KEGG   ORTHOLOGY: K01705
Entry
K01705                      KO                                     
Symbol
LYS4
Name
homoaconitate hydratase [EC:4.2.1.36]
Pathway
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Reaction
R04371  homoisocitrate hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K01705  LYS4; homoaconitate hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.36  homoaconitate hydratase
     K01705  LYS4; homoaconitate hydratase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K01705
Other DBs
COG: COG1048
GO: 0004409
Genes
SCE: YDR234W(LYS4)
SEUB: DI49_0416
SPAO: SPAR_D04320
AGO: AGOS_ABL106C
ERC: Ecym_5123
KLA: KLLA0_C15125g
KMX: KLMA_30527(LYS4)
LTH: KLTH0E10582g
VPO: Kpol_1031p57
ZRO: ZYRO0A10076g
CGR: 2890081(GVI51_K10813)
NCS: NCAS_0B02660(NCAS0B02660)
NDI: NDAI_0C05030(NDAI0C05030)
TPF: TPHA_0L01150(TPHA0L01150)
TBL: TBLA_0A01460(TBLA0A01460)
TGB: HG536_0H01840
TDL: TDEL_0B01800(TDEL0B01800)
KAF: KAFR_0E02730(KAFR0E02730)
KNG: KNAG_0A04240(KNAG0A04240)
ZMK: HG535_0F05020
SLUD: SCDLUD_001925
DHA: DEHA2F07238g
PIC: PICST_88705(LYS4)
PGU: PGUG_01420
SPAA: SPAPADRAFT_58782(LYS4)
LEL: PVL30_004416(LYS4)
LBG: 92209228(LODBEIA_P40320)
CAL: CAALFM_C404410CA(LYS4)
CTP: CTRG_03911
COT: CORT_0B00840
CDU: CD36_44080
CTEN: 18246180(LYS4)
CLU: CLUG_00676
CLUS: A9F13_17g00583
CAUR: CJI96_0000218
PPA: PAS_chr4_0795
PKZ: C5L36_0B00600
BNN: FOA43_001879(LYS4)
BBRX: BRETT_004628(LYS4)
OPA: HPODL_02077
YLI: 2912118(YALI2_E01707g)
SLB: AWJ20_348(LYS4)
NCR: NCU08898(lys-6)
NTE: NEUTE1DRAFT58933(NEUTE1DRAFT_58933)
SMP: 10804255(SMAC4_05116)
PAN: PODANSg8469
PBEL: QC761_206510(LYS4)
PPSD: QC762_0038220(LYS4)
PPSP: QC763_206510(LYS4)
PPSA: QC764_206510(LYS4)
TTT: THITE_2124288
MTM: MYCTH_2301648
CTHR: CTHT_0069590
MGR: MGG_04842
PPEI: PpBr36_03207
PGRI: PgNI_01490
TMN: UCRPA7_611
SSCK: SPSK_03952
FGR: FGSG_10949
FPU: FPSE_06063
FPOA: FPOAC1_009694(LYS4) FPOAC1_012803
FVN: FVRRES_10333
FVR: FVEG_11644
FOX: FOXG_12892
NHE: NECHADRAFT_103327 NECHADRAFT_78315 NECHADRAFT_95300
FFC: NCS54_01005400
FKR: NCS57_00218100 NCS57_00999500
FMU: J7337_010041(LYS4)
TRE: TRIREDRAFT_81570
TRR: M419DRAFT_142874
TASP: 36612066(LYS4)
MAW: 19251867(LYS4_3) 19253319(LYS4_1)
MAJ: MAA_04686 MAA_09361
MBRN: 26240367(LYS4_1) 26243995(LYS4_0)
PCHM: VFPPC_00805
CMT: CCM_07793
AMUS: LMH87_002766
PLJ: 28892921(PLICBS_009087)
PTKZ: JDV02_004274(LYS4)
VAL: VDBG_00257
VDA: VDAG_08540
CFJ: CFIO01_08629
CLUP: CLUP02_07655
