KEGG ORTHOLOGY: K01828

ORTHOLOGY: K01828

Entry

K01828            Tight     KO

Symbol

NISO

Name

neopinone isomerase [EC:5.3.3.24]

Pathway

map00950

Isoquinoline alkaloid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R05125

neopinone Delta8-Delta7-isomerase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K01828  NISO; neopinone isomerase
Enzymes [BR:ko01000]
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.24  neopinone isomerase
     K01828  NISO; neopinone isomerase

Genes

PSOM:

113320582 113323967 113325420

Reference

PMID:30886433

Authors

Dastmalchi M, Chen X, Hagel JM, Chang L, Chen R, Ramasamy S, Yeaman S, Facchini PJ.

Title

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy.

Journal

Nat Chem Biol 15:384-390 (2019)
DOI:10.1038/s41589-019-0247-0

Sequence

[psom:113325420 113320582]

LinkDB

ENZYME: 5.3.3.24

Entry

EC 5.3.3.24                 Enzyme

Name

neopinone isomerase;
NISO (gene name)

Class

Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds

Sysname

neopinone Delta8-Delta7-isomerase

Reaction(IUBMB)

neopinone = codeinone [RN:R05125]

Reaction(KEGG)

R05125

Substrate

neopinone [CPD:C06172]

Product

codeinone [CPD:C06171]

Comment

The enzyme, characterized from the opium poppy (Papaver somniferum), participates in the biosynthesis of morphine. It also catalyses the isomerization of neomorphinone and morphinone.

History

EC 5.3.3.24 created 2022

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K01828

neopinone isomerase

Genes

PSOM:

113320582 113323967 113325420

Reference

1 [PMID:30886433]

Authors

Dastmalchi M, Chen X, Hagel JM, Chang L, Chen R, Ramasamy S, Yeaman S, Facchini PJ.

Title

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy.

Journal

Nat Chem Biol 15:384-390 (2019)
DOI:10.1038/s41589-019-0247-0

Sequence

[psom:113325420 113320582]

Other DBs

ExplorEnz - The Enzyme Database:

5.3.3.24

IUBMB Enzyme Nomenclature:

5.3.3.24

ExPASy - ENZYME nomenclature database:

5.3.3.24

BRENDA, the Enzyme Database:

5.3.3.24

LinkDB

REACTION: R05125

Entry

R05125                      Reaction

Name

neopinone Delta8-Delta7-isomerase

Definition

Codeinone <=> Neopinone

Equation

C06171 <=> C06172

Reaction class

RC01272

C06171_C06172

Enzyme

5.3.3.24

Pathway

rn00950

Isoquinoline alkaloid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.24
     R05125  Codeinone <=> Neopinone

Orthology

K01828

neopinone isomerase [EC:5.3.3.24]

Other DBs

RHEA:

75130

LinkDB

DBGET integrated database retrieval system