Entry
Name
GDP-mannose 4,6-dehydratase;
guanosine 5'-diphosphate-D-mannose oxidoreductase;
guanosine diphosphomannose oxidoreductase;
guanosine diphosphomannose 4,6-dehydratase;
GDP-D-mannose dehydratase;
GDP-D-mannose 4,6-dehydratase;
Gmd;
GDP-mannose 4,6-hydro-lyase;
GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-alpha-D-rhamnose-forming)
Reaction(IUBMB)
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O [RN:
R00888 ]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:
C00096 ]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:
C01222 ];
H2O [CPD:
C00001 ]
Comment
The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-beta-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC
1.1.1.281 , GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6].
History
EC 4.2.1.47 created 1972, modified 2004
Pathway
ec00051 Fructose and mannose metabolism
ec00520 Amino sugar and nucleotide sugar metabolism
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology
K01711 GDPmannose 4,6-dehydratase
Genes
CCAN : 109687854 109687855(Gmds)
XLA : 380044(gmds.L) 444039(gmds.S)
SANH : 107659207(gmds) 107665302
SGH : 107555774(gmds) 107556133
CAUA : 113063182 113096267 113120935
ALIM : 106524198 106536316
BFO : 118406178 118417820 118430598
SCLV : 120330242 120330243
DSI : Dsimw501_GD22672(Dsim_GD22672)
CQU : CpipJ_CPIJ012623 CpipJ_CPIJ012919 CpipJ_CPIJ013547 CpipJ_CPIJ018124 CpipJ_CPIJ018191
CPII : 120416529 120431957
APLN : 108741040 108741065
PPYR : 116159344 116159738 116173898 116174574
DPL : KGM_202722 KGM_213711
PTRU : 123502463 123507377
CEL : CELE_C53B4.7(bre-1) CELE_F56H6.5(gmd-2)
TAD : TRIADDRAFT_50808 TRIADDRAFT_55349
ATH : AT3G51160(MUR1) AT5G66280(GMD1)
CSAT : 104711656 104727411 104746007 104762946 104780953 104791352
BRP : 103829612 103841032 103855348 103860697 103872569
BNA : 106349038 106358475 106359921 106361857 106367717 106405977 106416511 106421899 106440111 106448174
BOE : 106305407 106305920 106307368 106327896 106344201
RSZ : 108809867 108812417 108813254 108822062 108851440 108855665
MINC : 123199474 123200169
GHI : 107911032 107913008 107920531
DZI : 111292971 111300091 111316258
MTR : MTR_5g021760 MTR_5g021770
CMAX : 111480638 111482651
CMOS : 111435937 111447684
CPEP : 111806941 111810206
MESC : 110601810 110609213
PALZ : 118029827 118063132
SPEN : 107010610 107014690
CANN : 107858281 107862123
NTA : 107776909(GMD) 107810228 107827017 107832048
SSPL : 121769109 121772596
ECAD : 122588198 122588534
LSV : 111894858 111894859 111910835
CCAV : 112512967 112515351
NNU : 104588090 104590106 104607483
MING : 122073311 122084417
PSOM : 113288813 113289839
DOSA : Os06t0137700-01(Os06g0137700)
TDC : 119279423 119283696 119287918 119329179
TAES : 123067412 123087889 123150035 123151528 123165694 123169823
SBI : 8068417 8069086 8080932 8082498 8082626
PVIR : 120670718 120702535
PDA : 103700075 103716331 120105734
