KEGG   ORTHOLOGY: K03371
Entry
K03371                      KO                                     
Symbol
ST8SIA1
Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) [EC:2.4.3.8]
Pathway
map00601  Glycosphingolipid biosynthesis - lacto and neolacto series
map00603  Glycosphingolipid biosynthesis - globo and isoglobo series
map00604  Glycosphingolipid biosynthesis - ganglio series
map01100  Metabolic pathways
Module
M00069  Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3
Reaction
R05940  
R05947  
R06032  
R13175  alpha-2,8-sialyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K03371  ST8SIA1; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K03371  ST8SIA1; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
   00604 Glycosphingolipid biosynthesis - ganglio series
    K03371  ST8SIA1; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K03371  ST8SIA1; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.3  Sialyltransferases
    2.4.3.8  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
     K03371  ST8SIA1; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Glycosyltransferases [BR:ko01003]
 Terminal extension
  Sialyltransferase
   K03371  ST8SIA1; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Other DBs
GO: 0003828
CAZy: GT29
Genes
HSA: 6489(ST8SIA1)
PTR: 465341(ST8SIA1)
PPS: 100970748(ST8SIA1)
GGO: 101134419(ST8SIA1)
PON: 100455082(ST8SIA1)
PPYG: 129010874(ST8SIA1)
NLE: 100588840(ST8SIA1)
HMH: 116472771(ST8SIA1)
SSYN: 129483261(ST8SIA1)
MCC: 706707(ST8SIA1)
MCF: 102118571(ST8SIA1)
MTHB: 126930525
MNI: 105492107(ST8SIA1)
CSAB: 103218743(ST8SIA1)
CATY: 105585055(ST8SIA1)
PANU: 101010038(ST8SIA1)
TGE: 112635598(ST8SIA1)
MLEU: 105535615
RRO: 104660754(ST8SIA1)
RBB: 108541110(ST8SIA1)
TFN: 117090396(ST8SIA1)
PTEH: 111540637(ST8SIA1)
CANG: 105521116(ST8SIA1)
CJC: 118144189(ST8SIA1)
SBQ: 101042881(ST8SIA1)
CIMI: 108300261(ST8SIA1)
ANAN: 105720548(ST8SIA1)
MMUR: 105882799(ST8SIA1)
LCAT: 123639934(ST8SIA1)
PCOQ: 105807576(ST8SIA1)
OGA: 100950426(ST8SIA1)
MMU: 20449(St8sia1)
MCAL: 110296666(St8sia1)
MPAH: 110316454(St8sia1)
RNO: 25280(St8sia1)
MCOC: 116099770(St8sia1)
ANU: 117714671(St8sia1)
MUN: 110560539(St8sia1)
CGE: 100768920(St8sia1)
MAUA: 101833067(St8sia1)
PROB: 127213126(St8sia1)
PLEU: 114700282(St8sia1)
MORG: 121437731(St8sia1)
MFOT: 126497325
AAMP: 119808271(St8sia1)
NGI: 103736726(St8sia1)
HGL: 101696963(St8sia1)
CPOC: 100715414(St8sia1)
CCAN: 109700114(St8sia1)
DORD: 105992241(St8sia1)
DSP: 122102811
PLOP: 125342728(St8sia1)
NCAR: 124983767
MMMA: 107152803(St8sia1)
OCU: 100351155
OPI: 101532071(ST8SIA1)
TUP: 102468919(ST8SIA1)
