ORTHOLOGY: K04346
Help
Entry
K04346 KO
Symbol
GNA12
Name
guanine nucleotide-binding protein subunit alpha-12
Pathway
map04010
MAPK signaling pathway
map04022
cGMP-PKG signaling pathway
map04071
Sphingolipid signaling pathway
map04072
Phospholipase D signaling pathway
map04270
Vascular smooth muscle contraction
map04361
Axon regeneration
map04730
Long-term depression
map04810
Regulation of actin cytoskeleton
map04928
Parathyroid hormone synthesis, secretion and action
map05130
Pathogenic Escherichia coli infection
map05163
Human cytomegalovirus infection
map05200
Pathways in cancer
Disease
H02434
Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
04072 Phospholipase D signaling pathway
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
04071 Sphingolipid signaling pathway
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
04022 cGMP-PKG signaling pathway
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09153 Circulatory system
04270 Vascular smooth muscle contraction
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09156 Nervous system
04730 Long-term depression
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09158 Development and regeneration
04361 Axon regeneration
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
04031 GTP-binding proteins
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:
ko04147
]
Exosomal proteins
Exosomal proteins of hepatic cells
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:
ko04031
]
Heterotrimeric G-proteins
Alpha Subunits
Alpha type 4 (G12/13)
K04346 GNA12; guanine nucleotide-binding protein subunit alpha-12
BRITE hierarchy
Genes
HSA:
2768
(GNA12)
PTR:
463234
(GNA12)
PPS:
100979605
(GNA12)
GGO:
101147243
(GNA12)
PPYG:
129040269
(GNA12)
NLE:
100591916
(GNA12)
HMH:
116810819
(GNA12)
SSYN:
129489505
(GNA12)
MCC:
100429106
(GNA12)
MCF:
101867258
(GNA12)
MTHB:
126951492
MNI:
105483392
(GNA12)
CSAB:
103246857
(GNA12)
CATY:
105571739
(GNA12)
PANU:
101015317
(GNA12)
TGE:
112620279
(GNA12)
MLEU:
105537343
(GNA12)
RRO:
104664964
(GNA12)
RBB:
108543875
(GNA12)
TFN:
117073210
(GNA12)
PTEH:
111523703
(GNA12)
CANG:
105522441
(GNA12)
105522480
CJC:
100387912
(GNA12)
SBQ:
101042405
(GNA12)
CIMI:
108308110
(GNA12)
ANAN:
105719502
(GNA12)
CSYR:
103254023
(GNA12)
MMUR:
105868406
(GNA12)
LCAT:
123631510
(GNA12)
PCOQ:
105806081
(GNA12)
OGA:
100956403
(GNA12)
MMU:
14673
(Gna12)
MCAL:
110295092
(Gna12)
MPAH:
110312844
(Gna12)
RNO:
81663
(Gna12)
MCOC:
116068678
(Gna12)
ANU:
117698098
(Gna12)
MUN:
110554732
(Gna12)
CGE:
100760944
(Gna12)
MAUA:
101824460
(Gna12)
PROB:
127237273
(Gna12)
PLEU:
114705518
(Gna12)
MORG:
121445951
121464859
MFOT:
126514346
AAMP:
119825531
(Gna12)
NGI:
103748670
(Gna12)
HGL:
101697421
(Gna12)
CPOC:
100726202
(Gna12)
CCAN:
109683409
(Gna12)
DORD:
105990866
(Gna12)
DSP:
122113573
(Gna12)
PLOP:
125339093
(Gna12)
NCAR:
124970276
MMMA:
107155972
OCU:
100347293
OPI:
101525794
(GNA12)
TUP:
102501406
(GNA12)
GVR:
103585712
(GNA12)
CFA:
102154318
(GNA12)
CLUD:
112640210
(GNA12)
VVP:
112929357
(GNA12)
VLG:
121487216
(GNA12)
NPO:
129519699
(GNA12)
AML:
100465369
(GNA12)
UMR:
103669942
(GNA12)
UAH:
113267979
(GNA12)
UAR:
123802492
(GNA12)
ELK:
111146098
LLV:
125090604
MPUF:
101677577
(GNA12)
MNP:
132026441
(GNA12)
MLK:
131819299
(GNA12)
NVS:
122896083
(GNA12)
ORO:
101371250
(GNA12)
EJU:
114199958
(GNA12)
ZCA:
113933210
(GNA12)
MLX:
117999301
(GNA12)
NSU:
110571937
(GNA12)
LWW:
102735043
(GNA12)
FCA:
101093316
(GNA12)
PYU:
121017425
(GNA12)
PBG:
122471226
(GNA12)
PVIV:
125154113
(GNA12)
LRUF:
124519214
PTG:
