KEGG   ORTHOLOGY: K01750
Entry
K01750                      KO                                     
Symbol
E4.3.1.12, ocd
Name
ornithine cyclodeaminase [EC:4.3.1.12]
Pathway
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
Reaction
R00671  L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K01750  E4.3.1.12, ocd; ornithine cyclodeaminase
Enzymes [BR:ko01000]
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.12  ornithine cyclodeaminase
     K01750  E4.3.1.12, ocd; ornithine cyclodeaminase
Other DBs
COG: COG2423
GO: 0008473
Genes
KPAS: LUW96_28450
SFJ: SAMEA4384070_0399
RCB: O1V66_04900
EBI: EbC_pEb10200380
RPNE: NCTC8284_02732
RHAE: IHV77_05160
LLZ: LYB30171_01152(ocd)
RGL: CS053_10430
XBA: C7S18_00305
VNA: PN96_18395
PCQ: PcP3B5_20880(rapL_2)
PPU: PP_3533
PPF: Pput_2240
PPT: PPS_2421
PPI: YSA_00067
PPX: T1E_0019(arcB)
PPUH: B479_09255
PPUT: L483_18510
PPUN: PP4_23000
PPUD: DW66_2681
PMON: X969_07215
PMOT: X970_07190
PFL: PFL_3641(arcB)
PPRC: PFLCHA0_c36820(arcB1)
PPRO: PPC_3781
PFS: PFLU_3970
PFC: PflA506_3344(arcB)
PFB: VO64_1052
PFW: PF1751_v1c34300(arcB)
PEN: PSEEN1859(arcB)
PSEC: CCOS191_1758(arcB2)
PSOS: POS17_3783
PANR: A7J50_3626
PSIL: PMA3_14245
PDW: BV82_1074
PSKP: KU43P_36400(arcB_2)
PALI: A3K91_2015
PHA: PSHAb0543
PTN: PTRA_b0777(ocd)
PEA: PESP_b0847(ocd)
PNG: PNIG_b0727(ocd)
PAGA: PAGA_b0945(ocd)
PSMM: PspMM1_37860(ocd)
MVS: MVIS_1158(arcB)
MYA: MORIYA_4287(ocd)
CBU: CBU_1727(arcB)
CBS: COXBURSA331_A1919(arcB)
CBD: CBUD_0275(arcB)
CBG: CbuG_0108(arcB)
CBC: CbuK_0280(arcB)
CEY: CleRT_01960(arcB)
MAH: MEALZ_0771(arcB)
FTW: FTW_0394
FTL: FTL_0578
FTA: FTA_0612
FTS: F92_03155
FTC: DA46_105
FTV: CH67_891
FTZ: CH68_625
FTN: FTN_1444
FTX: AW25_557
FTD: AS84_1058
FTY: CH70_486
FPH: Fphi_1230
FPT: BZ13_774
FPI: BF30_1477
FPM: LA56_960
FPX: KU46_82
FPZ: LA55_1680
FPJ: LA02_848
FNA: OOM_0787
FRC: KX01_1779
GAI: IMCC3135_33495(rapL)
ADI: B5T_03949(arcB)
AXE: P40_19150
RSO: RSp0483
RSE: F504_3884
RSL: RPSI07_mp0417(arcB)
RSN: RSPO_m00318(arcB)
RSM: CMR15_mp10460(arcB)
RSY: RSUY_37340(rapL_3)
REH: H16_A0689(h16_A0689)
CNC: CNE_1c06810(arcB1)
RME: Rmet_0586(arcB)
CGD: CR3_2039
BOK: DM82_5356
BOC: BG90_5252
BSAV: WS86_29670
BCJ: BCAM0604
BCEN: DM39_4558
BCEO: I35_4500
BAM: Bamb_5311
BCT: GEM_5158
BCED: DM42_4486
BCON: NL30_22780
BUB: BW23_4328
BTEI: WS51_01570
BSEM: WJ12_23010
BPSL: WS57_10850
BMEC: WJ16_22040
BGP: BGL_1c14730(arcB)
CABA: SBC2_69380(ocd_2)
BPT: Bpet0748
BAV: BAV0458(arcB)
BHZ: ACR54_00645(rapL_1)
BTRM: SAMEA390648701743(arcB)
AXY: AXYL_00273(arcB)
TEA: KUI_0789(arcB)
TEG: KUK_0627(arcB)
TAS: TASI_0895
TAT: KUM_0109(arcB)
AMIM: MIM_c40550(arcB)
BPSI: IX83_00315
RFR: Rfer_3883
POL: Bpro_4602
PNA: Pnap_3771
PVAC: HC248_00245(ocd_1)
AJS: Ajs_0613
ACRA: BSY15_1884
ACIQ: ACDW_39420
AAV: Aave_0121
AAA: Acav_0154
DAC: Daci_0682
VPD: VAPA_1c48470(arcB)
CTES: O987_24910
CTEZ: CT3_15090(ocd1)
LIM: L103DPR2_01265(rapL)
LIH: L63ED372_00198(rapL)
HYR: BSY239_28
HPSE: HPF_05975(rapL)
SMIO: CATMQ487_32490(ocd_1) CATMQ487_40770(ocd_2)
