KEGG ORTHOLOGY: K04432

ORTHOLOGY: K04432

Entry

K04432                      KO

Symbol

MAP2K3, MKK3

Name

mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04015

Rap1 signaling pathway

map04218

Cellular senescence

map04620

Toll-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04664

Fc epsilon RI signaling pathway

map04668

TNF signaling pathway

map04714

Thermogenesis

map04750

Inflammatory mediator regulation of TRP channels

map04912

GnRH signaling pathway

map04935

Growth hormone synthesis, secretion and action

map04936

Alcoholic liver disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05132

Salmonella infection

map05135

Yersinia infection

map05145

Toxoplasmosis

map05161

Hepatitis B

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04013 MAPK signaling pathway - fly
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04015 Rap1 signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04668 TNF signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04624 Toll and Imd signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04664 Fc epsilon RI signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   04935 Growth hormone synthesis, secretion and action
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05161 Hepatitis B
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05169 Epstein-Barr virus infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05135 Yersinia infection
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE7 family
   K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3

Other DBs

GO:

0004708

Genes

HSA:	5606(MAP2K3)

PTR:

107972404

PPS:

100975020

GGO:	101145420(MAP2K3)

PON:	100457536(MAP2K3)

PPYG:

129017412(MAP2K3)

NLE:	100588703(MAP2K3)

HMH:	116483006(MAP2K3)

SSYN:

129461583(MAP2K3)

MCC:	705195(MAP2K3)

MCF:	102116823(MAP2K3)

MTHB:

126939044

MNI:	105493311(MAP2K3)

CSAB:

103242535(MAP2K3)

CATY:

105593750(MAP2K3)

PANU:

101012583(MAP2K3)

TGE:	112608997(MAP2K3)

MLEU:

105554627(MAP2K3)

RRO:	104678467(MAP2K3)

RBB:	108521513(MAP2K3)

TFN:	117089741(MAP2K3)

PTEH:

111528301(MAP2K3)

CANG:

105526517(MAP2K3)

CJC:	100398593(MAP2K3)

SBQ:	101034633(MAP2K3)

CIMI:

108290685(MAP2K3)

ANAN:

105723626(MAP2K3)

CSYR:

103264569(MAP2K3)

MMUR:

105856318(MAP2K3)

LCAT:

123650554(MAP2K3)

ERUF:

138391846(MAP2K3)

PCOQ:

105816099(MAP2K3)

OGA:	100955929(MAP2K3)

MMU:	26397(Map2k3)

MCAL:

110304977(Map2k3)

MPAH:

110331197(Map2k3)

RNO:	303200(Map2k3)

MCOC:

116077938(Map2k3)

ANU:	117710465(Map2k3)

ASYL:

127695182(Map2k3)

MUN:	110561677(Map2k3)

CGE:	100756793(Map2k3)

MAUA:

101838194(Map2k3)

PROB:

127219179(Map2k3)

PLEU:

114683276(Map2k3)

PMAV:

102910626(Map2k3)

MORG:

121456403(Map2k3)

MFOT:

126514653

AAMP:

119813155(Map2k3)

CNL:	130878137(Map2k3)

NGI:	103724822(Map2k3)

HGL:	101718318(Map2k3)

CPOC:

100726100(Map2k3)

CCAN:

109692052(Map2k3)

DORD:

105985703(Map2k3)

DSP:	122103259(Map2k3)

DMER:

138830783(Map2k3)

PLOP:

125366093(Map2k3)

NCAR:

124980599

MMMA:

107157178

ITI:	101960440(Map2k3)

OCU:

100339953

OPI:	101517788(MAP2K3)

OCZ:	121167549 121170037

TUP:	102499419(MAP2K3)

GVR:	103599172(MAP2K3)

CFA:	489547(MAP2K3)

CLUD:

112647216(MAP2K3)

VVP:	112924977(MAP2K3)

VLG:	121499935(MAP2K3)

NPO:	129497110(MAP2K3)

AML:	100476678(MAP2K3)

UMR:	103658475(MAP2K3)

UAH:	113271318(MAP2K3)

UAR:	123779716(MAP2K3)

ELK:

111139240

LLV:

125087473

MPUF:

101679855(MAP2K3)

MNP:	132004567(MAP2K3)

MLK:	131816095(MAP2K3)

NVS:	122906843(MAP2K3)

ORO:	101378651(MAP2K3)

EJU:	114198178(MAP2K3)

ZCA:	113939775(MAP2K3)

MLX:	118000167(MAP2K3)

NSU:	110584435(MAP2K3)

LWW:	102725552(MAP2K3)

FCA:	101082274(MAP2K3)

PYU:	121015779(MAP2K3)

PCOO:

112857077(MAP2K3)

PBG:	122485071(MAP2K3)

PVIV:

125151879(MAP2K3)

LRUF:

124519494

LGF:	123603147(MAP2K3)

AJU:

106981449

PTG:	102949954(MAP2K3)

PPAD:

109245742(MAP2K3)

PUC:

125926929

PLEZ:

122206095(MAP2K3)

HHV:	120228759(MAP2K3)

BTA:	516039(MAP2K3)

BOM:	102267773(MAP2K3)

BIU:	109574182(MAP2K3)

BBUB:

102391709(MAP2K3)

BKE:	129649166(MAP2K3)

BBIS:

104990647(MAP2K3)

CHX:	102173967(MAP2K3)

OAS:	101122959(MAP2K3)

BTAX:

128064641(MAP2K3)

CSUM:

138083023(MAP2K3)

ODA:	120867361(MAP2K3)

CCAD:

122443696(MAP2K3)

MREE:

136149545(MAP2K3)

OVR:	110151006(MAP2K3)

MBEZ:

129544242(MAP2K3)

SSC:	110256149(MAP2K3)

CFR:	102523780(MAP2K3)

CBAI:

105084150(MAP2K3)

CDK:	105100607(MAP2K3)

VPC:	102530139(MAP2K3)

BACU:

103019100(MAP2K3)

BMUS:

118886770(MAP2K3)

LVE:	103091611(MAP2K3)

OOR:	101275666(MAP2K3)

LALB:

132512009(MAP2K3)

GMF:	115855723(MAP2K3)

DDP:	132415388(MAP2K3)

DLE:	111167700(MAP2K3)

PCAD:

102978047(MAP2K3)

PSIU:

116745655(MAP2K3)

PPHC:

136138039(MAP2K3)

NASI:

112404892(MAP2K3)

ECB:	100053481(MAP2K3)

EPZ:	103563092(MAP2K3)

EAI:	106825518(MAP2K3)

MYB:	102259712(MAP2K3)

MYD:	102765923(MAP2K3)

MMYO:

118662418

MDT:	132217892(MAP2K3)

MYUM:

138995131(MAP2K3)

PKL:	118721075(MAP2K3)

EFUS:

103303990(MAP2K3)

MNA:	107542219(MAP2K3)

DRO:	112308621(MAP2K3)

SHON:

119002731(MAP2K3)

AJM:	119062274(MAP2K3)

PDIC:

114515272(MAP2K3)

PHAS:

123809430(MAP2K3)

MMF:	118641294(MAP2K3)

PPAM:

129068738(MAP2K3)

HAI:	109390353(MAP2K3)

RFQ:	117013305(MAP2K3) 117018399

PALE:

102886389(MAP2K3)

PGIG:

120589895(MAP2K3)

PVP:	105304165(MAP2K3)

RAY:	107506757(MAP2K3)

MJV:	108392844(MAP2K3)

TOD:	119230399(MAP2K3)

SARA:

101555912(MAP2K3)

SFUM:

130043804(MAP2K3)

SETR:

126013729(MAP2K3)

LAV:	100675607(MAP2K3)

TMU:

101355711

ETF:	101639675(MAP2K3)

MDO:	100016872(MAP2K3)

GAS:	123233796(MAP2K3)

SHR:	100925586(MAP2K3)

AFZ:

127563289

PCW:	110223168(MAP2K3)

