KEGG ORTHOLOGY: K03879

ORTHOLOGY: K03879

Entry

K03879                      KO

Symbol

ND2

Name

NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04714

Thermogenesis

map04723

Retrograde endocannabinoid signaling

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00142

NADH:ubiquinone oxidoreductase, mitochondria

Reaction

R11945

NADH:ubiquinone oxidoreductase

Disease

H00068

Leber hereditary optic atrophy

H00473

Mitochondrial complex I deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
   05012 Parkinson disease
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
   05014 Amyotrophic lateral sclerosis
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
   05016 Huntington disease
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
   05020 Prion disease
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
   05022 Pathways of neurodegeneration - multiple diseases
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
Enzymes [BR:ko01000]
7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.2  NADH:ubiquinone reductase (H+-translocating)
     K03879  ND2; NADH-ubiquinone oxidoreductase chain 2
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    K03879  ND2; NADH-ubiquinone oxidoreductase chain 2

Other DBs

GO:

0008137

TC:

3.D.1.6

Genes

HSA:

4536(ND2)

PTR:	807865(ND2)

PPS:	807883(ND2)

GGO:	6742677(ND2)

PON:	808478(ND2)

PPYG:

807907(ND2)

NLE:	16545240(ND2)

SSYN:

9072795(ND2)

MCC:	2846626(ND2)

MCF:	7857750(ND2)

CSAB:

4097489(ND2)

CATY:

26408637(ND2)

PANU:

14444630(ND2)

TGE:	14216782(ND2)

RRO:	4171535(ND2)

RBB:	10549368(ND2)

TFN:	18985073(ND2)

CJC:	22203901(ND2)

SBQ:	13228912(ND2)

ANAN:

13230267(ND2)

CSYR:

7944462(ND2)

MMUR:

26823994(ND2)

LCAT:

68929177(ND2)

PCOQ:

6458121(ND2)

MMU:	17717(ND2)

MCAL:

20832243(ND2)

MPAH:

36165352(ND2)

RNO:	26194(ND2)

MCOC:

34682993(ND2)

MUN:	18129806(ND2)

CGE:	3979184(ND2)

MAUA:

8457924(ND2)

PROB:

30213866(BOP69_gp12)

PLEU:

36275547(ND2)

NGI:	15088424(ND2)

HGL:	10201215(ND2)

CPOC:

808632(ND2)

CCAN:

31082897(ND2)

OCU:	808230(ND2)

OPI:	2717281(ND2)

GVR:	804979(ND2)

CFA:	804477(ND2)

VVP:	4355758(ND2)

VLG:	23629747(ND2)

NPO:	8690241(ND2)

AML:	5179725(ND2)

UMR:	804862(ND2)

UAR:	804834(ND2)

LLV:	71922406(ND2)

MNP:	20466139(ND2)

NVS:	14841840(ND2)

EJU:	805011(ND2)

ZCA:	4355795(ND2)

MLX:	4355871(ND2)

LWW:	4355833(ND2)

FCA:	807935(ND2)

PYU:	26129867(ND2)

PCOO:

11473379(ND2)

PBG:	26129487(ND2)

PVIV:

26129639(ND2)

PPAD:

6262376(ND2)

PUC:	6262405(ND2)

AJU:	2654019(ND2)

HHV:	14842156(ND2)

BTA:	3283878(ND2)

BOM:	22161767(ND2)

BIU:	2885976(ND2)

BBUB:

56055849(ND2)

CHX:	1485857(ND2)

OAS:	808250(ND2)

BTAX:

8250973(ND2)

ODA:	11452039(ND2)

CCAD:

59433132(ND2)

MBEZ:

7872543(ND2)

SSC:	808502(ND2)

CFR:	5326218(ND2)

CBAI:

5309937(ND2)

CDK:	5618961(ND2)

VPC:	809424(ND2)

BMUS:

807736(ND2)

LVE:	3802093(ND2)

OOR:	72909413(ND2)

DLE:	31412980(ND2)

PCAD:

809419(ND2)

ECB:	807844(ND2)