102961052
(GNA12)
PPAD:
109251142
(GNA12)
PUC:
125928430
AJU:
106984497
HHV:
120228022
(GNA12)
BTA:
515159
(GNA12)
BOM:
102265273
(GNA12)
BIU:
109578204
(GNA12)
BBUB:
102409709
(GNA12)
BBIS:
105002254
(GNA12)
CHX:
102185175
(GNA12)
OAS:
101111070
(GNA12)
BTAX:
128064366
(GNA12)
ODA:
120882944
(GNA12)
CCAD:
122432743
(GNA12)
MBEZ:
129545783
(GNA12)
SSC:
100525156
(GNA12)
CFR:
102524525
(GNA12)
116666290
CBAI:
105067606
105078210
(GNA12)
CDK:
105086681
(GNA12)
VPC:
102536014
(GNA12)
BACU:
103009974
(GNA12)
BMUS:
118880853
(GNA12)
LVE:
103069136
(GNA12)
OOR:
101281075
(GNA12)
DLE:
111169388
(GNA12)
PSIU:
116739840
(GNA12)
NASI:
112412027
(GNA12)
ECB:
100060005
(GNA12)
EPZ:
103549418
(GNA12)
EAI:
106834780
(GNA12)
MYB:
102260289
(GNA12)
MYD:
102763801
(GNA12)
MMYO:
118657873
(GNA12)
MDT:
132236042
(GNA12)
PKL:
118711380
(GNA12)
EFUS:
103299196
(GNA12)
MNA:
107541162
(GNA12)
DRO:
112319524
(GNA12)
SHON:
118995031
(GNA12)
AJM:
119037188
119043796
(GNA12)
PDIC:
114509149
(GNA12)
PHAS:
123809602
(GNA12)
MMF:
118616426
(GNA12)
PPAM:
129069895
(GNA12)
HAI:
109380223
(GNA12)
RFQ:
117016789
(GNA12)
PALE:
102891706
(GNA12)
PGIG:
120615752
(GNA12)
PVP:
105294560
(GNA12)
RAY:
107521430
(GNA12)
MJV:
108383439
(GNA12)
TOD:
119241629
(GNA12)
SARA:
101539799
(GNA12)
SETR:
126030440
(GNA12)
LAV:
100676444
(GNA12)
TMU:
101351796
ETF:
101637962
(GNA12)
DNM:
101425884
(GNA12)
MDO:
100010453
(GNA12)
GAS:
123233988
(GNA12)
SHR:
100916443
(GNA12)
AFZ:
127563717
PCW:
110200100
(GNA12)
TVP:
118855030
(GNA12)
OAA:
100082592
(GNA12)
GGA:
769924
(GNA12)
PCOC:
116237643
(GNA12)
MGP:
100550659
(GNA12)
CJO:
107320696
(GNA12)
TPAI:
128078993
(GNA12)
LMUT:
125700551
(GNA12)
NMEL:
110405782
(GNA12)
APLA:
101798445
(GNA12)
ACYG:
106032065
(GNA12)
CATA:
118249105
(GNA12)
AFUL:
116495096
(GNA12)
TGU:
100225137
(GNA12)
LSR:
110480984
(GNA12)
SCAN:
103817628
(GNA12)
PMOA:
120513017
(GNA12)
OTC:
121334382
(GNA12)
PRUF:
121350703
(GNA12)
GFR:
102044790
(GNA12)
FAB:
101818259
(GNA12)
OMA:
130259123
(GNA12)
PHI:
102104762
(GNA12)
PMAJ:
107211274
(GNA12)
CCAE:
111936095
(GNA12)
CCW:
104684810
(GNA12)
CBRC:
103615421
(GNA12)
ETL:
114060163
(GNA12)
ZAB:
102061493
(GNA12)
ZLE:
135453945
(GNA12)
ACHL:
103805475
(GNA12)
SVG:
106849684
(GNA12)
MMEA:
130575727
(GNA12)
HRT:
120759457
(GNA12)
SATI:
136367913
(GNA12)
FPG:
101917262
(GNA12)
FCH:
102059010
(GNA12)
CCRI:
104161739
(GNA12)
NNT:
104404855
(GNA12)
SHAB:
115607349
(GNA12)
ACUN:
113485647
(GNA12)
TALA:
104365124
(GNA12)
ACHC:
115335761
(GNA12)
HALD:
104321090
(GNA12)
HLE:
104833566
(GNA12)
AGEN:
126034026
GCL:
127022239
CSTI:
104556093
(GNA12)
LDI:
104348690
(GNA12)
MNB:
103776247
(GNA12)
DPUB:
104297114
(GNA12)
AVIT:
104269513
(GNA12)
BRHI:
104491840
(GNA12)
EGZ:
104132621
(GNA12)
NNI:
104015218
(GNA12)
PCRI:
104037638
(GNA12)
PCAO:
104043924
(GNA12)
PADL:
103913532
(GNA12)
AFOR:
103904872
(GNA12)
FGA:
104071699
(GNA12)
GSTE:
104265046
(GNA12)
CLV:
102088372
(GNA12)
MUI:
104538606
(GNA12)
PGUU:
104470588
(GNA12)
PLET:
104623881
(GNA12)
EHS:
104516171
(GNA12)
CMAC:
104475831
(GNA12)
CUCA:
104059213
(GNA12)
TEO:
104371953
(GNA12)
BREG:
104642082
(GNA12)
OHA:
104331208
(GNA12)
ACAR:
104531429
(GNA12)
CPEA:
104385246
(GNA12)
CVF:
104287699
(GNA12)
RTD:
128913572
(GNA12)
AAM:
106483939
(GNA12)
AROW:
112974274
(GNA12)
NPD:
112960066
(GNA12)
TGT:
104571605
(GNA12)
DNE:
112992860
(GNA12)
SCAM:
104153963
(GNA12)
ASN:
102377286
(GNA12)
AMJ:
102559993
(GNA12)
CPOO:
109314716
(GNA12)
GGN:
109294314
(GNA12)
PSS:
102445616
(GNA12)
CMY:
102931254
(GNA12)
CCAY:
125643747
(GNA12)
