KEGG ORTHOLOGY: K04361

ORTHOLOGY: K04361

Entry

K04361                      KO

Symbol

EGFR, ERBB1

Name

epidermal growth factor receptor [EC:2.7.10.1]

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map03272

Virion - Hepatitis viruses

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04013

MAPK signaling pathway - fly

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04072

Phospholipase D signaling pathway

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04214

Apoptosis - fly

map04320

Dorso-ventral axis formation

map04510

Focal adhesion

map04520

Adherens junction

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map04912

GnRH signaling pathway

map04915

Estrogen signaling pathway

map04921

Oxytocin signaling pathway

map04926

Relaxin signaling pathway

map04928

Parathyroid hormone synthesis, secretion and action

map04934

Cushing syndrome

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05131

Shigellosis

map05160

Hepatitis C

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05219

Bladder cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05230

Central carbon metabolism in cancer

map05231

Choline metabolism in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Disease

H00014

Non-small cell lung cancer

H00016

Oral cancer

H00017

Esophageal cancer

H00022

Bladder cancer

H00028

Choriocarcinoma

H00030

Cervical cancer

H00031

Breast cancer

H00042

Glioma

H00055

Laryngeal cancer

H01508

Salivary gland cancer

H01559

Oropharyngeal cancer

H02467

Neonatal inflammatory skin and bowel disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03272 Virion - Hepatitis viruses
    K04361  EGFR, ERBB1; epidermal growth factor receptor
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 JAK-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04928 Parathyroid hormone synthesis, secretion and action
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05207 Chemical carcinogenesis - receptor activation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05208 Chemical carcinogenesis - reactive oxygen species
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05226 Gastric cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05171 Coronavirus disease - COVID-19
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05163 Human cytomegalovirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05131 Shigellosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor

Other DBs

GO:

0005006

Genes

HSA:	1956(EGFR)

PTR:	463415(EGFR)

PPS:	100974885(EGFR)

GGO:	101126190(EGFR)

PON:	100459280(EGFR)

PPYG:

129040324(EGFR)

NLE:	100597255(EGFR)

HMH:	116812436(EGFR)

SSYN:

129489915(EGFR)

MCC:	613027(EGFR)

MCF:	102138724(EGFR)

MTHB:

126950202

MNI:	105493061(EGFR)

CSAB:

103226055(EGFR)

CATY:

105588269(EGFR)

PANU:

101003588(EGFR)

TGE:	112620091(EGFR)

MLEU:

105529594(EGFR)

RRO:	104675886(EGFR)

RBB:	108522039(EGFR)

TFN:	117073506(EGFR)

PTEH:

111555709(EGFR)

CANG:

105500265(EGFR)

CJC:	100412158(EGFR)

SBQ:	101047461(EGFR)

CIMI:

108294535(EGFR)

ANAN:

105721853(EGFR) 135271862

CSYR:

103268107(EGFR)

MMUR:

105877217(EGFR)

LCAT:

123647442(EGFR)

ERUF:

138377172(EGFR)

PCOQ:

105813943(EGFR)

OGA:	100950302(EGFR)

MMU:	13649(Egfr)

MCAL:

110304228(Egfr)

MPAH:

110330480(Egfr)

RNO:	24329(Egfr)

MCOC:

116071392(Egfr)

ANU:	117712744(Egfr)

ASYL:

127696026(Egfr)

MUN:	110539539(Egfr)

CGE:	100774580(Egfr)

MAUA:

101838749(Egfr)

PROB:

127233970(Egfr)

PLEU:

114705532(Egfr)

PMAV:

102910428(Egfr)

MORG:

121459895(Egfr)

MFOT:

126500934

AAMP:

119812357(Egfr)

CNL:	130875410(Egfr)

NGI:

103748852

HGL:	101723771(Egfr)

CPOC:

100725363(Egfr)

CCAN:

109693753(Egfr)

DORD:

106000675(Egfr)

DSP:	122112209(Egfr)

DMER:

138809444(Egfr)

PLOP:

125346757(Egfr)

NCAR:

124990601

MMMA:

107146095(Egfr)

ITI:	101961479(Egfr)

OCU:

100008806

OCZ:	121145630(EGFR)

TUP:	102485304(EGFR)

GVR:	103595295(EGFR) 103604776

CFA:	404306(EGFR)

CLUD:

112661500

VVP:	112925820(EGFR)

VLG:	121471236(EGFR)

NPO:	129494118(EGFR)

UMR:	103674660(EGFR)

UAH:	113257444(EGFR)

UAR:	123786270(EGFR)

ELK:

111157042

LLV:

125080419

MPUF:

101685824(EGFR)

MNP:	132016105(EGFR)

MLK:	131829150(EGFR)

NVS:	122904647(EGFR)

ORO:	101386858(EGFR)

EJU:	114213645(EGFR)

ZCA:	113911010(EGFR)

MLX:	118024535(EGFR)

NSU:	110592687(EGFR)

FCA:	100510799(EGFR)

PYU:	121017018(EGFR)

PCOO:

112860068(EGFR)

PBG:	122487677(EGFR)

PVIV:

125160878(EGFR)

LRUF:

124523868

LGF:	123606208(EGFR)

AJU:

106976977

PTG:	102967370(EGFR)

PPAD:

109267979(EGFR)

PUC:

125929783

PLEZ:

122205603(EGFR)

HHV:	120238884(EGFR)

BTA:	407217(EGFR)

BOM:	102269868(EGFR)

BIU:	109576048(EGFR)

BBUB:

102398103(EGFR)

BKE:	129634993(EGFR)

BBIS:

104990172(EGFR)

CHX:	102172767(EGFR)

OAS:	780479(EGFR)

BTAX:

128051614(EGFR)

CSUM:

138087135(EGFR)

ODA:	120867903(EGFR)

CCAD:

122424243(EGFR)

MREE:

136166522(EGFR)

OVR:	110135620(EGFR)

MBEZ:

129548207(EGFR)

SSC:	397070(EGFR)

CFR:	102504272(EGFR)

CBAI:

105067674(EGFR)

CDK:	105105749(EGFR)

VPC:	102538051(EGFR)

BACU:

103017029(EGFR)

BMUS:

118900495(EGFR)

LVE:	103071962(EGFR)

OOR:	101275398(EGFR)

LALB:

132524903(EGFR)

GMF:	115860975(EGFR)

DDP:	132430855(EGFR)

DLE:	111184548(EGFR)

PCAD:

102975467(EGFR)

PSIU:

116759758(EGFR)

PPHC:

136127833(EGFR)

NASI:

112412693(EGFR)

ECB:	100067755(EGFR)

EPZ:	103560128(EGFR)

EAI:	106824133(EGFR)

MYB:	102257758(EGFR)

MYD:	102775204(EGFR)

MMYO:

118665909(EGFR)

MLF:	102435209(EGFR)

MDT:	132211195(EGFR)

MYUM:

139016584(EGFR)

PKL:	118727800(EGFR)

EFUS:

103294241(EGFR)

MNA:	107525996(EGFR)

DRO:	112306912(EGFR)

SHON:

118983507(EGFR)

AJM:	119057339(EGFR)

PDIC:

114507607(EGFR)

PHAS:

123811124(EGFR)

MMF:	118620077(EGFR)

PPAM:

129068919(EGFR)

HAI:	109388365(EGFR)

RFQ:	117012187(EGFR)

PALE:

102893495(EGFR)

PGIG:

120602477(EGFR)

PVP:

105306141

RAY:	107498193(EGFR)

MJV:	108397962(EGFR)

TOD:	119231744(EGFR)

SARA:

101552863(EGFR)

SFUM:

130045209(EGFR)

SETR:

126013961(EGFR)

LAV:	100659125(EGFR)

TMU:

101356822

ETF:	101652848(EGFR)

DNM:	105746538(EGFR)

MDO:	100029625(EGFR)

GAS:	123247456(EGFR)

SHR:	100914017(EGFR)

AFZ:

127553324

PCW:	110204990(EGFR)

TVP:	118831942(EGFR)

PBRV:

138157940(EGFR)

MLAO:

141496130(EGFR)

OAA:	100075894(EGFR)

TACU:

119940123(EGFR)

GGA:	396494(EGFR)

PCOC:

116232773(EGFR)

MGP:	100543252(EGFR)

CJO:	107309802(EGFR)

TPAI:

128088438(EGFR)

LMUT:

125696492(EGFR)

NMEL:

110393050(EGFR)

APLA:

101797830(EGFR)

AACU:

137852769(EGFR)

ACYG:

106046417(EGFR)

CATA:

118250916(EGFR)

AFUL:

116485864(EGFR)

TGU:	100221035(EGFR)

LSR:	110471171(EGFR)

SCAN:

103819418(EGFR)

PMOA:

120505010(EGFR)

OTC:	121346981(EGFR)

PRUF:

121352949(EGFR)

ATRC:

139591276(EGFR)

GFR:	102045482(EGFR)

FAB:	101818290(EGFR)

OMA:	130248937(EGFR)

PHI:	102101445(EGFR)

PMAJ:

107200328(EGFR)

CCAE:

111923657(EGFR)

CCW:	104689262(EGFR)

CBRC:

103615833(EGFR)

ACOE:

138106691(EGFR)

ETL:	114057239(EGFR)

ZAB:	102066957(EGFR)

ZLE:	135443993(EGFR)

SVG:	106860008(EGFR)

MMEA:

130573114(EGFR)

HRT:	120750050(EGFR)

SATI:

136363444(EGFR)

CFAI:

136293693(EGFR)

CCIC:

134046925(EGFR)

FPG:	101910521(EGFR)

FCH:	102058683(EGFR)

CCRI:

104165764(EGFR)

SHAB:

115604109(EGFR)

ACUN:

113477535(EGFR)

SURA:

141953266(EGFR)

TALA:

104366457(EGFR)

ACHC:

115338920(EGFR)

HALD:

104314842(EGFR)

HLE:	104840682(EGFR)

AGEN:

126045454

HHAR:

128145437(EGFR)

BBUT:

142043448(EGFR)

GCL:

127029897

LDI:	104345569(EGFR)

MNB:	103773796(EGFR)

DPUB:

104298303(EGFR)

PPUS:

135189326(EGFR)

AVIT:

104276524(EGFR)

BRHI:

104489782(EGFR)

EGZ:	104131586(EGFR)

NNI:	104012443(EGFR)

PCRI:

104033436

PCAO:

104047900(EGFR)

PADL:

103914859(EGFR)

AFOR:

103895453(EGFR)

FGA:	104079920(EGFR)

CBOR:

142079187(EGFR)

GSTE:

104254604(EGFR)

CBOY:

140648055(EGFR)

MAME:

142405753(EGFR)

CLV:	102097879(EGFR)

CNIC:

135986269(EGFR)

MUI:	104540611(EGFR)

PGUU:

104464895(EGFR)

PLET:

104616401(EGFR)

EHS:	104510253(EGFR)

CUCA:

104065959(EGFR)

TEO:	104379087(EGFR)

BREG:

104638183(EGFR)

GAME:

129202464(EGFR)

OHA:	104337164(EGFR)

ACAR:

104524553(EGFR)

CPEA:

104393487(EGFR)

CVF:	104290342(EGFR)

RTD:	128904866(EGFR)

CRID:

134511534(EGFR)

LMIC:

141739079(EGFR)

NARQ:

141463851(EGFR)

AAM:	106495273(EGFR)

AROW:

112970678(EGFR)

NPD:	112945566(EGFR)

TGT:	104568591(EGFR)

DNE:	112996092(EGFR)

SCAM:

104147043(EGFR)

ASN:	102378285(EGFR)

AMJ:	102565209(EGFR)

CPOO:

109312928(EGFR)

GGN:	109291886(EGFR)

PSS:	102443405(EGFR)

CIZ:	142009679(EGFR)

CMY:	102933326(EGFR)

CCAY:

125631817(EGFR)

LKP:	140907268(EGFR)

NDS:	141982850(EGFR)

DCC:	119851699(EGFR)

CPIC:

101952725(EGFR)

TST:	117872619(EGFR)

CABI:

116832636(EGFR)

MRV:	120397061(EGFR)

ACS:	100562231(egfr)

ASAO:

132778525(EGFR)

PVT:	110081594(EGFR)

SUND:

121935547(EGFR)

PBI:	103050691(EGFR)

PMUR:

107284695(EGFR)

CTIG:

120305219(EGFR)

TSR:	106539158(EGFR)

PGUT:

117664986(EGFR)

APRI:

131198824(EGFR)

PTEX:

113437354(EGFR)

NSS:	113422095(EGFR)

VKO:	123023248(EGFR)

PMUA:

114607096(EGFR)

PRAF:

128424163(EGFR)

ZVI:	118077665(EGFR)

HCG:	128329427(EGFR)

GJA:	107119225(EGFR)

STOW:

125440695(EGFR)

EMC:	129338046(EGFR)

XLA:	108719997(egfr.S) 724072(egfr.L)

XTR:	100492965(egfr)

NPR:	108799381 108799518

RTEM:

120940364(EGFR)

ACAT:

141144607

PADS:

140331320(EGFR)

BBUF:

121002062(EGFR)

BGAR:

122939241(EGFR)

DTC:	141052749(EGFR)

PWL:	138261925(EGFR)

MUO:	115470537(EGFR) 115479211

GSH:	117353859(EGFR)

DRE:	101884366 378478(egfra) 571431

SRX:	107708546 107731792 107732093 107747514

SANH:

107677280 107681784 107690979 107691124

SGH:	107554803 107566457 107599721

CCAR:

109046603 109050338 109079006 109095046

CAUA:

113042612 113045981 113092711 113114389

CGIB:

127946419 127951006 128013286 128022357

PTET:

122325042 122329898 122360456(egfra)

LROH:

127156110 127176285(egfra)

GRF:	141300780 141344900(egfra)

OMC:	131523087(egfra) 131533491

PPRM:

120463339 120488261

RKG:	130084114 130097444 130097620(egfra)

MAMB:

125250587(egfra) 125257816

CIDE:

127505760 127506254

CERY:

137003636(egfra) 137013462

MASI:

127434636 127441072 127442004

TROS:

130546779 130554082(egfra)

TDW:	130412958 130417299(egfra)

MANU:

129426034 129442582(egfra)

PDAB:

135740335 135750874(egfra)

IPU:	108280575(egfra)

IFU:	128624292(egfra)

PHYP:

113546391(egfr)

SMEO:

124403152(egfra)

TFD:	113655514(egfra)

TVC:	132844608(egfra)

CGAR:

128512858(egfra)

NGRA:

132871853(egfra)

TRN:	134302846(egfra)

AMEX:

103031629(egfra) 103032492

CMAO:

118796721(egfra) 118823220

EEE:	113587946 113590490(egfr)

CHAR:

105896901 105900501(egfra)

SPIL:

134066455 134073125(egfra)

ASAD:

121688530 121715361(egfra)

TRU:	101069322(egfr) 101073748

TFS:	130513758 130539496(egfra)

TNG:	GSTEN00025328G001 GSTEN00025331G001 GSTEN00027642G001

LCO:	104917709 104937534

TBEN:

117486666 117488453(egfra)

CGOB:

115022485

PGEO:

117462222(egfra)

GACU:

117558498(egfra)

EMAC:

134865705(egfra) 134884092

ELY:	117264749 117272055(egfra)

EFO:	125882095 125902260(egfra)

PLEP:

121951033(egfra)

SLUC:

116046206(egfra) 116056499

ECRA:

117954310(egfra)

ESP:	116698815(egfr)

PFLV:

114548913 114564973(egfr)

GAT:	120811612 120816150(egfra)

PPUG:

119198448 119204022(egfra)

AFB:	129110777 129111957(egfra)

CLUM:

117746810(egfra) 117749501

PSWI:

130206605

CANA:

137788486 137805300(egfra)

CVE:	137892150 137892156 137892441(egfra)

MSAM:

119901961(egfra) 119913984

SCHU:

122866464 122886268(egfra)

EARM:

139296612(egfra) 139304162

CUD:	121519822(egfra)

SPUL:

138596179 138611091(egfra)

LMIX:

132979283(egfra) 132994563

HTC:	141804103(egfra) 141807370

ALAT:

119008592 119010740(egfra)

ASTR:

137612886(egfra) 137614246

PKLU:

139213746(egfra) 139220929

MZE:	101477281 101483528

ONL:	100695445 100695709(egfr) 100711613 106097625

OAU:	116309666 116316230(egfra) 116331432 120434466

OLA:	101159776(egfr) 101169984

OML:	112147305(egfra) 112151354

CSAI:

133423117 133452222(egfra)

XMA:	102228937 102236062 111606142

XCO:	114136421 114146596(egfr)

XHE:	116712093 116721778(egfr)

PRET:

103456976 103479868(egfr)

PFOR:

103135727(egfr) 103156750

PLAI:

106934486 106948569(egfr)

PMEI:

106903456 106924542(egfr)

GAF:	122824379 122841048(egfra)

PPRL:

129354379 129362259(egfra)

CVG:	107081719(egfr) 107098892

CTUL:

119787990 119794178(egfra)

GMU:	124858134 124869445(egfra)

NFU:	107383161 107383833(egfr)

KMR:	108241698(egfra) 108250946

ALIM:

106531647 106533007(egfr)

NWH:	119415174(egfra)

AOCE:

111573600(egfra) 111586710

EJA:	138203074(egfra) 138215429

BFRE:

138617336(egfra) 138637040

MCEP:

125010468(egfra)

CSEM:

103377298 103396351(egfr)

POV:	109645925 109646379(egfr) 109646791

SSEN:

122769592 122770192(egfra)

SSOE:

131459216(egfra) 131460245

HHIP:

117753648 117777712(egfra)

HSP:	118098524 118117214(egfra)

PPLT:

128425749 128454072(egfra)

SMAU:

118291002 118310623(egfra)

LCF:	108883329(egfra) 108894667

SDU:	111231258(egfr) 111237405

SLAL:

111647380 111652941(egfr)

XGL:	120789875 120798813(egfra)

HCQ:	109521299(egfr) 109530291

SSCV:

125984752(egfra) 125986336

SBIA:

133492507 133510794(egfra)

PEE:	133396747 133411354(egfra)

PTAO:

133470267 133488957(egfra)

BPEC:

110170351(egfr)

ENY:	140356128(egfra) 140364910

MALB:

109953264 109955384

BSPL:

114844700(egfra) 114853312

SJO:	128368535(egfra) 128382094

SSCO:

133990959(egfra)

TTY:	137173427 137194347(egfra)

GMH:	115537086 115548815

SASA:

106569312 106579586 106590362 106600426

STRU:

115150387 115157224 115169555 115195550

OTW:	112226767 112227760 112232691 112260663

OMY:	110489727 110508550 110530977 110535279

OGO:	123991361 124009655 124039606 124041721

ONE:	115102928 115104890 115114592 115130182

OKI:	109871972 109874573 109899305 109909822

OKE:	118361762 118370654 118394834 118401938

OMM:	135512202 135517289 135522879 135558868

OCLA:

139367016 139376202 139386810 139420209

SALP:

111953517 111956947 111972787 111979429

SNH:	120020248 120028154 120051015 120055996

SFON:

129813767 129823074 129824193 129859179

CCLU:

121535557 121549646 121569195 121581068

ELS:	105019998 105027310

OEP:	134035265 134036970(egfra)

SFM:	108937670(egfr)

PKI:	111841598 111845900

AANG:

118225251 118234624(egfra)

AROT:

135252421 135261047(egfra)

CCOG:

133125881 133136252(egfra)

LOC:	102688253(egfr)

PSPA:

121313118 121314598

ARUT:

117400452(egfra)

PSEX:

120529821

CMK:	103181270(egfra)

RTP:	109927384(egfra)

CPLA:

122549920

CPUN:

140480598(egfra)

HOC:	132815743(egfra)

SCAU:

119966315(egfra)

LERI:

129710134(egfra)

HAKA:

140732158(egfra)

BFO:	118405919 118406087

BBEL:

109465242

SPU:

586488

LPIC:

129255739

LVG:	121405695 121429404

AJJ:	139964576 139965011 139965012

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

139143239 139143243 139143274

DME:	Dmel_CG10079(Egfr)

DER:

6548211

DSE:

6615396

DSI:	Dsimw501_GD11601(Dsim_GD11601)

DYA:	Dyak_GE12201

DAN:

DSR:

DPO:

DPE:

DMN:	108159444 117192251

DWI:

6637989

DGR:

6560193

DMO:	Dmoj_GI19081

DAZ:

108615522

DNV:

108653770

DHE:

111592533

DVI:	6627038(Egfr)

CCAT:

101448716

BOD:

106627005

BDR:

105222837

RZE:	108377088 108377827

AOQ:

129243729

ALUD:

128868674

TDA:	119673883 119674679

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135961949(Egfr)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009203

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:	105193398 105207029

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108726392(Egfr)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139110493(Egfr)

TLN:	139809931(Egfr)

TAME:

143895499(Egfr)

HST:

DQU:

CFO:

FEX:

PMEC:

138941458(Egfr)

LHU:	105676042(Egfr)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141536838(Egfr)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124212778(Egfr)

NFB:

NLO:

NVG:

AROA:

TCA:	660037(DER)

TMOL:

138132848(Egfr)

DPA:

109536124

ESIM:

136415702(Egfr)

EFOR:

136344315(Egfr)

SOY:

115880442

RFG:	143198519(Egfr)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206801

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933821(Egfr)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141436872(Egfr)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106685904(Egfr)

NLU:

111048742

LDA:	142329391(Egfr)

HVI:

124361165

MQU:

128993909

PHU:	Phum_PHUM581050

FOC:

113209899

TPAL:

117653548

ZNE:

110832144

PAME:

138704922(Egfr)

SGRE:

126268110

BROR:

134546234

IEL:

124167060

HAMR:

139693716 139697523(Egfr)

FCD:

110842323

DPX:	DAPPUDRAFT_53919

DMK:

116929417

DPZ:	124311792 124352509

AFRA:

136034012

PVM:	113823280 113828952(Egfr)

PJA:	122249052 122264942

PCHN:

125039282 125046409

PMOO:

119586189 119591303

HAME:

121865936

PCLA:

123756738(Egfr)

CQD:	128691614(Egfr)

PTRU:

123509689

ESN:

127007678

MNZ:

135207253

MRJ:	136850583(Egfr)

PORN:

139745971(Egfr)

HAZT:

108676933

OOT:	143039778(Egfr)

EAF:

111709702

LSM:	121115122(Egfr)

TCF:

PPOI:

ISC:

DSV:

DALB:

135909641(Egfr)

RSAN:

RMP:

OTI:

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129224607 129229927

SDM:	118188541 118193031

LPOL:

106459039 106459299 106469174 106469386 106474302

PMEO:

129588700

CEL:	CELE_ZK1067.1(let-23)

CBR:	CBG_00911(Cbr-let-23)

CRQ:	GCK72_003626

NAI:	NECAME_12048

BMY:	BM_BM7615(Bma-let-23)

LOA:	LOAG_06524

HRO:	HELRODRAFT_119222

LGI:	LOTGIDRAFT_139618

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:	105330118(Egfr)

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MMER:

123537817 123538470 123539108 123557773

RPHI:

132741093

DPOL:

127843704

MAEA:

128240810

OBI:	106867517 106869050 106882365

OSN:	115215570 115215587

LJP:

135464437

LAK:

106153603

SMM:	Smp_093930.1 Smp_152680 Smp_165470

SHX:	MS3_00003326(ERBB2_1) MS3_00003585(ERBB2_2)

OVI:	T265_04554 T265_07922 T265_12870 T265_13536

EGL:	EGR_03329 EGR_05468 EGR_07164

LLON:

135499658

AQU:

100637905

MBR:	MONBRDRAFT_27552 MONBRDRAFT_39306

SRE:	PTSG_04246 PTSG_04263

» show all

Reference

PMID:12873986

Authors

Shao H, Cheng HY, Cook RG, Tweardy DJ

Title

Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.

Journal

Cancer Res 63:3923-30 (2003)

Sequence

[hsa:1956]

Reference

PMID:11116146

Authors

Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T

Title

The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.

Journal

J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200

Sequence

[hsa:1956]

Reference

PMID:6328312

Authors

Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.

Title

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.

Journal

Nature 309:418-25 (1984)
DOI:10.1038/309418a0

Sequence

[hsa:1956]

LinkDB

ORTHOLOGY: K04362

Entry

K04362                      KO

Symbol

FGFR1, CD331

Name

fibroblast growth factor receptor 1 [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04517

IgSF CAM signaling

map04520

Adherens junction

map04550

Signaling pathways regulating pluripotency of stem cells

map04714

Thermogenesis

map04810

Regulation of actin cytoskeleton

map04928

Parathyroid hormone synthesis, secretion and action

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05215

Prostate cancer

map05218

Melanoma

map05224

Breast cancer

map05230

Central carbon metabolism in cancer

Disease

H00031

Breast cancer

H00255

Hypogonadotropic hypogonadism

H00443

Osteoglophonic dysplasia

H00458

Syndromic craniosynostoses

H01207

Trigonocephaly

H01756

Pfeiffer syndrome

H01850

Hartsfield syndrome

H01988

Jackson-Weiss syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04014 Ras signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04015 Rap1 signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04020 Calcium signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04151 PI3K-Akt signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05205 Proteoglycans in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05230 Central carbon metabolism in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09162 Cancer: specific types
   05218 Melanoma
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05215 Prostate cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05224 Breast cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   00536 Glycosaminoglycan binding proteins
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
CD molecules [BR:ko04090]
Proteins
  K04362  CD331, FGFR1; fibroblast growth factor receptor 1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1

Other DBs

GO:

0005007

Genes

HSA:	2260(FGFR1)

PTR:	464122(FGFR1)

PPS:	100988115(FGFR1)

GGO:	101152179(FGFR1)

PON:	100174545(FGFR1)

PPYG:

129042504(FGFR1)

NLE:	100602423(FGFR1)

HMH:	116462129(FGFR1)

SSYN:

129491526(FGFR1)

MCC:	700126(FGFR1)

MCF:	102144714(FGFR1)

MTHB:

126961189

MNI:	105476567(FGFR1)

CSAB:

103215648(FGFR1)

CATY:

105590801(FGFR1)

PANU:

101002603(FGFR1)

TGE:	112629744(FGFR1)

MLEU:

105548990

RRO:	104679640(FGFR1)

RBB:	108512401(FGFR1)

TFN:	117094867(FGFR1)

PTEH:

111544121(FGFR1)

CANG:

105525157(FGFR1)

CJC:	100390192(FGFR1)

SBQ:	101033213(FGFR1)

CIMI:

108309970(FGFR1)

ANAN:

105733510(FGFR1)

CSYR:

103274944(FGFR1)

MMUR:

105870403(FGFR1)

LCAT:

123626670(FGFR1)

ERUF:

138393644(FGFR1)

PCOQ:

105815854(FGFR1)

OGA:	100960708(FGFR1)

MMU:	14182(Fgfr1)

MCAL:

110299550(Fgfr1)

MPAH:

110336809(Fgfr1)

RNO:	79114(Fgfr1)

MCOC:

116069056(Fgfr1)

ANU:	117722071(Fgfr1)

ASYL:

127668903(Fgfr1)

MUN:	110563307(Fgfr1)

CGE:	100773586(Fgfr1)

MAUA:

101842486(Fgfr1)

PROB:

127220342(Fgfr1)

PLEU:

114681341(Fgfr1)

PMAV:

102925907(Fgfr1)

MORG:

121462200(Fgfr1)

MFOT:

126504434

AAMP:

119811944(Fgfr1)

CNL:	130862598(Fgfr1)

NGI:	103745770(Fgfr1)

HGL:	101700324(Fgfr1)

CPOC:

100731156(Fgfr1)

CCAN:

109688936(Fgfr1)

DORD:

105992799(Fgfr1)

DSP:	122107616(Fgfr1)

DMER:

138823161(Fgfr1)

PLOP:

125339698(Fgfr1)

NCAR:

124983698

MMMA:

107155394(Fgfr1)

ITI:	101977965(Fgfr1)

OCU:

100351861

OPI:	101534918(FGFR1)

OCZ:	121149974(FGFR1)

TUP:	102484087(FGFR1)

GVR:	103598755(FGFR1)

CFA:	100856477(FGFR1)

CLUD:

112649669(FGFR1)

VVP:	112916136(FGFR1)

VLG:	121489119(FGFR1)

NPO:	129515655(FGFR1)

AML:	100472630(FGFR1)

UMR:	103659146(FGFR1)

UAH:	113262086(FGFR1)

UAR:	123780346(FGFR1)

ELK:

111144420

LLV:

125092758

MPUF:

101691149(FGFR1)

MNP:	132006317(FGFR1)

MLK:	131820646(FGFR1)

NVS:	122889876(FGFR1)

ORO:	101364849(FGFR1)

EJU:	114224838(FGFR1)

ZCA:	113924319(FGFR1)

MLX:	118009956(FGFR1)

NSU:	110573154(FGFR1)

LWW:	102734086(FGFR1)

FCA:	101086055(FGFR1)

PYU:	121017369(FGFR1)

PCOO:

112858029(FGFR1)

PBG:	122473425(FGFR1)

PVIV:

125163506(FGFR1)

LRUF:

124520453

LGF:	123588895(FGFR1)

AJU:

106978376

PTG:	102972346(FGFR1)

PPAD:

109262303(FGFR1)

PUC:

125923281

PLEZ:

122217613(FGFR1)

HHV:	120238662(FGFR1)

BTA:	281768(FGFR1)

BOM:	102267776(FGFR1)

BIU:	109553304(FGFR1)

BBUB:

102407288(FGFR1)

BKE:	129643001(FGFR1)

BBIS:

104987781(FGFR1)

CHX:	102180282(FGFR1)

OAS:	780507(FGFR1)

BTAX:

128068375(FGFR1)

CSUM:

138079229(FGFR1)

ODA:	120865665(FGFR1)

CCAD:

122432228(FGFR1)

MREE:

136176884(FGFR1)

OVR:	110126587(FGFR1)

MBEZ:

129549407(FGFR1)

SSC:	100153248(FGFR1)

CFR:	102515264(FGFR1)

CBAI:

105071441(FGFR1)

CDK:	105105270(FGFR1)

VPC:	102531272(FGFR1)

BACU:

103017733(FGFR1)

BMUS:

118887767(FGFR1)

LVE:	103069902(FGFR1)

OOR:	101279623(FGFR1)

LALB:

132512743(FGFR1)

GMF:	115840502(FGFR1)

DDP:	132417589(FGFR1)

DLE:	111173523(FGFR1)

PCAD:

102989551(FGFR1)

PSIU:

116746732(FGFR1)

PPHC:

136141836(FGFR1)

NASI:

112413123(FGFR1)

ECB:	100057614(FGFR1)

EPZ:	103560266(FGFR1)

EAI:	106824659(FGFR1)

MYB:	102253832(FGFR1)

MYD:	102759202(FGFR1)

MMYO:

118649562(FGFR1)

MLF:	102423450(FGFR1)

MDT:	132228629(FGFR1)

MYUM:

139006002(FGFR1)

PKL:	118728579(FGFR1)

EFUS:

103290249(FGFR1)

MNA:	107535065(FGFR1)

DRO:	112306733(FGFR1)

SHON:

118993177(FGFR1)

AJM:	119065040(FGFR1)

PDIC:

114508370(FGFR1)

PHAS:

123807471(FGFR1)

MMF:	118622697(FGFR1)

PPAM:

129064807(FGFR1)

HAI:	109373149(FGFR1)

RFQ:	117021283(FGFR1)

PALE:

102898943(FGFR1)

PGIG:

120595650(FGFR1)

PVP:	105300315(FGFR1)

RAY:	107515961(FGFR1)

MJV:	108403050(FGFR1)

TOD:	119257820(FGFR1)

SARA:

101544250(FGFR1)

SFUM:

130026085(FGFR1)

SETR:

126006406(FGFR1)

LAV:	100662289(FGFR1)

TMU:

101342270

ETF:	101650479(FGFR1)

DNM:	101427669(FGFR1)

MDO:	100029852(FGFR1)

GAS:	123236988(FGFR1)

SHR:	100914347(FGFR1)

AFZ:

127548241

PCW:	110207578(FGFR1)

TVP:	118842877(FGFR1)

PBRV:

138152113(FGFR1)

MLAO:

141503825(FGFR1)

OAA:	100074240(FGFR1)

TACU:

119928140(FGFR1)

GGA:	396516(FGFR1)

PCOC:

116234528(FGFR1)

MGP:	100547498(FGFR1)

CJO:	107323773(FGFR1)

TPAI:

128089959(FGFR1)

LMUT:

125685203(FGFR1)

NMEL:

110387131(FGFR1)

APLA:

119713481(FGFR1)

AACU:

137845221(FGFR1)

ACYG:

106044374(FGFR1)

CATA:

118256011(FGFR1)

AFUL:

116499369(FGFR1)

TGU:	100221243(FGFR1)

LSR:	110473397(FGFR1)

SCAN:

103822693(FGFR1)

PMOA:

120505592(FGFR1)

OTC:	121346743(FGFR1)

PRUF:

121359634(FGFR1)

ATRC:

139603848(FGFR1)

GFR:	102033908(FGFR1)

FAB:	101822220(FGFR1)

OMA:	130262007(FGFR1) 130266558

PHI:	102103637(FGFR1)

PMAJ:

107213845(FGFR1)

CCAE:

111938850(FGFR1)

CCW:	104694904(FGFR1)

CBRC:

103614656(FGFR1)

ACOE:

138121591(FGFR1)

ETL:	114066493(FGFR1)

ZLE:	135456901(FGFR1)

ACHL:

103797002

SVG:	106862051(FGFR1)

HRT:	120764055(FGFR1)

SATI:

136372585(FGFR1)

CFAI:

136302859(FGFR1)