CHIG: CH63R_04010 CH63R_10446
CDET: 87941043(CDEST_04540) 87943557(CDEST_07054)
SAPO: SAPIO_CDS2378 SAPIO_CDS2954
ELA: UCREL1_5880
PFY: PFICI_04889
SSL: SS1G_01026
BFU: BCIN_14g00430(Bclys4)
MBE: MBM_05638
PSCO: LY89DRAFT_738951
GLZ: GLAREA_01173
ANI: ANIA_06521
AFM: AFUA_5G08890
ACT: ACLA_011660
NFI: NFIA_078420
AOR: AO090701000041
ANG: An15g00350
AFV: AFLA_004530
ALUC: AKAW2_60650A(LYS4)
ACHE: ACHE_50239A(LYS4)
APUU: APUU_10764A(LYS4)
PCS: N7525_011096
PDP: PDIP_05800
POU: POX_c04492
TMF: EYB26_009661
TRG: TRUGW13939_08882
CIM: CIMG_02639
CPW: CPC735_037180
URE: UREG_03117
ABE: ARB_04155
TVE: TRV_03936
PBL: PAAG_03612
PBN: PADG_06215
AJE: HCAG_06854
BGH: BDBG_09384
PNO: SNOG_01131(SNOG_01129 SNOG_01130)
PTE: PTT_19520
PTRR: 6341958(PtrM4_095890)
BZE: COCCADRAFT_82932
BSC: COCSADRAFT_152920
BOR: COCMIDRAFT_86014
AALT: CC77DRAFT_1042638
ARAB: EKO05_0008657
ZTR: MYCGRDRAFT_68535
PFJ: MYCFIDRAFT_202095
FFU: CLAFUR5_03230
CBET: CB0940_03357
BCOM: BAUCODRAFT_34146
NPA: UCRNP2_10443
TML: GSTUM_00011608001
SPO: 2542867(lys2)
SOM: SOMG_02039(lys2)
CNE: CNK00580
CNB: CNBK2910
CNG: CNAG_02565
CGI: CGB_K3700C
CDEU: CNBG_3213
CDEP: 91088695(L203_104485)
KMG: 30164303(I203_106012)
KNE: 92183516(IAR55_006258)
TMS: TREMEDRAFT_44947
TASA: A1Q1_04925
CCAC: CcaHIS019_0702660(LYS4)
TVS: TRAVEDRAFT_150870
DSQ: DICSQDRAFT_155148
PCO: PHACADRAFT_252820
SHS: STEHIDRAFT_72757
HIR: HETIRDRAFT_314980
PSQ: PUNSTDRAFT_66471
ADL: AURDEDRAFT_112541
FME: FOMMEDRAFT_76165
GTR: GLOTRDRAFT_107515
RSX: RhiXN_03086
LBC: LACBIDRAFT_184939
CCI: CC1G_14391
ABP: AGABI1DRAFT59676(AGABI1DRAFT_59676)
ABV: AGABI2DRAFT184036(AGABI2DRAFT_184036)
PCUB: JR316_0006214
MRR: Moror_4605
MORE: E1B28_011496(LYS4_2)
SCM: SCHCO_02541718(SCHCODRAFT_02541718)
CPUT: CONPUDRAFT_119840
SLA: SERLADRAFT_468242
WSE: WALSEDRAFT_59020
WIC: J056_004489
UMA: UMAG_10689
PFP: PFL1_04410
SGRA: EX895_000383
MGL: MGL_3298
MRT: MRET_2395
MSYM: MSY001_3108
PGR: PGTG_09399
PTRC: PtA15_8A618
PSTR: Pst134EA_025611
MLR: MELLADRAFT_105205
RIE: OCT59_029567
MBR: MONBRDRAFT_32374
SRE: PTSG_09627
ACAN: ACA1_061650
PIF: PITG_12462
PSOJ: PHYSODRAFT_562967
SPAR: SPRG_03993
NGR: NAEGRDRAFT_80875
CALL: OZ401_000503(lysF)
UAM: UABAM_01973
ABA: Acid345_2965
IAL: IALB_1150
MRO: MROS_2220
CABY: Cabys_582
 » show all
Reference
PMID:23106124
  Authors
Fazius F, Shelest E, Gebhardt P, Brock M
  Title
The fungal alpha-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.