LCH: Lcho_0279
UND: UNDKW_0988(arcB)
UNY: UNDYM_0976(arcB)
APET: ToN1_36090
AZA: AZKH_3290(ocd-2)
MLO: mll6776
MHUA: MCHK_0400
MESJ: MJ8_63530
MES: Meso_3962
AMIS: Amn_53340
SME: SM_b21494(ocd)
SMX: SM11_pD0294(ocd)
SMI: BN406_05372(arcB)
SMEL: SM2011_b21494(ocd)
SMER: DU99_26935
RHI: NGR_b18880(ocd1)
SFH: SFHH103_05325(ocd1)
SFD: USDA257_c14360(arcB1)
SAME: SAMCFNEI73_pC1311(arcB)
EAD: OV14_a0459(ocd1)
ATU: Atu6016(ocd)
RIR: BN877_II1136(arcB)
AVI: Avi_5979(ocd)
RLE: RL3095(arcB1)
RHL: LPU83_pLPU83c0744(arcB)
ARA: Arad_10025(ocdch2) Arad_14151
RHT: NT26_3751(arcB)
SHZ: shn_29375
SZO: K8M09_20750(ocd)
KAI: K32_10430
BME: BMEII0397
BMEL: DK63_2841
BMEE: DK62_2556
BMF: BAB2_0338
BMB: BruAb2_0334(arcB)
BABO: DK55_2329
BABR: DO74_2749
BABT: DK49_2903
BABB: DK48_2362
BABU: DK53_2339
BABS: DK51_2918
BABC: DO78_2721
BMS: BRA0899(arcB)
BSI: BS1330_II0891(arcB)
BSF: BSS2_II0851(arcB)
BSZ: DK67_2852
BSV: BSVBI22_B0890(arcB)
BOV: BOV_A0842(arcB)
BCS: BCAN_B0918(arcB)
BOL: BCOUA_II0899(arcB)
BCAR: DK60_2589
BCAS: DA85_14770
BMR: BMI_II893(arcB)
BPP: BPI_II955(arcB)
BPV: DK65_2752
BCET: V910_200393(arcB)
BCEE: V568_200442(arcB)
BVL: BF3285c2_0422(arcB)
BIO: BR141012304_20120(arcB)
OAN: Oant_1471
OAH: DR92_1038
MEA: Mex_1p3003(arcB)
MDI: METDI3569(arcB)
MEX: Mext_2802
MCH: Mchl_3030
MPO: Mpop_2926
MET: M446_1826
MNO: Mnod_1216
META: Y590_13520
MIND: mvi_29560
MECL: CLZ_12815
BBAR: RHAL1_02560(ocd)
MSC: BN69_2878
PLEO: OHA_1_00570(rapL)
THD: BHV28_07820(arcb3)
PSF: PSE_0777(arcB) PSE_2943(arcB)
LABT: FIU93_05740(rapL2)
SIL: SPO2121(arcB)
RUT: FIU92_06215(rapL1)
RDE: RD1_1415(arcB)
RLI: RLO149_c033720(arcB)
RFU: ROLI_022290(ocd)
DSH: Dshi_2310
PGA: PGA1_c16390(arcB)
PGL: PGA2_c16220(arcB)
PGD: Gal_01704
PHP: PhaeoP97_01647(arcB)
PPIC: PhaeoP14_01541(arcB)
OAT: OAN307_c23960(arcB2)
OAR: OA238_c21340(arcB)
OTM: OSB_15220(rapL_3)
LAQU: R2C4_08710
CID: P73_4323
MALG: MALG_01627
SINL: DSM14862_01269(ocd)
SPSE: SULPSESMR1_01739(arcB)
ROH: FIU89_08840(rapL3)
ROT: FIV09_11025(rapL2)
LALG: LentiSH36_01386(arcB_2)
MARU: FIU81_06900(rapL2)
PDE: Pden_4637
PAMN: pAMV3p0337(arcB)
PMAU: CP157_00500(ocd)
PTP: RCA23_c24410(arcB)
LVS: LOKVESSMR4R_01472(arcB)
PAMO: BAR1_08715
RCP: RCAP_rcc02113(arcB1)
SMAZ: LH19_02825
SWI: Swit_1052
SPHD: HY78_21245
SPHI: TS85_10390
GOY: GLS_c16230(arcB)
AMV: ACMV_19460(arcB)
AZL: AZL_b04900(ocd)
ALI: AZOLI_p20520(ocd)
TMO: TMO_a0011
ALK: ALEK_1697(arcB)
CBL: CLK_0333
CLD: CLSPO_c08830(arcB1)
CAR: cauri_1343(arcB)
CRD: CRES_0238(arcB)
CCJ: UL81_05640(arcB)
CGV: CGLAU_07290(rapL)
CACC: CACC_05965(rapL)
CJH: CJEDD_07415(rapL)
CMAS: CMASS_04995(rapL)
CCOY: CCOY_07320(rapL)
CCOU: CCONF_05655(rapL)
MSUW: GCM10025863_17010(ocd)
AMAU: DSM26151_19720(ocd)
ARX: ARZXY2_3448(ocd)
CCYC: SCMU_08240
XCE: Xcel_3303
IDO: I598_2651(rapL_2)
DSS: GCM25873_17060(ocd1)
BSD: BLASA_2548(arcB)
AYM: YM304_01710(ocd)
TDE: TDE_2754(arcB)
 » show all
Reference
  Authors
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE
  Title
Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.
