Entry
Name
lipoate---protein ligase;
lplA (gene name);
lplJ (gene name);
lipoate protein ligase;
lipoate-protein ligase A;
LPL;
LPL-B
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname
[lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming)
Reaction(IUBMB)
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction) [RN:
R11143 ];
(1a) ATP + (R)-lipoate = lipoyl-AMP + diphosphate [RN:
R07770 ];
(1b) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP [RN:
R07771 ]
Reaction(KEGG)
Substrate
Product
[lipoyl-carrier protein]-N6-(lipoyl)lysine [CPD:
C16237 ];
AMP [CPD:
C00020 ];
diphosphate [CPD:
C00013 ];
lipoyl-AMP [CPD:
C16238 ]
Comment
Requires Mg2+. This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid [7]. The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [6]. Lipoylation is essential for the function of these enzymes. The enzyme can also use octanoate instead of lipoate.
History
EC 6.3.1.20 created 2006 as EC 2.7.7.63, transferred 2016 to EC 6.3.1.20
Pathway
Orthology
K03800 lipoate---protein ligase
Genes
NTE : NEUTE1DRAFT65646(NEUTE1DRAFT_65646)
ALUC : AKAW2_31034A(AIM22)
CCAC : CcaHIS019_0508070(CcaverHIS019_0508070)
ABP : AGABI1DRAFT72757(AGABI1DRAFT_72757)
ABV : AGABI2DRAFT211723(AGABI2DRAFT_211723)
SCM : SCHCO_02621184(SCHCODRAFT_02621184)
PSTR : Pst134EA_019167 Pst134EA_019172 Pst134EA_031526
PMAL : PMUG01_14031300(LipL1)
PREL : PRELSG_1412500(LipL1)
TET : TTHERM_00535630 TTHERM_01075670
SMIN : v1.2.016157.t1(symbB.v1.2.016157.t1)
TCR : 509611.100 510857.50
ECW : EcE24377A_4985(lplA)
EDJ : ECDH1ME8569_4242(lplA)
ECOI : ECOPMV1_04846(lplA)
SEM : STMDT12_C47010(lplA)
SETC : CFSAN001921_17545(lplA)
SEEN : SE451236_05900(lplA)
SENH : CFSAN002069_09320(lplA)
SEEH : SEEH1578_08920(lplA)
SENJ : CFSAN001992_11155(lplA)
SEEC : CFSAN002050_06365(lplA)
SEEB : SEEB0189_019500(lplA)
SENC : SEET0819_06790(lplA)
REE : electrica_04337(lplA)
RTG : NCTC13098_06352(lplA_2)
CLAP : NCTC11466_03927(lplA)
KIE : NCTC12125_03070(lplA)
BAGE : BADSM9389_06010(lplA)
AHN : NCTC12129_00708(lplA_2)
METY : MRY16398_48430(lplA)
PSHI : SAMEA2665130_1872(lplA)
SMW : SMWW4_v1c21910(lplA)
SERS : SERRSCBI_10275(lplA)
SERA : Ser39006_011950(lplA)
SFJ : SAMEA4384070_2220(lplA)
SOF : NCTC11214_04672(lplA)
PLF : PANA5342_p10262(lplA)
PVA : Pvag_pPag30250(lplA)
PHEI : NCTC12003_02326(lplA)
PRJ : NCTC6933_01649(lplA)
LRI : NCTC12151_01719(lplA)
LLZ : LYB30171_01170(lipM)
FED : LQ772_12590 LQ772_12595
VPL : SA104470976_01133(lplA)
PPR : PBPRB1373 PBPRB1808(LPLA)