TVP:	118833764(MAP2K3)

PBRV:

138158622(MAP2K3)

MLAO:

141501424(MAP2K3)

OAA:	100080734(MAP2K3)

TACU:

119941951(MAP2K3)

GGA:	416496(MAP2K3)

PCOC:

116237354(MAP2K3)

MGP:	100542290(MAP2K3)

CJO:	107320760(MAP2K3)

TPAI:

128079133(MAP2K3)

LMUT:

125700804(MAP2K3)

NMEL:

110405901(MAP2K3)

APLA:

101803371(MAP2K3)

AACU:

137864684(MAP2K3)

ACYG:

106032094(MAP2K3)

CATA:

118256504(MAP2K3)

AFUL:

116495505(MAP2K3)

TGU:	100229860(MAP2K3)

LSR:	110481212(MAP2K3)

SCAN:

103817610(MAP2K3)

PMOA:

120513145(MAP2K3)

OTC:	121334535(MAP2K3)

PRUF:

121350851(MAP2K3)

ATRC:

139598014(MAP2K3)

GFR:	102039295(MAP2K3)

FAB:	101809415(MAP2K3)

OMA:	130259290(MAP2K3)

PHI:	102109535(MAP2K3)

PMAJ:

107211348(MAP2K3)

CCAE:

111936127(MAP2K3)

CCW:	104684789(MAP2K3)

CBRC:

103615404(MAP2K3)

ACOE:

138118731(MAP2K3)

ETL:	114060189(MAP2K3)

ZAB:	102069824(MAP2K3)

ZLE:	135454237(MAP2K3)

ACHL:

103807200(MAP2K3)

SVG:	106849913(MAP2K3)

MMEA:

130575698(MAP2K3)

HRT:	120759791(MAP2K3)

SATI:

136367943(MAP2K3)

CFAI:

136297823(MAP2K3)

CCIC:

134050683(MAP2K3)

FPG:	101919170(MAP2K3)

FCH:	102052703(MAP2K3)

CCRI:

104169564

NNT:	104408256(MAP2K3)

SHAB:

115607143

ACUN:

113485588(MAP2K3)

SURA:

141950684(MAP2K3)

TALA:

104357596(MAP2K3)

ACHC:

115335899(MAP2K3)

HALD:

104323060(MAP2K3)

HLE:	104833592(MAP2K3)

AGEN:

126034069

HHAR:

128134676(MAP2K3)

BBUT:

142045335(MAP2K3)

GCL:

127022624

CSTI:

104557393(MAP2K3)

LDI:	104342452(MAP2K3)

MNB:

103769299

DPUB:

104296953(MAP2K3)

PPUS:

135180823(MAP2K3)

AVIT:

104270947(MAP2K3)

BRHI:

104496252(MAP2K3)

EGZ:

104132608

NNI:	104015109(MAP2K3)

PCRI:

104033009

PCAO:

104043088

PADL:

103918788(MAP2K3)

AFOR:

103904894(MAP2K3)

FGA:	104081195(MAP2K3)

CBOR:

142089218(MAP2K3)

GSTE:

104262007(MAP2K3)

CBOY:

140658961(MAP2K3)

MAME:

142415890(MAP2K3)

CLV:	102085143(MAP2K3)

CNIC:

135994314(MAP2K3)

MUI:	104544376(MAP2K3)

PGUU:

104469010(MAP2K3)

PLET:

104626208(MAP2K3)

EHS:

104511600

CMAC:

104482374(MAP2K3)

CUCA:

104062506(MAP2K3)

TEO:	104378316(MAP2K3)

BREG:

104636685(MAP2K3)

GAME:

129213345(MAP2K3)

OHA:	104335669(MAP2K3)

ACAR:

104522657(MAP2K3)

CPEA:

104385265(MAP2K3)

CVF:	104290138(MAP2K3)

RTD:	128913932(MAP2K3)

CRID:

134519328(MAP2K3)

LMIC:

141747407(MAP2K3)

NARQ:

141471690(MAP2K3)

AAM:

106486833

AROW:

112974370

NPD:	112960040(MAP2K3)

TGT:

104573266

DNE:	112980388(MAP2K3)

SCAM:

104150824(MAP2K3)

ASN:	102383945(MAP2K3)

AMJ:	102566638(MAP2K3)

CPOO:

109314684(MAP2K3)

GGN:	109294332(MAP2K3)

PSS:	102454019(MAP2K3)

CIZ:	142021603(MAP2K3)

CMY:	102939584(MAP2K3)

CCAY:

125643689(MAP2K3)

LKP:	140918137(MAP2K3)

NDS:	141994778(MAP2K3)

DCC:	119862777(MAP2K3)

CPIC:

101936976(MAP2K3)

TST:	117883675(MAP2K3)

CABI:

116826312(MAP2K3)

MRV:	120373319(MAP2K3)

ACS:	100561588(map2k3)

ASAO:

132780018

PVT:	110087206(MAP2K3)

SUND:

121914162(MAP2K3)

PBI:	103065723(MAP2K3)

CTIG:

120315718(MAP2K3)

PGUT:

117676778(MAP2K3)

PCAE:

139325521(MAP2K3)

APRI:

131185369(MAP2K3)

PTEX:

113438784(MAP2K3)

NSS:	113423604(MAP2K3)

VKO:	123024965(MAP2K3)

PMUA:

114584096(MAP2K3)

PRAF:

128401910(MAP2K3)

ZVI:	118092693(MAP2K3)

HCG:	128336632(MAP2K3)

GJA:

107120519

STOW:

125431737(MAP2K3)

EMC:	129338683(MAP2K3)

PWL:	138261262(MAP2K3)

MUO:	115475373(MAP2K3)

GSH:	117345887(MAP2K3)

SFM:	108923933(map2k3) 108941534

PKI:	111836901 111847733(map2k3)

AANG:

118217046 118221019

AROT:

135243224 135248060

CCOG:

133114399 133122061

LOC:	102691753(map2k3)

PSPA:

121300746 121330854

ARUT:

117418403 117431675

PSEX:

120543271(map2k6)

LCM:	102351267(MAP2K3)

CMK:	103185143(map2k6)

RTP:	109922694(map2k6)

CPLA:

CPUN:

HOC:

SCAU:

STOZ:

LERI:

HAKA:

AJJ:

DME:	Dmel_CG12244(lic)

DER:

6551001

DSE:

6618621

DSI:	Dsimw501_GD24803(Dsim_lic)

DYA:	Dyak_GE17041

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16291

DAZ:

108619408

DNV:

108656880

DHE:

111593410

DVI:	6633830(lic)

CCAT:

101462574

BOD:

106620421

BDR:

105226954

RZE:	108356723 108366167 108371601

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135957415(lic)

GFS:	119631314 119643226

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003157

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108721780(lic)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139108994(Lic)

TLN:	139823171(Lic)

HST:

DQU:

CFO:

FEX:

PMEC:

138933674(Lic)

LHU:	105669425(lic)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141525035(Lic)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124220142(lic)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138138894(lic)

DPA:

109536941

ESIM:

136416843(lic)

EFOR:

136347424(lic)

SOY:

115884252

RFG:	143206631(lic)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200347

BANY:

112049528

MJU:	123871716 123871816

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137932105(lic)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110377974 135118475

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141428544 141428888(lic)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106688597(lic)

NLU:

111053498

LDA:	142330544(lic)

HVI:

124354306

MQU:

129001548

PHU:	Phum_PHUM372730

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138701834(lic)

SGRE:

126334719

BROR:

134534855

IEL:

124171180

HAMR:

139690904(lic)

FCD:

110850082

DPX:	DAPPUDRAFT_215363

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

HAME:

PCLA:

123756868(lic)

CQD:	128687666(lic)

PTRU:

ESN:

MNZ:

MRJ:

PORN:

139767241(lic)

HAZT:

108681958

OOT:	143039387(lic)

EAF:

111714880

LSM:	121116188(lic)

TCF:

131881174

DALB:

135914529(lic)

VDE:

111252897

VJA:	111268332 111270513

GOE:

DPTE:

DFR:

CSCU:

CVS:	136983745(lic)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

TSP:

HRO:	HELRODRAFT_89696

LGI:	LOTGIDRAFT_199455

PVUL:

PCAN:

LSAX:

BARL:

BGT:

HRF:

HRJ:

HASI:

137274219 137284227 137284343

HCRA:

CVN:

OED:

AIRR:

DPOL:

MAEA:

OBI:

OSN:

LJP:	135462194 135467706

LAK:	106155871 106162688

SMM:	Smp_073490

SHX:	MS3_00003185(MAP2K6_1)

EGL:

EGR_04099

TAD:	TRIADDRAFT_21026

» show all

Reference

PMID:8900184

Authors

Moriguchi T, Toyoshima F, Gotoh Y, Iwamatsu A, Irie K, Mori E, Kuroyanagi N, Hagiwara M, Matsumoto K, Nishida E

Title

Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2.

