KEGG   ORTHOLOGY: K04119
Entry
K04119                      KO                                     
Symbol
AKR1C3
Name
aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00790  Folate biosynthesis
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05208  Chemical carcinogenesis - reactive oxygen species
Module
M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Reaction
R01836  testosterone:NAD+ 17-oxidoreductase
R01838  testosterone:NADP+ 17-oxidoreductase
R02352  estradiol-17beta:NAD+ 17-oxidoreductase
R02353  estradiol-17beta:NADP+ 17-oxidoreductase
R02799  11-epi-prostaglandin F2alpha:NADP+ 11-oxidoreductase
R03406  androst-5-ene-3beta,17beta-diol:NAD+ oxidoreductase
R03407  androst-5-ene-3beta,17beta-diol:NADP+ oxidoreductase
R08955  3alpha,21-dihydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)
R08957  3alpha-hydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)
R08960  5alpha-pregnane-3alpha,20alpha-diol:NADP+ oxidoreductase (A-specific)
R11763  6-(1'-hydroxy-2'-oxopropyl)-tetrahydropterin:NADP+ oxidoreductase
R13039  
R13219  androstan-3alpha,17beta-diol:NADP+ 17-oxidoreductase
R13220  dihydrotestosterone:NADP+ 17-oxidoreductase
R13221  dihydrotestosterone:NAD+ 17-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
   00590 Arachidonic acid metabolism
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.188  prostaglandin-F synthase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
Other DBs
GO: 0030283 0047017 0047026
Genes
HSA: 340811(AKR1C8) 8644(AKR1C3)
PTR: 100612718(AKR1C3) 100612887 746545
PPS: 100971300 100986388(AKR1C3) 100987632 100988315
GGO: 101144878(AKR1C3) 101147265(AKR1C8) 101152195
PON: 100174617(AKR1C3) 100432652 100461633 100462259
PPYG: 129006137 129006869 129006873 129006874(AKR1C8)
NLE: 100593325 100604844 100606512
HMH: 116457717 116460197(AKR1C8)
SSYN: 129491831 129491837 129491838
MCC: 100430336 711440 722485 722496
MCF: 102116465 102142023(HSD17B5) 102143072(AKR1C8) 102144231
MTHB: 126963005 126963008 126963422
MNI: 105490778 105490780 105490783 105494391 112428206
CSAB: 103237812 103237813 103237816
CATY: 105587690 105597446 105597481
PANU: 100997485 101022585 101024707
TGE: 112631307 112631750
MLEU: 105532496 105535734 105535762
RRO: 104674747 104678924
RBB: 108521036 108532990
TFN: 117082052 117082118 117083437
PTEH: 111528130 111528985 113224919
CANG: 105521700 105521704
CJC: 100406962 100409025 100409384
SBQ: 101041594 101042225 101049957
CIMI: 108285106 108292323 108292357
ANAN: 105710839 105710887 105710891
CSYR: 103261879 103261880 103261882 103261883 103263298 103263300
MMUR: 105858219 105858220 105858221 105858224
LCAT: 123623042 123623043 123623044 123623047
ERUF: 138375334 138375336 138375337 138375338 138375390
PCOQ: 105826891 105826910 105826913
OGA: 100942491 100967071
MCAL: 110308148
MPAH: 110333839 110333848
RNO: 361267(Akr1c15)
MCOC: 116081731
ANU: 117713832
ASYL: 127664685
MUN: 110560700
CGE: 100768090 100768376
MAUA: 101841267
PROB: 127229800
PLEU: 114708096
PMAV: 102909418
MORG: 121432600 121432606 121432658 121432668
MFOT: 126501679 126501680 126501681 126506800
AAMP: 119816160 119816243 119826549
CNL: 130885465
NGI: 103725884 103725890 103725892 103746652
HGL: 101702106
CPOC: 100727454
CCAN: 109678869 109680334 109680990
DSP: 122113031
DMER: 138805664
PLOP: 125366785