PSYC : DABAL43B_0236(lplA)
HHC : M911_11190 M911_12655 M911_13110
EBS : ECTOBSL9_0277 ECTOBSL9_0597 ECTOBSL9_2126
TNI : TVNIR_1885(lplJ_[H])
APRS : BI364_05090 BI364_13765
GAI : IMCC3135_18605(lplA)
AEL : NCTC12917_02942(lplA)
CHJ : NCTC10426_01432(lplJ)
ACII : C4901_01305 C4901_03775 C4901_12930 C4901_15015
ATY : A9R16_001130 A9R16_004040 A9R16_012695
CDIZ : CEDIAZO_03289(lplA)
LMIR : NCTC12852_00971 NCTC12852_01467(lplA)
BHZ : ACR54_00419(lipM) ACR54_02585(lplA)
BTRM : SAMEA390648703375(lplA)
AXX : ERS451415_02527(lplA)
ADN : Alide_0400 Alide_2337
ADK : Alide2_0345 Alide2_2531
OTO : ADJ79_00170 ADJ79_12665
SDR : SCD_n00426 SCD_n00803
NEN : NCHU2750_46950(lplA)
AFE : Lferr_2173 Lferr_2343
AFI : Acife_2466 Acife_3277
AFJ : AFERRID_05050 AFERRID_06760
DEK : DSLASN_13920 DSLASN_13960
DTI : Desti_0239 Desti_0742
BREY : MNR06_01505 MNR06_01515
BAZ : BAMTA208_04810(yhfJ)
BFD : NCTC4823_02826(lplJ)
OCN : CUC15_07350 CUC15_13780
VNT : OLD84_02150 OLD84_07145
VIK : KFZ58_01405 KFZ58_06905
LAO : AOX59_08700 AOX59_12450
LEX : Len3610_01125 Len3610_01870
BLEN : NCTC4824_03014(lplJ)
FHL : OE105_02540 OE105_03360
FAF : OE104_07685 OE104_08615
PUK : PU629_04055 PU629_12590
SAH : SaurJH1_0386 SaurJH1_1108
SAJ : SaurJH9_0376 SaurJH9_1086
SAX : USA300HOU_0348(lplA1)
SAA : SAUSA300_0328 SAUSA300_0930
SAO : SAOUHSC_00308 SAOUHSC_00963
SUU : M013TW_0308 M013TW_0956
SUV : SAVC_01385 SAVC_04300
SUE : SAOV_0353 SAOV_0973c
SUJ : SAA6159_00303 SAA6159_00883
SUK : SAA6008_00304(lplA1) SAA6008_00982
SUT : SAT0131_00332 SAT0131_01062
SUQ : HMPREF0772_10168 HMPREF0772_12207
SUZ : MS7_0317 MS7_0985(lplJ)
SUD : ST398NM01_0408 ST398NM01_1025
SUX : SAEMRSA15_02830 SAEMRSA15_08570
SUW : SATW20_03950 SATW20_10240
SUF : SARLGA251_02890 SARLGA251_09420
SAUA : SAAG_00815 SAAG_02136
SAUE : RSAU_000273 RSAU_000914
SAUN : SAKOR_00322 SAKOR_00946
SAUS : SA40_0285 SA40_0897
SAUU : SA957_0300 SA957_0912
SAUG : SA268_0297 SA268_0914
SAUZ : SAZ172_0328 SAZ172_0968
SAUT : SAI1T1_2002520 SAI1T1_2007290
SAUJ : SAI2T2_1002520 SAI2T2_1007310
SAUK : SAI3T3_1002520 SAI3T3_1007300
SAUQ : SAI4T8_1002520 SAI4T8_1007290
SAUV : SAI7S6_1002520 SAI7S6_1007300
SAUW : SAI5S5_1002510 SAI5S5_1007260
SAUX : SAI6T6_1002520 SAI6T6_1007270
SAUY : SAI8T7_1002520 SAI8T7_1007300
SAUF : X998_0384 X998_1027
SUY : SA2981_0326 SA2981_0981
SAUB : C248_0381 C248_1052
SAUM : BN843_3330 BN843_9340
SAUC : CA347_341 CA347_946(lplJ)
SAUR : SABB_00995 SABB_01521
SAUI : AZ30_01680 AZ30_04895