Journal

J Biol Chem 271:26981-8 (1996)
DOI:10.1074/jbc.271.43.26981

Sequence

[hsa:5606] [mmu:26397]

Reference

PMID:8622669

Authors

Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ

Title

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

Journal

Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247

Sequence

[hsa:5606]

LinkDB

ORTHOLOGY: K04430

Entry

K04430                      KO

Symbol

MAP2K4, MKK4

Name

mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]

Pathway

map04010

MAPK signaling pathway

map04012

ErbB signaling pathway

map04013

MAPK signaling pathway - fly

map04361

Axon regeneration

map04620

Toll-like receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04668

TNF signaling pathway

map04912

GnRH signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map04936

Alcoholic liver disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05132

Salmonella infection

map05135

Yersinia infection

map05142

Chagas disease

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05208

Chemical carcinogenesis - reactive oxygen species

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04012 ErbB signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04668 TNF signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04664 Fc epsilon RI signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04926 Relaxin signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04935 Growth hormone synthesis, secretion and action
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09158 Development and regeneration
   04361 Axon regeneration
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05161 Hepatitis B
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05169 Epstein-Barr virus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05132 Salmonella infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05135 Yersinia infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05418 Fluid shear stress and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE7 family
   K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4

Other DBs

GO:

0004708

Genes

HSA:	6416(MAP2K4)

PTR:	455065(MAP2K4)

PPS:	100991495(MAP2K4)

GGO:	101143954(MAP2K4) 101154090

PON:	100439299(MAP2K4)

PPYG:

129016682(MAP2K4)

NLE:	100587718(MAP2K4)

HMH:	116459332(MAP2K4)

SSYN:

129470325(MAP2K4)

MCC:	718155(MAP2K4)

MCF:	102125035(MAP2K4)

MTHB:

126939572

MNI:	105473552(MAP2K4)

CSAB:

103242403(MAP2K4)

CATY:

105581389(MAP2K4)

PANU:

101015667(MAP2K4)

TGE:	112609481(MAP2K4)

MLEU:

105528792(MAP2K4)

RRO:	104672345(MAP2K4)

RBB:	108517313(MAP2K4)

TFN:	117067678(MAP2K4)

PTEH:

111523480(MAP2K4)

CANG:

105505414(MAP2K4)

CJC:	100386168(MAP2K4)

SBQ:	101037589(MAP2K4)

CIMI:

108306463(MAP2K4)

ANAN:

105717705(MAP2K4) 135272563

CSYR:

103274589(MAP2K4)

MMUR:

105878202(MAP2K4)

LCAT:

123621224(MAP2K4)

ERUF:

138392476(MAP2K4)

PCOQ:

105818077(MAP2K4)

OGA:	100945898(MAP2K4)

MMU:	26398(Map2k4)

MCAL:

110304803(Map2k4)

MPAH:

110331563(Map2k4)

RNO:	287398(Map2k4)

MCOC:

116079018(Map2k4)

ANU:	117710639(Map2k4)

ASYL:

127693731(Map2k4)

MUN:	110552225(Map2k4)

CGE:	100770977(Map2k4)

MAUA:

101823794(Map2k4)

PROB:

127219129(Map2k4)

PLEU:

114693118(Map2k4)

MORG:

121456383(Map2k4)

MFOT:

126513961

AAMP:

119813036(Map2k4)

CNL:	130877305(Map2k4)

NGI:	103752052(Map2k4)

HGL:	101705822(Map2k4)

CPOC:

100733674(Map2k4)

CCAN:

109693003(Map2k4)

DORD:

105983268(Map2k4)

DSP:	122119529(Map2k4)

DMER:

138830556(Map2k4)

PLOP:

125366471(Map2k4)

NCAR:

124980435

MMMA:

107158053(Map2k4)

ITI:	101975990(Map2k4)

OCU:

100344852

OPI:	101517343(MAP2K4)

OCZ:	121170465(MAP2K4)

TUP:	102493856(MAP2K4)

GVR:	103600274(MAP2K4)

CFA:	489508(MAP2K4)

CLUD:

112647348(MAP2K4)

VVP:	112924907(MAP2K4)

VLG:	121499547(MAP2K4)

NPO:	129497178(MAP2K4)

AML:	100475919(MAP2K4)

UMR:	103660510(MAP2K4)

UAH:	113271224(MAP2K4)

UAR:	123792071(MAP2K4)

ELK:

111161210

LLV:

125087109

MPUF:

101692465(MAP2K4)

MNP:	132003163(MAP2K4)

MLK:	131815673(MAP2K4)

NVS:	122906771(MAP2K4)

ORO:	101386473(MAP2K4)

EJU:	114197856(MAP2K4)

ZCA:	113939897(MAP2K4)

MLX:	118000083(MAP2K4)

NSU:	110584510(MAP2K4)

LWW:	102737019(MAP2K4)

FCA:	101086432(MAP2K4)

PYU:	121015745(MAP2K4)

PCOO:

112857039(MAP2K4)

PBG:	122484971(MAP2K4)

PVIV:

125151583(MAP2K4)

LRUF:

124519495

LGF:	123603027(MAP2K4)

AJU:

106986552

PTG:	102966812(MAP2K4)

PPAD:

109246076(MAP2K4)

PUC:

125927589

PLEZ:

122207390(MAP2K4)

HHV:	120231429(MAP2K4)

BTA:	526469(MAP2K4)

BOM:	102287278(MAP2K4)

BIU:	109573969(MAP2K4)

BBUB:

102395178(MAP2K4)

BKE:	129649259(MAP2K4)

BBIS:

104990873(MAP2K4)

CHX:	102175799(MAP2K4)

OAS:	101115045(MAP2K4)

BTAX:

128064467(MAP2K4)

CSUM:

138083165(MAP2K4)

ODA:	120865967(MAP2K4)

CCAD:

122428005 122445001(MAP2K4)

MREE:

136148887(MAP2K4)

OVR:	110146312(MAP2K4)

MBEZ:

129544045(MAP2K4)

SSC:	100520100(MAP2K4)

CFR:	102513578(MAP2K4)

CBAI:

105077599(MAP2K4)

CDK:	105095916(MAP2K4)

VPC:	102541172(MAP2K4)

BACU:

103012105(MAP2K4)

BMUS:

118886388(MAP2K4)

LVE:	103091203(MAP2K4)

OOR:	101270607(MAP2K4)

LALB:

132511165(MAP2K4)

GMF:	115855808(MAP2K4)

DDP:	132414195(MAP2K4)

DLE:	111186018(MAP2K4)

PCAD:

102993818(MAP2K4)

PSIU:

116745732(MAP2K4) 116753033

PPHC:

136138072(MAP2K4)

NASI:

112404578(MAP2K4)

ECB:	100073094(MAP2K4)

EPZ:	103567795(MAP2K4)

EAI:	106845730(MAP2K4)

MYB:	102244251(MAP2K4)