NCAR: 124961142 124961655
OCU: 108176284
OPI: 101524567 101525842 101526664 101526901 101527313 101527569 101527977
OCZ: 121148047 121148048 121148053 121148054 121161958 121167473 121167481 121167486
TUP: 102478063 102478495 102491222 102491650
GVR: 103602898 103610229 103610426
CFA: 497070(AKR1C3)
CLUD: 112658979
VVP: 112933725
VLG: 121496638
NPO: 129514265
AML: 100483758
UMR: 103676234
UAH: 113241124
UAR: 123802294(AKR1C8)
ELK: 111158636
LLV: 125107753
MPUF: 101678776
MNP: 132020017
MLK: 131838054
NVS: 122891768(AKR1C4)
ORO: 101377633 101379669
EJU: 114217720
ZCA: 113921662
MLX: 118021623 118021905
MANO: 123842005 123842017
LWW: 102748666 102748964
FCA: 100510801(AKR1C3)
PYU: 121014878
PCOO: 112867557
PBG: 122473163
PVIV: 125169528
LRUF: 124502362
LGF: 123591606
AJU: 106988139
PTG: 102963188
PPAD: 109273789
PUC: 125918575
PLEZ: 122223817
HHV: 120237198
CCRU: 144226934
BTA: 100139386(20ALPHA-HSD) 112441538 112449293 132342088 132342107 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
BOM: 102269337 102271453 102271733 102272308 102272594 102272882 102273443
BIU: 109567627 109568074 109568076 109568077 109568079 109568080 109568087
BBUB: 102389138 102395293 102395635 102396460 102396772 102399119 102400645 102404780 102415234
BBIS: 104985980 104985985 104985990 104985991 104985992 104985994 104985995 104985998 104985999 104986133
CHX: 102176340 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498
OAS: 101107119 101107541 101109111 101109377 101110434 101110693 105614315 106990122 114108656
BTAX: 128058197 128058202 128058203 128058208 128058211 128058212 128058213 128058216
CSUM: 138091116 138091651 138091745 138091796 138091808 138091833 138091836 138091865 138091869
ODA: 120860627 120868601 120869467 120869469 120869471
CCAD: 122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512 122448583
MREE: 136157847 136157852 136157854 136157856 136157857 136159311 136159313 136159314 136159316 136159318
OVR: 110127514 110142553 110142554 110142557 110142558 110142563 139029592
MBEZ: 129547517 129555459 129559457 129559483 129559564 129559569 129559578 129559602 129559618 129559630 129559646
SSC: 654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
CFR: 102511678 116656624 116661570
CBAI: 105074137 105074417 105074427 105074728
CDK: 105104488 105104489 105105880
VPC: 102531609 102541232 102541486
BACU: 103002145 103003050
BMUS: 118891073 118891271
LVE: 103069218
OOR: 101273575 101281536
LALB: 132525824 132525832
GMF: 115842191 115842192
DDP: 132421005 132421006
DLE: 111170128 111170129
PCAD: 102978533
PSIU: 116748968 116749098
PPHC: 136118038 136119112
NASI: 112407550 112407551
ECB: 100057212 100070491 100070501 100070509 100070616 111771771 111771772
EPZ: 103541472 103541473 103542048 139080563
EAI: 106824650 106827241 106827468 106846832 106846833 106846834 123281999
MYB: 102254990 102255491
MYD: 102751586 102763642
MMYO: 118672630 118672665
MLF: 102421358 102428982
MDT: 132215226 132215243
MYUM: 138992421 138992439
PKL: 118702292 118702295
EFUS: 103300835 103300840
MNA: 107542430 107542432
DRO: 112321159 112323007
SHON: 118977133
AJM: 119057712
PDIC: 114492418
PHAS: 123824859 123831227(AKR1C8)
MMF: 118632067 118632135
PPAM: 129084610 129084627
HAI: 109378613
PALE: 102889546
PGIG: 120608988
PVP: 105299187
MJV: 108384939 108393830 108407235 108407237 108407238 140847881