GVR: 103599358(ST8SIA1)
CFA: 477672(ST8SIA1)
CLUD: 112665513(ST8SIA1)
VVP: 112917220(ST8SIA1)
VLG: 121480215(ST8SIA1)
NPO: 129505598(ST8SIA1)
AML: 100464397(ST8SIA1)
UMR: 103665233(ST8SIA1)
UAH: 113257801(ST8SIA1)
UAR: 123801659(ST8SIA1)
ELK: 111159987
LLV: 125107481
MPUF: 101693103(ST8SIA1)
MNP: 132019570(ST8SIA1)
MLK: 131838912(ST8SIA1)
NVS: 122891780(ST8SIA1)
ORO: 101366887(ST8SIA1)
EJU: 114216633(ST8SIA1)
ZCA: 113922906(ST8SIA1)
MLX: 118025582(ST8SIA1)
NSU: 110581009(ST8SIA1)
LWW: 102733721(ST8SIA1)
FCA: 101093029(ST8SIA1)
PYU: 121038820(ST8SIA1)
PCOO: 112867675(ST8SIA1)
PBG: 122473547(ST8SIA1)
PVIV: 125171212(ST8SIA1)
LRUF: 124502469
PTG: 102962819(ST8SIA1)
PPAD: 109268731(ST8SIA1)
PUC: 125918896
AJU: 106967976
HHV: 120236008(ST8SIA1)
BTA: 282352(ST8SIA1)
BOM: 102273511(ST8SIA1)
BIU: 109559591(ST8SIA1)
BBUB: 102401968(ST8SIA1)
BBIS: 105000216(ST8SIA1)
CHX: 102187381(ST8SIA1)
OAS: 101117321(ST8SIA1)
BTAX: 128048547(ST8SIA1)
CSUM: 138079194(ST8SIA1)
ODA: 120858934(ST8SIA1)
CCAD: 122423333(ST8SIA1)
MREE: 136171647(ST8SIA1)
MBEZ: 129535648(ST8SIA1)
SSC: 100625270(ST8SIA1)
CFR: 102512853(ST8SIA1)
CBAI: 105062287(ST8SIA1)
CDK: 105096526(ST8SIA1)
VPC: 102526499(ST8SIA1)
BACU: 103009301(ST8SIA1)
BMUS: 118902638(ST8SIA1)
LVE: 103076775(ST8SIA1)
OOR: 101285691(ST8SIA1)
DLE: 111176840(ST8SIA1)
PCAD: 102987127(ST8SIA1)
PSIU: 116760632(ST8SIA1)
NASI: 112391788(ST8SIA1)
EPZ: 103554941(ST8SIA1)
EAI: 106825576(ST8SIA1)
MYB: 102249041(ST8SIA1)
MYD: 102769678
MMYO: 118650342(ST8SIA1)
MLF: 102436879(ST8SIA1)
MDT: 132227371(ST8SIA1)
PKL: 118730430(ST8SIA1)
EFUS: 103285148(ST8SIA1)
MNA: 107525320(ST8SIA1)
DRO: 112318440(ST8SIA1)
SHON: 118978440(ST8SIA1)
AJM: 119048980(ST8SIA1)
PDIC: 114513284(ST8SIA1)
PHAS: 123812877(ST8SIA1)
MMF: 118624046(ST8SIA1)
PPAM: 129084976(ST8SIA1)
HAI: 109375156(ST8SIA1)
RFQ: 117028889(ST8SIA1)
PALE: 102892181(ST8SIA1)
PGIG: 120618362(ST8SIA1)
PVP: 105306530(ST8SIA1)
RAY: 107508581(ST8SIA1)
MJV: 108398355(ST8SIA1)
TOD: 119247638(ST8SIA1)
SARA: 101536942(ST8SIA1)
SETR: 126022805(ST8SIA1)
LAV: 100659787(ST8SIA1)
TMU: 101359255
ETF: 101651002(ST8SIA1)
DNM: 101439062(ST8SIA1)
MDO: 100011205(ST8SIA1)
GAS: 123250017(ST8SIA1)
SHR: 100920916(ST8SIA1)
AFZ: 127539289
PCW: 110213804(ST8SIA1)
TVP: 118851960(ST8SIA1)
OAA: 100080234(ST8SIA1)
GGA: 395860(ST8SIA1)
PCOC: 116231405(ST8SIA1)
MGP: 100547921(ST8SIA1)
CJO: 107317147(ST8SIA1)
TPAI: 128084524(ST8SIA1)
LMUT: 125697894(ST8SIA1)
NMEL: 110396210(ST8SIA1)
APLA: 101797310(ST8SIA1)
ACYG: 106038258(ST8SIA1)
CATA: 118245122(ST8SIA1)
AFUL: 116502321(ST8SIA1)
TGU: 100225976(ST8SIA1)
LSR: 110470391(ST8SIA1)
SCAN: 103820535(ST8SIA1)
