KEGG   ORTHOLOGY: K03334
Entry
K03334                      KO                                     
Symbol
IL4I1
Name
L-amino-acid oxidase [EC:1.4.3.2]
Pathway
map00250  Alanine, aspartate and glutamate metabolism
map00270  Cysteine and methionine metabolism
map00280  Valine, leucine and isoleucine degradation
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00380  Tryptophan metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00044  Tyrosine degradation, tyrosine => homogentisate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00270 Cysteine and methionine metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00280 Valine, leucine and isoleucine degradation
    K03334  IL4I1; L-amino-acid oxidase
   00350 Tyrosine metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00360 Phenylalanine metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00380 Tryptophan metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K03334  IL4I1; L-amino-acid oxidase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K03334  IL4I1; L-amino-acid oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.2  L-amino-acid oxidase
     K03334  IL4I1; L-amino-acid oxidase
Other DBs
RN: R00357 R00648 R00677 R00689 R00729 R02197
GO: 0001716
Genes
HSA: 259307(IL4I1)
PTR: 456223(IL4I1)
PPS: 100980850(IL4I1)
GGO: 101153847(IL4I1)
PON: 100936174(IL4I1)
NLE: 100588082(IL4I1)
MCC: 719114(IL4I1)
MCF: 102115096(IL4I1)
CSAB: 103225935 103235062(IL4I1)
CATY: 105595313(IL4I1)
PANU: 101019624(IL4I1) 110742566
TGE: 112612627(IL4I1)
RRO: 104667273(IL4I1)
RBB: 108535617 108535810(IL4I1)
TFN: 117091607(IL4I1)
PTEH: 111520078(IL4I1)
CJC: 100393511(IL4I1)
SBQ: 101036047(IL4I1)
CSYR: 103258095(IL4I1)
MMUR: 105865621(IL4I1)
OGA: 100942041(IL4I1)
MMU: 100328588(Il4i1b) 100470(Lao1) 14204(Il4i1) 73988(4930438A08Rik)
RNO: 100360621(Il4i1) 287305(RGD1308564) 298483(Lao1)
HGL: 101710424(Il4i1)
CPOC: 100722053(Il4i1) 100735244
OPI: 101528013(IL4I1) 101530470
TUP: 102481575 102484685(IL4I1)
CFA: 482436 484371(IL4I1)
VVP: 112908249 112931512(IL4I1)
VLG: 121478904(IL4I1) 121481065
AML: 100476680
UMR: 103657267(IL4I1) 103670918
UAH: 113243274(IL4I1) 113254224
UAR: 123776239(IL4I1) 123793625
MPUF: 101679701 101682166(IL4I1)
ORO: 101367095(IL4I1) 101374427
EJU: 114199615(IL4I1) 114224205
ZCA: 113914518 113935944(IL4I1)
MLX: 117998280(IL4I1) 118019531
FCA: 101100683(IL4I1) 111561629
PYU: 121017594 121018799(IL4I1)
PBG: 122479388 122493838(IL4I1)
PTG: 102958405(IL4I1) 107179172
PPAD: 109253035(IL4I1) 109254834
AJU: 106970164 106983121(IL4I1)
HHV: 120236036 120240706(IL4I1)
BTA: 104968452(IL4I1) 782545
BOM: 102265076(IL4I1) 102281829
BIU: 109556898 109572132(IL4I1)
BBUB: 102390358 102390534(IL4I1)
CHX: 102183203 102186899(IL4I1)
OAS: 101103614 105602079(IL4I1)
ODA: 120856603 120872106(IL4I1)
CCAD: 122420530(IL4I1) 122429212
BACU: 103000198(IL4I1) 103011548
LVE: 103085233 103091507(IL4I1)
OOR: 101272245 101278148(IL4I1)
DLE: 111175407 111180588(IL4I1)