DCC:
119862577
(GNA12)
CPIC:
101947834
(GNA12)
TST:
117884213
(GNA12)
CABI:
116816726
(GNA12)
MRV:
120373445
(GNA12)
ACS:
100564021
(gna12)
ASAO:
132782165
(GNA12)
PVT:
110083721
(GNA12)
SUND:
121914259
(GNA12)
PBI:
103050241
(GNA12)
PMUR:
107290610
(GNA12)
CTIG:
120315644
(GNA12)
TSR:
106543761
(GNA12)
PGUT:
117659919
(GNA12)
APRI:
131185123
(GNA12)
PTEX:
113438808
(GNA12)
NSS:
113423705
(GNA12)
VKO:
123025206
(GNA12)
PMUA:
114584033
(GNA12)
PRAF:
128401334
(GNA12)
ZVI:
118092639
(GNA12)
HCG:
128336449
(GNA12)
GJA:
107116703
(GNA12)
STOW:
125431108
(GNA12)
EMC:
129338685
(GNA12)
MUO:
115476043
(GNA12)
GSH:
117369354
(GNA12)
DRE:
503589
(gna12a)
SRX:
107753491
107758336
SANH:
107674729
107703403
SGH:
107581709
(gna12)
107592501
CCAR:
109088191
109113757
CAUA:
113050125
113079568
113088985
113092116
CGIB:
127952148
127953545
PTET:
122341311
(gna12a)
LROH:
127160470
(gna12a)
OMC:
131537052
(gna12a)
PPRM:
120489108
(gna12a)
RKG:
130095021
(gna12a)
MAMB:
125269719
(gna12a)
CIDE:
127509296
CERY:
137017790
(gna12a)
MASI:
127443584
127443861
127445556
127450194
127452347
TROS:
130561712
(gna12a)
TDW:
130425677
(gna12a)
MANU:
129432518
(gna12a)
129444883
129444884
129444885
IPU:
108257129
(gna12a)
IFU:
128600128
(gna12a)
PHYP:
113536042
(gna12)
SMEO:
124375972
(gna12a)
TFD:
113660383
(gna12a)
TVC:
132863941
(gna12a)
TRN:
134306869
(gna12a)
AMEX:
103024018
(gna12a)
CMAO:
118805729
(gna12a)
EEE:
113581016
(gna12)
CHAR:
105890330
105890719
(gna12a)
TRU:
101078184
(gna12)
TFS:
130528018
(gna12a)
TNG:
GSTEN00015763G001
LCO:
104929956
(gna12)
NCC:
104953227
(gna12)
TBEN:
117481651
(gna12a)
CGOB:
115008038
(gna12)
PGEO:
117448073
(gna12a)
GACU:
117556119
(gna12a)
EMAC:
134865114
(gna12a)
ELY:
117255443
(gna12a)
EFO:
125885556
(gna12a)
PLEP:
121941718
(gna12a)
SLUC:
116042660
(gna12a)
ECRA:
117957719
(gna12a)
ESP:
116705828
(gna12)
PFLV:
114568096
(gna12)
GAT:
120825079
(gna12a)
PPUG:
119217467
(gna12a)
AFB:
129095527
(gna12a)
CLUM:
117737754
(gna12a)
PSWI:
130189521
(gna12a)
MSAM:
119898751
(gna12a)
119898752
SCHU:
122874052
(gna12a)
CUD:
121508158
(gna12a)
ALAT:
119019371
(gna12a)
MZE:
101473086
(gna12)
ONL:
100695956
(gna12)
OAU:
116312366
(gna12a)
OLA:
101166935
(gna12)
OML:
112137476
(gna12a)
CSAI:
133441845
(gna12a)
XMA:
102222306
(gna12)
XCO:
114145506
(gna12)
XHE:
116720292
(gna12)
PRET:
103462653
(gna12)
PFOR:
107834460
GAF:
122829843
(gna12a)
PPRL:
129353743
(gna12a)
CVG:
107086421
(gna12)
CTUL:
119783694
(gna12a)
GMU:
124868741
(gna12a)
NFU:
107388805
(gna12)
KMR:
108231102
(gna12a)
ALIM:
106519647
(gna12)
106535814
NWH:
119422367
(gna12a)
AOCE:
111579495
(gna12)
MCEP:
125004095
(gna12a)
CSEM:
103383240
(gna12)
POV:
109639272
(gna12)
SSEN:
122771451
(gna12a)
HHIP:
117767462
(gna12a)
HSP:
118123197
(gna12a)
PPLT:
128435359
(gna12a)
SMAU:
118312928
(gna12a)
LCF:
108888452
(gna12a)
SDU:
111216573
(gna12)
SLAL:
111663289
(gna12)
XGL:
120800111
(gna12a)
HCQ:
109511425
(gna12)
SSCV:
125969295
SBIA:
133506237
(gna12a)
PEE:
133403577
(gna12a)
PTAO:
133477245
(gna12a)
BPEC:
110153513
(gna12)
MALB:
109968205
(gna12)
BSPL:
114858608
(gna12a)
SJO:
128380053
(gna12a)
SASA:
106593532
STRU:
115177669
115181662
OTW:
112239603
OMY:
110513250
110519706
(gna12a)
OGO:
124003139
(gna12a)
124024495
124029096
OKI:
109885709
(gna12)
OKE:
127921912
SNH:
120035391
(gna12a)
CCLU:
121534255
(gna12a)
ELS:
105006302
(gna12)
SFM:
108927048
(gna12)
PKI:
111845481
111853263
AANG:
118217277
(gna12a)
118221254
LOC:
102693638
(gna12)
PSPA:
121300879
121331272
ARUT:
117418024
117431230
PSEX:
120541896
