KEGG   ORTHOLOGY: K02228
Entry
K02228                      KO                                     
Symbol
cobF
Name
precorrin-6A synthase [EC:2.1.1.152]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00925  Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K02228  cobF; precorrin-6A synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.152  precorrin-6A synthase (deacetylating)
     K02228  cobF; precorrin-6A synthase
Other DBs
RN: R05219
COG: COG2243
GO: 0043819
Genes
FAU: Fraau_1604
PMY: Pmen_4583
PMK: MDS_4923
PPSE: BN5_4394(cobF)
PALC: A0T30_08895
PCQ: PcP3B5_15360(sumT_1)
PMUI: G4G71_13890
PPU: PP_3763
PPF: Pput_2000
PPG: PputGB1_2140
PPT: PPS_3233
PPI: YSA_09357
PPX: T1E_3914(cobF)
PPUH: B479_16075
PPUT: L483_19690
PPUN: PP4_20250(cobF)
PPUD: DW66_3660
PMON: X969_15565
PMOT: X970_15210
PMOL: CLJ08_26250(cobF)
PSB: Psyr_2442
PSYR: N018_15080
PVD: CFBP1590__2569(cobF)
PFL: PFL_2249(cobF)
PPRC: PFLCHA0_c23110(cobF)
PPRO: PPC_2289(cobF)
PFS: PFLU_2445(cobF)
PFC: PflA506_2286(cobF)
PFB: VO64_5585
PMAN: OU5_5874
PFW: PF1751_v1c21430(cobF)
PEN: PSEEN3208
PPUU: PputUW4_03212(cobF)
PKC: PKB_1561(cobF)
PSES: PSCI_4761
PSEM: TO66_11290
PSEC: CCOS191_2416(cobF)
PSOS: POS17_2223(cobF)
PANR: A7J50_3325
PSIL: PMA3_17435
PALL: UYA_24390
PDW: BV82_3204(cobF)
PZE: HU754_018640(cobF)
PMOE: HV782_011650(cobF)
PSEP: C4K39_5780
PVW: HU752_017700(cobF)
PTRT: HU722_0012260(cobF)
PXA: KSS93_14140(cobF)
PSAM: HU731_027520(cobF)
PTZ: HU718_011855(cobF)
PQI: KH389_11035(cobF)
PSHH: HU773_011040(cobF)
PXN: HU772_013045(cobF)
PHV: HU739_007180(cobF)
PPRG: HU725_009480(cobF)
PANH: HU763_010390(cobF)
PASG: KSS96_12725(cobF)
PFAK: KSS94_14870(cobF)
PMUY: KSS95_14765(cobF)
PMAM: KSS90_11905(cobF)
PAZE: KSS91_10890(cobF)
PALV: KSS97_10760(cobF)
PORY: EJA05_11505(cobF)
PWZ: J7655_00750(cobF)
PTK: EXN22_12760(cobF)
PZA: HU749_011120(cobF)
PIE: HU724_011300(cobF)
PWY: HU734_012845(cobF)
ACX: Achr_f700(cobF)
ATEP: Atep_12110
HEL: HELO_1841(cobF)
HAM: HALO2061
HSR: HSBAA_38860(cobF)
GPB: HDN1F_26350(cobF)
BGU: KS03_4726(cobF)
BGO: BM43_5144(cobF)
BFN: OI25_4709(cobF)
PEW: KZJ38_17735(cobF)
CABA: SBC2_19040
PVAC: HC248_02548(cysG_2)
DAC: Daci_5843
CTES: O987_11725
CAQT: KAQ61_16525(cobF)
RGE: RGE_19270(cobF)
TTW: LCC91_06085(cobF)
MLO: mlr1461
MHUA: MCHK_3093
NKI: KW403_18520(cobF)
SME: SMc03194(cobF)
SMX: SM11_chr3097(cobF)
SMI: BN406_02781(cobF)
SMEL: SM2011_c03194(cobF)
SMER: DU99_16115
SMD: Smed_2819
RHI: NGR_c29820(cobF)
SFH: SFHH103_02989(cobF)
SFD: USDA257_c53980(cobF)
SIX: BSY16_3268(cobF)
SAME: SAMCFNEI73_Ch3354(cobF)
EAD: OV14_0450(cobF)
ARA: Arad_9597(cobF)
RET: RHE_PE00456(cobF)
REC: RHECIAT_PA0000379(cobF)
REL: REMIM1_PD00479(cobF)
REP: IE4803_PA00415(cobF)
REI: IE4771_PC00428(cobF)
RLE: pRL110632(cobF)
RLG: Rleg_7173
RTR: RTCIAT899_PC06985(cobF)
RHL: LPU83_pLPU83d0188(cobF)
RGA: RGR602_PC01217(cobF)
RHN: AMJ98_PD00465(cobF)
RPHA: AMC79_PB00388(cobF)
RHX: AMK02_PE00472(cobF)
RHK: Kim5_PB00448(cobF)
REZ: AMJ99_PC00466(cobF)
SHZ: shn_19595
SZO: K8M09_16575(cobF)
BJA: blr3275(cobF)
BRS: S23_47290(cobF)
BRAD: BF49_1423
BRK: CWS35_19655(cobF)
BOT: CIT37_37185(cobF)
BRQ: CIT40_10860(cobF)
BGQ: X265_24750(cobF)
BGZ: XH91_22790(cobF)
BSYM: CIT39_09840(cobF)
BBET: F8237_03775(cobF)
BARH: WN72_17885(cobF)
BVZ: BRAD3257_5424(cobF)
BEL: BE61_67470(cobF)
BDG: LPJ38_19190(cobF)
BSEP: HAP48_0032410(cobF)
BQB: J4P68_0033680(cobF)
RPA: RPA2097(cobF)
RPB: RPB_3174
RPC: RPC_1896
