Entry |
|
Name |
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2
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Class |
Transferases;
Glycosyltransferases;
Sialyltransferases
|
Sysname |
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase
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Reaction(IUBMB) |
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN: R04564]
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Reaction(KEGG) |
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Substrate |
CMP-N-acetylneuraminate [CPD: C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
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Product |
CMP [CPD: C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
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Comment |
Gangliosides act as acceptors.
|
History |
EC 2.4.3.8 created 1984 as EC 2.4.99.8, modified 1986, transferred 2022 to EC 2.4.3.8
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Pathway |
ec00601 | Glycosphingolipid biosynthesis - lacto and neolacto series |
ec00603 | Glycosphingolipid biosynthesis - globo and isoglobo series |
ec00604 | Glycosphingolipid biosynthesis - ganglio series |
|
Orthology |
K03371 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) |
|
Genes |
ECB: | 100064415(ST8SIA1) 111772030 111772221 111772374 |
PBRV: | 138175778 138176100 |
XLA: | 108712513(st8sia1.S) 398735(st8sia1.L) |
CCAR: | 109045336 109066147 |
CAUA: | 113048254 113061141 |
CGIB: | 127956856 127972491 |
MASI: | 127435346 127436847 |
IPU: | 108279455(st8sia1) 108279490 |
IFU: | 128623476(st8sia1) 128623558 |
CHAR: | 105889648(st8sia1) 105892368 105892371 105892372 105909703 116219229 |
PLAI: | 106961373 106961377 |
SASA: | 106595526 106609639(st8sia1) |
STRU: | 115180086 115199122 |
CCLU: | 121543396 121549897 |
AANG: | 118219081(st8sia1) 118231201 |
PSPA: | 121318379 121319722 |
ARUT: | 117414707 117419486 |
LPIC: | 129272954 129272955 |
» show all
|
Reference |
|
Authors |
Eppler CM, Morre DJ, Keenan TW. |
Title |
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides. |
Journal |
|
Reference |
|
Authors |
Higashi H, Basu M, Basu S. |
Title |
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain. |
Journal |
J Biol Chem 260:824-8 (1985) |
Reference |
|
Authors |
McCoy RD, Vimr ER, Troy FA. |
Title |
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules. |
Journal |
J Biol Chem 260:12695-9 (1985) |
Reference |
|
Authors |
Yohe HC, Yu RK. |
Title |
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a. |
Journal |
J Biol Chem 255:608-13 (1980) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.4.3.8 |
ExPASy - ENZYME nomenclature database: | 2.4.3.8 |
BRENDA, the Enzyme Database: | 2.4.3.8 |
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LinkDB |
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