KEGG   ORTHOLOGY: K01852
Entry
K01852                      KO                                     
Symbol
LSS, ERG7
Name
lanosterol synthase [EC:5.4.99.7]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Disease
H00786  Hypotrichosis
H01202  Cataract
H02303  Alopecia-mental retardation syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K01852  LSS, ERG7; lanosterol synthase
Enzymes [BR:ko01000]
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.99  Transferring other groups
    5.4.99.7  lanosterol synthase
     K01852  LSS, ERG7; lanosterol synthase
Other DBs
RN: R03199
COG: COG1657
GO: 0000250
Genes
HSA: 4047(LSS)
PTR: 474058(LSS)
PPS: 100974593(LSS)
GGO: 101124004(LSS)
PON: 100432375(LSS)
NLE: 100592843(LSS)
MCC: 709227(LSS)
MCF: 102137329(LSS)
MTHB: 126950599
CSAB: 103220328(LSS)
CATY: 105575561(LSS)
PANU: 101006026(LSS)
TGE: 112620282(LSS)
RRO: 104667600(LSS)
RBB: 108512153
TFN: 117095879(LSS)
PTEH: 111527943(LSS)
CJC: 100409467(LSS)
SBQ: 101032145(LSS)
CSYR: 103257838(LSS)
MMUR: 105879670(LSS)
LCAT: 123630831(LSS)
OGA: 100948133(LSS)
MMU: 16987(Lss)
MCAL: 110302909(Lss)
MPAH: 110326638(Lss)
RNO: 81681(Lss)
MCOC: 116075533(Lss)
MUN: 110546351(Lss)
CGE: 100753498(Lss)
MAUA: 101839557(Lss)
PLEU: 114696515(Lss)
MORG: 121435496(Lss)
MFOT: 126501852
AAMP: 119822439(Lss)
NGI: 103739961(Lss)
HGL: 101713900(Lss)
CPOC: 100728014(Lss)
CCAN: 109695890(Lss)
DORD: 105998238(Lss)
DSP: 122121146(Lss)
NCAR: 124992709
OCU: 100359315(LSS)
OPI: 101531461(LSS)
TUP: 102473663(LSS)
CFA: 491611(LSS)
CLUD: 112669241(LSS)
VVP: 112909549(LSS)
VLG: 121479453(LSS)
AML: 100482594(LSS)
UMR: 103680679(LSS)
UAH: 113258959(LSS)
UAR: 123779130(LSS)
ELK: 111155646
LLV: 125093088
MPUF: 101694228(LSS)
ORO: 101375055(LSS)
EJU: 114201843(LSS)
ZCA: 113917146(LSS)
MLX: 118026933(LSS)
NSU: 110571098(LSS)
FCA: 101080651(LSS)
PYU: 121035833(LSS)
PBG: 122491068(LSS)
LRUF: 124526737
PTG: 102962591(LSS)
PPAD: 109258102(LSS)
AJU: 106987528(LSS)
HHV: 120223916(LSS)
BTA: 615906(LSS)
BOM: 102277039(LSS)
BIU: 109561307(LSS)
BBUB: 102395472(LSS)
CHX: 102175810(LSS)
OAS: 101106995(LSS)
ODA: 120881088(LSS)
CCAD: 122445445(LSS)
SSC: 100625138(LSS)
CFR: 102516637(LSS)
CBAI: 105077990(LSS)
CDK: 105090588(LSS)
VPC: 102528619(LSS)
BACU: 103005228(LSS)
LVE: 103077252(LSS)
OOR: 101289294(LSS)
DLE: 111186240(LSS)
PSIU: 116753012(LSS)
ECB: 100055292(LSS)
EPZ: 103558417(LSS)
EAI: 106842988(LSS)
MYB: 102244769(LSS)
MYD: 102755441(LSS)
MMYO: 118676077(LSS)
MLF: 102417671(LSS)
MNA: 107536230(LSS)
PKL: 118724659(LSS)
DRO: 112306546(LSS)
SHON: 119000237(LSS)