RPD: RPD_2326
RPE: RPE_2230
RPT: Rpal_2387
BOS: BSY19_866(cobF)
SNO: Snov_3866
MEA: Mex_1p3613(cobF)
MDI: METDI4188(cobF)
MEX: Mext_3385
MCH: Mchl_3694
MPO: Mpop_3576
MOR: MOC_1916(cobF)
META: Y590_16610
MOG: MMB17_18160(cobF)
MSL: Msil_3231
MTUN: MTUNDRAET4_2509(cobF)
BBAR: RHAL1_03664(cobF)
HDN: Hden_3043
HMC: HYPMC_4271(cobF)
RVA: Rvan_2495
FIL: BN1229_v1_3164(cobF)
FIY: BN1229_v1_2758(cobF)
PHL: KKY_930
DSAL: K1X15_04475(cobF)
BVR: BVIR_732
BLAG: BLTE_23750
AALM: LUX29_02440(cobF)
SIL: SPO2874(cobF)
JAN: Jann_2920
RDE: RD1_3816(cobF)
RLI: RLO149_c006280(cobF)
PGD: Gal_02686
LAQU: R2C4_04775
CID: P73_0481
MALG: MALG_01197
SINL: DSM14862_03161(cobI_1)
MALU: KU6B_33000(cobF)
RSP: RSP_2819(cobF)
CAZT: LV780_06890(cobF)
RCP: RCAP_rcc02038(cobF)
PDE: Pden_2542
PAMN: JCM7685_0429(cobF)
PMAU: CP157_03014(cobI_2)
RSU: NHU_02589(cobF)
RHC: RGUI_1457
GFU: KM031_03350(cobF)
GCE: KYE46_07770(cobF)
NAR: Saro_0332
SPHP: LH20_21900
STAX: MC45_16145
SJP: SJA_C2-03190(cobF)
SINB: SIDU_11790
SPMI: K663_18436
SPHB: EP837_03425(cobF)
SPHT: K426_22504
SPPH: KFK14_09740(cobF)
AMV: ACMV_P1_00520(cobF)
ASZ: ASN_3525(cobF)
RRU: Rru_A2970
RRF: F11_15215
PARH: I5S86_11900(cobF)
MCE: MCAN_09451(cobF)
MCQ: BN44_11038(cobF)
MCV: BN43_20416(cobF)
MCX: BN42_20755(cobF)
MCZ: BN45_20247(cobF)
MPA: MAP_0888
MAO: MAP4_2972
MAVI: RC58_14755
MAVU: RE97_14780
MAV: MAV_1065(cobF)
MIT: OCO_09330
MIA: OCU_09370
MID: MIP_01553
MYO: OEM_09530
MIR: OCQ_09460
MMAL: CKJ54_04640(cobF)
MLP: MLM_1015
MMAN: MMAN_52720(cobF)
MUL: MUL_4422
MMC: Mmcs_4338
MKM: Mkms_4424
MJL: Mjls_4718
MMI: MMAR_4563
MMM: W7S_04625
MHAD: B586_06230
MSHG: MSG_04097(cobF)
MFJ: MFLOJ_45580(cobF)
MSTO: MSTO_49510(cobF)
MSIM: MSIM_34630(cobF)
MSAK: MSAS_24480(cobF)
MKU: I2456_21755(cobF)
MXE: MYXE_12410(cobF)
MNV: MNVI_08040(cobF)
MNM: MNVM_28910(cobF)
MGOR: H0P51_23435(cobF)
MSEO: MSEO_28960(cobF)
MPSE: MPSD_47180(cobF)
MSHO: MSHO_20280(cobF)
MHEK: JMUB5695_01173(cobF)
MGAU: MGALJ_34200(cobF)
MLJ: MLAC_32170(cobF)
MBRD: MBRA_25400(cobF)
MKR: MKOR_38810(cobF)
MDF: K0O62_23760(cobF)
MMAM: K3U93_19920(cobF)
MHOL: K3U96_04840(cobF)
MHER: K3U94_17885(cobF)
MSEN: K3U95_23240(cobF)
MPAE: K0O64_23830(cobF)
MOT: LTS72_02365(cobF)
MSM: MSMEG_5548(cobF)
MVA: Mvan_0376
MGI: Mflv_0361
MPHL: MPHLCCUG_00906(cysG_1)
MVQ: MYVA_0347
MTHN: 4412656_03793(cobI_2)
MHAS: MHAS_03395
MDR: MDOR_30580(cobF)
MMAG: MMAD_09570
MMOR: MMOR_16060(cobF)
MFX: MFAL_36400(cobF)
MAIC: MAIC_09300(cobF)
MIJ: MINS_40120(cobF)
MALV: MALV_45940(cobF)
MTY: MTOK_27690(cobF)
MARZ: MARA_51550(cobF)
MGAD: MGAD_33070(cobF)
MHEV: MHEL_31870(cobF)
MSAR: MSAR_07850(cobF)
MANY: MANY_29410(cobF)
MAUB: MAUB_41320(cobF)
MPOF: MPOR_08720
MPHU: MPHO_28260(cobF)
MMAT: MMAGJ_09200(cobF)
MBOK: MBOE_24060(cobF)
MFG: K6L26_07540(cobF)
MSEI: MSEDJ_24710(cobF)
MAB: MAB_1037
MABB: MASS_1032
MCHE: BB28_05165
MSTE: MSTE_01008
MMIN: MMIN_08620(cobF)
ASD: AS9A_3591(cobF)
MPAK: MIU77_03530(cobF)
CDI: DIP0822
CDIP: ERS451417_00729(cobI)
CKP: ckrop_0458(cobF)
CPU: CPFRC_03170(cobF)
CPL: Cp3995_0640(cobF)
CPG: CP316_03290(cobF)
CPP: CpP54B96_0640(cobF)
CPK: CP1002_09965(cobF)
CPQ: CPC231_03170(cobF)
CPX: CPI19_08350(cobF)
CPZ: CpPAT10_0630(cobF)
COR: Cp267_0658(cobF)
COP: CP31_03525(cobF)
COD: Cp106_0614(cobF)
COS: Cp4202_0623(cobF)
COI: CPCIP5297_03315(cobF)
COE: CP258_03310(cobF)
COU: CP162_03195(cobF)
CPSE: CPTA_01180
CPSU: CPTB_00352
CPSF: CPTC_01171
CUL: CULC22_00685(cobF)