  Journal
Mol Microbiol 86:1508-30 (2012)
DOI:10.1111/mmi.12076
  Sequence
[sce:YDR234W]
LinkDB

KEGG   ORTHOLOGY: K16792
Entry
K16792                      KO                                     
Symbol
aksD
Name
methanogen homoaconitase large subunit [EC:4.2.1.114]
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Reaction
R03444  (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
R04371  homoisocitrate hydro-lyase
R09720  (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming]
R10391  (R)-(homo)2-citrate hydro-lyase [(-)-threo-iso(homo)2-citrate forming]
R10392  (R)-(homo)2-citrate hydro-lyase
R10393  (-)-threo-iso(homo)2-citrate hydro-lyase
R10394  (R)-(homo)3-citrate hydro-lyase [(-)-threo-iso(homo)3-citrate forming]
R10395  (R)-(homo)3-citrate hydro-lyase
R10396  (-)-threo-iso(homo)3-citrate hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16792  aksD; methanogen homoaconitase large subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16792  aksD; methanogen homoaconitase large subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16792  aksD; methanogen homoaconitase large subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K16792
Other DBs
COG: COG0065
Genes
DLM: DPPLL_22760
NCM: QNK12_15500
ALKG: MOJ78_01920
PLZH: C0638_11390
DBC: MFMK1_002474
SEDM: RBQ61_16875
MMAX: LCQ47_06430
FCZ: IMF26_08905
FBS: N510_000758(hacA)
NAEI: GCM126_09540
AACD: LWP59_12505
RRS: RoseRS_1053
RCA: Rcas_3474
CAU: Caur_0329
CHL: Chy400_0354
CAG: Cagg_3602
HAU: Haur_3302
LEK: hrd7_27860(leuC_2)
KBB: ccbrp13_35940
PMET: G4Y79_18425
DRA: DR_1610
DGE: Dgeo_1156
DDR: Deide_13470
DMR: Deima_1355
DGO: DGo_CA1306
DPD: Deipe_2764
DSW: QR90_09055
DCH: SY84_02060
DPU: SU48_08715
DEZ: DKM44_08505
DWU: DVJ83_05635
DFC: DFI_07080
DEIN: DAAJ005_11930
DGA: DEGR_14160(leuC1)
DPH: EHF33_05185
DRB: N0D28_07410
DAH: DAETH_14730(leuC1)
DAQU: M8445_12290
DTAE: LAJ19_06390
DMB: E5F05_13870
DSC: ABOD76_16825
TRA: Trad_1389
TTH: TT_C1547
TTJ: TTHA1911(TTHA1911)
TTS: Ththe16_1911
TTL: TtJL18_1993
TSC: TSC_c01880(hacA)
THC: TCCBUS3UF1_21070
TOS: Theos_1937
TAQ: TO73_0094
TPAR: AV541_01240
TBC: A0O31_00874
TANT: KNN15_05110
MRB: Mrub_2728
MRE: K649_08895
MTAI: Mtai_v1c23270
MSV: Mesil_0442
OPR: Ocepr_1780
MHD: Marky_0672
SCOR: J3U87_19130
ARAM: KAR29_05985
MJA: MJ_1003
MFE: Mefer_1231
MVU: Metvu_1303
MFS: MFS40622_1618
MIF: Metin_0516
MJH: JH146_0954
MESG: MLAUSG7_0432(hacA)
MESA: MLASG1_0006(hacA)
MIG: Metig_0807
MMP: MMP1480
MMQ: MmarC5_0098
