KEGG   ORTHOLOGY: K04361
Entry
K04361                      KO                                     
Symbol
EGFR, ERBB1
Name
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04072  Phospholipase D signaling pathway
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04214  Apoptosis - fly
map04320  Dorso-ventral axis formation
map04510  Focal adhesion
map04520  Adherens junction
map04540  Gap junction
map04630  JAK-STAT signaling pathway
map04810  Regulation of actin cytoskeleton
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05131  Shigellosis
map05160  Hepatitis C
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05219  Bladder cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
H02467  Neonatal inflammatory skin and bowel disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 JAK-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04928 Parathyroid hormone synthesis, secretion and action
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05207 Chemical carcinogenesis - receptor activation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05208 Chemical carcinogenesis - reactive oxygen species
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05226 Gastric cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05171 Coronavirus disease - COVID-19
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05163 Human cytomegalovirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05131 Shigellosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Other DBs
GO: 0005006
Genes
HSA: 1956(EGFR)
PTR: 463415(EGFR)
PPS: 100974885(EGFR)
GGO: 101126190(EGFR)
PON: 100459280(EGFR)
NLE: 100597255(EGFR)
MCC: 613027(EGFR)
MCF: 102138724(EGFR)
CSAB: 103226055(EGFR)
CATY: 105588269(EGFR)
PANU: 101003588(EGFR)
TGE: 112620091(EGFR)
RRO: 104675886(EGFR)
RBB: 108522039(EGFR)
TFN: 117073506(EGFR)
PTEH: 111555709(EGFR)
CJC: 100412158(EGFR)
SBQ: 101047461(EGFR)
CSYR: 103268107(EGFR)
MMUR: 105877217(EGFR)
OGA: 100950302(EGFR)
MMU: 13649(Egfr)
MCAL: 110304228(Egfr)
MPAH: 110330480(Egfr)
RNO: 24329(Egfr)
MCOC: 116071392(Egfr)
CGE: 100774580(Egfr)
PLEU: 114705532(Egfr)
NGI: 103748852
HGL: 101723771(Egfr)
CPOC: 100725363(Egfr)
CCAN: 109693753(Egfr)
DORD: 106000675(Egfr)
DSP: 122112209(Egfr)
OCU: 100008806(EGFR)
TUP: 102485304(EGFR)
CFA: 404306(EGFR)
VVP: 112925820(EGFR)
VLG: 121471236(EGFR)
UMR: 103674660(EGFR)
UAH: 113257444(EGFR)
UAR: 123786270(EGFR)
ELK: 111157042
LLV: 125080419
MPUF: 101685824(EGFR)
ORO: 101386858(EGFR)
EJU: 114213645(EGFR)
ZCA: 113911010(EGFR)
MLX: 118024535(EGFR)
FCA: 100510799(EGFR)
PYU: 121017018(EGFR)
PBG: 122487677(EGFR)
PTG: 102967370(EGFR)
PPAD: 109267979(EGFR)
AJU: 106976977(EGFR)
HHV: 120238884(EGFR)
BTA: 407217(EGFR)
BOM: 102269868
BIU: 109576048(EGFR)
BBUB: 102398103(EGFR)
CHX: 102172767(EGFR)
OAS: 780479(EGFR)
ODA: 120867903(EGFR)
CCAD: 122424243(EGFR)
SSC: 397070(EGFR)
CFR: 102504272(EGFR)
CBAI: 105067674(EGFR)
CDK: 105105749(EGFR)
VPC: 102538051(EGFR)
BACU: 103017029(EGFR)
LVE: 103071962(EGFR)
OOR: 101275398(EGFR)
DLE: 111184548(EGFR)
PCAD: 102975467(EGFR)
PSIU: 116759758(EGFR)
ECB: 100067755(EGFR)
EPZ: 103560128(EGFR)
EAI: 106824133(EGFR)
MYB: 102257758(EGFR)
MYD: 102775204(EGFR)
MMYO: 118665909(EGFR)
MLF: 102435209(EGFR)
MNA: 107525996(EGFR)
PKL: 118727800(EGFR)
HAI: 109388365(EGFR)
DRO: 112306912(EGFR)
SHON: 118983507(EGFR)
AJM: 119057339(EGFR)
PDIC: 114507607(EGFR)
PHAS: 123811124(EGFR)
MMF: 118620077(EGFR)
RFQ: 117012187(EGFR)
PALE: 102893495(EGFR)
PGIG: 120602477(EGFR)
PVP: 105306141
RAY: 107498193(EGFR)
MJV: 108406292
TOD: 119231744(EGFR)
SARA: 101552863(EGFR)
LAV: 100659125(EGFR)
TMU: 101356822
DNM: 105746538(EGFR)
MDO: 100029625(EGFR)
GAS: 123247456(EGFR)
SHR: 100914017(EGFR)
PCW: 110204990(EGFR)
OAA: 100075894(EGFR)
GGA: 396494(EGFR)
PCOC: 116232773(EGFR)
MGP: 100543252(EGFR)
CJO: 107309802(EGFR)
NMEL: 110393050(EGFR)
APLA: 101797830(EGFR)
ACYG: 106046417(EGFR)
AFUL: 116485864(EGFR)
TGU: 100221035(EGFR)
LSR: 110471171(EGFR)
SCAN: 103819418(EGFR)
PMOA: 120505010(EGFR)
OTC: 121346981(EGFR)
PRUF: 121352949(EGFR)
GFR: 102045482(EGFR)
FAB: 101818290(EGFR)
PHI: 102101445(EGFR)
PMAJ: 107200328(EGFR)
CCAE: 111923657(EGFR)
CCW: 104689262(EGFR)
ETL: 114057239(EGFR)
ZAB: 102066957(EGFR)
FPG: 101910521(EGFR)
FCH: 102058683(EGFR)
CLV: 102097879(EGFR)
EGZ: 104131586(EGFR)
NNI: 104012443(EGFR)
ACUN: 113477535(EGFR)
TALA: 104366457(EGFR)
PADL: 103914859(EGFR)
ACHC: 115338920(EGFR)
AAM: 106495273(EGFR)
AROW: 112970678(EGFR)
NPD: 112945566(EGFR)
DNE: 112996092(EGFR)
ASN: 102378285(EGFR)
AMJ: 102565209(EGFR)
CPOO: 109312928(EGFR)
GGN: 109291886(EGFR)
PSS: 102443405(EGFR)
CMY: 102933326(EGFR)
CPIC: 101952725(EGFR)
TST: 117872619(EGFR)
CABI: 116832636(EGFR)
MRV: 120397061(EGFR)
ACS: 100562231(egfr)
PVT: 110081594(EGFR)
SUND: 121935547(EGFR)
PBI: 103050691(EGFR)
PMUR: 107284695(EGFR)
TSR: 106539158(EGFR)
PGUT: 117664986(EGFR)
VKO: 123023248(EGFR)
PMUA: 114607096(EGFR)
ZVI: 118077665(EGFR)
GJA: 107119225(EGFR)
XLA: 108719997(egfr.S) 724072(egfr.L)
XTR: 100492965(egfr)
RTEM: 120940364(EGFR)
BBUF: 121002062(EGFR)
BGAR: 122939241(EGFR)
DRE: 378478(egfra) 571431
IPU: 108280575(egfra)
PHYP: 113546391(egfr)
SMEO: 124403152(egfra)
EEE: 113587946 113590490(egfr)
TRU: 101069322(egfr) 101073748
CGOB: 115022485
ELY: 117264749 117272055(egfra)
PLEP: 121951033(egfra)
SLUC: 116046206(egfra) 116056499
ECRA: 117954310(egfra)
PFLV: 114548913 114564973(egfr)
GAT: 120811612 120816150(egfra)
PPUG: 119198448 119204022(egfra)
MSAM: 119901961(egfra) 119913984
CUD: 121519822(egfra)
OLA: 101159776(egfr) 101169984
OML: 112147305(egfra) 112151354
XCO: 114136421 114146596(egfr)
XHE: 116712093 116721778(egfr)
PRET: 103456976 103479868(egfr)
PFOR: 103135727(egfr) 103156750
PLAI: 106934486 106948569(egfr)
PMEI: 106903456 106924542(egfr)
GAF: 122824379 122841048(egfra)
CVG: 107081719(egfr) 107098892
CTUL: 119787990 119794178(egfra)
GMU: 124858134 124869445(egfra)
NFU: 107383161 107383833(egfr)
KMR: 108241698(egfra) 108250946
ALIM: 106531647 106533007(egfr)
NWH: 119415174(egfra)
AOCE: 111573600(egfr) 111586710
CSEM: 103377298 103396351(egfr)
SSEN: 122769592 122770192(egfra)
HHIP: 117753648 117777712(egfra)
LCF: 108883329(egfr) 108894667
SDU: 111231258(egfr) 111237405
SLAL: 111647380 111652941(egfr)
XGL: 120789875 120798813(egfra)
HCQ: 109521299(egfr) 109530291
BPEC: 110170351(egfr)
SFM: 108937670(egfr)
AANG: 118225251 118234624(egfra)
LOC: 102688253(egfr)
ARUT: 117400452(egfra)
CMK: 103181270(egfra)
RTP: 109927384
BBEL: 109465242
SPU: 586488
SKO: 100372961
DME: Dmel_CG10079(Egfr)
DER: 6548211
DSE: 6615396
DSI: Dsimw501_GD11601(Dsim_GD11601)
DAN: 6495667
DSR: 110189726
DPE: 6592980
DWI: 6637989
DGR: 6560193
DAZ: 108615522
DNV: 108653770
DHE: 111592533
DVI: 6627038
CCAT: 101448716
BOD: 106627005
MDE: 101887261
SCAC: 106096102
LCQ: 111687210
AGA: AgaP_AGAP008819(EGFR)
ACOZ: 120959256
AARA: 120900188
AAG: 5564544
CPII: 120426263
CNS: 116340995
AME: 100577393
ACER: 107993429
ALAB: 122721144
BIM: 100740344
BBIF: 117214759
BVK: 117233351
BVAN: 117157905
BTER: 100645521
BPYO: 122568480
CCAL: 108632582
OBB: 114874001
MGEN: 117222212
NMEA: 116429624
CGIG: 122399503
MPHA: 105828088
AEC: 105144059
ACEP: 105627284
PBAR: 105427056
VEM: 105567241
HST: 105191569
DQU: 106742590
CFO: 105257833
FEX: 115245656
LHU: 105676042
PGC: 109852274
OBO: 105287957
PCF: 106793740
PFUC: 122521157
VPS: 122629427
NVI: 100118970
CSOL: 105367460
TPRE: 106648579
MDL: 103576901
CGLO: 123259894
FAS: 105263900
DAM: 107042890
AGIF: 122860326
CCIN: 107273232
TCA: 660037(DER)
DPA: 109536124
SOY: 115880442
ATD: 109595878
CSET: 123318168
AGB: 108907320
LDC: 111509620
NVL: 108556379
PPYR: 116173497
OTU: 111421879
BMOR: 101741679
BMAN: 114245679
MSEX: 115455774
BANY: 112045731
PMAC: 106717252
PPOT: 106104475
PXU: 106126270
PRAP: 110998172
ZCE: 119835646
HAW: 110375773
TNL: 113507132
OFU: 114362521
PXY: 105385471
API: 100168353
DNX: 107162454
AGS: 114127776
RMD: 113550916
BTAB: 109031082
DCI: 103506274
CLEC: 106668239
HHAL: 106685904
NLU: 111048742
FOC: 113209899
ZNE: 110832144
FCD: 110842323
DMK: 116929417
HAME: 121865936
PCLA: 123756738
PTRU: 123509689
HAZT: 108676933
EAF: 111709702
DSV: 119442537
RSAN: 119387318
RMP: 119159406
VDE: 111252123
VJA: 111269280
TUT: 107359081
DPTE: 113792070
DFR: 124495381
CSCU: 111623507
CEL: CELE_ZK1067.1(let-23)
CBR: CBG_00911(Cbr-let-23)
BMY: BM_BM7615(Bma-let-23)
PCAN: 112561120
BGT: 106066507
GAE: 121387807
HRF: 124149536
HRJ: 124258906
CRG: 105330118(Egfr) 105330801
MYI: 110442986
PMAX: 117318155
LAK: 106153603
AQU: 100637905
 » show all
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
DOI:10.1038/309418a0
  Sequence
[hsa:1956]
LinkDB

KEGG   ORTHOLOGY: K05083
Entry
K05083                      KO                                     
Symbol
ERBB2, HER2, CD340
Name
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04020  Calcium signaling pathway
map04066  HIF-1 signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map04520  Adherens junction
map04530  Tight junction
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05219  Bladder cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00019  Pancreatic cancer
H00022  Bladder cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00046  Cholangiocarcinoma
H01508  Salivary gland cancer
H01554  Fallopian tube cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04012 ErbB signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04066 HIF-1 signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04020 Calcium signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04151 PI3K-Akt signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04520 Adherens junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04530 Tight junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05206 MicroRNAs in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05205 Proteoglycans in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05230 Central carbon metabolism in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05226 Gastric cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05219 Bladder cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05215 Prostate cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05213 Endometrial cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05224 Breast cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05223 Non-small cell lung cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01524 Platinum drug resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01522 Endocrine resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04090 CD molecules
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
CD molecules [BR:ko04090]
 Proteins
  K05083  CD340, ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
Genes
HSA: 2064(ERBB2)
PTR: 454636(ERBB2)
PPS: 100977227(ERBB2)
GGO: 101140885(ERBB2)
PON: 100450307(ERBB2)
NLE: 100601700(ERBB2)
MCC: 697573(ERBB2)
MCF: 102146608(ERBB2)
CSAB: 103243533(ERBB2)
CATY: 105579553(ERBB2)
PANU: 101007278(ERBB2)
TGE: 112608971(ERBB2)
RRO: 104674848(ERBB2)
RBB: 108527784(ERBB2)
TFN: 117067088(ERBB2)
PTEH: 111537465(ERBB2)
CJC: 100391332(ERBB2)
SBQ: 101043415(ERBB2)
CSYR: 103251030(ERBB2)
MMUR: 105872099(ERBB2)
OGA: 100953964(ERBB2)
MMU: 13866(Erbb2)
MCAL: 110304771(Erbb2)
MPAH: 110331339(Erbb2)
RNO: 24337(Erbb2)
MCOC: 116077605(Erbb2)
MUN: 110562952(Erbb2)
CGE: 100759983(Erbb2)
PLEU: 114706940(Erbb2)
NGI: 103743825(Erbb2)
HGL: 101705227(Erbb2)
CPOC: 100727657(Erbb2)
CCAN: 109693877(Erbb2)
DORD: 106003227(Erbb2)
DSP: 122103204(Erbb2)
OCU: 100009554(ERBB2)
OPI: 101527578(ERBB2)
TUP: 102487164(ERBB2)
CFA: 403883(ERBB2)
VVP: 112917778(ERBB2)
VLG: 121473120(ERBB2)
AML: 100480029(ERBB2)
UMR: 103661560(ERBB2)
UAH: 113265512(ERBB2)
UAR: 123779529(ERBB2)
ELK: 111151268
LLV: 125087205
MPUF: 101693248(ERBB2)
ORO: 101364161(ERBB2)
EJU: 114198487(ERBB2)
ZCA: 113939823(ERBB2)
MLX: 118024846(ERBB2)
FCA: 751824(ERBB2)
PYU: 121044914(ERBB2)
PBG: 122485481(ERBB2)
PTG: 102961961(ERBB2)
PPAD: 109247423(ERBB2)
AJU: 106980462(ERBB2)
HHV: 120229105(ERBB2)
BTA: 505709(ERBB2)
BOM: 102267975(ERBB2)
BIU: 109573971(ERBB2)
BBUB: 102398312(ERBB2)
CHX: 102181989(ERBB2)
OAS: 780519(ERBB2)
ODA: 120867212(ERBB2)
SSC: 100516641(ERBB2)
CFR: 102519604(ERBB2)
CBAI: 105073259(ERBB2)
CDK: 105099069(ERBB2)
VPC: 102539783(ERBB2)
BACU: 103002640(ERBB2)
LVE: 103075672(ERBB2)
OOR: 101283619(ERBB2)
DLE: 111166300(ERBB2)
PCAD: 102990192(ERBB2)
PSIU: 116745518(ERBB2)
ECB: 100054739(ERBB2)
EPZ: 103550160(ERBB2)
EAI: 106826341(ERBB2)
MYB: 102243033(ERBB2)
MYD: 102771013(ERBB2)
MMYO: 118671218(ERBB2)
MLF: 102427788(ERBB2)
MNA: 107529006(ERBB2)
PKL: 118702172(ERBB2)
HAI: 109380800(ERBB2)
DRO: 112316215(ERBB2)
SHON: 118978214(ERBB2)
PDIC: 114502459(ERBB2)
PHAS: 123816974(ERBB2)
MMF: 118633888(ERBB2)
RFQ: 117013264(ERBB2)
PALE: 102885300(ERBB2)
PGIG: 120611190(ERBB2)
PVP: 105307498(ERBB2)
RAY: 107520699(ERBB2)
MJV: 108390012(ERBB2)
TOD: 119230565(ERBB2)
SARA: 101540816(ERBB2)
LAV: 100662583(ERBB2)
TMU: 101354844
DNM: 101425577(ERBB2)
MDO: 100017172(ERBB2)
GAS: 123245551(ERBB2)
SHR: 100914727(ERBB2)
PCW: 110215729(ERBB2)
OAA: 100091139(ERBB2)
GGA: 426130(ERBB2)
PCOC: 116233633(ERBB2)
MGP: 100550880(ERBB2)
CJO: 107325215(ERBB2)
NMEL: 110388649(ERBB2)
AFUL: 116498599(ERBB2)
TGU: 101233610
LSR: 110471930(ERBB2)
SCAN: 103821628(ERBB2)
PMOA: 120496682(ERBB2)
OTC: 121347628(ERBB2)
PRUF: 121351120(ERBB2)
FAB: 101818019(ERBB2)
PHI: 102108835(ERBB2)
PMAJ: 107215327(ERBB2)
CCAE: 111944944
CCW: 104697788(ERBB2)
ZAB: 102064221(ERBB2)
FPG: 101914383(ERBB2)
FCH: 102057575(ERBB2)
CLV: 102094013(ERBB2)
NNI: 104013874(ERBB2)
TALA: 116960148(ERBB2)
ACHC: 115344932(ERBB2)
AAM: 106486153(ERBB2)
AROW: 112969537(ERBB2)
NPD: 112949026(ERBB2)
DNE: 112993877(ERBB2)
ASN: 102369818(ERBB2)
AMJ: 102561352(ERBB2)
CPOO: 109320284(ERBB2)
GGN: 109290561(ERBB2)
PSS: 102457099(ERBB2)
CMY: 102946701(ERBB2)
CPIC: 101931763(ERBB2)
TST: 117869182(ERBB2)
CABI: 116831381(ERBB2)
MRV: 120392163(ERBB2)
ACS: 100565910(erbb2)
PVT: 110082059(ERBB2)
SUND: 121933598(ERBB2)
PMUR: 107303070(ERBB2)
TSR: 106538863(ERBB2)
PGUT: 117664667(ERBB2)
VKO: 123031797(ERBB2)
ZVI: 118094199(ERBB2)
GJA: 107114744(ERBB2)
XLA: 108700774(erbb2.L) 108702492
XTR: 100492078(erbb2)
NPR: 108792756(ERBB2)
RTEM: 120918450(ERBB2)
BBUF: 121003142(ERBB2)
BGAR: 122940045(ERBB2)
DRE: 386966(erbb2)
IPU: 108273851(erbb2)
PHYP: 113547490(erbb2)
SMEO: 124389245(erbb2)
AMEX: 103042851(erbb2)
EEE: 113576854(erbb2)
LCO: 104926899(erbb2)
NCC: 104946774(erbb2)
CGOB: 115024277
ELY: 117247291(erbb2)
SLUC: 116061112(erbb2)
ECRA: 117937271(erbb2)
PFLV: 114547884(erbb2)
GAT: 120819148(erbb2)
PPUG: 119212576(erbb2)
MSAM: 119915537(erbb2)
CUD: 121528226(erbb2)
MZE: 101482712(erbb2)
ONL: 100690421
OAU: 116335111(erbb2)
OLA: 101174230
OML: 112154010(erbb2)
XMA: 102234046(erbb2)
XCO: 114152068(erbb2)
XHE: 116726742(erbb2)
PRET: 103481805
PFOR: 103152369(erbb2)
PLAI: 106956127(erbb2)
PMEI: 106925971(erbb2)
GAF: 122823551(erbb2)
CVG: 107085581(erbb2)
CTUL: 119792246(erbb2)
GMU: 124875242(erbb2)
NFU: 107387934
KMR: 108248942(erbb2)
ALIM: 106521372(erbb2)
NWH: 119423986(erbb2)
AOCE: 111577732
CSEM: 103381605(erbb2)
POV: 109641267(erbb2)
SSEN: 122762905(erbb2)
HHIP: 117752732(erbb2)
LCF: 108890417(erbb2)
SDU: 111219739(erbb2)
SLAL: 111652260(erbb2)
XGL: 120794240(erbb2)
HCQ: 109523903(erbb2)
BPEC: 110171045(erbb2)
MALB: 109973611(erbb2)
SASA: 106579080(erbb2)
OTW: 112223875(erbb2)
OMY: 110491754(erbb2)
OGO: 124048486(erbb2)
ONE: 115106706(erbb2)
SALP: 111977625(erbb2)
SNH: 120046383(erbb2)
ELS: 105030222(erbb2)
SFM: 108919192(erbb2) 108922533
PKI: 111837750 111854099(erbb2)
AANG: 118220322(erbb2)
LOC: 102686895(erbb2)
LCM: 102348821(ERBB2)
CMK: 103183785(erbb2)
RTP: 109930473
CIN: 778955(egfr1)
 » show all
Reference
PMID:3003577
  Authors
Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, Saito T, Toyoshima K
  Title
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.
  Journal
Nature 319:230-4 (1986)
DOI:10.1038/319230a0
  Sequence
[hsa:2064]
LinkDB