CUC: CULC809_00673(cobF)
CUN: Cul210932_0709(cobF)
CUS: CulFRC11_0678(cobF)
CUQ: Cul210931_0677(cobF)
CUZ: Cul05146_0729(cobF)
CUJ: CUL131002_0686(cobF)
COA: DR71_626(cobF)
CKU: UL82_08555(cobF)
CEI: CEPID_03775(cobF)
CAQU: CAQU_00675
CPEG: CPELA_07765(cobI)
CGK: CGERO_03345(cobI)
CPSO: CPPEL_08000(cobI)
NFA: NFA_50210
NCY: NOCYR_4786(cobF)
NSR: NS506_01475(cobF)
NIE: KV110_36965(cobF)
NTC: KHQ06_10170(cobF)
NYA: LTV02_23485(cobF)
NGP: LTT66_17135(cobF)
RER: RER_44600(cobF)
REY: O5Y_20955
ROP: ROP_19610(cobF)
REQ: REQ_11090(cobF)
RHB: NY08_3904
RRT: 4535765_03937(cbiL)
RCR: NCTC10994_03362(cbiL)
RGO: KYT97_29465(cobF)
GBR: Gbro_1321
GPO: GPOL_c38500(cobF)
GOR: KTR9_1234
GOI: LK459_03865(cobF)
SPIN: KV203_15310(cobF)
TPR: Tpau_3353
SCO: SCO6971(SC6F7.24c)
SALB: XNR_5616
SMA: SAVERM_1600(cobF)
SGR: SGR_1214
SGB: WQO_29245
SHY: SHJG_7698
SVE: SVEN_5566
SDV: BN159_1551(cobF)
SALS: SLNWT_6775
SFI: SFUL_6267
SLV: SLIV_04395(cobF)
SGU: SGLAU_28590(cobF)
STRM: M444_06910
SAMB: SAM23877_6460(cobF)
SLE: sle_08880(sle_08880)
SCAD: DN051_08270(cobF)
STRD: NI25_04350
SALF: SMD44_07530(cobF) SMD44_07531(cobF)
SFK: KY5_7945
SNZ: DC008_29920(cobF)
SRJ: SRO_1128
SLK: SLUN_34390(cobF)
SDX: C4B68_04395(cobF)
SGD: ELQ87_04970(cobF)
SCYA: EJ357_40915(cobF)
SAST: CD934_03010(cobF)
SNQ: CP978_30190(cobF)
SHAW: CEB94_35890(cobF)
SGAL: CP966_31370(cobF)
SFY: GFH48_07865(cobF)
SAQU: EJC51_39850(cobF)
SSEO: D0Z67_25300(cobF)
SFUG: CNQ36_03845(cobF)
SCHA: CP983_05475(cobF)
SSPB: CP982_34740(cobF)
SBRO: GQF42_37855(cobF)
SATA: C5746_36300(cobF)
SCHF: IPT68_32020(cobF)
SFEU: IM697_27875(cobF)
SVD: CP969_32535(cobF)
SROI: IAG44_05965(cobF)
SDD: D9753_04805(cobF)
SACT: DMT42_32760(cobF)
LMOI: VV02_21350
ALX: LVQ62_01985(cobF)
PAC: PPA1920
PAK: HMPREF0675_4977(cobF)
PAW: PAZ_c20000(cobF)
PACC: PAC1_09815
PACH: PAGK_1835
CACN: RN83_09890
CGRN: 4412665_00095(cbiL)
ARUB: J5A65_09670(cobF)
AJI: C0Z10_08390(cobF)
MPH: MLP_03920(cobF)
BRT: J4N02_10860(cobF)
NCA: Noca_2879
NDK: I601_3855
NRO: K8W59_15995(cobF)
PSIM: KR76_17145
MGG: MPLG2_3517(cobF)
KFL: Kfla_5080
TFU: Tfu_0320
NDA: Ndas_1612
NAL: B005_0624(cobF)
NGN: LCN96_34330(cobF)
TBI: Tbis_2504
FAL: FRAAL2802
NML: Namu_0142
AMD: AMED_6899(cobF)
AMN: RAM_35395
AMM: AMES_6793(cobF)
AMZ: B737_6793(cobF)
AOI: AORI_1819(cobF)
AJA: AJAP_30370(cobF)
AMYY: YIM_40460(sumT)
AORI: SD37_32115
PDX: Psed_2708
PSEA: WY02_07005
PSEE: FRP1_06980
PSEH: XF36_07800
PAUT: Pdca_43880
AMI: Amir_4201
SESP: BN6_35150(cobF)
MIL: ML5_4315
ASE: ACPL_6895(cobF)
ACTN: L083_6529(cobF)
AFS: AFR_33965
ACTS: ACWT_6764
CAI: Caci_6988
AQZ: KSP35_16070(cobF)
ABAS: ACPOL_5058
CTHI: THC_0078
 » show all
LinkDB

KEGG   ENZYME: 2.1.1.152
Entry
EC 2.1.1.152                Enzyme                                 
Name
precorrin-6A synthase (deacetylating);
precorrin-6X synthase (deacetylating);
CobF
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)
Reaction(IUBMB)
S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate [RN:R05219]
Reaction(KEGG)
R05219
Substrate
S-adenosyl-L-methionine [CPD:C00019];
precorrin 5 [CPD:C06416];
H2O [CPD:C00001]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
precorrin 6A [CPD:C06320];
acetate [CPD:C00033]
Comment
The enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosythesis pathway, catalyses two reactions -the methylation of carbon C1 of precorrin-5, and its deacetylation, forming precorrin-6A. See EC 2.1.1.195, cobalt-precorrin-5B (C1)-methyltransferase, for the C1-methyltransferase that participates in the anaerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.152 created 2004
