Entry Name coproporphyrinogen dehydrogenase;
Class Oxidoreductases;BRITE hierarchy
Sysname coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
Reaction(IUBMB) coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine [RN:
R06895 ]
Reaction(KEGG) Substrate coproporphyrinogen III [CPD:
C03263 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product Comment This enzyme differs from EC
1.3.3.3 , coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. It occurs mainly in bacteria, whereas eukaryotes use the oxygen-dependent oxidase. The reaction starts by using an electron from the reduced form of the enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the radical 5'-deoxyadenosin-5'-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion, ---(.)CH-CH2-COO- -> ---CH=CH2 + CO2 + e- replaces the electron initially used.
History EC 1.3.98.3 created 2004 as EC 1.3.99.22, transferred 2016 to EC 1.3.98.3
Pathway ec01110 Biosynthesis of secondary metabolites
Orthology K02495 oxygen-independent coproporphyrinogen III oxidase
Genes ECOO : ECRM13514_4939(hemN)
ECOH : ECRM13516_4719(hemN)
ECW : EcE24377A_4386(hemN)
ELN : NRG857_19280 NRG857_19320
EDJ : ECDH1ME8569_3738(hemN)
ELF : LF82_0984(hemN) LF82_604
ECOI : ECOPMV1_04229(hemN_3)
EFE : EFER_3610(hemN) EFER_3898
EMA : C1192_16130 C1192_16175(hemN)
STM : STM4004(hemN) STM4012
SEO : STM14_4815(hemN) STM14_4825
SEV : STMMW_39681 STMMW_39761
SEY : SL1344_3951(hemN) SL1344_3958
SEM : STMDT12_C41480 STMDT12_C41550
SEJ : STMUK_3987(hemN) STMUK_3995
SEB : STM474_4182(hemN) STM474_4189
SEF : UMN798_4342(hemN) UMN798_4349
SETU : STU288_20155 STU288_20190
SETC : CFSAN001921_20380 CFSAN001921_20415
SENR : STMDT2_38651(hemN) STMDT2_38721
SEND : DT104_40111(hemN) DT104_40191
SENI : CY43_20935 CY43_20970
SEEN : SE451236_00850 SE451236_00885
SPT : SPA3845(hemN) SPA3853
SEI : SPC_4107(hemN) SPC_4115
SEC : SCH_3896(hemN) SCH_3903(hemN)
SEW : SeSA_A4215(hemN) SeSA_A4222
SEA : SeAg_B4236(hemN) SeAg_B4243
SENS : Q786_19625 Q786_19660
SEL : SPUL_3660 SPUL_3667(hemN)
SEGA : SPUCDC_3646 SPUCDC_3654(hemN)
SET : SEN3792(hemN) SEN3799
SENA : AU38_19605 AU38_19640
SENO : AU37_19620 AU37_19655
SENV : AU39_19640 AU39_19675
SENQ : AU40_21915 AU40_21965
SENL : IY59_20100 IY59_20135
SENJ : CFSAN001992_13655 CFSAN001992_13695
SEEC : CFSAN002050_02895 CFSAN002050_02930
SEEB : SEEB0189_022295 SEEB0189_022330
SEEP : I137_17580 I137_17615
SENB : BN855_40700 BN855_40770(hemN)
SENE : IA1_19455 IA1_19490
SENC : SEET0819_03850 SEET0819_03885
SALZ : EOS98_22265 EOS98_22310(hemN)
ENR : H650_02860 H650_15340
KMI : VW41_00060 VW41_01590
RTG : NCTC13098_07159(hemN_3)
REE : electrica_05003(hemN_3)
CEM : LH23_05415 LH23_07570
CEN : LH86_05345 LH86_07460
CLAP : NCTC11466_04110(hemN_2) NCTC11466_04596(hemN_4)
KSA : C813_03475 C813_15225
KOT : EH164_06835 EH164_22110(hemN)
KPSE : IP581_00140(hemN) IP581_11255
KOB : HF650_16485 HF650_24005(hemN)
KIE : NCTC12125_03728(hemN_2)
BAGE : BADSM9389_41510(hemN)
AHN : NCTC12129_04965(hemN_3)
METY : MRY16398_56020(hemN)
PSHI : SAMEA2665130_2938(hemN_3)
YPG : YpAngola_A0026(hemN)
YPI : YpsIP31758_0024(hemN)
SMW : SMWW4_v1c24040 SMWW4_v1c48020(hemN)
SERF : L085_04290 L085_16650
SERS : SERRSCBI_11300 SERRSCBI_23290
SERA : Ser39006_002190(hemN)
SFJ : SAMEA4384070_4802(hemN_2)
SOF : NCTC11214_01681(hemN_2)
SURI : J0X03_00010(hemN) J0X03_12000
SNEM : NLX84_12195 NLX84_24685(hemN)
EAME : GXP68_05190 GXP68_21005(hemN)