EPZ:	19019453(ND2)

EAI:	808059(ND2)

MYB:	20964693(ND2)

MYD:	22203929(ND2)

MMYO:

26889520(ND2)

MLF:	27214812(ND2)

DRO:	17046643(ND2)

AJM:	808337(ND2)

PDIC:

74550846(ND2)

HAI:	13539866(ND2)

PALE:

17963485(ND2)

RAY:	3666158(ND2)

MJV:	24019670(ND2)

TOD:	38289013(D9W85_mgp12)

LAV:	808792(ND2)

ETF:	802331(ND2)

DNM:	808135(ND2)

MDO:	3074668(ND2)

GAS:	63652830(ND2)

SHR:	13826439(ND2)

AFZ:	65342074(ND2)

PCW:	4108303(ND2)

TVP:	803527(ND2)

OAA:	808700(ND2)

GGA:	39116929(ND2)

PCOC:

10609897(ND2)

MGP:	5848009(ND2)

CJO:	804667(ND2)

LMUT:

31079460(ND2)

NMEL:

32282784(ND2)

APLA:

5405821(ND2)

ACYG:

18887299(ND2)

CATA:

7996698(ND2)

AFUL:

19909396(ND2)

TGU:	3950791(ND2)

SCAN:

37275771(ND2)

PMOA:

20355697(ND2)

OTC:	22548459(ND2)

PRUF:

17674389(ND2)

FAB:	16027866(ND2)

PHI:	9480993(ND2)

PMAJ:

39089578(ND2)

CCW:	71712374(ND2)

MMEA:

130587654 20357133(ND2)

SATI:

5846208(ND2)

FPG:	808588(ND2)

FCH:	23808610(ND2)

AGEN:

7256438(ND2)

EGZ:	18985248(ND2)

NNI:	4108699(ND2)

PADL:

26737704(ND2)

GSTE:

3416061(ND2)

CLV:	8889996(ND2)

RTD:	84348647(ND2)

AROW:

62676602(ND2)

NPD:	62676503(ND2)

DNE:	803267(ND2)

ASN:	806141(ND2)

AMJ:	808246(ND2)

CPOO:

4108091(ND2)

GGN:	4178389(ND2)

PSS:	2943118(ND2)

CMY:	808652(ND2)

CCAY:

11747771(ND2)

CPIC:

18982995(ND2)

CABI:

60253665(ND2)

ACS:	6385980(ND2)

PVT:	3338343(ND2)

PBI:	YP_008083600

PMUR:

15822631(ND2)

APRI:

131195785

PMUA:

7056461(ND2)

ZVI:	24146095(YC27_gp12)

GJA:	26044422(ND2)

EMC:	30861812(ND2)

XLA:	2642087(ND2)

XTR:	3283493(ND2)

NPR:	24020212(ND2)

BGAR:

4356059(ND2)

MUO:	18490089(ND2)

GSH:	14469870(ND2)

DRE:	140532(ND2)

SRX:	24419155(ND2)

SANH:

24419945(ND2)

SGH:	8382163(ND2)

CCAR:

807766(ND2)

CGIB:

9222065(ND2)

PTET:

5787387(ND2)

LROH:

12079591(ND2)

OMC:	18668118(ND2)

PPRM:

26048337(ND2)

RKG:	130077634 130077637 130077640 130077643

MAMB:

5912303(ND2)

CIDE:

5857718(ND2)

CERY:

20160548(ND2)

MASI:

3131141(ND2)

TROS:

14048436(ND2)

TDW:	36952185(ND2)

MANU:

6879710(ND2)

IPU:	804883(ND2)

IFU:	26118480(ND2)

PHYP:

16216568(ND2)

SMEO:

10079898(ND2)

TVC:	10079787(ND2) 132858794

TRN:	134307553 134307559 134307591 134307598

CHAR:

5228444(ND2)

TRU:	805217(ND2)

TFS:	19524532(ND2)

TNG:	BAE79218(ND2)

LCO:	7095382(ND2)

NCC:	10752023(ND2)

PGEO:

67284287(ND2)

EMAC:

30862031(ND2)

ELY:	7095517(ND2)

EFO:	14412328(ND2)

PLEP:

4363283(ND2)

SLUC:

23629803(ND2)

ESP:	40141429(ND2)

PFLV:

14048210(ND2)

PPUG:

119199128 7042822(ND2)

AFB:	13230429(ND2)

PSWI:

72130134(ND2)

MSAM:

4100026(ND2)

SCHU:

10965120(ND2)

CUD:	8774885(ND2)

MZE:	26037637(APK84_gp12)

ONL:	8677312(ND2)

OAU:	8745940(ND2)

OLA:	805440(ND2)

OML:	13540108(ND2)

CSAI:

804088(ND2)

XMA:	6986209(ND2)

XCO:	26048185(ND2)

XHE:	8302519(ND2)

PRET:

19590714(ND2)

GAF:	805450(ND2)

CVG:	26048375(ND2)

CTUL:

26129145(ND2)

NFU:	7256389(ND2)

KMR:	804467(ND2)

AOCE:

4850675(ND2)

CSEM:

7996492(ND2)

POV:	808838(ND2)

SSEN:

4266846(ND2)

HHIP:

5405721(ND2)

HSP:	5405779(ND2)

SMAU:

8382073(ND2)

LCF:	3703588(ND2)

SDU:	11669687(ND2)

XGL:	7871600(ND2)

HCQ:	14658011(ND2)

SSCV:

125966257

SBIA:

35996581(ND2)

PTAO:

74193744(ND2)

BPEC:

YP_004935132.1

MALB:

803938(ND2)

BSPL:

23631936(ND2)

SJO:	8703819(ND2)

SASA:

808316(ND2)

STRU:

19099176(ND2)

OTW:	KEF73_p12(ND2)

OMY:	807979(ND2)

OGO:	6383212(ND2)

ONE:	4555711(ND2)

OKI:	4955087(ND2)

OKE:	12486860(ND2)

SALP:

808545(ND2)

SNH:	35115214(ND2)

CCLU:

14842632(ND2)

ELS:	806646(ND2)

SFM:	3416105(ND2)

AANG:

3190266(ND2)

LOC:	807197(ND2)

PSPA:

805405(ND2)

ARUT:

17097819(ND2)

LCM:	808084(ND2)

CMK:	9385345(ND2)

RTP:	18267177(ND2)

CPLA:

7768743(ND2)

LERI:

11452179(ND2)

PMRN:

807814(ND2)

LRJ:	9385088(ND2)

BFO:	808738(ND2)

BBEL:

806240(ND2)

SCLV:

36165638(ND2)

SPU:	2652717(ND2)

APLC:

110990861 3907680(ND2)

SKO:	3703612(ND2)

DME:	Dmel_CG34063(ND2)

DSE:	2760951(ND2)

DSI:

ND2

DYA:

ND2

DAN:

26515184

DPO:	117185108 26532037

DMN:	117194308 117194314

DGR:

116806150

CCAT:

110118211 808525(ND2)

BOD:	2717264(ND2)

BDR:	4657582(ND2)

AOQ:	79023071(ND2)

TDA:

119688821

MDE:	20358592(ND2)

LSQ:	5469274(ND2)

ECOE:

35199145(ND2)

HIS:	33350925(ND2)

AGA:	85940915(ND2)

ACOZ:

26121317(ND2)

AARA:

26121203(ND2)

AMER:

26121507(ND2)

AFUN:

76054167(ND2)

AMOU:

73620839(ND2)

AAG:	33307554(ND2)

AALB:

3260123(ND2)

CQU:

ND2

CPII:

10200340(ND2)

BCOO:

119084560

ACER:

9385650(ND2)

ALAB:

34829157(ND2)

AFLR:

15822495(ND2)

SOC:	9977801(ND2)

VEM:	27912153(ND2)

LHU:	42265463(ND2)

VVE:	33194923(ND2)

AGIF:

63649813(ND2)

CCIN:

7872304(ND2)

TCA:	803823(ND2)