MYD:	102769098(MAP2K4)

MMYO:

118672164(MAP2K4)

MLF:	102438357(MAP2K4)

MDT:	132217995(MAP2K4)

MYUM:

138994872(MAP2K4)

PKL:	118726732(MAP2K4)

EFUS:

103296845(MAP2K4)

MNA:	107544551(MAP2K4)

DRO:	112308830(MAP2K4)

SHON:

118974732(MAP2K4)

AJM:	119057169(MAP2K4) 119061575

PDIC:

114514974(MAP2K4)

PHAS:

123809359(MAP2K4)

MMF:	118633861(MAP2K4)

PPAM:

129068797(MAP2K4)

HAI:	109389137(MAP2K4)

RFQ:	117013460(MAP2K4)

PALE:

102894945(MAP2K4)

PGIG:

120589749(MAP2K4)

PVP:	105291271(MAP2K4)

RAY:	107517401(MAP2K4)

MJV:	108397589(MAP2K4)

TOD:	119232588(MAP2K4)

SARA:

101542924(MAP2K4)

SFUM:

130027171(MAP2K4)

SETR:

126013713(MAP2K4)

LAV:	100655007(MAP2K4)

TMU:

101349700

ETF:	101647011(MAP2K4)

DNM:	101415898(MAP2K4)

MDO:	100019828(MAP2K4)

GAS:	123247702(MAP2K4)

SHR:	100931587(MAP2K4)

AFZ:

127560734

PCW:	110193880(MAP2K4)

TVP:	118847629(MAP2K4) 118848543

PBRV:

138152711(MAP2K4)

MLAO:

141514360(MAP2K4)

OAA:	100091407(MAP2K4)

TACU:

119923470(MAP2K4)

GGA:	417312(MAP2K4)

PCOC:

116235559(MAP2K4)

MGP:	100544828(MAP2K4)

CJO:	107322213(MAP2K4)

TPAI:

128083179(MAP2K4)

LMUT:

125702281(MAP2K4)

NMEL:

110407172(MAP2K4)

APLA:

101805315(MAP2K4)

AACU:

137841883(MAP2K4)

ACYG:

106047193(MAP2K4)

CATA:

118255568(MAP2K4)

AFUL:

116496474(MAP2K4)

TGU:	100219801(MAP2K4)

LSR:	110474922 110477020

SCAN:

103823926(MAP2K4)

PMOA:

120498268(MAP2K4)

OTC:	121348148(MAP2K4)

PRUF:

121352721(MAP2K4)

ATRC:

139602597(MAP2K4)

GFR:	102037348(MAP2K4)

FAB:	101822010(MAP2K4)

OMA:	130260560(MAP2K4)

PHI:	102102585(MAP2K4)

PMAJ:

107212510(MAP2K4)

CCAE:

111937201(MAP2K4)

CCW:	104695676(MAP2K4)

CBRC:

103618010(MAP2K4)

ACOE:

138120024(MAP2K4)

ETL:	114067595(MAP2K4)

ZAB:	102069081(MAP2K4)

ZLE:	135455301(MAP2K4)

ACHL:

103806832

SVG:	106859512(MAP2K4)

MMEA:

130580863(MAP2K4)

HRT:	120761030(MAP2K4)

SATI:

136369358(MAP2K4)

CFAI:

136299131(MAP2K4)

CCIC:

134051938(MAP2K4)

FPG:	101918161(MAP2K4)

FCH:	102047307(MAP2K4)

NNT:	104409457(MAP2K4)

SHAB:

115616509(MAP2K4)

ACUN:

113486906(MAP2K4)

SURA:

141952376(MAP2K4)

TALA:

104367171(MAP2K4)

ACHC:

115341201(MAP2K4)

HALD:

104314879(MAP2K4)

HLE:	104839249(MAP2K4)

AGEN:

126043987

HHAR:

128151528(MAP2K4)

BBUT:

142038904(MAP2K4)

GCL:

127023978

CSTI:

104561710(MAP2K4)

MNB:	103771091(MAP2K4)

DPUB:

104306015(MAP2K4)

PPUS:

135179403(MAP2K4)

AVIT:

104272771(MAP2K4)

BRHI:

104491262(MAP2K4)

EGZ:	104133811(MAP2K4)

NNI:	104014564(MAP2K4)

PCRI:

104025559

PADL:

103925347(MAP2K4)

AFOR:

103899671(MAP2K4)

FGA:	104084021(MAP2K4)

CBOR:

142091037(MAP2K4)

GSTE:

104254634(MAP2K4)

CBOY:

140660367(MAP2K4)

MAME:

142417864(MAP2K4)

CLV:	102085780(MAP2K4)

CNIC:

135995924(MAP2K4)

MUI:

104546836

PGUU:

104465484(MAP2K4)

PLET:

104624711

EHS:

104504434

CMAC:

104478299

CUCA:

104057891(MAP2K4)

BREG:

104638320(MAP2K4)

GAME:

129214515(MAP2K4)

OHA:	104332595(MAP2K4)

CPEA:

104398220(MAP2K4)

CVF:	104294713(MAP2K4)

RTD:	128917754(MAP2K4)

CRID:

134523272(MAP2K4)

LMIC:

141751005(MAP2K4)

NARQ:

141472780(MAP2K4)

AAM:	106496868(MAP2K4)

AROW:

112970862(MAP2K4)

NPD:	112957684(MAP2K4)

TGT:	104569701(MAP2K4)

DNE:	112995561(MAP2K4)

SCAM:

104147585(MAP2K4)

ASN:	102379245(MAP2K4)

AMJ:	102577347(MAP2K4)

CPOO:

109310858(MAP2K4)

GGN:	109286977(MAP2K4)

PSS:	102452927(MAP2K4)

CIZ:	142023447(MAP2K4)

CMY:	102929430(MAP2K4)

CCAY:

125620985(MAP2K4)

LKP:	140897544(MAP2K4)

NDS:	141998937(MAP2K4)

DCC:	119842738(MAP2K4)

CPIC:

101939128(MAP2K4)

TST:	117887611(MAP2K4)

CABI:

116838497(MAP2K4)

MRV:	120383189(MAP2K4)

ACS:	100556629(map2k4)

ASAO:

132768541(MAP2K4)

PVT:	110075065(MAP2K4)

SUND:

121921431(MAP2K4)

PBI:	103061657(MAP2K4)

PMUR:

107282461(MAP2K4)

CTIG:

120298338(MAP2K4)

PGUT:

117660435(MAP2K4)

PCAE:

139312581(MAP2K4)

APRI:

131193212(MAP2K4)

PTEX:

113437210(MAP2K4)

NSS:	113412143(MAP2K4)

VKO:	123035486(MAP2K4)

PMUA:

114590704(MAP2K4)

PRAF:

128407584(MAP2K4)

ZVI:	118079904(MAP2K4)

HCG:	128341738(MAP2K4)

GJA:	107123125(MAP2K4)

STOW:

125428363(MAP2K4)

EMC:	129328213(MAP2K4)

XLA:	399471(map2k4.L) 431908(map2k4.S)

XTR:	100135013(map2k4)

NPR:	108801499(MAP2K4)

RTEM:

120919144(MAP2K4)

PADS:

140325351(MAP2K4)

BBUF:

121004815(MAP2K4)

BGAR:

122924109(MAP2K4)

DTC:	141094032(MAP2K4)

PWL:	138246126(MAP2K4)

MUO:	115473210(MAP2K4)

GSH:	117367978(MAP2K4)

DRE:	403052(map2k4a) 568951(map2k4b)

SRX:	107719678 107750163 107756562

SANH:

107654000(map2k4) 107695698

SGH:	107556463 107570719 107575628 107601595

CCAR:

109060014(map2k4b) 109069591 109113379(map2k4a)

CAUA:

113055203 113067838 113101088 113112012

CGIB:

127953277 127955978 127969396

PTET:

122332668(map2k4b) 122341614(map2k4a)

LROH:

127162692(map2k4a) 127173925(map2k4b)

GRF:	141298116(map2k4b) 141331972(map2k4a)

OMC:	131537043(map2k4a) 131550610(map2k4b)

PPRM:

120464313(map2k4b) 120466649(map2k4a)

RKG:	130096659(map2k4b)

MAMB:

125255358(map2k4b) 125274581(map2k4a)

CIDE:

127508428 127523337

CERY:

137007833(map2k4b) 137017221(map2k4a)

MASI:

127423069 127427504 127449868 127451998

TROS:

130561750 130569375(map2k4b)

TDW:	130426180 130426191 130439253(map2k4b)

MANU:

129420344(map2k4b) 129436724 141351202

PDAB:

135734292 135739419(map2k4b) 135768864

IPU:	108272999(map2k4a) 108274195(map2k4b)

IFU:	128615580 128616832(map2k4b)

PHYP:

113523969 113527144

SMEO:

124382022 124388990(map2k4b)

TFD:	113650543(map2k4a) 113662612(map2k4b)

TVC:	132840121(map2k4b) 132842580(map2k4a)

CGAR:

128515724(map2k4a) 128541222(map2k4b)

NGRA:

132870606(map2k4a) 132898203(map2k4b)

TRN:	134321183(map2k4b) 134334263(map2k4a)

AMEX:

103042940(map2k4b) 103045018(map2k4a)

CMAO:

118805346(map2k4a) 118809534(map2k4b)

EEE:	113570943 113591405

CHAR:

122130773 122130801

SPIL:

134069811(map2k4b) 134076802(map2k4a)

ASAD:

121700432(map2k4b) 121704730(map2k4a)

TRU:	101064151 101078980(map2k4)

TFS:	130515534(map2k4a) 130538645

TNG:	GSTEN00021246G001 GSTEN00021736G001

LCO:	104919484 104933979(map2k4)

NCC:	104946717(map2k4) 104947390

TBEN:

117483619(map2k4b) 117492529

CGOB:

115012187(map2k4) 115024389

PGEO:

117450749 117468287(map2k4b)

GACU:

117536890(map2k4a) 117552371(map2k4b)

EMAC:

134871296 134878056(map2k4a)

ELY:	117247486(map2k4b) 117268464(map2k4a)

EFO:	125878978(map2k4a) 125880365(map2k4b)

PLEP:

121956465 121958469(map2k4b)

SLUC:

116063959(map2k4a) 116067529(map2k4b)

ECRA:

117936603(map2k4b) 117958775(map2k4a)

ESP:	116671100 116703458(map2k4) 116705506

PFLV:

114547952 114569479

GAT:	120827864(map2k4a)

PPUG:

119220593(map2k4a)

AFB:	129093324(map2k4b) 129098482(map2k4a)

CLUM:

117735077(map2k4a) 117749226

PSWI:

130188386(map2k4a) 130203213(map2k4b)

CANA:

137787128 137789375

CVE:	137884023(map2k4a)

MSAM:

119894592 119915646(map2k4b)

SCHU:

122867152(map2k4b) 122868882

CUD:	121528561(map2k4b)

SPUL:

138593655(map2k4b) 138604037

LMIX:

132955001(map2k4b) 132995395

HTC:	141784784(map2k4b) 141809507(map2k4a)

ALAT:

119009363(map2k4b) 119014352(map2k4a)

ASTR:

137588207(map2k4b) 137609460(map2k4a)

MZE:	101478377 101483027

ONL:	100707267(map2k4) 100711257

OAU:	116314247(map2k4a) 116330889(map2k4b)

OLA:	101161098 101174917(map2k4)

OML:	112146279(map2k4a) 112153869(map2k4b)

CSAI:

133418956(map2k4b) 133421893(map2k4a)

XMA:	102225231 102232155(map2k4)

XCO:	114151734 114159409(map2k4)

XHE:	116726663 116734852(map2k4)

PRET:

103469437 103481917(map2k4)

PFOR:

103144535(map2k4)

PLAI:

106964023 106964991

PMEI:

106924851 106927114

GAF:	122822534(map2k4a) 122823156(map2k4b)

PPRL:

129373893 129377465(map2k4b)

CVG:	107091771(map2k4) 107096251

CTUL:

119781970 119796035(map2k4b)

GMU:	124862979 124864757 124875573(map2k4b)

NFU:	107397308(map2k4) 107397353

KMR:	108235888(map2k4b) 108243254(map2k4a)

ALIM:

106531926 106535063

NWH:	119421294(map2k4a) 119423773(map2k4b)

AOCE:

111572496(map2k4b) 111574864(map2k4a)

EJA:	138202318(map2k4b) 138207939(map2k4a)

BFRE:

138626847(map2k4b) 138631262(map2k4a)

MCEP:

124997914(map2k4a) 125022013(map2k4b)

CSEM:

103382416(map2k4) 103392559

POV:	109626687 109633989

SSEN:

122760968(map2k4b) 122785812

SSOE:

131448457(map2k4b) 131475012

HHIP:

117752531(map2k4b) 117766200(map2k4a)

HSP:	118101068(map2k4b) 118123140(map2k4a)

PPLT:

128426514(map2k4b) 128458809(map2k4a)

SMAU:

118286964(map2k4b) 118289134(map2k4a)

LCF:	108873371(map2k4a) 108890897(map2k4b)

SDU:	111217504 111219937

SLAL:

111655523 111667084

XGL:	120786834(map2k4a) 120793976(map2k4b)

HCQ:	109512602 109527782

SSCV:

125983614(map2k4a) 125991606(map2k4b)

SBIA:

133495548(map2k4b) 133514309(map2k4a)

PEE:	133414890 133417708(map2k4b)

PTAO:

133465762(map2k4a) 133468876(map2k4b)

BPEC:

110154054 110157369

ENY:	140358036(map2k4a)

MALB:

109962855 109966673

BSPL:

114845946(map2k4b) 114860625(map2k4a)

SJO:	128378694(map2k4a) 128381649(map2k4b)

SSCO:

133999563(map2k4a) 134003247(map2k4b)

TTY:	137168535 137172396(map2k4b)

GMH:	115530492 115530956

SASA:

100196891(map2k4) 106578855 106589490 106601504

STRU:

115156176 115171440 115201273 115202704

OTW:	112223363 112233675(map2k4b) 112234111 112258936

OMY:	110486602 110491308 110498889(map2k4b) 110538572

OGO:	123999347 124015041 124040120(map2k4b) 124048091

ONE:	115106306 115110714 115110735 115144141

OKI:	109865234 109870111 109879644(map2k4) 109898690

OKE:	118357393(map2k4b) 118365629 118368781 118384713

OMM:	135505216 135523750(map2k4b) 135554391 135555381

OCLA:

139364965 139367911 139376661 139421449

SALP:

111968240 111981594 111981595 112070936

SNH:	120029571(map2k4b) 120034212 120039974 120046086

SFON:

129815794 129825104 129829023(map2k4b) 129833488

CCLU:

121547425(map2k4b) 121556829 121560426 121582237

ELS:	105022938 105023011

OEP:	134031911(map2k4b) 134040210(map2k4a)

SFM:	108940146 114909201

PKI:	111855939 111856922

AANG:

118216885

CCOG:

133114435

LOC:	102683325(map2k4)

PSPA:

121295451 121296282

ARUT:

117423548 117424541

PSEX:

120517075

LCM:	102352547(MAP2K4)

CMK:	103175698(map2k4b)

CPLA:

122562031(map2k4a)

CPUN:

140463869(map2k4a)

HOC:	132827663(map2k4a)

SCAU:

119953669(map2k4a)

LERI:

129708125

HAKA:

140714563(map2k4a)

PMRN:

116946147(MAP2K4)

LRJ:	133353425(MAP2K4)

BFO:

118429574

BBEL:

109483437

CIN:	778672(mapkk4)

SCLV:

120339179

CLEP:

143459931

SPU:	115923567 589763

LPIC:

LVG:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG9738(Mkk4)

DER:

6552519

DSE:

6607241

DSI:	Dsimw501_GD20857(Dsim_GD20857)

DYA:	Dyak_GE24839

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10233

DAZ:

108621241

DNV:

108659014

DHE:

111604816

DVI:	6633159(Mkk4)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135949136(Mkk4)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ010611

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:	105671428(Mkk4)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138138789(Mkk4)

ESIM:

136415019

EFOR:

136339904

SOY:

115881802

RFG:	143189602(Mkk4)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200381

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137931973(Mkk4)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111046120 111059325 120348883 120352873

LDA:

142329829

HVI:

124353978

MQU:

129001114

PHU:	Phum_PHUM196800

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138706102(Mkk4)

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_322328

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123745546(Mkk4)

CQD:	128697563(Mkk4)

PTRU:

123513830

ESN:

126985135

MNZ:

135212462

MRJ:	136832697(Mkk4)

PORN:

139767388(Mkk4)

HAZT:

OOT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

DALB:

RSAN:

RMP:

OTI:

VDE:

VJA:

GOE:	100897603 108864322

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F42G10.2(mkk-4) CELE_VZC374L.1(sek-6) CELE_ZC449.3(sek-3)

CBR:	CBG_01940(Cbr-mkk-4) CBG_14588

CRQ:	GCK72_023507 GCK72_024350

NAI:	NECAME_08069

BMY:	BM_BM4039(Bm4039) BM_BM9351(Bma-sek-3)

LOA:	LOAG_04773 LOAG_11954

TSP:

Tsp_00085

HRO:	HELRODRAFT_101835 HELRODRAFT_66729

LGI:	LOTGIDRAFT_177777

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:	121379945 121392340 121392341

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115209743 115211857

LJP:

135462122

LAK:	106161192 106172350

SMM:	Smp_086690

SHX:	MS3_00008971(MAP2K6_5)

OVI:	T265_15010

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_21381

AQU:	100638378 100639945

MBR:	MONBRDRAFT_29871

» show all

Reference

PMID:7716521

Authors

Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M

Title

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.

Journal

Science 268:286-90 (1995)
DOI:10.1126/science.7716521

Sequence

[hsa:6416]

LinkDB

ORTHOLOGY: K04433

Entry

K04433                      KO

Symbol

MAP2K6, MKK6

Name

mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]

Pathway

map04010

MAPK signaling pathway

map04015

Rap1 signaling pathway

map04212

Longevity regulating pathway - worm

map04218

Cellular senescence

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04668

TNF signaling pathway

map04750

Inflammatory mediator regulation of TRP channels

map04912

GnRH signaling pathway

map04935

Growth hormone synthesis, secretion and action

map04936

Alcoholic liver disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05132

Salmonella infection

map05135

Yersinia infection

map05145

Toxoplasmosis

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04015 Rap1 signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04668 TNF signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04664 Fc epsilon RI signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04935 Growth hormone synthesis, secretion and action
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09149 Aging
   04212 Longevity regulating pathway - worm
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05161 Hepatitis B
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05163 Human cytomegalovirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05169 Epstein-Barr virus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05135 Yersinia infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05022 Pathways of neurodegeneration - multiple diseases
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05418 Fluid shear stress and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE7 family
   K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6

Other DBs

GO:

0004708

Genes

HSA:	5608(MAP2K6)

PTR:	468310(MAP2K6)

PPS:	100972424(MAP2K6)

GGO:	101142374(MAP2K6)

PON:	100448382(MAP2K6)

PPYG:

129016958(MAP2K6)

NLE:	100591256(MAP2K6)

HMH:	116483711(MAP2K6)

SSYN:

129461683(MAP2K6)

MCC:	693914(MAP2K6)

MCF:	101925060(MAP2K6)

MTHB:

126939854

MNI:	105469063(MAP2K6)

CSAB:

103243132(MAP2K6)

CATY:

105577799(MAP2K6)

PANU:

101001515(MAP2K6)

TGE:	112609390(MAP2K6)

MLEU:

105544191(MAP2K6)

RRO:	104654038(MAP2K6)

RBB:	108523215(MAP2K6)

TFN:	117066601(MAP2K6)

PTEH:

111542478(MAP2K6)

CANG:

105505905(MAP2K6)

CJC:	100397389(MAP2K6)

SBQ:	101030219(MAP2K6)

CIMI:

108281677(MAP2K6)

ANAN:

105718182(MAP2K6)

CSYR:

103254297

MMUR:

105861678(MAP2K6)

LCAT:

123650624(MAP2K6)

ERUF:

138392214(MAP2K6)

PCOQ:

105824710(MAP2K6)

OGA:	100962457(MAP2K6)

MMU:	26399(Map2k6)

MCAL:

110304684(Map2k6)

MPAH:

110331335(Map2k6)

RNO:	114495(Map2k6)

MCOC:

116079135(Map2k6)

ANU:	117710811(Map2k6)

ASYL:

127694765(Map2k6)

MUN:	110563015(Map2k6)

CGE:

100771767

MAUA:

101833237(Map2k6)

PROB:

127218712(Map2k6)

PLEU:

114690458(Map2k6)

PMAV:

102908917(Map2k6)

MORG:

121436314(Map2k6)

MFOT:

126500469

AAMP:

119812035(Map2k6)

CNL:	130877181(Map2k6)

NGI:	103742218(Map2k6)

HGL:	101703028(Map2k6)

CPOC:

100731419(Map2k6)

CCAN:

109698990(Map2k6)

DORD:

106002705(Map2k6)

DSP:	122128383(Map2k6)

DMER:

138807415(Map2k6)

PLOP:

125365364(Map2k6)

NCAR:

124981341

MMMA:

107157181(Map2k6)

OCU:

100355230

OPI:	101519949(MAP2K6)

OCZ:	121162521(MAP2K6)

TUP:	102482054(MAP2K6)

GVR:	103583282(MAP2K6)

CFA:	480454(MAP2K6)

CLUD:

112652877(MAP2K6)

VVP:	112920749(MAP2K6)

VLG:	121473314(MAP2K6)

NPO:	129508745(MAP2K6)

AML:	100469111(MAP2K6)

UMR:	103665687(MAP2K6)

UAH:	113265227(MAP2K6)

UAR:	123803240(MAP2K6)

ELK:

111158041

LLV:

125087142

MPUF:

101670597(MAP2K6)

MNP:	132004478(MAP2K6)

MLK:	131816040(MAP2K6)

NVS:	122906041(MAP2K6)

ORO:	101382167(MAP2K6)

EJU:	114216197(MAP2K6)

ZCA:	113908216(MAP2K6)

MLX:	118024329(MAP2K6)

NSU:	110570428(MAP2K6)

LWW:	102743800(MAP2K6)

FCA:	101089813(MAP2K6)

PYU:	121015350(MAP2K6)

PCOO:

112864599(MAP2K6)

PBG:	122485830(MAP2K6)

PVIV:

125151813(MAP2K6)

LRUF:

124513476

LGF:	123603984(MAP2K6)

AJU:

106988444

PTG:	102966485(MAP2K6)

PPAD:

109277026(MAP2K6)

PUC:

125926707

PLEZ:

122206178(MAP2K6)

HHV:	120230246(MAP2K6)

BTA:	286883(MAP2K6)

BOM:	102272962(MAP2K6)

BIU:	109573853(MAP2K6)

BBUB:

102403288(MAP2K6)

BKE:	129648559(MAP2K6)

BBIS:

105000295(MAP2K6)

CHX:	102169516(MAP2K6)

OAS:	101115047(MAP2K6)

BTAX:

128065178(MAP2K6)

CSUM:

138083118(MAP2K6)

ODA:	120866612(MAP2K6)

CCAD:

122429019(MAP2K6)

MREE:

136150052(MAP2K6)

OVR:	110145173(MAP2K6)

MBEZ:

129544772(MAP2K6)

SSC:	100625946(MAP2K6)