AJM: 119058762(LSS)
PDIC: 114490463(LSS)
PHAS: 123828012(LSS)
MMF: 118617180(LSS)
RFQ: 117035290
PALE: 102897618(LSS)
PGIG: 120616399(LSS)
PVP: 105308829(LSS)
RAY: 107510225(LSS)
MJV: 108409563(LSS)
TOD: 119257142(LSS)
SARA: 101536901(LSS)
LAV: 100662429(LSS)
TMU: 101341011
DNM: 101414303(LSS)
GAS: 123247639(LSS)
SHR: 100933933(LSS)
PCW: 110198829(LSS)
OAA: 100083602(LSS)
GGA: 424037(LSS)
PCOC: 116236010(LSS)
MGP: 100544500(LSS)
CJO: 107316378(LSS)
NMEL: 110399885(LSS)
APLA: 101801199(LSS)
ACYG: 106030113(LSS)
AFUL: 116490643(LSS)
TGU: 100223318(LSS)
LSR: 110471683(LSS)
SCAN: 103814750(LSS)
PMOA: 120511549(LSS)
OTC: 121332050(LSS)
PRUF: 121364442(LSS)
GFR: 102037340(LSS)
FAB: 101809334(LSS)
PHI: 102113695(LSS)
CCAE: 111931893(LSS)
CCW: 104698254(LSS)
CBRC: 103621389(LSS)
ETL: 114070053(LSS)
ZAB: 102064988(LSS)
ACHL: 103803671(LSS)
FPG: 101912237(LSS)
FCH: 102059359(LSS)
CLV: 102092351(LSS)
EGZ: 104133503(LSS)
NNI: 104013643(LSS)
PLET: 104622881(LSS)
PCRI: 104032745(LSS)
PCAO: 104043881(LSS)
ACUN: 113482095(LSS)
TALA: 104368071(LSS)
PADL: 103922915(LSS)
AFOR: 103902144(LSS)
ACHC: 115342554(LSS)
HALD: 104315455(LSS)
CCRI: 104165960(LSS)
CSTI: 104553151(LSS)
EHS: 104515075(LSS)
CMAC: 104481172(LSS)
MUI: 104546177(LSS)
FGA: 104077424(LSS)
GSTE: 104258188(LSS)
LDI: 104351049(LSS)
MNB: 103777685(LSS)
OHA: 104338891(LSS)
NNT: 104409407(LSS)
DPUB: 104296669(LSS)
PGUU: 104464273(LSS)
ACAR: 104525530(LSS)
AVIT: 104280786(LSS)
CVF: 104292074(LSS)
CUCA: 104064562(LSS)
AAM: 106492318(LSS)
AROW: 112975121(LSS)
NPD: 112955597(LSS)
TGT: 104575220(LSS)
DNE: 112978872(LSS)
SCAM: 104146172(LSS)
ASN: 102375533(LSS)
AMJ: 102568061(LSS)
CPOO: 109323021(LSS)
GGN: 109301919(LSS)
CMY: 102946034(LSS)
CABI: 116829071(LSS)
ACS: 100558321(lss)
PVT: 110090934
SUND: 121919889(LSS) 121928990
PMUR: 107296168(LSS)
CTIG: 120297402 120300363(LSS)
VKO: 123024380(LSS)
PMUA: 114582271(LSS) 114598445
ZVI: 118079446 118097047(LSS)
GJA: 107122323(LSS)
STOW: 125434939(LSS)
XLA: 108703025(lss.S)
XTR: 733925(lss)
NPR: 108793617(LSS)
RTEM: 120943921(LSS)
DRE: 795400(lss)
SGH: 107555930(lss)
CCAR: 109088812(lss)
CAUA: 113108388(lss)
PPRM: 120461497(lss)
MAMB: 125270564(lss)
IPU: 108266196(lss)
PHYP: 113526032(lss)
SMEO: 124383367(lss)
TFD: 113654128(lss)
AMEX: 103022113(lss)
EEE: 113567698(lss)
TRU: 101062227(lss)
LCO: 104920782(lss)
CGOB: 115026579(lss)
ELY: 117249962(lss)
EFO: 125900133(lss)
PLEP: 121949264(lss)
SLUC: 116053545
ECRA: 117952976(lss)
ESP: 116698456(lss)
PFLV: 114564414(lss)
GAT: 120834092(lss)
PPUG: 119229081(lss)
