Entry
Name
GDP-mannose 4,6-dehydratase;
guanosine 5'-diphosphate-D-mannose oxidoreductase;
guanosine diphosphomannose oxidoreductase;
guanosine diphosphomannose 4,6-dehydratase;
GDP-D-mannose dehydratase;
GDP-D-mannose 4,6-dehydratase;
Gmd;
GDP-mannose 4,6-hydro-lyase;
GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-alpha-D-rhamnose-forming)
Reaction(IUBMB)
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O [RN:
R00888 ]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:
C00096 ]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:
C01222 ];
H2O [CPD:
C00001 ]
Comment
The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-beta-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC
1.1.1.281 , GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6].
History
EC 4.2.1.47 created 1972, modified 2004
Pathway
ec00051 Fructose and mannose metabolism
ec00520 Amino sugar and nucleotide sugar metabolism
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology
K01711 GDPmannose 4,6-dehydratase
Genes
CCAN : 109687854 109687855(Gmds)
XLA : 380044(gmds.L) 444039(gmds.S)
SANH : 107659207(gmds) 107665302
SGH : 107555774(gmds) 107556133
CAUA : 113063182 113096267 113120935
CGIB : 127938782 127984075
ALIM : 106524198 106536316
BFO : 118406178 118417820 118430598
SCLV : 120330242 120330243
DSI : Dsimw501_GD22672(Dsim_GD22672)
AALI : 118463547 118463548
CQU : CpipJ_CPIJ012623 CpipJ_CPIJ012919 CpipJ_CPIJ013547 CpipJ_CPIJ018124 CpipJ_CPIJ018191
CPII : 120416529 120431957
APLN : 108741040 108741065
PPYR : 116159344 116159738 116173898 116174574
DPL : KGM_202722 KGM_213711
CFEL : 113363173 113363691
PTRU : 123502463 123507377
PPOI : 119105715 119105959
LPOL : 106463937 106470496
CEL : CELE_C53B4.7(bre-1) CELE_F56H6.5(gmd-2)
MMER : 128554548 128557871
TAD : TRIADDRAFT_50808 TRIADDRAFT_55349
ATH : AT3G51160(MUR1) AT5G66280(GMD1)
CSAT : 104711656 104727411 104746007 104762946 104780953 104791352
BRP : 103829612 103841032 103855348 103860697 103872569
BNA : 106349038 106358475 106359921 106405977 106416511 106421899 106440111 106448174 125578415 125606640
BOE : 106305407 106305920 106307368 106327896 106344201
RSZ : 108809867 108812417 108813254 108822062 108851440 108855665
MINC : 123199474 123200169
GHI : 107911032 107913008 107920531
DZI : 111292971 111300091 111316258
MSYL : 126588546 126603590
CMAX : 111480638 111482651
CMOS : 111435937 111447684
CPEP : 111806941 111810206
MESC : 110601810 110609213
PALZ : 118029827 118063132
SPEN : 107010610 107014690
SSTN : 125848810 125857605
CANN : 107858281 107862123
NTA : 107776909(GMD) 107810228 107827017 107832048
SSPL : 121769109 121772596
ECAD : 122588198 122588534
LSV : 111894858 111894859 111910835
CCAV : 112512967 112515351
AEW : 130758295 130777693 130777728
NNU : 104588090 104590106 104607483
MING : 122073311 122084417
PSOM : 113288813 113289839
DOSA : Os06t0137700-01(Os06g0137700)
TDC : 119279423 119283696 119287918 119329179
TAES : 123067412 123087889 123150035 123151528 123165694 123169823
LPER : 127311389 127313760
LRD : 124666649 124668886 124698565 124703719 124705108
SBI : 8068417 8069086 8080932 8082498 8082626
PVIR : 120670718 120702535
PDA : 103700075 103716331 120105734
MUS : 103970338 103970359 104000442
ZOF : 121969556 121974688 121977906 122036079 122053355
SMO : SELMODRAFT_443301 SELMODRAFT_99252
PPP : 112282887 112283572 112291215 112294378
ABP : AGABI1DRAFT114673(AGABI1DRAFT_114673)
ABV : AGABI2DRAFT194857(AGABI2DRAFT_194857)
SCM : SCHCO_02628332(SCHCODRAFT_02628332)
DFA : DFA_03372 DFA_09877(gmd)
PREL : PRELSG_1423700(GMD)
SMIN : v1.2.022459.t1(symbB.v1.2.022459.t1)
PTI : PHATRDRAFT_25417(GMD1)
FCY : FRACYDRAFT_206067(GMD1)
TPS : THAPSDRAFT_40586(GMD1)
AAF : AURANDRAFT_23507 AURANDRAFT_33270
EHX : EMIHUDRAFT_310372 EMIHUDRAFT_434640
NGR : NAEGRDRAFT_35594 NAEGRDRAFT_60943 NAEGRDRAFT_60947
ECS : ECs_2839(gmd) ECs_2858(gmd)
ECF : ECH74115_2968(gmd) ECH74115_2988(gmd)
ETW : ECSP_2789(gmd1) ECSP_2808(gmd2)
ELX : CDCO157_2618 CDCO157_2638
EOI : ECO111_2765 ECO111_2772(gmd)
ECOO : ECRM13514_2774(gmd)
ECOH : ECRM13516_2644(gmd)
ECG : E2348C_2180 E2348C_2195(gmd)
EOK : G2583_2562(gmd) G2583_2576(gmd)
ELR : ECO55CA74_12325 ECO55CA74_12395
EDJ : ECDH1ME8569_1990(gmd)
EFE : EFER_2118(gmd) EFER_2137(gmd)
SEEC : CFSAN002050_17410 CFSAN002050_17480
CYO : CD187_08885(gmd) CD187_08955(gmd)
CPOT : FOB25_20170(gmd) FOB25_20265(gmd)
CIF : AL515_09720(gmd) AL515_09810(gmd)
CTEL : GBC03_13960(gmd) GBC03_14045(gmd)
CITZ : E4Z61_02495(gmd) E4Z61_02595(gmd)
CARS : E1B03_16975(gmd) E1B03_17070(gmd)
CLAP : NCTC11466_01498(gmd)
KOT : EH164_08030(gmd) EH164_08105(gmd)
KIE : NCTC12125_00606(gmd)
BAGE : BADSM9389_14820(gmd) BADSM9389_14990
AHN : NCTC12129_03346(gmd_2) NCTC12129_03367(gmd_3)
ASUB : NLZ15_07705(gmd) NLZ15_07790(gmd)
METY : MRY16398_17880(gmd)
YPP : YPDSF_2740 YPDSF_2741
YPT : A1122_10440 A1122_10445
YPI : YpsIP31758_3041(gmd)
YMO : HRD69_10910(gmd) HRD69_10940(gmd)
SLQ : M495_07470 M495_07565
SERA : Ser39006_009850(gmd) Ser39006_021540(gmd)
SERQ : CWC46_09845(gmd) CWC46_21550(gmd)
RAQ : Rahaq2_0609 Rahaq2_3675
ROX : BV494_12815 BV494_19825
PROD : PCO85_03915(gmd) PCO85_15550(gmd)
XFU : XFF4834R_chr34900(gmd)
XPH : XppCFBP6546_16345(gmd)
LSX : H8B22_03660 H8B22_03680(gmd)
TCN : H9L16_11390 H9L16_11410(gmd)
DJI : CH75_02380 CH75_02400
PAVL : BKM03_05920(gmd) BKM03_06235(gmd)
PPRC : PFLCHA0_c19710(gmd)
PRX : HRH33_09160 HRH33_09165(gmd)