KEGG   ORTHOLOGY: K05084
Entry
K05084                      KO                                     
Symbol
ERBB3, HER3
Name
receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
Disease
H00408  Type 1 diabetes mellitus
H00865  Lethal congenital contractural syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   04012 ErbB signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   04020 Calcium signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   04151 PI3K-Akt signaling pathway
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
   05205 Proteoglycans in cancer
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K05084  ERBB3, HER3; receptor tyrosine-protein kinase erbB-3
Genes
HSA: 2065(ERBB3)
PTR: 451980(ERBB3)
PPS: 100974494(ERBB3)
GGO: 109025126(ERBB3)
PON: 100174431(ERBB3)
NLE: 100590102(ERBB3)
MCC: 711407(ERBB3)
MCF: 102115998(ERBB3)
CSAB: 103238504(ERBB3)
CATY: 105587314(ERBB3)
PANU: 101003778(ERBB3)
TGE: 112634585(ERBB3)
RRO: 104673694(ERBB3)
RBB: 108515999(ERBB3)
TFN: 117089952(ERBB3)
PTEH: 111541863(ERBB3)
CJC: 100409758(ERBB3)
SBQ: 101030064(ERBB3)
CSYR: 103271002
MMUR: 105865027(ERBB3)
OGA: 100966253(ERBB3)
MMU: 13867(Erbb3)
MCAL: 110302668(Erbb3)
MPAH: 110326297(Erbb3)
RNO: 29496(Erbb3)
MCOC: 116076169(Erbb3)
MUN: 110559383(Erbb3)
CGE: 100767681(Erbb3)
PLEU: 114681754(Erbb3)
NGI: 103746501(Erbb3)
HGL: 101721671(Erbb3)
CPOC: 100712946(Erbb3)
CCAN: 109686062(Erbb3)
DORD: 105989461(Erbb3)
DSP: 122124201(Erbb3)
OCU: 100008807(ERBB3)
OPI: 101517747(ERBB3)
TUP: 102468023(ERBB3)
CFA: 481105(ERBB3)
VVP: 112922396(ERBB3)
VLG: 121490972(ERBB3)
AML: 100468735(ERBB3)
UMR: 103656927(ERBB3)
UAH: 113256440(ERBB3)
UAR: 123787262(ERBB3)
ELK: 111160180
LLV: 125106206
MPUF: 101680042(ERBB3)
ORO: 101385903(ERBB3)
EJU: 114215065(ERBB3)
ZCA: 113921413(ERBB3)
MLX: 118008728(ERBB3)
FCA: 101085388(ERBB3)
PYU: 121040944(ERBB3)
PBG: 122473747(ERBB3)
PTG: 102948909(ERBB3)
PPAD: 109270315(ERBB3)
AJU: 106986858(ERBB3)
HHV: 120219930(ERBB3)
BTA: 785655(ERBB3)
BOM: 102273820(ERBB3)
BIU: 109559378(ERBB3)
BBUB: 102395621(ERBB3)
CHX: 102173448(ERBB3)
OAS: 101103889(ERBB3)
ODA: 120857431(ERBB3)
CCAD: 122427060(ERBB3)
SSC: 100525045(ERBB3)
CFR: 102506629(ERBB3)
CBAI: 105075904(ERBB3)
CDK: 105086379(ERBB3)
VPC: 102541044(ERBB3)
BACU: 103015964(ERBB3)
LVE: 103087241(ERBB3)
OOR: 101288152(ERBB3)
DLE: 111173887(ERBB3)
PCAD: 102975550(ERBB3)
PSIU: 116761086(ERBB3)
ECB: 100059216(ERBB3)
EPZ: 103557568(ERBB3)
EAI: 106832936(ERBB3)
MYB: 102248465(ERBB3)
MYD: 102774755(ERBB3)
MMYO: 118650120(ERBB3)
MLF: 102438329(ERBB3)
MNA: 107546211(ERBB3)
PKL: 118728255(ERBB3)
HAI: 109396911(ERBB3)
DRO: 112319025(ERBB3)
SHON: 118976014(ERBB3)
AJM: 119048554(ERBB3)
PDIC: 114512713(ERBB3)
PHAS: 123812915(ERBB3)
MMF: 118624257(ERBB3)
RFQ: 117028913(ERBB3)
PALE: 102895392(ERBB3)
PGIG: 120604897(ERBB3)
PVP: 105302594(ERBB3)
RAY: 107521255(ERBB3)
MJV: 108398133(ERBB3)
TOD: 119248041(ERBB3)
SARA: 101545451(ERBB3)
LAV: 100668973(ERBB3)
TMU: 101354434
DNM: 101418944(ERBB3)
MDO: 100028072 100028103(ERBB3)
SHR: 100924586
PCW: 110210914
OAA: 100079793(ERBB3)
GGA: 693245(ERBB3)
PCOC: 116239283(ERBB3)
CJO: 107325755(ERBB3)
NMEL: 110389140(ERBB3)
ACYG: 106029359
AFUL: 116500019(ERBB3)
TGU: 115491473(ERBB3)
LSR: 110482393(ERBB3)
PMOA: 120505872(ERBB3)
PHI: 102101993(ERBB3)
ETL: 114070808(ERBB3)
FPG: 101914106(ERBB3)
FCH: 102056537
NNI: 104017527(ERBB3)
TALA: 116961457(ERBB3)
ACHC: 115350855(ERBB3)
ASN: 102376821(ERBB3)
AMJ: 102577159(ERBB3)
PSS: 102454909(ERBB3)
CPIC: 101942522(ERBB3)
TST: 117888990(ERBB3)
CABI: 116827815(ERBB3)
MRV: 120390926(ERBB3)
ACS: 100556326(erbb3)
PVT: 110073465(ERBB3)
SUND: 121923916(ERBB3)
PBI: 103051488(ERBB3)
PMUR: 107284855(ERBB3)
TSR: 106555502(ERBB3)
PGUT: 117662893(ERBB3)
VKO: 123033111(ERBB3)
PMUA: 114587816(ERBB3)
ZVI: 118079615(ERBB3)
GJA: 107108277(ERBB3)
XLA: 108708565(erbb3.L) 108709833(erbb3.S)
XTR: 100493384(erbb3)
NPR: 108790515(ERBB3)
RTEM: 120929532(ERBB3)
BBUF: 120995995(ERBB3)
BGAR: 122930772(ERBB3)
DRE: 100149258 386635(erbb3a) 544664(erbb3b)
CCAR: 109104287
IPU: 108271615(erbb3a) 108276025(erbb3b)
PHYP: 113527462(erbb3) 113530351
SMEO: 124386295(erbb3a) 124399044(erbb3b)
AMEX: 103028053(erbb3) 103032103
EEE: 113581376 113581542(erbb3)
TRU: 101061551 101069394(erbb3)
LCO: 104932439 104938399(erbb3)
NCC: 104941411(erbb3) 104956941
CGOB: 115008140(erbb3) 115010612
ELY: 117257063(erbb3a) 117257630(erbb3b)
PLEP: 121947136(erbb3b) 121955848(erbb3a)
SLUC: 116038790(erbb3b) 116041689(erbb3a)
ECRA: 117944075(erbb3a) 117947750(erbb3b)
PFLV: 114554019(erbb3) 114559209
GAT: 120829080(erbb3b) 120835587(erbb3a)
PPUG: 119194240(erbb3a) 119199286
MSAM: 119886809(erbb3a) 119906034(erbb3b)
CUD: 121507170(erbb3a) 121518167(erbb3b)
OAU: 116325811(erbb3b) 116333795
OLA: 101172402(erbb3) 101172978
OML: 112144829 112159600(erbb3b)
XMA: 102225708 102230188(erbb3)
XHE: 116710979(erbb3) 116727336
PRET: 103465260(erbb3) 103467364
PLAI: 106954775(erbb3) 106955349
GAF: 122828517(erbb3b) 122834715
CVG: 107082131(erbb3) 107092166
CTUL: 119776657(erbb3a) 119785035(erbb3b)
GMU: 124857405(erbb3a) 124874066(erbb3b)
NFU: 107385695(erbb3) 107390894
KMR: 108235300(erbb3b) 108235724(erbb3a)
ALIM: 106518025(erbb3) 106536334
NWH: 119411926(erbb3a) 119416957(erbb3b)
SSEN: 122768406(erbb3a) 122776600(erbb3b)
HHIP: 117761286(erbb3a) 117764120(erbb3b)
LCF: 108876575 108881471(erbb3)
SDU: 111219064 111221725(erbb3)
SLAL: 111667812(erbb3) 111668898
XGL: 120783170(erbb3a) 120803750(erbb3b)
HCQ: 109522344(erbb3) 109531391
BPEC: 110164957 110168364(erbb3)
MALB: 109964444(erbb3) 109971109
PKI: 111854164(erbb3)
LOC: 102684317(erbb3)
PSPA: 121309044(erbb3a)
LCM: 102353616(ERBB3)
 » show all
Reference
PMID:2687875
  Authors
Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA
  Title
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.
  Journal
Proc Natl Acad Sci U S A 86:9193-7 (1989)
DOI:10.1073/pnas.86.23.9193
  Sequence
[hsa:2065]
LinkDB

KEGG   ORTHOLOGY: K05085
Entry
K05085                      KO                                     
Symbol
ERBB4, HER4
Name
receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map05014  Amyotrophic lateral sclerosis
map05205  Proteoglycans in cancer
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
   04012 ErbB signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
   04020 Calcium signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
   04151 PI3K-Akt signaling pathway
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K05085  ERBB4, HER4; receptor tyrosine-protein kinase erbB-4
Genes
HSA: 2066(ERBB4)
PTR: 459919(ERBB4)
PPS: 100996186(ERBB4)
GGO: 101131773(ERBB4)
PON: 100938677(ERBB4)
NLE: 100598496(ERBB4)
MCC: 693341(ERBB4)
MCF: 102141308(ERBB4)
CSAB: 103217777(ERBB4)
CATY: 105580144(ERBB4)
PANU: 100998445(ERBB4)
TGE: 112636548(ERBB4)
RRO: 104658903(ERBB4)
RBB: 108517585(ERBB4)
TFN: 117094169
PTEH: 111548039(ERBB4)
CJC: 100402965(ERBB4)
SBQ: 101049355(ERBB4)
CSYR: 103260440(ERBB4)
MMUR: 105862314(ERBB4)
OGA: 100950688(ERBB4)
MMU: 13869(Erbb4)
MCAL: 110312376(Erbb4)
MPAH: 110321248(Erbb4)
RNO: 59323(Erbb4)
MCOC: 116088530(Erbb4)
CGE: 100760475
PLEU: 114693631(Erbb4)
NGI: 103744489(Erbb4)
HGL: 101725806(Erbb4)
CPOC: 100724678(Erbb4)
DORD: 105982090(Erbb4)
DSP: 122107486(Erbb4)
OCU: 100009328(ERBB4)
OPI: 101534591(ERBB4)
TUP: 102482008(ERBB4)
CFA: 488508(ERBB4)
VVP: 112922459(ERBB4)
VLG: 121480598(ERBB4)
AML: 100470612(ERBB4)
UMR: 103659965(ERBB4)
UAH: 113250501(ERBB4)
UAR: 123798269(ERBB4)
ELK: 111138855
LLV: 125095556
MPUF: 101672764(ERBB4)
ORO: 101371484
EJU: 114215947(ERBB4)
ZCA: 113920155(ERBB4)
MLX: 118012082(ERBB4)
FCA: 101100073(ERBB4)
PYU: 121031014(ERBB4)
PBG: 122481727(ERBB4)
PTG: 102950188(ERBB4)
PPAD: 109265121(ERBB4)
AJU: 106974147(ERBB4)
HHV: 120245818(ERBB4)
BTA: 522419(ERBB4)
BOM: 102265783(ERBB4)
BBUB: 102400549(ERBB4)
CHX: 102180167(ERBB4)
OAS: 101103044
ODA: 120854102
CCAD: 122426466(ERBB4)
SSC: 100525789(ERBB4)
CFR: 102522654(ERBB4)
CBAI: 105072941(ERBB4)
CDK: 105099620(ERBB4)
VPC: 102544772(ERBB4)
BACU: 103004826(ERBB4)
LVE: 103078350(ERBB4)
OOR: 101278439(ERBB4)
DLE: 111171792(ERBB4)
PCAD: 102975726(ERBB4)
PSIU: 116756965(ERBB4)
ECB: 100050182(ERBB4)
EPZ: 103558743
EAI: 106837675(ERBB4)
MYB: 102241613(ERBB4)
MYD: 102765674(ERBB4)
MMYO: 118661478(ERBB4)
MLF: 102442922(ERBB4)
MNA: 107524731(ERBB4)
PKL: 118709193(ERBB4)
HAI: 109390432(ERBB4)
DRO: 112307700(ERBB4)
SHON: 118984230(ERBB4)
AJM: 119044331(ERBB4)
PDIC: 114494770(ERBB4)
PHAS: 123828079(ERBB4)
MMF: 118625188(ERBB4)
RFQ: 117026370(ERBB4)
PALE: 102895574(ERBB4)
PGIG: 120587606
PVP: 105291094(ERBB4)
RAY: 107517636(ERBB4)
MJV: 108400921
TOD: 119255187(ERBB4)
SARA: 101557114(ERBB4)
LAV: 100656755(ERBB4)
TMU: 101360755
DNM: 101441399
MDO: 100014865(ERBB4)
GAS: 123242724(ERBB4)
SHR: 100931663(ERBB4)
PCW: 110223279(ERBB4)
OAA: 100077353(ERBB4)
GGA: 395671(ERBB4)
PCOC: 116235913(ERBB4)
MGP: 100539508(ERBB4)
CJO: 107316482(ERBB4)
NMEL: 110399647(ERBB4)
APLA: 101801144(ERBB4)
ACYG: 106034472(ERBB4)
AFUL: 116490568(ERBB4)
TGU: 100231016(ERBB4)
LSR: 110478436(ERBB4)
SCAN: 103814752(ERBB4)
PMOA: 120511492(ERBB4)
OTC: 121339684(ERBB4)
PRUF: 121364430(ERBB4)
GFR: 102045033(ERBB4)
FAB: 101808540(ERBB4)
PHI: 102113512(ERBB4)
PMAJ: 107207560(ERBB4)
CCAE: 111931698 111931870(ERBB4)
CCW: 104694541(ERBB4)
ETL: 114062626(ERBB4)
ZAB: 102064627(ERBB4)
FPG: 101910610(ERBB4)
FCH: 102046664(ERBB4)
CLV: 102091363(ERBB4)
EGZ: 104124291(ERBB4)
NNI: 104010094(ERBB4)
ACUN: 113482047(ERBB4)
TALA: 104359725(ERBB4)
PADL: 103921667(ERBB4)
ACHC: 115342928(ERBB4)
AAM: 106492330(ERBB4)
AROW: 112976707(ERBB4)
NPD: 112955177(ERBB4)
DNE: 112979245(ERBB4)
ASN: 102387680(ERBB4)
AMJ: 102559834(ERBB4)
CPOO: 109322736(ERBB4)
GGN: 109301656(ERBB4)
CMY: 102939092(ERBB4)
CPIC: 101941047(ERBB4)
TST: 117885003(ERBB4)
CABI: 116837850(ERBB4)
MRV: 120374435(ERBB4)
ACS: 100558986(erbb4)
PVT: 110072384(ERBB4)
SUND: 121919152(ERBB4)
PBI: 103055996(ERBB4)
PMUR: 107301863(ERBB4)
PGUT: 117675245(ERBB4)
VKO: 123024389(ERBB4)
PMUA: 114583404(ERBB4)
ZVI: 118096713(ERBB4)
GJA: 107120657(ERBB4)
XLA: 108703039 724070(erbb4.L)
XTR: 100493234(erbb4)
NPR: 108792763(ERBB4)
RTEM: 120944427(ERBB4)
BBUF: 121007601(ERBB4)
BGAR: 122944375(ERBB4)
DRE: 100007677(erbb4a) 101885162(si:ch73-383l1.1) 569836(erbb4b)
CCAR: 109052551
AMEX: 103033543(erbb4) 103038099
EEE: 113579187(erbb4) 113579192
TRU: 101074687 101079286(erbb4)
LCO: 104928902 104929362(erbb4)
NCC: 104953634(erbb4)
ELY: 117249751 117250770(erbb4b)
PLEP: 121949565(erbb4b) 121963010
PFLV: 114550836 114563973(erbb4)
GAT: 120825010(si:ch73-383l1.1) 120833897
MSAM: 119903962(erbb4b) 119904608
MZE: 101467929(erbb4) 101478875
OAU: 116312076 116332215(si:ch73-383l1.1)
OLA: 101165111(erbb4) 101165379
OML: 112155138 112156664(si:ch73-383l1.1)
XMA: 102230380(erbb4) 102231767
XCO: 114140872(erbb4) 114148479
XHE: 116716082(erbb4) 116723227
PRET: 103461563 103476823(erbb4)
PLAI: 106948936(erbb4) 106956630
PMEI: 106918512(erbb4) 106923420
CVG: 107084231 107088040(erbb4)
NWH: 119418845(erbb4b) 119429101
CSEM: 103389576(erbb4) 103392212
POV: 109631409(erbb4)
LCF: 108873032(erbb4) 108880453
SLAL: 111662725 111665293(erbb4)
HCQ: 109528703(erbb4) 109531201
BPEC: 110156208 110170911(erbb4)
MALB: 109968758(erbb4)
OTW: 112224855 112238881 112240957(si:ch73-383l1.1)
ONE: 115111274
SALP: 112068952
SFM: 108922269 108928922(erbb4)
LOC: 102686973(erbb4)
LCM: 102360220(ERBB4)
RTP: 109923881
CIN: 778964
SKO: 100313534
 » show all
Reference
PMID:8383326
  Authors
Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M
  Title
Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.
  Journal
Proc Natl Acad Sci U S A 90:1746-50 (1993)
DOI:10.1073/pnas.90.5.1746
  Sequence
[hsa:2066]
Reference
  Authors
Holbro T, Hynes NE.
  Title
ErbB receptors: directing key signaling networks throughout life.
  Journal
Annu Rev Pharmacol Toxicol 44:195-217 (2004)
DOI:10.1146/annurev.pharmtox.44.101802.121440
Reference
  Authors
Citri A, Yarden Y.
  Title
EGF-ERBB signalling: towards the systems level.
  Journal
Nat Rev Mol Cell Biol 7:505-16 (2006)
DOI:10.1038/nrm1962
LinkDB