MMX: MmarC6_1194
MMZ: MmarC7_0724
MMD: GYY_08235
MMAK: MMKA1_17030(leuD)
MMAO: MMOS7_15860(leuD)
MMAD: MMJJ_13590(dmdA_1)
MAE: Maeo_0311
MVN: Mevan_0789
MVO: Mvol_1623
MOK: Metok_0062
METF: CFE53_05095
MTH: MTH_1631
MMG: MTBMA_c02160(leuC1)
MWO: MWSIV6_0177(hacA)
MTEE: MTTB_13810
METC: MTCT_1490
METE: tca_01581(dmdA_2)
METZ: METMT2_1470
METK: FVF72_03470
MTHM: FZP57_00775
METJ: FZP68_05785
MST: Msp_1100(leuC2)
METB: AW729_10315
MEIS: PXD04_02105(hacA)
MRU: mru_0384(aksD)
MSI: Msm_0723
MEB: Abm4_0180(aksD)
MMIL: sm9_2161(aksD)
MEYE: TL18_01065
MOL: YLM1_0055
MARO: MarbSA_13800
METV: K4897_04160
MEL: Metbo_2070
MEW: MSWAN_0570
METH: MBMB1_0289(leuC2)
MFC: BRM9_1986(aksD)
MFI: DSM1535_0178(leuC2)
MCUB: MCBB_0567(hacA)
MSUB: BK009_11610
METN: BK008_07185
METT: CIT01_06840
METO: CIT02_05440
MEME: HYG87_07560
MFEG: GCM10025860_11490
MEER: NKF70_09715(hacA)
MFV: Mfer_0965
MKA: MK1208(leuC_2)
MBA: Mbar_A1961
MBY: MSBRM_0704
MBW: MSBRW_2776
MBAR: MSBR2_1672
MBAK: MSBR3_1673
MAC: MA_3085(leuC)
MMA: MM_0409
MMAZ: MmTuc01_0417
MMJ: MSMAS_0894
MMAC: MSMAC_0883
MVC: MSVAZ_1170
MEK: MSKOL_1122
MLS: MSLAZ_2100
METM: MSMTP_2281
MEF: MSWH1_0957
MEQ: MSWHS_1027
MSJ: MSSAC_2956
MSZ: MSSIH_2594
MSW: MSSIT_2634
MTHR: MSTHT_2523
MTHE: MSTHC_0762
MHOR: MSHOH_1131
MFZ: AOB57_002735
MBU: Mbur_2263(hacA)
MMET: MCMEM_0412
MELO: J7W08_00085
MMH: Mmah_0418
MHAZ: BHR79_01390
MPOT: BKM01_07045
MEV: Metev_1371
MZH: Mzhil_0725
MPY: Mpsy_2821
MZI: HWN40_08640
MMAV: RE476_01605
MSEB: RE474_11260
MHZ: Metho_0694
MEHF: MmiHf6_03300(leuC_1)
MEES: MmiEs2_06150(leuC_1)
MTP: Mthe_0788
MCJ: MCON_0444(leuC1)
MHI: Mhar_1525
MHU: Mhun_1800
MRTJ: KHC33_05410
MLA: Mlab_0233
MEM: Memar_0634
MBG: BN140_1717(leuC3)
MEMA: MMAB1_2209(leuC)
MCHK: MchiMG62_07640
MSUM: OH143_09890
MRC: R6Y96_02545
MPI: Mpet_2489
MEND: L6E24_09225
MEFW: F1737_00610
MAQE: RJ40_05980
MFK: E2N92_06110
MOU: OU421_03655
MESB: L1S32_07255
MANQ: L1994_01085
MBN: Mboo_0599
MFO: Metfor_2592
MPL: Mpal_2143
MPD: MCP_1961
MEZ: Mtc_1559(leuC-2)
RCI: RCIX2646(leuC-2)
SSAI: N0B31_20520
MEUZ: KRP56_01645
LOB: NEF87_001443
 » show all
Reference
PMID:18765671
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1003]
LinkDB

KEGG   ORTHOLOGY: K16793
Entry
K16793                      KO                                     
Symbol
aksE
Name
methanogen homoaconitase small subunit [EC:4.2.1.114]
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Reaction
R03444  (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
