KEGG   ORTHOLOGY: K04386
Entry
K04386                      KO                                     
Symbol
IL1R1, CD121a
Name
interleukin 1 receptor type I
Pathway
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04064  NF-kappa B signaling pathway
map04380  Osteoclast differentiation
map04640  Hematopoietic cell lineage
map04659  Th17 cell differentiation
map04750  Inflammatory mediator regulation of TRP channels
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05146  Amoebiasis
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05418  Fluid shear stress and atherosclerosis
Disease
H01492  Systemic sclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04064 NF-kappa B signaling pathway
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04659 Th17 cell differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   05163 Human cytomegalovirus infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   05131 Shigellosis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
   04090 CD molecules
    K04386  IL1R1, CD121a; interleukin 1 receptor type I
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL1 receptor family
   K04386  IL1R1, CD121a; interleukin 1 receptor type I
CD molecules [BR:ko04090]
 Proteins
  K04386  CD121a, IL1R1; interleukin 1 receptor, type I
Other DBs
GO: 0004909
Genes
HSA: 3554(IL1R1)
PTR: 459460(IL1R1)
PPS: 100972617(IL1R1)
GGO: 101133600(IL1R1)
PON: 100172810(IL1R1)
NLE: 100586658(IL1R1)
MCC: 711726(IL1R1)
MCF: 102146317(IL1R1)
MTHB: 126934234
CSAB: 103241149(IL1R1)
CATY: 105583647(IL1R1)
PANU: 101003909(IL1R1)
TGE: 112604908(IL1R1)
RRO: 104680311(IL1R1)
RBB: 108524091(IL1R1)
TFN: 117062283(IL1R1)
PTEH: 111542169(IL1R1)
CANG: 105522167(IL1R1)
CJC: 100393945(IL1R1)
SBQ: 101031937(IL1R1)
CSYR: 103260528(IL1R1)
MMUR: 105857833(IL1R1)
LCAT: 123637267(IL1R1)
PCOQ: 105808263(IL1R1)
OGA: 100959140(IL1R1)
MMU: 16177(Il1r1)
MCAL: 110293878(Il1r1)
MPAH: 110321407(Il1r1)
RNO: 25663(Il1r1)
MCOC: 116088348(Il1r1)
CGE: 100758740(Il1r1)
MAUA: 101823176(Il1r1)
PLEU: 114690812(Il1r1)
MORG: 121450585(Il1r1)
MFOT: 126496981
AAMP: 119822271(Il1r1)
NGI: 103744180(Il1r1)
HGL: 101711273(Il1r1)
CPOC: 100724206(Il1r1)
CCAN: 109682273(Il1r1)
DORD: 105988260(Il1r1)
DSP: 122121295(Il1r1)
NCAR: 124962993
OCU: 100352905
OPI: 101519459(IL1R1)
TUP: 102492414(IL1R1)
GVR: 103610948(IL1R1)
CFA: 481328(IL1R1)
CLUD: 112669932(IL1R1)
VVP: 112915144(IL1R1)
VLG: 121490366(IL1R1)
AML: 100472991(IL1R1)
UMR: 103670641(IL1R1)
UAH: 113247336(IL1R1)
UAR: 123775960(IL1R1)
ELK: 111155931
LLV: 125108912
MPUF: 101670524(IL1R1)
ORO: 101381751(IL1R1)
EJU: 114209829(IL1R1)
ZCA: 113938587(IL1R1)
MLX: 118008270(IL1R1)
NSU: 110572074(IL1R1)
LWW: 102741586(IL1R1)
FCA: 101080705(IL1R1)
PYU: 121016438(IL1R1)
PBG: 122496688(IL1R1)
LRUF: 124502907
PTG: 102958342(IL1R1)
PPAD: 109254564(IL1R1)
AJU: 106968747(IL1R1)
HHV: 120245902(IL1R1)