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
Orthology
K02228  precorrin-6A synthase
Genes
FAUFraau_1604
PMYPmen_4583
PMKMDS_4923
PPSEBN5_4394(cobF)
PALCA0T30_08895
PCQPcP3B5_15360(sumT_1)
PMUIG4G71_13890
PPUPP_3763
PPFPput_2000
PPGPputGB1_2140
PPWPputW619_2104
PPTPPS_3233
PPBPPUBIRD1_1999
PPIYSA_09357
PPXT1E_3914(cobF)
PPUHB479_16075
PPUTL483_19690
PPUNPP4_20250(cobF)
PPUDDW66_3660
PFVPsefu_2670
PMONX969_15565
PMOTX970_15210
PMOSO165_008570
PPJRK21_01404
PORAPT59_06440
PMOLCLJ08_26250(cobF)
PSTPSPTO_2709
PSBPsyr_2442
PSYRN018_15080
PSPPSPPH_2598
PSAVPSA3335_16725
PCIPCH70_22220
PAVLBKM03_15695
PVDCFBP1590__2569(cobF)
PCABJGS08_14020
PFLPFL_2249(cobF)
PPRCPFLCHA0_c23110(cobF)
PPROPPC_2289(cobF)
PFEPSF113_3866
PFNHZ99_00350
PFOPfl01_2061
PFSPFLU_2445(cobF)
PFCPflA506_2286(cobF)
PPZH045_07065
PFBVO64_5585
PMANOU5_5874
PTVAA957_02620
PCGAXG94_25345
PVRPverR02_18755
PAZOAYR47_18930
POIBOP93_10285
PRXHRH33_11580
PFWPF1751_v1c21430(cobF)
PFFPFLUOLIPICF725990
PFXA7318_10185
PENPSEEN3208
PBAPSEBR_a1862
PBCCD58_20130
PPUUPputUW4_03212(cobF)
PSVPVLB_15230
PSKU771_12900
PKCPKB_1561(cobF)
PCHEY04_10315
PCZPCL1606_38920
PCPJM49_19590
PFZAV641_11370
PLQAA042_20350
PALKPSAKL28_21660
PRHLT40_06830
PSWLK03_18665
PPVNJ69_05115
PSESPSCI_4761
PSEMTO66_11290
PSECCCOS191_2416(cobF)
PPSYAOC04_08450
PSOSPOS17_2223(cobF)
PKRAYO71_13425
PFKPFAS1_22430
PANRA7J50_3325
PPSLBJP27_21195
PSILPMA3_17435
PYMAK972_2313
PKEDLD99_10955
PALLUYA_24390
PUMHGP31_12620
POJPtoMrB4_08760
PGGFX982_04379
PPSHG5J76_14545
PGYAWU82_18505
PSEJHNQ25_01695
PVKEPZ47_10105
PEZHWQ56_20205
PBZGN234_07915
PKHJLK41_25145
PTYJWV26_09850
PATAJWU58_16800
PDWBV82_3204(cobF)
PZEHU754_018640(cobF)
PMOEHV782_011650(cobF)
PCAMHNE05_10500
PSEPC4K39_5780
PVWHU752_017700(cobF)
PTRTHU722_0012260(cobF)
PXAKSS93_14140(cobF)
PSAMHU731_027520(cobF)
PTZHU718_011855(cobF)
PQIKH389_11035(cobF)
PSHHHU773_011040(cobF)
PXNHU772_013045(cobF)
PHVHU739_007180(cobF)
PPRGHU725_009480(cobF)
PANHHU763_010390(cobF)
PASGKSS96_12725(cobF)
PFAKKSS94_14870(cobF)
PMUYKSS95_14765(cobF)
PMAMKSS90_11905(cobF)
PAZEKSS91_10890(cobF)
PALVKSS97_10760(cobF)
PORYEJA05_11505(cobF)
PWZJ7655_00750(cobF)
PTKEXN22_12760(cobF)
PZAHU749_011120(cobF)
PIEHU724_011300(cobF)
PWYHU734_012845(cobF)
PTAENCTC10697_02199
ACXAchr_f700(cobF)
ALVAlvin_2225
ATEPAtep_12110
TVIThivi_1710
TMBThimo_0503
MPURMARPU_05955
TTPE6P07_07700
CJAPGWK36_10125
GAIIMCC3135_08975
HELHELO_1841(cobF)
HCSFF32_13165
HAMHALO2061
HHUAR456_07035
HALOBWR19_06675
HALKCUU95_16980
HVNEI420_07575
HOLHORIV_40460
HSRHSBAA_38860(cobF)
HTTHZS52_14845
HSVHNO53_14275
ZPLZBT109_2265
HAAA5892_07930
GPBHDN1F_26350(cobF)
BGLbglu_2g11970
BGUKS03_4726(cobF)
BGDbgla_2g14740
BGOBM43_5144(cobF)
BGPBGL_2c13580
BPLAbpln_2g14280
BUMAXG89_37035
BUIAX768_15560
BFNOI25_4709(cobF)
PARABTO02_06290
PMEGFNZ07_28910
PTROG5S35_21285
PACPFAZ97_23205
PACSFAZ98_18570
PEWKZJ38_17735(cobF)
PVEUC34_18550
PFGAB870_05565
PLGNCTC10937_02462
CABASBC2_19040
RSBRS694_10940
RACRA876_02040
RHYRD110_04600
RHGEXZ61_08035
PVACHC248_02548(cysG_2)
AANTHUK68_04440
DACDaci_5843
DELDelCs14_0756
DTSBI380_25875
DHKBO996_27395
DLAI6G47_26445
CTTCtCNB1_1870
CTESO987_11725
CSERCCO03_13810
CAQTKAQ61_16525(cobF)
DIHG7047_04475
DAERH9K75_21175
DRGH9K76_03120
RGERGE_19270(cobF)