SOY:	28481398(ND2)

ATD:	34926354(ND2)

CSET:

123313380

AGB:	4171596(ND2)

LDC:

111506462

APLN:

28479666(ND2)

BMOR:

809265(ND2)

BMAN:

804652(ND2)

MSEX:

5848759(ND2)

DPL:	AGL76298(ND2)

BANY:

128199787 128199790

PMAC:

106711768 13080340(ND2)

PPOT:

106110404 20159566(ND2)

PXU:	106121442 26836900(ND2)

PRAP:

11030477(ND2)

PBX:

123718343

PNAP:

125062050 60241340(ND2)

ZCE:

119839406

HAW:	9977724(ND2)

HZE:	124645587 124645588 71203121(ND2)

TNL:	113502838 113502922 44149129(ND2)

SLIU:

17427408(ND2)

ATRA:

26281588(ND2)

GMW:	26376085(ND2)

PXY:	20834458(ND2)

PGW:	73956675(ND2)

API:	7055887(ND2)

DNX:	17428421(ND2)

AGS:	19909112(ND2)

BTAB:

3077230(ND2)

DCI:	27914400(ND2)

CLEC:

27787560(ND2)

HHAL:

8457894(ND2)

NLU:	16216538(ND2)

HVI:	3332280(ND2)

MQU:	32891616(ND2)

FOC:	YP_006576362

TPAL:

38092121(ND2)

ZNE:	20004831(ND2)

SGRE:

73491788(ND2)

DPX:	AAD33230(ND2)

DMK:	24147202(ND2)

PVM:	5333216(ND2)

PJA:	3416047(ND2)

PCHN:

5333404(ND2)

PMOO:

808982(ND2)

HAME:

10743683(ND2)

PCLA:

11763608(ND2)

CQD:	17728534(ND2)

PTRU:

1482829(ND2)

ESN:	3355546(ND2)

MNZ:	10200255(ND2)

MRJ:	3293138(ND2)

HAZT:

38169096(ND2)

EAF:	54124843(ND2)

TCF:	4788313(ND2)

DSV:	23630430(ND2)

RSAN:

808361(ND2)

RMP:	18250947(ND2)

VDE:	806161(ND2)

TUT:	6164214(ND2)

DPTE:

7564655(ND2)

ABRU:

19591992(ND2)

LPOL:

803776(ND2)

CEL:	KEF34_p08(ND2)

CBR:

ND2

NAI:	804825(ND2)

LOA:

ND2

TSP:

ND2

PCAN:

19909190(ND2)

BGT:	2746313(ND2)

HRF:	35985181(ND2)

HRJ:	2846690(ND2)

CRG:	808826(ND2)

CANU:

7865911(ND2)

MYI:	4910448(ND2)

MMER:

55289767(ND2)

RPHI:

29141297(ND2)

OBI:	106869121 27205956(ND2)

OSN:	62676621(ND2)

LAK:	C2G87_mgp12(ND2)

SMM:

ND2

SHX:	4097436(ND2)

ATEN:

41854790(ND2)

ADF:	17674589(ND2)

PDAM:

5580395(ND2)

SPIS:

6798781(ND2)

DGT:	8656272(ND2)

XEN:	124455309 124455316 124455317

HMG:	6904228(ND2)

HSY:	130626408 130626440

RES:	33911776(ND2)

TAD:	TradoM_p10(ND2)

AQU:	4794351(ND2)

ATH:	AT2G07689 DA397_mgp31(nad2)

CRB:	40490664(nad2)

EUS:	EUTSA_v10015951mg

BRP:	56141084(nad2)

BNA:	4237887(nad2)

RSZ:	13630161(nad2)

CPAP:

7441423(nad2)

CIT:	36487064(nad2)

GRA:	27429583(nad2)

GAB:	33134422(nad2)

HSYR:

120202671

EGR:	120288250 38466617(nad2)

GMX:	15308633(nad2)

VRA:

106779391

VAR:	15382820(nad2)

VUN:

114192993

CCAJ:

109793480 109793583

MTR:	120577846 26974329(nad2)