PMOA: 120497130(ST8SIA1)
OTC: 121332784(ST8SIA1)
PRUF: 121362718(ST8SIA1)
GFR: 102037290(ST8SIA1)
FAB: 101806998(ST8SIA1)
OMA: 130267021(ST8SIA1)
PHI: 102111773(ST8SIA1)
PMAJ: 107204564(ST8SIA1)
CCAE: 111923319(ST8SIA1)
CCW: 104692305(ST8SIA1)
CBRC: 103617289(ST8SIA1)
ETL: 114069418(ST8SIA1)
ZAB: 102064143(ST8SIA1)
ZLE: 135458792(ST8SIA1)
ACHL: 103800160(ST8SIA1)
SVG: 106855510(ST8SIA1)
MMEA: 130575566(ST8SIA1)
HRT: 120751890(ST8SIA1)
SATI: 136361524(ST8SIA1)
FPG: 101922614(ST8SIA1)
FCH: 102056471(ST8SIA1)
CCRI: 104168338(ST8SIA1)
NNT: 104403606(ST8SIA1)
SHAB: 115605291(ST8SIA1)
ACUN: 113487646(ST8SIA1)
TALA: 104365612(ST8SIA1)
ACHC: 115352512(ST8SIA1)
AGEN: 126047785
GCL: 127019811
CSTI: 104564133(ST8SIA1)
LDI: 104347216(ST8SIA1)
DPUB: 104299482(ST8SIA1)
PPUS: 135182124(ST8SIA1)
BRHI: 104489776
EGZ: 104135090(ST8SIA1)
NNI: 104012705(ST8SIA1)
PCRI: 104034257
PCAO: 104043589(ST8SIA1)
PADL: 103924330(ST8SIA1)
AFOR: 103898734(ST8SIA1)
CLV: 102093502(ST8SIA1)
PGUU: 104466166
CMAC: 104479213
CUCA: 104059493(ST8SIA1)
TEO: 104372828(ST8SIA1)
OHA: 104327191(ST8SIA1)
ACAR: 104521623(ST8SIA1)
CPEA: 104393457(ST8SIA1)
CVF: 104281725(ST8SIA1)
RTD: 128910513(ST8SIA1)
AAM: 106488295(ST8SIA1)
AROW: 112966614(ST8SIA1)
NPD: 112944369(ST8SIA1)
TGT: 104578998(ST8SIA1)
DNE: 112978905(ST8SIA1)
SCAM: 104154118(ST8SIA1)
ASN: 102378302(ST8SIA1)
AMJ: 102562267(ST8SIA1)
CPOO: 109316395(ST8SIA1)
GGN: 109296296(ST8SIA1)
PSS: 102462829(ST8SIA1)
CMY: 102943965(ST8SIA1)
CCAY: 125625048(ST8SIA1)
DCC: 119850214(ST8SIA1)
CPIC: 101937464(ST8SIA1)
TST: 117883367(ST8SIA1)
CABI: 116835477(ST8SIA1)
MRV: 120371084(ST8SIA1)
ACS: 100337536(st8sia1)
ASAO: 132775711(ST8SIA1)
PVT: 110091198(ST8SIA1)
SUND: 121930321(ST8SIA1)
PBI: 103065178(ST8SIA1)
PMUR: 107295788(ST8SIA1)
CTIG: 120309794(ST8SIA1)
TSR: 106547779(ST8SIA1)
PGUT: 117679860(ST8SIA1)
APRI: 131202524(ST8SIA1)
PTEX: 113437871(ST8SIA1)
NSS: 113419064(ST8SIA1)
VKO: 123034657(ST8SIA1)
PMUA: 114605143(ST8SIA1)
PRAF: 128422080(ST8SIA1)
ZVI: 118091196(ST8SIA1)
HCG: 128327158(ST8SIA1)
GJA: 107105667
STOW: 125434326(ST8SIA1)
EMC: 129336057(ST8SIA1)
XLA: 108712513(st8sia1.S) 398735(st8sia1.L)
XTR: 444887(st8sia1)
NPR: 108789879(ST8SIA1)
RTEM: 120932763(ST8SIA1)
BBUF: 121005110(ST8SIA1)
BGAR: 122926561(ST8SIA1)
DRE: 553210(st8sia1)
SANH: 107689712(st8sia1)
SGH: 107567669
PTET: 122342725(st8sia1)
LROH: 127164321(st8sia1)
OMC: 131539055(st8sia1)
PPRM: 120477091(st8sia1)
RKG: 130092533(st8sia1)
MAMB: 125245379(st8sia1)
CIDE: 127511328
CERY: 137023976(st8sia1)
TROS: 130547566(st8sia1)
TDW: 130420284(st8sia1)
MANU: 129432559(st8sia1)
IPU: 108279455(st8sia1) 108279490