PCAD: 102976825(IL4I1) 102988769
PSIU: 116744318(IL4I1) 116760484
MYD: 102756117
MMYO: 118655360(IL4I1) 118675115
MLF: 102417897 102425741(IL4I1)
MNA: 107531789(IL4I1) 107544363
PKL: 118712191(IL4I1) 118723116
HAI: 109391026(IL4I1)
DRO: 112310093(IL4I1)
SHON: 118977598(IL4I1)
AJM: 119050609(IL4I1) 119052159
PDIC: 114510932(IL4I1)
PHAS: 123830204(IL4I1) 123832082
MMF: 118638866(IL4I1)
RFQ: 117034479(IL4I1)
PALE: 102888858 102897392(IL4I1)
PGIG: 120607388 120615521(IL4I1)
PVP: 105301784(IL4I1) 105304057
RAY: 107500425(IL4I1) 107508277
MJV: 108383350(IL4I1)
TOD: 119236741 119249626(IL4I1)
SARA: 101543950(IL4I1)
OAA: 100079395(IL4I1)
GGA: 417039(IL4I1)
PCOC: 116236713(IL4I1)
MGP: 100540143(IL4I1)
CJO: 107321571(IL4I1)
NMEL: 110406676(IL4I1)
APLA: 101790142(IL4I1)
ACYG: 106049930(IL4I1)
AFUL: 116500228(IL4I1)
TGU: 100222394(IL4I1)
SCAN: 103824938(IL4I1)
PMOA: 120503973(IL4I1)
OTC: 121338701(IL4I1)
PRUF: 121359413(IL4I1)
GFR: 102037637(IL4I1)
FAB: 101808392(IL4I1)
PHI: 102109935(IL4I1)
PMAJ: 107198862(IL4I1)
CCAE: 111936793(IL4I1)
CCW: 120412144(IL4I1)
ZAB: 106630234(IL4I1)
FPG: 106112282(IL4I1)
FCH: 102046121(IL4I1)
CLV: 102086260(IL4I1)
EGZ: 104133949(IL4I1)
NNI: 104011855(IL4I1)
TALA: 104364431(IL4I1)
PADL: 103922928(IL4I1)
ACHC: 115337903(IL4I1)
AAM: 106482065(IL4I1)
AROW: 112978516(IL4I1)
DNE: 112992962(IL4I1)
AMJ: 102565465 102573609(IL4I1)
XLA: 108696562 108696644(il4i1.L)
XTR: 100493881(il4i1) 100496394
DRE: 337166(si:dkey-40g16.6)
IPU: 108277784(il4i1)
PHYP: 113532631(il4i1)
SMEO: 124394502(il4i1)
TFD: 113660452(il4i1)
EEE: 113579601(il4i1)
TRU: 101072153 101072660(il4i1)
NCC: 104942625
CGOB: 115017826(il4i1) 115024066
GAT: 120814801(il4i1) 120823029
PPUG: 119209117(il4i1) 119222932
NWH: 119429218(il4i1)
CSEM: 103377764(il4i1)
SSEN: 122766864 122773264(il4i1)
XGL: 120792272(il4i1) 120797257
HCQ: 109510681
BPEC: 110161951(il4i1)
MALB: 109954170(il4i1)
ELS: 105024042(il4i1)
SFM: 108928687(il4i1)
PKI: 111833916(il4i1)
AANG: 118209514(il4i1)
PSPA: 121303996(il4i1) 121324337
EAF: 111712914
BGT: 106053389
 » show all
Reference
PMID:9122225
  Authors
Chu CC, Paul WE
  Title
Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis.
  Journal
Proc Natl Acad Sci U S A 94:2507-12 (1997)
DOI:10.1073/pnas.94.6.2507
  Sequence
Reference
  Authors
Mason JM, Naidu MD, Barcia M, Porti D, Chavan SS, Chu CC
  Title
IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization.
  Journal
J Immunol 173:4561-7 (2004)
DOI:10.4049/jimmunol.173.7.4561
LinkDB

KEGG   ENZYME: 1.4.3.2
Entry
EC 1.4.3.2                  Enzyme                                 
Name
L-amino-acid oxidase;
ophio-amino-acid oxidase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
L-amino-acid:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 [RN:R01259]
Reaction(KEGG)
Substrate
L-amino acid [CPD:C00151];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
2-oxo carboxylate [CPD:C00161];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD).
