KEGG   ORTHOLOGY: K01666
Entry
K01666                      KO                                     
Symbol
mhpE
Name
4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
Pathway
map00360  Phenylalanine metabolism
map00362  Benzoate degradation
map00621  Dioxin degradation
map00622  Xylene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
   00622 Xylene degradation
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
   00621 Dioxin degradation
    K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.39  4-hydroxy-2-oxovalerate aldolase
     K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K01666
Other DBs
RN: R00750
COG: COG0119
GO: 0008701
Genes
ECO: b0352(mhpE)
ECJ: JW0343(mhpE)
EBW: BWG_0241(mhpE)
ECOK: ECMDS42_0274(mhpE)
ECE: Z0452(mhpE)
ECS: ECs_0407(mhpE)
ECF: ECH74115_0427(mhpE)
ETW: ECSP_0416(mhpE)
ELX: CDCO157_0395
EOI: ECO111_0388(mhpE)
EOJ: ECO26_0388(mhpE)
EOH: ECO103_0334(mhpE)
ECOO: ECRM13514_0494(mhpE)
ECOH: ECRM13516_0332(mhpE)
ESL: O3K_19715
ESO: O3O_05580
ESM: O3M_19700
ECK: EC55989_0359(mhpE)
EOK: G2583_0465(mhpE)
ELH: ETEC_0408
ECW: EcE24377A_0376(mhpE)
EUN: UMNK88_402(mhpE)
ENA: ECNA114_0335(mhpE)
ECOS: EC958_0496
ECX: EcHS_A0416(mhpE)
ECM: EcSMS35_0383(mhpE)
ECY: ECSE_0377
ECR: ECIAI1_0353(mhpE)
ECQ: ECED1_0380(mhpE)
EUM: ECUMN_0395(mhpE)
ECT: ECIAI39_0326(mhpE)
EOC: CE10_0320(mhpE)
EBR: ECB_00306(mhpE)
EBL: ECD_00306(mhpE)
EBE: B21_00310(mhpE)
EBD: ECBD_3305
ELO: EC042_0389(mhpE)
ESE: ECSF_0323
EKF: KO11_21820(mhpE)
EDJ: ECDH1ME8569_0339(mhpE)
ELW: ECW_m0430(mhpE)
ELL: WFL_02115(mhpE)
ELP: P12B_c0312(mhpE) P12B_c0370(mhpE)
ECOJ: P423_01850
EMA: C1192_10895(dmpG)
ESZ: FEM44_16335(dmpG)
SSN: SSON_0331(mhpE)
KPN: KPN_02117(mhpE)
KPU: KP1_3212(mhpE)
KPP: A79E_2127
KPT: VK055_0344(dmpG)
KPR: KPR_2662(mhpE)
KPJ: N559_2173
KPX: PMK1_04481(mhpE)
KPNU: LI86_10795
KPNK: BN49_3222(mhpE)
KVA: Kvar_2158
KPE: KPK_2206(mhpE)
KOX: KOX_22670
KOE: A225_3411
KQV: B8P98_11815(dmpG)
KLW: DA718_12110(dmpG)
RAO: DSD31_10730(dmpG)
REE: electrica_02140(mhpE)
CWE: CO701_16970(dmpG)
CYO: CD187_18570(dmpG)
CPOT: FOB25_06035(dmpG)
CFQ: C2U38_05270(dmpG)
CSED: JY391_16890(dmpG)
CIF: AL515_06460(dmpG)
CIE: AN232_24605(dmpG)
CPAR: CUC49_01495(dmpG)
CITZ: E4Z61_11830(dmpG)
CARS: E1B03_06465(dmpG)
EBT: EBL_c19990(mhpE)
KAS: KATP_20220(mhpE)
SYM: K6K13_20590(dmpG)
PSGC: G163CM_06430(mhpE_1) G163CM_10090(mhpE_2)
EBF: D782_1987
EBU: CUC76_00405(dmpG)
SPE: Spro_3025
SERA: Ser39006_017380(dmpG)
SERQ: CWC46_17380(dmpG)
SQU: E4343_00890(dmpG)
ECA: ECA1429(nahM)
PATR: EV46_07235
PATO: GZ59_14680(nahM)
PVZ: OA04_15080(nifV)
EPY: EpC_04020
