| | ORTHOLOGY: K04694 | |
Entry |
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Symbol |
SOCS1, JAB
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Name |
suppressor of cytokine signaling 1
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Pathway |
map04935 | Growth hormone synthesis, secretion and action |
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Disease |
H02561 | Familial autoinflammatory syndrome with or without immunodeficiency |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
04917 Prolactin signaling pathway
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
04935 Growth hormone synthesis, secretion and action
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
09158 Development and regeneration
04380 Osteoclast differentiation
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
09174 Infectious disease: parasitic
05145 Toxoplasmosis
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
Multi subunit Ring-finger type E3
Cul5 complex
Target recognizing subunit
K04694 SOCS1, JAB; suppressor of cytokine signaling 1
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Genes |
» show all
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Reference |
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Authors |
Ohya Ki, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H |
Title |
SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. |
Journal |
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Sequence |
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Reference |
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Authors |
Rui L, Yuan M, Frantz D, Shoelson S, White MF. |
Title |
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. |
Journal |
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Sequence |
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Reference |
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Authors |
Kamizono S, Hanada T, Yasukawa H, Minoguchi S, Kato R, Minoguchi M, Hattori K, Hatakeyama S, Yada M, Morita S, Kitamura T, Kato H, Nakayama Ki, Yoshimura A |
Title |
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. |
Journal |
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Sequence |
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LinkDB |
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