IFU: 128623476(st8sia1) 128623558
PHYP: 113531749(st8sia1)
SMEO: 124401145(st8sia1)
TFD: 113647226(st8sia1)
TVC: 132859374(st8sia1)
TRN: 134324994(st8sia1)
AMEX: 103035159(st8sia1)
CMAO: 118812360(st8sia1)
EEE: 113584008(st8sia1)
TRU: 445978(st8sia1)
TFS: 130519207(st8sia1)
LCO: 109141779(st8sia1)
NCC: 104958359(st8sia1)
TBEN: 117485063(st8sia1)
CGOB: 115028360(st8sia1)
PGEO: 117439298(st8sia1)
GACU: 117547931(st8sia1)
EMAC: 134879382(st8sia1)
ELY: 117249341(st8sia1)
EFO: 125882523(st8sia1)
PLEP: 121961498(st8sia1)
SLUC: 116060120(st8sia1)
ECRA: 117938764(st8sia1)
ESP: 116673185(st8sia1)
PFLV: 114550187(st8sia1)
GAT: 100174872
PPUG: 119211090(st8sia1)
AFB: 129112618(st8sia1)
CLUM: 117726120(st8sia1)
PSWI: 130200293(st8sia1)
CANA: 137791408(st8sia1)
CVE: 137880146(st8sia1)
MSAM: 119918439(st8sia1)
SCHU: 122871344(st8sia1)
CUD: 121505444(st8sia1)
ALAT: 119032673(st8sia1)
ASTR: 137589233(st8sia1)
MZE: 101480363(st8sia1)
ONL: 100695121(st8sia1)
OAU: 116309833(st8sia1)
OLA: 100049518(st8sia1)
OML: 112155472(st8sia1)
CSAI: 133423960(st8sia1)
XMA: 102218717(st8sia1)
XCO: 114141471(st8sia1)
XHE: 116736502(st8sia1)
PRET: 103459243(st8sia1)
PFOR: 103146226(st8sia1)
PMEI: 106931844(st8sia1)
GAF: 122826653(st8sia1)
PPRL: 129375504(st8sia1)
CVG: 107085992(st8sia1)
CTUL: 119785664(st8sia1)
GMU: 124883158(st8sia1)
NFU: 107379800(st8sia1)
KMR: 108235108(st8sia1)
ALIM: 106533543(st8sia1)
NWH: 119428390(st8sia1)
AOCE: 111571510(st8sia1)
EJA: 138207524(st8sia1)
MCEP: 125000032(st8sia1)
CSEM: 103382754(st8sia1)
POV: 109632888(st8sia1)
SSEN: 122767240(st8sia1)
HHIP: 117756967(st8sia1)
HSP: 118101632(st8sia1)
PPLT: 128428642
SMAU: 118287693(st8sia1)
LCF: 108879661
SDU: 111224971(st8sia1)
SLAL: 111671912(st8sia1)
XGL: 120802191(st8sia1)
HCQ: 109523778(st8sia1)
SSCV: 125992241(st8sia1)
SBIA: 133493589(st8sia1)
PEE: 133396986(st8sia1)
PTAO: 133471915(st8sia1)
BPEC: 110170325(st8sia1)
MALB: 109959852(st8sia1)
BSPL: 114862095(st8sia1)
SJO: 128353385(st8sia1)
SASA: 106595526 106609639(st8sia1)
OTW: 112242451(st8sia1)
OGO: 124026144(st8sia1)
ONE: 115114980
OKI: 109879214(st8sia1)
OKE: 118372698(st8sia1)
ELS: 105020361(st8sia1)
AANG: 118219081(st8sia1) 118231201
LOC: 102694617(st8sia1)
PSEX: 120534204(st8sia1)
LCM: 102350065(ST8SIA1)
CMK: 103181078(st8sia1)
RTP: 109917984(st8sia1)
CPLA: 122561586(st8sia1)
HOC: 132826941(st8sia1)
LERI: 129707670
PMRN: 103091726(ST8SIA1)
LRJ: 133351486(ST8SIA1)
ARUN: 117302666
 » show all
Reference
PMID:8058740
  Authors
Nara K, Watanabe Y, Maruyama K, Kasahara K, Nagai Y, Sanai Y
  Title
Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells.