  Journal
Biochemistry 43:13883-91 (2004)
DOI:10.1021/bi048207i
  Sequence
[ppu:PP_3533]
LinkDB

KEGG   ENZYME: 4.3.1.12
Entry
EC 4.3.1.12                 Enzyme                                 
Name
ornithine cyclodeaminase;
ornithine cyclase;
ornithine cyclase (deaminating);
L-ornithine ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
Reaction(IUBMB)
L-ornithine = L-proline + NH3 [RN:R00671]
Reaction(KEGG)
R00671
Substrate
L-ornithine [CPD:C00077]
Product
L-proline [CPD:C00148];
NH3 [CPD:C00014]
Comment
Requires NAD+. The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2].
History
EC 4.3.1.12 created 1976
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01750  ornithine cyclodeaminase
Genes
KPASLUW96_28450
SFJSAMEA4384070_0399
RCBO1V66_04900
EBIEbC_pEb10200380
RPNENCTC8284_02732
RHAEIHV77_05160
LLZLYB30171_01152(ocd)
RGLCS053_10430
XBAC7S18_00305
VNAPN96_18395
VEJVEJY3_17956
PCQPcP3B5_20880(rapL_2)
PMUIG4G71_13415
PNTG5B91_19195
PPUPP_3533
PPFPput_2240
PPGPputGB1_1891 PputGB1_2392
PPWPputW619_1731
PPTPPS_2421
PPBPPUBIRD1_2260
PPIYSA_00067
PPXT1E_0019(arcB)
PPUHB479_09255
PPUTL483_18510
PPUNPP4_23000
PPUDDW66_2681
PMONX969_07215
PMOTX970_07190
PPJRK21_03164
PMOLCLJ08_22330
PALDLU682_012350
PIXRIN61_08375 RIN61_20690
PMOSO165_013995
PFLPFL_3641(arcB)
PPRCPFLCHA0_c36820(arcB1)
PPROPPC_3781
PZAHU749_015780
PFNHZ99_06350
PFSPFLU_3970
PFCPflA506_3344(arcB)
PFBVO64_1052
PTVAA957_04000
PVRPverR02_20305
PAZOAYR47_17555
POIBOP93_08860
PMABU0037_19840
PBREQDY63_12565
PFWPF1751_v1c34300(arcB)
PFFPFLUOLIPICF718770
PFXA7318_16940
PENPSEEN1859(arcB)
PBAPSEBR_a2902
PSVPVLB_08190
PSKU771_21045
PALKPSAKL28_35790
PSECCCOS191_1758(arcB2)
PSOSPOS17_3783
PANRA7J50_3626
PSILPMA3_14245
PYMAK972_1815
PPSHG5J76_16275
PVKEPZ47_14800
PDWBV82_1074
PZEHU754_020320
PVWHU752_015660
PTRTHU722_0011025
PXAKSS93_12240
PSAMHU731_005150
PTZHU718_020500
PQIKH389_18225
PSHHHU773_017095
PXNHU772_008750
PASGKSS96_18625
PFAKKSS94_09120
PMUYKSS95_18470
PMAMKSS90_09155
PORYEJA05_09920
PTKEXN22_10180
PWYHU734_017165
PGFJ0G10_20320
PPEGKUA23_19610
PSIHLOY51_09720
PKMPZ739_15565
PNBNK667_12740
PTAIICN73_18295
PKKQQ992_11585
PKJQ1W70_21530
PHYGJTY93_16465
PPAELDL65_00580
PSJYAA098_12095 AA098_17940
PSNCC0058_21890
PFOUOZ911_15825
PKVQYQ93_18530
PSKPKU43P_36400(arcB_2)
PDEUQEP73_20805
PDENF1C79_11080
PCRPcryo_1795
PSOPSYCG_09555
PALIA3K91_2015
PSPGAK823_10580
PSYGAK825_10835
PSYPE5677_03335
SINVK8B83_11655
SHEAGUY17_09675
PHAPSHAb0543
PTNPTRA_b0777(ocd)
PPHEPP2015_2157
PBWD172_020060
PEAPESP_b0847(ocd)
PNGPNIG_b0727(ocd)
PAGAPAGA_b0945(ocd)
PCARPC2016_3194
PDVFFU37_17275
PSMMPspMM1_37860(ocd)
PXSIEJ103_16570
GAGGlaag_2847
PMESFX988_01147
PSYPCNPT3_02815
MVSMVIS_1158(arcB)
MYAMORIYA_4287(ocd)
MMAAFR932_11860
MOQHWV03_16265
KIMG3T16_01960
CBUCBU_1727(arcB)
CBSCOXBURSA331_A1919(arcB)