PLU: plu4081
XNE: XNC1_0240
XNM: XNC2_0241
LRI: NCTC12151_03194(mhpE)
VAG: N646_2394
PAEP: PA1S_20450
PAEG: AI22_13500
PFUW: KF707C_15580(bzaH)
PCQ: PcP3B5_23500(mhpE) PcP3B5_25720(dmpG)
PPU: PP_1791
PPT: PPS_1433
PPX: T1E_4258(cmtG) T1E_4274(tobH)
PPUH: B479_25865
PPUT: L483_06510
PSB: Psyr_3072
PEN: PSEEN0975
PSTT: CH92_19040
PKC: PKB_1193 PKB_3256(amng1) PKB_3604(amng3)
PSES: PSCI_2058(xylK)
PSOS: POS17_2261
PSET: THL1_490
PSIL: PMA3_18060
PKE: DLD99_14425(dmpG) DLD99_14495(dmpG)
PPSH: G5J76_17860(dmpG)
PTRT: HU722_0015010(dmpG)
PQI: KH389_15725(dmpG)
PMUY: KSS95_17240(dmpG)
PMAM: KSS90_10065(dmpG)
PTAE: NCTC10697_02309(dmpG)
AVN: Avin_08740(xylK) Avin_15130(mphE) Avin_42120
AVL: AvCA_08740(xylK) AvCA_15130(mphE) AvCA_42120
ACX: Achr_27750(mphE) Achr_32700(xylK)
HPEG: EAO82_00545(dmpG) EAO82_09435(dmpG)
HAES: LO767_17680(dmpG)
MHC: MARHY0649
ASEI: I8T81_09230(dmpG)
ADV: DJ533_01780(dmpG)
ADS: FPL17_05445(dmpG)
ATN: FM020_06350(dmpG)
ABOU: ACBO_15590(mhpE_1)
SDN: Sden_2668
SEUR: FM038_016470(dmpG)
PTN: PTRA_a0482(mhpE)
KIM: G3T16_05375(dmpG)
LPN: lpg2681
LPH: LPV_3027
LPO: LPO_2962
LPM: LP6_2713
LPF: lpl2608
LPP: lpp2735
LPC: LPC_0455
LPA: lpa_03915
LPE: lp12_2674
LLO: LLO_0366
LFA: LFA_0384
LHA: LHA_2302
LLG: 44548918_00735(bphI)
LJR: NCTC11533_00845(mhpE)
LCJ: NCTC11976_00245(mhpE)
LWA: SAMEA4504053_3185(bphI)
LSS: NCTC12082_02515(bphI)
LADL: NCTC12735_01502(dmpG)
TMC: LMI_2790
HMAR: HVMH_0576
MEJ: Q7A_1101
ATEP: Atep_09840
HALK: CUU95_03820(dmpG)
HVN: EI420_02110(dmpG)
HTX: EKK97_09990(dmpG)
MGEO: CFI10_04585(dmpG)
MSEC: LN244_12105(dmpG)
SOK: D0B54_04235(dmpG)
SINI: GT972_13755(dmpG)
CHRO: CXB49_03860(dmpG)
CRZ: D1345_11515(dmpG)
CHAE: CH06BL_23600(mhpE)
AQS: DKK66_07210(dmpG)
RSO: RSp0895(dmpG)
RSM: CMR15_mp10879(mhpE)
RSE: F504_4322
RPU: CDC45_22090(dmpG)
REH: H16_A1807(mhpE2) H16_B0552(mhpE1)
RME: Rmet_5209(mhpE)
COX: E0W60_03755(dmpG) E0W60_07650(dmpG) E0W60_07795(dmpG)
BPS: BPSS1807(mhpE)
BPM: BURPS1710b_A0890(mhpE)
BPD: BURPS668_A2590(mhpE)
BPSE: BDL_5207(dmpG)
BPSM: BBQ_4325(dmpG)
BPSU: BBN_5270(dmpG)
BPSD: BBX_4373(dmpG)
BPZ: BP1026B_II1937(mhpE)
BPK: BBK_4537(dmpG)
BPSH: DR55_5932(dmpG)
BPSA: BBU_4207(dmpG)
BPSO: X996_5729(dmpG)
BUT: X994_5292(dmpG)
BTE: BTH_II0570(mhpE)
BTQ: BTQ_3864(dmpG)
BTJ: BTJ_4896(dmpG)
BTZ: BTL_5690(dmpG)
BTD: BTI_5186(dmpG)
BTV: BTHA_4520(dmpG)
BTHE: BTN_5352(dmpG)
BTHM: BTRA_5626(dmpG)
BTHA: DR62_5490
BTHL: BG87_5697(dmpG)
BOK: DM82_6079(dmpG)
BOC: BG90_4586(dmpG)
BSAV: WS86_28135
BVE: AK36_3502(dmpG)
BCJ: BCAM2121
BCEN: DM39_1991(dmpG) DM39_4966(dmpG)
BCEW: DM40_5000(dmpG)