  Journal
Proc Natl Acad Sci U S A 91:7952-6 (1994)
DOI:10.1073/pnas.91.17.7952
  Sequence
[hsa:6489]
LinkDB

KEGG   ENZYME: 2.4.3.8
Entry
EC 2.4.3.8                  Enzyme                                 
Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2
Class
Transferases;
Glycosyltransferases;
Sialyltransferases
Sysname
CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN:R04564]
Reaction(KEGG)
R04564 > R04583 R05940(G) R05947(G) R06032(G) R13175(G);
(other) R04632 R04649 R04661 R05113 R05995(G) R06000(G) R06005(G) R06009(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
Comment
Gangliosides act as acceptors.
History
EC 2.4.3.8 created 1984 as EC 2.4.99.8, modified 1986, transferred 2022 to EC 2.4.3.8
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03371  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)
Genes
HSA6489(ST8SIA1)
PTR465341(ST8SIA1)
PPS100970748(ST8SIA1)
GGO101134419(ST8SIA1)
PON100455082(ST8SIA1)
PPYG129010874(ST8SIA1)
NLE100588840(ST8SIA1)
HMH116472771(ST8SIA1)
SSYN129483261(ST8SIA1)
MCC706707(ST8SIA1)
MCF102118571(ST8SIA1)
MTHB126930525
MNI105492107(ST8SIA1)
CSAB103218743(ST8SIA1)
CATY105585055(ST8SIA1)
PANU101010038(ST8SIA1)
TGE112635598(ST8SIA1)
MLEU105535615
RRO104660754(ST8SIA1)
RBB108541110(ST8SIA1)
TFN117090396(ST8SIA1)
PTEH111540637(ST8SIA1)
CANG105521116(ST8SIA1)
CJC118144189(ST8SIA1)
SBQ101042881(ST8SIA1)
CIMI108300261(ST8SIA1)
ANAN105720548(ST8SIA1)
MMUR105882799(ST8SIA1)
LCAT123639934(ST8SIA1)
PCOQ105807576(ST8SIA1)
OGA100950426(ST8SIA1)
MMU20449(St8sia1)
MCAL110296666(St8sia1)
MPAH110316454(St8sia1)
RNO25280(St8sia1)
MCOC116099770(St8sia1)
ANU117714671(St8sia1)
MUN110560539(St8sia1)
CGE100768920(St8sia1)
MAUA101833067(St8sia1)
PROB127213126(St8sia1)
PLEU114700282(St8sia1)
MORG121437731(St8sia1)
MFOT126497325
AAMP119808271(St8sia1)
NGI103736726(St8sia1)
HGL101696963(St8sia1)
CPOC100715414(St8sia1)
CCAN109700114(St8sia1)
DORD105992241(St8sia1)
DSP122102811
PLOP125342728(St8sia1)
NCAR124983767
MMMA107152803(St8sia1)
OCU100351155
OPI101532071(ST8SIA1)
TUP102468919(ST8SIA1)
GVR103599358(ST8SIA1)
CFA477672(ST8SIA1)
CLUD112665513(ST8SIA1)
VVP112917220(ST8SIA1)
VLG121480215(ST8SIA1)
NPO129505598(ST8SIA1)
AML100464397(ST8SIA1)
UMR103665233(ST8SIA1)
UAH113257801(ST8SIA1)
UAR123801659(ST8SIA1)
ELK111159987
LLV125107481
MPUF101693103(ST8SIA1)
MNP132019570(ST8SIA1)
MLK131838912(ST8SIA1)
NVS122891780(ST8SIA1)
ORO101366887(ST8SIA1)
EJU114216633(ST8SIA1)
ZCA113922906(ST8SIA1)
MLX118025582(ST8SIA1)
NSU110581009(ST8SIA1)
LWW102733721(ST8SIA1)
FCA101093029(ST8SIA1)
PYU121038820(ST8SIA1)
PCOO112867675(ST8SIA1)
PBG122473547(ST8SIA1)
PVIV125171212(ST8SIA1)
LRUF124502469
PTG102962819(ST8SIA1)
PPAD109268731(ST8SIA1)
PUC125918896
AJU106967976
HHV120236008(ST8SIA1)
BTA282352(ST8SIA1)
BOM102273511(ST8SIA1)
BIU109559591(ST8SIA1)
BBUB102401968(ST8SIA1)
BBIS105000216(ST8SIA1)