CBDCBUD_0275(arcB)
CBGCbuG_0108(arcB)
CBCCbuK_0280(arcB)
CEYCleRT_01960(arcB)
MAHMEALZ_0771(arcB)
FTWFTW_0394
FTLFTL_0578
FTAFTA_0612
FTSF92_03155
FTCDA46_105
FTVCH67_891
FTZCH68_625
FTNFTN_1444
FTXAW25_557
FTDAS84_1058
FTYCH70_486
FCFFNFX1_1481
FCNFN3523_1510
FHIFSC454_07450
FPHFphi_1230
FPTBZ13_774
FPIBF30_1477
FPMLA56_960
FPXKU46_82
FPZLA55_1680
FPJLA02_848
FRTF7308_0826
FNAOOM_0787
FNLM973_08425
FRFLO80_08420
FHACDV26_09240
FRXF7310_02730
FRMBBG19_0336
FRCKX01_1779
FADCDH04_07565
FMIF0R74_06155
FOOCGC45_01670
FNNFSC774_03675
FSRKQR59_07540
FRLFIP56_02635
FGUSD28_05725
AFRIE3E15_03025
AIIE4K63_03275
CYSNYP54_06905
RHHE0Z06_02870
GAIIMCC3135_33495(rapL)
ADIB5T_03949(arcB)
AXEP40_19150
ZDFAN401_05650
SDFACG33_06465
NBACUN60_08955
MAERDAI18_14905
RSORSp0483
RSEF504_3884
RPUCDC45_20035
RNCGO999_24320
RSLRPSI07_mp0417(arcB)
RSNRSPO_m00318(arcB)
RSMCMR15_mp10460(arcB)
RSYRSUY_37340(rapL_3)
RSGJK151_13975
RPJN234_03465
REHH16_A0689(h16_A0689)
CNCCNE_1c06810(arcB1)
CUHBJN34_03865
REUReut_A2671
RMERmet_0586(arcB)
CTIRALTA_A0646
CBWRR42_m0815 RR42_s1855
CGDCR3_2039
CPAUEHF44_02455 EHF44_14210
COXE0W60_13930
CCAMM5D45_03150
CCAXKZ686_14975
CUKKB879_03660
CNANA2G96_04510
CUPRIC580_10680
BOKDM82_5356
BOCBG90_5252
BSAVWS86_29670
BURBcep18194_B2542 Bcep18194_B2946
BCMBcenmc03_3943
BCHBcen2424_3577
BCJBCAM0604
BCENDM39_4558
BCEOI35_4500
BAMBamb_5311
BACBamMC406_3492
BCTGEM_5158
BCEDDM42_4486
BCEPAPZ15_21430
BPYRABD05_18790
BCONNL30_22780
BUBBW23_4328
BDFWI26_16910
BTEIWS51_01570
BSEMWJ12_23010
BPSLWS57_10850
BMECWJ16_22040
BSTGWT74_21255 WT74_22065
BSTLBBJ41_30645
BANNJFN94_20560
BARINLX30_19755
BAENL3V59_30470 L3V59_32700
BGDbgla_2g28110
BGOBM43_2894 BM43_4121 BM43_6554
BGPBGL_1c14730(arcB)
BPLAbpln_1g14430
BURKDM992_28605
BPXBUPH_04873
BUZAYM40_15810
PHSC2L64_35540
PTERC2L65_31300
PCAFDSC91_000487 DSC91_007361
PMEGFNZ07_03115 FNZ07_12515
PPAIE1956_20935
PTXABW99_12315
PNRAT302_25935
PLGNCTC10937_03502
HYFDTO96_101630
LMIRNCTC12852_01501
CABASBC2_69380(ocd_2)
LIMNHKT17_02235
TVLFAZ95_22360 FAZ95_30835
BPTBpet0748
BAVBAV0458(arcB)
BHZACR54_00645(rapL_1)
BTRMSAMEA390648701743(arcB)
BBROBAU06_08925
BPDZBBN53_18480
BOHAKI39_08735
BOJCBF45_07835
BGVCAL12_09350
AXYAXYL_00273(arcB)
AXONH44784_019261
AXNAX27061_0270
AXXERS451415_00270
ADTAPT56_01560
AISBUW96_27095
ASWCVS48_04540
ACHRC2U31_27590
ACHBDVB37_01295
ADYHLG70_20380
APESFOC84_11495
AAEGRA224_01310
ASELRAS12_20240
TEQTEQUI_1395
TEAKUI_0789(arcB)
TEGKUK_0627(arcB)
TASTASI_0895
TATKUM_0109(arcB)
AKATKWG_25100
AMIMMIM_c40550(arcB)
AALNQ3V95_01590
CDNBN940_08081
BPSIIX83_00315
PIGEGT29_14180
PACRFXN63_07375
KGYEHF36_08020
PARKLSG25_08505
RFRRfer_3883
RSBRS694_18800
RACRA876_17415
RHYRD110_02890
RHGEXZ61_03520
RHOAHZ993_16670 HZ993_20070
RMKRAN89_04340
RLHMIZ03_4023
POLBpro_4602
PNAPnap_3771