TOD: 119244650 119245260
SARA: 101543981 101545704 101551007 101551999 101555320 101555749
SFUM: 130024001 130024071 130024072 130024073 130024074
SETR: 126013285
LAV: 100659630 100659914
TMU: 101342771 101360332
ETF: 101653259 101653576
DNM: 101428157 101433437
PBRV: 138165825
OAA: 100085065 100085983
PSS: 102446010 102446253 102446483
CIZ: 142007201
CMY: 102943008 102946053 119563672
CCAY: 125625831
LKP: 140906277
NDS: 141985386
DCC: 119843778 119849865
CPIC: 101940001 101940260 101940524
TST: 117882842
CABI: 116815619
MRV: 120395343 120395491 120395494 120395542
PVT: 110070400 110071420 110088827
PMUA: 114590236 114604979 114604980 114604981 114605230 114605592
PRAF: 128421905 128421906 128421907 128421908 128421909 128422029
ZVI: 118090693 118090694 118090915
GJA: 107108026
EMC: 129335705
XLA: 100049750(XB5895996.L) 108704368 379255(akr1c2.L) 379425(akr1c8p.S) 443571(akr1c3.L) 447277(akr1c1.L) 779224(akr1c2.S)
XTR: 100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 448368(akr1c8p) 734139 779627(akr1c3) 779650(akr1c2)
NPR: 108789947 108789948 108789949 108799287 108799288 108799289 108799290 108799291
RTEM: 120921832 120921837 120932840 120932841 120932844 120932845 120932846 120932847 120932848 120932850 120932852 120932853
ACAT: 141132848 141132849 141132850 141132853 141132854 141132855 141132856
PADS: 140323239 140323241 140323242 140323244 140323246 140324974 140324976
BBUF: 120986929 121003640 121003647 121005304 121005315 121005327 121005417
BGAR: 122926123 122926509 122926510 122926608 122926609 122926626 122926627 122928540 122928541 122928561
DTC: 141083283 141083284 141083285 141083286 141083287 141083290 141083294 141083296 141083297 141083298 141083300 141083311 141083702
HSQ: 130267626 130267627 130267628 130267629 130267632 130267633 130267634 130267638 130267640 130267641
PWL: 138287475 138288486
CPLA: 122559456
HOC: 132825023
SCAU: 119963304
PFLL: 139134268
PPYR: 116168970
DMK: 116918341
PMEO: 129593135
PVUL: 126823863 130010387
HASI: 137266197
PMAX: 117329343 117329344 117331065
AIRR: 138327949
YBA: 132545179 132545188 132560261
MCAF: 127727738
MMER: 123536211
 » show all
Reference
PMID:7650035
  Authors
Khanna M, Qin KN, Wang RW, Cheng KC
  Title
Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 270:20162-8 (1995)
DOI:10.1074/jbc.270.34.20162
  Sequence
[hsa:8644]
Reference
PMID:15087468
  Authors
Qiu W, Zhou M, Labrie F, Lin SX
  Title
Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.
  Journal
Mol Endocrinol 18:1798-807 (2004)
DOI:10.1210/me.2004-0032
Reference
PMID:14979715
  Authors
Komoto J, Yamada T, Watanabe K, Takusagawa F
  Title
Crystal structure of human prostaglandin F synthase (AKR1C3).
  Journal
Biochemistry 43:2188-98 (2004)
DOI:10.1021/bi036046x
Reference
PMID:11165022
  Authors
Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N
  Title
Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
  Journal
Mol Cell Endocrinol 171:137-49 (2001)
DOI:10.1016/S0303-7207(00)00426-3
Reference
PMID:20186052
  Authors
Penning TM
  Title
New frontiers in androgen biosynthesis and metabolism.
  Journal
Curr Opin Endocrinol Diabetes Obes 17:233-9 (2010)
DOI:10.1097/MED.0b013e3283381a31
Reference
PMID:24189185
  Authors
Rizner TL, Penning TM
  Title
Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.