CHX102187381(ST8SIA1)
OAS101117321(ST8SIA1)
BTAX128048547(ST8SIA1)
CSUM138079194(ST8SIA1)
ODA120858934(ST8SIA1)
CCAD122423333(ST8SIA1)
MREE136171647(ST8SIA1)
MBEZ129535648(ST8SIA1)
SSC100625270(ST8SIA1)
CFR102512853(ST8SIA1)
CBAI105062287(ST8SIA1)
CDK105096526(ST8SIA1)
VPC102526499(ST8SIA1)
BACU103009301(ST8SIA1)
BMUS118902638(ST8SIA1)
LVE103076775(ST8SIA1)
OOR101285691(ST8SIA1)
DLE111176840(ST8SIA1)
PCAD102987127(ST8SIA1)
PSIU116760632(ST8SIA1)
NASI112391788(ST8SIA1)
ECB100064415(ST8SIA1) 111772030 111772221 111772374
EPZ103554941(ST8SIA1)
EAI106825576(ST8SIA1)
MYB102249041(ST8SIA1)
MYD102769678
MMYO118650342(ST8SIA1)
MLF102436879(ST8SIA1)
MDT132227371(ST8SIA1)
PKL118730430(ST8SIA1)
EFUS103285148(ST8SIA1)
MNA107525320(ST8SIA1)
DRO112318440(ST8SIA1)
SHON118978440(ST8SIA1)
AJM119048980(ST8SIA1)
PDIC114513284(ST8SIA1)
PHAS123812877(ST8SIA1)
MMF118624046(ST8SIA1)
PPAM129084976(ST8SIA1)
HAI109375156(ST8SIA1)
RFQ117028889(ST8SIA1)
PALE102892181(ST8SIA1)
PGIG120618362(ST8SIA1)
PVP105306530(ST8SIA1)
RAY107508581(ST8SIA1)
MJV108398355(ST8SIA1)
TOD119247638(ST8SIA1)
SARA101536942(ST8SIA1)
SETR126022805(ST8SIA1)
LAV100659787(ST8SIA1)
TMU101359255
ETF101651002(ST8SIA1)
DNM101439062(ST8SIA1)
MDO100011205(ST8SIA1)
GAS123250017(ST8SIA1)
SHR100920916(ST8SIA1)
AFZ127539289
PCW110213804(ST8SIA1)
TVP118851960(ST8SIA1)
PBRV138175778 138176100
OAA100080234(ST8SIA1)
GGA395860(ST8SIA1)
PCOC116231405(ST8SIA1)
MGP100547921(ST8SIA1)
CJO107317147(ST8SIA1)
TPAI128084524(ST8SIA1)
LMUT125697894(ST8SIA1)
NMEL110396210(ST8SIA1)
APLA101797310(ST8SIA1)
ACYG106038258(ST8SIA1)
CATA118245122(ST8SIA1)
AFUL116502321(ST8SIA1)
TGU100225976(ST8SIA1)
LSR110470391(ST8SIA1)
SCAN103820535(ST8SIA1)
PMOA120497130(ST8SIA1)
OTC121332784(ST8SIA1)
PRUF121362718(ST8SIA1)
GFR102037290(ST8SIA1)
FAB101806998(ST8SIA1)
OMA130267021(ST8SIA1)
PHI102111773(ST8SIA1)
PMAJ107204564(ST8SIA1)
CCAE111923319(ST8SIA1)
CCW104692305(ST8SIA1)
CBRC103617289(ST8SIA1)
ETL114069418(ST8SIA1)
ZAB102064143(ST8SIA1)
ZLE135458792(ST8SIA1)
ACHL103800160(ST8SIA1)
SVG106855510(ST8SIA1)
MMEA130575566(ST8SIA1)
HRT120751890(ST8SIA1)
SATI136361524(ST8SIA1)
FPG101922614(ST8SIA1)
FCH102056471(ST8SIA1)
CCRI104168338(ST8SIA1)
NNT104403606(ST8SIA1)
SHAB115605291(ST8SIA1)
ACUN113487646(ST8SIA1)
TALA104365612(ST8SIA1)
ACHC115352512(ST8SIA1)
AGEN126047785
GCL127019811
CSTI104564133(ST8SIA1)
LDI104347216(ST8SIA1)
DPUB104299482(ST8SIA1)
PPUS135182124(ST8SIA1)
BRHI104489776
EGZ104135090(ST8SIA1)
NNI104012705(ST8SIA1)
PCRI104034257
PCAO104043589(ST8SIA1)
PADL103924330(ST8SIA1)
AFOR103898734(ST8SIA1)
CLV102093502(ST8SIA1)
PGUU104466166
CMAC104479213
CUCA104059493(ST8SIA1)
TEO104372828(ST8SIA1)
OHA104327191(ST8SIA1)
ACAR104521623(ST8SIA1)
CPEA104393457(ST8SIA1)
CVF104281725(ST8SIA1)
RTD128910513(ST8SIA1)
AAM106488295(ST8SIA1)
AROW112966614(ST8SIA1)
NPD112944369(ST8SIA1)
TGT104578998(ST8SIA1)
DNE112978905(ST8SIA1)