MSAM: 119903407(lss) 119903566
CUD: 121522678(lss)
ALAT: 119026489(lss)
MZE: 101485469(lss)
ONL: 100690152
OAU: 116309479(lss)
OLA: 101157258 101157497(lss)
OML: 112155265(lss)
XMA: 102229476(lss)
XCO: 114148334(lss)
XHE: 116723508(lss)
PRET: 103461854(lss)
PFOR: 103138128(lss)
PLAI: 106939999(lss)
PMEI: 106916303(lss)
GAF: 122840377(lss)
CVG: 107086194(lss)
CTUL: 119774029(lss)
GMU: 124870941(lss)
NFU: 107373714(lss)
ALIM: 106529310(lss) 106529311
AOCE: 111582860(lss)
CSEM: 103392388(lss)
POV: 109644787(lss)
SSEN: 122759031(lss)
HHIP: 117755142(lss)
HSP: 118119648(lss)
LCF: 108897198
SDU: 111218455(lss)
SLAL: 111667391(lss)
XGL: 120801101(lss)
HCQ: 109517560(lss)
BPEC: 110167885(lss)
MALB: 109972638(lss)
BSPL: 114846833(lss)
SASA: 106581851(lss)
STRU: 115156153(lss)
OTW: 112225134(lss)
OMY: 110501565(lss)
OGO: 124041837(lss)
ONE: 115137059(lss)
SALP: 111959367(lss)
SNH: 120064445(lss)
CCLU: 121551435(lss)
ELS: 105016172(lss)
SFM: 108924262(lss)
PKI: 111845428(lss)
AANG: 118222420(lss)
LOC: 102696203(lss)
PSPA: 121323023(lss)
ARUT: 117400328(lss)
LCM: 102361349(LSS)
CMK: 103188931(lss)
BFO: 118424025
BBEL: 109486591
SPU: 576764
BGT: 106070452
GAE: 121380915
ATH: AT3G45130(LAS1)
ALY: 9311782
THJ: 104799632
PALZ: 118061782
SCE: YHR072W(ERG7)
SEUB: DI49_2476
ERC: Ecym_8182
KMX: KLMA_30341(ERG7)
NCS: NCAS_0H01640(NCAS0H01640)
NDI: NDAI_0C01970(NDAI0C01970)
TPF: TPHA_0E01120(TPHA0E01120)
TBL: TBLA_0A03120(TBLA0A03120)
TDL: TDEL_0E02760(TDEL0E02760)
KAF: KAFR_0D04670(KAFR0D04670)
KNG: KNAG_0B04580(KNAG0B04580)
PIC: PICST_77382(ERG7)
CAL: CAALFM_C202460WA(ERG7)
CDU: CD36_17130(ERG7)
SLB: AWJ20_3290(ERG7)
BNN: FOA43_004550(ERG7)
BBRX: BRETT_001869(ERG7)
NCR: NCU01119
NTE: NEUTE1DRAFT127722(NEUTE1DRAFT_127722)
MGR: MGG_11702
MAW: MAC_04069
MAJ: MAA_01453
CMT: CCM_09526
MBE: MBM_02694
ANG: ANI_1_1064084(An09g01330) ANI_1_846084(An09g06490)
ALUC: AKAW2_40649S(ERG7_3)
ACHE: ACHE_60781A(ERG7)
APUU: APUU_20800A(ERG7_1) APUU_31278A(ERG7_2) APUU_60585A(ERG7_3)
ABE: ARB_06777
TVE: TRV_05691
PTE: PTT_15458
SPO: SPAC13G7.01c(erg7)
CNE: CND02520
TASA: A1Q1_07921
ABP: AGABI1DRAFT55056(AGABI1DRAFT_55056)
ABV: AGABI2DRAFT206259(AGABI2DRAFT_206259)
MGL: MGL_1532
MRT: MRET_3825
DDI: DDB_G0269226(cas1)
 » show all
Reference
PMID:6027261
  Authors
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ
  Title
A soluble 2,3-oxidosqualene sterol cyclase.
  Journal
J Biol Chem 242:3014-5 (1967)
Reference
PMID:7639730
  Authors
Baker CH, Matsuda SP, Liu DR, Corey EJ
  Title
Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library.