RBNRBXJA2T_11802
TTWLCC91_06085(cobF)
RBHB4966_14525
ZPAC3497_13865
DEOCAY53_08560
MLOmlr1461
MLNA9174_18825
MCIMesci_3221
MOPMesop_3612
MAMMesau_03486
MAMOA6B35_22645
MESWA9K65_017445
MESMEJ066_26500
MESPC1M53_22885 C1M53_23370
MHUAMCHK_3093
MJREB229_19110
MERDEB233_16440
MESRFGU64_05965
MESOBSQ44_06430
AAKAA2016_0188
NIYFQ775_15175
NKIKW403_18520(cobF)
PMOBHG718_00605
SMESMc03194(cobF)
SMKSinme_2979
SMQSinmeB_2754
SMXSM11_chr3097(cobF)
SMIBN406_02781(cobF)
SMEGC770_GR4Chr3054
SMELSM2011_c03194(cobF)
SMERDU99_16115
SMDSmed_2819
RHINGR_c29820(cobF)
SFHSFHH103_02989(cobF)
SFDUSDA257_c53980(cobF)
SIXBSY16_3268(cobF)
SAMESAMCFNEI73_Ch3354(cobF)
SINOSS05631_c27810
EADOV14_0450(cobF)
EAHFA04_15865
ESJSJ05684_c29400
EAKEKH55_2877
EMXFKV68_18430
ARAArad_9597(cobF)
RETRHE_PE00456(cobF)
RECRHECIAT_PA0000379(cobF)
RELREMIM1_PD00479(cobF)
REPIE4803_PA00415(cobF)
REIIE4771_PC00428(cobF)
RLEpRL110632(cobF)
RLTRleg2_6018
RLGRleg_7173
RLBRLEG3_05760
RLURLEG12_01455
RTRRTCIAT899_PC06985(cobF)
RHLLPU83_pLPU83d0188(cobF)
RGARGR602_PC01217(cobF)
RHNAMJ98_PD00465(cobF)
RPHAAMC79_PB00388(cobF)
RHXAMK02_PE00472(cobF)
RHKKim5_PB00448(cobF)
REZAMJ99_PC00466(cobF)
RJGCCGE525_29340
RHRCKA34_23610
RGRFZ934_26150
RADCO657_32025
RIIFFM53_030975
RHIDFFM81_030450
RBQJ2J99_29220
RLNJ0663_26680
RBANJ2J98_26065
RRGJ3P73_31275
RLSHB780_04975
SHZshn_19595
SZOK8M09_16575(cobF)
BJAblr3275(cobF)
BJUBJ6T_64750
BJPRN69_31385
BRSS23_47290(cobF)
BRCBCCGELA001_14750
BRADBF49_1423
BICLMTR13_27075
BRKCWS35_19655(cobF)
BOTCIT37_37185(cobF)
BRQCIT40_10860(cobF)
BGQX265_24750(cobF)
BGZXH91_22790(cobF)
BSYMCIT39_09840(cobF)
BBETF8237_03775(cobF)
BARHWN72_17885(cobF)
BVZBRAD3257_5424(cobF)
BELBE61_67470(cobF)
BDGLPJ38_19190(cobF)
BSEPHAP48_0032410(cobF)
BQBJ4P68_0033680(cobF)
RPARPA2097(cobF)
RPBRPB_3174
RPCRPC_1896
RPDRPD_2326
RPERPE_2230
RPTRpal_2387
RPXRpdx1_3417
TRBHB776_31185
BOSBSY19_866(cobF)
BVVBHK69_21020
BOIBLM15_12210
BOFFQV39_16615
SNOSnov_3866
STARG3545_18425
ANCGBB76_13140
APRAG3A50_09825
MEAMex_1p3613(cobF)
MDIMETDI4188(cobF)
MEXMext_3385
MCHMchl_3694
MPOMpop_3576
MZAB2G69_24485
MRDMrad2831_1538
MORMOC_1916(cobF)
METAY590_16610
MPHYMCBMB27_01182
METDC0214_18575
METXA3862_23160
METSDK389_26580
METIDK427_17680
MMESMMSR116_01780
MOGMMB17_18160(cobF)
MSLMsil_3231
MTUNMTUNDRAET4_2509(cobF)
MLGCWB41_06605
BBARRHAL1_03664(cobF)
CHELAL346_23850
CDQBOQ54_19015
HDNHden_3043
HDTHYPDE_38363
HMCHYPMC_4271(cobF)
HNIW911_07150
RVARvan_2495
FILBN1229_v1_3164(cobF)
FIYBN1229_v1_2758(cobF)
RHZRHPLAN_54820
METGHT051_12350
NTDEGO55_18845
PHLKKY_930
DEIC4375_01910
DEAFPZ08_01605
DSALK1X15_04475(cobF)
BVRBVIR_732
BLAGBLTE_23750
MBRYB1812_16085
MTWCQW49_09630
PLEOOHA_1_04094
AALAIGS74_02360
AALMLUX29_02440(cobF)
NOHG5V57_19705
PPHRAPZ00_04925
PHRC6569_16555
PSTGE8M01_31185
SILSPO2874(cobF)
SITTM1040_2224
RUAD1823_08555
RUTFIU92_04730
JANJann_2920
RDERD1_3816(cobF)
RLIRLO149_c006280(cobF)
RPONG3256_12300
PGAPGA1_c08050
PGLPGA2_c07820
PGDGal_02686
PHPPhaeoP97_00771
PPICPhaeoP14_00726
PHQD1820_17135
LMDMETH_04200
LEJETW24_14140
LAQUR2C4_04775
REDroselon_02169
CIDP73_0481
MALGMALG_01197
CONTQ29_16380
YPACCEW88_21565
TPROGa0080559_TMP4834
PABYGa0080574_TMP1476
SUAMBOO69_17160
SULZC1J03_01485
SULDB5M07_16100
SPOTG6548_14705
SMEDJNX03_14300
SINLDSM14862_03161(cobI_1)
SPSESULPSESMR1_02801
TOMBWR18_11005
ROHFIU89_17390
AHTANTHELSMS3_02556
SAGUCDO87_15480
THAACFI11_03830
MARUFIU81_13745
MALUKU6B_33000(cobF)
RSPRSP_2819(cobF)
