KEGG ORTHOLOGY: K04730

ORTHOLOGY: K04730

Entry

K04730                      KO

Symbol

IRAK1

Name

interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]

Pathway

map04010

MAPK signaling pathway

map04064

NF-kappa B signaling pathway

map04620

Toll-like receptor signaling pathway

map04624

Toll and Imd signaling pathway

map04722

Neurotrophin signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05132

Salmonella infection

map05133

Pertussis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05145

Toxoplasmosis

map05152

Tuberculosis

map05161

Hepatitis B

map05162

Measles

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   04064 NF-kappa B signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   04624 Toll and Imd signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05161 Hepatitis B
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05171 Coronavirus disease - COVID-19
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05162 Measles
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05168 Herpes simplex virus 1 infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05169 Epstein-Barr virus infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05132 Salmonella infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05135 Yersinia infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05133 Pertussis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05152 Tuberculosis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05140 Leishmaniasis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05142 Chagas disease
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04730  IRAK1; interleukin-1 receptor-associated kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  IRAK family
   K04730  IRAK1; interleukin-1 receptor-associated kinase 1

Genes

HSA:	3654(IRAK1)

PTR:	465935(IRAK1)

PPS:	100981891(IRAK1)

GGO:	101140803(IRAK1)

PON:	100437883(IRAK1)

PPYG:

129023968(IRAK1)

NLE:	100588136(IRAK1)

HMH:	116812171(IRAK1)

SSYN:

129475749(IRAK1)

MCC:	699919(IRAK1)

MCF:	102134829(IRAK1)

MTHB:

126945458

MNI:	105467308(IRAK1)

CSAB:

103232815(IRAK1)

CATY:

105598716(IRAK1)

PANU:

101018336(IRAK1)

TGE:	112615074(IRAK1)

MLEU:

105555370(IRAK1)

RRO:	104662981(IRAK1)

RBB:	108535063(IRAK1)

TFN:	117063914(IRAK1)

PTEH:

111531307(IRAK1)

CANG:

105521650(IRAK1)

CJC:	100414273(IRAK1)

SBQ:	101052342(IRAK1)

CIMI:

108294753(IRAK1)

ANAN:

105707114(IRAK1)

CSYR:

103274081(IRAK1)

MMUR:

105867330(IRAK1)

LCAT:

123628474(IRAK1)

ERUF:

138377827(IRAK1)

PCOQ:

105824543(IRAK1)

OGA:	100951843(IRAK1)

MMU:	16179(Irak1)

MCAL:

110286819(Irak1)

MPAH:

110313647(Irak1)

RNO:	363520(Irak1)

MCOC:

116086115(Irak1)

ANU:	117694459(Irak1)

ASYL:

127674889(Irak1) 127692783

MUN:	110566945(Irak1)

CGE:	100773909(Irak1)

MAUA:

101830300(Irak1)

PROB:

127217354(Irak1)

PLEU:

114706205(Irak1)

PMAV:

102925638(Irak1)

MORG:

121437200 121440306

MFOT:

126490221

AAMP:

119805097(Irak1)

CNL:	130867725(Irak1)

NGI:	103731212(Irak1)

HGL:	101699021(Irak1)

CPOC:

100735146(Irak1)

CCAN:

109690874(Irak1)

DORD:

106000170(Irak1)

DSP:	122097062(Irak1)

DMER:

138839972(Irak1)

PLOP:

125343817(Irak1)

NCAR:

124972468

MMMA:

107160297(Irak1)

ITI:	101972544(Irak1)

OCU:

100354743

OPI:	101523491(IRAK1)

OCZ:	121152508(IRAK1)

TUP:	102473549(IRAK1)

GVR:	103595100(IRAK1)

CFA:	492247(IRAK1)

CLUD:

112668372(IRAK1)

VVP:	112911496(IRAK1)

VLG:	121483388(IRAK1)

NPO:	129518585(IRAK1)

AML:	100484977(IRAK1)

UMR:	103679690(IRAK1)

ELK:

111139109

LLV:

125091300

MPUF:

101673776(IRAK1)

MNP:	132007541(IRAK1)

MLK:	131820794(IRAK1)

NVS:	122896442(IRAK1)

ORO:	101382179(IRAK1)

EJU:	114201598(IRAK1)