POSDT070_08180
POOF7R28_01240
PVACHC248_00245(ocd_1)
AJSAjs_0613
ACKC380_02505
ACRABSY15_1884
ACIDCBP33_11605 CBP33_16305
ACIPCBP36_16755
ACINCBP34_17095
ACISCBP35_02165
ACIOEAG14_03255
ARADKI609_02530
ATEMPQV96_15435
ACIQACDW_39420
ACIVEXV95_19540
AAVAave_0121
AAAAcav_0154
AMONH9L24_17580
DACDaci_0682
DELDelCs14_5849
DTSBI380_21320
DHKBO996_03475
DLAI6G47_21255
VAPVapar_4693
VPEVarpa_5329
VPDVAPA_1c48470(arcB)
VBOCKY39_29200
VAMC4F17_22595
VAZH7F35_07945
VAVIG196_27125
CTTCtCNB1_4177
CTESO987_24910
CSERCCO03_01685
CAQTKAQ61_08015
CODOLAD35_09240
CTEZCT3_15090(ocd1)
AANTHUK68_20870
CRJQMY55_20530
CENPM9799_18395
ADNAlide_0698
ADKAlide2_0653
OTDJ1M35_08330
LIML103DPR2_01265(rapL)
LIHL63ED372_00198(rapL)
HYRBSY239_28
HYLLPB072_04060
HYCE5678_11090
HPSEHPF_05975(rapL)
HYNF9K07_23435
HTNKI616_20770
DPYBA022_11910
DIHG7047_12575
DAERH9K75_21635
DRGH9K76_12660
DLSP4826_16010
DIJHND92_04300
DIADtpsy_0592
SIMPC6571_10535
SAQAOMP39_14285
RDPRD2015_3905
ROIN4261_05945
KIAG8A07_22070
PKTAT984_02610
PAQAK9V56_006065
PAISPFX98_24540
SNNEWH46_17780
SMIOCATMQ487_32490(ocd_1) CATMQ487_40770(ocd_2)
IDCLRM40_16240
LCHLcho_0279
RGUA4W93_05310
HSEHsero_0061
HSZACP92_00300
HHTF506_14345
HEEhmeg3_14350
HHFE2K99_00310
UPVEJN92_13860
UPIEJG51_016300
UNDUNDKW_0988(arcB)
UNYUNDYM_0976(arcB)
UCYRF679_17050
NOKFAY22_04195
AONDEH84_05115
TTWLCC91_00400
NCOAAW31_16860
ARESIWH25_08610
APETToN1_36090
AZAAZKH_3290(ocd-2)
AZIAzCIB_3179
AZDCDA09_05625
TMZTmz1t_0586
AZQG3580_03085
MLOmll6776
MLNA9174_13975
MCIMesci_2494 Mesci_5621
MCICA4R28_29655
MOPMesop_3028 Mesop_6204
MAMMesau_02624 Mesau_02786 Mesau_05673
MAMOA6B35_16735
MESWA9K65_013045 A9K65_030505
MESMEJ066_20340
MESPC1M53_04775 C1M53_19735
MHUAMCHK_0400
MJREB229_14090
MERDEB233_27110
MESRFGU64_20125
MMEILRP31_24340
MESJMJ8_63530
MESILGH82_16000
NIYFQ775_13315
NKIKW403_04495
NRHT8J41_09880
MESOBSQ44_22085
MESMeso_3962
AAKAA2016_0895
AMISAmn_53340
PHTBLM14_26880 BLM14_28535
ORMHTY61_11105
KMNHW532_09415
SMESM_b21494(ocd)
SMKSinme_4410
SMQSinmeB_4904
SMXSM11_pD0294(ocd)
SMIBN406_05372(arcB)
SMEGC770_GR4pD0291
SMELSM2011_b21494(ocd)
SMERDU99_26935
RHINGR_b18880(ocd1)
SFHSFHH103_05325(ocd1)
SFDUSDA257_c14360(arcB1)
SIXBSY16_5739
SAMESAMCFNEI73_pC1311(arcB)
SINOSS05631_b54920
ESJSJ05684_b45390
EAKEKH55_5492
SKMPZL22_000539
EADOV14_a0459(ocd1)
EAHFA04_22405 FA04_28080
ECAAJ3R84_25515
ENPJVX98_01715
ATUAtu6016(ocd)
ATAAWN88_05785
AGRAGROH133_12682
ATFAch5_37900(ocd) Ach5_51550
AGCBSY240_2216
AGTEYD00_19340
ALFCFBP5473_20470 CFBP5473_23915
ARUIG6M88_16135
AVQHRR99_18325
AVVRvVAT039_12550
AVFRvVAR031_32460 RvVAR031_pl05760(arcB)
ASALCFBP5507_18915 CFBP5507_27340
RIRBN877_II1136(arcB)
RPUSCFBP5875_19550
ACUCKZ699_20390
ALEGCFBP4996_21170 CFBP4996_25895(ocd) CFBP4996_28650(ocd)
AGRCGSF67_19235
AVIAvi_5979(ocd)
RLERL3095(arcB1)