History
EC 1.4.3.2 created 1961
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00270  Cysteine and methionine metabolism
ec00280  Valine, leucine and isoleucine degradation
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00380  Tryptophan metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K03334  L-amino-acid oxidase
Genes
HSA259307(IL4I1)
PTR456223(IL4I1)
PPS100980850(IL4I1)
GGO101153847(IL4I1)
PON100936174(IL4I1)
NLE100588082(IL4I1)
MCC719114(IL4I1)
MCF102115096(IL4I1)
CSAB103225935 103235062(IL4I1)
CATY105595313(IL4I1)
PANU101019624(IL4I1) 110742566
TGE112612627(IL4I1)
RRO104667273(IL4I1)
RBB108535617 108535810(IL4I1)
TFN117091607(IL4I1)
PTEH111520078(IL4I1)
CJC100393511(IL4I1)
SBQ101036047(IL4I1)
CSYR103258095(IL4I1)
MMUR105865621(IL4I1)
OGA100942041(IL4I1)
MMU100328588(Il4i1b) 100470(Lao1) 14204(Il4i1) 73988(4930438A08Rik)
MCAL110293665 110299207(Il4i1) 110304492
MPAH110323726 110324379(Il4i1) 110331259
RNO100360621(Il4i1) 287305(RGD1308564) 298483(Lao1)
MCOC116077959 116095759 116102147(Il4i1)
MUN110546799 110546802 110547447 110547449 110547463 110552192
CGE100753207 100773063(Il4i1) 118237661
PLEU114684326(Il4i1) 114686459 114704946
NGI103728550 103743345 103743685(Il4i1)
HGL101710424(Il4i1)
CPOC100722053(Il4i1) 100735244
CCAN109678621 109683916(Il4i1) 109685329
DORD105985117 105985269 105986039 105994157(Il4i1)
DSP122103786 122103787 122103789 122103841 122125580(Il4i1)
NCAR124964052 124967124 124986519
OCU100353438 100355677 103347204(IL4I1)
OPI101528013(IL4I1) 101530470
TUP102481575 102484685(IL4I1)
CFA482436 484371(IL4I1)
VVP112908249 112931512(IL4I1)
VLG121478904(IL4I1) 121481065
AML100476680
UMR103657267(IL4I1) 103670918
UAH113243274(IL4I1) 113254224
UAR123776239(IL4I1) 123793625
ELK111142798 111160542
LLV125089747 125098760
MPUF101679701 101682166(IL4I1)
ORO101367095(IL4I1) 101374427
EJU114199615(IL4I1) 114224205
ZCA113914518 113935944(IL4I1)
MLX117998280(IL4I1) 118019531
FCA101100683(IL4I1) 111561629
PYU121017594 121018799(IL4I1)
PBG122479388 122493838(IL4I1)
PTG102958405(IL4I1) 107179172
PPAD109253035(IL4I1) 109254834
AJU106970164 106983121(IL4I1)
HHV120236036 120240706(IL4I1)
BTA104968452(IL4I1) 782545
BOM102265076(IL4I1) 102281829
BIU109556898 109572132(IL4I1)
BBUB102390358 102390534(IL4I1)
CHX102183203 102186899(IL4I1)
OAS101103614 105602079(IL4I1)
ODA120856603 120872106(IL4I1)
CCAD122420530(IL4I1) 122429212
SSC100522257(IL4I1) 100524382 100525099
CFR102508990 102515461(IL4I1) 102517966
CBAI105062771(IL4I1) 105064484 105072853
CDK105090941 105094151 105100234(IL4I1)
VPC102525051(IL4I1) 102531830 116279810
BACU103000198(IL4I1) 103011548
LVE103085233 103091507(IL4I1)
OOR101272245 101278148(IL4I1)
DLE111175407 111180588(IL4I1)
PCAD102976825(IL4I1) 102988769
PSIU116744318(IL4I1) 116760484
ECB100055246 100147151 100147304(IL4I1)
EPZ103558296(IL4I1) 103563233 103567078
EAI106840130 106847809 123281322(IL4I1)
MYB102244387 102250318
MYD102756117
MMYO118655360(IL4I1) 118675115
MLF102417897 102425741(IL4I1)
MNA107531789(IL4I1) 107544363
PKL118712191(IL4I1) 118723116
HAI109391026(IL4I1)
DRO112310093(IL4I1)
SHON118977598(IL4I1)
AJM119050609(IL4I1) 119052159
PDIC114510932(IL4I1)
PHAS123830204(IL4I1) 123832082
MMF118638866(IL4I1)
RFQ117034479(IL4I1)
PALE102888858 102897392(IL4I1)
PGIG120607388 120615521(IL4I1)
PVP105301784(IL4I1) 105304057