BCEO: I35_6003
BMUL: NP80_3434(dmpG) NP80_3873(dmpG)
BCON: NL30_34160
BLAT: WK25_27480
BSEM: WJ12_26060
BMEC: WJ16_20010
BANN: JFN94_18715(dmpG) JFN94_26780(dmpG)
BGU: KS03_3374(dmpG) KS03_5342
BGO: BM43_7072(dmpG)
BUK: MYA_5002
BUL: BW21_2671(dmpG) BW21_4722(dmpG)
BXB: DR64_1245(dmpG) DR64_3311(dmpG) DR64_4657(dmpG)
BFN: OI25_255(dmpG)
PARB: CJU94_31730(dmpG)
PHS: C2L64_35640(dmpG)
PTER: C2L65_38855(dmpG)
PGP: CUJ91_31740(dmpG)
PTRO: G5S35_21490(dmpG)
PGIS: I6I06_26785(dmpG)
PACP: FAZ97_22980(dmpG)
PEW: KZJ38_28105(dmpG)
PPNM: LV28_21850
PPUL: RO07_16240
PSPU: NA29_20920
PAPI: SG18_00060
PAND: DRB87_06760(dmpG)
PFIB: PI93_020350(dmpG)
BAV: BAV0600(bphF)
BHZ: ACR54_00829(mhpE)
ACHR: C2U31_03430(dmpG)
PUT: PT7_2460
PUD: G9Q38_01255(dmpG) G9Q38_15010(dmpG)
AFQ: AFA_13960(dmpG)
AAQU: D3M96_14820(dmpG)
AAMM: FE795_12915(dmpG)
PIG: EGT29_26650(dmpG)
KGY: EHF36_03355(dmpG)
POL: Bpro_5136
ACK: C380_15915(bphF)
VBO: CKY39_22055(dmpG)
CTES: O987_08265
HPSE: HPF_15300(mhpE)
DIH: G7047_22420(dmpG)
DRG: H9K76_21090(dmpG)
SIMP: C6571_19090(dmpG)
STHM: IS481_17700(dmpG)
JAG: GJA_232(dmpG)
HEE: hmeg3_19565(dmpG)
DAR: Daro_3238
CCF: YSQ_01790
SHAL: SHALO_2223
ABU: Abu_1489
ABT: ABED_1386
ATP: ATR_1318
ACIB: ACBT_1008
ACRE: ACRYA_0716
ATHR: ATH_0790
AELL: AELL_1860
AAQI: AAQM_1697
ASUI: ASUIS_0994
ACLO: ACLO_1683
ALK: ALEK_1376
AMAR: AMRN_1917
APAI: APAC_0989
HBV: ABIV_1064
HEBR: AEBR_1328
PACO: AACT_1972
ARC: ABLL_1976
SUN: SUN_2142
GLO: Glov_0787
DMA: DMR_24610(nahM)
DPI: BN4_11362(nahM)
HOH: Hoch_1083
PCAY: FRD00_17515(dmpG)
RBT: NOVO_02090(leuA)
ARA: Arad_7255
RLS: HB780_13245(dmpG)
ABAW: D5400_20370(dmpG)
BTR: BT_2080
XAU: Xaut_0938
XDI: EZH22_00035(dmpG)
MSL: Msil_1479
MTUN: MTUNDRAET4_3892(mhpE)
NTD: EGO55_02910(dmpG) EGO55_13670(dmpG)
MMED: Mame_00137(mhpE)
MLUT: JET14_11065(dmpG)
CAUL: KCG34_11030(dmpG)
PHP: PhaeoP97_04061(leuA_2)
PPIC: PhaeoP14_03833(leuA_2)
OCT: FTO60_10560(dmpG)
CEH: CEW89_11445(dmpG)
THAA: CFI11_19395(dmpG)
MON: G8E03_15165(dmpG)
NOV: TQ38_027305(dmpG)
NOT: C7W88_20915(dmpG)
NOG: GKE62_05085(dmpG)
SGI: SGRAN_1422(mhpE2)
SPHO: C3E99_03975(dmpG)
SPHU: SPPYR_1439(mhpE)
RDI: CMV14_04950(dmpG)
SPHM: G432_01975
SPHF: DM480_04890(dmpG)
SPHA: D3Y57_15225(dmpG)
SLAN: GV829_01845(dmpG)
SPHB: EP837_03396(mhpE)
SUFL: FIL70_18670(dmpG)
SBAR: H5V43_20330(dmpG) H5V43_22340(dmpG)
SPPH: KFK14_16520(dmpG)
SPHY: CHN51_06975(dmpG) CHN51_18315(dmpG)
PALG: HFP57_16675(dmpG)
PHAO: HF685_05510(dmpG)
ERK: CD351_08255(dmpG)
PHZ: CHX26_05330(dmpG)
TMO: TMO_3169(mhpE) TMO_b0123
MAGQ: MGMAQ_0651
BSS: BSUW23_00995(rhiG)
BCA: BCE_2157
BCX: BCA_2155(dmpG)