RSHRsph17029_1477
RSQRsph17025_1527
RSKRSKD131_1144
CAZTLV780_06890(cobF)
RCPRCAP_rcc02038(cobF)
RHPLPB142_02435
RBLB6K69_04395
PDEPden_2542
PAMIJCM7686_1176
PYEA6J80_00280
PCONB0A89_04470
PZHCX676_20010
PAROCUV01_00655
PAMNJCM7685_0429(cobF)
PARREOJ32_02875
PKDF8A10_01330
PPANESD82_11540
PLIAE4191_00870
PSANHGN31_15850
PMAUCP157_03014(cobI_2)
RSUNHU_02589(cobF)
RHMB5V46_10795
RHCRGUI_1457
RMBK529_002740
DAAAKL17_0054
RBGBG454_16705
GEHHYN69_05215 HYN69_20030
GFUKM031_03350(cobF)
TAWEI545_12835
SALOEF888_09305
SEDIEBB79_05365
HMLHmaOT1_14700
BOOE2K80_13885
PSEBEOK75_19620
MONG8E03_05225
POZI0K15_06345
CACTHZ995_01250
GCEKYE46_07770(cobF)
NARSaro_0332
NPPPP1Y_AT19889
NPNJI59_17250
NREBES08_17795
NOVTQ38_023190
NORFA702_01450
SPHPLH20_21900
STAXMC45_16145
SPANAWL63_14890
SPLKAV944_15440
SPHAD3Y57_03050
SPAUDRN02_016930
SJPSJA_C2-03190(cobF)
SINBSIDU_11790
SCHSphch_3756
SYBTZ53_06760
SBDATN00_04715
SPMIK663_18436
SPHBEP837_03425(cobF)
SPHTK426_22504
SYAA6768_25085
SBARH5V43_18210
SPPHKFK14_09740(cobF)
AMVACMV_P1_00520(cobF)
ASZASN_3525(cobF)
ATOCIW82_13900
ACEKFLP30_11330
KBAA0U89_06100
RRURru_A2970
RRFF11_15215
RPMRSPPHO_00629
FERFNB15_20495
PARHI5S86_11900(cobF)
MCEMCAN_09451(cobF)
MCQBN44_11038(cobF)
MCVBN43_20416(cobF)
MCXBN42_20755(cobF)
MCZBN45_20247(cobF)
MPAMAP_0888
MAOMAP4_2972
MAVIRC58_14755
MAVURE97_14780
MAVMAV_1065(cobF)
MITOCO_09330
MIAOCU_09370
MIDMIP_01553
MYOOEM_09530
MCHIAN480_05840
MIROCQ_09460
MMALCKJ54_04640(cobF)
MLPMLM_1015
MMANMMAN_52720(cobF)
MSAMycsm_05301
MULMUL_4422
MMCMmcs_4338
MKMMkms_4424
MJLMjls_4718
MMIMMAR_4563
MMAEMMARE11_43760
MMMW7S_04625
MLIMULP_04780
MKNMKAN_09045
MYVG155_06755
MYEAB431_24145
MGOAFA91_12930 AFA91_20070
MHADB586_06230
MDXBTO20_29060
MSHGMSG_04097(cobF)
MFJMFLOJ_45580(cobF)
MSTOMSTO_49510(cobF)
MSIMMSIM_34630(cobF)
MSAKMSAS_24480(cobF)
MKUI2456_21755(cobF)
MGROFZ046_14310
MXEMYXE_12410(cobF)
MNVMNVI_08040(cobF)
MPAGC0J29_25155
MNMMNVM_28910(cobF)
MGORH0P51_23435(cobF)
MBAIMB901379_03997
MSEOMSEO_28960(cobF)
MPSEMPSD_47180(cobF)
MSHOMSHO_20280(cobF)
MHEKJMUB5695_01173(cobF)
MGAUMGALJ_34200(cobF)
MLJMLAC_32170(cobF)
MBRDMBRA_25400(cobF)
MKRMKOR_38810(cobF)
MDFK0O62_23760(cobF)
MMAMK3U93_19920(cobF)
MHOLK3U96_04840(cobF)
MHERK3U94_17885(cobF)
MSENK3U95_23240(cobF)
MPAEK0O64_23830(cobF)
MSPGF6B93_18405
MOTLTS72_02365(cobF)
MSMMSMEG_5548(cobF)
MSGMSMEI_5395
MSBLJ00_27425
MSNLI99_27430
MSHLI98_27435
MVAMvan_0376
MGIMflv_0361
MSPMspyr1_03950
MCBMycch_0301
MNED174_22595
MYNMyAD_22155
MFTXA26_13490
MPHLMPHLCCUG_00906(cysG_1)
MVQMYVA_0347
MLLB1R94_23355
MRHMycrhN_3302
MTHN4412656_03793(cobI_2)
MHASMHAS_03395
MDUMDUV_39920
MCHTMCHIJ_11930
MDRMDOR_30580(cobF)
MAUUNCTC10437_00331
MMAGMMAD_09570
MMORMMOR_16060(cobF)
MFXMFAL_36400(cobF)
MAICMAIC_09300(cobF)
MIJMINS_40120(cobF)
MALVMALV_45940(cobF)
MTYMTOK_27690(cobF)
MPSCMPSYJ_05780
MARZMARA_51550(cobF)
MGADMGAD_33070(cobF)
MHEVMHEL_31870(cobF)
MSARMSAR_07850(cobF)
MANYMANY_29410(cobF)
MAUBMAUB_41320(cobF)
MPOFMPOR_08720
MPHUMPHO_28260(cobF)
MMUCC1S78_004215
MMATMMAGJ_09200(cobF)
MBOKMBOE_24060(cobF)
MFGK6L26_07540(cobF)
MSEIMSEDJ_24710(cobF)
MFLVNCTC10271_00875
MABMAB_1037
MMVMYCMA_0548
MABBMASS_1032
MABLMMASJCM_1063
MCHEBB28_05165
MIZBAB75_05525
MSTEMSTE_01008
MSAOMYCSP_04470
MSALDSM43276_00909
MJDJDM601_3179
MTER4434518_03164
MMINMMIN_08620(cobF)
ASDAS9A_3591(cobF)
MPAKMIU77_03530(cobF)
CDIDIP0822
CDPCD241_0736
CDHCDB402_0709
CDTCDHC01_0735
CDECDHC02_0736