(gna12a)
LCM:
102367557
(GNA12)
CMK:
103185131
(gna12a)
RTP:
109917843
(gna12a)
109931104
CPLA:
122542251
122560793
(gna12a)
HOC:
132825238
(gna12a)
132831524
LERI:
129706639
(gna12a)
SPU:
414055
AJC:
117122316
SKO:
100371005
DME:
Dmel_CG17678
(cta)
DER:
6548622
DSE:
6620479
DSI:
Dsimw501_GD17672
(Dsim_GD17672)
DYA:
Dyak_GE22695
(Dyak_cta)
DAN:
6498720
DSR:
110188780
DPO:
6902762
DPE:
6597992
DMN:
108163668
DWI:
6642655
DGR:
6566635
DMO:
Dmoj_GI10235
DAZ:
108610046
DNV:
108649870
DHE:
111594096
DVI:
6633906
CCAT:
101452736
BOD:
106616482
BDR:
105223724
RZE:
108371791
AOQ:
129248317
TDA:
119688960
MDE:
101898580
SCAC:
106088831
LCQ:
111688751
LSQ:
119603833
GFS:
119640398
ECOE:
129940632
CLON:
129615055
HIS:
119652244
AGA:
1269257
ACOZ:
120955650
AARA:
120901285
AMER:
121596778
121602548
ASTE:
118510753
AFUN:
125763500
AMOU:
128305938
AALI:
118461840
AAG:
5570853
AALB:
109429571
115262082
115262090
ASUA:
134213687
CQU:
CpipJ_CPIJ001150
CPII:
120425173
CNS:
116338299
BCOO:
119066084
AME:
410906
ACER:
108001125
ALAB:
122720258
ADR:
102672251
AFLR:
100870055
BIM:
100745931
BBIF:
117210671
BVK:
117237546
BVAN:
117164145
BTER:
100649951
BAFF:
126916231
BPYO:
122565611
BPAS:
132904833
FVI:
122528975
CCAL:
108622504
OBB:
114871357
OLG:
117605366
MGEN:
117220251
NMEA:
116435250
CGIG:
122400909
SOC:
105200292
MPHA:
105839168
AEC:
105147295
ACEP:
105624301
PBAR:
105431792
VEM:
105569521
HST:
105181192
DQU:
106742960
CFO:
105259283
FEX:
115234956
LHU:
105675078
(cta)
PGC:
109863777
OBO:
105278292
PCF:
106784198
PFUC:
122520237
VPS:
122635570
VCRB:
124428856
VVE:
124955600
NVI:
100115318
CSOL:
105359649
TPRE:
106654846
LHT:
122499998
LBD:
127278961
MDL:
103572197
CGLO:
123266192
FAS:
105272862
DAM:
107041977
AGIF:
122857141
CINS:
118068529
VCAN:
122408770
CCIN:
107267537
DSM:
124410307
124412685
NPT:
124220614
124221057
NFB:
124181951
124185784
NLO:
107221508
107224562
NVG:
124306360
124308049
AROA:
105682890
105689986
TCA:
661072
DPA:
109541992
SOY:
115891177
AGRG:
126746121
ATD:
109601983
CSET:
123313468
AGB:
108913892
LDC:
111509125
DVV:
114329636
NVL:
108559178
108565189
APLN:
108732666
PPYR:
116175451
OTU:
111420380
BMOR:
100862775
(Galpha12)
BMAN:
114248860
MSEX:
115443118
DPL:
KGM_209650
BANY:
112043613
MJU:
123878954
NIQ:
126770207
VCD:
124533617
MCIX:
123653411
PMAC:
106720633
PPOT:
106109104
PXU:
106127207
PRAP:
111001958
PBX:
123719946
PNAP:
125054295
ZCE:
119834786
CCRC:
123690873
LSIN:
126974870
AAGE:
121731821
HAW:
110369680
HZE:
124631128
TNL:
113491781
SLIU:
111351563
OFU:
114362424
ATRA:
106138779
GMW:
113517536
PXY:
105391521
PGW:
126367553
LGLY:
125227935
CFEL:
113365753
113368159
CCRN:
123294620
API:
100165181
DNX:
107169778
AGS:
114131159
RMD:
113552929
ACOO:
126838339
DVT:
126900305
BTAB:
109044576
DCI:
103507297
CLEC:
106672229
HHAL:
106681511
(cta)
NLU:
111051510
HVI:
124367594
MQU:
128991671
PHU:
Phum_PHUM222390
FOC:
113216054
TPAL:
117644422
ZNE:
110838798
CSEC:
111865428
SGRE:
126354411
BROR:
134532492
IEL:
124169086
FCD:
110848091
DPX:
DAPPUDRAFT_190301
(Gna12)
DMK:
116919473
DPZ:
124343288
PVM:
113811454
PJA:
122244302
PCHN:
125047461
PMOO:
119596372
HAME:
121869372
PCLA:
123770742
CQD:
128690446
PTRU:
123498692
ESN:
127002009
MNZ:
135222679
HAZT:
108671428
EAF:
111712669
LSM:
121117819
TCF:
131880588
DSV:
119453135
RSAN:
119399997
RMP:
119180408
TUT:
107368817
CSCU:
111616767
111627514
CVS:
136984147
136989625
(cta)
PTEP:
107444621
107449780
ABRU:
129969629
129984273
UDV:
129225762
129227764
SDM:
118181202
118186749
CEL:
CELE_F18G5.3
(gpa-12)