MUS : 103970338 103970359 104000442
SMO : SELMODRAFT_443301 SELMODRAFT_99252
PPP : 112282887 112283572 112291215 112294378
ABP : AGABI1DRAFT114673(AGABI1DRAFT_114673)
ABV : AGABI2DRAFT194857(AGABI2DRAFT_194857)
DFA : DFA_03372 DFA_09877(gmd)
PCB : PCHAS_142550(PC000770.03.0)
SMIN : v1.2.022459.t1(symbB.v1.2.022459.t1)
PTI : PHATRDRAFT_25417(GMD1)
FCY : FRACYDRAFT_206067(GMD1)
TPS : THAPSDRAFT_40586(GMD1)
AAF : AURANDRAFT_23507 AURANDRAFT_33270
EHX : EMIHUDRAFT_310372 EMIHUDRAFT_434640
NGR : NAEGRDRAFT_35594 NAEGRDRAFT_60943 NAEGRDRAFT_60947
ECS : ECs_2839(gmd) ECs_2858(gmd)
ECF : ECH74115_2968(gmd) ECH74115_2988(gmd)
ETW : ECSP_2789(gmd1) ECSP_2808(gmd2)
ELX : CDCO157_2618 CDCO157_2638
EOI : ECO111_2765 ECO111_2772(gmd)
ECOO : ECRM13514_2774(gmd)
ECOH : ECRM13516_2644(gmd)
ECG : E2348C_2180 E2348C_2195(gmd)
EOK : G2583_2562(gmd) G2583_2576(gmd)
ELR : ECO55CA74_12325 ECO55CA74_12395
EDJ : ECDH1ME8569_1990(gmd)
EFE : EFER_2118(gmd) EFER_2137(gmd)
SEEC : CFSAN002050_17410 CFSAN002050_17480
CYO : CD187_08885(gmd) CD187_08955(gmd)
CPOT : FOB25_20170(gmd) FOB25_20265(gmd)
CIF : AL515_09720(gmd) AL515_09810(gmd)
CTEL : GBC03_13960(gmd) GBC03_14045(gmd)
CITZ : E4Z61_02495(gmd) E4Z61_02595(gmd)
CARS : E1B03_16975(gmd) E1B03_17070(gmd)
CLAP : NCTC11466_01498(gmd)
KOT : EH164_08030(gmd) EH164_08105(gmd)
KIE : NCTC12125_00606(gmd)
BAGE : BADSM9389_14820(gmd) BADSM9389_14990
METY : MRY16398_17880(gmd)
AHN : NCTC12129_03346(gmd_2) NCTC12129_03367(gmd_3)
YPP : YPDSF_2740 YPDSF_2741
YPT : A1122_10440 A1122_10445
YPI : YpsIP31758_3041(gmd)
YMO : HRD69_10910(gmd) HRD69_10940(gmd)
SLQ : M495_07470 M495_07565
SERA : Ser39006_009850(gmd) Ser39006_021540(gmd)
SERQ : CWC46_09845(gmd) CWC46_21550(gmd)
RAQ : Rahaq2_0609 Rahaq2_3675
ROX : BV494_12815 BV494_19825
XFU : XFF4834R_chr34900(gmd)
XPH : XppCFBP6546_16345(gmd)
LSX : H8B22_03660 H8B22_03680(gmd)
TCN : H9L16_11390 H9L16_11410(gmd)
DJI : CH75_02380 CH75_02400
PAVL : BKM03_05920(gmd) BKM03_06235(gmd)
PPRC : PFLCHA0_c19710(gmd)
PRX : HRH33_09160 HRH33_09165(gmd)
PSTT : CH92_06065 CH92_12745
PSK : U771_09400 U771_13285
PRH : LT40_08540 LT40_09350
PNN : KEM63_05625(gmd) KEM63_14840(gmd)
SVO : SVI_1471(gmd-1) SVI_1477(gmd-2) SVI_1478(gmd-3)
SALM : D0Y50_03415(gmd) D0Y50_16670(gmd)
AGZ : M0C34_07330(gmd) M0C34_18890(gmd)
CBS : COXBURSA331_A0807(gmd)
LWA : SAMEA4504053_1118(gmd)
LANT : TUM19329_13100(gmd)
TMC : LMI_3103(gca) LMI_3129(gmd)
MPAD : KEF85_00515(gmd) KEF85_11845(gmd)
MMOB : F6R98_19090(gmd) F6R98_19095
MISZ : MishRS11D_15800(gmd)
MESL : KKZ03_04310 KKZ03_10140(gmd)
TSY : THSYN_25095 THSYN_28750
CJAP : GWK36_00885 GWK36_00890(gmd)
THIM : KFB96_06460 KFB96_24090(gmd)
MME : Marme_0625 Marme_2110
ACII : C4901_06690(gmd) C4901_06695
NBA : CUN60_04495(gmd) CUN60_12805(gmd)
REH : H16_A2900(h16_A2900)
CBW : RR42_s0033 RR42_s2604 RR42_s2868
BMA : BMA2297 BMAA1709(gmd)
BMV : BMASAVP1_1660(gmd) BMASAVP1_A0531