BTA: 515640(IL1R1)
BOM: 102271047(IL1R1)
BIU: 109565502(IL1R1)
BBUB: 102402346(IL1R1)
BBIS: 104980851(IL1R1)
CHX: 102187231(IL1R1)
OAS: 101103054(IL1R1)
ODA: 120883612(IL1R1)
CCAD: 122441438(IL1R1)
SSC: 100626904(IL1R1)
CFR: 102503597(IL1R1)
CBAI: 105072217(IL1R1)
CDK: 105099109(IL1R1)
VPC: 102544667(IL1R1)
BACU: 102998234(IL1R1)
LVE: 103084028
OOR: 101277609(IL1R1)
DLE: 111187389(IL1R1)
PCAD: 102973768(IL1R1)
PSIU: 116763886(IL1R1)
ECB: 100009699(IL1R1)
EPZ: 103563183(IL1R1)
EAI: 106839400(IL1R1)
MYB: 102238676(IL1R1)
MYD: 102775132(IL1R1)
MMYO: 118679042(IL1R1)
MLF: 102437031
MNA: 107532712(IL1R1)
PKL: 118727943(IL1R1)
HAI: 109395478(IL1R1)
DRO: 112315147(IL1R1)
SHON: 118994653(IL1R1)
AJM: 119047918(IL1R1) 119047921
PDIC: 114499425(IL1R1)
PHAS: 123811594(IL1R1)
MMF: 118631025(IL1R1)
RFQ: 117033297(IL1R1)
PALE: 102884439(IL1R1)
PGIG: 120584449(IL1R1)
PVP: 105298727(IL1R1)
RAY: 107498102(IL1R1)
MJV: 108404707(IL1R1)
TOD: 119259279(IL1R1)
SARA: 101537237(IL1R1)
LAV: 100657834(IL1R1)
TMU: 101358013
ETF: 101660872(IL1R1)
DNM: 101447218(IL1R1)
MDO: 100017751(IL1R1)
GAS: 123241763(IL1R1)
SHR: 100913514
PCW: 110209396(IL1R1)
OAA: 100084073(IL1R1)
GGA: 396481(IL1R1)
PCOC: 116236528
MGP: 100540676
CJO: 107306834
NMEL: 110406790
APLA: 101794055 101795572(IL1RL1)
ACYG: 106041672
AFUL: 116492687
TGU: 100220817(IL1R1)
LSR: 110474740
SCAN: 103812363
PMOA: 120504582
OTC: 121343206
PRUF: 121354092
GFR: 102040488(IL1R1)
FAB: 101815105(IL1R1)
PHI: 102106217(IL1R1)
PMAJ: 107210317
CCAE: 111942272
CCW: 104686063(IL1R1)
CBRC: 103617523(IL1R1)
ETL: 114068702
ZAB: 102065213(IL1R1)
ACHL: 103810120
FPG: 101912007
FCH: 102060155
CLV: 102097520(IL1R1)
EGZ: 104126373(IL1RL1) 104126375
NNI: 104019340
PLET: 104626063
PCRI: 104025350(IL1R1)
PCAO: 104039648(IL1RL2)
ACUN: 113484904(IL1R1)
TALA: 104356295
PADL: 103918827 103918873(IL1RL1)
AFOR: 103896288
ACHC: 115334517(IL1R1)
HALD: 104322108
HLE: 104836920
AGEN: 126053030
GCL: 127013124
CCRI: 104168439
CSTI: 104564189
CMAC: 104473405
MUI: 104534625(IL1R1)
FGA: 104080987(IL1RL2)
GSTE: 104250733(IL1RL2)
LDI: 104349371
OHA: 104329456
NNT: 104401645(IL1R1)
DPUB: 104310045
PGUU: 104458055
ACAR: 104520472
CPEA: 104389002
AVIT: 104267686
CVF: 104284747
CUCA: 104056642
TEO: 104370625
BRHI: 104498527
AAM: 106494064(IL1R1)
AROW: 112966181
NPD: 112954964
TGT: 104578347
DNE: 112984961
SCAM: 104138636
ASN: 102377912
AMJ: 102558564(IL1R1)
GGN: 109303109 109303181(IL1RL2)
PSS: 102463929
CMY: 102937532
CPIC: 101942308
CABI: 116832859(IL1R1) 116832861
ACS: 100553004
PVT: 110090152
PBI: 112542425
PMUR: 107288201
PMUA: 114596401(IL1R1)
ZVI: 118084996
GJA: 107110211
XTR: 100491546(il1r1)
RTEM: 120926475(IL1R1)
BGAR: 122931522 122931549(IL1R1)
DRE: 799204(zmp:0000000936) 799279
PPRM: 120479173(zmp:0000000936) 120479174
SMEO: 124377808 124382274 124383179(zmp:0000000936)
TFD: 113646269 113646273(zmp:0000000936) 113648674