CBR:
CBG_16182
(Cbr-gpa-12)
CRQ:
GCK72_023268
NAI:
NECAME_09853
BMY:
BM_BM3442
(Bma-gpa-12)
LOA:
LOAG_11957
TSP:
Tsp_00479
HRO:
HELRODRAFT_110990
HELRODRAFT_96238
LGI:
LOTGIDRAFT_137888
PVUL:
126811803
PCAN:
112573964
BGT:
106078602
GAE:
121380023
HRF:
124150876
HRJ:
124266840
CRG:
105341702
CANU:
128166198
CVN:
111120036
OED:
125669821
MYI:
110465109
PMAX:
117325622
MCAF:
127708701
RPHI:
132744004
DPOL:
127866199
MAEA:
128245807
LJP:
135471162
LAK:
106174984
LLON:
135496089
NVE:
5520204
EPA:
110251752
ATEN:
116298423
ADF:
107350389
AMIL:
114947132
PDAM:
113680345
SPIS:
111329690
DGT:
114529102
XEN:
124447715
124448767
HMG:
100192290
HSY:
130648869
TAD:
TRIADDRAFT_49927
» show all
Taxonomy
UniProt
Reference
PMID:
8423800
Authors
Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA
Title
Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
Journal
Mol Cell Biol 13:762-8 (1993)
DOI:
10.1128/MCB.13.2.762
Sequence
[hsa:
2768
]
Reference
PMID:
22609986
Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
Journal
Nat Cell Biol 14:686-96 (2012)
DOI:
10.1038/ncb2507
Sequence
[hsa:
2768
]
LinkDB
All DBs
ORTHOLOGY: K04639
Help
Entry
K04639 KO
Symbol
GNA13
Name
guanine nucleotide-binding protein subunit alpha-13
Pathway
map04022
cGMP-PKG signaling pathway
map04071
Sphingolipid signaling pathway
map04072
Phospholipase D signaling pathway
map04270
Vascular smooth muscle contraction
map04371
Apelin signaling pathway
map04611
Platelet activation
map04730
Long-term depression
map04810
Regulation of actin cytoskeleton
map04928
Parathyroid hormone synthesis, secretion and action
map05130
Pathogenic Escherichia coli infection
map05163
Human cytomegalovirus infection
map05200
Pathways in cancer
Disease
H02434
Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
04072 Phospholipase D signaling pathway
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
04071 Sphingolipid signaling pathway
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
04022 cGMP-PKG signaling pathway
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09153 Circulatory system
04270 Vascular smooth muscle contraction
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09156 Nervous system
04730 Long-term depression
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
04031 GTP-binding proteins
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
Exosome [BR:
ko04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
Exosomal proteins of colorectal cancer cells
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
GTP-binding proteins [BR:
ko04031
]
Heterotrimeric G-proteins
Alpha Subunits
Alpha type 4 (G12/13)
K04639 GNA13; guanine nucleotide-binding protein subunit alpha-13
BRITE hierarchy
Genes
HSA:
10672
(GNA13)
PTR:
454827
(GNA13)
PPS:
100988877
(GNA13)
GGO:
101152866
(GNA13)
PON:
100461065
(GNA13)
PPYG:
129017194
(GNA13)
NLE:
100589821
(GNA13)
HMH:
116458484
(GNA13)
SSYN:
129469826
(GNA13)
MCC:
718144
(GNA13)
MCF:
102127819
(GNA13)
MTHB:
126938356
MNI:
105469013
(GNA13)
CSAB:
103243186
(GNA13)
CATY:
105573047
(GNA13)
PANU:
101010815
(GNA13)
TGE:
112609527
(GNA13)
MLEU:
105532531
(GNA13)
RRO:
104675436
(GNA13)
RBB:
108517753
(GNA13)
TFN:
117067409
(GNA13)
PTEH:
111542515
(GNA13)
CANG:
105508914
(GNA13)
CJC:
100394016
(GNA13)
SBQ:
101034540
(GNA13)
CIMI:
108281659
(GNA13)
ANAN:
105718196
(GNA13)
CSYR:
103260636
(GNA13)
MMUR:
105861706
(GNA13)
LCAT:
123650582
(GNA13)
PCOQ:
105824802
(GNA13)
OGA:
100963709
(GNA13)
MMU:
14674
(Gna13)
MCAL:
110304818
(Gna13)
MPAH:
110331761
(Gna13)
RNO:
303634
(Gna13)