BCF: bcf_10215
BCER: BCK_24220
BTL: BALH_1844
BMYC: DJ92_4638(dmpG)
BTRO: FJR70_09220(dmpG)
BNT: GSN03_10150(dmpG)
BACO: OXB_2503
BFD: NCTC4823_00793(dmpG)
BMQ: BMQ_1728 BMQ_3587(dmpG)
BMD: BMD_1715 BMD_3572(dmpG)
BMEG: BG04_4046 BG04_461(dmpG)
BEO: BEH_08655
BKO: CKF48_08550(dmpG)
GTN: GTNG_3151(nbaI)
GZA: IC807_03365(dmpG)
ASED: IRT44_17620(dmpG)
LYB: C3943_22675(dmpG)
LYZ: DCE79_01755(dmpG)
LYG: C1N55_08075(dmpG)
LPAK: GDS87_20230(dmpG)
PRD: F7984_08685(dmpG) F7984_12025(dmpG)
RUE: DT065_12685(dmpG) DT065_13790(dmpG) DT065_15115(dmpG) DT065_15205(dmpG)
SALE: EPH95_15040(dmpG)
NTM: BTDUT50_14550(dmpG)
BOU: I5818_04800(dmpG)
HYI: K2M58_04700(dmpG) K2M58_09710(dmpG)
PMW: B2K_02290
PRI: PRIO_1606
PSWU: SY83_12875
PALO: E6C60_3197
ASOC: CB4_02452
AAC: Aaci_1619
AAD: TC41_1515(mhpE)
SIV: SSIL_0066(nbaI) SSIL_3690
SOB: CSE16_14630(dmpG)
KUR: ASO14_173
KZO: NCTC404_01743(mhpE)
SPAE: E2C16_04460(dmpG) E2C16_12280(dmpG)
ESR: ES1_22750
ESU: EUS_17010
COO: CCU_13650
CSO: CLS_02690
DSY: DSY3306
PTH: PTH_0483(LeuA)
TFR: BR63_18625(dmpG)
AACX: DEACI_1575
TMR: Tmar_1781
SAY: TPY_0642(mhpE)
BPRS: CK3_33700
CHY: CHY_1280(mhpE)
MTA: Moth_1775
MHAP: JFY71_09935(dmpG)
SPOA: EQM13_05625(dmpG)
LPIL: LIP_2173
MTU: Rv3469c(mhpE) Rv3534c(hsaF)
MTC: MT3575(bphI-1) MT3638(bphI-2)
MRA: MRA_3509(mhpE) MRA_3573(bphI)
MTD: UDA_3469c(mhpE) UDA_3534c
MBO: BQ2027_MB3498C(mhpE) BQ2027_MB3564C(hsaf)
MBB: BCG_3534c(mhpE) BCG_3598c
MBT: JTY_3534(mhpE) JTY_3599
MAF: MAF_34840(mhpE) MAF_35460
MPA: MAP_0533
MAO: MAP4_3334
MAVI: RC58_16535
MAVU: RE97_16570
MAV: MAV_0627
MID: MIP_00991
MYO: OEM_05440
MIR: OCQ_05520
MMAL: CKJ54_02610(dmpG)
MLP: MLM_0772
MMAN: MMAN_48330(bphI-2)
MMM: W7S_02630
MSHG: MSG_03538(mhpE) MSG_04519(bphI-2)
MFJ: MFLOJ_23740 MFLOJ_41030(bphI-2)
MSIM: MSIM_29450(bphI-2)
MSAK: MSAS_13470(mhpE) MSAS_28750(bphI-2) MSAS_43780
MKU: I2456_25495(dmpG)
MGRO: FZ046_02630(dmpG) FZ046_24415(dmpG)
MNV: MNVI_12160(bphI-2)
MPAG: C0J29_01125(dmpG) C0J29_27545(dmpG) C0J29_30935(dmpG)
MGOR: H0P51_01125(dmpG) H0P51_02525(dmpG) H0P51_25600(dmpG)
MCOO: MCOO_26850(bphI-2) MCOO_46660(mhpE)
MSEO: MSEO_27460(mhpE) MSEO_34130(bphI-2)
MPSE: MPSD_43480(mhpE) MPSD_52200
MSHO: MSHO_04940 MSHO_21830(mhpE)
MGAU: MGALJ_37980(bphI-2)
MBRD: MBRA_01260(mhpE) MBRA_20390
MSHJ: MSHI_39070
MKR: MKOR_35810(bphI-2) MKOR_36590
MDF: K0O62_25470(dmpG)
MMAM: K3U93_22470(dmpG)
MHOL: K3U96_03315(dmpG)
MHER: K3U94_20775(dmpG)
MSEN: K3U95_25160(dmpG)
MPAE: K0O64_09025(dmpG) K0O64_25850(dmpG)
MSPG: F6B93_20285(dmpG)
MSG: MSMEI_4052 MSMEI_5778(bphI-2)
MGI: Mflv_1522
MVQ: MYVA_5129
