Entry
Name
adenosylcobyric acid synthase (glutamine-hydrolysing);
CobQ;
cobyric acid synthase;
5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase;
Ado-cobyric acid synthase [glutamine hydrolyzing]
Class
Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor
BRITE hierarchy
Sysname
adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)
Reaction(IUBMB)
4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate [RN:
R05225 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Mg2+. NH3 can act instead of glutamine. This enzyme catalyses the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates.
History
EC 6.3.5.10 created 2004
Pathway
Orthology
K02232 adenosylcobyric acid synthase
Genes
RTG : NCTC13098_01305(cobQ)
REE : electrica_00893(cobQ)
KIE : NCTC12125_04878(cobQ_1) NCTC12125_04879(cobQ_2)
BUF : D8682_20895 D8682_24280
METY : MRY16398_18790(cobQ)
AHN : NCTC12129_00860(cbiP)
PSHI : SAMEA2665130_0605(cobQ)
EIC : NT01EI_1850 NT01EI_2180
ETR : ETAE_1848(cbiP1) ETAE_1989(cbiP2)
ETD : ETAF_1667 ETAF_1798(cbiO)
ETE : ETEE_3895(cobQ) ETEE_4047(cobQ)
ETC : ETAC_08470 ETAC_09090
EDW : QY76_10315 QY76_11035
HAV : AT03_05715 AT03_08680
OPO : DSM2777_13935 DSM2777_20745
LRI : NCTC12151_01593(cobQ)
XFU : XFF4834R_chr14420(cobQ)
XPH : XppCFBP6546_18105(XppCFBP6546P_18105)
VCE : Vch1786_II0412(cobQ)
VAU : VANGNB10_cII0675c(cobQ)
VZI : G5S32_07565 G5S32_19650
PAEB : NCGM1900_5297(cobQ)
PPUD : DW66_1250 DW66_1612
PVD : CFBP1590__1588(cobQ)
PPRC : PFLCHA0_c44990(cobQ)
PFW : PF1751_v1c39800(cobQ)
PPUU : PputUW4_03770(cobQ)
PTW : TUM18999_41210(cobQ)
PTAE : NCTC10697_01156(cobQ)
SLJ : EGC82_06050 EGC82_11300
SCAA : TUM17387_32350(cobQ)
MESL : KKZ03_12295 KKZ03_16880
TMB : Thimo_0473 Thimo_0484 Thimo_3406
HHK : HH1059_08900(cobQ_1) HH1059_08960 HH1059_09380(cobQ_2)
HHC : M911_01040 M911_01045 M911_11120
EBS : ECTOBSL9_0035 ECTOBSL9_0896 ECTOBSL9_0897
TNI : TVNIR_3489(cobQ_[H])
GAI : IMCC3135_06025(cobQ)
BMV : BMASAVP1_A2316(cobQ)
BML : BMA10229_A2971(cobQ)
BPM : BURPS1710b_1200(cobQ)
BPL : BURPS1106A_1045(cobQ)
BUE : BRPE67_ACDS06000(cobQ)
PLG : NCTC10937_04023(cobQ)
LMIR : NCTC12852_02417(cobQ)
RAC : RA876_06645 RA876_06650
RHF : EUB48_03055 EUB48_08765
LIM : L103DPR2_02086(cobQ)
MPT : Mpe_A2304(copQ) Mpe_B0518(cobQ)
RGE : RGE_15080(cobQ) RGE_44400(cobQ) RGE_44410(cobQ)
RBN : RBXJA2T_12432 RBXJA2T_16392 RBXJA2T_16397
DOE : DENOEST_1202(cobQ) DENOEST_3183(cobQ)
AZA : AZKH_4148(cbiP_cobQ)
GSK : KN400_2935(cbiH_cbiP)
GME : Gmet_0485(cbiH_cbiP)
GEO : Geob_0038(cbiH_cbiP)
GBM : Gbem_3539(cbiH_cbiP)
GBN : GEOBRER4_34590(cbiH)
DES : DSOUD_0630(cbiH_cbiP)
DBK : DGMP_15220 DGMP_15230
RBS : RHODOSMS8_03449(cobQ)
SMEL : SM2011_c04309(cobQ)
SFD : USDA257_c42370(cobQ)
SAME : SAMCFNEI73_Ch2200(cobQ)
AGR : AGROH133_09261(cbiP)
REC : RHECIAT_CH0002598(cobQ)
REL : REMIM1_CH02518(cobQ)
REP : IE4803_CH02545(cobQ)
REI : IE4771_CH02632(cobQ)
RTR : RTCIAT899_CH10635(cobQ)
RGA : RGR602_CH02281(cobQ)
RPHA : AMC79_CH02625(cobQ)
NEN : NCHU2750_36400(cobQ)
BIO : BR141012304_11386(cobQ)
RPA : RPA0718(cobQ1) RPA2096(cobQ2)
RPX : Rpdx1_0770 Rpdx1_3418
MAQU : Maq22A_1p37770(cobQ)
MTUN : MTUNDRAET4_2068(cobQ)
HMC : HYPMC_0683(cobQ) HYPMC_2290(cobQ)
FIL : BN1229_v1_3180(cobQ)
FIY : BN1229_v1_2742(cobQ)
NTD : EGO55_10940 EGO55_18890
BLAG : BLTE_12850(cobQ_1) BLTE_24580(cobQ_2)
CCS : CCNA_01827(cobQ) CCNA_02776
BVY : NCTC9239_00637(cobQ)
RLI : RLO149_c013140(cobQ)
PHP : PhaeoP97_02272(cobQ)
PPIC : PhaeoP14_02188(cobQ)
RED : roselon_02145 roselon_02146 roselon_02152
SINL : DSM14862_02236(cobQ)
SPSE : SULPSESMR1_02111(cobQ)
RMM : ROSMUCSMR3_03954(cobQ)
AHT : ANTHELSMS3_02538(cobQ)
RSH : Rsph17029_2453 Rsph17029_3563 Rsph17029_3564
RSK : RSKD131_2158 RSKD131_4281 RSKD131_4282
CAZT : LV780_01710 LV780_20980 LV780_20985
RCP : RCAP_rcc02051(cobQ1) RCAP_rcc03354(cobQ2) RCAP_rcc03355(cobQ3)
RBL : B6K69_04460 B6K69_12305 B6K69_12310
RSU : NHU_00529(cobQ) NHU_02596(cobQ3) NHU_02597(cobQ2)
RHM : B5V46_10830 B5V46_10835 B5V46_15290
RHC : RGUI_0575 RGUI_1459 RGUI_1460
LVS : LOKVESSMR4R_02651(cobQ)
GEH : HYN69_05120 HYN69_19295
NOR : FA702_01495 FA702_20570
SBD : ATN00_04760 ATN00_12855
SPHT : K426_11000 K426_13535
SPPH : KFK14_02845 KFK14_09785
GXY : GLX_11350 GLX_12120 GLX_29590
KSC : CD178_01760(cobQ) CD178_03193(cobQ)
ATO : CIW82_17640 CIW82_18605
RRU : Rru_A3381 Rru_A3549 Rru_A3550
RRF : F11_17330 F11_18170 F11_18175
RPM : RSPPHO_00442 RSPPHO_00630(cobQ) RSPPHO_01816