CDRCDHC03_0735
CDACDHC04_0743
CDZCD31A_0833
CDBCDBH8_0779
CDSCDC7B_0743
CDDCDCE8392_0734
CDWCDPW8_0794
CDVCDVA01_0702
CDIPERS451417_00729(cobI)
CKPckrop_0458(cobF)
CPUCPFRC_03170(cobF)
CPLCp3995_0640(cobF)
CPGCP316_03290(cobF)
CPPCpP54B96_0640(cobF)
CPKCP1002_09965(cobF)
CPQCPC231_03170(cobF)
CPXCPI19_08350(cobF)
CPZCpPAT10_0630(cobF)
CORCp267_0658(cobF)
COPCP31_03525(cobF)
CODCp106_0614(cobF)
COSCp4202_0623(cobF)
COICPCIP5297_03315(cobF)
COECP258_03310(cobF)
COUCP162_03195(cobF)
CPSECPTA_01180
CPSUCPTB_00352
CPSFCPTC_01171
CULCULC22_00685(cobF)
CUCCULC809_00673(cobF)
CUECULC0102_0783
CUNCul210932_0709(cobF)
CUSCulFRC11_0678(cobF)
CUQCul210931_0677(cobF)
CUZCul05146_0729(cobF)
CUJCUL131002_0686(cobF)
CAZCARG_02415
CVTB843_04335
COADR71_626(cobF)
CKUUL82_08555(cobF)
CMVCMUST_04795
CEICEPID_03775(cobF)
CLWCLAC_09625
CAQUCAQU_00675
CSPHCSPHI_09680
CPEGCPELA_07765(cobI)
CXEFOB82_02880
CGKCGERO_03345(cobI)
CRFFRC0190_00785
CCHOCCHOA_03185
CPSOCPPEL_08000(cobI)
CMATHBA49_10600
CAMCI6I65_05360
CGLUI6J20_06025
CSILCBE74_03945
CKWCKALI_08615
CORYFQV43_02770
NFANFA_50210
NFRERS450000_04877
NCYNOCYR_4786(cobF)
NBRO3I_037795
NNONONO_c68260
NSLBOX37_28725
NSRNS506_01475(cobF)
NTPCRH09_35705
NOZDMB37_16580
NODFOH10_00960
NAHF5544_40325
NADNCTC11293_06388
NWLNWFMUON74_63840
NIEKV110_36965(cobF)
NTCKHQ06_10170(cobF)
NHUH0264_09475
NYALTV02_23485(cobF)
NGPLTT66_17135(cobF)
RHARHA1_ro02247
RERRER_44600(cobF)
REYO5Y_20955
REBXU06_21120
RQIC1M55_22465
ROPROP_19610(cobF)
ROAPd630_LPD06429
REQREQ_11090(cobF)
RPYY013_10485 Y013_14605
RBYCEJ39_21275
RHBNY08_3904
RAVAAT18_20415
RFAA3L23_02019
RHSA3Q41_01344
RHWBFN03_13470
RRZCS378_09885
RHUA3Q40_02648
RHQIM25_02225
RHODAOT96_02510
RRT4535765_03937(cbiL)
RCRNCTC10994_03362(cbiL)
RTMG4H71_05530
RKOJWS14_11715
RGOKYT97_29465(cobF)
GBRGbro_1321
GPOGPOL_c38500(cobF)
GORKTR9_1234
GOQACH46_17975
GTABCM27_07190
GOCCXX93_18040
GITC6V83_04945
GRUGCWB2_06720
GOMD7316_01892
GAVC5O27_21045
GODGKZ92_06365
GAMGII34_06110
GPDGII33_05470
GJIH1R19_06490
GOILK459_03865(cobF)
SPINKV203_15310(cobF)
TPRTpau_3353
TSMASU32_04675
DTMBJL86_2353
DITC3V38_05585
DIZCT688_01025
DPCA6048_01070
DLUA6035_16350
SCOSCO6971(SC6F7.24c)
SALBXNR_5616
SMASAVERM_1600(cobF)
SGRSGR_1214
SGBWQO_29245
SHYSHJG_7698
SHOSHJGH_7460
SVESVEN_5566
SDVBN159_1551(cobF)
SALSSLNWT_6775
SFISFUL_6267
SCIB446_31065
SLVSLIV_04395(cobF)
SGUSGLAU_28590(cobF)
SCWTU94_29510
STRMM444_06910
SAMBSAM23877_6460(cobF)
SCZABE83_05005
SCXAS200_08605
SRWTUE45_07369
STRFASR50_30725
SLEsle_08880(sle_08880)
SPAVSpa2297_28410
STRTA8713_27840
SCLFBB341_28835
SGSAVL59_15395
STSIA4E84_35020
SKYD0C37_30160
SCADDN051_08270(cobF)
SLSSLINC_7259
SPLULK06_028820
STRDNI25_04350
SNWBBN63_04015
SVUB1H20_30125
SPUNBFF78_06080
SALFSMD44_07530(cobF) SMD44_07531(cobF)
SLXSLAV_07065
SFKKY5_7945
SNZDC008_29920(cobF)
SGEDWG14_01351
SRJSRO_1128
SLKSLUN_34390(cobF)
SDXC4B68_04395(cobF)
SGDELQ87_04970(cobF)
SQZFQU76_30550
SCYAEJ357_40915(cobF)
SASTCD934_03010(cobF)
SNQCP978_30190(cobF)
SKACP970_42745
SGZC0216_11475
SVNCP980_05595
SHAWCEB94_35890(cobF)
SGALCP966_31370(cobF)
SSPODDQ41_27060
SPADDVK44_31185
SFYGFH48_07865(cobF)
SAQUEJC51_39850(cobF)
SGFHEP81_01096
SCAVCVT27_28755
SSEOD0Z67_25300(cobF)
SSUBCP968_06160
SFUGCNQ36_03845(cobF)
SPACB1H29_05180
STSUB7R87_30240
SCHACP983_05475(cobF)
SSPBCP982_34740(cobF)
SNFJYK04_06932
SBROGQF42_37855(cobF)
STUIGCM10017668_61670
SATAC5746_36300(cobF)
SCHFIPT68_32020(cobF)