RAY107500425(IL4I1) 107508277
MJV108383350(IL4I1)
TOD119236741 119249626(IL4I1)
SARA101543950(IL4I1)
LAV100657023 100665294(IL4I1) 100677374
TMU101342469 101351869 101357695
DNM101416894 101417025 101424791 101425232 101425498 101435175 101435655 101445014 101445089 111760677
MDO100010068 100032718 103099142(IL4I1)
GAS123238857 123247310
SHR100917854 100918118 100923259 100932442
PCW110194214 110205983 110219789(IL4I1)
OAA100079395(IL4I1)
GGA417039(IL4I1)
PCOC116236713(IL4I1)
MGP100540143(IL4I1)
CJO107321571(IL4I1)
NMEL110406676(IL4I1)
APLA101790142(IL4I1)
ACYG106049930(IL4I1)
AFUL116500228(IL4I1)
TGU100222394(IL4I1)
SCAN103824938(IL4I1)
PMOA120503973(IL4I1)
OTC121338701(IL4I1)
PRUF121359413(IL4I1)
GFR102037637(IL4I1)
FAB101808392(IL4I1)
PHI102109935(IL4I1)
PMAJ107198862(IL4I1)
CCAE111936793(IL4I1)
CCW120412144(IL4I1)
ZAB106630234(IL4I1)
FPG106112282(IL4I1)
FCH102046121(IL4I1)
CLV102086260(IL4I1)
EGZ104133949(IL4I1)
NNI104011855(IL4I1)
TALA104364431(IL4I1)
PADL103922928(IL4I1)
ACHC115337903(IL4I1)
AAM106482065(IL4I1)
AROW112978516(IL4I1)
DNE112992962(IL4I1)
ASN102368180 102384151 102384392
AMJ102565465 102573609(IL4I1)
PSS102454164 102456958 102457207 102457453 102458451 102461938
CMY102942718 102945232 102945460 102945689 102945918 102947871
CPIC101935439 101941085 101942263 101942815 101943090 101944444
TST117887160 117887178 117887179 117887181 117887215
CABI116819430 116820392 116820393 116820394
MRV120383048 120383050 120383102 120383683 120392389 120394231
ACS100563852 100566795 100566990 100567189
PVT110071372 110088018 110088019 110088021 110088022
SUND121918314 121920299 121920300 121920301 121920302 121920303
PBI103050915 103053826 103058185
PMUR107289616 107289625 107289632 107292853
TSR106539221 106544367 106555017
PGUT117668040 117668047
VKO123034405 123034410 123034411 123034607
PMUA114588443 114588610 114588621 114590937
ZVI118080102 118080932 118080933
GJA107124516 107124520
XLA108696562 108696644(il4i1.L)
XTR100493881(il4i1) 100496394
NPR108791768 108791770 108791771
RTEM120915363 120915364 120915365 120915366
BBUF120997974 120997986
BGAR122928754 122928755
DRE337166(si:dkey-40g16.6)
SRX107709125 107717264
SANH107657246 107670951
SGH107586302 107601700
CCAR109058498 109064604 109103696
CAUA113058421 113115537
IPU108277784(il4i1)
PHYP113532631(il4i1)
SMEO124394502(il4i1)
TFD113660452(il4i1)
AMEX103030662 103030984 103034230
EEE113579601(il4i1)
TRU101072153 101072660(il4i1)
TNGGSTEN00004026G001 GSTEN00026846G001
LCO104937478 104937491 104940603(il4i1)
NCC104942625
CGOB115017826(il4i1) 115024066
ELY117246507 117246508 117252548 117260093(il4i1)
PLEP121943552(il4i1) 121944726 121962097 121962098 121962508 121962509
SLUC116038885(il4i1) 116052105 116052106 116052108 116052109 116052146
ECRA117942447(il4i1) 117962121 117962122
PFLV114545909 114545953 114546186 114546189 114546190 114546191 114552578(il4i1)
GAT120814801(il4i1) 120823029
PPUG119209117(il4i1) 119222932
MSAM119882627(il4i1) 119896366 119912615 119912745 119918947 119918948
CUD121504363 121504400 121504402 121504874 121505065 121505066 121527143(il4i1)
MZE101470741 101473683 101473989 112431521 112431528
ONL100695605 100697201 100703044 100703315 100707943
OAU116311629 116311630 116312996(il4i1) 116313896 116331917 116333564
OLA101160780 101161073 101163441 101171229 105356325