KEGG   ORTHOLOGY: K04363
Entry
K04363                      KO                                     
Symbol
PDGFRA, CD140A
Name
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04072  Phospholipase D signaling pathway
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04630  JAK-STAT signaling pathway
map04810  Regulation of actin cytoskeleton
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01590  Chronic eosinophilic leukemia
H01591  Gastrotintestinal stromal tumor
H01599  Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 JAK-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09162 Cancer: specific types
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
Other DBs
GO: 0005018
Genes
HSA: 5156(PDGFRA)
PTR: 461318(PDGFRA)
PPS: 100982337(PDGFRA)
GGO: 101124928(PDGFRA)
PON: 100431735(PDGFRA)
NLE: 100603207(PDGFRA)
MCC: 697002(PDGFRA)
MCF: 102138392(PDGFRA)
CSAB: 103235675(PDGFRA)
CATY: 105592013(PDGFRA)
PANU: 101022081(PDGFRA)
TGE: 112625154(PDGFRA)
RRO: 104658857(PDGFRA)
RBB: 108533750(PDGFRA)
TFN: 117085606(PDGFRA)
PTEH: 111520430(PDGFRA)
CJC: 100412331(PDGFRA)
SBQ: 101040156(PDGFRA)
CSYR: 103249185(PDGFRA)
MMUR: 105867837(PDGFRA)
OGA: 100961338(PDGFRA)
MMU: 18595(Pdgfra)
MCAL: 110295292(Pdgfra)
MPAH: 110331028(Pdgfra)
RNO: 25267(Pdgfra)
MCOC: 116071260(Pdgfra)
MUN: 110558105(Pdgfra)
CGE: 100760258(Pdgfra)
PLEU: 114683759(Pdgfra)
NGI: 103734393(Pdgfra)
HGL: 101697360(Pdgfra)
CPOC: 100726209(Pdgfra)
CCAN: 109685094(Pdgfra) 109702274
DORD: 105980318(Pdgfra)
DSP: 122106871(Pdgfra)
OCU: 100343006(PDGFRA)
OPI: 101516125(PDGFRA)
TUP: 102488187(PDGFRA)
CFA: 442860(PDGFRA)
VVP: 112933353(PDGFRA)
VLG: 121472891(PDGFRA)
AML: 100464991(PDGFRA)
UMR: 103672737(PDGFRA)
UAH: 113262493(PDGFRA)
UAR: 123804080(PDGFRA)
ELK: 111148924
LLV: 125093724
MPUF: 101684479(PDGFRA)
ORO: 101372359(PDGFRA)
EJU: 114206758(PDGFRA)
ZCA: 113925340(PDGFRA)
MLX: 118010522(PDGFRA)
FCA: 101090765(PDGFRA)
PYU: 121035565(PDGFRA)
PBG: 122478872(PDGFRA)
PTG: 102955481(PDGFRA)
PPAD: 109278988(PDGFRA)
AJU: 106983998(PDGFRA)
HHV: 120222584(PDGFRA)
BTA: 282301(PDGFRA)
BOM: 102282598(PDGFRA)
BIU: 109560475(PDGFRA)
BBUB: 102409620(PDGFRA)
CHX: 102174007(PDGFRA)
OAS: 101106012(PDGFRA)
ODA: 120862113(PDGFRA)
CCAD: 122427991(PDGFRA)
SSC: 100627123(PDGFRA)
CFR: 102512589(PDGFRA)
CBAI: 105077672(PDGFRA)
CDK: 105103397(PDGFRA)
VPC: 102528303(PDGFRA)
BACU: 102998016(PDGFRA)
LVE: 103071473(PDGFRA)
OOR: 101269459(PDGFRA)
DLE: 111169692(PDGFRA)
PCAD: 102994349(PDGFRA)
PSIU: 116754045(PDGFRA)
ECB: 100059815(PDGFRA)
EPZ: 103552305(PDGFRA)
EAI: 106839051(PDGFRA)
MYB: 102255326(PDGFRA)
MYD: 102761943(PDGFRA)
MMYO: 118668634(PDGFRA)
MLF: 102417415(PDGFRA)
MNA: 107532710(PDGFRA)
PKL: 118706667(PDGFRA)
HAI: 109381815(PDGFRA)
DRO: 112316918(PDGFRA)
SHON: 118978642(PDGFRA)
AJM: 119054288(PDGFRA)
PDIC: 114493180(PDGFRA)
PHAS: 123815579(PDGFRA)
MMF: 118624129(PDGFRA)
RFQ: 117022011(PDGFRA)
PALE: 102895362(PDGFRA)
PGIG: 120588066(PDGFRA)
PVP: 105293808(PDGFRA)
RAY: 107499793(PDGFRA)
MJV: 108385741(PDGFRA)
TOD: 119261223(PDGFRA)
SARA: 101539850(PDGFRA)
LAV: 100670735(PDGFRA)
TMU: 101348884
DNM: 101428297(PDGFRA)
MDO: 100013088(PDGFRA)
GAS: 123252399(PDGFRA)
SHR: 100925116(PDGFRA)
PCW: 110200158(PDGFRA)
OAA: 100084432(PDGFRA)
GGA: 395509(PDGFRA)
PCOC: 116225916(PDGFRA)
MGP: 100542010(PDGFRA)
CJO: 107313741(PDGFRA)
NMEL: 110397725(PDGFRA)
APLA: 101797285(PDGFRA)
ACYG: 106030788(PDGFRA)
AFUL: 116488453(PDGFRA)
TGU: 100218386(PDGFRA)
LSR: 110469831(PDGFRA)
SCAN: 103825217(PDGFRA)
PMOA: 120497403(PDGFRA)
OTC: 121334956(PDGFRA)
PRUF: 121349389(PDGFRA)
GFR: 102044274(PDGFRA)
FAB: 101820996(PDGFRA)
PHI: 102113476(PDGFRA)
PMAJ: 107203533(PDGFRA)
CCAE: 111928019(PDGFRA)
CCW: 104690630(PDGFRA)
ETL: 114058301(PDGFRA)
ZAB: 102070900 102075453(PDGFRA)
FPG: 101913531(PDGFRA)
FCH: 102054310(PDGFRA)
CLV: 102087625(PDGFRA)
EGZ: 104129386(PDGFRA)
NNI: 104020776(PDGFRA)
ACUN: 113479434(PDGFRA)
TALA: 104362833(PDGFRA)
PADL: 103926287(PDGFRA)
ACHC: 115341064(PDGFRA)
AAM: 106490172(PDGFRA)
AROW: 112974613(PDGFRA)
NPD: 112942568(PDGFRA)
DNE: 112979490(PDGFRA)
ASN: 102378120(PDGFRA)
AMJ: 102575338(PDGFRA)
CPOO: 109322084(PDGFRA)
GGN: 109303887(PDGFRA)
PSS: 102443708(PDGFRA)
CMY: 102935642(PDGFRA)
CPIC: 101935558(PDGFRA)
TST: 117878037(PDGFRA)
CABI: 116821225(PDGFRA)
MRV: 120407146(PDGFRA)
ACS: 100565834(pdgfra)
PVT: 110078407(PDGFRA)
SUND: 121930753(PDGFRA)
PBI: 103067713(PDGFRA)
PMUR: 107298631(PDGFRA)
PGUT: 117662144(PDGFRA)
VKO: 123016964(PDGFRA)
PMUA: 114604335(PDGFRA)
ZVI: 118083576(PDGFRA)
GJA: 107106036(PDGFRA)
XLA: 108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 100124862(pdgfra)
NPR: 108804111(PDGFRA)
RTEM: 120922903(PDGFRA)
BBUF: 120990209(PDGFRA)
BGAR: 122941740(PDGFRA)
DRE: 386856(pdgfra)
CCAR: 109112741
IPU: 108258040(pdgfra)
PHYP: 113546841(pdgfra)
SMEO: 124377156(pdgfra)
AMEX: 103044267(pdgfra)
EEE: 113586382(pdgfra)
TRU: 101073543(pdgfra)
LCO: 104919088(pdgfra)
NCC: 104947073(pdgfra)
CGOB: 115006742(pdgfra)
ELY: 117253552(pdgfra)
PLEP: 121940421(pdgfra)
SLUC: 116058814(pdgfra)
ECRA: 117950139(pdgfra)
PFLV: 114561192(pdgfra)
GAT: 120824143(pdgfra)
PPUG: 119216932(pdgfra)
MSAM: 119901064(pdgfra)
CUD: 121512171(pdgfra)
MZE: 101471693(pdgfra)
ONL: 100692594(pdgfra)
OAU: 116331096(pdgfra)
OLA: 100049280(pdgfra)
OML: 112137012(pdgfra)
XMA: 102219876(pdgfra)
XCO: 114151105(pdgfra)
XHE: 116726146(pdgfra)
PRET: 103463840(pdgfra)
PFOR: 103137117(pdgfra)
PLAI: 106963502(pdgfra)
PMEI: 106924185(pdgfra)
GAF: 122838005(pdgfra)
CVG: 107091563(pdgfra)
CTUL: 119780613(pdgfra)
GMU: 124873707(pdgfra)
NFU: 107393382(pdgfra)
KMR: 108243392(pdgfra)
ALIM: 106524096(pdgfra)
NWH: 119430861(pdgfra)
AOCE: 111569607(pdgfra)
CSEM: 103376707(pdgfra)
POV: 109625664(pdgfra)
SSEN: 122780311(pdgfra)
HHIP: 117760248(pdgfra)
LCF: 108879100(pdgfra)
SDU: 111226338(pdgfra)
SLAL: 111644345(pdgfra)
XGL: 120790742(pdgfra)
HCQ: 109532287(pdgfra)
BPEC: 110154688(pdgfra)
MALB: 109962087(pdgfra)
SASA: 106560269 106584117(pdgfra)
OTW: 112249110(pdgfra) 112251129
OMY: 110521671(pdgfra) 110523003
OGO: 123996500 124037857(pdgfra)
ONE: 115108534 115145127(pdgfra)
SALP: 111972315(pdgfra) 111976174
SNH: 120052582(pdgfra) 120054283
ELS: 105011836(pdgfra)
SFM: 108922803(pdgfra)
PKI: 111850064
AANG: 118225723(pdgfra)
LOC: 102682229(pdgfra)
LCM: 102353753(PDGFRA)
CMK: 103178167(pdgfra)
RTP: 109927411(pdgfra)
CGLO: 123271713
DMK: 116920053
PCLA: 123762807
DFR: 124497508
NVE: 5507990
PDAM: 113683455
 » show all
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]
LinkDB

KEGG   ORTHOLOGY: K05089
Entry
K05089                      KO                                     
Symbol
PDGFRB, CD140B
Name
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04072  Phospholipase D signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04630  JAK-STAT signaling pathway
map04810  Regulation of actin cytoskeleton
map05165  Human papillomavirus infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
H01910  Infantile myofibromatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 JAK-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09162 Cancer: specific types
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
Other DBs
GO: 0004992
Genes
HSA: 5159(PDGFRB)
PTR: 462188(PDGFRB)
PPS: 100975853(PDGFRB)
GGO: 101150577(PDGFRB)
PON: 100460001(PDGFRB)
NLE: 100597894(PDGFRB)
MCC: 711353(PDGFRB)
MCF: 101867161(PDGFRB)
CSAB: 103244790(PDGFRB)
CATY: 105589876(PDGFRB)
PANU: 101008264(PDGFRB)
TGE: 112626117(PDGFRB)
RRO: 104670408(PDGFRB)
RBB: 108532047(PDGFRB)
TFN: 117065596(PDGFRB)
PTEH: 111552670(PDGFRB)
CJC: 100389852(PDGFRB)
SBQ: 101040158(PDGFRB)
CSYR: 103263367(PDGFRB)
MMUR: 105858450(PDGFRB)
OGA: 100951606(PDGFRB)
MMU: 18596(Pdgfrb)
MCAL: 110284880(Pdgfrb)
MPAH: 110333065(Pdgfrb)
RNO: 24629(Pdgfrb)
MCOC: 116087226(Pdgfrb)
MUN: 110546695(Pdgfrb)
CGE: 100764374(Pdgfrb)
PLEU: 114707365(Pdgfrb)
NGI: 103747076(Pdgfrb)
HGL: 101721151(Pdgfrb)
CPOC: 100726506(Pdgfrb)
CCAN: 109685664(Pdgfrb)
DORD: 105992616(Pdgfrb)
DSP: 122118168(Pdgfrb)
OCU: 100342872(PDGFRB)
OPI: 101516431(PDGFRB)
TUP: 102492413(PDGFRB)
CFA: 442985(PDGFRB)
VVP: 112927357(PDGFRB)
VLG: 121486777(PDGFRB)
AML: 100472005(PDGFRB)
UMR: 103664600(PDGFRB)
UAH: 113263944(PDGFRB)
UAR: 123803639(PDGFRB)
ELK: 111140848
LLV: 125100170
MPUF: 101684361(PDGFRB)
ORO: 101374793(PDGFRB)
EJU: 114211916(PDGFRB)
ZCA: 113929051(PDGFRB)
FCA: 101084600(PDGFRB)
PYU: 121045013(PDGFRB)
PBG: 122493456(PDGFRB)
PTG: 102954207(PDGFRB)
PPAD: 109275948(PDGFRB)
AJU: 106985388(PDGFRB)
HHV: 120236611(PDGFRB)
BTA: 527165(PDGFRB)
BOM: 102270608(PDGFRB)
BIU: 109562197(PDGFRB)
BBUB: 102392216(PDGFRB)
CHX: 102184426(PDGFRB)
OAS: 101122783(PDGFRB)
ODA: 120863403(PDGFRB)
CCAD: 122439706(PDGFRB)
SSC: 102166564(PDGFRB)
CFR: 102512951(PDGFRB)
CBAI: 105074292(PDGFRB)
CDK: 105098486(PDGFRB)
VPC: 102545129(PDGFRB)
BACU: 103019883(PDGFRB)
LVE: 103082363(PDGFRB)
OOR: 101272795(PDGFRB)
DLE: 111183086(PDGFRB)
PCAD: 102995915(PDGFRB)
PSIU: 116751332(PDGFRB)
ECB: 100071665(PDGFRB)
EPZ: 103549125(PDGFRB)
EAI: 106838493(PDGFRB)
MYB: 102241145(PDGFRB)
MYD: 102764172(PDGFRB)
MMYO: 118658697(PDGFRB)
MLF: 102441579(PDGFRB)
MNA: 107535230(PDGFRB)
PKL: 118711223(PDGFRB)
HAI: 109375002(PDGFRB)
DRO: 112319577(PDGFRB)
SHON: 118986157(PDGFRB)
AJM: 119061365(PDGFRB)
PDIC: 114509632(PDGFRB)
PHAS: 123807517(PDGFRB)
MMF: 118615300(PDGFRB)
RFQ: 117016666(PDGFRB)
PALE: 102887643(PDGFRB)
PGIG: 120581545(PDGFRB)
PVP: 105299436(PDGFRB)
RAY: 107497163(PDGFRB)
MJV: 108385397(PDGFRB)
TOD: 119243270(PDGFRB)
SARA: 101540263(PDGFRB)
LAV: 100671240(PDGFRB)
TMU: 101360003
DNM: 101411552(PDGFRB)
MDO: 100028943(PDGFRB)
GAS: 123233823(PDGFRB)
SHR: 100917212(PDGFRB)
PCW: 110192821(PDGFRB)
OAA: 100079459(PDGFRB)
GGA: 770488(PDGFRB)
PCOC: 116232153(PDGFRB)
MGP: 100550611(PDGFRB)
CJO: 107320191(PDGFRB)
NMEL: 110405265(PDGFRB)
APLA: 101799587(PDGFRB)
ACYG: 106032823(PDGFRB)
AFUL: 116494711(PDGFRB)
TGU: 100223375(PDGFRB)
LSR: 110482721(PDGFRB)
SCAN: 103817301(PDGFRB)
PMOA: 120498517(PDGFRB)
OTC: 121332255(PDGFRB)
PRUF: 121361297(PDGFRB)
GFR: 102045343(PDGFRB)
FAB: 101809926(PDGFRB)
PHI: 102111524(PDGFRB)
PMAJ: 107210844(PDGFRB)
CCAE: 111935543(PDGFRB)
CCW: 104689579(PDGFRB)
ETL: 114063193(PDGFRB)
ZAB: 102073695(PDGFRB)
FPG: 101918438(PDGFRB)
FCH: 102052718(PDGFRB)
CLV: 102096790(PDGFRB)
EGZ: 104123312(PDGFRB)
NNI: 104014196(PDGFRB)
ACUN: 113485173(PDGFRB)
TALA: 104357574(PDGFRB)
PADL: 103915745(PDGFRB)
ACHC: 115334242(PDGFRB)
AAM: 106493441(PDGFRB)
AROW: 112964785(PDGFRB)
NPD: 112954304(PDGFRB)
DNE: 112996927(PDGFRB)
ASN: 102372962(PDGFRB)
AMJ: 102566175(PDGFRB)
CPOO: 109310161(PDGFRB)
GGN: 109289892(PDGFRB)
PSS: 102460895(PDGFRB)
CMY: 102944650(PDGFRB)
CPIC: 101940553(PDGFRB)
CABI: 116819978(PDGFRB)
MRV: 120369946(PDGFRB)
ACS: 100555784(pdgfrb)
PVT: 110086089(PDGFRB)
SUND: 121923103(PDGFRB)
PBI: 103051588(PDGFRB)
PMUR: 107294993
TSR: 106547766(PDGFRB)
PGUT: 117655249(PDGFRB)
VKO: 123035769(PDGFRB)
PMUA: 114591343(PDGFRB)
ZVI: 118080419(PDGFRB)
XLA: 108712643(pdgfrb.S)
XTR: 100487523(pdgfrb)
NPR: 108785807(PDGFRB)
RTEM: 120932546(PDGFRB)
BBUF: 121008278(PDGFRB)
BGAR: 122928360(PDGFRB)
DRE: 559529(pdgfrb)
IPU: 108274697(pdgfrb)
PHYP: 113529620(pdgfrb)
SMEO: 124392347(pdgfrb)
AMEX: 103036483
EEE: 113575581(pdgfrb)
TRU: 101061130 101074724(pdgfrb)
NCC: 104965701(pdgfrb)
CGOB: 115014733(pdgfrb) 115019444
ELY: 117260792(pdgfrb) 117270921
PLEP: 121939111 121947843(pdgfrb)
SLUC: 116062368 116064307(pdgfrb)
ECRA: 117951210(pdgfrb)
PFLV: 114562615(pdgfrb) 114566403
GAT: 120817382(pdgfrb)
PPUG: 119210567(pdgfrb)
CUD: 121516062(pdgfrb) 121519179
MZE: 101466822 101484671(pdgfrb)
ONL: 100695603(pdgfrb) 100709470
OAU: 116329079(pdgfrb) 116329738
OLA: 101155039(pdgfrb) 101156428
OML: 112136844 112153320(pdgfrb)
XMA: 102229755 102233464(pdgfrb)
XCO: 114139478(pdgfrb) 114153115
XHE: 116713960(pdgfrb) 116728444
PRET: 103459902 103471279(pdgfrb)
PLAI: 106939821 106948556(pdgfrb)
PMEI: 106907217(pdgfrb) 106918551
GAF: 122837604(pdgfrb) 122844817
CVG: 107095000(pdgfrb) 107102292
CTUL: 119777911(pdgfrb) 119785587
GMU: 124860432(pdgfrb) 124876578
NFU: 107375657(pdgfrb)
KMR: 108228837 108240544(pdgfrb)
ALIM: 106517359(pdgfrb) 106532997
NWH: 119408779(pdgfrb)
AOCE: 111569523(pdgfrb) 111575719
CSEM: 103391002(pdgfrb) 103392104
POV: 109626437(pdgfrb)
SSEN: 122762812 122778422(pdgfrb)
HHIP: 117769118(pdgfrb)
LCF: 108873646 108899186(pdgfrb)
SDU: 111226471(pdgfrb) 111239485
SLAL: 111646633(pdgfrb) 111671142
XGL: 120785203(pdgfrb) 120802843
HCQ: 109518748(pdgfrb) 109528881
SFM: 108936824(pdgfrb)
PKI: 111855164(pdgfrb)
AANG: 118223372(pdgfrb) 118234934
LOC: 102697036(pdgfrb)
PSPA: 121297330(pdgfrb) 121324756
ARUT: 117413283(pdgfrb)
LCM: 102361386(PDGFRB)
CMK: 103188232
ATEN: 116297063
 » show all
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]
LinkDB