BMN : BMA10247_2175 BMA10247_A0540(gmd)
BPS : BPSL2797(wcbK) BPSS1688(gca)
BPM : BURPS1710b_A0758(gmd)
BPL : BURPS1106A_3279 BURPS1106A_A2295(gmd)
BTE : BTH_I1331(gmd-1) BTH_II0690(gmd-2)
BTQ : BTQ_2603(gmd) BTQ_3982(gmd)
BTJ : BTJ_3092(gmd) BTJ_5014(gmd)
BTZ : BTL_1022(gmd) BTL_3482(gmd)
BTD : BTI_4200(gmd) BTI_802(gmd)
BTV : BTHA_1115(gmd) BTHA_4403(gmd)
BTHE : BTN_365(gmd) BTN_5469(gmd)
BTHM : BTRA_1230(gmd) BTRA_3478(gmd)
BTHL : BG87_1219(gmd) BG87_3437(gmd)
BOK : DM82_2470(gmd) DM82_5937(gmd)
BOC : BG90_2264(gmd) BG90_2397(gmd) BG90_4701(gmd)
BUU : WS70_23515 WS70_25595
BSAV : WS86_04205 WS86_27340
BVI : Bcep1808_4472 Bcep1808_6523
BVE : AK36_4365(gmd) AK36_5970(gmd)
BCH : Bcen2424_0880 Bcen2424_3970
BCEN : DM39_3952(gmd) DM39_690(gmd)
BCEW : DM40_1543(gmd) DM40_3970(gmd)
BAC : BamMC406_0770 BamMC406_3863
BMK : DM80_3815(gmd) DM80_796(gmd)
BDL : AK34_2294(gmd) AK34_4460(gmd)
BPYR : ABD05_09445 ABD05_16785
BCON : NL30_07350 NL30_11350
BUB : BW23_4730(gmd) BW23_853(gmd)
BDF : WI26_03900 WI26_18610
BLAT : WK25_04130 WK25_22420
BSEM : WJ12_04020 WJ12_25280
BPSL : WS57_08765 WS57_16265
BMEC : WJ16_04055 WJ16_23950
BSTG : WT74_04345 WT74_24285
BANN : JFN94_04195(gmd) JFN94_22585(gmd)
BGL : bglu_1g06550 bglu_2g08510
BGU : KS03_1584(gmd) KS03_5065(gmd)
BUG : BC1001_0523 BC1001_1649
BGF : BC1003_0550 BC1003_1679
BGD : bgla_1g06980 bgla_2g18030
BGO : BM43_2087(gmd) BM43_5521(gmd)
BUL : BW21_3740(gmd) BW21_898(gmd)
BUQ : AC233_02915 AC233_08190
BGP : BGL_1c06370(gmd) BGL_2c17920(gmd)
BPLA : bpln_1g06290 bpln_2g18690
BUD : AQ610_03885 AQ610_22200
BUM : AXG89_01930 AXG89_02435
BUI : AX768_11660 AX768_12145
BURK : DM992_17210(gmd) DM992_30725(gmd)
BXE : Bxe_A2234 Bxe_A3863 Bxe_C1085
BXB : DR64_1539(gmd) DR64_4385(gmd) DR64_8715(gmd)
BPH : Bphy_1069 Bphy_2471 Bphy_6734
BPX : BUPH_02165 BUPH_04408
BPY : Bphyt_0821 Bphyt_1965
BUZ : AYM40_02970 AYM40_10795
BFN : OI25_3563(gmd) OI25_876(gmd)
BCAI : K788_0004491 K788_0004889
PSPW : BJG93_05000(gmd) BJG93_27060(gmd)
PARA : BTO02_07035 BTO02_11930 BTO02_24965
PARB : CJU94_02150(gmd) CJU94_15165(gmd)
PHS : C2L64_08485(gmd) C2L64_14855(gmd)
PTER : C2L65_07945(gmd) C2L65_12155(gmd) C2L65_12775(gmd)
PGP : CUJ91_03030(gmd) CUJ91_08805(gmd)
PCJ : CUJ87_02775(gmd) CUJ87_08010(gmd)
PTS : CUJ90_02910(gmd) CUJ90_08630(gmd)
PCAF : DSC91_006002 DSC91_007444
PTRO : G5S35_02330(gmd) G5S35_14815(gmd)
PGIS : I6I06_04180(gmd) I6I06_08460(gmd) I6I06_08485(gmd)
PACP : FAZ97_02395(gmd) FAZ97_03285(gmd) FAZ97_03335(gmd)
PACS : FAZ98_02285(gmd) FAZ98_16980(gmd)
PEW : KZJ38_10760(gmd) KZJ38_16165(gmd) KZJ38_16170 KZJ38_26935(gmd)
PDQ : CL55_00002910 CL55_00003080 CL55_00003100
PLG : NCTC10937_04689(gmd_2)
CABA : SBC2_28140(gmd_1) SBC2_29070(gmd_2)
BUO : BRPE64_ACDS21650 BRPE64_DCDS10740
AXX : ERS451415_04359(gmd)
RHY : RD110_07050 RD110_10045
RHG : EXZ61_14260 EXZ61_14285(gmd) EXZ61_18990