MTHN: 4412656_04050(bphI)
MHAS: MHAS_03727 MHAS_04021(mhpE)
MDU: MDUV_49660(bphI-2)
MCHT: MCHIJ_19800(bphI-2)
MAUU: NCTC10437_01140(mhpE) NCTC10437_02746(bphI_1) NCTC10437_04999(bphI_2)
MMAG: MMAD_42140 MMAD_47980(bphI-2)
MMOR: MMOR_12270(bphI-2)
MFX: MFAL_33600(bphI-2)
MAIC: MAIC_05760(bphI-2) MAIC_22100
MIJ: MINS_00180(bphI-2_1) MINS_43250(bphI-2_2)
MALV: MALV_42720(bphI-2)
MTY: MTOK_07660 MTOK_22760(bphI-2)
MPSC: MPSYJ_16300(bphI-2)
MARZ: MARA_21770 MARA_48410(bphI-2)
MGAD: MGAD_37060(bphI-2)
MHEV: MHEL_01570 MHEL_28230(bphI-2) MHEL_40950(mhpE)
MSAR: MSAR_10540(bphI-2)
MANY: MANY_02560(mhpE) MANY_32600(bphI-2)
MAUB: MAUB_26340 MAUB_47410(mhpE)
MPOF: MPOR_20400 MPOR_53420(bphI-2)
MPHU: MPHO_21660(mhpE) MPHO_44020(bphI-2)
MMUC: C1S78_007395(dmpG) C1S78_025280(dmpG)
MMAT: MMAGJ_34850(bphI-2) MMAGJ_45410(mhpE)
MBOK: MBOE_04190(bphI-2) MBOE_53430(mhpE)
MFG: K6L26_05675(dmpG)
MSEI: MSEDJ_01970(bphI-2)
MFLV: NCTC10271_00510(bphI)
MABB: MASS_0596
MCHE: BB28_03000
MSTE: MSTE_00585
MTER: 4434518_03651(bphI)
MMIN: MMIN_05360(mhpE) MMIN_06630(bphI-2_1) MMIN_12010(bphI-2_2)
MHIB: MHIB_23770(bphI-2_1) MHIB_30690(bphI-2_2)
MPAK: MIU77_02190(dmpG)
CDR: CDHC03_1949(mhpE)
CAMG: CAMM_02595
CLIZ: G7Y31_11640(dmpG)
NFR: ERS450000_00749(dmpG_1) ERS450000_01014(dmpG_2) ERS450000_03770(mhpE)
NCY: NOCYR_0495(mhpE)
NSR: NS506_01252(mhpE)
NOZ: DMB37_23575(dmpG)
NOD: FOH10_28770(dmpG)
NAH: F5544_02620(dmpG)
NAD: NCTC11293_01237(mhpE_1) NCTC11293_04251(mhpE_2) NCTC11293_04415(mhpE_3)
NIE: KV110_03010(dmpG)
NTC: KHQ06_03695(dmpG) KHQ06_23930(dmpG)
NHU: H0264_03805(dmpG)
NYA: LTV02_28940(dmpG)
NGP: LTT66_15385(dmpG) LTT66_28995(dmpG) LTT66_34600(dmpG)
RQI: C1M55_04085(dmpG) C1M55_29425(dmpG)
REQ: REQ_42060
RBY: CEJ39_02110(dmpG) CEJ39_23375(dmpG)
RHS: A3Q41_02907(mhpE)
RRZ: CS378_11835(dmpG) CS378_19560(dmpG) CS378_23185(dmpG) CS378_24200(dmpG)
RRT: 4535765_04741(mhpE)
RCR: NCTC10994_02788(dmpG)
RTM: G4H71_04585(dmpG) G4H71_07415(dmpG)
RKO: JWS14_19325(dmpG) JWS14_24465(dmpG) JWS14_31725(dmpG) JWS14_41340(dmpG) JWS14_47125(dmpG)
RGO: KYT97_14725(dmpG) KYT97_23115(dmpG)
GPO: GPOL_c41170(hsaF)
GOR: KTR9_0812(hsaF)
GOC: CXX93_11335(dmpG)
GIT: C6V83_12290(dmpG)
GAV: C5O27_00905(dmpG) C5O27_10800(dmpG)
GOD: GKZ92_03925(dmpG) GKZ92_16330(dmpG)
GAM: GII34_11005(dmpG) GII34_19575(dmpG)
GPD: GII33_03280(dmpG) GII33_08540(dmpG) GII33_16065(dmpG) GII33_21665(dmpG)
GJI: H1R19_04000(dmpG) H1R19_16275(dmpG)
GOI: LK459_05115(dmpG) LK459_10075(dmpG)
SPIN: KV203_17385(dmpG) KV203_17515(dmpG)
TPR: Tpau_3800
DIT: C3V38_09240(dmpG)
DIZ: CT688_01915(dmpG) CT688_03155(dmpG)