SCYGS1361_33525
SFEUIM697_27875(cobF)
SLIAHA039_03715
SVDCP969_32535(cobF)
SCALI6J39_29930
SROIIAG44_05965(cobF)
SGJIAG43_24430
SDDD9753_04805(cobF)
SACTDMT42_32760(cobF)
KABB7C62_31380
STRIC7M71_029300
DNIHX89_07885
DAYFV141_07095
LMOIVV02_21350
ALXLVQ62_01985(cobF)
ICAIntca_0163 Intca_0799
JTEASJ30_05395
JLIEXU32_09385
JMEEEW87_009500
TEHGKE56_09785
PEIH9L10_03930
SERWFY030_12820
DCOSAMEA4475696_0909
PACPPA1920
PAKHMPREF0675_4977(cobF)
PAVTIA2EST22_09390
PAXTIA2EST36_09370
PAZTIA2EST2_09330
PAWPAZ_c20000(cobF)
PADTIIST44_02385
PCNTIB1ST10_09795
PACCPAC1_09815
PACHPAGK_1835
PACNTIA1EST1_09455
CACNRN83_09890
PRAPALO_01390
PRLBCB70_08815
CGRN4412665_00095(cbiL)
ARUBJ5A65_09670(cobF)
PBOPACID_13000
AACIASQ49_14695
ACIJJS278_02025
AJIC0Z10_08390(cobF)
MPHMLP_03920(cobF)
TFLRPIT_05220
TFABW733_00230
TESBW730_04760
TEZBKM78_01595 BKM78_14765
TLATLA_TLA_00323 TLA_TLA_02971
RAINRai3103_07695
PRVG7070_09105
BRTJ4N02_10860(cobF)
NCANoca_2879
NDKI601_3855
NSNEXE58_16795
NBEBack2_04860
NANOG5V58_13380
NAROCFH99_15785
NPIG7071_10155
NAQUENKNEFLB_00261 ENKNEFLB_01612(cobI)
NROK8W59_15995(cobF)
PSIMKR76_17145
AERAERYTH_14735
AEZC3E78_16180
AEBC6I20_00075 C6I20_00430
MGGMPLG2_3517(cobF)
KFLKfla_5080
KQIF1D05_07820
TFUTfu_0320
THAONI17_022120
NDANdas_1612
NALB005_0624(cobF)
ACTWF7P10_02560
NOABKM31_07085
NGNLCN96_34330(cobF)
TBITbis_2504
FRAFrancci3_2657
FRIFraEuI1c_0482
FALFRAAL2802
NMLNamu_0142
NAKEH165_13570
SVISvir_17580
AMDAMED_6899(cobF)
AMNRAM_35395
AMMAMES_6793(cobF)
AMZB737_6793(cobF)
AOIAORI_1819(cobF)
AJAAJAP_30370(cobF)
AMYCCU254_27930
AMYBBKN51_01310
AABA4R43_37610
AMYYYIM_40460(sumT)
AORISD37_32115
PDXPsed_2708
PSEAWY02_07005
PSEEFRP1_06980
PSEHXF36_07800
PSEQAD006_14600
PECQAD017_22425
PHHAFB00_22440
PAUTPdca_43880
PBROHOP40_19290
APRECNX65_21025
AMIAmir_4201
SESPBN6_35150(cobF)
KPHYAOZ06_10375
LEDBBK82_20130
PMADBAY61_18585
MILML5_4315
MICBMicB006_3144
MTUACSH63_04895
MSAGGCM10017556_51670
MCRAID554_30000
ASEACPL_6895(cobF)
AMSAMIS_66340
ACTNL083_6529(cobF)
AFSAFR_33965
ACTSACWT_6764
AIHAiant_27400
PLABC6361_08380
PLATC6W10_04935
PFLAPflav_045930
PSUUPsuf_066040
VERHUT12_15055
DVCDvina_46370
NHYJQS43_13800
CAICaci_6988
EKEEK0264_05850
BSOLFSW04_05160
AQZKSP35_16070(cobF)
ACMAciX9_3952
GMAAciX8_1802
ABASACPOL_5058
DTPJZK55_23250
CTHITHC_0078
NFTFBF37_00960
HNOLT974_03625
 » show all
Reference
1  [PMID:8226690]
  Authors
Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F
  Title
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
  Journal
J Bacteriol 175:7430-40 (1993)
DOI:10.1128/JB.175.22.7430-7440.1993
Reference
2  [PMID:12195810]
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
DOI:10.1039/b108967f
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.152
IUBMB Enzyme Nomenclature: 2.1.1.152
ExPASy - ENZYME nomenclature database: 2.1.1.152
BRENDA, the Enzyme Database: 2.1.1.152
LinkDB

KEGG   REACTION: R05219
Entry
R05219                      Reaction                               
Definition
Precorrin 6X + Acetate + S-Adenosyl-L-homocysteine <=> Precorrin 5 + S-Adenosyl-L-methionine + H2O
Equation
Reaction class
RC00003  C00019_C00021
RC00923  C00033_C06416
RC02890  C06320_C06416
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00925  Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
Orthology
K02228  precorrin-6A synthase [EC:2.1.1.152]
Other DBs
RHEA: 18264
LinkDB

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