Mlab_0232
MEM: Memar_0633
MBG: BN140_1718(aksA)
MEMA: MMAB1_2210(aksA)
MCHK: MchiMG62_07630(aksA)
MSUM: OH143_09885
MRC: R6Y96_02550
MPI: Mpet_2488
MEND: L6E24_09230
MEFW: F1737_00615(aksA)
MAQE: RJ40_05985(aksA)
MFK: E2N92_06115(aksA)
MOU: OU421_03650
MESB: L1S32_07250
MANQ: L1994_01090
MBN: Mboo_0598
MFO: Metfor_2593
MESK: METHP_00368
MPL: Mpal_2142
MPD: MCP_1960(aksA)
MEZ: Mtc_1560(aksA)
RCI: RCIX2647(leuA-4)
HASV: SVXHr_0597(leuA)
HABN: HBNXHr_0575(leuA)
MEUZ: KRP56_01640
 » show all
Reference
PMID:9665716
  Authors
Howell DM, Harich K, Xu H, White RH
  Title
Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.
  Journal
Biochemistry 37:10108-17 (1998)
DOI:10.1021/bi980662p
  Sequence
[mja:MJ_0503]
LinkDB

KEGG   REACTION: R00271
Entry
R00271                      Reaction                               
Name
acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Definition
Acetyl-CoA + H2O + 2-Oxoglutarate <=> (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA
Equation
C00024 + C00001 + C00026 <=> C01251 + C00010
Reaction class
RC00004  C00010_C00024
RC00067  C00026_C01251
RC02754  C00024_C01251
Enzyme
2.3.3.14
Pathway
rn00300  Lysine biosynthesis
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14
     R00271  Acetyl-CoA + H2O + 2-Oxoglutarate <=> (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA
Orthology
K01655  homocitrate synthase [EC:2.3.3.14]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Other DBs
RHEA: 12932
LinkDB

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