KEGG   ORTHOLOGY: K04362
Entry
K04362                      KO                                     
Symbol
FGFR1, CD331
Name
fibroblast growth factor receptor 1 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04520  Adherens junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04714  Thermogenesis
map04810  Regulation of actin cytoskeleton
map04928  Parathyroid hormone synthesis, secretion and action
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05215  Prostate cancer
map05218  Melanoma
map05224  Breast cancer
map05230  Central carbon metabolism in cancer
Disease
H00031  Breast cancer
H00255  Hypogonadotropic hypogonadism
H00443  Osteoglophonic dysplasia
H00458  Syndromic craniosynostoses
H01207  Trigonocephaly
H01756  Pfeiffer syndrome
H01850  Hartsfield syndrome
H01988  Jackson-Weiss syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04014 Ras signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04015 Rap1 signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04020 Calcium signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04151 PI3K-Akt signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05205 Proteoglycans in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05230 Central carbon metabolism in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09162 Cancer: specific types
   05218 Melanoma
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05215 Prostate cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05224 Breast cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   00536 Glycosaminoglycan binding proteins
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
CD molecules [BR:ko04090]
 Proteins
  K04362  CD331, FGFR1; fibroblast growth factor receptor 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Other DBs
GO: 0005007
Genes
HSA: 2260(FGFR1)
PTR: 464122(FGFR1)
PPS: 100988115(FGFR1)
GGO: 101152179(FGFR1)
PON: 100174545(FGFR1)
NLE: 100602423(FGFR1)
MCC: 700126(FGFR1)
MCF: 102144714(FGFR1)
CSAB: 103215648(FGFR1)
CATY: 105590801(FGFR1)
PANU: 101002603(FGFR1)
TGE: 112629744(FGFR1)
RRO: 104679640(FGFR1)
RBB: 108512401(FGFR1)
TFN: 117094867(FGFR1)
PTEH: 111544121(FGFR1)
CJC: 100390192(FGFR1)
SBQ: 101033213(FGFR1)
CSYR: 103274944(FGFR1)
MMUR: 105870403(FGFR1)
OGA: 100960708(FGFR1)
MMU: 14182(Fgfr1)
MCAL: 110299550(Fgfr1)
MPAH: 110336809(Fgfr1)
RNO: 79114(Fgfr1)
MCOC: 116069056(Fgfr1)
MUN: 110563307(Fgfr1)
CGE: 100773586(Fgfr1)
PLEU: 114681341(Fgfr1)
NGI: 103745770(Fgfr1)
HGL: 101700324(Fgfr1)
CPOC: 100731156(Fgfr1)
CCAN: 109688936(Fgfr1)
DORD: 105992799(Fgfr1)
DSP: 122107616(Fgfr1)
OCU: 100351861(FGFR1)
OPI: 101534918(FGFR1)
TUP: 102484087(FGFR1)
CFA: 100856477(FGFR1)
VVP: 112916136(FGFR1)
VLG: 121489119(FGFR1)
AML: 100472630(FGFR1)
UMR: 103659146(FGFR1)
UAH: 113262086(FGFR1)
UAR: 123780346(FGFR1)
ELK: 111144420
LLV: 125092758
MPUF: 101691149(FGFR1)
ORO: 101364849(FGFR1)
EJU: 114224838(FGFR1)
ZCA: 113924319(FGFR1)
MLX: 118009956(FGFR1)
FCA: 101086055(FGFR1)
PYU: 121017369(FGFR1)
PBG: 122473425(FGFR1)
PTG: 102972346(FGFR1)
PPAD: 109262303(FGFR1)
AJU: 106978376(FGFR1)
HHV: 120238662(FGFR1)
BTA: 281768(FGFR1)
BOM: 102267776(FGFR1)
BIU: 109553304(FGFR1)
BBUB: 102407288(FGFR1)
CHX: 102180282(FGFR1)
OAS: 780507(FGFR1)
ODA: 120865665(FGFR1)
CCAD: 122432228(FGFR1)
SSC: 100153248(FGFR1)
CFR: 102515264(FGFR1)
CBAI: 105071441(FGFR1)
CDK: 105105270(FGFR1)
VPC: 102531272(FGFR1)
BACU: 103017733(FGFR1)
LVE: 103069902(FGFR1)
OOR: 101279623(FGFR1)
DLE: 111173523(FGFR1)
PCAD: 102989551(FGFR1)
PSIU: 116746732(FGFR1)
ECB: 100057614(FGFR1)
EPZ: 103560266(FGFR1)
EAI: 106824659(FGFR1)
MYB: 102253832(FGFR1)
MYD: 102759202(FGFR1)
MMYO: 118649562(FGFR1)
MLF: 102423450(FGFR1)
MNA: 107535065(FGFR1)
PKL: 118728579(FGFR1)
HAI: 109373149(FGFR1)
DRO: 112306733(FGFR1)
SHON: 118993177(FGFR1)
AJM: 119065040(FGFR1)
PDIC: 114508370(FGFR1)
PHAS: 123807471(FGFR1)
MMF: 118622697(FGFR1)
RFQ: 117021283(FGFR1)
PALE: 102898943(FGFR1)
PGIG: 120595650(FGFR1)
PVP: 105300315(FGFR1)
RAY: 107515961(FGFR1)
MJV: 108403050(FGFR1)
TOD: 119257820(FGFR1)
SARA: 101544250(FGFR1)
LAV: 100662289(FGFR1)
TMU: 101342270
DNM: 101427669(FGFR1)
MDO: 100029852(FGFR1)
GAS: 123236988(FGFR1)
SHR: 100914347(FGFR1)
PCW: 110207578(FGFR1)
OAA: 100074240(FGFR1)
GGA: 396516(FGFR1)
PCOC: 116234528(FGFR1)
MGP: 100547498(FGFR1)
CJO: 107323773(FGFR1)
NMEL: 110387131(FGFR1)
ACYG: 106044374(FGFR1)
AFUL: 116499369(FGFR1)
TGU: 100221243(FGFR1)
LSR: 110473397(FGFR1)
SCAN: 103822693(FGFR1)
PMOA: 120505592(FGFR1)
OTC: 121346743(FGFR1)
PRUF: 121359634(FGFR1)
GFR: 102033908(FGFR1)
FAB: 101822220(FGFR1)
PHI: 102103637(FGFR1)
PMAJ: 107213845(FGFR1)
CCAE: 111938850(FGFR1)
CCW: 104694904(FGFR1)
ETL: 114066493(FGFR1)
FPG: 101914093(FGFR1)
FCH: 102055369(FGFR1)
CLV: 102085235(FGFR1)
EGZ: 104135322(FGFR1)
NNI: 104016019(FGFR1)
TALA: 116962981(FGFR1)
PADL: 103912362(FGFR1)
ACHC: 115350076(FGFR1)
AAM: 106492992(FGFR1)
AROW: 112965467(FGFR1)
NPD: 112952906(FGFR1)
DNE: 112991606(FGFR1)
ASN: 102386174(FGFR1)
AMJ: 102574117(FGFR1)
CPOO: 109317416(FGFR1)
GGN: 109295541(FGFR1)
PSS: 102461506(FGFR1)
CMY: 102942878(FGFR1)
CPIC: 101941076(FGFR1)
TST: 117873025(FGFR1)
CABI: 116821412(FGFR1)
MRV: 120397459(FGFR1)
ACS: 100559018(fgfr1)
PVT: 110072166(FGFR1)
SUND: 121935105(FGFR1)
PBI: 103066603(FGFR1)
PMUR: 107289991(FGFR1)
TSR: 106545617(FGFR1)
PGUT: 117674750(FGFR1)
VKO: 123026996(FGFR1)
PMUA: 114585343(FGFR1)
ZVI: 118097182(FGFR1)
GJA: 107113006(FGFR1)
XLA: 397782(xfgfra2) 399444(fgfr1.L)
XTR: 548648(fgfr1)
NPR: 108791453(FGFR1)
RTEM: 120933172(FGFR1)
BBUF: 120986282(FGFR1)
BGAR: 122927312(FGFR1)
DRE: 30705(fgfr1a) 567905(fgfr1b) 569566
IPU: 108265400
SMEO: 124399782(fgfr1a)
EEE: 113588173
TRU: 101073964 101078564(fgfr1)
CGOB: 115013012
ELY: 117252130(fgfr1a) 117269626
PLEP: 121944930(fgfr1a) 121960119
ECRA: 117944490(fgfr1a)
PFLV: 114555046(fgfr1) 114571184
GAT: 120830735(fgfr1a) 120831703(fgfr1b)
PPUG: 119225164(fgfr1a) 119226955(fgfr1b)
MSAM: 119891967(fgfr1a) 119914512
CUD: 121509445(fgfr1a) 121524792
OLA: 100125448(fgfr1) 101155126
OML: 112148278(fgfr1a) 112162937
XCO: 114149547 114154182(fgfr1)
XHE: 116724736 116729276(fgfr1)
GAF: 122819204(fgfr1b) 122828077(fgfr1a)
CVG: 107081801
CTUL: 119790883(fgfr1a)
GMU: 124877368(fgfr1a)
KMR: 108231094(fgfr1b) 108239355(si:ch211-167j9.5) 108247308(fgfr1a)
NWH: 119414055(fgfr1a) 119424280
AOCE: 111571065
SSEN: 122764198 122770547(fgfr1a)
HHIP: 117767647(fgfr1a) 117771314(fgfr1b)
XGL: 120805029(fgfr1a) 120806286(fgfr1b)
MALB: 109954836
OTW: 112220247 112230834(fgfr1b) 112248453 112262942(fgfr1a)
OGO: 124007249(fgfr1b) 124034343 124036276(fgfr1a) 124049109
SNH: 120021867(fgfr1b) 120025797 120063215(fgfr1a) 120066669
AANG: 118206299(fgfr1a) 118212554(fgfr1b)
LOC: 102691524(fgfr1)
LCM: 102361014(FGFR1)
CMK: 103190693
CIN: 101242971 445706(fgfr)
SPU: 373310(FGFR)
DME: Dmel_CG10244(Cad96Ca)
DER: 6555476
DSE: 6619674
DSI: Dsimw501_GD18227(Dsim_GD18227)
DAN: 6499881
DSR: 110189031
DPE: 6591372
DMN: 108156267
DWI: 6651312
DGR: 6564406
DAZ: 108621257
DNV: 108650218
DHE: 111601307
DVI: 6629492
CCAT: 101456091
BOD: 106624537
MDE: 101899591
SCAC: 106088359
LCQ: 111681381
ACOZ: 120958029
AARA: 120902795
AAG: 5566872
CPII: 120421866
CNS: 116347608
AME: 409061
ACER: 107998567
ALAB: 122710542
BIM: 100741569
BBIF: 117206459
BVK: 117237037
BVAN: 117160544
BTER: 100645261
BPYO: 122569761
CCAL: 108630549
OBB: 114878584
MGEN: 117218328
CGIG: 122397218
SOC: 105196016
MPHA: 105830817
AEC: 105151199
ACEP: 105624990
DQU: 106748875
FEX: 115233632
LHU: 105675703
PGC: 109853575
OBO: 105287184
PCF: 106787566
PFUC: 122524166
VPS: 122634159
CSOL: 105368181
TPRE: 106651808
MDL: 103574949
DAM: 107038713
AGIF: 122859164
TCA: 659961(Cad96Ca)
DPA: 109536590
SOY: 115881324
ATD: 109595758
CSET: 123319293
LDC: 111502871
NVL: 108565944
APLN: 108734977
PPYR: 116164364
OTU: 111428324
BMOR: 101745512
BMAN: 114253316
BANY: 112050625
PMAC: 106720097
PPOT: 106108357
PXU: 106121251
PRAP: 111004172
ZCE: 119840556
HAW: 110379194
TNL: 113500453
OFU: 114364010
PXY: 105387388
DNX: 107166442
AGS: 114124499
RMD: 113556718
BTAB: 109043826
DCI: 113468778
CLEC: 106674164
NLU: 111046370
FOC: 113213432
ZNE: 110836649
CSEC: 111870191
PVM: 113825602
PJA: 122260055
HAME: 121873128
PCLA: 123769196
PTRU: 123507697
HAZT: 108671962
VDE: 111255383
VJA: 111261194
TUT: 107365937
DPTE: 113790798
CSCU: 111629419
PTEP: 107441235
TSP: Tsp_00617
MYI: 110459294
OSN: 115212177
EGL: EGR_04208
AQU: 100632318
 » show all
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
DOI:10.1002/j.1460-2075.1990.tb07454.x
  Sequence
[hsa:2260]
LinkDB

KEGG   ORTHOLOGY: K05093
Entry
K05093                      KO                                     
Symbol
FGFR2, CD332
Name
fibroblast growth factor receptor 2 [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04550  Signaling pathways regulating pluripotency of stem cells
map04810  Regulation of actin cytoskeleton
map05200  Pathways in cancer
map05215  Prostate cancer
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00458  Syndromic craniosynostoses
H00642  Lacrimo-auriculo-dento-digital syndrome
H01753  Antley-Bixler syndrome
H01754  Crouzon syndrome
H01755  Apert syndrome
H01756  Pfeiffer syndrome
H01988  Jackson-Weiss syndrome
H01989  Beare-Stevenson syndrome
H01991  Saethre-Chotzen syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04014 Ras signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04015 Rap1 signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04020 Calcium signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   04151 PI3K-Akt signaling pathway
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05230 Central carbon metabolism in cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09162 Cancer: specific types
   05226 Gastric cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   05215 Prostate cancer
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
   00536 Glycosaminoglycan binding proteins
    K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
CD molecules [BR:ko04090]
 Proteins
  K05093  CD332, FGFR2; fibroblast growth factor receptor 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K05093  FGFR2, CD332; fibroblast growth factor receptor 2
Other DBs
GO: 0005007
Genes
HSA: 2263(FGFR2)
PTR: 466220(FGFR2)
PPS: 100981139(FGFR2)
GGO: 101153046(FGFR2)
PON: 100171540(FGFR2)
NLE: 100598157(FGFR2)
MCC: 715949(FGFR2)
MCF: 102143086(FGFR2)
CSAB: 103216628(FGFR2)
CATY: 105577985(FGFR2)
PANU: 101002495(FGFR2)
TGE: 112631500(FGFR2)
RRO: 104675847(FGFR2)
RBB: 108529768(FGFR2)
TFN: 117065679(FGFR2)
PTEH: 111550787(FGFR2)
CJC: 100393573(FGFR2)
SBQ: 101033845(FGFR2)
CSYR: 103250719(FGFR2)
MMUR: 105870804(FGFR2)
OGA: 100952813(FGFR2)
MMU: 14183(Fgfr2)
MCAL: 110299396(Fgfr2)
MPAH: 110326449(Fgfr2)
RNO: 25022(Fgfr2)
MCOC: 116103077(Fgfr2)
MUN: 110554946(Fgfr2)
CGE: 100763455(Fgfr2)
PLEU: 114692385(Fgfr2)
NGI: 103729272(Fgfr2)
HGL: 101709077(Fgfr2)
CPOC: 100379152(Fgfr2)
CCAN: 109691649(Fgfr2)
DORD: 105989771(Fgfr2)
DSP: 122126852(Fgfr2)
OCU: 100009417(FGFR2)
OPI: 101531872(FGFR2)
TUP: 102484403(FGFR2)
CFA: 415125(FGFR2)
VVP: 112916723(FGFR2)
VLG: 121484320(FGFR2)
AML: 100468267(FGFR2)
UMR: 103657802(FGFR2)
UAH: 113252011(FGFR2)
UAR: 123796025(FGFR2)
LLV: 125084713
MPUF: 101683248(FGFR2)
ORO: 101381278(FGFR2)
EJU: 114223046(FGFR2)
ZCA: 113922030(FGFR2)
MLX: 118027178(FGFR2)
FCA: 101095198(FGFR2)
PYU: 121037313(FGFR2)
PBG: 122493321(FGFR2)
PTG: 102964142(FGFR2)
PPAD: 109272992(FGFR2)
AJU: 106969379(FGFR2)
HHV: 120244115(FGFR2)
BTA: 404193(FGFR2)
BOM: 102270743(FGFR2)
BIU: 109553142(FGFR2)
BBUB: 102402932(FGFR2)
CHX: 102170938(FGFR2)
OAS: 443548(FGFR2)
ODA: 120873875(FGFR2)
CCAD: 122445860(FGFR2)
SSC: 396762(FGFR2)
CFR: 102516073(FGFR2)
CBAI: 105080789(FGFR2)
CDK: 105104060(FGFR2)
VPC: 102535372(FGFR2)
BACU: 103012184(FGFR2)
LVE: 103090812(FGFR2)
OOR: 101272068(FGFR2)
DLE: 111172240(FGFR2)
PCAD: 102982044(FGFR2)
PSIU: 116741579(FGFR2)
ECB: 100033956(FGFR2)
EPZ: 103547114(FGFR2)
EAI: 106846935(FGFR2)
MYB: 102254053(FGFR2)
MYD: 102763283(FGFR2)
MMYO: 118655613(FGFR2)
MNA: 107532684(FGFR2)
PKL: 118710524(FGFR2)
HAI: 109383003(FGFR2)
DRO: 112300272(FGFR2)
SHON: 118996291(FGFR2)
AJM: 119063507(FGFR2)
PDIC: 114496712(FGFR2)
PHAS: 123828714(FGFR2)
MMF: 118632260(FGFR2)
RFQ: 117035827(FGFR2)
PALE: 102882899(FGFR2)
PGIG: 120608860(FGFR2)
PVP: 105291441(FGFR2)
RAY: 107512997(FGFR2)
MJV: 108395520(FGFR2)
TOD: 119234070(FGFR2)
SARA: 101555338(FGFR2)
LAV: 100664128
TMU: 101357035
DNM: 101412269(FGFR2)
MDO: 100025727(FGFR2)
GAS: 123234272(FGFR2)
SHR: 100932215(FGFR2)
PCW: 110209582(FGFR2)
OAA: 100084641(FGFR2)
GGA: 396259(FGFR2)
PCOC: 116231564(FGFR2)
MGP: 100540905(FGFR2)
CJO: 107316195(FGFR2)
NMEL: 110399304(FGFR2)
APLA: 101791540(FGFR2)
ACYG: 106038987(FGFR2)
AFUL: 116491246(FGFR2)
TGU: 100223379(FGFR2)
LSR: 110469999(FGFR2)
SCAN: 103813785(FGFR2)
PMOA: 120502097(FGFR2)
OTC: 121341866(FGFR2)
PRUF: 121350260(FGFR2)
GFR: 102038840(FGFR2)
FAB: 101812169(FGFR2)
PHI: 102105117(FGFR2)
PMAJ: 107206911(FGFR2)
CCAE: 111931374(FGFR2)
CCW: 104694675(FGFR2)
ETL: 114065192(FGFR2)
ZAB: 102066026(FGFR2)
FPG: 101913692(FGFR2)
FCH: 102056102(FGFR2)
CLV: 102091137(FGFR2)
EGZ: 104123669(FGFR2)
NNI: 104020574(FGFR2)
ACUN: 113481500(FGFR2)
TALA: 104360381(FGFR2)
PADL: 103918542(FGFR2)
ACHC: 115348147(FGFR2)
AAM: 106499024(FGFR2)
AROW: 112965209(FGFR2)
NPD: 112957077(FGFR2)
DNE: 112986315(FGFR2)
ASN: 102382394(FGFR2)
AMJ: 102564591(FGFR2)
CPOO: 109323987(FGFR2)
GGN: 109287672(FGFR2) 109293177
PSS: 102443772(FGFR2)
CMY: 102938554(FGFR2)
CPIC: 101933273(FGFR2)
TST: 117879776(FGFR2)
CABI: 116822675(FGFR2)
MRV: 120368575(FGFR2)
ACS: 100562611(fgfr2)
PVT: 110075320(FGFR2)
SUND: 121925296(FGFR2)
PBI: 103057830(FGFR2)
PMUR: 107288600(FGFR2)
TSR: 106554429
PGUT: 117676685(FGFR2)
VKO: 123028381(FGFR2)
PMUA: 114597424(FGFR2)
ZVI: 118096357(FGFR2)
GJA: 107112647(FGFR2)
XLA: 108697372(fgfr2.S) 399325(fgfr2.L)
XTR: 100124910(fgfr2)
NPR: 108793050(FGFR2)
RTEM: 120947029(FGFR2)
BBUF: 121005346(FGFR2)
BGAR: 122941585(FGFR2)
DRE: 352940(fgfr2)
SANH: 107655670 107679170(fgfr2)
SGH: 107585454 107597642(fgfr2)
CCAR: 109068396 109100701(fgfr2)
IPU: 108263349(fgfr2) 108276549
PHYP: 113542009(fgfr2)
SMEO: 124393503 124395584(fgfr2)
AMEX: 103024961
EEE: 113588015(fgfr2)
TRU: 101073665(fgfr2) 105418712
LCO: 104925607(fgfr2)
NCC: 104962476
ELY: 117248769(fgfr2)
PLEP: 121954195(fgfr2)
SLUC: 116039340(fgfr2) 116040274(si:ch211-167j9.5)
ECRA: 117942512(si:ch211-167j9.5) 117960195(fgfr2)
PFLV: 114552491 114571757(fgfr2)
GAT: 120817859(si:ch211-167j9.5) 120820493(fgfr2)
PPUG: 119213806(fgfr2) 119217446(tmem97)
MSAM: 119916902(fgfr2)
CUD: 121510643(fgfr2) 121517567(si:ch211-167j9.5)
MZE: 101463957(fgfr2)
ONL: 100699731(fgfr2)
OAU: 116311454(si:ch211-167j9.5) 116318595(fgfr2)
OLA: 100049483(fgfr2) 101174210
OML: 112136376(si:ch211-167j9.5) 112161613(fgfr2)
XMA: 102233809
XCO: 114138295
PRET: 103477293
PFOR: 103137630
PMEI: 106903797
GAF: 122833118(si:ch211-167j9.5) 122842287(fgfr2)
CVG: 107081753(fgfr2)
CTUL: 119789685(fgfr2) 119796193(si:ch211-167j9.5)
GMU: 124859662(fgfr2) 124883651(si:ch211-167j9.5)
NFU: 107375397(fgfr2)
KMR: 108240654(fgfr2)
ALIM: 106526530(fgfr2)
NWH: 119411078(fgfr2)
AOCE: 111571792(fgfr2)
CSEM: 103391367
SSEN: 122773086(si:ch211-167j9.5) 122781540(fgfr2)
HHIP: 117773414(si:ch211-167j9.5) 117775137(fgfr2)
LCF: 108885762(fgfr2) 108900295
SDU: 111220545(fgfr2)
SLAL: 111658940(fgfr2)
XGL: 120796261(fgfr2)
HCQ: 109523130(fgfr2)
BPEC: 110168143(fgfr2)
MALB: 109959332(fgfr2)
OGO: 124041500(fgfr2) 124048540
ELS: 105010630(fgfr2)
SFM: 108925828(fgfr2)
PKI: 111839944(fgfr2)
AANG: 118217986(fgfr2)
LOC: 102694148(fgfr2)
PSPA: 121321987 121326089(fgfr2)
ARUT: 117418264(fgfr2)
LCM: 102349925(FGFR2)
CMK: 103185425
RTP: 109910693(fgfr2)
BBEL: 109485268
SPU: 115917872
DME: Dmel_CG32134(btl)
DER: 6545596
DSE: 6605643
DSI: Dsimw501_GD14480(Dsim_GD14480)
DSR: 110190281
DPE: 113565986
DMN: 108152297
DWI: 6639356
DAZ: 108612213
DNV: 108651226
DHE: 111600927
CCAT: 101451533
BOD: 106620806
MDE: 101901067
SCAC: 106094085
LCQ: 111675215
ACOZ: 120949783
AARA: 120894545
AME: 413200
ACER: 108000765
ALAB: 122713830
BIM: 100747636
BBIF: 117205543
BVK: 117230758
BVAN: 117157337
BTER: 100643345
BPYO: 122575688
CCAL: 108632478
OBB: 114878227
MGEN: 117229741
NMEA: 116431623
CGIG: 122394896
SOC: 105196299
MPHA: 105830905
AEC: 105147047
ACEP: 105624923
VEM: 105565532
DQU: 106748031
CFO: 105249959
LHU: 105679827
OBO: 105278054
PCF: 106786979
PFUC: 122515288
VPS: 122635900
MDL: 103569982
CGLO: 123271300
CCIN: 107271667
TCA: 659434(DFR1)
NVL: 108565311
BANY: 112046739
OFU: 114361867
RMD: 113554812
BTAB: 109038511
DCI: 103524925
CLEC: 106661466
NLU: 111062599
ZNE: 110826648
FCD: 110841674
DSV: 119459281
RSAN: 119379191
RMP: 119175876
VDE: 111250724
VJA: 111266775
TUT: 107364957
DPTE: 113797385
PTEP: 107438841
GAE: 121383252
MYI: 110455387
MMER: 123529063
OBI: 106868677
LAK: 106166604
DGT: 114526313
AQU: 100633582
 » show all
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
DOI:10.1002/j.1460-2075.1990.tb07454.x
  Sequence
[hsa:2263]
LinkDB