CFR:	102519784(MAP2K6)

CBAI:

105063918(MAP2K6)

CDK:	105085694(MAP2K6)

VPC:	102545165(MAP2K6)

BACU:

103012537(MAP2K6)

BMUS:

118886696(MAP2K6)

LVE:

103081641

OOR:	101280413(MAP2K6)

LALB:

132511381(MAP2K6)

GMF:	115842766(MAP2K6)

DDP:	132414985(MAP2K6)

DLE:	111182897(MAP2K6)

PCAD:

102982175(MAP2K6)

PSIU:

116746300(MAP2K6)

PPHC:

136138033(MAP2K6)

NASI:

112410464(MAP2K6)

ECB:	100053056(MAP2K6)

EPZ:	103564566(MAP2K6)

EAI:	106830236(MAP2K6)

MYB:	102246913(MAP2K6)

MYD:	102759247(MAP2K6)

MMYO:

118672023(MAP2K6)

MLF:	102426303(MAP2K6)

MDT:	132219031(MAP2K6)

MYUM:

138993766(MAP2K6)

PKL:	118702109(MAP2K6)

EFUS:

103299424(MAP2K6)

MNA:	107528394(MAP2K6)

DRO:	112316519(MAP2K6)

SHON:

119003578(MAP2K6)

AJM:	119036284(MAP2K6)

PDIC:

114503069(MAP2K6)

PHAS:

123817154(MAP2K6)

MMF:	118634140(MAP2K6)

PPAM:

129070245(MAP2K6)

HAI:	109371344(MAP2K6)

RFQ:	117013904(MAP2K6)

PALE:

102888822(MAP2K6)

PGIG:

120600014(MAP2K6)

PVP:	105298936(MAP2K6)

RAY:	107510279(MAP2K6)

MJV:	108405137(MAP2K6)

TOD:	119231622(MAP2K6)

SARA:

101542881(MAP2K6)

SFUM:

130035909(MAP2K6)

SETR:

126008206(MAP2K6)

LAV:	100662511(MAP2K6)

TMU:

101344286

ETF:	101643832(MAP2K6)

DNM:	101431376(MAP2K6)

MDO:	100029049(MAP2K6)

GAS:	123246222(MAP2K6)

AFZ:

127560548

PCW:	110219359(MAP2K6)

TVP:	118847672(MAP2K6)

PBRV:

138152587(MAP2K6)

MLAO:

141514157(MAP2K6)

OAA:	100078394(MAP2K6)

TACU:

119937668(MAP2K6)

GGA:	417445(MAP2K6)

PCOC:

116232481(MAP2K6)

MGP:	100545287(MAP2K6)

CJO:	107322198(MAP2K6)

TPAI:

128083050(MAP2K6)

LMUT:

125702133(MAP2K6)

NMEL:

110407251(MAP2K6)

APLA:

119713161(MAP2K6)

AACU:

137841629(MAP2K6)

ACYG:

106034753(MAP2K6)

CATA:

118253982(MAP2K6)

AFUL:

116496466(MAP2K6)

TGU:	100226231(MAP2K6)

LSR:	110473926(MAP2K6)

SCAN:

103819965(MAP2K6)

PMOA:

120505376(MAP2K6)

OTC:	121338227(MAP2K6)

PRUF:

121363365(MAP2K6)

ATRC:

139602032(MAP2K6)

GFR:	102039445(MAP2K6)

FAB:	101819388(MAP2K6)

OMA:	130260495(MAP2K6)

PHI:	102105268(MAP2K6)

PMAJ:

107212284(MAP2K6)

CCAE:

111937452(MAP2K6)

CCW:	104696025(MAP2K6)

CBRC:

103613897(MAP2K6)

ACOE:

138120325(MAP2K6)

ETL:	114060693(MAP2K6)

ZAB:	102067681(MAP2K6)

ZLE:	135455480(MAP2K6)

ACHL:

103799486

SVG:	106856971(MAP2K6)

MMEA:

130584174(MAP2K6)

HRT:	120761127(MAP2K6)

SATI:

136369469(MAP2K6)

CFAI:

136299346(MAP2K6)

CCIC:

134052000(MAP2K6)

FPG:	101913671(MAP2K6)

FCH:	102053088(MAP2K6)

CCRI:

104169320

NNT:	104405440(MAP2K6)

SHAB:

115616735(MAP2K6)

ACUN:

113486793(MAP2K6)

SURA:

141951991(MAP2K6)

TALA:

104367888(MAP2K6)

ACHC:

115341693(MAP2K6)

HALD:

104324566

HLE:	104838787(MAP2K6)

AGEN:

126044026

HHAR:

128150986(MAP2K6)

BBUT:

142038652(MAP2K6)

GCL:

127023976

CSTI:

104561297(MAP2K6)

LDI:	104346570(MAP2K6)

MNB:

103774940

DPUB:

104297856(MAP2K6)

PPUS:

135179688(MAP2K6)

AVIT:

104279348(MAP2K6)

BRHI:

104499360(MAP2K6)

EGZ:	104132828(MAP2K6)

NNI:	104014353(MAP2K6)

PCRI:

104033039

PCAO:

104046303

PADL:

103916640(MAP2K6)

AFOR:

103902435(MAP2K6)

FGA:	104078859(MAP2K6)

CBOR:

142090908(MAP2K6)

GSTE:

104261135(MAP2K6)

CBOY:

140660325(MAP2K6)

MAME:

142417674(MAP2K6)

CLV:	102086996(MAP2K6)

CNIC:

135996024(MAP2K6)

MUI:	104537914(MAP2K6)

PGUU:

104464818

PLET:

104623176

EHS:

104510601

CMAC:

104476633(MAP2K6)

CUCA:

104056925(MAP2K6)

TEO:	104383544(MAP2K6)

BREG:

104640593(MAP2K6)

GAME:

129214693(MAP2K6)

OHA:	104335932(MAP2K6)

ACAR:

104532186

CPEA:

104393228(MAP2K6)

CVF:	104295089(MAP2K6)

RTD:	128917839(MAP2K6)

CRID:

134523240(MAP2K6)

LMIC:

141751314(MAP2K6)

NARQ:

141472755(MAP2K6)

AAM:	106490233(MAP2K6)

AROW:

112966967(MAP2K6)

NPD:	112953655(MAP2K6)

TGT:	104564900(MAP2K6)

DNE:	112982537(MAP2K6)

SCAM:

104146835(MAP2K6)

ASN:	102373782(MAP2K6)

AMJ:	106736984(MAP2K6)

CPOO:

109314938(MAP2K6)

GGN:	109296704(MAP2K6)

PSS:	102461243(MAP2K6)

CIZ:	142023426(MAP2K6)

CMY:	102942953(MAP2K6)

CCAY:

125621197(MAP2K6)

LKP:	140898194(MAP2K6)

NDS:	141998166(MAP2K6)

DCC:	119842822(MAP2K6)

CPIC:

101935028(MAP2K6)

TST:	117887377(MAP2K6)

CABI:

116834835(MAP2K6)

MRV:	120383171(MAP2K6)

ACS:	100567963(map2k6)

ASAO:

132768395(MAP2K6)

PVT:	110077815(MAP2K6)

SUND:

121921526(MAP2K6)

PBI:

103058491

PMUR:

107282569(MAP2K6)

CTIG:

120299971(MAP2K6)

TSR:

106543486

PGUT:

117662946(MAP2K6)

PCAE:

139312701(MAP2K6)

APRI:

131193154(MAP2K6)

PTEX:

113436987(MAP2K6)

NSS:	113417417(MAP2K6)

VKO:	123020202 123030154

PMUA:

114588447(MAP2K6)

PRAF:

128407266(MAP2K6)

ZVI:	118079658(MAP2K6)

HCG:	128345438(MAP2K6)

GJA:	107122462(MAP2K6)

STOW:

125428190(MAP2K6)

EMC:	129328147(MAP2K6)