  Journal
Steroids 79:49-63 (2014)
DOI:10.1016/j.steroids.2013.10.012
LinkDB

KEGG   ENZYME: 1.1.1.51
Entry
EC 1.1.1.51                 Enzyme                                 
Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
R01836 R01838;
(other) R02352 R02353 R03406 R03407 R09956 R09957 R13039 R13219 R13220 R13221
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3
K05296  3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 340811(AKR1C8) 8644(AKR1C3)
PTR: 100612718(AKR1C3) 100612887 746545
PPS: 100971300 100986388(AKR1C3) 100987632 100988315
GGO: 101144878(AKR1C3) 101147265(AKR1C8) 101152195
PON: 100174617(AKR1C3) 100432652 100461633 100462259
PPYG: 129006137 129006869 129006873 129006874(AKR1C8)
NLE: 100593325 100604844 100606512
HMH: 116457717 116460197(AKR1C8)
SSYN: 129491831 129491837 129491838
MCC: 100430336 711440 722485 722496
MCF: 102116465 102142023(HSD17B5) 102143072(AKR1C8) 102144231
MTHB: 126963005 126963008 126963422
MNI: 105490778 105490780 105490783 105494391 112428206
CSAB: 103237812 103237813 103237816
CATY: 105587690 105597446 105597481
PANU: 100997485 101022585 101024707
TGE: 112631307 112631750
MLEU: 105532496 105535734 105535762
RRO: 104674747 104678924
RBB: 108521036 108532990
TFN: 117082052 117082118 117083437
PTEH: 111528130 111528985 113224919
CANG: 105521700 105521704
CJC: 100406962 100409025 100409384
SBQ: 101041594 101042225 101049957
CIMI: 108285106 108292323 108292357
ANAN: 105710839 105710887 105710891
CSYR: 103261879 103261880 103261882 103261883 103263298 103263300
MMUR: 105858219 105858220 105858221 105858224
LCAT: 123623042 123623043 123623044 123623047
ERUF: 138375334 138375336 138375337 138375338 138375390
PCOQ: 105826891 105826910 105826913
OGA: 100942491 100967071
MCAL: 110308148
MPAH: 110333839 110333848
RNO: 361267(Akr1c15)
MCOC: 116081731
ANU: 117713832
ASYL: 127664685
MUN: 110560700
CGE: 100768090 100768376
MAUA: 101841267
PROB: 127229800
PLEU: 114708096
PMAV: 102909418
MORG: 121432600 121432606 121432658 121432668
MFOT: 126501679 126501680 126501681 126506800
AAMP: 119816160 119816243 119826549
CNL: 130885465
NGI: 103725884 103725890 103725892 103746652
HGL: 101702106
CPOC: 100727454
CCAN: 109678869 109680334 109680990
DSP: 122113031
DMER: 138805664
PLOP: 125366785
NCAR: 124961142 124961655
OCU: 108176284
OPI: 101524567 101525842 101526664 101526901 101527313 101527569 101527977
OCZ: 121148047 121148048 121148053 121148054 121161958 121167473 121167481 121167486
TUP: 102478063 102478495 102491222 102491650
GVR: 103602898 103610229 103610426
CFA: 497070(AKR1C3)
CLUD: 112658979
VVP: 112933725
VLG: 121496638
NPO: 129514265
AML: 100483758
UMR: 103676234
UAH: 113241124
UAR: 123802294(AKR1C8)
ELK: 111158636
LLV: 125107753
MPUF: 101678776
MNP: 132020017
MLK: 131838054
NVS: 122891768(AKR1C4)
ORO: 101377633 101379669
EJU: 114217720
ZCA: 113921662
MLX: 118021623 118021905
MANO: 123842005 123842017
LWW: 102748666 102748964
FCA: 100510801(AKR1C3)
PYU: 121014878
PCOO: 112867557
PBG: 122473163
PVIV: 125169528
LRUF: 124502362
LGF: 123591606
AJU: 106988139
PTG: 102963188
PPAD: 109273789
PUC: 125918575
PLEZ: 122223817
HHV: 120237198
CCRU: 144226934
BTA: 100139386(20ALPHA-HSD) 112441538 112449293 132342088 132342107 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
BOM: 102269337 102271453 102271733 102272308 102272594 102272882 102273443