PWA : Pecwa_1511 Pecwa_4514
PPAR : A8F97_11205 A8F97_18890
PWS : A7983_00800 A7983_07905
PAQU : DMB82_0020340(hemN)
DIC : Dpoa569_000026(hemN)
BIZ : HC231_03975 HC231_23270(hemN)
LBQ : CKQ53_00870 CKQ53_04920(hemN)
LPOP : I6N93_12915 I6N93_16685(hemN)
EGE : EM595_0028(hemN) EM595_p0049
PDIS : D8B20_16510 D8B20_17200(hemN)
PGZ : C2E15_01085 C2E15_21020(hemN)
MINT : C7M51_03439(hemN_2) C7M51_04358(hemN)
MTHI : C7M52_03610(hemN_2)
TPTY : NCTC11468_03843(hemN_2)
XPO : XPG1_0159(hemN) XPG1_2582
PRG : RB151_002850(hemN_1)
PHEI : NCTC12003_00291(hemN_2)
PRJ : NCTC6933_00309(hemN_2)
ANS : ArsFIN_36000(hemN_2)
LRI : NCTC12151_00038(hemN_1)
HPIT : NCTC13334_00364(hemN_2)
PDAG : 4362423_01985(hemN_2)
ADP : NCTC12871_01144(hemN_2)
ALIG : NCTC10568_00339(hemN_1)
ASEG : NCTC10977_00849(hemN)
AVT : NCTC3438_00041(hemN_1)
PAET : NCTC13378_00021(hemN)
XPH : XppCFBP6546_12870(XppCFBP6546P_12870)
SML : Smlt1690(hemN) Smlt2768
BUJ : BurJV3_1418 BurJV3_2286
SACZ : AOT14_14390(hemN_1) AOT14_33530(hemN_3)
STEK : AXG53_10450 AXG53_15490
STEN : CCR98_07580(hemN) CCR98_11860
STEM : CLM74_08090(hemN) CLM74_12180
STES : MG068_07255(hemN) MG068_11690
SINC : DAIF1_15190(hemN_1) DAIF1_23740(hemN_2)
PMEX : H4W19_03765(hemN) H4W19_11170(hemN)
LMB : C9I47_0662 C9I47_0898
LYJ : FKV23_05645(hemN) FKV23_15360
LSOL : GOY17_02975(hemN) GOY17_09540(hemN)
LLZ : LYB30171_00486(hemN)
LAUX : LA521A_05690(hemN) LA521A_17400(hemN)
THES : FHQ07_07115 FHQ07_13205(hemN)
DJI : CH75_00610 CH75_23690
VAU : VANGNB10_cI2644c(hemN)
VSR : Vspart_03277(hemN_2)
VPL : SA104470976_02620(hemN_2)
PAEB : NCGM1900_5034(hemN)
PCQ : PcP3B5_27660(hemN_2) PcP3B5_35940(hemN_3)
PMUI : G4G71_13335(hemN) G4G71_18915(hemN)
PNT : G5B91_19265(hemN) G5B91_20380(hemN)
PPUD : DW66_2224 DW66_4094
PMON : X969_07805 X969_17520
PVD : CFBP1590__1862(hemN)
PPRC : PFLCHA0_c19520(hemN)
PFE : PSF113_3001 PSF113_3002 PSF113_4016
PFN : HZ99_00930 HZ99_00935 HZ99_08345
PMAN : OU5_0476 OU5_0477 OU5_5437 OU5_P0225 OU5_P0226
PCG : AXG94_03900 AXG94_03905 AXG94_24540
PVR : PverR02_13230 PverR02_13235 PverR02_23230
PRX : HRH33_16100 HRH33_19900(hemN)
PMED : E3Z27_09130(hemN) E3Z27_16170(hemN)
PMUD : NCTC8068_01638(hemN_1) NCTC8068_02871(hemN_2) NCTC8068_02872(hemN_3)
PTOL : I7845_15765 I7845_21250(hemN)
PFW : PF1751_v1c40800(hemN)
PBA : PSEBR_a1718 PSEBR_a2639 PSEBR_a2640
PBC : CD58_09515 CD58_16230 CD58_16235
PPUU : PputUW4_03571(hemN1)
PDR : H681_06975 H681_15195
PSK : U771_13685 U771_13690 U771_23760
PCH : EY04_09190 EY04_17785
PCZ : PCL1606_26050 PCL1606_41250
PCP : JM49_13165 JM49_20655
PCHP : C4K32_2004 C4K32_3591
PALK : PSAKL28_21140 PSAKL28_21150 PSAKL28_36610
PFK : PFAS1_20790 PFAS1_27445 PFAS1_27450
PSIL : PMA3_07485 PMA3_16395 PMA3_16400
PVK : EPZ47_09330(hemN) EPZ47_16365(hemN) EPZ47_16370
PBZ : GN234_01970 GN234_01975(hemN) GN234_08955(hemN)
PKH : JLK41_10665(hemN) JLK41_12790(hemN) JLK41_14890(hemN) JLK41_14945
PDW : BV82_0988(hemN) BV82_3261(hemN) BV82_3262
PSEP : C4K39_2012 C4K39_2861
PVW : HU752_016810 HU752_023855(hemN)
PTRT : HU722_0021520(hemN)
PSHH : HU773_011725 HU773_011730(hemN) HU773_019815(hemN)
PASG : KSS96_17075 KSS96_21130(hemN)
PALV : KSS97_09870(hemN) KSS97_14320 KSS97_14325(hemN)
PTK : EXN22_09715(hemN) EXN22_12475 EXN22_12480(hemN)
PTW : TUM18999_37570(hemN)
PZA : HU749_010375(hemN) HU749_015290 HU749_015295(hemN)
PTAE : NCTC10697_01606(hemN1)
PPHN : HU825_13635 HU825_14295(hemN) HU825_15160(hemN)