SAUD : CH52_00740 CH52_04090
SAMS : NI36_01550 NI36_04900
SUH : SAMSHR1132_03010 SAMSHR1132_08740
SHH : ShL2_00179(lplA1) ShL2_01793
SLG : SLGD_00254 SLGD_01841
SLN : SLUG_02530 SLUG_18350
SDP : NCTC12225_02014(lplJ)
SXY : BE24_02485 BE24_11115
SXL : SXYLSMQ121_0195 SXYLSMQ121_1757
SXO : SXYL_00194 SXYL_01905
SEQO : SE1039_07820 SE1039_23880
SCOH : BZ166_00710 BZ166_05505
SNL : BJD96_01270 BJD96_09750
SPIC : SAMEA4384060_1920(lplJ)
SSH : NCTC13712_00275(lplJ_1) NCTC13712_00973(lplJ_2)
SSIM : SAMEA4384339_0276(lplJ_1) SAMEA4384339_0878(lplJ_2)
SAUL : I6G39_01020 I6G39_08125
SPSD : JMB28_01515 JMB28_09520
STAS : HYI43_01035 HYI43_09035
SURY : MUA21_03670 MUA21_11770
SEDA : MNY58_01075 MNY58_09425
SDEV : Q2T90_06140 Q2T90_10360
SROT : ML435_01415 ML435_04650
SSTE : SAMEA4384403_1827(lplJ)
MLEN : H3V22_08215 H3V22_13450
JEA : JEM45_00415 JEM45_10820
NAMP : KPF49_05510 KPF49_06770
NMY : CJ229_003370 CJ229_004815
LMN : LM5578_0844 LM5578_1012
LMY : LM5923_0799 LM5923_0966
LMT : LMRG_00452 LMRG_02030
LMOC : LMOSLCC5850_0764 LMOSLCC5850_0933
LMOE : BN418_0882 BN418_1132 BN418_1133
LMOB : BN419_0889 BN419_1134 BN419_1135
LMOD : LMON_0768 LMON_0937
LMOW : AX10_12360 AX10_13215
LMOQ : LM6179_01076(lplA2) LM6179_01246(lplA1)
LMR : LMR479A_0783(lplJ) LMR479A_0953(lplJ)
LMOM : IJ09_05645 IJ09_06505
LMF : LMOf2365_0788 LMOf2365_0952
LMC : Lm4b_00780 Lm4b_00950
LMOG : BN389_07970(lplJ) BN389_09610(lplJ_2)
LMOL : LMOL312_0764 LMOL312_0932
LMOJ : LM220_04131 LM220_10872
LMOZ : LM1816_00720 LM1816_12992
LMOX : AX24_01140 AX24_02030
LMH : LMHCC_1691 LMHCC_1864
LMQ : LMM7_0795(lplA) LMM7_0967(lplA)
LML : lmo4a_0776 lmo4a_0946
LMG : LMKG_01113 LMKG_02361
LMJ : LMOG_00798 LMOG_01970
LMW : LMOSLCC2755_0765 LMOSLCC2755_0932
LMX : LMOSLCC2372_0774 LMOSLCC2372_0944
LMZ : LMOSLCC2482_0808 LMOSLCC2482_0976
LMON : LMOSLCC2376_0731 LMOSLCC2376_0902
LMOS : LMOSLCC7179_0741 LMOSLCC7179_0911
LMOO : LMOSLCC2378_0784 LMOSLCC2378_0948
LMOY : LMOSLCC2479_0772 LMOSLCC2479_0943
LMOT : LMOSLCC2540_0764 LMOSLCC2540_0930
LMOA : LMOATCC19117_0788 LMOATCC19117_0953
LMOK : CQ02_04030 CQ02_04870
LMV : Y193_11095 Y193_11970
LII : JL52_03800 JL52_04680
LIW : AX25_03870 AX25_04760
LIA : JL58_03880 JL58_04885
LIO : JL53_04420 JL53_05365
LWI : UE46_05775 UE46_06090
LGZ : NCTC10812_01951(lplJ_1) NCTC10812_02122(lplJ_2)
LMAR : LAX80_003480(lplA2) LAX80_004270(lplA1)
LNW : OTR81_15415 OTR81_15710
GMO : NCTC11323_01396(lplJ)
GHA : NCTC10459_00022(lplJ_1) NCTC10459_00024(lplJ_2) NCTC10459_01419(lplJ_3)