KEGG   ORTHOLOGY: K04126
Entry
K04126                      KO                                     
Symbol
PCBC
Name
isopenicillin-N synthase [EC:1.21.3.1]
Pathway
map00311  Penicillin and cephalosporin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00672  Penicillin biosynthesis, aminoadipate + cycteine + valine => penicillin
M00673  Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C
Reaction
R04872  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K04126  PCBC; isopenicillin-N synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K04126  PCBC; isopenicillin-N synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.21  Catalysing the reaction X-H + Y-H = X-Y
   1.21.3  With oxygen as acceptor
    1.21.3.1  isopenicillin-N synthase
     K04126  PCBC; isopenicillin-N synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Nonribosomal peptide tailoring proteins
  Others
   K04126  PCBC; isopenicillin-N synthase
Other DBs
GO: 0016216
Genes
BCOO: 119077147
FCD: 110843583
PMEO: 129593743
PCHM: VFPPC_08656
ANI: ANIA_02622
AOR: AO090038000544
AFV: AFLA_009030
APUU: APUU_12363A
PCS: N7525_006405
ABE: ARB_02225
TVE: TRV_00552
XRY: QN244_11745
SCLF: BB341_07795
STIR: DDW44_23090
SCT: SCAT_5683(pcbC)
SCY: SCATT_56830
AAB: A4R43_03225
AMYY: YIM_39180(cefE1)
PSUU: Psuf_059690
 » show all
Reference
PMID:7791906
  Authors
Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE
  Title
Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
  Journal
Nature 375:700-4 (1995)
DOI:10.1038/375700a0
  Sequence
[ani:ANIA_02622]
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