KEGG   ORTHOLOGY: K05094
Entry
K05094                      KO                                     
Symbol
FGFR3, CD333
Name
fibroblast growth factor receptor 3 [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04550  Signaling pathways regulating pluripotency of stem cells
map04810  Regulation of actin cytoskeleton
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05219  Bladder cancer
map05230  Central carbon metabolism in cancer
Disease
H00010  Multiple myeloma
H00022  Bladder cancer
H00023  Testicular cancer
H00458  Syndromic craniosynostoses
H00505  FGFR3-related short limb skeletal dysplasia
H00642  Lacrimo-auriculo-dento-digital syndrome
H00997  CATSHL syndrome
H01749  Achondroplasia
H01750  Thanatophoric dysplasia
H01754  Crouzon syndrome
H01990  Muenke syndrome
H02068  Hypochondroplasia
H02069  SADDAN
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04014 Ras signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04015 Rap1 signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04020 Calcium signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04151 PI3K-Akt signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   05206 MicroRNAs in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   05230 Central carbon metabolism in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09162 Cancer: specific types
   05219 Bladder cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05094  FGFR3, CD333; fibroblast growth factor receptor 3
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05094  FGFR3, CD333; fibroblast growth factor receptor 3
CD molecules [BR:ko04090]
 Proteins
  K05094  CD333, FGFR3; fibroblast growth factor receptor 3
Other DBs
GO: 0005007
Genes
HSA: 2261(FGFR3)
PTR: 461067(FGFR3)
PPS: 100976551(FGFR3)
GGO: 101139997(FGFR3) 115932714 115932715
PON: 100433126(FGFR3)
NLE: 100591839(FGFR3)
MCC: 712829(FGFR3)
MCF: 102128947(FGFR3)
CSAB: 103246479(FGFR3)
CATY: 105585485(FGFR3)
PANU: 101014560(FGFR3)
TGE: 112625207(FGFR3)
RRO: 104678934(FGFR3)
RBB: 108532286(FGFR3)
TFN: 117085041(FGFR3)
PTEH: 111539069(FGFR3)
CJC: 100409938(FGFR3)
SBQ: 101051421(FGFR3)
CSYR: 103272218(FGFR3)
MMUR: 105856032(FGFR3)
OGA: 100962219(FGFR3)
MMU: 14184(Fgfr3)
MCAL: 110293909(Fgfr3)
MPAH: 110330788(Fgfr3)
RNO: 84489(Fgfr3)
MCOC: 116069961(Fgfr3)
MUN: 110557305(Fgfr3)
CGE: 100764560(Fgfr3)
PLEU: 114694056(Fgfr3)
NGI: 103741127(Fgfr3)
HGL: 101711651(Fgfr3)
CPOC: 100732948(Fgfr3)
CCAN: 109695016(Fgfr3)
DORD: 105991261(Fgfr3)
DSP: 122100692(Fgfr3)
OPI: 101521291(FGFR3)
TUP: 102500041(FGFR3)
CFA: 488808(FGFR3)
VVP: 112922612(FGFR3)
VLG: 121489705(FGFR3)
AML: 100481826(FGFR3)
UAH: 113245744(FGFR3)
UAR: 123777846(FGFR3)
ELK: 111149137
LLV: 125093458
MPUF: 101691659(FGFR3)
ORO: 101381434(FGFR3)
EJU: 114196996(FGFR3)
ZCA: 113925082(FGFR3)
MLX: 118010795(FGFR3)
FCA: 100141386(FGFR3)
PYU: 121039432(FGFR3)
PBG: 122479132(FGFR3)
PPAD: 109269781(FGFR3)
AJU: 106978850(FGFR3)
HHV: 120231844(FGFR3)
BTA: 281769(FGFR3)
BOM: 102264670(FGFR3)
BIU: 109560724(FGFR3)
BBUB: 102395462(FGFR3)
OAS: 554324(FGFR3)
ODA: 120861835(FGFR3)
CCAD: 122428025(FGFR3) 122442295
SSC: 100514115(FGFR3)
CFR: 102512878(FGFR3)
CBAI: 105072182(FGFR3)
CDK: 105100875(FGFR3)
VPC: 102531487(FGFR3)
BACU: 103002473(FGFR3)
LVE: 103086424(FGFR3)
OOR: 101273169(FGFR3)
DLE: 111164861(FGFR3)
PCAD: 102982240(FGFR3)
PSIU: 116754486(FGFR3)
ECB: 100034114(FGFR3)
EPZ: 103556997(FGFR3)
EAI: 106830606(FGFR3)
MMYO: 118665364(FGFR3)
MNA: 107524118(FGFR3)
PKL: 118707163(FGFR3)
HAI: 109390958(FGFR3)
SHON: 118987768(FGFR3)
AJM: 119035526(FGFR3)
PDIC: 114489924(FGFR3)
PHAS: 123815667(FGFR3)
MMF: 118633856(FGFR3)
RFQ: 117022243(FGFR3)
PALE: 102878342(FGFR3)
PGIG: 120582906(FGFR3)
PVP: 105301871(FGFR3)
RAY: 107518024(FGFR3)
MJV: 108383914(FGFR3)
TOD: 119260900(FGFR3)
SARA: 101551516(FGFR3)
LAV: 100674054(FGFR3)
TMU: 101341002
DNM: 101428113(FGFR3)
MDO: 100023287(FGFR3)
GAS: 123252878(FGFR3)
SHR: 100913979(FGFR3)
PCW: 110212245(FGFR3)
OAA: 100084071(FGFR3)
GGA: 396515(FGFR3)
PCOC: 116225737(FGFR3)
MGP: 100543461(FGFR3)
CJO: 107313983(FGFR3)
NMEL: 110398027(FGFR3)
APLA: 101804995(FGFR3)
ACYG: 106034332(FGFR3)
AFUL: 116488690(FGFR3)
TGU: 100218924(FGFR3)
LSR: 110473290(FGFR3)
SCAN: 103826117(FGFR3)
PMOA: 120509387(FGFR3)
OTC: 121334977(FGFR3)
PRUF: 121348993(FGFR3)
GFR: 102044988(FGFR3)
FAB: 101812160(FGFR3)
PHI: 102114034(FGFR3)
PMAJ: 107203422(FGFR3)
CCAE: 111927721(FGFR3)
CCW: 104690922(FGFR3)
ETL: 114061475(FGFR3)
ZAB: 102063305(FGFR3)
FPG: 101920747(FGFR3)
FCH: 102052231(FGFR3)
CLV: 102098275(FGFR3)
EGZ: 104130196(FGFR3)
NNI: 104018093(FGFR3)
TALA: 104357159(FGFR3)
PADL: 103920985(FGFR3)
ACHC: 115343423(FGFR3)
AAM: 106498761(FGFR3)
AROW: 112965516(FGFR3)
NPD: 112942995(FGFR3)
DNE: 112990762(FGFR3)
ASN: 102371740(FGFR3)
AMJ: 106736800(FGFR3)
CPOO: 109322182(FGFR3)
GGN: 109303914(FGFR3)
PSS: 102444715(FGFR3)
CMY: 102939991(FGFR3)
CPIC: 101933794(FGFR3)
TST: 117878458(FGFR3)
CABI: 116817612(FGFR3) 116826290
PVT: 110085587(FGFR3)
SUND: 121925139(FGFR3)
PBI: 103067086(FGFR3)
TSR: 106555648
PGUT: 117664767(FGFR3)
VKO: 123032384(FGFR3)
PMUA: 114596954(FGFR3)
ZVI: 118078263 118096480(FGFR3)
XLA: 399347(fgfr3.S) 779370(fgfr3.L)
XTR: 100196923(fgfr3)
NPR: 108788840(FGFR3)
RTEM: 120924362(FGFR3)
BBUF: 120990414(FGFR3)
BGAR: 122939392(FGFR3)
DRE: 58129(fgfr3)
CCAR: 109098492
IPU: 108263592(fgfr3)
PHYP: 113539741(fgfr3)
SMEO: 124398345(fgfr3)
AMEX: 103045058(fgfr3)
EEE: 113589671(fgfr3)
TRU: 101063860(fgfr3)
LCO: 104926793(fgfr3)
NCC: 104955633
CGOB: 115027139
ELY: 117267283(fgfr3)
PLEP: 121953470(fgfr3)
SLUC: 116036735(fgfr3)
ECRA: 117935936(fgfr3)
PFLV: 114546647
GAT: 120833006(fgfr3)
PPUG: 119227613(fgfr3)
MSAM: 119910102(fgfr3)
CUD: 121526058(fgfr3)
MZE: 101476450(fgfr3)
ONL: 100689850(fgfr3)
OAU: 116329031(fgfr3)
OLA: 100049424(fgfr3)
OML: 112139739(fgfr3)
XMA: 102228238
XCO: 114134047(fgfr3)
XHE: 116708872(fgfr3)
PRET: 103458160
PFOR: 103149422(fgfr3)
PLAI: 106952470(fgfr3)
PMEI: 106922536(fgfr3)
GAF: 122846087(fgfr3)
CVG: 107087110
CTUL: 119796224(fgfr3)
GMU: 124855142(fgfr3)
NFU: 107391665
ALIM: 106519945(fgfr3)
NWH: 119426968(fgfr3)
AOCE: 111580110(fgfr3)
CSEM: 103383204(fgfr3)
SSEN: 122782744(fgfr3)
HHIP: 117755965(fgfr3)
LCF: 108889150(fgfr3)
SDU: 111226196(fgfr3)
SLAL: 111646819(fgfr3)
XGL: 120795599(fgfr3)
HCQ: 109520993(fgfr3)
BPEC: 110155643(fgfr3)
MALB: 109962419(fgfr3)
OTW: 112241224(fgfr3)
OMY: 110519382(fgfr3)
OGO: 124046839(fgfr3)
ELS: 105015916(fgfr3)
SFM: 108920925(fgfr3)
PKI: 111844207(fgfr3)
AANG: 118227480(fgfr3)
LOC: 102691474(fgfr3)
LCM: 102364583(FGFR3)
CMK: 103181516(fgfr3)
DME: Dmel_CG7223(htl)
DER: 6552001
DGR: 6568139
FEX: 115239000
PFUC: 122514693
VPS: 122632988
TPRE: 106660396
FAS: 105264710
DAM: 107045702
CSET: 123321607
LDC: 111506930
APLN: 108740541
PPYR: 116165339
OTU: 111425220
MSEX: 115446494
PPOT: 106102608
PXU: 106114513
FOC: 113215199
CSEC: 111872649
DMK: 116918797
PJA: 122254600
HAME: 121877401
PCLA: 123760066
PTRU: 123510787
HAZT: 108678442
BGT: 106071935
GAE: 121383688
HRF: 124139370
CRG: 105325059
PMAX: 117339943
HMG: 100206525(FGFR) 100214111
 » show all
Reference
  Authors
Terada M, Shimizu A, Sato N, Miyakaze SI, Katayama H, Kurokawa-Seo M
  Title
Fibroblast growth factor receptor 3 lacking the Ig IIIb and transmembrane domains secreted from human squamous cell carcinoma DJM-1 binds to FGFs.
  Journal
Mol Cell Biol Res Commun 4:365-73 (2001)
DOI:10.1006/mcbr.2001.0306
  Sequence
[hsa:2261]
LinkDB

KEGG   ORTHOLOGY: K05095
Entry
K05095                      KO                                     
Symbol
FGFR4, CD334
Name
fibroblast growth factor receptor 4 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04550  Signaling pathways regulating pluripotency of stem cells
map04810  Regulation of actin cytoskeleton
map05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
   04014 Ras signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
   04015 Rap1 signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
   04020 Calcium signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
   04151 PI3K-Akt signaling pathway
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05095  FGFR4, CD334; fibroblast growth factor receptor 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05095  FGFR4, CD334; fibroblast growth factor receptor 4
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05095  FGFR4, CD334; fibroblast growth factor receptor 4
CD molecules [BR:ko04090]
 Proteins
  K05095  CD334, FGFR4; fibroblast growth factor receptor 4
Other DBs
GO: 0005007
Genes
HSA: 2264(FGFR4)
PTR: 462301(FGFR4)
PPS: 100991315(FGFR4)
GGO: 101145205(FGFR4)
PON: 100461105(FGFR4)
NLE: 100582351(FGFR4)
MCC: 698494(FGFR4)
MCF: 102118990(FGFR4)
CSAB: 103245042(FGFR4)
CATY: 105581716(FGFR4)
PANU: 101025157(FGFR4)
TGE: 112625972(FGFR4)
RRO: 104680447(FGFR4)
RBB: 108544759(FGFR4)
TFN: 117065345(FGFR4)
PTEH: 111521629(FGFR4)
CJC: 100414348(FGFR4)
SBQ: 101027585(FGFR4)
MMUR: 105883822(FGFR4)
OGA: 100957667(FGFR4)
MMU: 14186(Fgfr4)
MCAL: 110307648(Fgfr4)
MPAH: 110333996(Fgfr4)
RNO: 25114(Fgfr4)
MCOC: 116082061(Fgfr4)
MUN: 110549775(Fgfr4)
CGE: 100765320(Fgfr4)
PLEU: 114689359(Fgfr4)
NGI: 103732354(Fgfr4)
HGL: 101700214(Fgfr4)
CPOC: 100733523(Fgfr4)
CCAN: 109685768(Fgfr4)
DORD: 105985440(Fgfr4)
DSP: 122096494(Fgfr4)
OCU: 100355275(FGFR4)
OPI: 101523935(FGFR4)
TUP: 102475159(FGFR4)
CFA: 489095(FGFR4)
VVP: 112925658(FGFR4)
VLG: 121488199(FGFR4)
AML: 100477678(FGFR4)
UMR: 103664454(FGFR4)
UAH: 113264137(FGFR4)
UAR: 123793342(FGFR4)
ELK: 111140867
LLV: 125100667
MPUF: 101692938(FGFR4)
ORO: 101381264(FGFR4)
EJU: 114208656(FGFR4)
ZCA: 113929012(FGFR4)
MLX: 118017149(FGFR4)
FCA: 101100864(FGFR4)
PYU: 121011574(FGFR4)
PBG: 122491274(FGFR4)
PTG: 102965504(FGFR4)
PPAD: 109267570(FGFR4)
AJU: 106975403(FGFR4)
HHV: 120236775(FGFR4)
BTA: 317696(FGFR4)
BOM: 102267813(FGFR4)
BIU: 109561893(FGFR4)
BBUB: 102413025(FGFR4)
CHX: 102183685(FGFR4)
OAS: 101120660(FGFR4)
ODA: 120863866(FGFR4)
CCAD: 122440044(FGFR4)
SSC: 100127133(FGFR4)
CFR: 102510147(FGFR4)
CBAI: 105062044(FGFR4)
CDK: 105099582(FGFR4)
VPC: 102531088(FGFR4)
BACU: 103013305(FGFR4)
LVE: 103078406(FGFR4)
OOR: 101280121(FGFR4)
DLE: 111169850(FGFR4)
PCAD: 114483863(FGFR4)
PSIU: 116751966(FGFR4)
ECB: 100068679(FGFR4)
EPZ: 103557327(FGFR4)
EAI: 106827191(FGFR4)
MYB: 102258015(FGFR4)
MYD: 102759469(FGFR4)
MMYO: 118659099(FGFR4)
MLF: 102419131(FGFR4)
MNA: 107529769(FGFR4)
PKL: 118711485(FGFR4) 118729632
HAI: 109389796(FGFR4)
DRO: 112320339(FGFR4)
SHON: 118999740(FGFR4)
AJM: 119035149(FGFR4)
PDIC: 114509287(FGFR4)
PHAS: 123811430(FGFR4)
MMF: 118643683(FGFR4)
RFQ: 117017069(FGFR4)
PALE: 102879288(FGFR4)
PGIG: 120616553(FGFR4)
PVP: 105293516(FGFR4)
RAY: 107517559(FGFR4)
MJV: 108398432(FGFR4)
TOD: 119236003(FGFR4)
SARA: 101539433(FGFR4)
LAV: 100672193(FGFR4)
TMU: 101344195
DNM: 101426561(FGFR4)
MDO: 100031838(FGFR4)
GAS: 123235492(FGFR4)
SHR: 100919819(FGFR4)
PCW: 110216795(FGFR4)
OAA: 100081967(FGFR4)
GGA: 395603(FGFR4)
PCOC: 116232075(FGFR4)
MGP: 100544316(FGFR4)
CJO: 107320486(FGFR4)
NMEL: 110405535(FGFR4)
APLA: 110354206(FGFR4)
ACYG: 106049509(FGFR4)
AFUL: 116494777(FGFR4)
TGU: 100226243(FGFR4)
LSR: 110470830(FGFR4)
SCAN: 103817508(FGFR4)
PMOA: 120498722(FGFR4)
OTC: 121332220(FGFR4)
PRUF: 121361408(FGFR4)
GFR: 102044508(FGFR4)
FAB: 101814756(FGFR4)
PHI: 102109120(FGFR4)
PMAJ: 107210899(FGFR4)
CCAE: 111943286(FGFR4)
CCW: 104689519(FGFR4)
ETL: 114063827(FGFR4)
ZAB: 102067649(FGFR4)
FPG: 101917722(FGFR4)
FCH: 102055424(FGFR4)
CLV: 102085088(FGFR4)
EGZ: 104128866(FGFR4)
NNI: 104018994(FGFR4)
ACUN: 113485394(FGFR4)
TALA: 104360527(FGFR4)
PADL: 103918814(FGFR4)
ACHC: 115334290(FGFR4)
AAM: 106491594(FGFR4)
AROW: 112964723(FGFR4)
NPD: 112954421(FGFR4)
DNE: 112996921(FGFR4)
ASN: 102368985(FGFR4)
AMJ: 102567148(FGFR4)
CPOO: 109309880(FGFR4)
GGN: 109289746(FGFR4)
CMY: 102930286(FGFR4)
CPIC: 101931613(FGFR4)
CABI: 116828860(FGFR4)
MRV: 120370519(FGFR4)
ACS: 100554153(fgfr4)
PVT: 110077562(FGFR4)
SUND: 121922397(FGFR4)
PBI: 103052689(FGFR4)
PMUR: 107295676(FGFR4)
TSR: 106540885
PGUT: 117680009(FGFR4)
VKO: 123033991(FGFR4)
PMUA: 114591436(FGFR4)
ZVI: 118080501(FGFR4)
GJA: 107111538(FGFR4)
XLA: 397701(fgfr4.L) 398181(fgfr4.S)
XTR: 549077(fgfr4)
NPR: 108783764(FGFR4)
RTEM: 120932197(FGFR4)
BBUF: 120978474(FGFR4)
BGAR: 122926055(FGFR4)
DRE: 100000160(fgfr4)
IPU: 108279190(fgfr4)
PHYP: 113541573(fgfr4)
SMEO: 124398042(fgfr4)
AMEX: 103029904(fgfr4)
EEE: 113571264(fgfr4)
TRU: 101068538
LCO: 104918948(fgfr4)
NCC: 104941715
CGOB: 115018698(fgfr4)
ELY: 117267901(fgfr4)
PLEP: 121952259(fgfr4)
SLUC: 116055969(fgfr4)
ECRA: 117955330(fgfr4)
PFLV: 114566310
GAT: 120822583(fgfr4)
PPUG: 119215360(fgfr4)
MSAM: 119895152(fgfr4)
CUD: 121518895(fgfr4)
MZE: 101477307
ONL: 100692465
OAU: 116319020(fgfr4)
OLA: 100049521
OML: 112142653(fgfr4)
XHE: 116727805
PFOR: 103131912
PLAI: 106964182
PMEI: 106908872
GAF: 122844756(fgfr4)
CVG: 107090685
CTUL: 119786892(fgfr4)
GMU: 124876448(fgfr4)
NFU: 107386693(fgfr4)
KMR: 108238084(fgfr4)
ALIM: 106533801
NWH: 119420428(fgfr4)
AOCE: 111568611
CSEM: 103394934
POV: 109628630(fgfr4)
SSEN: 122779872(fgfr4)
HHIP: 117774371(fgfr4)
LCF: 108893819
SDU: 111234275
SLAL: 111659966(fgfr4)
XGL: 120802475(fgfr4)
HCQ: 109518129
BPEC: 110156464
MALB: 109959288
OTW: 112228540 112257908(fgfr4)
OMY: 110534879 110537527(fgfr4)
ELS: 105011125(fgfr4)
SFM: 108920074(fgfr4)
PKI: 111847950 111860895(fgfr4)
AANG: 118222208 118236410(fgfr4)
LOC: 102687082(fgfr4)
LCM: 102345296(FGFR4)
PRAP: 110999934
DSV: 119452777
HRF: 124121513
HRJ: 124291905
MMER: 123530777
ADF: 107346975
AMIL: 114962175
DGT: 114533984
XEN: 124444766
AQU: 100633399
 » show all
Reference
PMID:1709094
  Authors
Partanen J, Makela TP, Eerola E, Korhonen J, Hirvonen H, Claesson-Welsh L, Alitalo K
  Title
FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
  Journal
EMBO J 10:1347-54 (1991)
DOI:10.1002/j.1460-2075.1991.tb07654.x
  Sequence
[hsa:2264]
LinkDB