RTRRTCIAT899_PC06950
RHLLPU83_pLPU83c0744(arcB)
RGARGR602_PB00420
RHRCKA34_23565
RGRFZ934_23230
ROYG3A56_21215 G3A56_22235
RRGJ3P73_15845
RLSHB780_11865
RROSD4A92_09790
RTUPR017_22250
ARAArad_10025(ocdch2) Arad_14151
AROB0909_17715 B0909_19190
RBWRLCC275e_13395
RIFU5G49_002653
RHIBI8E17_20550
NGLRG1141_PA09880
NGGRG540_PA08710
NEOCYG48_17590
NENNCHU2750_47100(ocd) NCHU2750_55520(ocd)
NPMQEO92_19045
RHTNT26_3751(arcB)
RFVRFYW14_03635
SHZshn_29375
SZOK8M09_20750(ocd)
SOJK6301_17230
SSUMQ9314_22660
ABAWD5400_18020
PDESFE840_018490
HOEIMCC20628_03341
ASITN7E02_03270
KAIK32_10430
BMEBMEII0397
BMELDK63_2841
BMIBMEA_B0880
BMZBM28_B0863
BMGBM590_B0862
BMWBMNI_II0836
BMEEDK62_2556
BMFBAB2_0338
BMBBruAb2_0334(arcB)
BMCBAbS19_II03200
BAABAA13334_II00772
BABODK55_2329
BABRDO74_2749
BABTDK49_2903
BABBDK48_2362
BABUDK53_2339
BABSDK51_2918
BABCDO78_2721
BMSBRA0899(arcB)
BSIBS1330_II0891(arcB)
BSFBSS2_II0851(arcB)
BSUIBSSP1_II0844
BSUPBSPT1_II0841
BSUVBSPT2_II0842
BSUCBSSP2_II0853
BMTBSUIS_B0892
BSZDK67_2852
BSVBSVBI22_B0890(arcB)
BSWIY71_15480
BSGIY72_15430
BOVBOV_A0842(arcB)
BCSBCAN_B0918(arcB)
BSKBCA52141_II1767
BOLBCOUA_II0899(arcB)
BCARDK60_2589
BCASDA85_14770
BMRBMI_II893(arcB)
BPPBPI_II955(arcB)
BPVDK65_2752
BCETV910_200393(arcB)
BCEEV568_200442(arcB)
BVLBF3285c2_0422(arcB)
BRUBFS01_12015
BRJBKD03_02080
OINIAR37_12075
BIOBR141012304_20120(arcB)
OANOant_1471
OAHDR92_1038
OPSA8A54_07600 A8A54_10655
BPSNNIK97_05785
BRUCLJ361_18910
OCRHGK82_08680
OCLGTN27_08990
OCCKMS41_07985 KMS41_18620
OCHCES85_1840 CES85_5141
PSCQKHQ08_08135
PSXFLDL70_05865
BOPAXW83_18090
BOSBSY19_2010
BOFFQV39_15965
BOWNWE53_23065
BOSERMR04_05775
STARG3545_23110
LNEFZC33_09155
APRAG3A50_10955
MEAMex_1p3003(arcB)
MDIMETDI3569(arcB)
MEXMext_2802
MCHMchl_3030
MPOMpop_2926
MZAB2G69_21565
METM446_1826
MNOMnod_1216
METAY590_13520
MAQUMaq22A_c19655
MEEDA075_05460
METDC0214_15670
MTEADK419_24160
MINDmvi_29560
MECLCLZ_12815
MIVC4E04_14940
MICOGDR74_05805
MLDU0023_31290
BBARRHAL1_02560(ocd)
DEAFPZ08_06065
DSALK1X15_06555
MMYRMXMO3_03094
MHARL1P08_15305
MSCBN69_2878
MROSEHO51_02220
MHEYH2LOC_008905
MPARF7D14_04555
MIWASS37A_35350
MESZLNB28_05470
PLEOOHA_1_00570(rapL)
MEYTM49_09640
MLUTJET14_20795
AUZSa4125_08580
JAVOXU80_27360
THDBHV28_07820(arcb3)
NOHG5V57_20355
PSFPSE_0777(arcB) PSE_2943(arcB)
PPHRAPZ00_22330
LAPACP90_00665
LABRCHH27_19720
LABPFJ695_03920
LABTFIU93_05740(rapL2)
LAGGB0E33_12165
RPOPK1718_01435
PSTGE8M01_24025
SILSPO2121(arcB)
SITTM1040_1163
RUAD1823_07010
RUTFIU92_06215(rapL1)
RCONK3740_07095
RUYNOR97_06180
RDERD1_1415(arcB)
RLIRLO149_c033720(arcB)
RPONG3256_09570
RFUROLI_022290(ocd)
DSHDshi_2310
PGAPGA1_c16390(arcB)
PGLPGA2_c16220(arcB)
PGDGal_01704
PHPPhaeoP97_01647(arcB)
PPICPhaeoP14_01541(arcB)
PHQD1820_04170
OATOAN307_c23960(arcB2)
OAROA238_c21340(arcB)