XLA:	379638(map2k6.L) 399150(map2k3)

XTR:	448132(map2k6)

RTEM:

120919063(MAP2K6)

ACAT:

141113669(MAP2K6)

PADS:

140325554(MAP2K6)

BBUF:

121004730(MAP2K6)

BGAR:

122940256(MAP2K6)

DTC:	141072805(MAP2K6)

PWL:	138245860(MAP2K6)

MUO:	115472304(MAP2K6)

GSH:	117367392(MAP2K6)

DRE:	65239(map2k6)

SRX:	107753245 107755396

SANH:

107684112

SGH:	107561815 107597823

CCAR:

109046639(map2k6) 109103603

CAUA:

113055995 113075496 113111626 113111658

CGIB:

127969198

PTET:

122355522(map2k6)

LROH:

127174013(map2k6)

GRF:	141297353(map2k6)

OMC:	131551136(map2k6)

PPRM:

120474717(map2k6)

RKG:	130080158(map2k6)

MAMB:

125255310(map2k6)

CIDE:

127524204

CERY:

137007492(map2k6)

MASI:

127423123 127426946

TROS:

130569286(map2k6)

TDW:	130438964(map2k6)

MANU:

129420284(map2k6)

PDAB:

135744650(map2k6)

IPU:	108274084(map2k6)

IFU:	128616705(map2k6)

PHYP:

113527237

SMEO:

124388598(map2k6)

TFD:	113651614(map2k6)

TVC:	132862615(map2k6)

CGAR:

128540965(map2k6)

NGRA:

132898602(map2k6)

TRN:	134321172(map2k6)

AMEX:

111191499(map2k6)

CMAO:

118809070(map2k6)

EEE:

113585643

CHAR:

105893604(map2k6) 105894965

SPIL:

134069816(map2k6) 134076749

ASAD:

121699706(map2k6) 121705384

TRU:	101064673 101073869

TFS:	130515448 130523603(map2k6)

TNG:	GSTEN00018597G001

LCO:	104925053 104928151

NCC:	104944235(map2k6) 104948325

TBEN:

117473856(map2k6) 117492626

CGOB:

115012637 115024590

PGEO:

117451034 117464865(map2k6)

GACU:

117548594 117553527(map2k6)

EMAC:

134871028(map2k6) 134878240

ELY:	117247143(map2k6) 117268766

EFO:	125879506 125880680(map2k6)

PLEP:

121957025 121958775(map2k6)

SLUC:

116059565 116061169(map2k6)

ECRA:

117936952(map2k6) 117958358

ESP:	116671244 116702724

PFLV:

114548455 114569386

GAT:	120819366(map2k6) 120828362

PPUG:

119213268(map2k6) 119220864

AFB:	129091200(map2k6) 129097967

CLUM:

117735377 117748744(map2k6)

PSWI:

130188772 130203445

CANA:

137786866 137801880(map2k6)

CVE:	137878311(map2k6)

MSAM:

119890456 119915650(map2k6)

SCHU:

122867604(map2k6) 122868911

CUD:	121503317 121528906(map2k6)

SPUL:

138593211(map2k6) 138602652

LMIX:

132955159(map2k6) 132995349

HTC:	141784979(map2k6) 141809870

ALAT:

119010027(map2k6) 119014532

ASTR:

137588098(map2k6) 137609550

MZE:	101473145 101479195

ONL:	100697168 100697345

OAU:	116325201 116328614(map2k6)

OLA:	101163933 101170843

OML:	112146636 112154201(map2k6)

CSAI:

133418847 133421715

XMA:	102219049 102221885

XCO:	114152162 114160221

XHE:	116727357 116735977

PRET:

103468828 103481589

PFOR:

103140939 103150707 103150725

PLAI:

106949098 106951757

PMEI:

106920063 106922419 106931279

GAF:	122821663 122823765(map2k6)

PPRL:

129363777 129368241(map2k6)

CVG:	107083188 107090247

CTUL:

119775958(map2k6) 119778260

GMU:	124862863 124864761 124875121(map2k6)

NFU:	107378273 107387425

KMR:	108241241 108245617

ALIM:

106528548 106529047

NWH:	119421012 119424210(map2k6)

AOCE:

111564651 111585477(map2k6)

EJA:	138197955 138204622(map2k6)

BFRE:

138623388 138635726(map2k6)

MCEP:

124998191 125022674(map2k6)

CSEM:

103382222 103392800

POV:	109634317 109647356

SSEN:

122759414(map2k6) 122765439 122784954

SSOE:

131448489(map2k6) 131475971

HHIP:

117752994(map2k6) 117766311

HSP:	118100279(map2k6) 118123527

PPLT:

128426937(map2k6) 128459295

SMAU:

118287208(map2k6) 118288528

LCF:	108876848(map2k6) 108902699

SDU:	111219741 111227238

SLAL:

111657787 111664323

XGL:	120794111(map2k6) 120805077

HCQ:	109518564 109532551

SSCV:

125983484(map2k6)

SBIA:

133514631(map2k6)

PEE:	133414425(map2k6)

PTAO:

133465694 133468948(map2k6)

BPEC:

110166072 110166701

ENY:	140358426(map2k6) 140379563

MALB:

109962725 109972262

BSPL:

114846339(map2k6) 114860381

SJO:	128378855 128381286(map2k6)

SSCO:

133999490 134003318(map2k6)

TTY:	137171508(map2k6) 137201266

GMH:	115531188 115556713

SASA:

100136944(mkk6a) 100192337(mkk6b) 100192338(mkk6c) 106601934 106606355 106606359

STRU:

115153520 115171844 115201695 115207531

OTW:	112224035 112257868(map2k6) 121843802

OMY:	110487439 110499544 110502795(map2k6) 110518132

OGO:	124020632 124025444 124025716 124026110 124038478 124040414(map2k6)

ONE:	115112972 115118936

OKI:	109870395 109876913 109899929

OKE:	118375502 118397477

OMM:	135512066 135523393 135537073 135537085

OCLA:

139376974 139381080 139394644 139401957

SALP:

111968176 111978520 112077035

SNH:	120029867 120043801 120045697(map2k6)

SFON:

129828624 129834005 129834024 129861039

CCLU:

121547737 121551598 121575920 123482637 123483342

ELS:	105027407 105031287

OEP:	134009526(map2k6)

SFM:	108922496 108924851(map2k6)

PKI:	111848425(map2k6) 111859759

AANG:

118217112(map2k6)

AROT:

135243376(map2k6)

CCOG:

133114560(map2k6)

LOC:	102692628(map2k6)

PSPA:

121295305 121296108

ARUT:

117422947 117424624

LCM:	102362389(MAP2K6)

CMK:

RTP:

CPLA:

CPUN:

HOC:	132827776(map2k6)

SCAU:

119953297(map2k6)

STOZ:

140395596(map2k6)

LERI:

129708248

HAKA:

140714725

PMRN:

116951466 116954104

LRJ:	133340621 133347708

BFO:

118428978

BBEL:

109485302

CIN:	778902(mapkk3/6)

CLEP:

SPU:

LPIC:

LVG:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

PPOI:

DSV:

RSAN:

RMP:

VDE:

TUT:

LPOL:

PMEO:

CEL:	CELE_R03G5.2(sek-1)

CBR:	CBG_16802(Cbr-sek-1)

CRQ:	GCK72_024854

NAI:	NECAME_00159

LOA:	LOAG_02233

HRO:	HELRODRAFT_74733

GAE:

121378396

HRJ:	124284413 124292347

CRG:

CANU:

MYI:

PMAX:

YBA:

MCAF:

MMER:

RPHI:

SMM:	Smp_073510

SHX:	MS3_00003218(MAP2K6_3)

LLON:

135487318

NVE:	5499944 5509635

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

XEN:

HMG:

HSY:

RES:

AQU:

Reference

PMID:8622669

Authors

Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ

Title

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

Journal

Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247

Sequence

[hsa:5608]

LinkDB

DBGET integrated database retrieval system