CPRA : CPter91_0942(gmd) CPter91_3973(gca)
MASW : AM586_08590 AM586_25160
RGE : RGE_41260(gmd) RGE_41600(gmd)
PKT : AT984_02230 AT984_13640
RGU : A4W93_23470 A4W93_23480
AON : DEH84_14135(gmd) DEH84_14175(gmd)
SNN : EWH46_12250(gmd) EWH46_14175(gmd)
IDC : LRM40_01370(gmd) LRM40_05375(gmd)
MEP : MPQ_0112(gmd) MPQ_0116
NIM : W01_08540(rfbD) W01_08550(gmd_1) W01_22150(gmd_2)
SNIV : SFSGTM_06230(gmd_1) SFSGTM_06280(gmd_2)
URU : DSM104443_02811(gmd)
UPL : DSM104440_03320(gmd_1) DSM104440_03321(gmd_2)
APET : ToN1_17490(gmd1) ToN1_17510(gmd2)
AZA : AZKH_0238(gmd) AZKH_0239(gmd)
FMY : HO273_05120(gmd) HO273_05125
BPRC : D521_0308 D521_0309 D521_0320(gmd)
HPO : HMPREF4655_21538(gmd)
HPI : hp908_0046(gmd1) hp908_0047(gmd2)
HPX : HMPREF0462_1360(gmd)
HTY : BN2458_PEG0547 BN2458_PEG0800
HCL : NCTC13205_00588(gmd)
HSH : NHP194022_10910(gmd)
SULR : B649_08610 B649_09955
AVP : AVENP_1999 AVENP_2930
SLH : YH65_02380 YH65_07120
GME : Gmet_1311(gmd-1) Gmet_1488(gmd-2)
GEM : GM21_2591 GM21_2604 GM21_3149
GPI : GPICK_10405 GPICK_13225 GPICK_13285
GEF : FO488_01080(gmd) FO488_13845
GUR : Gura_3210 Gura_3780 Gura_3801
GSUB : KP001_03170(gmd) KP001_20290(gmd)
DMA : DMR_26790(gmd) DMR_26800(gmd)
DCB : C3Y92_12405(gmd) C3Y92_12410
DMS : E8L03_01185(gmd) E8L03_12970(gmd)
DBA : Dbac_2561 Dbac_3251 Dbac_3269
DTO : TOL2_C14070(gca) TOL2_C14080(gmd) TOL2_C35370(gmd2)
DOV : DSCO28_38440(gmd) DSCO28_64550
DALK : DSCA_09690(gmd_1) DSCA_09790(gmdA) DSCA_23350(gmd_2)
MERD : EB233_10055(gmd) EB233_24840(gmd) EB233_31080(gmd)
RBS : RHODOSMS8_03428(gmd)
SFD : USDA257_c10690(noeL)
RET : RHE_CH00762(noeL1) RHE_CH01350(noeL2)
REC : RHECIAT_CH0000849(noeLch) RHECIAT_PC0000279(noeLc)
REL : REMIM1_CH00794(noeL-1) REMIM1_CH01359(noeL-2)
REP : IE4803_CH00794(noeL-1) IE4803_PD00373(noeL-2)
REI : IE4771_CH00817(noeL-1) IE4771_PE00388(noeL-2)
RLE : RL0825(gmd) pRL90133
RLT : Rleg2_0425 Rleg2_6433
RLB : RLEG3_00380 RLEG3_12185
RTR : RTCIAT899_CH18290(gmd)
RPUS : CFBP5875_22115(gmd)
RHN : AMJ98_CH00806(noeL-1) AMJ98_CH01390(noeL-2)
RPHA : AMC79_CH00811(noeL-1) AMC79_PD00301(noeL-2)
RHX : AMK02_CH00809(noeL-1) AMK02_CH01395(noeL-2)
RHK : Kim5_CH00875(noeL-1) Kim5_PD00349(noeL-2)
REZ : AMJ99_CH00806(noeL-1) AMJ99_CH01469(noeL-2)
RAD : CO657_02205(gmd) CO657_32920(gmd)
RII : FFM53_009015(gmd) FFM53_034515(gmd)
RHID : FFM81_017090(gmd) FFM81_028250(gmd)
RBQ : J2J99_04125(gmd) J2J99_33025(gmd)
RLN : J0663_12620(gmd) J0663_15650(gmd)
RBAN : J2J98_03835(gmd) J2J98_06760(gmd)
RRG : J3P73_04750(gmd) J3P73_04780 J3P73_32285(gmd)
NGL : RG1141_CH11610(bme9)
BMEL : DK63_2075(gmd) DK63_2400(gmd)
BMI : BMEA_A0560(gmd) BMEA_B0397(gmd)
BMZ : BM28_A0536 BM28_B0392
BMG : BM590_A0538 BM590_B0390
BMW : BMNI_I0530 BMNI_II0383
BMEE : DK62_3007(gmd) DK62_879(gmd)
BSI : BS1330_I0521(gmd) BS1330_II0416
BSF : BSS2_I0509(gmd) BSS2_II0400
BSUI : BSSP1_I1184 BSSP1_II0375(gmd)
BSUP : BSPT1_I1195 BSPT1_II0373(gmd)