MCOC:
116076843
(Gna13)
ANU:
117711084
(Gna13)
MUN:
110560037
(Gna13)
CGE:
100689071
(Gna13)
MAUA:
101835577
(Gna13)
PROB:
127218636
(Gna13)
PLEU:
114690445
(Gna13)
MORG:
121436098
(Gna13)
MFOT:
126514965
AAMP:
119812989
(Gna13)
NGI:
103742208
(Gna13)
HGL:
101719378
(Gna13)
CPOC:
100730887
(Gna13)
CCAN:
109696711
(Gna13)
DORD:
106003117
(Gna13)
DSP:
122128327
(Gna13)
PLOP:
125365237
(Gna13)
NCAR:
124973058
124979863
MMMA:
107158364
(Gna13)
OCU:
100352794
OPI:
101522146
(GNA13)
TUP:
102488219
(GNA13)
GVR:
103587812
(GNA13)
CFA:
490901
(GNA13)
CLUD:
112652903
(GNA13)
VVP:
112920734
(GNA13)
VLG:
121473119
(GNA13)
NPO:
129510400
(GNA13)
AML:
100474482
(GNA13)
UMR:
103665670
(GNA13)
UAH:
113265242
(GNA13)
UAR:
123802930
(GNA13)
ELK:
111158131
LLV:
125087041
MPUF:
101676878
(GNA13)
MNP:
132004175
(GNA13)
MLK:
131815704
(GNA13)
NVS:
122906056
(GNA13)
ORO:
101386508
(GNA13)
EJU:
114216074
(GNA13)
ZCA:
113939205
(GNA13)
MLX:
118024340
(GNA13)
NSU:
110570477
(GNA13)
LWW:
102751138
FCA:
101087625
(GNA13)
PYU:
121015328
(GNA13)
PCOO:
112864473
(GNA13)
PBG:
122485811
(GNA13)
PVIV:
125151400
(GNA13)
LRUF:
124513497
PTG:
102964498
(GNA13)
PPAD:
109277047
(GNA13)
PUC:
125927373
AJU:
106975340
HHV:
120230247
(GNA13)
BTA:
505611
(GNA13)
BOM:
102275435
(GNA13)
BIU:
109573379
(GNA13)
BBUB:
102390212
(GNA13)
BBIS:
105000283
(GNA13)
CHX:
102170818
(GNA13)
OAS:
101117003
(GNA13)
BTAX:
128064617
(GNA13)
ODA:
120866595
(GNA13)
CCAD:
122426182
(GNA13)
MBEZ:
129544787
(GNA13)
SSC:
100522824
(GNA13)
CFR:
102523556
(GNA13)
CBAI:
105063934
(GNA13)
CDK:
105085708
(GNA13)
VPC:
102542921
(GNA13)
BACU:
103007094
(GNA13)
BMUS:
118886324
(GNA13)
LVE:
103071564
(GNA13)
OOR:
101277931
(GNA13)
DLE:
111182908
(GNA13)
PCAD:
102989616
(GNA13)
PSIU:
116745371
(GNA13)
NASI:
112410234
(GNA13)
ECB:
100062972
(GNA13)
EPZ:
103553497
(GNA13)
EAI:
106835353
(GNA13)
MYB:
102252423
(GNA13)
MYD:
102764420
(GNA13)
MMYO:
118671564
(GNA13)
MLF:
102436989
(GNA13)
MDT:
132218615
(GNA13)
PKL:
118726223
(GNA13)
EFUS:
103293115
(GNA13)
MNA:
107538305
(GNA13)
DRO:
112316266
(GNA13)
SHON:
119003776
(GNA13)
AJM:
119036264
(GNA13)
PDIC:
114502354
(GNA13)
PHAS:
123816761
(GNA13)
MMF:
118633864
(GNA13)
PPAM:
129070232
(GNA13)
HAI:
109380315
(GNA13)
RFQ:
117013275
(GNA13)
PALE:
102891607
(GNA13)
PGIG:
120599999
(GNA13)
PVP:
105297699
(GNA13)
RAY:
107510298
(GNA13)
MJV:
108392407
(GNA13)
TOD:
119233057
(GNA13)
SARA:
101539190
(GNA13)
SETR:
126018343
(GNA13)
LAV:
100664965
(GNA13)
TMU:
101346987
ETF:
101645418
(GNA13)
DNM:
101414963
(GNA13)
MDO:
100024566
(GNA13)
GAS:
123247196
(GNA13)
SHR:
100932191
(GNA13)
AFZ:
127560565
PCW:
110218195
(GNA13)
TVP:
118846154
(GNA13)
OAA:
103166871
(GNA13)
GGA:
417434
(GNA13)
PCOC:
116232471
(GNA13)
MGP:
100540964
(GNA13)
CJO:
107322109
(GNA13)
TPAI:
128083115
(GNA13)
LMUT:
125702156
(GNA13)
NMEL:
110407202
(GNA13)
APLA:
101801355
(GNA13)
ACYG:
106034698
(GNA13)
CATA:
118253924
(GNA13)
AFUL:
116496726
(GNA13)
TGU:
100223985
(GNA13)
LSR:
110473974
(GNA13)
SCAN:
103819970
(GNA13)
PMOA:
120505454
(GNA13)
OTC:
121338294
(GNA13)
PRUF:
121363416
(GNA13)
GFR:
102040291
(GNA13)
FAB:
101812192
(GNA13)
OMA:
130260494
(GNA13)
PHI:
102099584
(GNA13)
PMAJ:
107212551
(GNA13)
CCAE:
111937573
(GNA13)
CCW:
104696029
(GNA13)
CBRC:
103620076
(GNA13)
ETL:
114060688
(GNA13)
ZAB:
102072742
(GNA13)
ZLE:
135455311
(GNA13)
ACHL:
103797437
(GNA13)
SVG:
106856973
(GNA13)
MMEA:
130586259
(GNA13)
HRT:
120760940
(GNA13)
SATI:
136369477
(GNA13)
FPG:
101922831
(GNA13)
FCH:
102052233
(GNA13)
CCRI:
104156397
(GNA13)
NNT:
104406093
