The sequence of the cyo operon indicates substantial structural similarities between the cytochrome o ubiquinol oxidase of Escherichia coli and the aa3-type family of cytochrome c oxidases.
heme o synthase;
ctaB (gene name);
COX10 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
(2E,6E)-farnesyl-diphosphate:protoheme IX farnesyltranstransferase
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O = diphosphate + ferroheme o [RN:R07411]
The enzyme, found in many archaea, bacteria, and eukaryotes, produces heme o, which in many cases is further modified into heme a. In organisms that produce heme a, the enzyme forms a complex with heme a synthase. In some archaeal species the enzyme transfers a geranylgeranyl group instead of a farnesyl group.