SCAM104154118(ST8SIA1)
ASN102378302(ST8SIA1)
AMJ102562267(ST8SIA1)
CPOO109316395(ST8SIA1)
GGN109296296(ST8SIA1)
PSS102462829(ST8SIA1)
CMY102943965(ST8SIA1)
CCAY125625048(ST8SIA1)
DCC119850214(ST8SIA1)
CPIC101937464(ST8SIA1)
TST117883367(ST8SIA1)
CABI116835477(ST8SIA1)
MRV120371084(ST8SIA1)
ACS100337536(st8sia1)
ASAO132775711(ST8SIA1)
PVT110091198(ST8SIA1)
SUND121930321(ST8SIA1)
PBI103065178(ST8SIA1)
PMUR107295788(ST8SIA1)
CTIG120309794(ST8SIA1)
TSR106547779(ST8SIA1)
PGUT117679860(ST8SIA1)
APRI131202524(ST8SIA1)
PTEX113437871(ST8SIA1)
NSS113419064(ST8SIA1)
VKO123034657(ST8SIA1)
PMUA114605143(ST8SIA1)
PRAF128422080(ST8SIA1)
ZVI118091196(ST8SIA1)
HCG128327158(ST8SIA1)
GJA107105667
STOW125434326(ST8SIA1)
EMC129336057(ST8SIA1)
XLA108712513(st8sia1.S) 398735(st8sia1.L)
XTR444887(st8sia1)
NPR108789879(ST8SIA1)
RTEM120932763(ST8SIA1)
BBUF121005110(ST8SIA1)
BGAR122926561(ST8SIA1)
DRE553210(st8sia1)
SRX107748471 107755164
SANH107689712(st8sia1)
SGH107567669
CCAR109045336 109066147
CAUA113048254 113061141
CGIB127956856 127972491
PTET122342725(st8sia1)
LROH127164321(st8sia1)
OMC131539055(st8sia1)
PPRM120477091(st8sia1)
RKG130092533(st8sia1)
MAMB125245379(st8sia1)
CIDE127511328
CERY137023976(st8sia1)
MASI127435346 127436847
TROS130547566(st8sia1)
TDW130420284(st8sia1)
MANU129432559(st8sia1)
IPU108279455(st8sia1) 108279490
IFU128623476(st8sia1) 128623558
PHYP113531749(st8sia1)
SMEO124401145(st8sia1)
TFD113647226(st8sia1)
TVC132859374(st8sia1)
TRN134324994(st8sia1)
AMEX103035159(st8sia1)
CMAO118812360(st8sia1)
EEE113584008(st8sia1)
CHAR105889648(st8sia1) 105892368 105892371 105892372 105909703 116219229
TRU445978(st8sia1)
TFS130519207(st8sia1)
TNGGSTEN00020858G001
LCO109141779(st8sia1)
NCC104958359(st8sia1)
TBEN117485063(st8sia1)
CGOB115028360(st8sia1)
PGEO117439298(st8sia1)
GACU117547931(st8sia1)
EMAC134879382(st8sia1)
ELY117249341(st8sia1)
EFO125882523(st8sia1)
PLEP121961498(st8sia1)
SLUC116060120(st8sia1)
ECRA117938764(st8sia1)
ESP116673185(st8sia1)
PFLV114550187(st8sia1)
GAT100174872
PPUG119211090(st8sia1)
AFB129112618(st8sia1)
CLUM117726120(st8sia1)
PSWI130200293(st8sia1)
CANA137791408(st8sia1)
CVE137880146(st8sia1)
MSAM119918439(st8sia1)
SCHU122871344(st8sia1)
CUD121505444(st8sia1)
ALAT119032673(st8sia1)
ASTR137589233(st8sia1)
MZE101480363(st8sia1)
ONL100695121(st8sia1)
OAU116309833(st8sia1)
OLA100049518(st8sia1)
OML112155472(st8sia1)
CSAI133423960(st8sia1)
XMA102218717(st8sia1)
XCO114141471(st8sia1)
XHE116736502(st8sia1)
PRET103459243(st8sia1)
PFOR103146226(st8sia1)
PLAI106961373 106961377
PMEI106931844(st8sia1)
GAF122826653(st8sia1)
PPRL129375504(st8sia1)
CVG107085992(st8sia1)
CTUL119785664(st8sia1)
GMU124883158(st8sia1)
NFU107379800(st8sia1)
KMR108235108(st8sia1)
ALIM106533543(st8sia1)
NWH119428390(st8sia1)
AOCE111571510(st8sia1)
EJA138207524(st8sia1)
MCEP125000032(st8sia1)
CSEM103382754(st8sia1)