BIU: 109567627 109568074 109568076 109568077 109568079 109568080 109568087
BBUB: 102389138 102395293 102395635 102396460 102396772 102399119 102400645 102404780 102415234
BBIS: 104985980 104985985 104985990 104985991 104985992 104985994 104985995 104985998 104985999 104986133
CHX: 102176340 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498
OAS: 101107119 101107541 101109111 101109377 101110434 101110693 105614315 106990122 114108656
BTAX: 128058197 128058202 128058203 128058208 128058211 128058212 128058213 128058216
CSUM: 138091116 138091651 138091745 138091796 138091808 138091833 138091836 138091865 138091869
ODA: 120860627 120868601 120869467 120869469 120869471
CCAD: 122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512 122448583
MREE: 136157847 136157852 136157854 136157856 136157857 136159311 136159313 136159314 136159316 136159318
OVR: 110127514 110142553 110142554 110142557 110142558 110142563 139029592
MBEZ: 129547517 129555459 129559457 129559483 129559564 129559569 129559578 129559602 129559618 129559630 129559646
SSC: 654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
CFR: 102511678 116656624 116661570
CBAI: 105074137 105074417 105074427 105074728
CDK: 105104488 105104489 105105880
VPC: 102531609 102541232 102541486
BACU: 103002145 103003050
BMUS: 118891073 118891271
LVE: 103069218
OOR: 101273575 101281536
LALB: 132525824 132525832
GMF: 115842191 115842192
DDP: 132421005 132421006
DLE: 111170128 111170129
PCAD: 102978533
PSIU: 116748968 116749098
PPHC: 136118038 136119112
NASI: 112407550 112407551
ECB: 100057212 100070491 100070501 100070509 100070616 111771771 111771772
EPZ: 103541472 103541473 103542048 139080563
EAI: 106824650 106827241 106827468 106846832 106846833 106846834 123281999
MYB: 102254990 102255491
MYD: 102751586 102763642
MMYO: 118672630 118672665
MLF: 102421358 102428982
MDT: 132215226 132215243
MYUM: 138992421 138992439
PKL: 118702292 118702295
EFUS: 103300835 103300840
MNA: 107542430 107542432
DRO: 112321159 112323007
SHON: 118977133
AJM: 119057712
PDIC: 114492418
PHAS: 123824859 123831227(AKR1C8)
MMF: 118632067 118632135
PPAM: 129084610 129084627
HAI: 109378613
PALE: 102889546
PGIG: 120608988
PVP: 105299187
MJV: 108384939 108393830 108407235 108407237 108407238 140847881
TOD: 119244650 119245260
SARA: 101543981 101545704 101551007 101551999 101555320 101555749
SFUM: 130024001 130024071 130024072 130024073 130024074
SETR: 126013285
LAV: 100659630 100659914
TMU: 101342771 101360332
ETF: 101653259 101653576
DNM: 101428157 101433437
PBRV: 138165825
OAA: 100085065 100085983
PSS: 102446010 102446253 102446483
CIZ: 142007201
CMY: 102943008 102946053 119563672
CCAY: 125625831
LKP: 140906277
NDS: 141985386
DCC: 119843778 119849865
CPIC: 101940001 101940260 101940524
TST: 117882842
CABI: 116815619
MRV: 120395343 120395491 120395494 120395542
PVT: 110070400 110071420 110088827
PMUA: 114590236 114604979 114604980 114604981 114605230 114605592
PRAF: 128421905 128421906 128421907 128421908 128421909 128422029
ZVI: 118090693 118090694 118090915
GJA: 107108026
EMC: 129335705
XLA: 100049750(XB5895996.L) 108704368 379255(akr1c2.L) 379425(akr1c8p.S) 443571(akr1c3.L) 447277(akr1c1.L) 779224(akr1c2.S)
XTR: 100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 448368(akr1c8p) 734139 779627(akr1c3) 779650(akr1c2)