(GNA13)
SHAB:
115616828
(GNA13)
ACUN:
113486831
(GNA13)
TALA:
104364962
(GNA13)
ACHC:
115341158
(GNA13)
HALD:
104314263
(GNA13)
HLE:
104838711
(GNA13)
AGEN:
126043580
GCL:
127023973
CSTI:
104556662
(GNA13)
LDI:
104342392
(GNA13)
MNB:
103781356
(GNA13)
DPUB:
104302182
(GNA13)
AVIT:
104277477
(GNA13)
BRHI:
104502367
(GNA13)
EGZ:
104132822
(GNA13)
NNI:
104014357
(GNA13)
PCRI:
104030963
(GNA13)
PCAO:
104043920
(GNA13)
PADL:
103916715
(GNA13)
AFOR:
103902427
(GNA13)
FGA:
104070701
(GNA13)
GSTE:
104258907
(GNA13)
CLV:
102084052
(GNA13)
MUI:
104547727
(GNA13)
PGUU:
104467650
(GNA13)
PLET:
104619761
(GNA13)
EHS:
104508909
(GNA13)
CMAC:
104476698
(GNA13)
CUCA:
104061899
(GNA13)
TEO:
104374740
(GNA13)
BREG:
104639304
(GNA13)
OHA:
104329923
(GNA13)
ACAR:
104523460
(GNA13)
CPEA:
104393316
(GNA13)
CVF:
104295068
(GNA13)
RTD:
128917876
(GNA13)
AAM:
106493143
(GNA13)
AROW:
112966899
(GNA13)
NPD:
112953660
(GNA13)
TGT:
104565219
(GNA13)
DNE:
112982543
(GNA13)
SCAM:
104146776
(GNA13)
ASN:
102376261
(GNA13)
AMJ:
102568562
(GNA13)
CPOO:
109314956
(GNA13)
GGN:
109296855
(GNA13)
PSS:
102458860
(GNA13)
CMY:
102940587
(GNA13)
CCAY:
125621745
(GNA13)
DCC:
119842627
(GNA13)
CPIC:
101953084
(GNA13)
TST:
117887642
(GNA13)
CABI:
116822478
(GNA13)
MRV:
120383144
(GNA13)
ACS:
100554119
(gna13)
ASAO:
132767758
(GNA13)
PVT:
110085885
(GNA13)
SUND:
121921524
(GNA13)
PBI:
103050681
(GNA13)
PMUR:
107282571
(GNA13)
CTIG:
120300037
(GNA13)
TSR:
106553054
(GNA13)
PGUT:
117662931
(GNA13)
APRI:
131189902
(GNA13)
PTEX:
113443166
(GNA13)
NSS:
113419429
(GNA13)
VKO:
123033089
(GNA13)
PMUA:
114588210
(GNA13)
PRAF:
128407252
(GNA13)
ZVI:
118079645
(GNA13)
HCG:
128343341
(GNA13)
GJA:
107105951
(GNA13)
STOW:
125428521
(GNA13)
EMC:
129327370
(GNA13)
XLA:
108701204
(gna13.L)
496349
(gna13.S)
XTR:
100145489
(gna13)
NPR:
108802992
(GNA13)
RTEM:
120919355
(GNA13)
BBUF:
121003271
(GNA13)
BGAR:
122923241
(GNA13)
MUO:
115473477
(GNA13)
GSH:
117367864
(GNA13)
DRE:
326825
(gna13a)
336333
(gna13b)
SRX:
107709641
107719992
107721501
107734232
SANH:
107654495
107660858
107688114
107692049
SGH:
107554062
107584085
107590387
107601276
CCAR:
109049849
109049931
109100123
109109108
CAUA:
113056064
113081926
113098973
113112106
CGIB:
127951169
127952108
127969155
128025210
128030253
PTET:
122339221
(gna13b)
122355266
(gna13a)
LROH:
127158773
(gna13b)
127174542
(gna13a)
OMC:
131536152
(gna13b)
131551427
(gna13a)
PPRM:
120464018
120489648
(gna13b)
RKG:
130075835
(gna13b)
130088630
(gna13a)
MAMB:
125255403
(gna13a)
125271647
(gna13b)
CIDE:
127509439
127523407
CERY:
137007889
(gna13a)
137017705
(gna13b)
MASI:
127423674
127427249
127450851
127451758
TROS:
130561398
(gna13b)
130568723
(gna13a)
TDW:
130425758
(gna13b)
130438916
(gna13a)
MANU:
129420380
129420410
129420411
129421149
129433978
(gna13b)
IPU:
108273768
(gna13a)
108278714
(gna13b)
IFU:
128617557
(gna13a)
128622253
(gna13b)
PHYP:
113527443
113528528
SMEO:
124388927
(gna13a)
124396690
(gna13b)
TFD:
113637145
(gna13a)
113659226
(gna13b)
TVC:
132838846
(gna13a)
132860607
(gna13b)
TRN:
134321382
(gna13a)
134335866
(gna13b)
AMEX:
103022306
(gna13a)
103046194
(gna13b)
CMAO:
118809485
(gna13a)
118821059
(gna13b)
EEE:
113574856
113580257
CHAR:
105888894
(gna13a)
105899987
(gna13b)
TRU:
101065558
101071876
TFS:
130514840
(gna13b)
130530704
TNG:
GSTEN00010504G001
GSTEN00027029G001
LCO:
104923415
104927178
NCC:
104946516
TBEN:
117469241
(gna13b)
117473605
CGOB:
115012229
115025027
PGEO:
117451038
(gna13b)
117464507
GACU:
117544552
117551504
EMAC:
134870300
134877977
(gna13b)
ELY:
117247232
117268272
(gna13b)
EFO:
125878913
(gna13b)
125880536
PLEP:
121957290
(gna13b)
121958546
SLUC:
116045102
(gna13b)
116061103
ECRA:
117937186
117958637
(gna13b)
ESP:
116671786
116702591
PFLV:
114547969
114569558
GAT:
120819191
120827658
(gna13b)
PPUG:
119212736
119220611
(gna13b)
AFB:
129091104
129098123
(gna13b)
CLUM:
117734523
(gna13b)
117749238
PSWI:
130188346
(gna13b)
130203241
MSAM:
119915709
119918667
(gna13b)
SCHU:
122867246
122869561
(gna13b)
CUD:
121528175
121529287
(gna13b)
ALAT:
119009746
119013756
(gna13b)
MZE:
101466738
101472915
ONL:
100701321
100712037
OAU:
116325955
116332737
(gna13b)
OLA:
101159749
101162018
101175626
OML:
112154003
112157938
(gna13b)
CSAI:
133419600
133422790
(gna13b)
XMA:
102222912
102227062
(gna13)
XCO:
114148609
114151980
(gna13)
XHE:
116726921
(gna13)
116735936
PRET:
103468273
103481631
PFOR:
103149245
103151262
PLAI:
106939093
106952122
PMEI:
106905790
106928955
GAF:
122821330
(gna13b)
122822843
PPRL:
129363206
(gna13b)
129368295
CVG:
107100329
107102520
CTUL:
119771741
119778522
GMU:
124862732
124864591
124875331
NFU:
107387703
107391564
KMR:
108228367
108248446
ALIM:
106519019
106530025
NWH:
119421454
(gna13b)
119424061
AOCE:
111567436
111586729
MCEP:
124998048
(gna13b)
CSEM:
103381794
103393488
POV:
109640373
109642241
SSEN:
122759349
122785486
HHIP:
117753076
117765823
(gna13b)
HSP:
118100669
118122986
(gna13b)
PPLT:
128426825
128458016
(gna13b)
SMAU:
118288004
118288516
(gna13b)
LCF:
108876453
108898004
(gna13b)
SDU:
111219813
111236257
SLAL:
111667200
111673547
XGL:
120794244
120806440
(gna13b)
HCQ:
109508599
109516320
SSCV:
125983964
125991759
SBIA:
133495659
133515144
(gna13b)
PEE:
133414353
(gna13b)
133417741
PTAO:
133466394
(gna13b)
133469564
BPEC:
110164386
(gna13)
MALB:
109964702
109967924
BSPL:
114845814
114860741
(gna13b)
SJO:
128378260
(gna13b)
128380975
SASA:
106589443
106594878
106606258
STRU:
115156644
115171929
115201224
115208564
OTW:
112223394
112224319
112224721
OMY:
100305179
110485327
110491343
118938365
OGO:
124020574
124040078
124048122
ONE:
115106329
115144100
OKI:
109865520
109870070
109876168
109886145
OKE:
118357427
118368606
118382664
SALP:
111967821
SNH:
120029965
120042580
120046110
CCLU:
121547385
121551455
121569987
121584357
ELS:
105012792
105026577
SFM:
108937123
108940086
PKI:
111848291
111856756
(gna13)
AANG:
118216503
(gna13b)
118219543
LOC:
102687288
(gna13)
PSPA:
121295594
121296219
ARUT:
117423695
117424191
PSEX:
120517146
(gna13b)
LCM:
102364864
(GNA13)
CMK:
103175515
(gna13a)
RTP:
109931209
(gna13a)
CPLA:
122562184
HOC:
132828016
(gna13a)
LERI:
129708281
(gna13a)
PMRN:
116946263
116949541
LRJ:
133346399
133353421
133353633
BBEL:
109483923
CIN:
100180076
SCLV:
120333469
SPU:
115918012
LPIC:
129270362
APLC:
110980280
ARUN:
117293013
117293032
PPOI:
119095636
VDE:
111250444
VJA:
111272399
DFR:
124496032
LPOL:
106463454
106470070
106478447
PMEO:
129591599
CBR:
CBG_15067
PCAN:
112567820
OSN:
115216703
OVI:
T265_10834
RES:
135692287
AQU:
105312217
» show all
Taxonomy
UniProt
Reference
PMID:
2508088
Authors
Strathmann M, Wilkie TM, Simon MI
Title
Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.
Journal
Proc Natl Acad Sci U S A 86:7407-9 (1989)
DOI:
10.1073/pnas.86.19.7407
Reference
PMID:
7791744
Authors
Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD
Title
Expression of GTP-binding protein alpha subunits in human thymocytes.
Journal
Mol Cell Biochem 144:45-51 (1995)
DOI:
10.1007/bf00926739
Sequence
[hsa:
10672
]
LinkDB
All DBs
DBGET
integrated database retrieval system