LCO: 104928679
CGOB: 115026861
ELY: 117251338
EFO: 125899698
PLEP: 121949002
SLUC: 116063738
ECRA: 117952382
ESP: 116697890
PFLV: 114563795
GAT: 120833889
PPUG: 119229350
MSAM: 119904455
CUD: 121522535
ALAT: 119025790
MZE: 101470103
ONL: 100702660
OAU: 116314797
OLA: 101157257
OML: 112155212
XMA: 102235704
XCO: 114148728
XHE: 116723605
PFOR: 103134846
PLAI: 106936431
PMEI: 106926663
GAF: 122839835
CVG: 107087363
CTUL: 119795929
GMU: 124871075
NFU: 107389426
NWH: 119419396
AOCE: 111563964
MCEP: 125018280
CSEM: 103391984
SSEN: 122763674
HHIP: 117755312
HSP: 118119887
XGL: 120801566
HCQ: 109522385
BPEC: 110169112
MALB: 109968094
BSPL: 114847513
STRU: 115161013
OTW: 112231472 112234773 112239331 112239342(zmp:0000000936)
OMY: 100136037(il-1r1) 110502091 110520326(zmp:0000000936)
OGO: 124044040
ONE: 115111503
SNH: 120057936
CCLU: 121536314
AANG: 118224403
ARUT: 117405220
CMK: 103172493
HAME: 121875633
 » show all
Reference
PMID:2532321
  Authors
Chua AO, Gubler U
  Title
Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.
  Journal
Nucleic Acids Res 17:10114 (1989)
DOI:10.1093/nar/17.23.10114
  Sequence
[hsa:3554]
Reference
  Authors
Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, Dower SK
  Title
Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
  Journal
J Biol Chem 275:4670-8 (2000)
DOI:10.1074/jbc.275.7.4670
LinkDB

KEGG   ORTHOLOGY: K04723
Entry
K04723                      KO                                     
Symbol
IL1RAP
Name
interleukin 1 receptor accessory protein
Pathway
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04659  Th17 cell differentiation
map04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04723  IL1RAP; interleukin 1 receptor accessory protein
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04723  IL1RAP; interleukin 1 receptor accessory protein
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04723  IL1RAP; interleukin 1 receptor accessory protein
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04723  IL1RAP; interleukin 1 receptor accessory protein
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K04723  IL1RAP; interleukin 1 receptor accessory protein
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL1 receptor family
   K04723  IL1RAP; interleukin 1 receptor accessory protein
Genes
HSA: 3556(IL1RAP)
PTR: 460935(IL1RAP)
PPS: 100990776(IL1RAP)
GGO: 101126854(IL1RAP)
PON: 100172432(IL1RAP)
NLE: 100580986(IL1RAP)
MCC: 574387(IL1RAP)
MCF: 102133222
MTHB: 126948023
CSAB: 103241903(IL1RAP)
CATY: 105575191(IL1RAP)
PANU: 100998471(IL1RAP)
TGE: 112619670(IL1RAP)
RRO: 104680048(IL1RAP)
RBB: 108530480(IL1RAP)
TFN: 117084381(IL1RAP)
PTEH: 111544285(IL1RAP)
CANG: 105525839(IL1RAP)
CJC: 100392625(IL1RAP)
SBQ: 101040233(IL1RAP)
CSYR: 103270923(IL1RAP)
MMUR: 105860441(IL1RAP)
LCAT: 123630388
PCOQ: 105808785(IL1RAP)
OGA: 100952305(IL1RAP)