NPR: 108789947 108789948 108789949 108799287 108799288 108799289 108799290 108799291
RTEM: 120921832 120921837 120932840 120932841 120932844 120932845 120932846 120932847 120932848 120932850 120932852 120932853
ACAT: 141132848 141132849 141132850 141132853 141132854 141132855 141132856
PADS: 140323239 140323241 140323242 140323244 140323246 140324974 140324976
BBUF: 120986929 121003640 121003647 121005304 121005315 121005327 121005417
BGAR: 122926123 122926509 122926510 122926608 122926609 122926626 122926627 122928540 122928541 122928561
DTC: 141083283 141083284 141083285 141083286 141083287 141083290 141083294 141083296 141083297 141083298 141083300 141083311 141083702
HSQ: 130267626 130267627 130267628 130267629 130267632 130267633 130267634 130267638 130267640 130267641
PWL: 138287475 138288486
CPLA: 122559456
HOC: 132825023
SCAU: 119963304
PFLL: 139134268
PPYR: 116168970
DMK: 116918341
PMEO: 129593135
PVUL: 126823863 130010387
HASI: 137266197
PMAX: 117329343 117329344 117331065
AIRR: 138327949
YBA: 132545179 132545188 132560261
MCAF: 127727738
MMER: 123536211
RGL: CS053_01735
PRE: PCA10_43660
PFUW: KF707C_11730 KF707C_11870
PLAL: FXN65_05815 FXN65_21130
PPUU: PputUW4_01679
PKC: PKB_4320
PFZ: AV641_10575
PPSY: AOC04_07875
PSET: THL1_4408
PSIL: PMA3_11580
PKE: DLD99_14670
PUM: HGP31_20975
PPSH: G5J76_13530
PAZE: KSS91_19200
PTAE: NCTC10697_02065
PCAV: D3880_17455
PPHN: HU825_14715
PIZ: LAB08_R40780
PSHS: JJN09_05505
PLAU: I0D68_06085
PSKP: KU43P_19170
PDEU: QEP73_14435
PBUB: V6B39_16865
PSMZ: V6L79_14250
PSWO: SD196_12730
PMOR: PMm318_A52470
PSAO: SK095_03135 SK095_03760
SDEG: GOM96_01720
HARR: HV822_17940
PPHA: BVH74_17925
HASM: QAO71_12395
SHL: Shal_2144
SNAN: I6N98_05660
ZAL: AZF00_07095
OSG: BST96_18245
MAGA: Mag101_11180
PAQM: E0F26_07275
MSEC: LN244_04840
MRZ: KDW95_00835
EMP: EZMO1_1333(hsd)
SOK: D0B54_05265
SINI: GT972_08470
FCE: JN531_005460
RIN: ACS15_4335 ACS15_4391
REH: H16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNC: CNE_2c05880 CNE_2c05960
CUH: BJN34_30930
REU: Reut_A1545 Reut_A1552
CTI: RALTA_B0491
CBW: RR42_s2341
COX: E0W60_08155 E0W60_08190
CUK: KB879_20650 KB879_20685
CUPP: CTP10_R38730 CTP10_R38800
CUPA: LPA45_24025 LPA45_24060
BUR: Bcep18194_B1514
BCT: GEM_4149
BCEP: APZ15_31395
BPYR: ABD05_28030
BCON: NL30_04370
BDF: WI26_20980
BTEI: WS51_05535
BSTL: BBJ41_21110
BANN: JFN94_25445
BARI: NLX30_30410
BAEN: L3V59_21505
BURK: DM992_32810
BURF: Bsp3421_002169
BFN: OI25_4612
PBRY: NDK50_32995
PPAI: E1956_37105
PVE: UC34_06900
CABA: SBC2_48780
BOJ: CBF45_04255
CTT: CtCNB1_1764
CTES: O987_11065
CRJ: QMY55_09630
DIH: G7047_10950
SMIO: CATMQ487_31550(fabG3)
DOE: DENOEST_3109
DENI: B9N43_09200
AZI: AzCIB_1461
AZD: CDA09_09700
THU: AC731_008840
THAU: C4PIVTH_4327
THAG: CKCBHOJB_02373
MESJ: MJ8_05730
MEWS: QAZ47_01370
MIV: C4E04_06100
METG: HT051_00245
CBOT: ATE48_13085
NAR: Saro_3532 Saro_3545
NPP: PP1Y_AT9316 PP1Y_Mpl5490
NRE: BES08_24625
NOV: TQ38_017245 TQ38_022035
NGF: FRF71_08380
NHUM: PQ457_21665
NOL: NSDW_20670 NSDW_26920
NCP: U0041_19785
NOVO: IM701_16270 IM701_17260
SPHJ: BSL82_07570 BSL82_07605 BSL82_14320
SWI: Swit_2259
SPHD: HY78_14230
SPMI: K663_17776 K663_18116
SPHR: BSY17_3924
SHYD: CJD35_06880
SBAR: H5V43_14105
SPPH: KFK14_08000 KFK14_08870 KFK14_21620
SPHG: AZE99_02190 AZE99_02220 AZE99_05050