OTMOSB_15220(rapL_3)
OCTFTO60_07375
LMDMETH_08475
LEJETW24_09785
LAQUR2C4_08710
LEVETW23_09640
LCAEK3721_08500
CIDP73_4323
CMARIMCC12053_1020
CEHCEW89_03540
CBAKDA792_07665
MALGMALG_01627
YPACCEW88_14105
YANAYJ57_16315
SUAMBOO69_09400
SULZC1J03_13170
SULIC1J05_09240
SULDB5M07_10495
SPOTG6548_09160 G6548_16485
SMEDJNX03_03620
SINLDSM14862_01269(ocd)
SFAVPL335_06160
SUALKDD17_05915
SDUBR1T39_04630
SULBIV89_000172 IV89_001894
SPSESULPSESMR1_01739(arcB)
TOMBWR18_05970
RMMROSMUCSMR3_04003
ROKRAK1035_2839
RIDRIdsm_02486
ROMEI983_07450 EI983_15425
ROHFIU89_08840(rapL3)
RPELN7U68_03625
AHTANTHELSMS3_04135
THAACFI11_10535
ROTFIV09_11025(rapL2)
TGLHFZ77_13085
HATRC74_17170
LSALKBK07_16610
LALGLentiSH36_01386(arcB_2)
TRYQF118_13850
MARUFIU81_06900(rapL2)
RBLB6K69_11065
FYTQF092_04900
PDEPden_4637
PAMIJCM7686_pAMI5p044
PYEA6J80_16535
PZHCX676_03500
PAROCUV01_00650
PARUCYR75_05535 CYR75_15485
PAMNpAMV3p0337(arcB)
PARREOJ32_15535
PAAKFIU66_14430
PMAUCP157_00500(ocd)
PSEWJHW44_01195 JHW44_15845
PFISJHX87_08060
PAEXJHW48_03065
PALSPAF20_17135
PTPRCA23_c24410(arcB)
RMBK529_007560
TSCOR1T40_06060
DONBSK21_06280
RBZB9057_07230
THWBMG03_14400
TECAKL02_013750
LVSLOKVESSMR4R_01472(arcB)
YPHYAABB29_13030
YRHAABB31_01240 AABB31_14095
GFUKM031_16125
TAWEI545_01100
SEDIEBB79_12005
PPSOQPJ95_18060
HMLHmaOT1_18180
BOOE2K80_03460
PSEBEOK75_13900
LITFPZ52_18485
PAEDG5B38_01525
PAMOBAR1_08715
PSHQF3W81_11135
PPAFI8N54_12890
CACTHZ995_15425
THASC6Y53_00125
HDHG5B40_17820
CMAGCBW24_15765
GCEKYE46_16460
GYJAADW23_08950
NSMJO391_06445
ACROK3J57_15615
AALKLGT41_0000305
AMYLQBD29_15305
AMAQGO499_10095
RBGBG454_17045
LVRT8T21_19325
SINRO5O51_00225 O5O51_05555
RCPRCAP_rcc02113(arcB1)
NOVTQ38_023115
NDRHT578_10860
SMAGAN936_15455
SMAZLH19_02825
SWISwit_1052
SPHDHY78_21245
SPHITS85_10390
SPANAWL63_10540
SPHCCVN68_20360
SSUAFPZ54_09335
SCABLZK98_07255
SPYGYGS_C2P1357
GOYGLS_c16230(arcB)
GALA0U94_03395 A0U94_12435
GSPIGS75_08750
AMVACMV_19460(arcB)
RGIRGI145_18290
ROSCTJ15_18365
RMUCFOB66_20160
AZLAZL_b04900(ocd)
ALIAZOLI_p20520(ocd)
ATIAL072_26780
AZMDM194_19800
AZZDEW08_26475
AZSE6C72_23670
HJOAY555_11280
TMOTMO_a0011
ECOGFIV45_03025 FIV45_07905
PAQIKW060_12680
SNEANBZ79_02770
ALKALEK_1697(arcB)
ALPLPB137_02235
PARHI5S86_09520
CBLCLK_0333
CLDCLSPO_c08830(arcB1)
CCAAKQH81_04965
PBIFKXZ80_08170
CARcauri_1343(arcB)
CRDCRES_0238(arcB)
CCJUL81_05640(arcB)
CGVCGLAU_07290(rapL)
CKFI6I12_07130
CPRPI6I69_10625
CLIZG7Y31_05460
CTUBI6I74_10695
CLUJIAU68_06775
CORYFQV43_03385
CMFGWO64_006590
CUWLH390_10545
CACCCACC_05965(rapL)
CJHCJEDD_07415(rapL)
CPSPL9H27_04950
CMASCMASS_04995(rapL)
CCOYCCOY_07320(rapL)
CCOUCCONF_05655(rapL)
CIKH0194_06380
MIXAB663_000786
MIHBJP65_11420
MRNK8F61_08910
MSUWGCM10025863_17010(ocd)
MESTPTQ19_03740
MHOTPU630_15795
MGABKV396_05340
MBETN8K70_14330
MCHNHCR76_17195