TOY: FO059_00405(dmpG)
SGR: SGR_564
SCB: SCAB_15191 SCAB_2071(mhpE)
SALU: DC74_7440
SALL: SAZ_38405
STRM: M444_14905
SLE: sle_57500(sle_57500)
SKY: D0C37_31235(dmpG)
SCAD: DN051_00520(dmpG) DN051_40290(dmpG)
SGE: DWG14_08257(mhpE)
SDX: C4B68_37440(dmpG)
SCYA: EJ357_31440(dmpG)
SNQ: CP978_25535(dmpG)
STIR: DDW44_01585(dmpG)
SNK: CP967_03290(dmpG) CP967_06135(dmpG)
SSPO: DDQ41_10370(dmpG)
SAQU: EJC51_46940(dmpG)
SSUB: CP968_28040(dmpG)
SPHV: F9278_04310(dmpG)
SCHA: CP983_10660(dmpG)
SGX: H4W23_38500(dmpG)
SPLA: CP981_35165(dmpG)
SVD: CP969_00505(dmpG)
SCAL: I6J39_28915(dmpG)
SPRA: CP972_27630(dmpG)
SXN: IAG42_26620(dmpG)
STRY: EQG64_01405(dmpG)
KSK: KSE_23710
YIA: LO772_34590(dmpG)
MCAW: F6J84_14975(dmpG)
AARC: G127AT_05520(dmpG)
SALC: C2138_13080(dmpG)
SALD: FVA74_01595(dmpG)
LTR: EVS81_03260(dmpG)
HEA: HL652_17945(dmpG)
ARTP: E5206_04525(dmpG) E5206_14565(dmpG)
GPR: JQN66_16635(dmpG)
PAEY: KUF55_17740(dmpG)
JLI: EXU32_15360(dmpG)
JME: EEW87_015415(dmpG)
PEI: H9L10_13715(dmpG)
AUS: IPK37_11685(dmpG)
GYU: FE374_15260(dmpG)
RAIN: Rai3103_00290(dmpG)
PRV: G7070_02140(dmpG)
NDK: I601_0557(mhpE) I601_3471
NBE: Back2_27170(bphI-2)
NANO: G5V58_09745(dmpG)
NARO: CFH99_00775(dmpG) CFH99_13570(dmpG)
NPI: G7071_04105(dmpG) G7071_15955(dmpG)
AEZ: C3E78_16535(dmpG)
AEB: C6I20_03245(dmpG)
NDA: Ndas_2258
ACTW: F7P10_01800(dmpG)
AGRA: AGRA3207_000998(dmpG)
SRO: Sros_9113
NGN: LCN96_51365(dmpG)
FAL: FRAAL4663
NML: Namu_4081
AMD: AMED_4220(mhpE)
AMN: RAM_21495
AMM: AMES_4170(mhpE)
AMZ: B737_4170(mhpE)
AOI: AORI_3691(mhpE)
AMQ: AMETH_2976(mhpE)
AMYC: CU254_20390(dmpG)
AMYY: YIM_27900
PDX: Psed_4179
PAUT: Pdca_38540(mhpE)
PBRO: HOP40_31855(dmpG)
SACE: GIY23_13345(dmpG)
MIL: ML5_3357
MTUA: CSH63_33400(dmpG)
MTEM: GCE86_19385(dmpG)
MCAB: HXZ27_12170(dmpG)
MCRA: ID554_06975(dmpG) ID554_07045(dmpG) ID554_30895(dmpG)
AFS: AFR_23745
PLK: CIK06_08080(dmpG) CIK06_17415(dmpG)
VER: HUT12_12160(dmpG) HUT12_13560(dmpG) HUT12_26055(dmpG)
NHY: JQS43_06615(dmpG)
RMAR: GBA65_17345(dmpG)
ERZ: ER308_02425(dmpG)
SYW: SYNW0424
RCA: Rcas_2410
CAU: Caur_1351
CAG: Cagg_2034
TRO: trd_1392
KBS: EPA93_11945(dmpG)
TTJ: TTHB246(TTHB246)
TSC: TSC_c11570(dmpG)
TANT: KNN15_10815(dmpG)
TTF: THTE_4184
TPI: TREPR_1324(dmpG)
BRM: Bmur_0128
BIP: Bint_1446
FSC: FSU_2557
GFL: GRFL_0092
MARM: YQ22_08335
NDO: DDD_3546
CTS: Ctha_2137
MLA: Mlab_0987
HNO: LT974_08825(dmpG)
HLM: DV707_09475(dmpG)
MARC: AR505_0545
NMR: Nmar_0140
AG: CAA43227(dmpG)
 » show all
Reference
  Authors
Lee SJ, Ko JH, Kang HY, Lee Y
  Title
Coupled expression of MhpE aldolase and MhpF dehydrogenase in Escherichia coli.