TPRA:

55290666(nad2)

PSAT:

127107514 127107516 127119353

VVO:

ADU:

AHF:

PCIN:

PMUM:

MDM:	13630220(nad2)

MSYL:

73938917(nad2)

ZJU:	27215290(nad2)

MNT:	39338982(nad2)

CSAV:

27215502(nad2)

CSV:	11123895(nad2)

CMO:	127146615 127146702 127147997 127148203 127149812 127150905 127150986

BHJ:

120070876

MCHA:

111025687

RCU:	10221400(nad2)

MEAN:

126655377

HBR:

110654472

MESC:

42317545(nad2)

POP:

112326444

PEU:

105138835

PALZ:

39331284(nad2)

QSU:

136071597

QLO:

115952279

TWL:

120001542

VVI:	7498551(nad2)

VRI:

117923747

SPEN:

34925969(nad2)

SOT:

102603210

CANN:

124886983 19988969(nad2)

NTA:	3205197(nad2) 3205259(orf214)

NSY:	27214829(nad2) 27214857(nad2) 27214864(nad2)

NAU:	35198932(nad2)

INI:	29082055(nad2)

SIND:

105155298 110011718

SSPL:

121789896

SMIL:

18126413(nad2)

APAN:

127253053

ECAD:

122584409

LSV:	40498736(nad2)

CCAV:

112506054

DCR:	88614165(nad2)

CSIN:

40867533(nad2)

AEW:	88577598(nad2)

BVG:	809516(orf300) 809520(nad2)

SOE:	110802001 33876625(nad2)

CQI:	39331955(nad2)

NNU:	28482668(nad2)

MING:

122081814

TSS:	122647145 122647659

OSA:	6450140(nad2)

TAES:

123040764 123048612 123060510 123091833 123102063 123102877 123102881 123144429 123146145 123156862 123165021 123180197 34688810(nad2)

TUA:	125519794 125522492 125530740 125531833 125536610 125550437 125551606

LPER:

127307002

SBI:	4306038(nad2)

SVS:

117848589

PVIR:

120693837 120694099

PDA:	11542591(nad2)

MUS:

103973027

PEQ:	110030394 110036994

MSIN:

131219080

NCOL:

36487377(nad2)

SMO:	SELMODRAFT_138433

PPP:	3989055(nad2)

CRE:	ChrepMp05(nad2)

CSL:	CospCoM_p24(nad2)

CVR:	OJ20_p17(nad2)

APRO:

ChprMp016(nad2)

OTA:	OstapMp34(nad2)

BPG:	BathyMg00060(nad2)

MIS:	MicpuN_mit23(nad2)

CCP:	ChcroMp15(nad2)

DHA:

ND2

LBG:	89432249(nad2)

CAL:	CaalfMp09(NAD2)

CLUS:

16792612(nad2)

YLI:	802601(nd2)

NCR:

NCU16006

PAN:	PoanfMp04(nad2)

CTHR:

CTHT_m000270

SSCK:

SPSK_11046

FGR:	GizefMp03(nad2)

PTKZ:

MRV25_mgp15(nad2)

VAL:	VDBG_17006

CLUP:

AYB75_mgp06(nad2)

SSL:	SS1G_20043

ANI:	ANID_20002

ANG:	Asnifp16(nad2)

ALUC:

EJ508_mgp02(nad2)

PNO:	SNOGp13(nad2)

BZE:	COCCADRAFT_113372

BOR:	COCMIDRAFT_111428

MRT:	D9L16_mgp15(nad2)

PSTR:

EFH26_mgp09(nad2)

DDI:	DidioMp03(nad2)

TET:	TepyoMp11(nad2)

PIF:	PITG_23229

PSOJ:

PhsooMp17(nad2)

MHEY:

H2LOC_010245

SRC:	M271_20175

» show all

Reference

PMID:9475751

Authors

Wise CA, Sraml M, Easteal S

Title

Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees.

Journal

Genetics 148:409-21 (1998)

Sequence

[hsa:4536]

LinkDB

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