AMAUDSM26151_19720(ocd)
AMAVGCM10025877_24060
SALAESZ53_13470
PLAPEAO79_04080
PFLUBWO91_00320
AGROJSQ78_10415
GLNF1C58_09475
ARHAHiyo8_39970
ARXARZXY2_3448(ocd)
ARZAUT26_02050
PSEYGU243_18780
POKSMD14_17730
KPLKPaMU14_01900
RMURMDY18_00780
RDNHMPREF0733_10802
RAJRA11412_0629
RTERIDM49_09350
RAMAIDM48_00425
CCYCSCMU_08240
BFABfae_06630
BRXBH708_17200
BRVCFK39_11375 CFK39_11395
BGGCFK41_13565
BRZCFK38_16100 CFK38_16135
BSAUDWV08_00690
BRRC1N80_00060
BKIM4486_17580
BRHANLU66_17175
BHHBra3105_14300
BHQBRM3_05075
HMMR3I40_10850
XCEXcel_3303
XYLET495_12580
XYAET471_04835
IVAIsova_2937
IDOI598_2651(rapL_2)
PSEKGCM125_11970
JCRO9K63_14610
DEMLGT36_008940
DSSGCM25873_17060(ocd1)
DCPRN607_02665
NAROCFH99_12085
AEBC6I20_14005
ASEZH9L21_10860
ADBNP095_11075
MUZH4N58_03095
BSDBLASA_2548(arcB)
MOMKUM42_12925
TBERQPC17_00810
ARDAXF14_08480
AHWNCTC11636_00832
ACAPMANAM107_02320
AUOR3I39_10340
FSLEJO69_00320
FLHEJ997_01405
AYMYM304_01710(ocd)
SOAG3M56_005800
TDETDE_2754(arcB)
TPKJO40_05945
 » show all
Reference
1  [PMID:4399881]
  Authors
Costilow RN, Laycock L.
  Title
Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions.
  Journal
J Biol Chem 246:6655-60 (1971)
Reference
2  [PMID:4373469]
  Authors
Muth WL, Costilow RN.
  Title
Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme.
  Journal
J Biol Chem 249:7457-62 (1974)
Reference
3  [PMID:10468639]
  Authors
Espineda CE, Linford AS, Devine D, Brusslan JA.
  Title
The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana.
  Journal
Proc Natl Acad Sci U S A 96:10507-11 (1999)
DOI:10.1073/pnas.96.18.10507
Reference
4  [PMID:15518536]
  Authors
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE
  Title
Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.
  Journal
Biochemistry 43:13883-91 (2004)
DOI:10.1021/bi048207i
  Sequence
[ppu:PP_3533]
Reference
5  [PMID:15103146]
  Authors
Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE.
  Title
Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida.
  Journal
Acta Crystallogr D Biol Crystallogr 60:941-4 (2004)
DOI:10.1107/S0907444904005256
  Sequence
[ppu:PP_3533]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.12
IUBMB Enzyme Nomenclature: 4.3.1.12
ExPASy - ENZYME nomenclature database: 4.3.1.12
BRENDA, the Enzyme Database: 4.3.1.12
CAS: 9054-76-6
LinkDB

KEGG   REACTION: R00671
Entry
R00671                      Reaction                               
Name
L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
Definition
L-Ornithine <=> L-Proline + Ammonia
Equation
Reaction class
RC00354  C00077_C00148
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.12
     R00671  L-Ornithine <=> L-Proline + Ammonia
Orthology
K01750  ornithine cyclodeaminase [EC:4.3.1.12]
Other DBs
RHEA: 24371
LinkDB

DBGET integrated database retrieval system