KEGG   ORTHOLOGY: K05096
Entry
K05096                      KO                                     
Symbol
FLT1, VEGFR1
Name
FMS-like tyrosine kinase 1 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04066  HIF-1 signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map05202  Transcriptional misregulation in cancer
map05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04014 Ras signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04015 Rap1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04066 HIF-1 signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04020 Calcium signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
   04151 PI3K-Akt signaling pathway
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05096  FLT1, VEGFR1; FMS-like tyrosine kinase 1
Genes
HSA: 2321(FLT1)
PTR: 452512(FLT1)
PPS: 100977352(FLT1)
GGO: 101133492(FLT1)
PON: 100456061(FLT1)
NLE: 100590200(FLT1)
MCC: 574133(FLT1)
MCF: 102115442(FLT1)
CSAB: 103249076(FLT1)
CATY: 105597064(FLT1)
PANU: 101006510(FLT1)
TGE: 112610885(FLT1)
RRO: 104661639(FLT1)
RBB: 108512923(FLT1)
TFN: 117097913(FLT1)
PTEH: 111540453(FLT1)
CJC: 100413680(FLT1)
SBQ: 101053773(FLT1)
CSYR: 103271953
MMUR: 105858897(FLT1)
OGA: 100946241(FLT1)
MMU: 14254(Flt1)
MCAL: 110294038(Flt1)
MPAH: 110339167(Flt1)
RNO: 54251(Flt1)
MCOC: 116068780(Flt1)
CGE: 100761329(Flt1)
PLEU: 114699134(Flt1)
NGI: 103727233(Flt1)
HGL: 101711333(Flt1)
CPOC: 100732326(Flt1)
CCAN: 109694691(Flt1)
DORD: 105993915(Flt1) 105999329
DSP: 122096363 122112548(Flt1)
OCU: 100343352(FLT1) 100358984
OPI: 101519888 101533860(FLT1)
TUP: 102480253(FLT1)
CFA: 403727(FLT1)
VVP: 112918641(FLT1)
VLG: 121496478(FLT1)
AML: 100483462(FLT1)
UMR: 103664410(FLT1)
UAH: 113251212(FLT1)
UAR: 123791948(FLT1)
ELK: 111158583
LLV: 125096245
MPUF: 101689297(FLT1)
ORO: 101383542(FLT1)
EJU: 114211921(FLT1)
ZCA: 113920594(FLT1)
MLX: 118009553(FLT1)
FCA: 101088292(FLT1)
PYU: 121012786(FLT1)
PBG: 122481013(FLT1)
PTG: 102955273(FLT1)
PPAD: 109266122(FLT1)
AJU: 106985536(FLT1)
HHV: 120247154(FLT1)
BTA: 503620(FLT1)
BOM: 102269660(FLT1)
BIU: 109566823(FLT1)
BBUB: 102410059(FLT1)
CHX: 100860837(FLT1)
OAS: 443088(FLT1)
ODA: 120882914(FLT1)
CCAD: 122447130(FLT1)
SSC: 396763(FLT1)
CFR: 102508666(FLT1)
CBAI: 105066317(FLT1)
CDK: 105086584(FLT1)
VPC: 102530642(FLT1)
BACU: 103015874(FLT1)
LVE: 103079754(FLT1)
OOR: 101277470(FLT1)
DLE: 111175188(FLT1)
PCAD: 102986927(FLT1)
PSIU: 116742893(FLT1)
ECB: 100033957(FLT1)
EPZ: 103561902(FLT1)
EAI: 106832910(FLT1)
MYB: 102244559(FLT1) 102247542
MYD: 102755891 102760394(FLT1)
MMYO: 118650828(FLT1) 118654202
MLF: 102417951(FLT1) 102422327
MNA: 107534361(FLT1)
PKL: 118719986 118729025(FLT1)
HAI: 109390085 109395227(FLT1)
DRO: 112300051 112323117(FLT1)
SHON: 118986919 118995808(FLT1)
AJM: 119041773 119064949(FLT1)
PDIC: 114489006(FLT1) 114505286
PHAS: 123822657(FLT1)
MMF: 118623942(FLT1) 118635912
RFQ: 117021297(FLT1) 117026978
PALE: 102891095(FLT1) 112469042
PGIG: 120592792 120602420(FLT1)
PVP: 105292131(FLT1) 105307777
RAY: 107498919 107514322(FLT1)
MJV: 108385338
TOD: 119258799(FLT1)
SARA: 101544502(FLT1)
LAV: 100668928(FLT1)
TMU: 101352737
DNM: 101433858(FLT1)
MDO: 100017469 100025304(FLT1)
GAS: 123241274(FLT1) 123253770
SHR: 100930426(FLT1) 111721579
PCW: 110203184 110215551(FLT1)
OAA: 100090501(FLT1) 100090796
GGA: 374100(FLT1) 422316(VEGFRKDRL)
PCOC: 116229736 116244085(FLT1)
CJO: 107308289(FLT1) 107312792
NMEL: 110388861(FLT1) 110403438
APLA: 101795331(FLT1) 101797327
ACYG: 106038554 106041123(FLT1)
AFUL: 116492016(FLT1) 116494267
TGU: 100223459(FLT1) 100229347
LSR: 110467886 110476760(FLT1)
SCAN: 103816498 103827338(FLT1)
PMOA: 120506575(FLT1) 120512684
OTC: 121341965(FLT1) 121346527
PRUF: 121362872 121364149(FLT1)
GFR: 102034196 102037593(FLT1)
FAB: 101806396(FLT1) 101808610
PHI: 102108061(FLT1) 102108458
PMAJ: 107202343(FLT1) 107203705
CCW: 104689893(FLT1) 104691716
ETL: 114062430 114067520(FLT1)
ZAB: 102066332 102069571(FLT1)
FPG: 101913316 101922526(FLT1)
FCH: 102051492 102058347(FLT1)
CLV: 102087545 102094103(FLT1)
EGZ: 104126066 104133690(FLT1)
NNI: 104021082 104023019(FLT1)
ACUN: 113479969 113485269(FLT1)
TALA: 104366770(FLT1) 104367161
PADL: 103917156 103920091(FLT1)
ACHC: 115333495 115353436(FLT1)
AAM: 106489849 106500427(FLT1)
AROW: 112970206(FLT1) 112975755
NPD: 112947066 112956318(FLT1)
DNE: 112982911 112988391(FLT1)
ASN: 102368462 102372479(FLT1)
AMJ: 102561001 102566553(FLT1)
CPOO: 109305529(FLT1) 109313679
GGN: 109300700 109302231(FLT1)
PSS: 102446651 102456773(FLT1)
CMY: 102930345 102931972(FLT1)
CPIC: 101936531 101943434(FLT1)
TST: 117871080(FLT1) 117882473
CABI: 116816233(FLT1) 116819796
MRV: 120371478 120383535(FLT1)
ACS: 100556703(flt1) 100563056
PVT: 110074293 110076449(FLT1)
SUND: 121925433(FLT1) 121936578
PBI: 103048455(FLT1) 103057723
PMUR: 107282917 107294150(FLT1)
TSR: 106546359(FLT1) 106550713
PGUT: 117661708(FLT1) 117675990
VKO: 123021962 123028973(FLT1)
PMUA: 114588860 114595760(FLT1)
ZVI: 118084151 118084634(FLT1)
GJA: 107105448(FLT1) 107121841
XLA: 108698372(kdrl.L) 108700541(kdrl.S) 373789(flt1.L) 379546(flt1.S)
XTR: 100492992(flt1) 100495109(kdrl)
NPR: 108791089 108796337(FLT1)
RTEM: 120913770 120929198(FLT1)
BBUF: 120977993 120996322(FLT1)
BGAR: 122930927(FLT1) 122946033
DRE: 544667(flt1) 796537(kdrl)
IPU: 108256487(flt1) 108269076(kdrl)
PHYP: 113528886 113541212(flt1)
SMEO: 124375383(flt1) 124385940(kdrl)
AMEX: 103032355(flt1) 103038588
TRU: 101071220 101071361(flt1)
LCO: 104923474
CGOB: 115014595 115025365(flt1)
ELY: 117255381(kdrl) 117264653(flt1)
PLEP: 121947692(kdrl) 121960979(flt1)
SLUC: 116037936(flt1) 116052518(kdrl)
ECRA: 117938210(flt1) 117951764(kdrl)
PFLV: 114549359(flt1) 114562330
GAT: 120811852(flt1) 120817726(kdrl)
PPUG: 119198803(flt1) 119210622(kdrl)
MSAM: 119888301(kdrl) 119909684(flt1)
CUD: 121516665(kdrl) 121527176(flt1)
MZE: 101478748 101479515(flt1)
ONL: 100701270(flt1) 100707615
OAU: 116319752(flt1) 116324255(kdrl)
OLA: 100049480 101172940(flt1)
OML: 112151381(flt1) 112153421(kdrl)
XMA: 102219213(flt1) 102221726
XCO: 114136904(flt1) 114139259
XHE: 116711908(flt1) 116714458
PRET: 103456619(flt1) 103471632
PFOR: 103139803(flt1) 103140126
GAF: 122824253(flt1) 122837171(kdrl)
CVG: 107090808(flt1) 107092557
CTUL: 119789068(flt1) 119795774(kdrl)
GMU: 124858000(flt1) 124860351(kdrl)
NFU: 107378530 107382874(flt1)
KMR: 108230231(flt1) 108231416(kdrl)
ALIM: 106513437(flt1) 106515430
NWH: 119408904(kdrl) 119426533(flt1)
SSEN: 122778409(kdrl)
HHIP: 117753707(flt1) 117769340(kdrl)
LCF: 108872510 108881770(flt1)
SDU: 111221028(flt1) 111232404
SLAL: 111662923(flt1) 111666345
XGL: 120785138(kdrl) 120789678(flt1)
MALB: 109952200 109960158(flt1)
ELS: 105021948(flt1) 105029482
AANG: 118223172(kdrl) 118225407(flt1)
LOC: 102683866 102685646(flt1)
LCM: 102345121(FLT1) 102365485
CMK: 103178759(kdrl) 103183246(flt1)
BFO: 118419709
BBEL: 109466500
CIN: 778954
SCLV: 120341244
APLC: 110982549
DME: Dmel_CG8222(Pvr)
DER: 6543482
DSE: 6611642
DSI: Dsimw501_GD22428(Dsim_GD22428)
DSR: 110176819
DPE: 6589575
DMN: 108163426
DWI: 6641517
DGR: 6561707
DAZ: 108610455
DNV: 115563483
DHE: 111596228
DVI: 6628383
CCAT: 101462378
BOD: 106615299
MDE: 101895886
SCAC: 106082738
LCQ: 111685234
ACOZ: 120955167
AARA: 120900592
AAG: 5563777
AME: 413303
ACER: 107994676
ALAB: 122712978
BIM: 100741439
BBIF: 117215673
BVK: 117238328
BVAN: 117164708
BTER: 100646978
BPYO: 122567051
OBB: 114880994
NMEA: 116425246
CGIG: 122399641
SOC: 105207136
MPHA: 105828561
AEC: 105149416
ACEP: 105627372
PBAR: 105423752
VEM: 105563797
HST: 105190724
DQU: 106742591
CFO: 105257298
FEX: 115238084
PGC: 109851977
OBO: 105280097
PCF: 106789615
PFUC: 122516114
VPS: 122628092
NVI: 100116425
CSOL: 105364449
TPRE: 106653230
MDL: 103570507
CGLO: 123272112
FAS: 105264444
DAM: 107043041
CCIN: 107272921
TCA: 662470
SOY: 115881768
NVL: 108569966
APLN: 108737760
OTU: 111421295
BMOR: 101745869
BMAN: 114249695
MSEX: 115442606
BANY: 112056304
PMAC: 106708843
PPOT: 106100371
PXU: 106123226
PRAP: 110997017
ZCE: 119833434
HAW: 110383235
TNL: 113508407
OFU: 114351194
API: 100159169
DNX: 107173314
AGS: 114131520
RMD: 113551843
BTAB: 109032088
DCI: 103513240
CLEC: 106670705
HHAL: 106688748
FOC: 113203112
DSV: 119450045
DFR: 124500602
SDM: 118199018
CEL: CELE_F59F3.1(ver-3) CELE_T17A3.1(ver-1)
CBR: CBG_17535 CBG_17536(Cbr-ver-3)
BMY: BM_BM5314(Bm5314)
TSP: Tsp_00087
PCAN: 112559656
GAE: 121376104
HRF: 124132649
HRJ: 124274313
CRG: 105348465
MYI: 110447179
PMAX: 117329218
MMER: 123557632
OBI: 106877728
OSN: 115218235
LAK: 106159770
ATEN: 116300809
AMIL: 114973625
DGT: 114529432
HMG: 100209153
 » show all
Reference
  Authors
Habeck H, Odenthal J, Walderich B, Maischein H, Schulte-Merker S
  Title
Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis.
  Journal
Curr Biol 12:1405-12 (2002)
DOI:10.1016/s0960-9822(02)01044-8
  Sequence
[dre:796537]
Reference
  Authors
Wiesmann C, Muller YA, de Vos AM.
  Title
Ligand-binding sites in Ig-like domains of receptor tyrosine kinases.
  Journal
J Mol Med 78:247-60 (2000)
DOI:10.1007/s001090000082
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234
LinkDB