MMU: 16180(Il1rap)
MCAL: 110311552(Il1rap)
MPAH: 110329561(Il1rap)
RNO: 25466(Il1rap)
MCOC: 116085769(Il1rap)
MUN: 110541070(Il1rap)
CGE: 100771447(Il1rap)
MAUA: 101842609
PLEU: 114697095
MORG: 121464952
MFOT: 126512301
AAMP: 119825053
NGI: 103739339(Il1rap)
HGL: 101707386(Il1rap)
CPOC: 100714704(Il1rap)
DORD: 105988011(Il1rap)
DSP: 122098975
NCAR: 124992826
OCU: 100341281
OPI: 101534836
TUP: 102486497(IL1RAP)
GVR: 103599674(IL1RAP)
CFA: 488126(IL1RAP)
CLUD: 112645830
VVP: 112926311(IL1RAP)
AML: 100472192(IL1RAP)
UMR: 103676019(IL1RAP)
UAH: 113253525(IL1RAP)
UAR: 123801281
ELK: 111151093
LLV: 125102154
MPUF: 101683223(IL1RAP)
ORO: 101372824(IL1RAP)
EJU: 114207120(IL1RAP)
ZCA: 113917532
MLX: 118006943(IL1RAP)
NSU: 110582733
LWW: 102741894
FCA: 101094125(IL1RAP)
PYU: 121034154
PBG: 122491608
LRUF: 124526888
PTG: 102949407(IL1RAP)
PPAD: 109275315(IL1RAP)
AJU: 106968030(IL1RAP)
HHV: 120233109
BTA: 539334(IL1RAP)
BOM: 102285629(IL1RAP)
BIU: 109556715(IL1RAP)
BBUB: 102396581
BBIS: 104996445(IL1RAP)
CHX: 102188711(IL1RAP)
OAS: 101108354
ODA: 120872697
CCAD: 122444794
SSC: 100628318(IL1RAP)
CFR: 102517398(IL1RAP)
CBAI: 105072355(IL1RAP)
CDK: 105097548(IL1RAP)
VPC: 102545266(IL1RAP)
BACU: 103002906(IL1RAP)
LVE: 103085088(IL1RAP)
OOR: 101285541(IL1RAP)
DLE: 111172703(IL1RAP)
PCAD: 102994287(IL1RAP)
PSIU: 116753487(IL1RAP)
ECB: 100068726(IL1RAP)
EPZ: 103564852(IL1RAP)
EAI: 106832560
MYB: 102239162 102247506(IL1RAP)
MYD: 102771155(IL1RAP)
MMYO: 118677195
MLF: 102421835(IL1RAP)
MNA: 107527297(IL1RAP)
PKL: 118722686
HAI: 109371236(IL1RAP)
DRO: 112301004(IL1RAP)
SHON: 118982222
AJM: 119039100
PDIC: 114490986
PHAS: 123827290
MMF: 118617067
RFQ: 117036159(IL1RAP)
PALE: 102892819(IL1RAP)
PGIG: 120593046
PVP: 105306481(IL1RAP)
RAY: 107505912(IL1RAP)
MJV: 108384285(IL1RAP)
TOD: 119257393
SARA: 101558845(IL1RAP)
LAV: 100666654(IL1RAP)
TMU: 101349040
ETF: 101662924
DNM: 101442775(IL1RAP)
MDO: 100016835(IL1RAP)
GAS: 123242010
SHR: 100933140(IL1RAP)
PCW: 110193129(IL1RAP)
OAA: 100081686
GGA: 424908(IL1RAP)
PCOC: 116235339(IL1RAP)
MGP: 100549067(IL1RAP)
CJO: 107318248(IL1RAP)
NMEL: 110398225
APLA: 101795740(IL1RAP)
ACYG: 106047606
AFUL: 116492383(IL1RAP)
TGU: 100232686(IL1RAP)
LSR: 110473903(IL1RAP)
SCAN: 103815624(IL1RAP)
PMOA: 120504323
OTC: 121336666
PRUF: 121353838
GFR: 102034831(IL1RAP)
FAB: 101816129(IL1RAP)
PHI: 102099952(IL1RAP)
PMAJ: 107208944(IL1RAP)
CCAE: 111933457(IL1RAP)
CCW: 104687925
CBRC: 103625212(IL1RAP)
ETL: 114057591(IL1RAP)
ZAB: 102075069(IL1RAP)
ACHL: 103809529(IL1RAP)
FPG: 101913890(IL1RAP)
FCH: 102059926(IL1RAP)
CLV: 102092020(IL1RAP)
EGZ: 104123380(IL1RAP)
NNI: 104015670(IL1RAP)
PLET: 104618397(IL1RAP)
PCRI: 104028254(IL1RAP)
PCAO: 104045135(IL1RAP)
ACUN: 113483509(IL1RAP)
TALA: 104361937
PADL: 103925383(IL1RAP)
AFOR: 103901458(IL1RAP)
ACHC: 115347332
HALD: 104324400(IL1RAP)
HLE: 104835187(IL1RAP)