ZCA:	113931272(IRAK1)

MLX:	118014698(IRAK1)

MANO:

123850881(IRAK1)

NSU:	110574588(IRAK1)

LWW:

102726302

FCA:	101090500(IRAK1)

PYU:	121025099(IRAK1)

PCOO:

112870846(IRAK1)

PBG:	122477987(IRAK1)

PVIV:

125159423(IRAK1)

LRUF:

124525860

LGF:	123595024(IRAK1)

AJU:

113597389

PPAD:

109259848(IRAK1)

PUC:

125932080

HHV:	120221716(IRAK1)

CCRU:

144236008(IRAK1)

BTA:	533953(IRAK1)

BOM:	102277837(IRAK1)

BIU:	109555285(IRAK1)

BJV:	133242808(IRAK1)

BBUB:

102396505(IRAK1)

BKE:	129639749(IRAK1)

BBIS:

104991529

CHX:	102177432(IRAK1)

OAS:	101121405(IRAK1)

OCAN:

138931111(IRAK1)

BTAX:

128069805(IRAK1)

CSUM:

138070875(IRAK1)

ODA:	120881806(IRAK1)

CCAD:

122434303(IRAK1)

MREE:

136153383(IRAK1)

OVR:	110136267(IRAK1)

MBEZ:

129564634(IRAK1)

SSC:	396606(IRAK1)

CFR:	102523767(IRAK1)

CBAI:

105076069(IRAK1)

CDK:	105098727(IRAK1)

VPC:	102529835(IRAK1)

BACU:

102998365(IRAK1)

BMUS:

118888703(IRAK1)

LVE:	103074326(IRAK1)

OOR:	101280639(IRAK1)

LALB:

132512935(IRAK1)

GMF:	115849301(IRAK1)

DLE:	111170605(IRAK1)

PCAD:

112062410(IRAK1)

PSIU:

116747835(IRAK1)

PPHC:

136142419(IRAK1)

NASI:

112406760(IRAK1)

ECB:	100059262(IRAK1)

EPZ:	103545279(IRAK1)

EAI:	106825607(IRAK1)

MYB:	102245410(IRAK1)

MYD:	102765985(IRAK1)

MMYO:

118654047(IRAK1)

MLF:	102418742(IRAK1)

MDT:	132224970(IRAK1)

MYUM:

138994550(IRAK1)

PKL:	118706455(IRAK1)

EFUS:

103302249(IRAK1)

MNA:	107538794(IRAK1)

DRO:	112296346(IRAK1)

SHON:

118994306(IRAK1)

AJM:	119053563(IRAK1)

PDIC:

114505021(IRAK1)

PHAS:

123823090(IRAK1)

MMF:	118636423(IRAK1)

PPAM:

129074364(IRAK1)

HAI:	109394352(IRAK1)

RFQ:	117026337(IRAK1)

PALE:

102894152(IRAK1)

PGIG:

120605933(IRAK1)

PVP:	105302526(IRAK1) 105310642

RAY:	107517734(IRAK1)

MJV:	108409511(IRAK1)

TOD:	119245797(IRAK1)

SARA:

101539504(IRAK1)

SFUM:

130017914(IRAK1)

SETR:

125999355(IRAK1)

LAV:	100676181(IRAK1)

TMU:

101350273

ETF:	101652271(IRAK1)

DNM:	101419116(IRAK1)

MDO:	100029477(IRAK1)

GAS:	123253855(IRAK1)

SHR:	100923900(IRAK1)

AFZ:

127542305

PCW:	110201533(IRAK1)

PBRV:

138177309(IRAK1)

MLAO:

141503224(IRAK1)

OAA:	100077683(IRAK1)

TACU:

119929556(IRAK1)

BBUT:

142025799(IRAK1)

CBOR:

142074253(IRAK1)

CBOY:

140645499(IRAK1)

MAME:

142404125(IRAK1)

ASN:	102374837(IRAK1)

AMJ:	102575313(IRAK1)

CIZ:	142024713(IRAK1)

CCAY:

125628318(IRAK1)

LKP:	140902015(IRAK1)

NDS:	141976213(IRAK1)

DCC:	119847060(IRAK1)

CPIC:

101937579(IRAK1)

CABI:

116823162(IRAK1)

MRV:	120388499(IRAK1)

EMQ:	137149647(IRAK1)