  Journal
Biochem Biophys Res Commun 213:154-60 (1995)
DOI:10.1006/bbrc.1995.2110
  Sequence
[hsa:4047]
Reference
PMID:8134375
  Authors
Corey EJ, Matsuda SP, Bartel B
  Title
Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase.
  Journal
Proc Natl Acad Sci U S A 91:2211-5 (1994)
DOI:10.1073/pnas.91.6.2211
  Sequence
[sce:YHR072W]
Reference
  Authors
Suzuki M, Xiang T, Ohyama K, Seki H, Saito K, Muranaka T, Hayashi H, Katsube Y, Kushiro T, Shibuya M, Ebizuka Y
  Title
Lanosterol synthase in dicotyledonous plants.
  Journal
Plant Cell Physiol 47:565-71 (2006)
DOI:10.1093/pcp/pcj031
  Sequence
[ath:AT3G45130]
LinkDB

KEGG   ENZYME: 5.4.99.7
Entry
EC 5.4.99.7                 Enzyme                                 
Name
lanosterol synthase;
2,3-epoxysqualene lanosterol cyclase;
squalene-2,3-oxide-lanosterol cyclase;
lanosterol 2,3-oxidosqualene cyclase;
squalene 2,3-epoxide:lanosterol cyclase;
2,3-oxidosqualene sterol cyclase;
oxidosqualene cyclase;
2,3-oxidosqualene cyclase;
2,3-oxidosqualene-lanosterol cyclase;
oxidosqualene-lanosterol cyclase;
squalene epoxidase-cyclase;
(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lanosterol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol [RN:R03199]
Reaction(KEGG)
R03199
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
lanosterol [CPD:C01724]
History
EC 5.4.99.7 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 5.4.99.7 rest to EC 1.14.99.7
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01852  lanosterol synthase
Genes
HSA4047(LSS)
PTR474058(LSS)
PPS100974593(LSS)
GGO101124004(LSS)
PON100432375(LSS)
NLE100592843(LSS)
MCC709227(LSS)
MCF102137329(LSS)
MTHB126950599
CSAB103220328(LSS)
CATY105575561(LSS)
PANU101006026(LSS)
TGE112620282(LSS)
RRO104667600(LSS)
RBB108512153
TFN117095879(LSS)
PTEH111527943(LSS)
CJC100409467(LSS)
SBQ101032145(LSS)
CSYR103257838(LSS)
MMUR105879670(LSS)
LCAT123630831(LSS)
OGA100948133(LSS)
MMU16987(Lss)
MCAL110302909(Lss)
MPAH110326638(Lss)
RNO81681(Lss)
MCOC116075533(Lss)
MUN110546351(Lss)
CGE100753498(Lss)
MAUA101839557(Lss)
PLEU114696515(Lss)
MORG121435496(Lss)
MFOT126501852
AAMP119822439(Lss)
NGI103739961(Lss)
HGL101713900(Lss)
CPOC100728014(Lss)
CCAN109695890(Lss)
DORD105998238(Lss)
DSP122121146(Lss)
NCAR124992709
OCU100359315(LSS)
OPI101531461(LSS)
TUP102473663(LSS)
CFA491611(LSS)
CLUD112669241(LSS)
VVP112909549(LSS)
VLG121479453(LSS)
AML100482594(LSS)
UMR103680679(LSS)
UAH113258959(LSS)
UAR123779130(LSS)
ELK111155646
LLV125093088
MPUF101694228(LSS)
ORO101375055(LSS)
EJU114201843(LSS)
ZCA113917146(LSS)
MLX118026933(LSS)
NSU110571098(LSS)
FCA101080651(LSS)
PYU121035833(LSS)
PBG122491068(LSS)
LRUF124526737
PTG102962591(LSS)
PPAD109258102(LSS)
AJU106987528(LSS)
HHV120223916(LSS)
BTA615906(LSS)
BOM102277039(LSS)
BIU109561307(LSS)
BBUB102395472(LSS)
CHX102175810(LSS)
OAS101106995(LSS)
ODA120881088(LSS)
CCAD122445445(LSS)
SSC100625138(LSS)
CFR102516637(LSS)
CBAI105077990(LSS)
CDK105090588(LSS)
VPC102528619(LSS)
BACU103005228(LSS)
LVE103077252(LSS)
OOR101289294(LSS)
DLE111186240(LSS)
PSIU116753012(LSS)
ECB100055292(LSS)
EPZ103558417(LSS)
EAI106842988(LSS)
MYB102244769(LSS)
MYD102755441(LSS)
MMYO118676077(LSS)
MLF102417671(LSS)
MNA107536230(LSS)
PKL118724659(LSS)
DRO112306546(LSS)
SHON119000237(LSS)
AJM119058762(LSS)
PDIC114490463(LSS)
PHAS123828012(LSS)
MMF118617180(LSS)
RFQ117035290
PALE102897618(LSS)
PGIG120616399(LSS)
PVP105308829(LSS)
RAY107510225(LSS)
MJV108409563(LSS)
TOD119257142(LSS)
SARA101536901(LSS)
LAV100662429(LSS)
TMU101341011
DNM101414303(LSS)
GAS123247639(LSS)
SHR100933933(LSS)
PCW110198829(LSS)
OAA100083602(LSS)
GGA424037(LSS)
PCOC116236010(LSS)
MGP100544500(LSS)
CJO107316378(LSS)
NMEL110399885(LSS)
APLA101801199(LSS)
ACYG106030113(LSS)
AFUL116490643(LSS)
TGU100223318(LSS)
LSR110471683(LSS)
SCAN103814750(LSS)
PMOA120511549(LSS)
OTC121332050(LSS)
PRUF121364442(LSS)
GFR102037340(LSS)
FAB101809334(LSS)
PHI102113695(LSS)
CCAE111931893(LSS)
CCW104698254(LSS)
CBRC103621389(LSS)
ETL114070053(LSS)
ZAB102064988(LSS)
ACHL103803671(LSS)
FPG101912237(LSS)
FCH102059359(LSS)
CLV102092351(LSS)
EGZ104133503(LSS)
NNI104013643(LSS)
PLET104622881(LSS)
PCRI104032745(LSS)
PCAO104043881(LSS)
ACUN113482095(LSS)
TALA104368071(LSS)
PADL103922915(LSS)
AFOR103902144(LSS)
ACHC115342554(LSS)
HALD104315455(LSS)
CCRI104165960(LSS)
CSTI104553151(LSS)
EHS104515075(LSS)
CMAC104481172(LSS)
MUI104546177(LSS)
FGA104077424(LSS)
GSTE104258188(LSS)
LDI104351049(LSS)
MNB103777685(LSS)
OHA104338891(LSS)
NNT104409407(LSS)
DPUB104296669(LSS)
PGUU104464273(LSS)
ACAR104525530(LSS)
AVIT104280786(LSS)
CVF104292074(LSS)
CUCA104064562(LSS)
AAM106492318(LSS)
AROW112975121(LSS)
NPD112955597(LSS)
TGT104575220(LSS)
DNE112978872(LSS)
SCAM104146172(LSS)
ASN102375533(LSS)
AMJ102568061(LSS)
CPOO109323021(LSS)
GGN109301919(LSS)
CMY102946034(LSS)
CABI116829071(LSS)
MRV120374232 120374242 120374980
ACS100558321(lss)
PVT110090934
SUND121919889(LSS) 121928990
PMUR107296168(LSS)
CTIG120297402 120300363(LSS)
PGUT117659519 117664346 117671165(LSS)
VKO123024380(LSS)
PMUA114582271(LSS) 114598445
ZVI118079446 118097047(LSS)
GJA107122323(LSS)
STOW125434939(LSS)
XLA108703025(lss.S)
XTR733925(lss)
NPR108793617(LSS)
RTEM120943921(LSS)
BBUF121008548 121008549
BGAR122944874 122945066
DRE795400(lss)
SRX107714200 107741934
SANH107660663 107673746
SGH107555930(lss)
CCAR109088812(lss)
CAUA113108388(lss)
PPRM120461497(lss)
MAMB125270564(lss)
IPU108266196(lss)