CCIC:

134054801(FGFR1)

FPG:	101914093(FGFR1)

FCH:	102055369(FGFR1)

CCRI:

104160033

SHAB:

115618404(FGFR1)

SURA:

141935646(FGFR1)

TALA:

116962981(FGFR1)

ACHC:

115350076(FGFR1)

HLE:	104828804(FGFR1)

AGEN:

126051549

HHAR:

128150091(FGFR1)

BBUT:

142038225(FGFR1)

GCL:

127025218

DPUB:

104301278(FGFR1)

PPUS:

135192481(FGFR1)

EGZ:	104135322(FGFR1)

NNI:	104016019(FGFR1)

PADL:

103912362(FGFR1)

AFOR:

103897295(FGFR1)

CBOR:

142093611(FGFR1)

CBOY:

140643782(FGFR1)

MAME:

142420204(FGFR1)

CLV:	102085235(FGFR1)

CNIC:

135998389(FGFR1)

EHS:

104513763

CUCA:

104068578(FGFR1)

GAME:

129196709(FGFR1)

CPEA:

104384843(FGFR1)

CVF:

104283349

RTD:	128900067(FGFR1)

CRID:

134526559(FGFR1)

LMIC:

141733493(FGFR1)

NARQ:

141475690(FGFR1)

AAM:	106492992(FGFR1)

AROW:

112965467(FGFR1)

NPD:	112952906(FGFR1)

TGT:	104576676(FGFR1)

DNE:	112991606(FGFR1)

SCAM:

104148747(FGFR1)

ASN:	102386174(FGFR1)

AMJ:	102574117(FGFR1)

CPOO:

109317416(FGFR1)

GGN:	109295541(FGFR1)

PSS:	102461506(FGFR1)

CIZ:	142004204(FGFR1)

CMY:	102942878(FGFR1)

CCAY:

125626448(FGFR1)

LKP:	140903655(FGFR1)

NDS:	141978229(FGFR1)

DCC:	119848596(FGFR1)

CPIC:

101941076(FGFR1)

TST:	117873025(FGFR1)

CABI:

116821412(FGFR1)

MRV:	120397459(FGFR1)

ACS:	100559018(fgfr1)

ASAO:

132782814(FGFR1)

PVT:	110072166(FGFR1)

SUND:

121935105(FGFR1)

PBI:	103066603(FGFR1)

PMUR:

107289991(FGFR1)

CTIG:

120312914(FGFR1)

TSR:	106545617(FGFR1)

PGUT:

117674750(FGFR1)

PCAE:

139323161(FGFR1)

APRI:

131203823(FGFR1)

PTEX:

113445594 113445646

NSS:	113420990(FGFR1)

VKO:	123026996(FGFR1)

PMUA:

114585343(FGFR1)

PRAF:

128403030(FGFR1)

ZVI:	118097182(FGFR1)

HCG:	128333755(FGFR1)

GJA:	107113006(FGFR1)

STOW:

125441423(FGFR1)

EMC:	129342594(FGFR1)

XLA:	397782(xfgfra2) 399444(fgfr1.L)

XTR:	548648(fgfr1)

NPR:	108791453(FGFR1)

RTEM:

120933172(FGFR1)

ACAT:

141133155(FGFR1)

PADS:

140323052(FGFR1) 140332382

BBUF:

120986282(FGFR1)

BGAR:

122927312(FGFR1)

DTC:	141100386(FGFR1)

PWL:	138265881(FGFR1)

MUO:	115469362(FGFR1)

GSH:	117362782(FGFR1)

DRE:	30705(fgfr1a) 567905(fgfr1b) 569566(fgfr1bl)

SRX:	107710851 107718699 107721100 107758647

SANH:

107658606 107678426 107678428 107689322 107698118

SGH:	107553171 107559452 107559453 107588986 107602069

CCAR:

109055353(fgfr1b) 109060897 109097286 109108459

CAUA:

113039674 113043354 113054578 113107281 113110238

CGIB:

127963643 127966872 128018226 128020722

PTET:

122350549(fgfr1a) 122353144(fgfr1b)

LROH:

127169481(fgfr1a) 127172252(fgfr1b)

GRF:	141287025(fgfr1a) 141299876(fgfr1b)

OMC:	131545319(fgfr1a) 131548345(fgfr1b)

PPRM:

120481189 120482211

RKG:	130077891(fgfr1b) 130082101(fgfr1a)

MAMB:

125262353(fgfr1b) 125280415

CIDE:

127516937 127521512

CERY:

137027346 137028576(fgfr1b)

MASI:

127415449 127423957 127432858 127433807

TROS:

130546070(fgfr1b) 130567765(fgfr1a)

TDW:	130411550(fgfr1b) 130439863(fgfr1a)

MANU:

129413739(fgfr1a) 129446557

PDAB:

135729799(fgfr1a) 135744046(fgfr1b)

IPU:

108265400

IFU:	128607454 128607532

PHYP:

113533113 113533198

SMEO:

124399782(fgfr1a)

TFD:	113656143(fgfr1a)

TVC:	132853271(fgfr1a)

CGAR:

128529916(fgfr1a)

NGRA:

132892871(fgfr1a)

TRN:	134318405(fgfr1a)

AMEX:

103022888 103036914(fgfr1a)

CMAO:

118813294(fgfr1a)

EEE:

113588173

CHAR:

105902754(fgfr1a) 105912648(fgfr1b)

SPIL:

134088551(fgfr1a) 134100610(fgfr1b)

ASAD:

121679958(fgfr1b) 121715218

TRU:	101073964 101078564(fgfr1)

TFS:	130517404 130525797(fgfr1a)

TNG:	GSTEN00025402G001 GSTEN00034863G001

LCO:	104930673 104936599(fgfr1) 104938329

NCC:	104959008 104963581

TBEN:

117472589(fgfr1a) 117482623(fgfr1b)

CGOB:

115013012

PGEO:

117442227(fgfr1b) 117442377 117442378

GACU:

117533212 117543910(fgfr1a)

EMAC:

134868641(fgfr1b) 134873511(fgfr1a)

ELY:	117252130(fgfr1a) 117269626

EFO:	125889847(fgfr1a) 125906055

PLEP:

121944930(fgfr1a) 121960119

SLUC:

116041780 116050569(fgfr1a) 116050702

ECRA:

117944490(fgfr1a)

ESP:	116687052 116690381

PFLV:

114555046(fgfr1) 114571184

GAT:	120830735(fgfr1a) 120831703(fgfr1b)

PPUG:

119225164(fgfr1a) 119226955(fgfr1b)

AFB:	129101786(fgfr1a) 129102869(fgfr1b)

CLUM:

117740043(fgfr1b)

PSWI:

130196352(fgfr1a) 130205528(fgfr1b)

CANA:

137783538(fgfr1b) 137804960(fgfr1a)

CVE:	137867618(fgfr1a) 137869134

MSAM:

119891967(fgfr1a) 119914512

SCHU:

122865728(fgfr1b) 122876285(fgfr1a)

EARM:

139284345(fgfr1a) 139300994(fgfr1b)

CUD:	121509445(fgfr1a) 121524792

SPUL:

138601753(fgfr1b) 138610862(fgfr1a)

LMIX:

132968614 132973930(fgfr1a)

HTC:	141789973(fgfr1a) 141805194

ALAT:

119019249(fgfr1a) 119030510(fgfr1b)

ASTR:

137592726 137608011(fgfr1b)

PKLU:

139204038(fgfr1a) 139218453(fgfr1b)

MZE:	101469987 101470033 101480030

ONL:	100698136(fgfr1a) 100707841 100708380 102078731

OAU:	116313544(fgfr1a) 116321739 116321763

OLA:	100125448(fgfr1) 101155126

OML:	112148278(fgfr1a) 112162937

CSAI:

133451402(fgfr1a) 133455174(fgfr1b)

XMA:	102225656 102231629 111611934

XCO:	114149547 114154182(fgfr1)

XHE:	116724736 116729276(fgfr1)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122819204(fgfr1b) 122828077(fgfr1a)

PPRL:

129373089(fgfr1a) 129379807(fgfr1b)

CVG:

107081801

CTUL:

119790883(fgfr1a)

GMU:	124877368(fgfr1a)

NFU:	107393607 107394749

KMR:	108231094(fgfr1b) 108239355(si:ch211-167j9.5) 108247308(fgfr1a)

ALIM:

106524404 106529794 106530655

NWH:	119414055(fgfr1a) 119424280

AOCE:

111571065(fgfr1a) 111586930(fgfr1b)

EJA:	138208771(fgfr1b) 138215726(fgfr1a)

BFRE:

138622301(fgfr1b) 138625645(fgfr1a)

MCEP:

124996417 125011982(fgfr1a)

CSEM:

103389364 103398805

POV:	109642369 109647136

SSEN:

122764198 122770547(fgfr1a)

SSOE:

131446349(fgfr1b) 131463504(fgfr1a)

HHIP:

117767647(fgfr1a) 117771314(fgfr1b)

HSP:	118114999(fgfr1a) 118126069(fgfr1b)

PPLT:

128424600(fgfr1b) 128438326(fgfr1a)

SMAU:

118285274(fgfr1b) 118313772(fgfr1a)

LCF:	108878351(fgfr1a) 108895850

SDU:	111224260 111226155 111226297

SLAL:

111644951 111664470 111665471

XGL:	120805029(fgfr1a) 120806286(fgfr1b)

HCQ:	109511602 109519580

SSCV:

125993601(fgfr1a)

SBIA:

133490507 133499138(fgfr1a)

PEE:	133400419(fgfr1a) 133413432

PTAO:

133474608(fgfr1a) 133489921

BPEC:

110161621 110163358

ENY:	140346429(fgfr1a) 140367632(fgfr1b)

MALB:

109954836

BSPL:

114861756(fgfr1a) 114866928(fgfr1b)

SJO:	128364763(fgfr1a) 128380116

SSCO:

133978710(fgfr1a) 133995525

TTY:	137170484(fgfr1b) 137193156(fgfr1a)

GMH:	115542562 115545455

SASA:

106563063 106567959 106579865 106585563

STRU:

115159756 115164552 115200093 115203912

OTW:	112220247 112230834(fgfr1b) 112248453 112262942(fgfr1a)

OMY:	110509647(fgfr1b) 110523426 110525633 110533886 110535999(fgfr1a) 110537233

OGO:	124007249(fgfr1b) 124034343 124036276(fgfr1a) 124049109

ONE:	115101025 115111572 115120928 115140013

OKI:	109868541 109874208 109879266 109895868

OKE:	118358309(fgfr1a) 118374923 118385446(fgfr1b) 118393173

OMM:	135514133(fgfr1a) 135518115 135541255 135544613(fgfr1b)

OCLA:

139388034 139390248 139408519 139410885

SALP:

111957683 111961779 111963890 111974100

SNH:	120021867(fgfr1b) 120025797 120063215(fgfr1a) 120066669

SFON:

129818225 129826276(fgfr1a) 129853534 129863785(fgfr1b)

CCLU:

121530868 121541540 121582664 121584814

ELS:	105014025 105015194

OEP:	134012113(fgfr1a) 134038598(fgfr1b)

SFM:	108923597 108929518

PKI:	111843816 111857512

AANG:

118206299(fgfr1a) 118212554(fgfr1b)

AROT:

135239583(fgfr1b) 135261262(fgfr1a)

CCOG:

133141346(fgfr1a)

LOC:	102691524(fgfr1)

PSPA:

121302321 121303070

ARUT:

117397731 117962604

PSEX:

120538938(fgfr1a)

LCM:	102361014(FGFR1)

CMK:

RTP:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

LRJ:	133361933 133362317 133362733

BFO:	118403013 118403014 118403147 118404297 118404304 118408196 118408526 118409814 118414472 118420064 118422029 118425789 118427934 118431379 118431526 118432209 118432315

BBEL:

109464065 109470729 109471329 109471744 109478415 109478559 109478611 109480472 109480616 109481311 109485722 109485995

CIN:	101242971 445706(fgfr)

SCLV:

120339737 120339945 120341741 120343076 120345170

CLEP:

143444167 143461286 143461626

SPU:	373310(FGFR)

LVG:	121419550 121419651 121419810 121419959 121420007 121420312 121420360 121420820 121420822 121430953

AJJ:	139961525 139977428 139977468 139977569 139978910

APLC:

110973888 110988178 110988925 110988938

ARUN:

117290835 117294893 117301368 117301480 117301536 117301646 117301660 117304945 117305077 117305108 117305207 117305343 117305799 117305801 117305802 117306638

AAMU:

139941110 139947791 139947807 139951564 139951568 139951569 139951570 139951572 139951577 139951580 139951639 139951641 139951827 139953958 139953984 139953994 139953995 139954039

AFIL:

140141660 140143820 140144028 140144220 140144228 140154842 140163040 140163141 140165273 140167048 140169383 140169425 140169600 140169623 140170016 140170017 140170023 140170385 140170457

SKO:	100306925(fgfrb) 100373313 100376937 102804031

DME:	Dmel_CG10244(Cad96Ca)

DER:

6555476

DSE:

6619674

DSI:	Dsimw501_GD18227(Dsim_GD18227)

DYA:	Dyak_GE10728

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23865

DAZ:

108621257

DNV:

108650218

DHE:

111601307

DVI:	6629492(Cad96Ca)

CCAT:

101456091

BOD:

106624537

BDR:

105234087

RZE:	108358626 108373614

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135963234(Cad96Ca)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:	117603088 117610181

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108722548(Cad96Ca)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:	105557000 105568403

COBS:

139108421(Cad96ca)

TLN:	139810696(Cad96ca)

TAME:

143904212(Cad96ca)

HST:	105183302 105191559

DQU:

106748875

CFO:

105254933

FEX:

115233632

PMEC:

138933068(Cad96ca)

LHU:	105675703(Cad96Ca)

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100114847 100122026

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141537736(Cad96ca)

FAS:	105272314 105273651

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124213892(Cad96Ca)

NFB:

NLO:

NVG:

AROA:

TCA:	659961(Cad96Ca)

TMOL:

138135206(Cad96Ca)

DPA:

109536590

ESIM:

136413703(Cad96Ca)

EFOR:

136339675(Cad96Ca)

SOY:

RFG:

AGRG:

ATD:

CSET:

HAXR:

AGB:	108905147 108908858 108912100

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209816

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137931555(Cad96Ca)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141427592(Cad96Ca)

CFEL:

113389731 113389732 113389735

CCRN:

123305807

API:	100160364 100164198

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106687640(Cad96Ca) 106689173

NLU:

111046370

LDA:	142322141(Cad96Ca)

HVI:	124359358 124371349

MQU:	128990070 128997572

PHU:	Phum_PHUM596340

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138709091(Cad96Ca)

SGRE:

126278525

BROR:

134533468

IEL:

124161013

HAMR:

139687126(Cad96Ca)

FCD:	110843069 110857842

DPX:	DAPPUDRAFT_110251 DAPPUDRAFT_302458 DAPPUDRAFT_60789

DMK:	116923958 116932530

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128690245(Cad96Ca) 128693385

PTRU:

123507697

MNZ:

135226143

MRJ:

136839551

PORN:

139749225(Cad96Ca)

HAZT:

108671962

EAF:	111712748 111714420

LSM:	121118123 121119878 121127299 121129259

TCF:	131884365 131891921

PPOI:

119099240 119112430

ISC:

120836739

DSV:	119436233 119436586

DALB:

135917605(Cad96Ca) 139048123

RSAN:

119399215 119399839 119403696

RMP:	119161507 119187706

OTI:

135368831

VDE:

111255383

VJA:

111261194

GOE:	100897699 114828397

TUT:

107365937

DPTE:

113790798

DFR:	124496652 124497306 124497308 124498557

CSCU:

111627893 111629419

CVS:	136970181(Cad96Ca) 136971369 136973005

PTEP:

107441235

ABRU:

129963280 129963892 129977520

UDV:	129216949 129234182

SDM:	118181410 118181411 118182383 118186648

LPOL:

106459239

PMEO:

129593865 129600151

TSP:

Tsp_00617

HRO:	HELRODRAFT_175642

PVUL:

126815164

PCAN:

112568152 112570062 112570875

LSAX:

138974230

BARL:

143291544

BGT:	106050562 106059224

GAE:	121385852 121386032 121386653 121386776 121390303

HRF:	124112116 124113551 124113552 124115437 124148006

HRJ:	124254081 124254092 124256796 124259770 124286101

HASI:

137260937 137265580

HCRA:

139453368 139460752 139466831 139472856

CRG:	105321229 105336611 105347497

CVN:	111100896 111111978

OED:

125659022

MYI:

110459294

PMAX:

117340339 117340856 117343882

AIRR:

YBA:

MMER:

MAEA:

OSN:

LJP:	135466884 135482293

LAK:	106157808 106157883 106159857 106166647

OVI:	T265_09735

EGL:

EGR_04208

NVE:	5509675 5511426 5512388 5515109 5521177 5521369

EPA:	110232833 110233109 110233280 110234660 110235402 110238206 110251279 110251328

ATEN:

116286573 116287613 116287775 116300656 116300659 116300991 116302239 116304555

ADF:	107331817 107337812 107340997 107341311 107351445 107352141 107354939 107355168

AMIL:

114948548 114949249 114962172 114963002 114963003 114963397 114968101 114969232 114969992 114977686 122948798

PDAM:

113666316 113666620 113681199 113685543 113685932

SPIS:

111322705 111323588 111328130 111332237 111332637 111332638 111334138 111334648 111339275 111340803

DGT:	114526319 114526924 114529830 114535618

XEN:	124441598 124441614 124441627 124444411 124444525 124445587 124445861 124446172 124446461 124447192 124447353

HMG:

100199016

HSY:

130644897

RES:	135682428 135686188 135687034 135688754 135696213

TAD:	TRIADDRAFT_25090

AQU:

100632318

MBR:	MONBRDRAFT_29090

» show all

Reference

PMID:1697263

Authors

Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J

Title

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

Journal

EMBO J 9:2685-92 (1990)
DOI:10.1002/j.1460-2075.1990.tb07454.x

Sequence

[hsa:2260]

LinkDB

ORTHOLOGY: K04363

Entry

K04363                      KO

Symbol

PDGFRA, CD140A

Name

platelet-derived growth factor receptor alpha [EC:2.7.10.1]

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04072

Phospholipase D signaling pathway

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map05163

Human cytomegalovirus infection

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05230

Central carbon metabolism in cancer

map05231

Choline metabolism in cancer

Disease

H00042

Glioma

H01590

Chronic eosinophilic leukemia

H01591

Gastrotintestinal stromal tumor

H01599

Hypereosinophilic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 JAK-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09162 Cancer: specific types
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide

Other DBs

GO:

0005018

Genes

HSA:	5156(PDGFRA)

PTR:	461318(PDGFRA)

PPS:	100982337(PDGFRA)

GGO:	101124928(PDGFRA)

PON:	100431735(PDGFRA)

PPYG:

129035620(PDGFRA)

NLE:	100603207(PDGFRA)

HMH:	116467343(PDGFRA)

SSYN:

129491018(PDGFRA)

MCC:	697002(PDGFRA)

MCF:	102138392(PDGFRA)

MTHB:

126954734

MNI:	105463522(PDGFRA)

CSAB:

103235675(PDGFRA)

CATY:

105592013(PDGFRA)

PANU:

101022081(PDGFRA)

TGE:	112625154(PDGFRA)

MLEU:

105529382(PDGFRA)

RRO:	104658857(PDGFRA)

RBB:	108533750(PDGFRA)

TFN:	117085606(PDGFRA)

PTEH:

111520430(PDGFRA)

CANG:

105523780(PDGFRA)

CJC:	100412331(PDGFRA)

SBQ:	101040156(PDGFRA)

CIMI:

108312367(PDGFRA)

ANAN:

105709286(PDGFRA)

CSYR:

103249185(PDGFRA)

MMUR:

105867837(PDGFRA)

LCAT:

123624835(PDGFRA)

ERUF:

138375048(PDGFRA)

PCOQ:

105807665(PDGFRA)

OGA:	100961338(PDGFRA)

MMU:	18595(Pdgfra)

MCAL:

110295292(Pdgfra)

MPAH:

110331028(Pdgfra)

RNO:	25267(Pdgfra)

MCOC:

116071260(Pdgfra)

ANU:	117712829(Pdgfra)

ASYL:

127696005(Pdgfra)

MUN:	110558105(Pdgfra)

CGE:	100760258(Pdgfra)

MAUA:

101822506(Pdgfra)

PROB:

127232306(Pdgfra)

PLEU:

114683759(Pdgfra)

PMAV:

102927320(Pdgfra)

MORG:

121460639(Pdgfra)

MFOT:

126506425

AAMP:

119807129(Pdgfra)

CNL:	130876292(Pdgfra)

NGI:	103734393(Pdgfra)

HGL:	101697360(Pdgfra)

CPOC:

100726209(Pdgfra)

CCAN:

109685094(Pdgfra) 109702274

DORD:

105980318(Pdgfra)

DSP:	122106871(Pdgfra)

DMER:

138820902(Pdgfra)

PLOP:

125364960(Pdgfra)

NCAR:

124995024

MMMA:

107139238(Pdgfra)

ITI:	101956917(Pdgfra)

OCU:

100343006

OPI:	101516125(PDGFRA)

OCZ:	121147270(PDGFRA)

TUP:	102488187(PDGFRA)

GVR:	103589787(PDGFRA)

CFA:	442860(PDGFRA)

CLUD:

112652233(PDGFRA)

VVP:	112933353(PDGFRA)

VLG:	121472891(PDGFRA)

NPO:	129520020(PDGFRA)

AML:	100464991(PDGFRA)

UMR:	103672737(PDGFRA)

UAH:	113262493(PDGFRA)

UAR:	123804080(PDGFRA)

ELK:

111148924

LLV:

125093724

MPUF:

101684479(PDGFRA)

MNP:	132006175(PDGFRA)

MLK:	131824031(PDGFRA)

NVS:	122919222(PDGFRA)

ORO:	101372359(PDGFRA)

EJU:	114206758(PDGFRA)

ZCA:	113925340(PDGFRA)

MLX:	118010522(PDGFRA)

NSU:	110590873(PDGFRA)

LWW:	102746830(PDGFRA)

FCA:	101090765(PDGFRA)

PYU:	121035565(PDGFRA)

PCOO:

112858116(PDGFRA)

PBG:	122478872(PDGFRA)

PVIV:

125163328(PDGFRA)

LRUF:

124520247

LGF:	123595979(PDGFRA)

AJU:

106983998

PTG:	102955481(PDGFRA)

PPAD:

109278988(PDGFRA)

PUC:

125923629

PLEZ:

122218228(PDGFRA)

HHV:	120222584(PDGFRA)

BTA:	282301(PDGFRA)

BOM:	102282598(PDGFRA)

BIU:	109560475(PDGFRA)

BBUB:

102409620(PDGFRA)

BKE:	129657862(PDGFRA)

BBIS:

105002851(PDGFRA)

CHX:	102174007(PDGFRA)

OAS:	101106012(PDGFRA)

BTAX:

128049579(PDGFRA)

CSUM:

138082240(PDGFRA)

ODA:	120862113(PDGFRA)

CCAD:

122427991(PDGFRA)

MREE:

136152653(PDGFRA)

OVR:	110149007(PDGFRA)

MBEZ:

129562088(PDGFRA)

SSC:	100627123(PDGFRA)

CFR:	102512589(PDGFRA)

CBAI:

105077672(PDGFRA)

CDK:	105103397(PDGFRA)

VPC:	102528303(PDGFRA)

BACU:

102998016(PDGFRA)

BMUS:

118895166(PDGFRA)

LVE:	103071473(PDGFRA)

OOR:	101269459(PDGFRA)

LALB:

132519840(PDGFRA)

GMF:	115865632(PDGFRA)

DDP:	132425971(PDGFRA)

DLE:	111169692(PDGFRA)

PCAD:

102994349(PDGFRA)

PSIU:

116754045(PDGFRA)

PPHC:

136123568(PDGFRA)

NASI:

112400744(PDGFRA)

ECB:	100059815(PDGFRA)

EPZ:	103552305(PDGFRA)

EAI:	106839051(PDGFRA)

MYB:	102255326(PDGFRA)

MYD:	102761943(PDGFRA)

MMYO:

118668634(PDGFRA)

MLF:	102417415(PDGFRA)

MDT:	132219042(PDGFRA)

MYUM:

138995823(PDGFRA)

PKL:	118706667(PDGFRA)

EFUS:

103284970(PDGFRA)

MNA:	107532710(PDGFRA)

DRO:	112316918(PDGFRA)

SHON:

118978642(PDGFRA)

AJM:	119054288(PDGFRA)

PDIC:

114493180(PDGFRA)

PHAS:

123815579(PDGFRA)

MMF:	118624129(PDGFRA)

PPAM:

129077631(PDGFRA)

HAI:	109381815(PDGFRA)

RFQ:	117022011(PDGFRA)

PALE:

102895362(PDGFRA)

PGIG:

120588066(PDGFRA)

PVP:	105293808(PDGFRA)

RAY:	107499793(PDGFRA)

MJV:	108385741(PDGFRA)

TOD:	119261223(PDGFRA)

SARA:

101539850(PDGFRA)

SFUM:

130020701(PDGFRA)

SETR:

126032431(PDGFRA)

LAV:	100670735(PDGFRA)

TMU:

101348884

ETF:	101663213(PDGFRA)

DNM:	101428297(PDGFRA)

MDO:	100013088(PDGFRA)

GAS:	123252399(PDGFRA)

SHR:	100925116(PDGFRA)

AFZ:

127539873

PCW:	110200158(PDGFRA)

TVP:	118852904(PDGFRA)

PBRV:

138175015(PDGFRA)

MLAO:

141517927(PDGFRA)

OAA:	100084432(PDGFRA)

TACU:

119921351 119921585 119921660 119921810 119922718 119923131 119943426 119947722(PDGFRA)

GGA:	395509(PDGFRA)

PCOC:

116225916(PDGFRA)

MGP:	100542010(PDGFRA)

CJO:	107313741(PDGFRA)

TPAI:

128080542(PDGFRA)

LMUT:

125692539(PDGFRA)

NMEL:

110397725(PDGFRA)

APLA:

101797285(PDGFRA)

AACU:

137855794(PDGFRA)

ACYG:

106030788(PDGFRA)

CATA:

118248600(PDGFRA)

AFUL:

116488453(PDGFRA)

TGU:	100218386(PDGFRA)

LSR:	110469831(PDGFRA)

SCAN:

103825217(PDGFRA)

PMOA:

120497403(PDGFRA)

OTC:	121334956(PDGFRA)

PRUF:

121349389(PDGFRA)

ATRC:

139592450(PDGFRA)

GFR:	102044274(PDGFRA)

FAB:	101820996(PDGFRA)

OMA:	130252678(PDGFRA)

PHI:	102113476(PDGFRA)

PMAJ:

107203533(PDGFRA)

CCAE:

111928019(PDGFRA)

CCW:	104690630(PDGFRA)

CBRC:

103622463(PDGFRA)

ACOE:

138109842(PDGFRA)

ETL:	114058301(PDGFRA)

ZAB:	102070900 102075453(PDGFRA)

ZLE:	135446528(PDGFRA)

ACHL:

103803982(PDGFRA)

SVG:	106851489(PDGFRA)

MMEA:

130573943(PDGFRA)

HRT:	120753384(PDGFRA)

SATI:

136360061(PDGFRA)

CFAI:

136291087(PDGFRA)

CCIC:

134043952(PDGFRA)

FPG:	101913531(PDGFRA)

FCH:	102054310(PDGFRA)

CCRI:

104158694(PDGFRA)

NNT:	104404822(PDGFRA)

SHAB:

115611017(PDGFRA)

ACUN:

113479434(PDGFRA)

SURA:

141942602(PDGFRA)

TALA:

104362833(PDGFRA)

ACHC:

115341064(PDGFRA)

HALD:

104323103(PDGFRA)

HLE:	104836128(PDGFRA)

AGEN:

126051775

HHAR:

128138705(PDGFRA)

BBUT:

142030200(PDGFRA)

GCL:

127015473

CSTI:

104563475(PDGFRA)

LDI:	104352929(PDGFRA)

MNB:	103778913(PDGFRA)

DPUB:

104299132(PDGFRA)

PPUS:

135178369(PDGFRA)

AVIT:

104273942(PDGFRA)

BRHI:

104498042(PDGFRA)

EGZ:	104129386(PDGFRA)

NNI:	104020776(PDGFRA)

PCRI:

104033607(PDGFRA)

PCAO:

104042646(PDGFRA)

PADL:

103926287(PDGFRA)

AFOR:

103897403(PDGFRA)

FGA:	104075470(PDGFRA)

CBOR:

142081849(PDGFRA)

GSTE:

104264045(PDGFRA)

CBOY:

140651699(PDGFRA)

MAME:

142409062(PDGFRA)

CLV:	102087625(PDGFRA)

CNIC:

135988112(PDGFRA)

MUI:	104544483(PDGFRA)

PGUU:

104462640(PDGFRA)

PLET:

104623117(PDGFRA)

EHS:	104509161(PDGFRA)

CMAC:

104485376(PDGFRA)

CUCA:

104067138(PDGFRA)

TEO:	104374063(PDGFRA)

BREG:

104639315(PDGFRA)

GAME:

129205755(PDGFRA)

OHA:	104334893(PDGFRA)

ACAR:

104526681(PDGFRA)

CPEA:

104393038(PDGFRA)

CVF:	104286392(PDGFRA)

RTD:	128910230(PDGFRA)

CRID:

134516356(PDGFRA)

LMIC:

141743573(PDGFRA)

NARQ:

141469591(PDGFRA)

AAM:	106490172(PDGFRA)

AROW:

112974613(PDGFRA)

NPD:	112942568(PDGFRA)

DNE:	112979490(PDGFRA)

SCAM:

104139531(PDGFRA)

ASN:	102378120(PDGFRA)

AMJ:	102575338(PDGFRA)

CPOO:

109322084(PDGFRA)

GGN:	109303887(PDGFRA)

PSS:	102443708(PDGFRA)

CIZ:	142012496(PDGFRA)

CMY:	102935642(PDGFRA)

CCAY:

125635912(PDGFRA)

LKP:	140910620(PDGFRA)

NDS:	141986656(PDGFRA)

DCC:	119854364(PDGFRA)

CPIC:

101935558(PDGFRA)

TST:	117878037(PDGFRA)

CABI:

116821225(PDGFRA)

MRV:	120407146(PDGFRA)

ACS:	100565834(pdgfra)

ASAO:

132776647(PDGFRA)

PVT:	110078407(PDGFRA)

SUND:

121930753(PDGFRA)

PBI:	103067713(PDGFRA)

PMUR:

107298631(PDGFRA)

CTIG:

120316828(PDGFRA)

PGUT:

117662144(PDGFRA)

PCAE:

139320570(PDGFRA)

APRI:

131202829(PDGFRA)

PTEX:

113435807(PDGFRA)

NSS:	113422760(PDGFRA)

VKO:	123016964(PDGFRA)

PMUA:

114604335(PDGFRA)

PRAF:

128421512(PDGFRA)

ZVI:	118083576(PDGFRA)

HCG:	128328379(PDGFRA)

GJA:	107106036(PDGFRA)

STOW:

125440368(PDGFRA)

EMC:	129336443(PDGFRA)

XLA:	108706592(pdgfra.S) 380245(pdgfra.L)

XTR:	100124862(pdgfra)

NPR:	108804111(PDGFRA)

RTEM:

120922903(PDGFRA)

ACAT:

141115002(PDGFRA)

PADS:

140327071(PDGFRA)

BBUF:

120990209(PDGFRA)

BGAR:

122941740(PDGFRA)

DTC:	141096762(PDGFRA)

PWL:	138246516(PDGFRA)

MUO:	115461528(PDGFRA)

GSH:	117360846(PDGFRA)

DRE:	386856(pdgfra)

SRX:	107718396 107755213

SANH:

107665286 107683957

SGH:	107597438 107601905

CCAR:

109113014

CAUA:

113063319 113078680 113120986

CGIB:

127938096 127984263

PTET:

122325140(pdgfra) 122325223

LROH:

127183147(pdgfra)

GRF:	141283159(pdgfra)

OMC:	131527390(pdgfra)

PPRM:

120493762(pdgfra)

RKG:	130097535(pdgfra)

MAMB:

125277998(pdgfra)

CIDE:

127502375

CERY:

137018885(pdgfra)

MASI:

127410197 127416231

TROS:

130566360(pdgfra)

TDW:	130434670(pdgfra)

MANU:

129428961(pdgfra)

PDAB:

135738946(pdgfra)

IPU:

108258040

IFU:	128601293(pdgfra)

PHYP:

113546841(pdgfra)

SMEO:

124377156(pdgfra)

TFD:	113642582(pdgfra)

TVC:	132843456(pdgfra)

CGAR:

128514768(pdgfra)

NGRA:

132883591(pdgfra)

TRN:	134320610(pdgfra)

AMEX:

103044267(pdgfra)

CMAO:

118815384(pdgfra)

EEE:	113586382(pdgfra)

CHAR:

105895070(pdgfra)

SPIL:

134102833(pdgfra)

ASAD:

121677847(pdgfra)

TRU:	101073543(pdgfra)

TFS:	130528831(pdgfra)

TNG:	GSTEN00032764G001

LCO:	104919088(pdgfra)

NCC:	104947073(pdgfra)

TBEN:

117495114(pdgfra)

CGOB:

115006742(pdgfra)

PGEO:

117445902(pdgfra)

GACU:

117555073(pdgfra)

EMAC:

134869964(pdgfra)

ELY:	117253552(pdgfra)

EFO:	125895404(pdgfra)

PLEP:

121940421(pdgfra)

SLUC:

116058814(pdgfra)

ECRA:

117950139(pdgfra)

ESP:	116695589(pdgfra)

PFLV:

114561192(pdgfra)

GAT:	120824143(pdgfra)

PPUG:

119216932(pdgfra)

AFB:	129094441(pdgfra)

CLUM:

117730130(pdgfra)

PSWI:

130193912(pdgfra)

CANA:

137795394(pdgfra)

CVE:	137883736(pdgfra)

MSAM:

119901064(pdgfra)

SCHU:

122877458(pdgfra)

EARM:

139288273(pdgfra)

CUD:	121512171(pdgfra)

SPUL:

138607231(pdgfra)

LMIX:

132955920(pdgfra)

HTC:	141789309(pdgfra)

ALAT:

119028306(pdgfra)

ASTR:

137598419(pdgfra)

PKLU:

139202430(pdgfra)

MZE:	101471693(pdgfra)

ONL:	100692594(pdgfra)

OAU:	116331096(pdgfra)

OLA:	100049280(pdgfra)

OML:	112137012(pdgfra)

CSAI:

133458269(pdgfra)

XMA:	102219876(pdgfra)

XCO:	114151105(pdgfra)

XHE:	116726146(pdgfra)

PRET:

103463840(pdgfra)

PFOR:

103137117(pdgfra)

PLAI:

106963502(pdgfra)

PMEI:

106924185(pdgfra)

GAF:	122838005(pdgfra)

PPRL:

129369979(pdgfra)

CVG:	107091563(pdgfra)

CTUL:

119780613(pdgfra)

GMU:	124873707(pdgfra)

NFU:	107393382(pdgfra)

KMR:	108243392(pdgfra)

ALIM:

106524096(pdgfra)

NWH:	119430861(pdgfra)

AOCE:

111569607(pdgfra)

EJA:	138198925(pdgfra)

BFRE:

138621302(pdgfra)

MCEP:

125009234(pdgfra)

CSEM:

103376707(pdgfra)

POV:	109625664(pdgfra)

SSEN:

122780311(pdgfra)

SSOE:

131466137(pdgfra)

HHIP:

117760248(pdgfra)

HSP:	118121006(pdgfra)

PPLT:

128448052(pdgfra)

SMAU:

118317851(pdgfra)

LCF:

108879100

SDU:	111226338(pdgfra)

SLAL:

111644345(pdgfra)

XGL:	120790742(pdgfra)

HCQ:	109532287(pdgfra)

SSCV:

125976148(pdgfra)

SBIA:

133503119(pdgfra)

PEE:	133406249(pdgfra)

PTAO:

133480405(pdgfra)

BPEC:

110154688(pdgfra)

ENY:	140353531(pdgfra)

MALB:

109962087(pdgfra)

BSPL:

114854622(pdgfra)

SJO:	128361361(pdgfra)

SSCO:

133984808(pdgfra)

TTY:	137188140(pdgfra)

GMH:	115555724(pdgfra)

SASA:

106560269 106584117(pdgfra)

STRU:

115158529 115192386

OTW:	112249110(pdgfra) 112251129

OMY:	110521671(pdgfra) 110523003

OGO:	123996500 124037857(pdgfra)

ONE:	115108534 115145127(pdgfra)

OKI:	109898025(pdgfra) 109902718

OKE:	118358652(pdgfra) 118380692

OMM:	135513010 135556309(pdgfra)

OCLA:

139406699 139409366

SALP:

111972315(pdgfra) 111976174

SNH:	120052582(pdgfra) 120054283

SFON:

129855389(pdgfra) 129869626

CCLU:

121533963 121540157(pdgfra)

ELS:	105011836(pdgfra)

OEP:	134011035(pdgfra)

SFM:	108922803(pdgfra)

PKI:

111850064

AANG:

118225723(pdgfra)

AROT:

135254039(pdgfra)

CCOG:

133120479(pdgfra)

LOC:	102682229(pdgfra)

PSPA:

121298148 121320036

ARUT:

117408343 117420605

PSEX:

120527608(pdgfra)

LCM:	102353753(PDGFRA)

CMK:	103178167(pdgfra)

RTP:	109927411(pdgfra)

CPLA:

122550155(pdgfra)

CPUN:

140476619(pdgfra)

HOC:	132815312(pdgfra)

SCAU:

119962911(pdgfra)

LERI:

129697462(pdgfra)

HAKA:

140737887(pdgfra)

PMRN:

116939357 116942836

LRJ:	133342875 133346943 133346982

CGLO:

DMK:

PCHN:

DFR:

NVE:

EPA:	110240437 110244533

PDAM:

113683455

SPIS:

111322907 111344410

» show all

Reference

PMID:2544881

Authors

Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH

Title

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

Journal

Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917

Sequence

[hsa:5156]

Reference

PMID:8188664

Authors

Vassbotn FS, Havnen OK, Heldin CH, Holmsen H

Title

Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.

Journal

J Biol Chem 269:13874-9 (1994)

Sequence

[hsa:5156]

LinkDB

ORTHOLOGY: K05087

Entry

K05087                      KO

Symbol

IGF1R, CD221

Name

insulin-like growth factor 1 receptor [EC:2.7.10.1]

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04066

HIF-1 signaling pathway

map04068

FoxO signaling pathway

map04081

Hormone signaling

map04114

Oocyte meiosis

map04140

Autophagy - animal

map04144

Endocytosis

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04213

Longevity regulating pathway - multiple species

map04510

Focal adhesion

map04520

Adherens junction

map04550

Signaling pathways regulating pluripotency of stem cells

map04730

Long-term depression

map04913

Ovarian steroidogenesis

map04914

Progesterone-mediated oocyte maturation

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05205

Proteoglycans in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05224

Breast cancer

map05225

Hepatocellular carcinoma

Disease

H00015

Malignant pleural mesothelioma

H00048

Hepatocellular carcinoma

H00050

Synovial sarcoma

H01274

Growth delay due to insulin-like growth factor I resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04014 Ras signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04150 mTOR signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04140 Autophagy - animal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09156 Nervous system
   04730 Long-term depression
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09149 Aging
   04211 Longevity regulating pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04213 Longevity regulating pathway - multiple species
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05224 Breast cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   01522 Endocrine resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor

Other DBs

GO:	0005010 0031994

Genes

HSA:	3480(IGF1R)

PTR:	453676(IGF1R)

PPS:	100981083(IGF1R)

GGO:	101154546(IGF1R)

PON:	100172156(IGF1R)

PPYG:

129013948(IGF1R)

NLE:	100593288(IGF1R)

HMH:	116482110(IGF1R)

SSYN:

129482009(IGF1R)

MCC:	708227(IGF1R)

MCF:	102130142(IGF1R)

MTHB:

126959327

MNI:	105479398(IGF1R)

CSAB:

103231259(IGF1R)

CATY:

105594004(IGF1R)

PANU:

100126735(IGF1R)

TGE:	112628505(IGF1R)

MLEU:

105531828(IGF1R)

RRO:	104677192(IGF1R)

RBB:	108538668(IGF1R)

TFN:	117070145(IGF1R)

PTEH:

111548389(IGF1R)

CANG:

105523056(IGF1R)

CJC:	100408399(IGF1R)

SBQ:	101039763(IGF1R)

CIMI:

108294997(IGF1R)

ANAN:

105707635(IGF1R)

CSYR:

103257652(IGF1R)

MMUR:

105871266(IGF1R)

LCAT:

123645036(IGF1R)

ERUF:

138381495(IGF1R)

PCOQ:

105809892(IGF1R)

OGA:	100944394(IGF1R)

MMU:	16001(Igf1r)

MCAL:

110297825(Igf1r)

MPAH:

110324292(Igf1r)

RNO:	25718(Igf1r)

MCOC:

116102373(Igf1r)

ANU:	117715978(Igf1r)

ASYL:

127667679(Igf1r)

MUN:	110547261(Igf1r)

CGE:	100768531(Igf1r)

MAUA:

101825606(Igf1r)

PROB:

127238044(Igf1r)

PLEU:

114695462(Igf1r)

PMAV:

102917869(Igf1r)

MORG:

121453621(Igf1r)

MFOT:

126505922

AAMP:

119802616(Igf1r)

CNL:	130865066(Igf1r)

NGI:	103749467(Igf1r)

HGL:	101710224(Igf1r)

CPOC:

100734840(Igf1r)

CCAN:

109687530

DORD:

105982453(Igf1r)

DSP:	122123999(Igf1r)

DMER:

138842038(Igf1r)

PLOP:

125368530(Igf1r)

NCAR:

124978062

MMMA:

107148359(Igf1r)

ITI:	101960744(Igf1r)

OCU:

100144342

OPI:	101535483(IGF1R)

OCZ:	121148868(IGF1R)

TUP:	102473496(IGF1R)

GVR:	103595208(IGF1R)

CFA:	442951(IGF1R)

CLUD:

112653816(IGF1R)

VVP:	112922150(IGF1R)

VLG:	121490029(IGF1R)

NPO:	129510268(IGF1R)

AML:	100471374(IGF1R)

UMR:	103660044(IGF1R)

UAH:	113263646(IGF1R)

UAR:	123790797(IGF1R)

ELK:

111152643

LLV:

125105350

MPUF:

101681935(IGF1R)

MNP:	131999088(IGF1R)

MLK:	131835676(IGF1R)

NVS:	122893272(IGF1R)

ORO:	101386211(IGF1R)

EJU:	114223793(IGF1R)

ZCA:	113909166(IGF1R)

MLX:	118023006(IGF1R)

NSU:	110572370(IGF1R)

LWW:

102731850

FCA:	100500937(IGF1R)

PYU:	121042474(IGF1R)

PCOO:

112855479(IGF1R)

PBG:	122468290(IGF1R)

PVIV:

125167768(IGF1R)

LRUF:

124517265

LGF:	123582544(IGF1R)

AJU:

106975144

PTG:	102949680(IGF1R)

PPAD:

109273360(IGF1R)

PUC:

125910252

PLEZ:

122221672(IGF1R)

HHV:	120233674(IGF1R)

BTA:	281848(IGF1R)

BOM:	102278105(IGF1R)

BIU:

109575129

BBUB:

102403092(IGF1R)

BKE:	129634393(IGF1R)

BBIS:

104992840(IGF1R)

CHX:	100861165(IGF1R)

OAS:	443515(IGF1R)

BTAX:

128066571(IGF1R)

CSUM:

138094861(IGF1R)

ODA:	120875257(IGF1R)

CCAD:

122454848(IGF1R)

MREE:

136147032(IGF1R)

OVR:	110148753(IGF1R)

MBEZ:

129550230(IGF1R)

SSC:	397350(IGF1R)

CFR:	102524338(IGF1R)

CBAI:

105075161(IGF1R)

CDK:	105093441(IGF1R)

VPC:	102535933(IGF1R)

BACU:

103015537(IGF1R)

BMUS:

118890679(IGF1R)

LVE:	103081291(IGF1R)

OOR:	101281976(IGF1R)

LALB:

132523918(IGF1R)

GMF:	115861920(IGF1R)

DDP:	132420760(IGF1R)

DLE:	111187347(IGF1R)

PCAD:

102977826(IGF1R)

PSIU:

116748753(IGF1R)

PPHC:

136118169(IGF1R)

NASI:

112390977(IGF1R)

ECB:	100055698(IGF1R)

EPZ:	103559577(IGF1R)

EAI:	106836604(IGF1R)

MYB:	102253516(IGF1R)

MYD:	102770795(IGF1R)

MMYO:

118679204(IGF1R)

MLF:	102430595(IGF1R)

MDT:	132222850(IGF1R)

MYUM:

138998477(IGF1R)

PKL:	118704316(IGF1R)

EFUS:

103301950(IGF1R)

MNA:	107527774(IGF1R)

DRO:	112306076(IGF1R)

SHON:

118992013(IGF1R)

AJM:	119049802(IGF1R)

PDIC:

114488551(IGF1R)

PHAS:

123809769(IGF1R)

MMF:	118640813(IGF1R)

PPAM:

129061268(IGF1R)

HAI:	109380372(IGF1R)

RFQ:	117018797(IGF1R)

PALE:

102885962(IGF1R)

PGIG:

120587362(IGF1R)

PVP:	105290270(IGF1R)

RAY:	107509347(IGF1R)

MJV:

108403280

TOD:	119245137(IGF1R)

SARA:

101549049(IGF1R)

SFUM:

130033143(IGF1R)

SETR:

126021814(IGF1R)

LAV:	100655087(IGF1R)

TMU:

101355333

ETF:	101643319(IGF1R)

DNM:	101416767(IGF1R)

MDO:	100020095(IGF1R)

GAS:	123238083(IGF1R)

SHR:	100916673(IGF1R)

AFZ:

127551347

PCW:	110192705(IGF1R)

TVP:	118828007(IGF1R)

PBRV:

138169220(IGF1R)

MLAO:

141521535(IGF1R)

OAA:	100077556(IGF1R)

TACU:

119928193(IGF1R)

GGA:	395889(IGF1R)

PCOC:

116225423(IGF1R)

MGP:	100539720(IGF1R)

CJO:	107318870(IGF1R)

TPAI:

128075328(IGF1R)

LMUT:

125698369(IGF1R)

NMEL:

110403525(IGF1R)

APLA:

101802018(IGF1R)

AACU:

137863005(IGF1R)

ACYG:

106036418(IGF1R)

CATA:

118251997(IGF1R)

AFUL:

116493472(IGF1R)

TGU:	100227374(IGF1R)

LSR:	110482986(IGF1R)

SCAN:

103816222(IGF1R)

PMOA:

120508810(IGF1R)

OTC:	121343296(IGF1R)

PRUF:

121354271(IGF1R)

ATRC:

139596755(IGF1R)

GFR:	102036037(IGF1R)

FAB:	101819893(IGF1R)

OMA:	130257330(IGF1R)

PHI:	102103364(IGF1R)

PMAJ:

107209439(IGF1R)

CCAE:

111933868(IGF1R)

CCW:	104684080(IGF1R)

CBRC:

103619295(IGF1R)

ACOE:

138116669(IGF1R)

ETL:	114054644(IGF1R)

ZAB:	102066292(IGF1R)

ZLE:	135452032(IGF1R)

ACHL:

103798238(IGF1R)

SVG:	106852146(IGF1R)

MMEA:

130578912(IGF1R)

HRT:	120758822(IGF1R)

SATI:

136366952(IGF1R)

CFAI:

136297039(IGF1R)

CCIC:

134049386(IGF1R)

FPG:	101914715(IGF1R)

FCH:	102046128(IGF1R)

CCRI:

104161223(IGF1R)

NNT:	104402233(IGF1R)

SHAB:

115612454(IGF1R)

ACUN:

113483985(IGF1R)

SURA:

141948066(IGF1R)

TALA:

104359828(IGF1R)

ACHC:

115341184(IGF1R)

HALD:

104317439(IGF1R)

HLE:	104834576(IGF1R)

AGEN:

126043427

HHAR:

128151507(IGF1R)

BBUT:

142038979(IGF1R)

GCL:

127020876

CSTI:

104550485(IGF1R)

LDI:

104352591

MNB:	103776523(IGF1R)

DPUB:

104298885(IGF1R)

PPUS:

135183148(IGF1R)

AVIT:

104273657(IGF1R)

BRHI:

104492992(IGF1R)

EGZ:	104122851(IGF1R)

NNI:	104017228(IGF1R)

PCRI:

104034958(IGF1R)

PCAO:

104039385(IGF1R)

PADL:

103914830(IGF1R)

AFOR:

103900344(IGF1R)

FGA:	104078904(IGF1R)

CBOR:

142086624(IGF1R)

GSTE:

104263004(IGF1R)

CBOY:

140655648(IGF1R)

MAME:

142411795(IGF1R)

CLV:	102089963(IGF1R)

CNIC:

135992360(IGF1R)

MUI:	104541385(IGF1R)

PGUU:

104461336(IGF1R)

PLET:

104621030(IGF1R)

EHS:	104510387(IGF1R)

CMAC:

104485700(IGF1R)

CUCA:

104062934(IGF1R)

TEO:	104375651(IGF1R)

BREG:

104636598(IGF1R)

GAME:

129210823(IGF1R)

OHA:	104339317(IGF1R)

ACAR:

104528088(IGF1R)

CPEA:

104386703(IGF1R)

CVF:	104288725(IGF1R)

RTD:	128915086(IGF1R)

CRID:

134520272(IGF1R)

LMIC:

141748684(IGF1R)

NARQ:

141470408(IGF1R)

AAM:	106485327(IGF1R)

AROW:

112970160(IGF1R)

NPD:	112948275(IGF1R)

TGT:	104574034(IGF1R)

DNE:	112996278(IGF1R)

SCAM:

104148380(IGF1R)

ASN:	102387852(IGF1R)

AMJ:	106736787(IGF1R)

CPOO:

109309154(IGF1R)

GGN:	109288473(IGF1R)

PSS:	102455576(IGF1R)

CIZ:	142019747(IGF1R)

CMY:	102941686(IGF1R)

CCAY:

125643327(IGF1R)

LKP:	140895067(IGF1R)

NDS:	141995370(IGF1R)

DCC:	119862152(IGF1R)

CPIC:

101952328(IGF1R)

TST:	117884524(IGF1R)

CABI:

116826364(IGF1R)

MRV:	120372851(IGF1R)

ACS:	100554064(igf1r)

ASAO:

132762556(IGF1R)

PVT:	110072986(IGF1R)

SUND:

121933049(IGF1R)

PBI:	103049336(IGF1R)

PMUR:

107290589(IGF1R)

CTIG:

120316466(IGF1R)

TSR:	106545511(IGF1R) 106555187

PGUT:

117676169(IGF1R)

PCAE:

139324154(IGF1R)

APRI:

131184878(IGF1R)

PTEX:

113442022(IGF1R)

NSS:	113415602(IGF1R)

VKO:	123030778(IGF1R)

PMUA:

114584984(IGF1R)

PRAF:

128401604(IGF1R)

ZVI:	118092682(IGF1R)

HCG:	128334748(IGF1R)

GJA:	107121607(IGF1R)

STOW:

125424423(IGF1R)

EMC:	129345172(IGF1R)

XLA:	108711478(igf1r.L) 398022(igf1r.S)

XTR:	100329112(igf1r)

NPR:	108787513(IGF1R)

RTEM:

120931158(IGF1R)

ACAT:

141131277(IGF1R)

PADS:

140324625(IGF1R)

BBUF:

120985975(IGF1R)

BGAR:

122927524(IGF1R)

DTC:	141084228(IGF1R)

PWL:	138284231(IGF1R)

MUO:	115459902(IGF1R)

GSH:	117348218(IGF1R)

DRE:	245701(igf1ra) 245702(igf1rb)

SRX:	107706937 107708213 107738680 107741044

SANH:

107660938 107672255 107674748

SGH:	107583745 107594738 107596941

CCAR:

109059319 109079742 109095255 109104460

CAUA:

113051989 113070226 113102096 113105560 113118396

CGIB:

127934765 127961315 127977570 128017328

PTET:

122349311(igf1rb) 122363083(igf1ra)

LROH:

127167905(igf1rb) 127180463(igf1ra)

GRF:	141331378(igf1rb)

OMC:	131524230(igf1ra) 131543547(igf1rb)

PPRM:

120469797(igf1rb) 120487871(igf1ra)

RKG:	130088147(igf1ra) 130091356(igf1rb)

MAMB:

125253737(igf1ra) 125264449(igf1rb)

CIDE:

127500363 127516213

CERY:

137023373(igf1ra) 137030840(igf1rb)

MASI:

127413273 127416888 127444755 127455660

TROS:

130552567(igf1rb) 130563103(igf1ra)

TDW:	130417899(igf1rb) 130435165(igf1ra)

MANU:

129418564(igf1ra) 129420648(igf1rb)

PDAB:

135773557(igf1ra) 135783470(igf1rb)

IPU:	100304999(igf1ra) 108271091(igf1rb)

IFU:	128606740(igf1ra) 128613996(igf1rb)

PHYP:

113534424(igf1r) 113536568

SMEO:

124391334(igf1rb) 124396130(igf1ra)

TFD:	113652381(igf1ra) 113653192(igf1rb)

TVC:	132851207(igf1ra) 132855624(igf1rb)

CGAR:

128527739(igf1ra) 128542759(igf1rb)

NGRA:

132888024(igf1ra) 132899292(igf1rb)

TRN:	134322787(igf1ra) 134331539(igf1rb)

AMEX:

103037538(igf1ra) 103045439(igf1rb)

CMAO:

118818325(igf1ra) 118819471(igf1rb)

EEE:	113573593 113586501

CHAR:

105893090 105904485(igf1ra)

SPIL:

134068734 134093870(igf1ra)

ASAD:

121694719 121723688

TRU:	101063427 101079603

TFS:	130514606 130535722(igf1ra)

TNG:	GSTEN00022424G001 GSTEN00035595G001

LCO:	104920736(igf1r) 104921706

TBEN:

117491654(igf1ra) 117497008

CGOB:

115009816(igf1r)

PGEO:

117448090(igf1ra)

GACU:

117541527 117557655(igf1ra)

EMAC:

134863593(igf1rb) 134876718(igf1ra)

ELY:	117253608 117261726(igf1ra)

EFO:	125887452(igf1ra) 125901306

PLEP:

121941149(igf1rb) 121949679(igf1ra)

SLUC:

116045678(igf1ra) 116057296

ECRA:

117945857(igf1rb) 117948865(igf1ra)

ESP:	116694009 116694654

PFLV:

114560454 114560702

GAT:	120809290 120812613 120812690 120832004(igf1rb)

PPUG:

119195567(igf1ra) 119198402(igf1rb)

AFB:	129107750(igf1ra) 129108015

CLUM:

117727293(igf1rb) 117732564(igf1ra)

PSWI:

130192406(igf1rb) 130194898(igf1ra)

CANA:

137785445(igf1rb) 137804342(igf1ra)

CVE:	137881047(igf1ra) 137887826

MSAM:

119889848(igf1rb) 119894125(igf1ra)

SCHU:

122874941(igf1rb) 122875174(igf1ra)

EARM:

139283223(igf1rb) 139286459(igf1ra)

CUD:	121507367 121514568(igf1ra)

SPUL:

138593569(igf1rb) 138612488(igf1ra)

LMIX:

132972432(igf1ra) 132979534

HTC:	141788322(igf1rb) 141796115(igf1ra)

ALAT:

119017814 119023710(igf1ra)

ASTR:

137592034(igf1rb) 137593370(igf1ra)

PKLU:

139202027(igf1ra) 139216830

MZE:	101469217 101479543(igf1r)

ONL:	100707581 100711993

OAU:	116313500 116325617(igf1rb)

OLA:	101163560 101173298

OML:	112152311(igf1ra) 112160640(igf1rb)

CSAI:

133444270(igf1ra) 133464921

XMA:	102221045 102235279

XCO:	114143064 114157257

XHE:	116718570 116732888

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122822814 122835010(igf1ra)

PPRL:

129361114(igf1ra) 129364100

CVG:	107087242(igf1r) 107097409

CTUL:

119772423 119797368

GMU:	124866795 124885065(igf1ra)

NFU:	107382005 107388825

KMR:	108230129(igf1ra) 108243323(igf1rb)

ALIM:

106514315 106531111(igf1r)

NWH:	119416283(igf1ra) 119423732(igf1rb)

AOCE:

111571920(igf1ra) 111587416(igf1rb)

EJA:	138206678(igf1ra) 138213361

BFRE:

138616197 138628200(igf1ra)

MCEP:

125005277(igf1rb) 125014422(igf1ra)

CSEM:

103379307

POV:	109624556 109625052(igf1r)

SSEN:

122772252 122775584(igf1ra)

SSOE:

131459214(igf1rb) 131470523(igf1ra)

HHIP:

117754056(igf1rb) 117763797(igf1ra)

HSP:	118109282(igf1ra) 118122842(igf1rb)

PPLT:

128444047(igf1ra) 128444947

SMAU:

118302144(igf1rb) 118314741(igf1ra)

LCF:	108875244(igf1ra) 108897720(igf1rb)

SDU:	111217738 111228731

SLAL:

111653328 111672288

XGL:	120790593 120793054(igf1ra)

HCQ:	109513166 109513874(igf1r)

SSCV:

125966666(igf1rb) 125971071

SBIA:

133498213(igf1rb) 133502174

PEE:	133398212(igf1rb) 133403348(igf1ra)

PTAO:

133474106(igf1rb) 133478285(igf1ra)

BPEC:

110169184 110175503

ENY:	140381418(igf1rb)

MALB:

109966709 109969948

BSPL:

114852027(igf1rb) 114856925(igf1ra)

SJO:	128356204(igf1rb) 128358344(igf1ra)

SSCO:

133981457(igf1ra) 134001970(igf1rb)

TTY:	137182993(igf1ra) 137186661(igf1rb)

GMH:	115550548 115558480

SASA:

100194499(igf1r) 106573762 106588078

STRU:

115151978 115182685 115196778 115203659

OTW:	112218557(igf1ra) 112224871 112252377

OMY:	100135872(igf1ra) 110516588 110518867 110520661

OGO:	124000795 124036813(igf1ra)

ONE:	115109402 115134267

OKI:	109867238 109886095 109886841 109889344

OKE:	118396693(igf1ra) 118401242

OMM:	135509368(igf1ra) 135524404 135554301

OCLA:

139371644 139384630 139394389 139394411 139400755

SALP:

111952526 111962390(igf1r)

SNH:	120053452 120065838(igf1ra)

SFON:

129834827 129862483(igf1ra) 129867073

CCLU:

121531890(igf1ra) 121555650 121576630

ELS:	105016672 105023472(igf1r)

OEP:	134021149(igf1ra) 134028545

SFM:	108926605(igf1r) 108941092

PKI:	111845000(igf1r) 111845734

AANG:

118215508(igf1ra) 118227904

AROT:

135241874(igf1ra) 135254961

CCOG:

133112114(igf1ra) 133130240

LOC:	102690467(igf1r)

PSPA:

121294410 121298882(igf1ra)

ARUT:

117427860 117963120

PSEX:

120541537

LCM:	102367342(IGF1R)

CMK:	103188389(igf1ra)

RTP:	109924711(igf1ra)

CPLA:

122542552(igf1ra)

CPUN:

140458406(igf1ra)

HOC:	132834684(igf1ra)

SCAU:

119956901(igf1ra)

LERI:

129713499(igf1ra)

HAKA:

140714363(igf1ra)

PMRN:

116939503

LRJ:

133346605

DME:	Dmel_CG18402(InR)

DER:

6553414

DSE:

6614334

DSI:	Dsimw501_GD19971(Dsim_GD19971)

DYA:	Dyak_GE24970

DSR:

DPO:

DPE:

DMN:

DWI:	6647111 6647336

DGR:	6563200 6567180

DMO:	Dmoj_GI23836

DAZ:

108621684

DNV:	108660316 108660354

DHE:	111599590 111600855 115483782

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135949326(InR)

GFS:	119643360 119644342 119644348

ECOE:

CLON:

SOY:

AGRG:

CSET:

HAXR:

AGB:

PPYR:

OTU:

MSEX:

BANY:

PRAP:

LSIN:

HAW:

TNL:

SLIU:

CCRN:

HVI:

MQU:

FOC:

PCHN:

HAME:

PCLA:

PTRU:

123499223 123502764 123503709

ESN:

MNZ:

MRJ:

PORN:

RMP:

TSP:

BARL:

EGL:	EGR_02146 EGR_02635

DGT:	114519777 114534122

HMG:

100214733

SRE:	PTSG_12766

» show all

Reference

PMID:8257688

Authors

Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y

Title

Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.

Journal

Biochemistry 32:13531-6 (1993)
DOI:10.1021/bi00212a019

Sequence

[hsa:3480]

Reference

PMID:2877871

Authors

Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al.

Title

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

Journal

EMBO J 5:2503-12 (1986)
DOI:10.1002/j.1460-2075.1986.tb04528.x

Sequence

[hsa:3480]

Reference

PMID:11498020

Authors

Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA

Title

Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.

Journal

Biochem Soc Trans 29:513-25 (2001)
DOI:10.1042/bst0290513

LinkDB

ORTHOLOGY: K05089

Entry

K05089                      KO

Symbol

PDGFRB, CD140B

Name

platelet-derived growth factor receptor beta [EC:2.7.10.1]

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map05165

Human papillomavirus infection

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05230

Central carbon metabolism in cancer

map05231

Choline metabolism in cancer

Disease

H00042

Glioma

H01574

Familial idiopathic basal ganglia calcification

H01910

Infantile myofibromatosis

H02870

Premature aging syndrome, Penttinen type

H02872

Kosaki overgrowth syndrome

H02928

Ocular pterygium-digital keloid dysplasia syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 JAK-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09162 Cancer: specific types
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide

Other DBs

GO:

0004992

Genes

HSA:	5159(PDGFRB)

PTR:	462188(PDGFRB)

PPS:	100975853(PDGFRB)

GGO:	101150577(PDGFRB)

PON:	100460001(PDGFRB)

PPYG:

129036804(PDGFRB)

NLE:	100597894(PDGFRB)

HMH:	116471711(PDGFRB)

SSYN:

129486167(PDGFRB)

MCC:	711353(PDGFRB)

MCF:	101867161(PDGFRB)

MTHB:

126956582

MNI:	105466873(PDGFRB)

CSAB:

103244790(PDGFRB)

CATY:

105589876(PDGFRB)

PANU:

101008264(PDGFRB)

TGE:	112626117(PDGFRB)

MLEU:

105543434(PDGFRB)

RRO:	104670408(PDGFRB)

RBB:	108532047(PDGFRB)

TFN:	117065596(PDGFRB)

PTEH:

111552670(PDGFRB)

CANG:

105504227(PDGFRB)

CJC:	100389852(PDGFRB)

SBQ:	101040158(PDGFRB)

CIMI:

108306401(PDGFRB)

ANAN:

105716781(PDGFRB)

CSYR:

103263367(PDGFRB)

MMUR:

105858450(PDGFRB)

LCAT:

123638073(PDGFRB)

ERUF:

138392964(PDGFRB)

PCOQ:

105821582(PDGFRB)

OGA:	100951606(PDGFRB)

MMU:	18596(Pdgfrb)

MCAL:

110284880(Pdgfrb)

MPAH:

110333065(Pdgfrb)

RNO:	24629(Pdgfrb)

MCOC:

116087226(Pdgfrb)

ANU:	117719688(Pdgfrb)

ASYL:

127663737(Pdgfrb)

MUN:	110546695(Pdgfrb)

CGE:	100764374(Pdgfrb)

MAUA:

101840188(Pdgfrb)

PROB:

127234263(Pdgfrb)

PLEU:

114707365(Pdgfrb)

PMAV:

102915075(Pdgfrb)

MORG:

121440622(Pdgfrb) 121445248

MFOT:

126511093

AAMP:

119815474(Pdgfrb)

CNL:	130886771(Pdgfrb)

NGI:	103747076(Pdgfrb)

HGL:	101721151(Pdgfrb)

CPOC:

100726506(Pdgfrb)

CCAN:

109685664(Pdgfrb)

DORD:

105992616(Pdgfrb)

DSP:	122118168(Pdgfrb)

DMER:

138837498(Pdgfrb)

PLOP:

125339985(Pdgfrb)

NCAR:

124986803

MMMA:

107154281(Pdgfrb)

ITI:	101964547(Pdgfrb)

OCU:

100342872

OPI:	101516431(PDGFRB)

OCZ:	121154145(PDGFRB)

TUP:	102492413(PDGFRB)

GVR:	103585042(PDGFRB)

CFA:	442985(PDGFRB)

CLUD:

112651939(PDGFRB)

VVP:	112927357(PDGFRB)

VLG:	121486777(PDGFRB)

NPO:	129509546(PDGFRB)

AML:	100472005(PDGFRB)

UMR:	103664600(PDGFRB)

UAH:	113263944(PDGFRB)

UAR:	123803639(PDGFRB)

ELK:

111140848

LLV:

125100170

MPUF:

101684361(PDGFRB)

MNP:	132028321(PDGFRB)

MLK:	131831763(PDGFRB)

NVS:	122894113(PDGFRB)

ORO:	101374793(PDGFRB)

EJU:	114211916(PDGFRB)

ZCA:	113929051(PDGFRB)

MLX:	118006692 118006827

NSU:	110586749(PDGFRB)

LWW:	102740115(PDGFRB)

FCA:	101084600(PDGFRB)

PYU:	121045013(PDGFRB)

PCOO:

112860921(PDGFRB)

PBG:	122493456(PDGFRB)

PVIV:

125166177(PDGFRB)

LRUF:

124507266

LGF:	123576400(PDGFRB)

AJU:

106985388

PTG:	102954207(PDGFRB)

PPAD:

109275948(PDGFRB)

PUC:

125934559

PLEZ:

122226329(PDGFRB)

HHV:	120236611(PDGFRB)

BTA:	527165(PDGFRB)

BOM:	102270608(PDGFRB)

BIU:	109562197(PDGFRB)

BBUB:

102392216(PDGFRB)

BKE:	129635465(PDGFRB)

BBIS:

104996312(PDGFRB)

CHX:	102184426(PDGFRB)

OAS:	101122783(PDGFRB)

BTAX:

128050429(PDGFRB)

CSUM:

138085317(PDGFRB)

ODA:	120863403(PDGFRB)

CCAD:

122439706(PDGFRB)

MREE:

136156275(PDGFRB)

OVR:	110132192(PDGFRB)

MBEZ:

129558396(PDGFRB)

SSC:	102166564(PDGFRB)

CFR:	102512951(PDGFRB)

CBAI:

105074292(PDGFRB)

CDK:	105098486(PDGFRB)

VPC:	102545129(PDGFRB)

BACU:

103019883(PDGFRB)

BMUS:

118892250(PDGFRB)

LVE:	103082363(PDGFRB)

OOR:	101272795(PDGFRB)

LALB:

132517209(PDGFRB)

GMF:	115840755(PDGFRB)

DDP:	132423151(PDGFRB)

DLE:	111183086(PDGFRB)

PCAD:

102995915(PDGFRB)

PSIU:

116751332(PDGFRB)

PPHC:

136119986(PDGFRB)

NASI:

112391109(PDGFRB)

ECB:	100071665(PDGFRB)

EPZ:	103549125(PDGFRB)

EAI:	106838493(PDGFRB)

MYB:	102241145(PDGFRB)

MYD:	102764172(PDGFRB)

MMYO:

118658697(PDGFRB)

MLF:	102441579(PDGFRB)

MDT:	132235846(PDGFRB)

MYUM:

139010325(PDGFRB)

PKL:	118711223(PDGFRB)

EFUS:

103295746(PDGFRB)

MNA:	107535230(PDGFRB)

DRO:	112319577(PDGFRB)

SHON:

118986157(PDGFRB)

AJM:	119061365(PDGFRB)

PDIC:

114509632(PDGFRB)

PHAS:

123807517(PDGFRB)

MMF:	118615300(PDGFRB)

PPAM:

129066549(PDGFRB)

HAI:	109375002(PDGFRB)

RFQ:	117016666(PDGFRB)

PALE:

102887643(PDGFRB)

PGIG:

120581545(PDGFRB)

PVP:	105299436(PDGFRB)

RAY:	107497163(PDGFRB)

MJV:	108385397(PDGFRB)

TOD:	119243270(PDGFRB)

SARA:

101540263(PDGFRB)

SFUM:

130032943(PDGFRB)

SETR:

126006402(PDGFRB)

LAV:	100671240(PDGFRB)

TMU:

101360003

ETF:	101650381(PDGFRB)

DNM:	101411552(PDGFRB)

MDO:	100028943(PDGFRB)

GAS:	123233823(PDGFRB)

SHR:	100917212(PDGFRB)

AFZ:

127550081

PCW:	110192821(PDGFRB)

TVP:	118843247(PDGFRB)

PBRV:

138172874(PDGFRB)

MLAO:

141506145(PDGFRB)

OAA:	100079459(PDGFRB)

TACU:

119950176(PDGFRB)

GGA:	770488(PDGFRB)

PCOC:

116232153(PDGFRB)

MGP:	100550611(PDGFRB)

CJO:	107320191(PDGFRB)

TPAI:

128081597(PDGFRB)

LMUT:

125700002(PDGFRB)

NMEL:

110405265(PDGFRB)

APLA:

101799587(PDGFRB)

AACU:

137864407(PDGFRB)

ACYG:

106032823(PDGFRB)

CATA:

118260560(PDGFRB)

AFUL:

116494711(PDGFRB)

TGU:	100223375(PDGFRB)

LSR:	110482721(PDGFRB)

SCAN:

103817301(PDGFRB)

PMOA:

120498517(PDGFRB)

OTC:	121332255(PDGFRB)

PRUF:

121361297(PDGFRB)

ATRC:

139597726(PDGFRB)

GFR:	102045343(PDGFRB)

FAB:	101809926(PDGFRB)

OMA:	130258544(PDGFRB)

PHI:	102111524(PDGFRB)

PMAJ:

107210844(PDGFRB)

CCAE:

111935543(PDGFRB)

CCW:	104689579(PDGFRB)

CBRC:

103611401(PDGFRB)

ACOE:

138117959(PDGFRB)

ETL:	114063193(PDGFRB)

ZAB:	102073695(PDGFRB)

ZLE:	135453548(PDGFRB)

ACHL:

103802359(PDGFRB)

SVG:	106859573(PDGFRB)

MMEA:

130579332(PDGFRB)

HRT:	120759145(PDGFRB)

SATI:

136367489(PDGFRB)

CFAI:

136297146(PDGFRB)

CCIC:

134049474(PDGFRB)

FPG:	101918438(PDGFRB)

FCH:	102052718(PDGFRB)

CCRI:

104163914(PDGFRB)

NNT:	104413057(PDGFRB)

SHAB:

115615917(PDGFRB)

ACUN:

113485173(PDGFRB)

SURA:

141949704(PDGFRB)

TALA:

104357574(PDGFRB)

ACHC:

115334242(PDGFRB)

HALD:

104324083(PDGFRB)

HLE:	104838898(PDGFRB)

AGEN:

126050952

HHAR:

128155105(PDGFRB)

BBUT:

142044134(PDGFRB)

GCL:

127021839

CSTI:

104563590(PDGFRB)

LDI:	104352678(PDGFRB)

MNB:	103776410(PDGFRB)

DPUB:

104309991(PDGFRB)

PPUS:

135185373(PDGFRB)

AVIT:

104276794(PDGFRB)

BRHI:

104490081(PDGFRB)

EGZ:	104123312(PDGFRB)

NNI:	104014196(PDGFRB)

PCRI:

104036032(PDGFRB)

PCAO:

104049359(PDGFRB)

PADL:

103915745(PDGFRB)

AFOR:

103904388(PDGFRB)

FGA:	104074292(PDGFRB)

CBOR:

142088896(PDGFRB)

GSTE:

104258673(PDGFRB)

CBOY:

140657122(PDGFRB)

MAME:

142413360(PDGFRB)

CLV:	102096790(PDGFRB)

CNIC:

135993774(PDGFRB)

MUI:	104541100(PDGFRB)

PGUU:

104463785(PDGFRB)

PLET:

104627578(PDGFRB)

EHS:	104517261(PDGFRB)

CMAC:

104479936(PDGFRB)

CUCA:

104059466(PDGFRB)

TEO:	104377141(PDGFRB)

BREG:

104637989(PDGFRB)

GAME:

129212774(PDGFRB)

OHA:	104326896(PDGFRB)

ACAR:

104523710(PDGFRB)

CPEA:

104392712(PDGFRB)

CVF:	104293116(PDGFRB)

RTD:	128916197(PDGFRB)

CRID:

134521859(PDGFRB)

LMIC:

141749805(PDGFRB)

NARQ:

141469757(PDGFRB)

AAM:	106493441(PDGFRB)

AROW:

112964785(PDGFRB)

NPD:	112954304(PDGFRB)

TGT:	104579953(PDGFRB)

DNE:	112996927(PDGFRB)

SCAM:

104142203(PDGFRB)

ASN:	102372962(PDGFRB)

AMJ:	102566175(PDGFRB)

CPOO:

109310161(PDGFRB)

GGN:	109289892(PDGFRB)

PSS:	102460895(PDGFRB)

CIZ:	142020996(PDGFRB)

CMY:	102944650(PDGFRB)

CCAY:

125640811(PDGFRB)

LKP:	140915562(PDGFRB)

NDS:	141991899(PDGFRB)

DCC:	119860427(PDGFRB)

CPIC:

101940553(PDGFRB)

CABI:

116819978(PDGFRB)

MRV:	120369946(PDGFRB)

ACS:	100555784(pdgfrb)

ASAO:

132768948(PDGFRB)

PVT:	110086089(PDGFRB)

SUND:

121923103(PDGFRB)

PBI:	103051588(PDGFRB)

PMUR:

107294993

CTIG:

120306869(PDGFRB)

TSR:	106547766(PDGFRB)

PGUT:

117655249(PDGFRB)

PCAE:

139309693(PDGFRB)

APRI:

131190103(PDGFRB)

PTEX:

113433810(PDGFRB)

NSS:	113424511(PDGFRB)

VKO:	123035769(PDGFRB)

PMUA:

114591343(PDGFRB)

PRAF:

128407955(PDGFRB)

ZVI:	118080419(PDGFRB)

HCG:	128348139(PDGFRB)

STOW:

125429083(PDGFRB)

EMC:	129327498(PDGFRB)

XLA:	108712643(pdgfrb.S)

XTR:	100487523(pdgfrb)

NPR:	108785807(PDGFRB)

RTEM:

120932546(PDGFRB)

ACAT:

141132533(PDGFRB)

PADS:

140323476(PDGFRB)

BBUF:

121008278(PDGFRB)

BGAR:

122928360(PDGFRB)

DTC:	141083634(PDGFRB)

PWL:	138245700(PDGFRB)

MUO:	115459682 115475707(PDGFRB)

GSH:	117351655(PDGFRB)

DRE:	559529(pdgfrb)

SRX:	107747104 107754478

SANH:

107690880 107693052

SGH:	107568132 107588322

CCAR:

109046273 109046274

CAUA:

113069557 113113654

CGIB:

127971200 128027781

PTET:

122357618(pdgfrb)

LROH:

127176102(pdgfrb)

GRF:	141287871(pdgfrb)

OMC:	131553121(pdgfrb)

PPRM:

120473205(pdgfrb)

RKG:	130086544(pdgfrb)

MAMB:

125275641(pdgfrb)

CIDE:

127494775

CERY:

137020759(pdgfrb)

MASI:

127413383 127418070

TROS:

130549417(pdgfrb)

TDW:	130437873(pdgfrb)

MANU:

129421970(pdgfrb)

PDAB:

135760105(pdgfrb)

IPU:

108274697

IFU:	128618503(pdgfrb)

PHYP:

113529620(pdgfrb)

SMEO:

124392347(pdgfrb)

TFD:	113654892(pdgfrb)

TVC:	132856700(pdgfrb)

CGAR:

128545729(pdgfrb)

NGRA:

132882023(pdgfrb)

TRN:	134307010(pdgfrb)

AMEX:

103036483(pdgfrb)

CMAO:

118811440(pdgfrb)

EEE:	113575581(pdgfrb)

CHAR:

105904594 116220866(pdgfrb)

SPIL:

134080394 134095417(pdgfrb)

ASAD:

121681269(pdgfrb) 121709602

TRU:	101061130 101074724(pdgfrb)

TFS:	130531302(pdgfrb) 130537161

TNG:	GSTEN00014570G001 GSTEN00026578G001

LCO:	104919444 104927056

NCC:	104965701(pdgfrb)

TBEN:

117470913(pdgfrb) 117490686

CGOB:

115014733(pdgfrb) 115019444

PGEO:

117453732(pdgfrb)

GACU:

117556048(pdgfrb)

EMAC:

134859941(pdgfrb) 134872060

ELY:	117260792(pdgfrb) 117270921

EFO:	125894963(pdgfrb) 125898196

PLEP:

121939111 121947843(pdgfrb)

SLUC:

116062368 116064307(pdgfrb)

ECRA:

117951210(pdgfrb)

ESP:	116696884(pdgfrb)

PFLV:

114562615(pdgfrb) 114566403

GAT:	120817382(pdgfrb)

PPUG:

119210567(pdgfrb)

AFB:	129090064(pdgfrb) 129113389

CLUM:

117737933(pdgfrb) 117742953

PSWI:

130209934(pdgfrb)

CANA:

137787481 137796412(pdgfrb)

CVE:	137871490 137875447(pdgfrb)

MSAM:

119888610(pdgfrb) 119895825 119918588

SCHU:

122880357(pdgfrb) 122888272

EARM:

139291521(pdgfrb) 139294990

CUD:	121516062(pdgfrb) 121519179

SPUL:

138598648(pdgfrb) 138601754

LMIX:

132981827(pdgfrb) 132988390

HTC:	141791488 141793314(pdgfrb)

ALAT:

119008149(pdgfrb) 119031152

ASTR:

137602890(pdgfrb) 137606311

PKLU:

139207289(pdgfrb) 139224737

MZE:	101466822 101484671(pdgfrb)

ONL:	100695603(pdgfrb) 100709470

OAU:	116329079(pdgfrb) 116329738

OLA:	101155039(pdgfrb) 101156428

OML:	112136844 112153320(pdgfrb)

CSAI:

133446945(pdgfrb) 133460013

XMA:	102229755 102233464(pdgfrb)

XCO:	114139478(pdgfrb) 114153115

XHE:	116713960(pdgfrb) 116728444

PRET:

103459902 103471279(pdgfrb)

PFOR:

103135514 103135517 103141073(pdgfrb)

PLAI:

106939821 106948556(pdgfrb)

PMEI:

106907217(pdgfrb) 106918551

GAF:	122837604(pdgfrb) 122844817

PPRL:

129362573(pdgfrb) 129370750

CVG:	107095000(pdgfrb) 107102292

CTUL:

119777911(pdgfrb) 119785587

GMU:	124860432(pdgfrb) 124876578

NFU:	107375657(pdgfrb)

KMR:	108228837 108240544(pdgfrb)

ALIM:

106517359(pdgfrb) 106532997

NWH:	119408779(pdgfrb)

AOCE:

111569523(pdgfrb) 111575719 129350537

EJA:	138211110(pdgfrb) 138213625

BFRE:

138631547 138633639(pdgfrb)

MCEP:

125008222(pdgfrb) 125021590

CSEM:

103391002(pdgfrb) 103392104

POV:	109626437(pdgfrb)

SSEN:

122762812 122778422(pdgfrb)

SSOE:

131471785 131472429(pdgfrb)

HHIP:

117769118(pdgfrb)

HSP:	118112689(pdgfrb) 118122120

PPLT:

128445395(pdgfrb)

SMAU:

118300833 118319653(pdgfrb)

LCF:	108873646 108899186

SDU:	111226471(pdgfrb) 111239485

SLAL:

111646633(pdgfrb) 111671142

XGL:	120785203(pdgfrb) 120802843

HCQ:	109518748(pdgfrb) 109528881

SSCV:

125981963 125983071(pdgfrb)

SBIA:

133491365 133509123(pdgfrb)

PEE:	133407552(pdgfrb) 133415885

PTAO:

133467039 133484435(pdgfrb)

BPEC:

110157622 110174958

ENY:	140354475(pdgfrb) 140355543

MALB:

109955104 109973182

BSPL:

114864577(pdgfrb) 114869682

SJO:	128363114(pdgfrb) 128371860

SSCO:

133986117(pdgfrb) 133993700

TTY:	137189324(pdgfrb) 137196227

GMH:

115547975

SASA:

100380851(pgfrb) 106604848 106611876

STRU:

115154887 115174164 115205391

OTW:	112220770 112229041 112256098

OMY:	110488623 110504831 110534178

OGO:	123993263 124005726 124011140

ONE:	115129341 115130536 115135457

OKI:	109864648 109873120 109905074

OKE:	118376080(pdgfrb) 118383741 118390546

OMM:	135526234 135545741 135550247

OCLA:

139366170 139390622 139418694

SALP:

111950745 111965401 111967388

SNH:	120048189 120057342 120062390

SFON:

129827801 129857924 129868660

CCLU:

121541959 121544573 121579656 121579850

ELS:	105025839 105030015

OEP:	134013877 134032361(pdgfrb)

SFM:	108936824(pdgfrb)

PKI:	111855164(pdgfrb)

AANG:

118223372(pdgfrb) 118234934

AROT:

135249857(pdgfrb) 135263605

CCOG:

133125298(pdgfrb) 133132943

LOC:	102697036(pdgfrb)

PSPA:

121297330(pdgfrb) 121324756

ARUT:

117413283(pdgfrb)

PSEX:

120542138(pdgfrb)

LCM:	102361386(PDGFRB)

CMK:

103188232

CPLA:

122556457(pdgfrb)

CPUN:

140491889(pdgfrb)

HOC:	132823488(pdgfrb)

SCAU:

119965441

LERI:

129701573(pdgfrb)

HAKA:

140739118(pdgfrb)

NLO:	107218496 107218532

NVG:

124307265

ATEN:

116297063

AQU:	100631815 109593746

» show all

Reference

PMID:15583853

Authors

Jones AV, Cross NC

Title

Oncogenic derivatives of platelet-derived growth factor receptors.