POV109632888(st8sia1)
SSEN122767240(st8sia1)
HHIP117756967(st8sia1)
HSP118101632(st8sia1)
PPLT128428642
SMAU118287693(st8sia1)
LCF108879661
SDU111224971(st8sia1)
SLAL111671912(st8sia1)
XGL120802191(st8sia1)
HCQ109523778(st8sia1)
SSCV125992241(st8sia1)
SBIA133493589(st8sia1)
PEE133396986(st8sia1)
PTAO133471915(st8sia1)
BPEC110170325(st8sia1)
MALB109959852(st8sia1)
BSPL114862095(st8sia1)
SJO128353385(st8sia1)
SASA106595526 106609639(st8sia1)
STRU115180086 115199122
OTW112242451(st8sia1)
OMY110499835 118936578
OGO124026144(st8sia1)
ONE115114980
OKI109879214(st8sia1)
OKE118372698(st8sia1)
SNH120036006 120040271
CCLU121543396 121549897
ELS105020361(st8sia1)
SFM108936438 108942102
PKI111846118 111846528
AANG118219081(st8sia1) 118231201
LOC102694617(st8sia1)
PSPA121318379 121319722
ARUT117414707 117419486
PSEX120534204(st8sia1)
LCM102350065(ST8SIA1)
CMK103181078(st8sia1)
RTP109917984(st8sia1)
CPLA122561586(st8sia1)
HOC132826941(st8sia1)
LERI129707670
PMRN103091726(ST8SIA1)
LRJ133351486(ST8SIA1)
LPIC129272954 129272955
ARUN117302666
 » show all
Reference
1  [PMID:7407217]
  Authors
Eppler CM, Morre DJ, Keenan TW.
  Title
Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.
  Journal
Biochim Biophys Acta 619:332-43 (1980)
DOI:10.1016/0005-2760(80)90081-8
Reference
2  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 260:824-8 (1985)
Reference
3  [PMID:4044605]
  Authors
McCoy RD, Vimr ER, Troy FA.
  Title
CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.
  Journal
J Biol Chem 260:12695-9 (1985)
Reference
4  [PMID:6766128]
  Authors
Yohe HC, Yu RK.
  Title
In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.
  Journal
J Biol Chem 255:608-13 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.3.8
IUBMB Enzyme Nomenclature: 2.4.3.8
ExPASy - ENZYME nomenclature database: 2.4.3.8
BRENDA, the Enzyme Database: 2.4.3.8
CAS: 67339-00-8
LinkDB

KEGG   REACTION: R05947
Entry
R05947                      Reaction                               
Definition
CMP-N-acetylneuraminate + GD3 <=> CMP + GT3
Equation
Comment
Siat8e
Enzyme
Pathway
rn00604  Glycosphingolipid biosynthesis - ganglio series
rn01100  Metabolic pathways
Module
M00069  Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.3  Sialyltransferases
    2.4.3.8
     R05947  CMP-N-acetylneuraminate + GD3 <=> CMP + GT3
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.4.3.8
   R04564  alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-R <=> alpha-N-Acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R
    R05947  GD3 <=> GT3
Glycosyltransferase reactions [BR:br08203]
 Sialyltransferase reactions
  R05947  Neu5Ac a2-8 Neu5Ac
Orthology
K03369  alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8E) [EC:2.4.3.-]
K03371  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A) [EC:2.4.3.8]
LinkDB

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