ACS:	100563977(irak1)

ASAO:

132767845(IRAK1)

PVT:	110078665(IRAK1)

SUND:

121920505(IRAK1)

PBI:	103047962(IRAK1)

PMUR:

107284218(IRAK1)

CTIG:

120301423(IRAK1)

TSR:	106543646(IRAK1)

PGUT:

117675517(IRAK1)

PCAE:

139312939(IRAK1)

APRI:

131191609(IRAK1)

PTEX:

113443218(IRAK1)

NSS:	113417693(IRAK1)

VKO:	123029999(IRAK1)

PMUA:

114587380(IRAK1)

PRAF:

128404699(IRAK1)

ZVI:	118097632(IRAK1)

HCG:	128345644(IRAK1)

GJA:	107108391(IRAK1)

EMC:	129346112(IRAK1)

XLA:	108700006 108704503(irak1.L)

XTR:	448357(irak1)

NPR:	108790442(IRAK1)

RTEM:

120913180(IRAK1)

ACAT:

141108546(IRAK1)

PADS:

140344328(IRAK1)

BBUF:

120977221(IRAK1)

BGAR:

122919839(IRAK1)

DTC:	141101623(IRAK1)

PWL:	138260934(IRAK1)

MUO:	115463523(IRAK1)

GSH:	117349187(IRAK1)

DRE:	569226(irak1)

DAES:

130234169(irak1)

SRX:	107743109(irak1)

SANH:

107674316 107701821

SGH:	107552214(irak1) 107584912

CCAR:

109070023 109102567

CAUA:

113080116 113081324 113107031

CGIB:

127963831 128018965

PTET:

122350483(irak1)

LROH:

127169561(irak1)

GRF:	141287331(irak1)

OMC:	131546124(irak1)

PPRM:

120475052(irak1)

RKG:	130099539(irak1)

MAMB:

125279927(irak1)

CIDE:

127517057

CERY:

137026848(irak1)

MASI:

127415026 127424428

TROS:

130568587(irak1)

TDW:	130407154(irak1)

MANU:

129415105(irak1)

PDAB:

135751965(irak1)

IPU:

108265822

IFU:	128608186(irak1)

PHYP:

113534859(irak1)

SMEO:

124400408(irak1)

TFD:	113645811(irak1)

TVC:	132853635(irak1)

CGAR:

128530748(irak1)

NGRA:

132893385(irak1)

TRN:	134318500(irak1)

AMEX:

103044222(irak1)

CMAO:

118813884(irak1)

EEE:	113575834(irak1)

CHAR:

105899000(irak1)

SPIL:

134087702(irak1)

ASAD:

121713325(irak1)

TRU:	101061773(irak1)

TFS:	130530296(irak1)

TNG:	GSTEN00009038G001

LCO:

104935488

EMAC:

134863264(irak1)

ELY:	117257772(irak1)

EFO:	125891925(irak1)

PLEP:

121946647(irak1)

SLUC:

116045451(irak1)

PFLV:

114559390

GAT:	120814955(irak1)

PPUG:

119221828(irak1)

AFB:	129088922(irak1)

CLUM:

117733039(irak1)

PSWI:

130200188(irak1)

CANA:

137801185(irak1)

CVE:	137888735(irak1)

MSAM:

119905524(irak1)

SCHU:

122882853(irak1)

EARM:

139288606(irak1)

CUD:	121517968(irak1)

SPUL:

138608214(irak1)

LMIX:

132990274(irak1)

HTC:	141799303(irak1)

ALAT:

119023059(irak1)

ASTR:

137605896(irak1)

PKLU:

139210211(irak1)

MZE:	101465239(irak1)

ONL:	100703930(irak1)

OAU:	116335454(irak1)

OLA:

101166698

OML:	112159797(irak1)

CSAI:

133456971(irak1)

XMA:	102231075(irak1)

XCO:

114140233

XHE:

116722873

PFOR:

103131931(irak1)

PLAI:

106936405(irak1)

PMEI:

106909765(irak1)

GAF:	122840396(irak1)

PPRL:

129354469

CVG:	107099142(irak1)

CTUL:

119792011(irak1)

GMU:	124875456(irak1)

NFU:	107391452(irak1)

KMR:	108228236(irak1)

ALIM:

106511233

NWH:

119417405

LTU:	140272473(irak1)

AOCE:

111585594(irak1)

EJA:	138215556(irak1)

BFRE:

138631550(irak1)

MCEP:

125008809(irak1)

CSEM:

103384394(irak1)

POV:	109645801(irak1)

SSEN:

122777877(irak1)

SSOE:

131469258(irak1)

HHIP:

117765234(irak1)

HSP:	118111658(irak1)

PPLT:

128442943(irak1)

SMAU:

118316923(irak1)

LCF:

108890558

SDU:	111235426(irak1)

SLAL:

111654973(irak1)

XGL:	120803823(irak1)

HCQ:	109529353(irak1)

SBIA:

133493043(irak1)

PEE:	133411351(irak1)

PTAO:

133465152(irak1)

BPEC:

110154469(irak1)

ENY:	140363080(irak1)

MALB:

109967881(irak1)

BSPL:

114858597(irak1)

SJO:	128357703(irak1)

SSCO:

133987978(irak1)

GMH:

115540234

SASA:

106566344

STRU:

115168732(irak1)

OTW:	112238306(irak1)

OMY:	110492704(irak1)

OGO:	124045391(irak1)

ONE:

115121977

OKI:	109869102(irak1)

OKE:	118377759(irak1)

OMM:	135527685(irak1)

OCLA:

139369007

SALP:

112072310

SNH:	120061459(irak1)

SFON:

129861357(irak1)

CCLU:

121546177(irak1)

ELS:	105028326(irak1)

OEP:	134019191(irak1)

SFM:	108934844(irak1)

PKI:	111856149(irak1)

AANG:

118208465(irak1)

AROT:

135235257(irak1)

CCOG:

133138575(irak1)

LOC:	102698319(irak1)

PSPA:

121328847(irak1)

ARUT:

117404204

LCM:	102359430(IRAK1)

CMK:

103176741

CPLA:

122542363(irak1)

CPUN:

140470034(irak1)

HOC:	132809056(irak1) 132822165

LERI:

129704564 129716210(irak1)

HAKA:

140715547(irak1) 140741924

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SPU:

APLC:

ARUN:

SKO:

DME:	Dmel_CG5974(pll)

DER:

6554685

DSE:

6617161

DSI:	Dsimw501_GD28088(Dsim_GD28088)

DYA:	Dyak_GE10573(Dyak_pll)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22298

DAZ:

108620820

DNV:

115564094

DHE:

111597872

DVI:	6633066(pll)

CCAT:

101455742

BOD:	106622098(pll)

BDR:

105223214

AOQ:

129246553

ALUD:

128865772

TDA:	119677403 119679727 119680991

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135961145(pll)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

109415475 115264543 115264679

ASUA:

134213201 134219724

CQU:	CpipJ_CPIJ015474

CPII:

120430395

CBRI:

134838267

CNS:	116346693 116348769 116348880

BCOO:

119080038

LLL:	129794627 129797017

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108730152(pll)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139103599(Pll)

TLN:	139811966(Pll)

TAME:

143899605(Pll)

HST:

DQU:

CFO:

FEX:

PMEC:

138933920(Pll)

LHU:	105671849(pll)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100115010 100116695

CSOL:

105359643

TPRE:

106651056

LHT:	122502513 122505390

LBD:

127290701

MDL:

103578198

CGLO:

123261525

CTYP:

141534537(Pll)

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:	124409880 124412115

NPT:	124217333 124222041(pll)

NFB:	124180733 124184206

NLO:	107218393 107220334

NVG:	124302896 124306612

AROA:

105685197 105685261

TCA:	654877(IL-1)

TMOL:

138128435(pll)

DPA:

109537660

ESIM:

136411395

EFOR:

136349292(pll)

SOY:

115877325

RFG:	143203795(pll)

AGRG:

126739249

ATD:	109599082 109601470

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210260A

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137925984(pll)

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:	124641860 124641980

TNL:

SLIU:

ONU:

ATRA:

GMW:

ECLR:

140746741(pll)

PXY:

PGW:

CFUM:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

NLU:

LDA:	142321908(pll)

HVI:	124360702 124371214

MQU:

128991957

PHU:	Phum_PHUM518290

FOC:

TPAL:

ZNE:

CSEC:

PAME:

BROR:

HAMR:

139700199(pll)

FCD:

110858699

DPX:	DAPPUDRAFT_331814

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

MRJ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

DALB:

RSAN:

RMP:	119174712 142817728

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CVS:

PTEP:

ABRU:

UDV:

SDM:	118189245 118189249

CEL:	CELE_K09B11.1(pik-1)

CBR:	CBG_01770(Cbr-pik-1)

NAI:	NECAME_08104

BMY:	BM_BM4945(Bma-pik-1)

LOA:	LOAG_07622

CRG:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

Reference

PMID:11397809

Authors

Jensen LE, Whitehead AS

Title

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.