Journal

Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z

Reference

PMID:2835772

Authors

Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ

Title

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

Journal

Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435

Sequence

[hsa:5159]

LinkDB

ORTHOLOGY: K05099

Entry

K05099                      KO

Symbol

MET, HGFR

Name

proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04360

Axon guidance

map04361

Axon regeneration

map04510

Focal adhesion

map04520

Adherens junction

map05100

Bacterial invasion of epithelial cells

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05144

Malaria

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05211

Renal cell carcinoma

map05218

Melanoma

map05223

Non-small cell lung cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05230

Central carbon metabolism in cancer

Disease

H00014

Non-small cell lung cancer

H00018

Gastric cancer

H00021

Renal cell carcinoma

H00046

Cholangiocarcinoma

H00048

Hepatocellular carcinoma

H00605

Deafness, autosomal recessive

H00811

Distal arthrogryposis

H01985

Desmoplastic small round cell tumor

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04014 Ras signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04015 Rap1 signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04020 Calcium signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04151 PI3K-Akt signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04520 Adherens junction
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04361 Axon regeneration
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05202 Transcriptional misregulation in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05206 MicroRNAs in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05205 Proteoglycans in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05208 Chemical carcinogenesis - reactive oxygen species
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05230 Central carbon metabolism in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05226 Gastric cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05218 Melanoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05211 Renal cell carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05223 Non-small cell lung cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05100 Bacterial invasion of epithelial cells
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09174 Infectious disease: parasitic
   05144 Malaria
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  MET family
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met

Genes

HSA:

4233(MET)

PTR:	463671(MET)

PPS:	100991777(MET)

GGO:	101127399(MET)

PON:	100137030(MET)

PPYG:

129040721(MET)

NLE:	100597172(MET)

HMH:	116814273(MET)

SSYN:

129484916(MET)

MCC:	704562(MET)

MCF:	102123512(MET)

MTHB:

126951204

MNI:	105475620(MET)

CSAB:

103226771(MET)

CATY:

105598476(MET)

PANU:

100126669(MET)

TGE:	112620574(MET)

MLEU:

105553697(MET)

RRO:	104682633(MET)

RBB:	108528695(MET)

TFN:	117073436(MET)

PTEH:

111553422(MET)

CANG:

105508514(MET)

CJC:	100408551(MET)

SBQ:	101038696(MET)

CIMI:

108308984(MET)

ANAN:

105720430(MET)

CSYR:

103268739(MET)

MMUR:

105869368(MET)

LCAT:

123646854(MET)

ERUF:

138377591(MET)

PCOQ:

105817148(MET)

OGA:	100948196(MET)

MMU:	17295(Met)

MCAL:

110295947(Met)

MPAH:

110316104(Met)

RNO:	24553(Met)

MCOC:

116098601(Met)

ANU:	117720551(Met)

ASYL:

127678373(Met)

MUN:	110558703(Met)

CGE:	100751933(Met)

MAUA:

101825509(Met)

PROB:

127215335(Met)

PLEU:

114694721(Met)

PMAV:

102921464(Met)

MORG:

121463319(Met)

MFOT:

126503908

AAMP:

119806540(Met)

CNL:	130873377(Met)

NGI:	103737431(Met)

HGL:	101725772(Met)

CPOC:

100718790(Met)

CCAN:

109689877(Met)

DORD:

105988408(Met)

DSP:	122121823(Met)

DMER:

138809734(Met)

PLOP:

125347055(Met)

NCAR:

124990426

MMMA:

107144489(Met)

ITI:	101973838(Met)

OCU:	100126565(MET)

OPI:	101535058(MET)

OCZ:	121170862(MET)

TUP:	102485847(MET)

GVR:	103597189(MET)

CFA:	403438(MET)

CLUD:

112670796(MET)

VVP:	112929871(MET)

VLG:	121474658(MET)

NPO:	129502777(MET)

AML:	100480742(MET)

UMR:	103676585(MET)

UAH:	113263211(MET)

UAR:	123789034(MET)

ELK:

111151956

LLV:

125080939

MPUF:

101675655(MET)

MNP:	132015770(MET)

MLK:	131829655(MET)

NVS:	122905007(MET)

ORO:	101365730(MET)

EJU:	114210625(MET)

ZCA:	113911366(MET)

MLX:	118021010(MET)

NSU:	110588887(MET)

LWW:	102735430(MET)

FCA:	493669(MET)

PYU:	121028446(MET)

PCOO:

112866634(MET)

PBG:	122488133(MET)

PVIV:

125160764(MET)

LRUF:

124524670

LGF:	123606743(MET)

AJU:

106970667

PTG:	102953616(MET)

PPAD:

109248389(MET)

PUC:

125930874

PLEZ:

122210195(MET)

HHV:	120223826(MET)

BTA:	280855(MET)

BOM:	102285634(MET)

BIU:	109557411(MET)

BBUB:

102393442(MET)

BKE:	129659167(MET)

BBIS:

104981942(MET)

CHX:	102181186(MET)

OAS:	443076(MET)

BTAX:

128046469(MET)

CSUM:

138079844(MET)

ODA:	120878210(MET)

CCAD:

122438342(MET)

MREE:

136171193(MET)

OVR:	110125439(MET)

MBEZ:

129552423(MET)

SSC:	654328(MET)

CFR:

102504138

CBAI:

105063149(MET)

CDK:

105085321

VPC:	102538354(MET)

BACU:

103002086(MET)

BMUS:

118900502(MET)

LVE:	103090984(MET)

OOR:	101280136(MET)

LALB:

132524620(MET)

GMF:	115853870(MET)

DDP:	132431157(MET)

DLE:	111179292(MET)

PCAD:

102987522(MET)

PSIU:

116759279(MET)

PPHC:

136128057(MET)

NASI:

112408223(MET)

ECB:	100056013(MET)

EPZ:	103562070(MET)

EAI:	106829287(MET)

MYB:	102263347(MET)

MYD:

102753524

MMYO:

118666481(MET)

MLF:	102441042(MET)

MDT:	132242672(MET)

MYUM:

139016126(MET)

PKL:	118711705(MET)

EFUS:

103295948(MET)

MNA:	107528536(MET)

DRO:	112300421(MET)

AJM:	119038260(MET)

PDIC:

114507559(MET)

PHAS:

123824375(MET)

MMF:	118619859(MET)

PPAM:

129063382(MET)

HAI:	109389346(MET)

RFQ:	117018153(MET)

PALE:

102885990(MET)

PGIG:

120601224(MET)

PVP:	105300269(MET)

RAY:	107497465(MET)

MJV:	108399322(MET)

TOD:	119245963(MET)

SARA:

101552331(MET)

SFUM:

130027492(MET)

SETR:

126004843(MET)

LAV:	100656285(MET)

TMU:

101345595

ETF:	101651069(MET)

DNM:	101437323(MET)

MDO:	100013788(MET)

GAS:	123250354(MET)

SHR:	100917007(MET)

AFZ:

127538921

PCW:	110202946(MET)

TVP:	118850072(MET)

PBRV:

138176289(MET)

MLAO:

141493028(MET)

OAA:	100079345(MET)

TACU:

119933077(MET)

GGA:	396134(MET)

PCOC:

116243979(MET)

MGP:	100544894(MET)

CJO:	107309125(MET)

TPAI:

128073475(MET)

LMUT:

125694049(MET)

NMEL:

110392601(MET)

APLA:

101801559(MET)

AACU:

137849676(MET)

ACYG:

106042077(MET)

CATA:

118246692(MET)

AFUL:

116486260(MET)

TGU:	100227998(MET)

LSR:	110477141(MET)

SCAN:

103813465(MET)

PMOA:

120510753(MET)

OTC:	121344817(MET)

PRUF:

121355793(MET)

ATRC:

139588392(MET)

GFR:	102035281(MET)

FAB:	101822032(MET)

OMA:	130266136(MET)

PHI:	102099870(MET)

PMAJ:

107204940(MET)

CCAE:

111931552(MET) 111943846

CCW:	104698290(MET)

CBRC:

103614760(MET)

ACOE:

138099639(MET)

ETL:	114062356(MET)

ZAB:	102070163(MET)

ZLE:	135442645(MET)

ACHL:

103812167(MET)

SVG:	106862903(MET)

MMEA:

130589230(MET)

HRT:	120752306(MET)

SATI:

136361227(MET)

CFAI:

136289341(MET)

CCIC:

134043060(MET)

FPG:	101921590(MET)

FCH:	102046148(MET)

CCRI:

104159448(MET)

NNT:	104410927(MET)

SHAB:

115604873(MET)

ACUN:

113491414(MET)

SURA:

141944113(MET)

TALA:

104365761(MET)

ACHC:

115341817(MET)

HALD:

104317358(MET)

HLE:	104835818(MET)

AGEN:

126044569

HHAR:

128143159(MET)

BBUT:

142045534(MET)

GCL:

127015665

CSTI:

104549286

LDI:	104354895(MET)

MNB:	103770113(MET)

DPUB:

104309184(MET)

PPUS:

135174676(MET)

AVIT:

104271276(MET)

BRHI:

104492045(MET)

EGZ:	104133409(MET)

NNI:	104013588(MET)

PCRI:

104036015(MET)

PCAO:

104045449(MET)

PADL:

103916977(MET)

AFOR:

103905227(MET)

FGA:	104083304(MET)

CBOR:

142080974(MET)

GSTE:

104261715(MET)

CBOY:

140651683(MET)

MAME:

142405706(MET)

CLV:	102091194(MET)

CNIC:

135987092(MET)

MUI:	104541996(MET)

PGUU:

104462723(MET)

PLET:

104628579(MET)

EHS:	104502781(MET)

CMAC:

104479811(MET)

CUCA:

104064326(MET)

TEO:	104373369(MET)

BREG:

104634540(MET)

GAME:

129203945(MET)

OHA:	104337524(MET)

ACAR:

104528108(MET)

CPEA:

104394665(MET)

CVF:	104288299(MET)

RTD:	128911820(MET)

CRID:

134510212(MET)

LMIC:

141749350(MET)

NARQ:

141478945(MET)

AAM:	106488808(MET)

AROW:

112965492(MET)

NPD:	112942328(MET)

TGT:	104573695(MET)

DNE:	112981591(MET)

SCAM:

104153533(MET)

ASN:	102387009(MET)

AMJ:	102568767(MET)

CPOO:

109315620(MET)

GGN:	109295605(MET)

PSS:	102447079(MET)

CIZ:	142023663(MET)

CMY:	102936928(MET)

CCAY:

125630351(MET)

LKP:	140905240(MET)

NDS:	141980740(MET)

DCC:	119848506(MET)

CPIC:

101931256(MET)

TST:	117876645(MET)

CABI:

116830742

MRV:	120387625(MET)

ACS:	100561443(met)

ASAO:

132776257(MET)

PVT:	110077032(MET)

SUND:

121930972(MET)

PBI:	103067929(MET)

PMUR:

107285371(MET)

CTIG:

120305326(MET)

TSR:	106557423(MET)

PGUT:

117673589(MET)

PCAE:

139319020(MET)

APRI:

131202211(MET)

PTEX:

113444350(MET)

NSS:	113413069(MET)

VKO:	123019909(MET)

PMUA:

114605269(MET)

PRAF:

128422199(MET)

ZVI:	118090716(MET)

HCG:	128326781(MET)

GJA:	107114504(MET)

STOW:

125434856(MET)

EMC:	129335861(MET)

XLA:	108712362(met.S) 373551(met.L)

XTR:	100485823(met)

NPR:	108788984(MET)

RTEM:

120931873(MET)

ACAT:

141131968(MET)

PADS:

140324015(MET)

BBUF:

120981713(MET)

BGAR:

122927947(MET)

DTC:	141087664(MET)

PWL:	138287911(MET)

MUO:	115478704(MET)

GSH:	117367214(MET)

DRE:	100150664(met)

SRX:

107716667

SANH:

107665714 107679602

SGH:	107574004 107574814

CCAR:

109065147

CAUA:

113043267 113066757

CGIB:

127947065 128014220

PTET:

122330906(met)

LROH:

127157122(met)

GRF:	141301311(met)

OMC:	131533942(met)

PPRM:

120458971(met)

RKG:	130085331(met)

MAMB:

125246846(met)

CIDE:

127506703

CERY:

137015501(met)

MASI:

127436260 127437518

TROS:

130551690(met)

TDW:	130414577(met)

MANU:

129433139(met)

PDAB:

135781370(met)

IPU:

108268944

IFU:	128611764(met)

PHYP:

113546663(met)

SMEO:

124386026(met)

TFD:	113651488(met)

TVC:	132855469(met)

CGAR:

128532075(met)

NGRA:

132890988(met)

TRN:	134319520(met)

AMEX:

103023930(met)

CMAO:

118806734(met)

EEE:	113581523(met) 113584980

CHAR:

105895653(met)

SPIL:

134093525(met)

ASAD:

121723226(met)

TRU:	100137507(met)

TFS:	130536314(met)

TNG:	GSTEN00029819G001

LCO:	104931751(met)

TBEN:

117497226(met)

CGOB:

115010196(met)

GACU:

117538696(met)

EMAC:

134883948(met)

ELY:	117262484(met)

EFO:	125886736(met)

PLEP:

121950165(met)

SLUC:

116036253(met)

ECRA:

117949070(met)

ESP:	116693711(met)

PFLV:

114560667(met)

GAT:	120809534(met)

PPUG:

119196051(met)

AFB:	129108330(met)

CLUM:

117732749(met)

PSWI:

130194916(met)

CANA:

137804081(met)

CVE:	137868031(met)

MSAM:

119894195(met)

SCHU:

122874651(met)

EARM:

139286518(met)

CUD:	121515323(met)

SPUL:

138612657(met)

LMIX:

132972852(met)

HTC:	141796696(met)

ALAT:

119024820(met)

ASTR:

137593852(met)

PKLU:

139200990(met)

MZE:	101465566(met)

ONL:	100709985(met)

OAU:	116317475(met)

OLA:	101174570(met)

OML:	112139178(met)

CSAI:

133443732(met)

XMA:	102219516(met)

XCO:	114142761(met)

XHE:	116709506(met)

PRET:

103465633(met)

PFOR:

103150629

PLAI:

106953500(met)

PMEI:

106930677(met)

GAF:	122836079(met)

PPRL:

129353366(met)

CVG:	107083224(met)

CTUL:

119780439(met)

GMU:	124858154(met)

NFU:	107388350(met)

KMR:	108248206(met)

ALIM:

106511318 106518848(met)

NWH:	119415889(met)

AOCE:

111572785(met)

EJA:	138206339(met)

BFRE:

138614780

MCEP:

125014929(met)

CSEM:

103379587(met)

POV:	109624638(met)

SSEN:

122776525(met)

SSOE:

131470241(met)

HHIP:

117763003(met)

HSP:	118109571(met)

PPLT:

128444037(met)

SMAU:

118315563(met)

LCF:

108893984

SDU:	111220524(met)

SLAL:

111672169(met)

XGL:	120793161(met)

HCQ:	109530899(met)

SSCV:

125970849(met)

SBIA:

133502047(met)

PEE:	133403286(met)

PTAO:

133478154(met)

BPEC:

110155115(met)

ENY:	140349302(met)

MALB:

109956390(met)

BSPL:

114857516(met)

SJO:	128358566(met)

SSCO:

133982424(met)

TTY:	137183509(met)

GMH:	115550657(met)

SASA:

106561553 106573120

STRU:

115152322 115197549

OTW:	112219023(met) 112252650

OMY:	110502318(met) 110532382

OGO:	124003963 124033603

ONE:	115109662 115134836

OKI:	109867023 109888715

OKE:	118370727(met) 118400969

OMM:	135509047(met) 135524119

OCLA:

139375219 139408271

SALP:

111952422 111961046

SNH:	120041135 120054155(met)

SFON:

129862095 129866590

CCLU:

121531537 121531679(met)

ELS:	105029522(met)

OEP:	134020942(met)

SFM:	108918795 108931650

PKI:	111836018 111842454(met)

AANG:

118219163 118231561(met)

AROT:

135246050 135259110(met)

CCOG:

133119378 133135597(met)

LOC:	102696260(met)

PSPA:

121318228 121319884

ARUT:

117415916 117420109

PSEX:

120534110(met)

LCM:	102366006(MET)

CMK:	103179355(met)

RTP:	109911784(met)

CPLA:

122559685(met)

CPUN:

140457833(met)

HOC:	132824922(met)

SCAU:

119955000(met)

LERI:

129706038(met)

HAKA:

140734872(met)

PMRN:

116947434 116952409(MST1R)

LRJ:	133351732 133355399

BFO:	118411354 118412574 118415187

BBEL:

109473409 109475017 109480177 109485312

CIN:

SCLV:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

140147204 140148030 140149172

PFLL:

139134593 139135408

DSV:	119461277 119462194

DALB:

135899166 135899217 135920212

RSAN:

119396274 119397247 119397461

RMP:	119173844 119174509

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_T14E8.1(svh-2)

CBR:

CBG_10839

CRQ:	GCK72_024607

BMY:	BM_BM5789(Bma-svh-2)

LOA:	LOAG_02533

LGI:	LOTGIDRAFT_167952 LOTGIDRAFT_167954 LOTGIDRAFT_168736

PVUL:

126826695 126826696 126827069 126827949 130010552

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:	124121093 124136756 124141250

HRJ:	124258576 124258685 124267286

HASI:

137296186

HCRA:

139445905 139446504

CRG:	105317736 105317737 105342559

CANU:

128158412 128160296 128160458

CVN:	111106539 111108496 111109831 111110043 111110330

OED:	125653452 125654125

MYI:	110462240 110462241 110462242

PMAX:

117330473 117330474 117331752

AIRR:

138304900 138336155 138336636

YBA:	132558587 132558623 132558634

MMER:

123528620 123528621 123529552 123530483

RPHI:

132732697 132737974 132742768 132744705

DPOL:

127881492 127881602 127881605 127882123

MAEA:

128217379 128217784 128218301 128218303 128218304

OBI:

106879211

OSN:

115222585

LJP:

135472806

LAK:	106151934 106155548 106160204 106160970 106175580

LLON:

135502861

» show all

Reference

PMID:2819873

Authors

Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude G

Title

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

Journal

Proc Natl Acad Sci U S A 84:6379-83 (1987)
DOI:10.1073/pnas.84.18.6379

Sequence

[hsa:4233]

LinkDB

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