AGEN: 126039589
GCL: 127020238
CSTI: 104557026(IL1RAP)
EHS: 104505863(IL1RAP)
CMAC: 104480365(IL1RAP)
MUI: 104534433(IL1RAP)
FGA: 104081140(IL1RAP)
GSTE: 104257084
LDI: 104348206(IL1RAP)
MNB: 103773940(IL1RAP)
OHA: 104326853(IL1RAP)
NNT: 104403920(IL1RAP)
DPUB: 104300719(IL1RAP)
PGUU: 104468762(IL1RAP)
ACAR: 104532213(IL1RAP)
CPEA: 104390724(IL1RAP)
AVIT: 104274619(IL1RAP)
CVF: 104285029(IL1RAP)
CUCA: 104063466(IL1RAP)
TEO: 104378275(IL1RAP)
BRHI: 104494043(IL1RAP)
AAM: 106498193(IL1RAP)
AROW: 112968552(IL1RAP)
NPD: 112952527(IL1RAP)
TGT: 104565752(IL1RAP)
DNE: 112979369(IL1RAP)
SCAM: 104148795(IL1RAP)
ASN: 102387107(IL1RAP)
AMJ: 102567774(IL1RAP)
CPOO: 109308553(IL1RAP)
GGN: 109288108(IL1RAP)
PSS: 102445541(IL1RAP)
CMY: 102940652
CPIC: 101933375
TST: 117882923(IL1RAP)
CABI: 116823029(IL1RAP)
MRV: 120372292
ACS: 100563166(il1rap)
PVT: 110085948(IL1RAP)
SUND: 121925723
PMUR: 107299035(IL1RAP)
CTIG: 120319821
TSR: 106538453
PGUT: 117669824(IL1RAP)
VKO: 123036789
PMUA: 114598124(IL1RAP)
ZVI: 118093688(IL1RAP)
GJA: 107113540(IL1RAP)
STOW: 125438223
XLA: 108716971(il1rap.L) 108718047(il1rap.S)
XTR: 100216065(il1rap)
NPR: 108804591(IL1RAP)
RTEM: 120936855
BBUF: 120997979
BGAR: 122934099
DRE: 100331351(il1rap)
PPRM: 120470682
MAMB: 125248378
IPU: 108277591
PHYP: 113544533
SMEO: 124394568
TFD: 113637881
AMEX: 103022553(il1rap)
EEE: 113588549(il1rap)
TRU: 105418371(il1rap)
LCO: 104939698(il1rap)
ELY: 117259255
EFO: 125889528
PLEP: 121942823
PFLV: 114553249(il1rap)
GAT: 120823055
PPUG: 119227817
MSAM: 119882583
CUD: 121522567
ALAT: 119010026
ONL: 100703991(il1rap) 102075875
OLA: 101168842(il1rap)
OML: 112149688
XMA: 102222389(il1rap)
XCO: 114161721(il1rap)
XHE: 116737685(il1rap)
PRET: 103460066
PFOR: 103150889(il1rap)
PLAI: 106962667(il1rap)
PMEI: 106933700(il1rap)
GAF: 122832755
CVG: 107086872(il1rap)
CTUL: 119791542
GMU: 124884583
NFU: 107379882
KMR: 108229411
ALIM: 106511885(il1rap) 106536182
NWH: 119410987
AOCE: 111586849
MCEP: 125013951
CSEM: 103378400(il1rap)
POV: 109644732
SSEN: 122773123
HHIP: 117772455
HSP: 118106494
LCF: 108874422
SDU: 111216885(il1rap)
SLAL: 111663357(il1rap)
XGL: 120792029
HCQ: 109514266
BPEC: 110162875(il1rap)
MALB: 109973263(il1rap)
BSPL: 114868316
SASA: 100136401(il-1racp)
STRU: 115205813
OTW: 112241940
OMY: 110490048
OGO: 123994824
ONE: 115106766
SALP: 111960635
SNH: 120028321
ELS: 105006651
SFM: 108922149(il1rap)
PKI: 111843097(il1rap)
AANG: 118210208
LOC: 102695221(il1rap)
PSEX: 120537032
LCM: 102354139(IL1RAP)
CMK: 103187976
RTP: 109913741(il1rap)
SPU: 764816
APLC: 110981010
CSEC: 111866813
 » show all
Reference
PMID:9371760
  Authors
Huang J, Gao X, Li S, Cao Z
  Title
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.
  Journal
Proc Natl Acad Sci U S A 94:12829-32 (1997)
DOI:10.1073/pnas.94.24.12829
  Sequence
[hsa:3556]
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