KEGG   ORTHOLOGY: K05097
Entry
K05097                      KO                                     
Symbol
FLT4, VEGFR3
Name
FMS-like tyrosine kinase 4 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map05200  Pathways in cancer
map05224  Breast cancer
Disease
H00535  Lymphatic malformation
H01471  Lymphangioma
H02199  Congenital heart defects, multiple type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
   04014 Ras signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
   04015 Rap1 signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
   04020 Calcium signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
   04151 PI3K-Akt signaling pathway
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
  09162 Cancer: specific types
   05224 Breast cancer
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05097  FLT4, VEGFR3; FMS-like tyrosine kinase 4
Genes
HSA: 2324(FLT4)
PTR: 462339(FLT4)
PPS: 100969442(FLT4)
GGO: 101130379(FLT4)
PON: 100462098(FLT4)
NLE: 100582920(FLT4)
MCC: 716412(FLT4)
MCF: 102123168(FLT4)
CSAB: 103245125(FLT4)
CATY: 105590424(FLT4)
PANU: 101025494(FLT4)
TGE: 112626121(FLT4)
RRO: 104671523(FLT4)
RBB: 108514173(FLT4)
TFN: 117064804(FLT4)
PTEH: 111527329(FLT4)
CJC: 100388404(FLT4)
SBQ: 101033672(FLT4)
MMUR: 105865757(FLT4)
OGA: 100941807(FLT4)
MMU: 14257(Flt4)
MCAL: 110304471(Flt4)
MPAH: 110331550(Flt4)
RNO: 114110(Flt4)
MCOC: 116078943(Flt4)
MUN: 110547372(Flt4)
CGE: 100766609(Flt4)
PLEU: 114681497(Flt4)
NGI: 103749361(Flt4)
HGL: 101702013(Flt4)
CPOC: 100715831(Flt4)
CCAN: 109700252(Flt4)
DORD: 105996799(Flt4)
DSP: 122115490(Flt4)
OCU: 100008829(FLT4)
OPI: 101532426(FLT4)
TUP: 102482918(FLT4)
CFA: 481464(FLT4)
VVP: 112911875(FLT4)
VLG: 121494999(FLT4)
AML: 100478767(FLT4)
UMR: 103680018(FLT4)
UAH: 113261544(FLT4)
UAR: 123790499(FLT4)
ELK: 111158898
LLV: 125100265
MPUF: 101674061(FLT4)
ORO: 101382368(FLT4)
EJU: 114201213(FLT4)
ZCA: 113929766(FLT4)
MLX: 118026502(FLT4)
FCA: 101094727(FLT4)
PBG: 122485844(FLT4)
PTG: 102960922(FLT4)
PPAD: 109278978(FLT4)
AJU: 106970218(FLT4)
HHV: 120225370(FLT4)
BTA: 338031(FLT4)
BOM: 102267985(FLT4)
BIU: 109561327(FLT4)
BBUB: 102402057(FLT4)
CHX: 102180480(FLT4)
OAS: 101117247(FLT4)
ODA: 120864345(FLT4)
CCAD: 122440569(FLT4)
SSC: 100518179(FLT4)
CFR: 102504702(FLT4)
CBAI: 105061997(FLT4)
CDK: 105100622(FLT4)
VPC: 102527355(FLT4)
BACU: 103004554(FLT4)
LVE: 103074358(FLT4)
OOR: 101272910(FLT4)
DLE: 111170902(FLT4)
PCAD: 102988868(FLT4)
PSIU: 116752252(FLT4)
ECB: 100066773(FLT4)
EPZ: 103566205(FLT4)
EAI: 106843734(FLT4)
MYB: 102244912(FLT4)
MYD: 102756633(FLT4)
MMYO: 118658880(FLT4)
MLF: 102430005(FLT4)
MNA: 107528437(FLT4)
PKL: 118725927(FLT4)
HAI: 109392740(FLT4)
DRO: 112296393(FLT4)
SHON: 118995107(FLT4)
AJM: 119042619(FLT4)
PDIC: 114509396(FLT4)
PHAS: 123811159(FLT4)
MMF: 118643768(FLT4)
RFQ: 117016973(FLT4)
PALE: 102889771(FLT4)
PGIG: 120616609(FLT4)
PVP: 105300011(FLT4)
RAY: 107512332(FLT4)
MJV: 108408755(FLT4)
TOD: 119235094(FLT4)
SARA: 101549127(FLT4)
LAV: 100677038(FLT4)
TMU: 101340931
DNM: 101444399
MDO: 100032078(FLT4)
GAS: 123233760(FLT4)
SHR: 100932306(FLT4)
PCW: 110216702(FLT4)
OAA: 100087557(FLT4)
GGA: 395742(FLT4)
PCOC: 116232158(FLT4)
MGP: 100543111(FLT4)
CJO: 107320206(FLT4)
NMEL: 110405266(FLT4)
APLA: 101790164(FLT4)
ACYG: 106032675(FLT4)
AFUL: 116494987(FLT4)
TGU: 100218470(FLT4)
LSR: 110482723(FLT4)
SCAN: 103817296(FLT4)
PMOA: 120498567(FLT4)
OTC: 121332253(FLT4)
PRUF: 121361337(FLT4)
GFR: 102039974(FLT4)
FAB: 101808166(FLT4)
PHI: 102110772(FLT4)
PMAJ: 107210757(FLT4)
CCAE: 111935550(FLT4)
CCW: 104689586(FLT4)
ETL: 114063191(FLT4)
ZAB: 102073174(FLT4)
FPG: 101918084(FLT4)
FCH: 102053583(FLT4)
CLV: 102090209(FLT4)
EGZ: 104123344(FLT4)
NNI: 104014191(FLT4)
ACUN: 113485325(FLT4)
TALA: 104363406(FLT4)
PADL: 103915749(FLT4)
ACHC: 115334261(FLT4)
AAM: 106493463(FLT4)
AROW: 112964877(FLT4)
NPD: 112954364(FLT4)
DNE: 112996952(FLT4)
ASN: 102373975(FLT4)
AMJ: 102567838(FLT4)
CPOO: 109310155(FLT4)
GGN: 109289764(FLT4)
PSS: 102459372(FLT4)
CMY: 102944420(FLT4)
CPIC: 101942381(FLT4)
TST: 117881465(FLT4)
CABI: 116820037(FLT4)
MRV: 120370388(FLT4)
ACS: 100556373(flt4)
PVT: 110073488(FLT4)
SUND: 121923433(FLT4)
PBI: 103068185
PMUR: 107296517(FLT4)
TSR: 106538654(FLT4)
PGUT: 117655288(FLT4)
VKO: 123035695(FLT4)
PMUA: 114591336(FLT4)
ZVI: 118080415(FLT4)
GJA: 107110308(FLT4)
XTR: 100493801(flt4)
NPR: 108785383(FLT4)
RTEM: 120932539(FLT4)
BBUF: 121008332(FLT4)
BGAR: 122928355(FLT4)
DRE: 30121(flt4)
IPU: 108268674(flt4)
PHYP: 113542868(flt4)
SMEO: 124385843(flt4)
AMEX: 103037902
EEE: 113576525(flt4)
TRU: 101079004(flt4)
LCO: 104930066(flt4)
NCC: 104959310
CGOB: 115014811(flt4)
ELY: 117261175(flt4)
PLEP: 121947759(flt4)
SLUC: 116064227(flt4)
ECRA: 117951482(flt4)
PFLV: 114562616(flt4)
GAT: 120817506(flt4)
PPUG: 119211402(flt4)
MSAM: 119888532 119889380(flt4)
CUD: 121516363(flt4)
MZE: 101463681(flt4)
ONL: 100711033(flt4)
OAU: 116324570(flt4)
OLA: 100335137(flt4)
OML: 112153290(flt4)
XMA: 102233039(flt4)
XCO: 114139113(flt4)
XHE: 116714078(flt4)
PRET: 103471109(flt4)
PFOR: 103144544(flt4)
PLAI: 106947099(flt4)
PMEI: 106929681
GAF: 122836737(flt4)
CVG: 107093459(flt4)
CTUL: 119783199(flt4)
GMU: 124860198(flt4)
NFU: 107385122(flt4)
KMR: 108242065(flt4)
ALIM: 106515980(flt4)
NWH: 119408275(flt4)
AOCE: 111578770(flt4)
CSEM: 103391112(flt4)
POV: 109624596(flt4)
SSEN: 122778344(flt4)
HHIP: 117768812(flt4)
LCF: 108882862(flt4)
SDU: 111226519(flt4)
SLAL: 111652030(flt4)
XGL: 120785825(flt4)
HCQ: 109515935(flt4)
BPEC: 110163041(flt4)
MALB: 109968381
SASA: 106612321
OTW: 112238407
OMY: 110487799 110515335(flt4)
ELS: 105026780(flt4)
SFM: 108930359(flt4)
PKI: 111857710(flt4)
AANG: 118223170(flt4)
LOC: 102698950(flt4)
LCM: 102359993(FLT4)
CMK: 103188224
RTP: 109927679(flt4)
AEC: 105155038
DMK: 116923638
PJA: 122259726
RSAN: 119381619
BGT: 106061451
SPIS: 111344794
 » show all
Reference
PMID:1319394
  Authors
Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D
  Title
Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.
  Journal
Genomics 13:475-8 (1992)
DOI:10.1016/0888-7543(92)90277-Y
  Sequence
[hsa:2324]
LinkDB

KEGG   ORTHOLOGY: K05098
Entry
K05098                      KO                                     
Symbol
KDR, VEGFR2, CD309
Name
kinase insert domain protein receptor [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04370  VEGF signaling pathway
map04510  Focal adhesion
map05205  Proteoglycans in cancer
map05418  Fluid shear stress and atherosclerosis
Disease
H01482  Infantile hemangioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04014 Ras signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04015 Rap1 signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04370 VEGF signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04020 Calcium signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04151 PI3K-Akt signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
CD molecules [BR:ko04090]
 Proteins
  K05098  CD309, KDR; kinase insert domain receptor (a type III receptor tyrosine kinase)
Genes
HSA: 3791(KDR)
PTR: 461315(KDR)
PPS: 100986594(KDR)
GGO: 101127110(KDR)
PON: 100462446(KDR)
NLE: 100604569(KDR)
MCC: 698293(KDR)
MCF: 102136227(KDR)
CSAB: 103235670(KDR)
CATY: 105591984(KDR)
PANU: 101021364(KDR)
TGE: 112624522(KDR)
RRO: 104662002(KDR)
RBB: 108531591(KDR)
TFN: 117085601(KDR)
PTEH: 111526494(KDR)
CJC: 100407045(KDR)
SBQ: 101036336(KDR)
CSYR: 103249186(KDR)
MMUR: 105867839(KDR)
OGA: 100944640(KDR)
MMU: 16542(Kdr)
MCAL: 110294607(Kdr)
MPAH: 110330463(Kdr)
RNO: 25589(Kdr)
MCOC: 116071284(Kdr)
MUN: 110556944(Kdr)
CGE: 100756294(Kdr)
PLEU: 114683507(Kdr)
NGI: 103734390(Kdr)
HGL: 101726029(Kdr)
CPOC: 100726761(Kdr)
CCAN: 109698964(Kdr)
DORD: 105980311(Kdr)
DSP: 122106648(Kdr)
OCU: 100008607(KDR)
OPI: 101525767(KDR)
TUP: 102489981(KDR)
CFA: 482154(KDR)
VVP: 112923722(KDR)
VLG: 121473247(KDR)
AML: 100484938(KDR)
UMR: 103672740(KDR)
UAH: 113262503(KDR)
UAR: 123803979(KDR)
ELK: 111149192
LLV: 125093732
MPUF: 101676197(KDR)
ORO: 101371459(KDR)
EJU: 114206757(KDR)
ZCA: 113924698(KDR)
MLX: 118010519(KDR)
FCA: 101090260(KDR)
PYU: 121035518(KDR)
PBG: 122478869(KDR)
PTG: 102955197(KDR)
PPAD: 109278955(KDR)
AJU: 106983987(KDR)
HHV: 120243048(KDR)
BTA: 407170(KDR)
BOM: 102288007(KDR)
BIU: 109560478(KDR)
BBUB: 102412057(KDR)
CHX: 100860836(KDR)
OAS: 443087(KDR)
ODA: 120862130(KDR)
CCAD: 122428068(KDR)
SSC: 397311(KDR)
CFR: 102520881(KDR)
CBAI: 105077731(KDR)
CDK: 105091598(KDR)
VPC: 102537256(KDR)
BACU: 102999852(KDR)
LVE: 103087802(KDR)
OOR: 101290288(KDR)
DLE: 111169643(KDR)
PCAD: 102986785(KDR)
PSIU: 116754436(KDR)
ECB: 100033959(KDR)
EPZ: 103554974(KDR)
EAI: 106836923(KDR)
MYB: 102256532(KDR)
MYD: 102760801(KDR)
MMYO: 118668891(KDR)
MLF: 102442473(KDR)
MNA: 107532764(KDR)
PKL: 118706596(KDR)
HAI: 109381812(KDR)
DRO: 112316796(KDR)
SHON: 118978574(KDR)
AJM: 119044890(KDR)
PDIC: 114492293(KDR)
PHAS: 123815784(KDR)
MMF: 118639624(KDR)
RFQ: 117022432(KDR)
PALE: 102896638(KDR)
PGIG: 120588082(KDR)
PVP: 105293771(KDR)
RAY: 107520899(KDR)
MJV: 108400781(KDR)
TOD: 119261390(KDR)
SARA: 101547149(KDR)
LAV: 100656232(KDR)
TMU: 101348626
DNM: 101426854(KDR)
MDO: 100017311(KDR)
GAS: 123252924(KDR)
SHR: 100929091(KDR)
PCW: 110200147(KDR)
OAA: 100075389(KDR)
GGA: 395323(KDR)
PCOC: 116225918(KDR)
CJO: 107313758(KDR)
NMEL: 110398187(KDR)
APLA: 101797579(KDR)
ACYG: 106030825(KDR)
AFUL: 116489139(KDR)
TGU: 100231879(KDR)
LSR: 110470474(KDR)
SCAN: 103825225(KDR)
PMOA: 120497438(KDR)
OTC: 121334972(KDR)
PRUF: 121356907(KDR)
GFR: 102042381(KDR)
FAB: 101821250(KDR)
PHI: 102113293(KDR)
PMAJ: 107202958(KDR)
CCAE: 111928018(KDR)
CCW: 104690864(KDR)
ETL: 114058319(KDR)
ZAB: 102072118(KDR)
FPG: 101920584(KDR)
FCH: 102059103(KDR)
CLV: 102095316(KDR)
EGZ: 104129460(KDR)
NNI: 104020821(KDR)
ACUN: 113479117(KDR)
TALA: 104366307(KDR)
PADL: 103926348(KDR)
ACHC: 115343684(KDR)
AAM: 106490175
AROW: 112974609(KDR)
NPD: 112942612(KDR)
DNE: 112979497(KDR)
ASN: 102384502(KDR)
AMJ: 102567818(KDR)
CPOO: 109322249(KDR)
GGN: 109303986(KDR)
PSS: 102451309(KDR)
CMY: 102936088(KDR)
CPIC: 101936813(KDR)
TST: 117877988(KDR)
CABI: 116826031(KDR)
MRV: 120406892(KDR)
SUND: 121931586(KDR)
PGUT: 117662069(KDR)
VKO: 123017072(KDR)
ZVI: 118083754(KDR)
XLA: 108698463 108706593(kdr.S)
XTR: 100487501(kdr)
NPR: 108803904(KDR)
RTEM: 120922871(KDR)
BBUF: 120990207(KDR)
BGAR: 122941781(KDR)
DRE: 554230(kdr)
SGH: 107601907(kdr)
IPU: 108258084(kdr)
PHYP: 113546829(kdr)
SMEO: 124376967(kdr)
AMEX: 103022603(kdr)
EEE: 113586383(kdr)
TRU: 101073989(kdr)
LCO: 104919091(kdr)
NCC: 104947077(kdr)
CGOB: 115007113(kdr)
ELY: 117254002(kdr)
PLEP: 121940403(kdr)
SLUC: 116058785(kdr)
ECRA: 117950140(kdr)
PFLV: 114561463(kdr)
GAT: 120824144(kdr)
PPUG: 119216901(kdr)
MSAM: 119901062(kdr)
CUD: 121512496(kdr)
MZE: 101472847(kdr)
ONL: 100692052(kdr)
OAU: 116331100(kdr)
OLA: 101162439(kdr)
OML: 112136996(kdr)
XMA: 102225837(kdr)
XCO: 114151198(kdr)
XHE: 116726174(kdr)
PRET: 103463836(kdr)
PFOR: 103137114(kdr)
PLAI: 106963463(kdr)
PMEI: 106924169(kdr)
GAF: 122838442(kdr)
CVG: 107091574(kdr)
CTUL: 119780621(kdr)
GMU: 124874157(kdr)
NFU: 107393390(kdr)
KMR: 108243429(kdr)
ALIM: 106534849(kdr)
NWH: 119408213(kdr)
AOCE: 111569594(kdr)
CSEM: 103376704(kdr)
POV: 109625885(kdr)
SSEN: 122781150(kdr)
HHIP: 117759682(kdr)
LCF: 108879132(kdr)
SDU: 111226355(kdr)
SLAL: 111644356(kdr)
XGL: 120790993(kdr)
HCQ: 109532106(kdr)
BPEC: 110154739(kdr)
MALB: 109962035(kdr)
SASA: 106584120(kdr)
OTW: 112249135(kdr)
OMY: 110521673(kdr)
OGO: 124037859(kdr)
ONE: 115145130(kdr)
SALP: 111972318
SNH: 120052584(kdr)
ELS: 105011839(kdr)
SFM: 108922800(kdr)
PKI: 111850117(kdr)
AANG: 118225803(kdr)
LOC: 102682636(kdr)
LCM: 102362684(KDR)
CMK: 103178168(kdr)
RTP: 109928943(kdr)
VPS: 122629567
NVI: 100123205
HMG: 100214305
 » show all
Reference
PMID:1656371
  Authors
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB
  Title
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
  Journal
Oncogene 6:1677-83 (1991)
  Sequence
[hsa:3791]
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234
LinkDB

KEGG   ORTHOLOGY: K03176
Entry
K03176                      KO                                     
Symbol
NTRK1, TRKA
Name
neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04722  Neurotrophin signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05216  Thyroid cancer
map05230  Central carbon metabolism in cancer
Disease
H00032  Thyroid cancer
H00043  Neuroblastoma
H00265  Hereditary sensory and autonomic neuropathy
H01836  Congenital pain insensitivity with anhidrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04014 Ras signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04020 Calcium signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   04151 PI3K-Akt signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05202 Transcriptional misregulation in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
   05230 Central carbon metabolism in cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
  09162 Cancer: specific types
   05216 Thyroid cancer
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K03176  NTRK1, TRKA; neurotrophic tyrosine kinase receptor type 1
Genes
HSA: 4914(NTRK1)
PTR: 457408(NTRK1)
GGO: 101125993(NTRK1)
PON: 100452269(NTRK1)
NLE: 100585466(NTRK1)
MCC: 719670(NTRK1)
MCF: 102129364(NTRK1)
CSAB: 103223823(NTRK1)
CATY: 105594539(NTRK1)
PANU: 101012772(NTRK1)
TGE: 112607006(NTRK1)
RRO: 104676442(NTRK1)
RBB: 108515538(NTRK1)
TFN: 117076785(NTRK1)
PTEH: 111543817(NTRK1)
CJC: 103789024(NTRK1)
SBQ: 101035626(NTRK1)
CSYR: 103251204(NTRK1)
MMUR: 105873105(NTRK1)
OGA: 100940422(NTRK1)
MMU: 18211(Ntrk1)
MCAL: 110290875(Ntrk1)
MPAH: 110319787(Ntrk1)
RNO: 59109(Ntrk1)
MUN: 110564977(Ntrk1)
CGE: 100751271(Ntrk1)
PLEU: 114683361(Ntrk1)
NGI: 103750263(Ntrk1)
HGL: 101724441(Ntrk1)
CPOC: 100725325(Ntrk1)
CCAN: 109686202(Ntrk1)
DORD: 105996438(Ntrk1)
DSP: 122109658(Ntrk1)
OCU: 100354292(NTRK1)
OPI: 101528482(NTRK1)
TUP: 102485200(NTRK1)
CFA: 490404(NTRK1)
VVP: 112918800(NTRK1)
VLG: 121484071(NTRK1)
UAH: 113245211(NTRK1)
UAR: 123783398(NTRK1)
ELK: 111138872
LLV: 125085737
MPUF: 101684239(NTRK1)
ORO: 101374117(NTRK1)
EJU: 114198649(NTRK1)
ZCA: 113932722(NTRK1)
MLX: 118013921(NTRK1)
FCA: 101081603(NTRK1)
PYU: 121015457(NTRK1)
PBG: 122475682(NTRK1)
PPAD: 109256209(NTRK1)
AJU: 106988854(NTRK1)
HHV: 120244665(NTRK1)
BTA: 353111(NTRK1)
BOM: 102264869(NTRK1)
BIU: 109556725(NTRK1)
BBUB: 102402551(NTRK1)
CHX: 102172584(NTRK1)
OAS: 101109763(NTRK1)
ODA: 120855667(NTRK1)
CCAD: 122431869(NTRK1)
SSC: 100154471(NTRK1)
CFR: 102518397(NTRK1)
CBAI: 105068230(NTRK1)
CDK: 105105672(NTRK1)
VPC: 102543920(NTRK1)
BACU: 103003654(NTRK1)
LVE: 103071756(NTRK1)
OOR: 101273503(NTRK1)
DLE: 111167102(NTRK1)
PCAD: 102990275(NTRK1)
PSIU: 116756746(NTRK1)
ECB: 100064594(NTRK1)
EPZ: 103548862(NTRK1)
EAI: 106828447(NTRK1)
MYD: 102765751(NTRK1)
MMYO: 118673526(NTRK1)
MLF: 102431497(NTRK1)
MNA: 107543738(NTRK1)
PKL: 118721515(NTRK1)
HAI: 109393379(NTRK1)
DRO: 112315668(NTRK1)
AJM: 119039739(NTRK1)
PDIC: 114489015(NTRK1)
PHAS: 123804735(NTRK1)
MMF: 118637108(NTRK1)
RFQ: 117014296(NTRK1)
PALE: 112472150(NTRK1)
PGIG: 120606120(NTRK1)
PVP: 105296416(NTRK1)
RAY: 107521477(NTRK1)
MJV: 108383338(NTRK1)
TOD: 119236305(NTRK1)
SARA: 101540859(NTRK1)
LAV: 100668650(NTRK1)
TMU: 101351378
DNM: 101425856(NTRK1)
MDO: 100618744(NTRK1)
GAS: 123246086(NTRK1)
SHR: 100916388(NTRK1)
PCW: 110212119(NTRK1)
OAA: 103167743
GGA: 396337(NTRK1)
PCOC: 116237273(NTRK1)
MGP: 100541244(NTRK1)
CJO: 107324385(NTRK1)
NMEL: 110388022(NTRK1)
AFUL: 116499797(NTRK1)
TGU: 115498457(NTRK1)
LSR: 110471556(NTRK1)
SCAN: 103824820(NTRK1)
PMOA: 120498961(NTRK1)
OTC: 121332151(NTRK1)
PRUF: 121352173(NTRK1)
GFR: 102039729(NTRK1)
FAB: 101810326(NTRK1)
PHI: 102113646(NTRK1)
PMAJ: 107214529(NTRK1)
CCAE: 111939539
ETL: 114071558(NTRK1)
ZAB: 113460658(NTRK1)
FPG: 101920297(NTRK1)
FCH: 102060232(NTRK1)
CLV: 102086876(NTRK1)
NNI: 104015011(NTRK1)
TALA: 116965970(NTRK1)
ACHC: 115345406(NTRK1)
AAM: 106495087(NTRK1)
AROW: 112969974(NTRK1)
NPD: 112953544(NTRK1)
DNE: 112990827(NTRK1)
ASN: 102381668(NTRK1)
AMJ: 102568424(NTRK1)
CPOO: 109324023(NTRK1)
GGN: 109298723(NTRK1)
PSS: 102456174(NTRK1)
CMY: 102940175(NTRK1)
CPIC: 101934097(NTRK1)
TST: 117869852(NTRK1)
CABI: 116831884(NTRK1)
MRV: 120390665(NTRK1)
ACS: 100556611(ntrk1)
PVT: 110081467(NTRK1)
SUND: 121916146(NTRK1)
PBI: 103064232(NTRK1)
PMUR: 107298512(NTRK1)
TSR: 106540381
PGUT: 117670110(NTRK1)
PMUA: 114586656(NTRK1)
ZVI: 118094598(NTRK1)
GJA: 107114884(NTRK1)
XLA: 108699388(ntrk1.L) 108700358(ntrk1.S)
XTR: 100489637(ntrk1)
NPR: 108802180(NTRK1)
RTEM: 120920783(NTRK1)
BBUF: 120981563(NTRK1)
BGAR: 122921449(NTRK1)
DRE: 30546(ntrk1)
SRX: 107726660(ntrk1) 107728446
IPU: 108256584(ntrk1)
PHYP: 113532627(ntrk1)
SMEO: 124403851(ntrk1)
AMEX: 103025260(ntrk1)
EEE: 113571898(ntrk1)
TRU: 101074407(ntrk1)
LCO: 104933369(ntrk1)
NCC: 104949794(ntrk1)
CGOB: 115021582(ntrk1)
ELY: 117265685(ntrk1)
PLEP: 121945177(ntrk1)
SLUC: 116036003(ntrk1)
ECRA: 117945668(ntrk1)
PFLV: 114557434(ntrk1)
GAT: 120810204(ntrk1)
PPUG: 119197939(ntrk1)
MSAM: 119897108(ntrk1)
CUD: 121513058(ntrk1)
MZE: 101473195(ntrk1)
ONL: 100699013(ntrk1)
OAU: 116315384(ntrk1)
OLA: 101164184(ntrk1)
OML: 112136520(ntrk1)
XMA: 102217423
XCO: 114141649(ntrk1)
XHE: 116716954
PRET: 103477579(ntrk1)
PFOR: 103150831
PLAI: 106954407
PMEI: 106919456
GAF: 122830607(ntrk1)
CVG: 107101837(ntrk1)
CTUL: 119796673(ntrk1)
GMU: 124865367(ntrk1)
NFU: 107379148(ntrk1)
KMR: 108246005(ntrk1)
ALIM: 106528305(ntrk1)
NWH: 119409238(ntrk1)
AOCE: 111579099(ntrk1)
CSEM: 103388944(ntrk1)
POV: 109642014(ntrk1)
SSEN: 122775185(ntrk1)
HHIP: 117776253(ntrk1)
LCF: 108899467(ntrk1)
SDU: 111222591(ntrk1)
SLAL: 111655673(ntrk1)
XGL: 120784416(ntrk1)
HCQ: 109512189(ntrk1)
BPEC: 110172749
MALB: 109965566(ntrk1)
OTW: 112222988(ntrk1) 112223654
OMY: 110487707(ntrk1) 110503966
ELS: 105019278(ntrk1)
SFM: 108926773(ntrk1) 108930374
AANG: 118234166(ntrk1)
LOC: 102683487(ntrk1)
PSPA: 121309852(ntrk1)
LCM: 102354132(NTRK1)
BBEL: 109465943
AME: 725720
BIM: 100746731
BTER: 100645995
CCAL: 108631595
SOC: 105208070
MPHA: 105837008
AEC: 105142993
ACEP: 105627688
HST: 105184311
CFO: 105252670
FEX: 115243626
LHU: 105678901
CSOL: 105359701
FAS: 105267403
AGS: 114133003
HAZT: 108672725
DSV: 119444986
RSAN: 119379220
RMP: 119176617
VDE: 111246321
SDM: 118204971
BGT: 106065012
GAE: 121387037
 » show all
Reference
  Authors
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
  Title
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
  Journal
Cancer Cell 6:347-60 (2004)
DOI:10.1016/j.ccr.2004.09.011
  Sequence
[hsa:4914]
LinkDB

