Entry
Name
ornithine cyclodeaminase;
ornithine cyclase;
ornithine cyclase (deaminating);
L-ornithine ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
Reaction(IUBMB)
L-ornithine = L-proline + NH3 [RN:
R00671 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires NAD+. The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2].
History
EC 4.3.1.12 created 1976
Pathway
ec00330 Arginine and proline metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K01750 ornithine cyclodeaminase
Genes
PCQ : PcP3B5_20880(rapL_2)
PPG : PputGB1_1891 PputGB1_2392
PIX : RIN61_08375 RIN61_20690
PPRC : PFLCHA0_c36820(arcB1)
PFW : PF1751_v1c34300(arcB)
PSEC : CCOS191_1758(arcB2)
PSJY : AA098_12095 AA098_17940
PSKP : KU43P_36400(arcB_2)
CBS : COXBURSA331_A1919(arcB)
GAI : IMCC3135_33495(rapL)
REH : H16_A0689(h16_A0689)
CBW : RR42_m0815 RR42_s1855
CPAU : EHF44_02455 EHF44_14210
BUR : Bcep18194_B2542 Bcep18194_B2946
BSTG : WT74_21255 WT74_22065
BAEN : L3V59_30470 L3V59_32700
BGO : BM43_2894 BM43_4121 BM43_6554
PCAF : DSC91_000487 DSC91_007361
PMEG : FNZ07_03115 FNZ07_12515
TVL : FAZ95_22360 FAZ95_30835
BTRM : SAMEA390648701743(arcB)
RHOA : HZ993_16670 HZ993_20070
ACID : CBP33_11605 CBP33_16305
LIM : L103DPR2_01265(rapL)
LIH : L63ED372_00198(rapL)
SMIO : CATMQ487_32490(ocd_1) CATMQ487_40770(ocd_2)
MCI : Mesci_2494 Mesci_5621
MOP : Mesop_3028 Mesop_6204
MAM : Mesau_02624 Mesau_02786 Mesau_05673
MESW : A9K65_013045 A9K65_030505
MESP : C1M53_04775 C1M53_19735
PHT : BLM14_26880 BLM14_28535
SFD : USDA257_c14360(arcB1)
SAME : SAMCFNEI73_pC1311(arcB)
EAH : FA04_22405 FA04_28080
ATF : Ach5_37900(ocd) Ach5_51550
ALF : CFBP5473_20470 CFBP5473_23915
AVF : RvVAR031_32460 RvVAR031_pl05760(arcB)
ASAL : CFBP5507_18915 CFBP5507_27340
ALEG : CFBP4996_21170 CFBP4996_25895(ocd) CFBP4996_28650(ocd)
RHL : LPU83_pLPU83c0744(arcB)
ROY : G3A56_21215 G3A56_22235
ARA : Arad_10025(ocdch2) Arad_14151
ARO : B0909_17715 B0909_19190
NEN : NCHU2750_47100(ocd) NCHU2750_55520(ocd)
BIO : BR141012304_20120(arcB)
OPS : A8A54_07600 A8A54_10655
OCC : KMS41_07985 KMS41_18620
OCH : CES85_1840 CES85_5141
PSF : PSE_0777(arcB) PSE_2943(arcB)
RLI : RLO149_c033720(arcB)
PHP : PhaeoP97_01647(arcB)
PPIC : PhaeoP14_01541(arcB)
OAT : OAN307_c23960(arcB2)
SPOT : G6548_09160 G6548_16485
SINL : DSM14862_01269(ocd)
SULB : IV89_000172 IV89_001894
SPSE : SULPSESMR1_01739(arcB)
ROM : EI983_07450 EI983_15425
LALG : LentiSH36_01386(arcB_2)
PARU : CYR75_05535 CYR75_15485
PSEW : JHW44_01195 JHW44_15845
LVS : LOKVESSMR4R_01472(arcB)
YRH : AABB31_01240 AABB31_14095
SINR : O5O51_00225 O5O51_05555
RCP : RCAP_rcc02113(arcB1)
GAL : A0U94_03395 A0U94_12435
ECOG : FIV45_03025 FIV45_07905
MSUW : GCM10025863_17010(ocd)
AMAU : DSM26151_19720(ocd)
BRV : CFK39_11375 CFK39_11395
BRZ : CFK38_16100 CFK38_16135
DSS : GCM25873_17060(ocd1)
» show all
Taxonomy
Reference
Authors
Costilow RN, Laycock L.
Title
Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions.
Journal
J Biol Chem 246:6655-60 (1971)
Reference
Authors
Muth WL, Costilow RN.
Title
Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme.
Journal
J Biol Chem 249:7457-62 (1974)
Reference
Authors
Espineda CE, Linford AS, Devine D, Brusslan JA.
Title
The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana.
Journal
Reference
Authors
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE
Title
Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.
Journal
Sequence
Reference
Authors
Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE.
Title
Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.12
ExPASy - ENZYME nomenclature database: 4.3.1.12
LinkDB
All DBs