R04371  homoisocitrate hydro-lyase
R09720  (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming]
R10391  (R)-(homo)2-citrate hydro-lyase [(-)-threo-iso(homo)2-citrate forming]
R10392  (R)-(homo)2-citrate hydro-lyase
R10393  (-)-threo-iso(homo)2-citrate hydro-lyase
R10394  (R)-(homo)3-citrate hydro-lyase [(-)-threo-iso(homo)3-citrate forming]
R10395  (R)-(homo)3-citrate hydro-lyase
R10396  (-)-threo-iso(homo)3-citrate hydro-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16793  aksE; methanogen homoaconitase small subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16793  aksE; methanogen homoaconitase small subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16793  aksE; methanogen homoaconitase small subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K16793
Other DBs
COG: COG0066
Genes
PEW: KZJ38_04415
BOH: AKI39_19115
BGV: CAL12_21875
AHC: JYE49_11640
STUB: MMF93_32380
RRS: RoseRS_1056
RCA: Rcas_3472
CAU: Caur_0330
CHL: Chy400_0355
CAG: Cagg_3601
HAU: Haur_3303
LEK: hrd7_27870(leuD_2)
DRA: DR_1614(leuD)
DGE: Dgeo_1154
DDR: Deide_13460
DMR: Deima_1353
DGO: DGo_CA1308
DPD: Deipe_2762
DSW: QR90_07810
DCH: SY84_02050
DAB: AUC44_07725
DPU: SU48_08705
DEZ: DKM44_08520
DWU: DVJ83_05640
DFC: DFI_07070
DEIN: DAAJ005_09955
DGA: DEGR_14180(leuD1)
DPH: EHF33_03450
DRB: N0D28_11260
DAH: DAETH_14760(leuD1)
DAQU: M8445_12300
DTAE: LAJ19_06385
DMB: E5F05_13860
DSC: ABOD76_16820
TRA: Trad_1390
TTH: TT_C1546
TTJ: TTHA1910(TTHA1910)
TTS: Ththe16_1910
TTL: TtJL18_1992
TSC: TSC_c01890(hacB)
THC: TCCBUS3UF1_21060
TOS: Theos_1936
TAQ: TO73_0095
TPAR: AV541_01245
TBC: A0O31_00873
TANT: KNN15_05115
MRB: Mrub_2727
MRE: K649_08900
MTAI: Mtai_v1c23260
MSV: Mesil_0441
OPR: Ocepr_1781
MHD: Marky_0671
SCOR: J3U87_19135
AMIZ: RBH88_00810
MJA: MJ_1271
MFE: Mefer_0048
MVU: Metvu_0677 Metvu_0864
MFS: MFS40622_0030 MFS40622_0660
MIF: Metin_1437
MJH: JH146_0454
MESG: MLAUSG7_0025(hacB)
MESA: MLASG1_1205(hacB)
MIG: Metig_0050 Metig_1570
MMP: MMP0381
MMQ: MmarC5_1257
MMX: MmarC6_0529
MMZ: MmarC7_1379
MMAK: MMKA1_04000(leuD)
MMAO: MMOS7_03940(leuD)
MMAD: MMJJ_06580(dmdB_1)
MAE: Maeo_0652
MVN: Mevan_1368
MVO: Mvol_1671
MOK: Metok_0567
METF: CFE53_04745
MTH: MTH_829
MMG: MTBMA_c12270(leuD1)
MWO: MWSIV6_1206(hacB)
MTEE: MTTB_05450
METC: MTCT_0743
METE: tca_00796(DmdB_1)
METZ: METMT2_0903
METK: FVF72_07395
MTHM: FZP57_05725
METJ: FZP68_00480
MST: Msp_0374(leuD2)
METB: AW729_05200
MEIS: PXD04_05680(hacB)
MRU: mru_1689(aksE)
MSI: Msm_0847
MEB: Abm4_0514(aksE)