PHYP113526032(lss)
SMEO124383367(lss)
TFD113654128(lss)
AMEX103022113(lss)
EEE113567698(lss)
TRU101062227(lss)
TNGGSTEN00029216G001
LCO104920782(lss)
CGOB115026579(lss)
ELY117249962(lss)
EFO125900133(lss)
PLEP121949264(lss)
SLUC116053545
ECRA117952976(lss)
ESP116698456(lss)
PFLV114564414(lss)
GAT120834092(lss)
PPUG119229081(lss)
MSAM119903407(lss) 119903566
CUD121522678(lss)
ALAT119026489(lss)
MZE101485469(lss)
ONL100690152
OAU116309479(lss)
OLA101157258 101157497(lss)
OML112155265(lss)
XMA102229476(lss)
XCO114148334(lss)
XHE116723508(lss)
PRET103461854(lss)
PFOR103138128(lss)
PLAI106939999(lss)
PMEI106916303(lss)
GAF122840377(lss)
CVG107086194(lss)
CTUL119774029(lss)
GMU124870941(lss)
NFU107373714(lss)
KMR108247360 108247361 108247362
ALIM106529310(lss) 106529311
NWH119418993 119418994 119419509 119419797
AOCE111582860(lss)
MCEP125017960 125017961
CSEM103392388(lss)
POV109644787(lss)
SSEN122759031(lss)
HHIP117755142(lss)
HSP118119648(lss)
LCF108897198
SDU111218455(lss)
SLAL111667391(lss)
XGL120801101(lss)
HCQ109517560(lss)
BPEC110167885(lss)
MALB109972638(lss)
BSPL114846833(lss)
SASA106581851(lss)
STRU115156153(lss)
OTW112225134(lss)
OMY110501565(lss)
OGO124041837(lss)
ONE115137059(lss)
SALP111959367(lss)
SNH120064445(lss)
CCLU121551435(lss)
ELS105016172(lss)
SFM108924262(lss)
PKI111845428(lss)
AANG118222420(lss)
LOC102696203(lss)
PSPA121323023(lss)
ARUT117400328(lss)
LCM102361349(LSS)
CMK103188931(lss)
BFO118424025
BBEL109486591
SPU576764
BGT106070452
GAE121380915
HRF124120694 124128846 124141585 124141615
HRJ124253014 124263131
ATHAT3G45130(LAS1)
ALY9311782
EUSEUTSA_v10001913mg
THJ104799632
MNT112090552 112095065
PALZ118061782
PVIR120640014 120645568
SCEYHR072W(ERG7)
SEUBDI49_2476
SPAOSPAR_H01130
AGOAGOS_AGR351W
ERCEcym_8182
KLAKLLA0_B10175g
KMXKLMA_30341(ERG7)
LTHKLTH0H14850g
VPOKpol_339p12
ZROZYRO0D10164g
CGRCAGL0J10824g
NCSNCAS_0H01640(NCAS0H01640)
NDINDAI_0C01970(NDAI0C01970)
TPFTPHA_0E01120(TPHA0E01120)
TBLTBLA_0A03120(TBLA0A03120)
TDLTDEL_0E02760(TDEL0E02760)
TGBHG536_0E02890
KAFKAFR_0D04670(KAFR0D04670)
KNGKNAG_0B04580(KNAG0B04580)
ZMKHG535_0C03300
PPAPAS_chr2-1_0391
DHADEHA2C05764g
PICPICST_77382(ERG7)
PGUPGUG_05319
SPAASPAPADRAFT_55185
LELLELG_00573
CALCAALFM_C202460WA(ERG7)
CTPCTRG_01395
COTCORT_0A05450
CDUCD36_17130(ERG7)
CTENCANTEDRAFT_105173
YLIYALI0F04378g
CLUCLUG_00911
CLUSA9F13_10g01925
CAURCJI97_005090
SLBAWJ20_3290(ERG7)
PKZC5L36_0B03220
BNNFOA43_004550(ERG7)
BBRXBRETT_001869(ERG7)
OPAHPODL_03376
SLUDSCDLUD_004580
NCRNCU01119
NTENEUTE1DRAFT127722(NEUTE1DRAFT_127722)
SMPSMAC_03193
PANPODANSg8579
TTTTHITE_129749
MTMMYCTH_2301508
CTHRCTHT_0027770
MGRMGG_11702
PPEIPpBr36_07763
TMNUCRPA7_3525
FGRFGSG_05950
FPUFPSE_03029
FVRFVEG_04575