  Journal
Biochem Biophys Res Commun 346:1009-15 (2006)
DOI:10.1016/j.bbrc.2006.06.009
  Sequence
[eco:b0352]
Reference
PMID:22316175 (EC:4.1.3.39 4.1.3.43)
  Authors
Baker P, Hillis C, Carere J, Seah SY
  Title
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
  Journal
Biochemistry 51:1942-52 (2012)
DOI:10.1021/bi201832a
  Sequence
[ttj:TTHB246]
LinkDB

KEGG   ORTHOLOGY: K18365
Entry
K18365                      KO                                     
Symbol
bphI, xylK, nahM, tesG
Name
4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]
Pathway
map00362  Benzoate degradation
map00621  Dioxin degradation
map00622  Xylene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00622 Xylene degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00621 Dioxin degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.39  4-hydroxy-2-oxovalerate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
    4.1.3.43  4-hydroxy-2-oxohexanoate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K18365
Other DBs
RN: R00750 R05298
COG: COG0119
GO: 0008701
Genes
PSD: DSC_09375
RGL: CS053_01770(dmpG)
RTH: LRK53_10290(dmpG)
RBD: ALSL_0877 ALSL_1082
VAF: D1115_22440(dmpG)
PRE: PCA10_13840
PFUW: KF707C_12190 KF707C_16050(salH) KF707C_16230(bphX3)
PPI: ND084(nahM)
PPUT: L483_14055
PPUN: PP4_27280(mhpE)
PPUU: PputUW4_01662(mhpE)
PKC: PKB_4237(nahM)
PSET: THL1_1435
PSIL: PMA3_11725
PKE: DLD99_14740(dmpG)
PUM: HGP31_20770(dmpG)
PPSH: G5J76_13480(dmpG)
PLAL: FXN65_06430(dmpG)
PAZE: KSS91_19285(dmpG)
PTAE: NCTC10697_02055(bphI)
AVN: Avin_30570(lapG)
AVL: AvCA_30570(lapG)
AVD: AvCA6_30570(lapG)
MARJ: MARI_05460(bphI)
ASJ: AsACE_CH00352(nahM)
ADV: DJ533_16960(dmpG)
ARJ: DOM24_01575(dmpG)
AWU: BEN71_02690(dmpG)
ACUM: C9E88_006015(dmpG)
ALW: FOB21_11710(dmpG)
ATN: FM020_13980(dmpG)
ACHI: CDG60_02965(dmpG)
ALJ: G8D99_13400(dmpG)
AWG: GFH30_01715(dmpG)
ASHA: G8E00_02255(dmpG)
ATG: J4G44_04390(dmpG)
AVB: RYU24_27150(mhpE)
ABOU: ACBO_27740(mhpE_2)
SPL: Spea_2116
SHL: Shal_2088
SWD: Swoo_1390
CBER: B5D82_11260(dmpG)
THT: E2K93_11210(dmpG)
PHA: PSHAa2143(mhpE)
PTN: PTRA_a2596(bphI)
PNG: PNIG_a2790(bphI)
SALH: HMF8227_02732(bphI)
TTU: TERTU_1283(dmpG)
SNAN: I6N98_10790(dmpG)
HALC: EY643_13285(dmpG)
AFUS: EYZ66_02685(dmpG) EYZ66_12975(dmpG)
CYQ: Q91_0510 Q91_1491(lapG)
CZA: CYCME_0969(lapG) CYCME_2101(dmpG)
CYY: CPC19_05395(dmpG) CPC19_10505(dmpG)
BLEP: AL038_01290(dmpG)
THIS: HZT40_10615(dmpG)
AEH: Mlg_2462
KAK: Kalk_07865(dmpG)
MPRI: MP3633_3149(mhpE)
MGEO: CFI10_00435(dmpG) CFI10_04970(dmpG) CFI10_06050(dmpG)
MSEC: LN244_04515(dmpG) LN244_04765(dmpG) LN244_11320(dmpG)
NCU: F0U83_03055(dmpG)
NJP: NEJAP_0673(mhpE)
NIK: F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)
ASIM: FE240_03470(dmpG)
SOK: D0B54_06190(dmpG)
SINI: GT972_14660(dmpG)
FCE: JN531_005840(dmpG)
TBN: TBH_C0930
GPB: HDN1F_27070(tesG)
NZO: SAMEA4504057_0444(bphI)
NCI: NCTC10296_00917(bphI)