MMIL: sm9_1773(aksE)
MEYE: TL18_07930
MOL: YLM1_1157
MARO: MarbSA_18800
METV: K4897_07245
MEL: Metbo_1944
MEW: MSWAN_0676
METH: MBMB1_0696(leuD1)
MFC: BRM9_1499(aksE)
MFI: DSM1535_2193(leuD1)
MCUB: MCBB_0707(hacB)
MSUB: BK009_01700
METN: BK008_09225
METT: CIT01_01955
METO: CIT02_03290
MEME: HYG87_03480
MFEG: GCM10025860_17660
MEER: NKF70_10465(hacB)
MFV: Mfer_0205
MKA: MK1206(leuD_2)
MBA: Mbar_A0244 Mbar_A2270
MBY: MSBRM_1355 MSBRM_2710
MBW: MSBRW_0751 MSBRW_2476
MBAR: MSBR2_1054 MSBR2_2666
MBAK: MSBR3_1018 MSBR3_2760
MAC: MA_1223(leuC) MA_3751(leuD)
MMA: MM_0645
MMAZ: MmTuc01_0660
MMJ: MSMAS_0664
MMAC: MSMAC_0666
MVC: MSVAZ_0690 MSVAZ_2221
MEK: MSKOL_0668 MSKOL_2220
MLS: MSLAZ_2434
METM: MSMTP_0731
MEF: MSWH1_0826
MEQ: MSWHS_0885
MSJ: MSSAC_3368 MSSAC_3559
MSZ: MSSIH_2894 MSSIH_3101
MSW: MSSIT_2938 MSSIT_3158
MTHR: MSTHT_2374
MTHE: MSTHC_0906
MHOR: MSHOH_0786
MFZ: AOB57_003550
MBU: Mbur_1578
MMET: MCMEM_2089
MELO: J7W08_09410
MMH: Mmah_0127
MHAZ: BHR79_02815
MPOT: BKM01_05485
MEV: Metev_1312
MZH: Mzhil_1660
MPY: Mpsy_2354
MZI: HWN40_10575
MMAV: RE476_12705
MSEB: RE474_09445
MHZ: Metho_0481
MEHF: MmiHf6_03250(dmdB_1)
MEES: MmiEs2_06120(dmdB_1)
MTP: Mthe_0853
MCJ: MCON_1922(leuD1)
MHI: Mhar_2395
MHU: Mhun_1799
MRTJ: KHC33_05415
MLA: Mlab_0234
MEM: Memar_0635
MBG: BN140_1716(leuD3)
MCHK: MchiMG62_07650
MSUM: OH143_09895
MRC: R6Y96_02540
MPI: Mpet_2490
MEFW: F1737_00605
MAQE: RJ40_05975
MFK: E2N92_06105
MOU: OU421_03660
MESB: L1S32_07260
MBN: Mboo_0600
MFO: Metfor_2591
MPL: Mpal_2144
MPD: MCP_1962
MEZ: Mtc_1558(leuD-2)
RCI: RCIX2645(leuD-2)
CDIV: CPM_1676
MEUZ: KRP56_01650 KRP56_05135
 » show all
Reference
PMID:18765671
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1271]
LinkDB

KEGG   REACTION: R04371
Entry
R04371                      Reaction                               
Name
homoisocitrate hydro-lyase
Definition
Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
C05662 <=> C04002 + C00001
Comment
second step of two-step reaction (see R09720, R03444+R04371)
Reaction class
RC00618  C04002_C05662
Enzyme
4.2.1.36        4.2.1.114
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.36
     R04371  Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
    4.2.1.114
     R04371  Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Orthology
K01705  homoaconitate hydratase [EC:4.2.1.36]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
Other DBs
RHEA: 15488
LinkDB

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