FOXFOXG_07651
NHENECHADRAFT_72055
TRETRIREDRAFT_59846
TRRM419DRAFT_136748
MAWMAC_04069
MAJMAA_01453
CMTCCM_09526
PLJVFPFJ_08272
VALVDBG_01893 VDBG_07639
VDAVDAG_01664 VDAG_09360
CFJCFIO01_01052
CLUPCLUP02_07513
CHIGCH63R_03890 CH63R_07103
SAPOSAPIO_CDS8304
ELAUCREL1_4598
PFYPFICI_07703
SSLSS1G_01528
BFUBCIN_02g00670
MBEMBM_02694
PSCOLY89DRAFT_584828
GLZGLAREA_06531
ANIAN8249.2 AN8260.2
AFMAFUA_4G12040 AFUA_5G04080
ACTACLA_001090
NFINFIA_038030 NFIA_104210
AORAO090020000194 AO090102000611 AO090166000068
ANGANI_1_1064084(An09g01330) ANI_1_846084(An09g06490)
AFVAFLA_010467 AFLA_011429 AFLA_012044
ALUCAKAW2_40649S(ERG7_3)
ACHEACHE_60781A(ERG7)
APUUAPUU_20800A(ERG7_1) APUU_31278A(ERG7_2) APUU_60585A(ERG7_3)
PCSPc22g14100
PDPPDIP_53520
TMFPMAA_083410
TRGTRUGW13939_08302
CIMCIMG_02792 CIMG_06646
CPWCPC735_031030 CPC735_036410
UREUREG_03791
PBLPAAG_04196
PBNPADG_07451
ABEARB_06777
TVETRV_05691
AJEHCAG_00613
BGHBDBG_01260
PNOSNOG_11162
PTEPTT_15458
BZECOCCADRAFT_86820
BSCCOCSADRAFT_197124
BORCOCMIDRAFT_8644
AALTCC77DRAFT_728315
PFJMYCFIDRAFT_32198
FFUCLAFUR5_07287
NPAUCRNP2_3498
TMLGSTUM_00011699001
SPOSPAC13G7.01c(erg7)
CNECND02520
CNGCNAG_01129
TASAA1Q1_07921
TVSTRAVEDRAFT_167400
SHSSTEHIDRAFT_57720
HIRHETIRDRAFT_453585
PSQPUNSTDRAFT_106358
ADLAURDEDRAFT_115430
FMEFOMMEDRAFT_100769
GTRGLOTRDRAFT_82165
LBCLACBIDRAFT_185468
CCICC1G_05695
ABPAGABI1DRAFT55056(AGABI1DRAFT_55056)
ABVAGABI2DRAFT206259(AGABI2DRAFT_206259)
PCUBJR316_0008240
MPRMPER_02146 MPER_03149
MOREE1B28_003115 E1B28_007407
CPUTCONPUDRAFT_127073
SLASERLADRAFT_451021
WSEWALSEDRAFT_14803
WICJ056_002076
UMAUMAG_10079
PFPPFL1_02548
MGLMGL_1532
MRTMRET_3825
MSYMMSY001_2440
DDIDDB_G0269226(cas1)
DPPDICPUDRAFT_74059
TBRTb927.7.5230
TBGTbgDal_VII6010
TCR506825.170 508175.70
LMALMJF_06_0650
LIFLINJ_06_0670
LDOLDBPK_060670
LPANLPMP_060620
MEINmethR_P0930
MFBMFUL124B02_14110
 » show all
Reference
1  [PMID:6027261]
  Authors
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ
  Title
A soluble 2,3-oxidosqualene sterol cyclase.
  Journal
J Biol Chem 242:3014-5 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.7
IUBMB Enzyme Nomenclature: 5.4.99.7
ExPASy - ENZYME nomenclature database: 5.4.99.7
BRENDA, the Enzyme Database: 5.4.99.7
CAS: 9032-71-7
LinkDB

KEGG   REACTION: R03199
Entry
R03199                      Reaction                               
Name
(S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming)
Definition
(S)-2,3-Epoxysqualene <=> Lanosterol
Equation
Reaction class
RC00874  C01054_C01724
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Orthology
K01852  lanosterol synthase [EC:5.4.99.7]
Other DBs
RHEA: 14624
LinkDB

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