NWD: H3L96_04775(dmpG)
NDU: LVJ88_00580(dmpG)
PTES: JQU52_04850(dmpG)
USU: LVJ78_03650(dmpG)
RPI: Rpic_4617
REH: H16_B0595(bpHI)
CNC: CNE_2c05400(bpHI)
RME: Rmet_1319(bphI)
CTI: RALTA_B0399(mhpE)
COX: E0W60_08015(dmpG)
BCJ: BCAM1615(bphI)
BCEN: DM39_3381(dmpG) DM39_4832(dmpG)
BCEO: I35_5475(bphI)
BCED: DM42_4991(dmpG) DM42_6343(dmpG)
BMEC: WJ16_26800
BANN: JFN94_19135(dmpG) JFN94_25660(dmpG)
BURK: DM992_32615(dmpG)
BXE: Bxe_C1187(bphI)
BXB: DR64_8618(dmpG)
BFN: OI25_4591(dmpG)
PARB: CJU94_37880(dmpG) CJU94_38125(dmpG)
PMEG: FNZ07_21155(dmpG)
CABA: SBC2_49000(bphI)
LIMN: HKT17_03830(dmpG)
AXY: AXYL_04307(dmpG)
RFR: Rfer_0454
PNA: Pnap_4142
AJS: Ajs_0224
AMON: H9L24_14175(dmpG)
VEI: Veis_2781
VBO: CKY39_28495(dmpG)
CTES: O987_07730
COF: FOZ74_08315(dmpG)
HPSE: HPF_01850(bphI)
HYN: F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)
HTN: KI616_01945(dmpG)
DIH: G7047_09695(dmpG)
SIMP: C6571_13625(dmpG)
MELA: C6568_07850(dmpG)
MJE: LVC68_01015(dmpG)
STHM: IS481_10550(dmpG)
METP: C1M51_06440(dmpG) C1M51_16320(dmpG)
JAJ: EKL02_01800(dmpG) EKL02_13150(dmpG)
LCH: Lcho_3340
SNN: EWH46_19310(dmpG)
IDC: LRM40_19585(dmpG)
ABRE: pbN1_20580(mhpE)
DEY: HYN24_14110(dmpG) HYN24_14200(dmpG)
QAU: KI612_15145(dmpG)
FLE: KI610_08595(dmpG) KI610_13435(dmpG) KI610_15450(dmpG)
AZO: azo1857(lapG) azo1972(mhpE) azo2431(nahM)
ACOM: CEW83_03610(dmpG)
AZD: CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)
AZR: CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)
THK: CCZ27_04605(dmpG) CCZ27_10750(dmpG)
AZQ: G3580_00550(dmpG) G3580_08280(dmpG)
ACIB: ACBT_0259(dmpG)
AFC: AFAEC_1844(dmpG)
AAQI: AAQM_0982(dmpG)
ACLO: ACLO_a0139(dmpG)
ADZ: ADFLV_2551(dmpG)
ALK: ALEK_0383(dmpG)
AANA: AANAER_1260(dmpG)
ARC: ABLL_2442
SHZ: shn_33310
CID: P73_1382
TEC: AKL02_008270(dmpG)
SGI: SGRAN_1579(mhpE)
SJP: SJA_C1-11910(mhpE_xylK)
SINB: SIDU_08310
SHYD: CJD35_06515(dmpG)
SBAR: H5V43_20635(dmpG)
SFLA: SPHFLASMR4Y_02366(bphI)
TFV: IDJ81_04960(dmpG)
TXI: TH3_21418
HTL: HPTL_0047
GGH: GHH_c14840(pheE)
AAD: TC41_0802(mhpE)
BTS: Btus_0969
KYR: CVV65_10345(dmpG) CVV65_11290(dmpG)
DHD: Dhaf_1245
TOC: Toce_0378
 » show all
Reference
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence
LinkDB

KEGG   REACTION: R00750
Entry
R00750                      Reaction                               
Name
4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)
Definition
Acetaldehyde + Pyruvate <=> 4-Hydroxy-2-oxopentanoate
Equation
Reaction class
RC00307  C00022_C03589
RC00371  C00084_C03589
Enzyme
Pathway
rn00360  Phenylalanine metabolism
rn00362  Benzoate degradation
rn00621  Dioxin degradation
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Orthology
K01666  4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
K18365  4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]
Other DBs
RHEA: 22627
LinkDB

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