KEGG   ORTHOLOGY: K04360
Entry
K04360                      KO                                     
Symbol
NTRK2, TRKB
Name
neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04722  Neurotrophin signaling pathway
map05034  Alcoholism
Disease
H00043  Neuroblastoma
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04014 Ras signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04020 Calcium signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04151 PI3K-Akt signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 09160 Human Diseases
  09165 Substance dependence
   05034 Alcoholism
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Genes
HSA: 4915(NTRK2)
PTR: 735394(NTRK2)
PPS: 100994887(NTRK2)
GGO: 101140182(NTRK2)
PON: 100441207(NTRK2)
NLE: 100605330(NTRK2)
MCC: 709757(NTRK2)
MCF: 102132446(NTRK2)
CSAB: 103219672(NTRK2)
CATY: 105584243(NTRK2)
PANU: 101009383(NTRK2)
TGE: 112607806(NTRK2)
RRO: 104673903(NTRK2)
RBB: 108520515(NTRK2)
TFN: 117098409(NTRK2)
PTEH: 111554169(NTRK2)
CJC: 100388984(NTRK2)
SBQ: 101053284(NTRK2)
CSYR: 103256424(NTRK2)
OGA: 100956865(NTRK2)
MMU: 18212(Ntrk2)
MCAL: 110307883(Ntrk2)
MPAH: 110333600(Ntrk2)
RNO: 25054(Ntrk2)
MCOC: 116082168(Ntrk2)
CGE: 100754339(Ntrk2)
PLEU: 114688557(Ntrk2)
NGI: 103747093(Ntrk2)
HGL: 101720037(Ntrk2)
CCAN: 109677416(Ntrk2)
DORD: 105996846(Ntrk2)
DSP: 122122111(Ntrk2)
OCU: 100352548(NTRK2)
OPI: 101517963(NTRK2)
TUP: 102497563
CFA: 484147(NTRK2)
VVP: 112908664(NTRK2)
VLG: 121484579(NTRK2)
AML: 100477127(NTRK2)
UMR: 103667631(NTRK2)
UAH: 113269802(NTRK2)
UAR: 123781399
ELK: 111153613
LLV: 125083535
MPUF: 101674211(NTRK2)
ORO: 101364921(NTRK2)
EJU: 114223345(NTRK2)
ZCA: 113934282(NTRK2)
MLX: 118023317(NTRK2)
FCA: 101101347(NTRK2)
PYU: 121014214(NTRK2)
PBG: 122474678(NTRK2)
PTG: 102950315(NTRK2)
PPAD: 109251704(NTRK2)
AJU: 106978572(NTRK2)
HHV: 120224500(NTRK2)
BTA: 505824(NTRK2)
BOM: 102269089(NTRK2)
BIU: 109563216(NTRK2)
BBUB: 102416668(NTRK2)
CHX: 102180223(NTRK2)
OAS: 101116015(NTRK2)
ODA: 120866819(NTRK2)
CCAD: 122431778(NTRK2)
SSC: 100519209(NTRK2)
CFR: 102507254(NTRK2)
CBAI: 105078857(NTRK2)
CDK: 105100473(NTRK2)
VPC: 102536840(NTRK2)
BACU: 103020777(NTRK2)
LVE: 103069787
OOR: 101281465(NTRK2)
DLE: 111166804(NTRK2)
PCAD: 102987032(NTRK2)
PSIU: 116755336(NTRK2)
ECB: 100061700(NTRK2)
EPZ: 103551809(NTRK2)
EAI: 106822031(NTRK2)
MYB: 102238774(NTRK2)
MYD: 102755544(NTRK2)
MMYO: 118667416(NTRK2)
MLF: 102426842(NTRK2)
MNA: 107545009(NTRK2)
PKL: 118716438(NTRK2)
DRO: 112304477(NTRK2)
SHON: 118979587(NTRK2)
AJM: 119060018(NTRK2)
PDIC: 114492084(NTRK2)
PHAS: 123820257(NTRK2)
MMF: 118629607(NTRK2)
RFQ: 117032168(NTRK2)
PALE: 102882910(NTRK2)
PGIG: 120612943(NTRK2)
PVP: 105300054(NTRK2)
RAY: 107502751(NTRK2)
MJV: 108400418(NTRK2)
TOD: 119231413 119232387(NTRK2)
SARA: 101538939(NTRK2)
LAV: 100675363(NTRK2)
TMU: 101342178
DNM: 101424677
MDO: 100029389(NTRK2)
GAS: 123232189(NTRK2)
SHR: 100927322(NTRK2)
PCW: 110194558(NTRK2)
OAA: 100080080(NTRK2)
GGA: 396157(NTRK2)
PCOC: 116234674(NTRK2)
MGP: 100545915(NTRK2)
CJO: 107306253(NTRK2)
NMEL: 110389852(NTRK2)
APLA: 101797842(NTRK2)
ACYG: 106045383(NTRK2)
AFUL: 116500354(NTRK2)
TGU: 751985(NTRK2)
LSR: 110472599(NTRK2)
SCAN: 103822953(NTRK2)
PMOA: 120511955(NTRK2)
OTC: 121332035(NTRK2)
PRUF: 121360713(NTRK2)
GFR: 102044793(NTRK2)
FAB: 101810339(NTRK2)
PHI: 102100533(NTRK2)
PMAJ: 107216220(NTRK2)
CCAE: 111940854(NTRK2)
CCW: 104692002(NTRK2)
ETL: 114055895(NTRK2)
ZAB: 102071660(NTRK2)
FPG: 101919319(NTRK2)
FCH: 102055826(NTRK2)
CLV: 102092182(NTRK2)
EGZ: 104135554(NTRK2)
NNI: 104011761(NTRK2) 104013813
ACUN: 113490005(NTRK2)
TALA: 104360530(NTRK2)
PADL: 103920397(NTRK2)
ACHC: 115336699(NTRK2)
AROW: 112976815(NTRK2)
NPD: 112942772(NTRK2)
DNE: 112978757(NTRK2)
ASN: 102372380
AMJ: 102559730(NTRK2)
CPOO: 109323426(NTRK2)
GGN: 109297554(NTRK2)
PSS: 102446411(NTRK2)
CMY: 102937131(NTRK2)
CPIC: 101947563(NTRK2)
TST: 117879171(NTRK2)
CABI: 116819442(NTRK2)
MRV: 120407553(NTRK2)
ACS: 100558067(ntrk2)
PVT: 110089898(NTRK2)
SUND: 121922417(NTRK2)
PBI: 103063871(NTRK2)
PMUR: 107294568(NTRK2)
TSR: 106556809(NTRK2)
PGUT: 117661392(NTRK2)
VKO: 123031550(NTRK2)
PMUA: 114606265(NTRK2)
ZVI: 118076712(NTRK2)
GJA: 107117206(NTRK2)
XLA: 379266(ntrk2.L) 779173(ntrk2.S)
XTR: 780110(ntrk2)
NPR: 108798612(NTRK2)
RTEM: 120942448(NTRK2)
BBUF: 120989115(NTRK2)
BGAR: 122922907(NTRK2)
DRE: 570240(ntrk2b) 65090(ntrk2a)
IPU: 108259739(ntrk2b) 108265887(ntrk2a)
PHYP: 113531639 113533488(ntrk2)
SMEO: 124378880(ntrk2b) 124399876(ntrk2a)
AMEX: 103036414(ntrk2) 103044160
EEE: 113578767(ntrk2) 113586931
TRU: 101077811(ntrk2) 101078202
LCO: 104920263(ntrk2) 109141561
CGOB: 115013223(ntrk2) 115016885
ELY: 117252134(ntrk2a) 117269771(ntrk2b)
PLEP: 121944306(ntrk2a) 121960280(ntrk2b)
SLUC: 116056646(ntrk2a) 116062849(ntrk2b)
ECRA: 117944365(ntrk2a) 117959577(ntrk2b)
PFLV: 114556221(ntrk2) 114571365
GAT: 120830317(ntrk2a) 120831671(ntrk2b)
PPUG: 119224481(ntrk2a) 119226742(ntrk2b)
MSAM: 119892041(ntrk2a) 119914353(ntrk2b)
CUD: 121509635(ntrk2a) 121525675(ntrk2b)
ONL: 100692708(ntrk2) 100697438
OAU: 116331856(ntrk2b) 116336448(ntrk2a)
OLA: 101159930 101172248(ntrk2)
OML: 112148088(ntrk2a) 112163033(ntrk2b)
XMA: 102228507(ntrk2) 102229659
XCO: 114149964 114154115(ntrk2)
XHE: 116724170 116729328(ntrk2)
PRET: 103470214(ntrk2) 103473467
PFOR: 103135387(ntrk2) 103155137
PLAI: 106953461(ntrk2) 106954505
PMEI: 106912368 106922120(ntrk2)
GAF: 122827783(ntrk2a) 122846831(ntrk2b)
CVG: 107084447(ntrk2) 107088955
CTUL: 119776552(ntrk2b) 119796910(ntrk2a)
GMU: 124872807(ntrk2b) 124878106(ntrk2a)
NFU: 107374736 107394032(ntrk2)
KMR: 108231044(ntrk2b) 108234558(ntrk2a)
NWH: 119413056(ntrk2a) 119424497(ntrk2b)
AOCE: 111564839 111567414(ntrk2)
SSEN: 122757981(ntrk2b) 122770195(ntrk2a)
HHIP: 117767472(ntrk2a) 117771866(ntrk2b)
LCF: 108873999 108878348(ntrk2)
SDU: 111230804(ntrk2) 111239875
SLAL: 111656813 111660950(ntrk2)
XGL: 120804936(ntrk2a) 120806465(ntrk2b)
HCQ: 109514240(ntrk2) 109527923
BPEC: 110153486(ntrk2) 110157504
MALB: 109961608(ntrk2) 109972366
OMY: 110523884(ntrk2b) 110525378(ntrk2a) 110535778 110537044
ELS: 105014455(ntrk2) 105027931
SFM: 108931316 108938645(ntrk2)
PKI: 111839208(ntrk2) 111851431
AANG: 118206745(ntrk2a) 118212214
LOC: 102691261(ntrk2)
PSPA: 121299406(ntrk2a) 121318701
LCM: 102363882(NTRK2)
CMK: 103187358(ntrk2a)
RTP: 109920280
SPU: 100888955
APLC: 110977267
SKO: 100313758
NMEA: 116431749
BANY: 112058262
HAW: 110371076
DCI: 103517546
FOC: 113207112
DMK: 116918505
PJA: 122251810
PCLA: 123750093
PTRU: 123500113
RSAN: 119389529
RMP: 119182182
VDE: 111251411
VJA: 111261551
TUT: 107362661
DPTE: 113794850
DFR: 124497869
GAE: 121388970
HRF: 124149853
HRJ: 124257404
CRG: 105334570
MMER: 123565360
OBI: 106877811
 » show all
Reference
PMID:8287802
  Authors
Dechant G, Biffo S, Okazawa H, Kolbeck R, Pottgiesser J, Barde YA
  Title
Expression and binding characteristics of the BDNF receptor chick trkB.
  Journal
Development 119:545-58 (1993)
  Sequence
[gga:396157]
Reference
  Authors
Chen Z, Simmons MS, Perry RT, Wiener HW, Harrell LE, Go RC
  Title
Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease.
  Journal
Am J Med Genet B Neuropsychiatr Genet 147:363-9 (2008)
DOI:10.1002/ajmg.b.30607
LinkDB

KEGG   ORTHOLOGY: K05101
Entry
K05101                      KO                                     
Symbol
NTRK3, TRKC
Name
neurotrophic tyrosine kinase, receptor type 3 [EC:2.7.10.1]
Pathway
map04020  Calcium signaling pathway
map04722  Neurotrophin signaling pathway
map05230  Central carbon metabolism in cancer
Disease
H00043  Neuroblastoma
H01508  Salivary gland cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05101  NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K05101  NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K05101  NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05101  NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05101  NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K05101  NTRK3, TRKC; neurotrophic tyrosine kinase, receptor type 3
Genes
HSA: 4916(NTRK3)
PTR: 467751(NTRK3)
PPS: 100994282(NTRK3)
GGO: 101140115(NTRK3)
PON: 100458353(NTRK3)
NLE: 100585046(NTRK3)
MCC: 697615(NTRK3)
MCF: 102122449(NTRK3)
CSAB: 103231127(NTRK3)
CATY: 105592428(NTRK3)
PANU: 101013710(NTRK3)
TGE: 112629228(NTRK3)
RRO: 104661599(NTRK3)
RBB: 108535790(NTRK3)
TFN: 117070256(NTRK3)
PTEH: 111522905(NTRK3)
CJC: 100413191(NTRK3)
SBQ: 101048153(NTRK3)
CSYR: 103254803(NTRK3)
MMUR: 105884701(NTRK3)
OGA: 100951544(NTRK3)
MMU: 18213(Ntrk3)
MCAL: 110297619(Ntrk3)
MPAH: 110323509(Ntrk3)
RNO: 29613(Ntrk3)
MCOC: 116102418(Ntrk3)
MUN: 110552446(Ntrk3)
CGE: 100755800(Ntrk3)
PLEU: 114699869(Ntrk3)
NGI: 103749925(Ntrk3)
HGL: 101723255(Ntrk3)
CPOC: 100731493(Ntrk3)
CCAN: 109678568(Ntrk3)
DORD: 105982398(Ntrk3)
DSP: 122123968(Ntrk3)
OCU: 103346142(NTRK3) 103346972
OPI: 101523461(NTRK3)
TUP: 102495274(NTRK3)
CFA: 100856261(NTRK3)
VVP: 112921879(NTRK3)
VLG: 121489161(NTRK3)
AML: 100472259(NTRK3)
UMR: 103660166(NTRK3)
UAH: 113263672(NTRK3)
UAR: 123802425(NTRK3)
ELK: 111152589
LLV: 125104730
MPUF: 101676243(NTRK3)
ORO: 101382416(NTRK3)
EJU: 114223284(NTRK3)
ZCA: 113909410(NTRK3)
MLX: 118023033(NTRK3)
FCA: 101085548(NTRK3)
PYU: 121042420(NTRK3)
PBG: 122468252(NTRK3)
PTG: 102965762(NTRK3)
PPAD: 109273406(NTRK3)
AJU: 106965856(NTRK3)
HHV: 120220033(NTRK3)
BTA: 539126(NTRK3)
BOM: 102266155(NTRK3)
BIU: 109575138
BBUB: 102401892(NTRK3)
CHX: 102185689(NTRK3)
OAS: 101121631(NTRK3)
ODA: 120875661(NTRK3)
CCAD: 122455321(NTRK3)
SSC: 397511(NTRK3)
CFR: 102504225(NTRK3)
CBAI: 105075180(NTRK3)
CDK: 105085458(NTRK3)
VPC: 102530056(NTRK3)
BACU: 103011612(NTRK3)
LVE: 103073064(NTRK3)
OOR: 101290435(NTRK3)
DLE: 111169328(NTRK3)
PCAD: 102992259(NTRK3)
PSIU: 116749443(NTRK3)
ECB: 100069852(NTRK3)
EPZ: 103555692(NTRK3)
EAI: 106832014(NTRK3)
MYB: 102248845(NTRK3)
MYD: 102761142(NTRK3)
MMYO: 118679277(NTRK3)
MLF: 102433411(NTRK3) 102443290
MNA: 107527826(NTRK3)
PKL: 118704336(NTRK3)
HAI: 109394772(NTRK3)
DRO: 112305916(NTRK3)
SHON: 118991988(NTRK3)
AJM: 119049115(NTRK3)
PDIC: 114488572(NTRK3)
PHAS: 123809782(NTRK3)
MMF: 118640961(NTRK3)
RFQ: 117018962(NTRK3)
PALE: 102879798(NTRK3)
PGIG: 120599263(NTRK3)
PVP: 105306725
RAY: 107514177(NTRK3)
MJV: 108402158(NTRK3)
TOD: 119244304(NTRK3)
SARA: 101544461(NTRK3)
LAV: 100676434(NTRK3)
TMU: 101346626
DNM: 101435243(NTRK3)
MDO: 100013667(NTRK3)
GAS: 123238091(NTRK3)
SHR: 100926082(NTRK3)
PCW: 110193073(NTRK3)
OAA: 100078146(NTRK3)
GGA: 396081(NTRK3)
PCOC: 116225399(NTRK3)
MGP: 100546817(NTRK3)
CJO: 107318811(NTRK3)
NMEL: 110403788(NTRK3)
APLA: 101790659(NTRK3)
ACYG: 106036476(NTRK3)
AFUL: 116493605(NTRK3)
TGU: 100227403(NTRK3)
LSR: 110470597(NTRK3)
SCAN: 103816080(NTRK3)
PMOA: 120509033(NTRK3)
OTC: 121343616(NTRK3)
PRUF: 121354547(NTRK3)
GFR: 102035445(NTRK3)
FAB: 101806756(NTRK3)
PHI: 102100349(NTRK3)
PMAJ: 107209364(NTRK3)
CCAE: