KEGG   ORTHOLOGY: K01957
Entry
K01957            Tight     KO                                     
Symbol
ddaH
Name
N-3-fumaroyl-(S)-2,3-diaminopropanoate amidotransferase [EC:6.3.5.-]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00904  Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C
Reaction
R12352  N3-fumaroyl-L-2,3-diaminopropanoate:L-glutamine amido-ligase (AMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K01957  ddaH; N-3-fumaroyl-(S)-2,3-diaminopropanoate amidotransferase
Other DBs
COG: COG0367
Genes
SPE: Spro_0346
SPLY: Q5A_016895(asnB_2)
PVA: Pvag_pPag20165(asnB)
PAGC: BEE12_22720
Reference
PMID:19807062
  Authors
Hollenhorst MA, Clardy J, Walsh CT
  Title
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
  Journal
Biochemistry 48:10467-72 (2009)
DOI:10.1021/bi9013165
Reference
PMID:20041689
  Authors
Dawlaty J, Zhang X, Fischbach MA, Clardy J
  Title
Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases.
  Journal
J Nat Prod 73:441-6 (2010)
DOI:10.1021/np900685z
  Sequence
[pagc:BEE12_22720]
LinkDB

KEGG   REACTION: R12352
Entry
R12352                      Reaction                               
Name
N3-fumaroyl-L-2,3-diaminopropanoate:L-glutamine amido-ligase (AMP-forming)
Definition
N3-Fumaroyl-L-2,3-diaminopropanoate + L-Glutamine + ATP + H2O <=> 3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanine + L-Glutamate + AMP + Diphosphate
Equation
C20961 + C00064 + C00002 + C00001 <=> C20966 + C00025 + C00020 + C00013
Comment
proposed pathway
not yet characterized sufficiently
Reaction class
RC00950  C20961_C20966
Enzyme
6.3.5.-
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00904  Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.-
     R12352  N3-Fumaroyl-L-2,3-diaminopropanoate + L-Glutamine + ATP + H2O <=> 3-{[(2E)-4-Amino-4-oxobut-2-enoyl]amino}-L-alanine + L-Glutamate + AMP + Diphosphate
Orthology
K01957  N-3-fumaroyl-(S)-2,3-diaminopropanoate amidotransferase [EC:6.3.5.-]
Reference
1  [PMID:19807062]
  Authors
Hollenhorst MA, Clardy J, Walsh CT
  Title
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
  Journal
Biochemistry 48:10467-72 (2009)
DOI:10.1021/bi9013165
LinkDB

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