SFLA: SPHFLASMR4Y_01334(benD) SPHFLASMR4Y_01377(benD) SPHFLASMR4Y_01932(benD) SPHFLASMR4Y_01938(benD)
SPHY: CHN51_03345 CHN51_03375 CHN51_18065
PARJ: J4G78_04415 J4G78_13315 J4G78_13345
PHAO: HF685_13350 HF685_13380 HF685_15840
ALH: G6N82_09490
ALTC: P7228_00950 P7228_00960
CMAN: A9D14_16350 A9D14_16785
ELQ: Ga0102493_111118
PNS: A9D12_03500
ERYT: KDC96_13840
ERQ: PS060_04580
PORL: BG023_11268
PHZ: CHX26_01065 CHX26_01075
POT: E2E27_02035
PORC: CBR61_00710
NTD: EGO55_06220 EGO55_06680 EGO55_06825
GDI: GDI2584
GDJ: Gdia_0818
GXY: GLX_27910
GXL: H845_832
KNA: B0W47_14495
KEU: S101446_03159
KSC: CD178_00217(cpnA_1)
KRE: GWK63_04970
KOI: LV478_10085
KSU: ACM0P6_13910
ASZ: ASN_3327
ATO: CIW82_14800
KHA: IFJ82_02365
NCB: C0V82_25770
GME: Gmet_2217
MSD: MYSTI_00848
MFB: MFUL124B02_04805
MLAN: JY572_22295
CEXI: ACN6A2_13600
 » show all
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe Seylers Z Physiol Chem 336:63-8 (1964)
DOI:10.1515/bchm2.1964.336.1.63
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J Biol Chem 232:1015-30 (1958)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J Biol Chem 252:3775-83 (1977)
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J Biol Chem 205:823-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.51
IUBMB Enzyme Nomenclature: 1.1.1.51
ExPASy - ENZYME nomenclature database: 1.1.1.51
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.51
BRENDA, the Enzyme Database: 1.1.1.51
CAS: 9015-81-0
LinkDB

KEGG   REACTION: R13039
Entry
R13039                      Reaction                               
Definition
Androstan-3alpha,17beta-diol + NAD+ <=> Androsterone + NADH + H+
Equation
C03852 + C00003 <=> C00523 + C00004 + C00080
Comment
hydroxysteroid 17beta dehydrogenase
Reaction class
RC00127  C00523_C03852
Enzyme
1.1.1.51        1.1.1.-
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51
     R13039  Androstan-3alpha,17beta-diol + NAD+ <=> Androsterone + NADH + H+
    1.1.1.-
     R13039  Androstan-3alpha,17beta-diol + NAD+ <=> Androsterone + NADH + H+
Orthology
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K25779  hydroxysteroid 17beta dehydrogenase 11 [EC:1.1.1.-]
Reference
1  [PMID:12697717]
  Authors
Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z
  Title
17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.
  Journal
Endocrinology 144:2084-91 (2003)
DOI:10.1210/en.2002-221030
Reference
2  [PMID:10800688]
  Authors
Haeseleer F, Palczewski K.
  Title
Short-chain dehydrogenases/reductases in retina.
  Journal
Methods Enzymol 316:372-83 (2000)
LinkDB

KEGG   REACTION: R13219
Entry
R13219                      Reaction                               
Name
androstan-3alpha,17beta-diol:NADP+ 17-oxidoreductase
Definition
Androsterone + NADPH + H+ <=> Androstan-3alpha,17beta-diol + NADP+
Equation
C00523 + C00005 + C00080 <=> C03852 + C00006
Reaction class
RC00127  C00523_C03852
Enzyme
1.1.1.51        1.1.1.64
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51
     R13219  Androsterone + NADPH + H+ <=> Androstan-3alpha,17beta-diol + NADP+
    1.1.1.64
     R13219  Androsterone + NADPH + H+ <=> Androstan-3alpha,17beta-diol + NADP+
Orthology
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K10207  testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64]
LinkDB

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