OML112149798(il4i1) 112155644 112155698 112156072 112156354 112156355
XMA102218509 102227815 102228075 106700049
XCO114149637 114156799 114156839 114157965
XHE116708192 116732114 116732163 116732189
PRET103461196 103474367 103480925 103480937 103480938
PFOR103149034 103149035 103149095 103149096 103156786 103156791
PLAI106935008 106947289 106947294 106947295
PMEI106908903 106911400 106926808 106926809 106926813 106926815
GAF122820715 122820716 122820989 122820990 122833314(il4i1)
CVG107082273 107099630 107099631 107099633 107099634 107099636 107103271
CTUL119777187 119777189 119777195 119791854(il4i1)
GMU124880954 124881157 124881159 124881160 124881161 124881168 124883694(il4i1)
NFU107374444 107374445 107380798(il4i1)
KMR108247696(il4i1) 108248303 108248304
ALIM106522793 106525020 106525021 106535079
NWH119429218(il4i1)
AOCE111571215 111571474 111585375 111585379
CSEM103377764(il4i1)
POV109639351 109644254
SSEN122766864 122773264(il4i1)
HHIP117752108 117752109 117752194 117772864(il4i1)
LCF108900578 108902378 108902379
SDU111234776(il4i1) 111236665 111236666
SLAL111652095 111652096 111671319(il4i1)
XGL120792272(il4i1) 120797257
HCQ109510681
BPEC110161951(il4i1)
MALB109954170(il4i1)
SASA106561133 106580948 106612549
OTW112265402 112266925
OMY110492681 110503766(il4i1) 110507168
OGO123993959 124004792
ONE115134799 115141709
SALP111949891 111959920 111962163
SNH120018275 120029032(il4i1) 120066129
ELS105024042(il4i1)
SFM108928687(il4i1)
PKI111833916(il4i1)
AANG118209514(il4i1)
LOC102691176 102696231 102698727
PSPA121303996(il4i1) 121324337
ARUT117397171 117397368 117422133 117422222
LCM102345877 102355982 102367420
EAF111712914
BGT106053389
HRF124110692 124110693 124110715 124110716 124110823 124110824 124113997 124113999 124114004 124116185 124132876 124149366 124151981 124152001
HRJ124262556 124276867 124281648 124288113 124288116 124291771 124291796
CRG105329637 105336823
PMAX117321607 117340737
MMER123527946 123528636 123528720 123528850 123528870 123528990 123529239 123529452 123530170 123530240 123530241 123536688 123540459 123543766 123550737 123551352 123551752 123551772 123553585 123553597 123553611 123563332 123563337
XEN124439720 124445263 124454201 124454202 124454222 124454225 124454575 124454577 124454760 124455753 124456649
 » show all
Reference
1
  Authors
Meister, A. and Wellner, D.
  Title
Flavoprotein amino acid oxidase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 609-648.
Reference
2  [PMID:13843884]
  Authors
WELLNER D, MEISTER A.
  Title
Crystalline L-amino acid oxidase of Crotalus adamanteus.
  Journal
J Biol Chem 235:2013-8 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.2
IUBMB Enzyme Nomenclature: 1.4.3.2
ExPASy - ENZYME nomenclature database: 1.4.3.2
BRENDA, the Enzyme Database: 1.4.3.2
CAS: 9000-89-9
LinkDB

KEGG   REACTION: R00729
Entry
R00729                      Reaction                               
Name
L-Tyrosine:oxygen oxidoreductase (deaminating)
Definition
L-Tyrosine + H2O + Oxygen <=> 3-(4-Hydroxyphenyl)pyruvate + Ammonia + Hydrogen peroxide
Equation
Reaction class
RC00006  C00082_C01179
RC02755  C00007_C00027
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00044  Tyrosine degradation, tyrosine => homogentisate
Orthology
K03334  L-amino-acid oxidase [EC:1.4.3.2]
Other DBs
RHEA: 61251
LinkDB

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