Journal

J Biol Chem 276:29037-44 (2001)
DOI:10.1074/jbc.M103815200

Sequence

[hsa:3654]

LinkDB

ORTHOLOGY: K04731

Entry

K04731                      KO

Symbol

IRAK2

Name

interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]

Pathway

map04722

Neurotrophin signaling pathway

map05152

Tuberculosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04731  IRAK2; interleukin-1 receptor-associated kinase 2
09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K04731  IRAK2; interleukin-1 receptor-associated kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04731  IRAK2; interleukin-1 receptor-associated kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04731  IRAK2; interleukin-1 receptor-associated kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  IRAK family
   K04731  IRAK2; interleukin-1 receptor-associated kinase 2

Genes

HSA:	3656(IRAK2)

PTR:	460165(IRAK2)

PPS:	100986617(IRAK2)

GGO:	101127688(IRAK2)

PON:	100454140(IRAK2)

PPYG:

129033207(IRAK2)

NLE:	100579496(IRAK2)

HMH:	116466544(IRAK2)

SSYN:

129471643(IRAK2)

MCC:	698091(IRAK2)

MCF:	102135140(IRAK2)

MTHB:

126947713

MNI:	105477691(IRAK2)

CSAB:

103228653(IRAK2)

CATY:

105585776(IRAK2)

PANU:

101025226(IRAK2)

TGE:	112618865(IRAK2)

MLEU:

105549539(IRAK2)

RRO:	104667142(IRAK2)

RBB:	108512268(IRAK2)

TFN:	117083241(IRAK2)

PTEH:

111546931(IRAK2)

CANG:

105519079(IRAK2)

CJC:	100403619(IRAK2)

SBQ:	101035769(IRAK2)

CIMI:

108284660(IRAK2)

ANAN:

105731306(IRAK2)

CSYR:

103262037(IRAK2)

MMUR:

105869053(IRAK2)

LCAT:

123623057(IRAK2)

ERUF:

138388279(IRAK2)

PCOQ:

105812174(IRAK2)

OGA:	100966956(IRAK2)

MMU:	108960(Irak2)

MCAL:

110296422(Irak2) 110302454

MPAH:

110316521(Irak2)

RNO:	362418(Irak2)

MCOC:

116099408(Irak2)

ANU:	117715549(Irak2)

ASYL:

127679055(Irak2)

MUN:	110548940(Irak2)

CGE:	100758629(Irak2)

MAUA:

101830137(Irak2)

PROB:

127236147(Irak2)

PLEU:

114689617(Irak2)

PMAV:

102927384(Irak2)

MORG:

121435844(Irak2)

MFOT:

126505477

AAMP:

119806955(Irak2)

CNL:	130873984(Irak2)

NGI:	103751434(Irak2)

HGL:	101697284(Irak2)

CPOC:

100728945(Irak2)

CCAN:

109688956(Irak2)

DORD:

105981248(Irak2)

DSP:	122108166(Irak2)

DMER:

138822697 138824804

PLOP:

125358785(Irak2)

NCAR:

124971223

MMMA:

107150072(Irak2)

ITI:	101956291(Irak2)

OCU:

103345503

OPI:	101531569(IRAK2)

OCZ:	121166101(IRAK2)

TUP:	102500857(IRAK2)

GVR:

103610945

CFA:	484657(IRAK2)

CLUD:

112661873(IRAK2)

VVP:	112933707(IRAK2)

VLG:	121496058(IRAK2)

NPO:	129522508(IRAK2)

AML:	100468615(IRAK2)

UMR:	103669562(IRAK2)

UAH:	113257163(IRAK2)

UAR:	123799205(IRAK2)

ELK:

111144038

LLV:

125108718

MPUF:

101680607(IRAK2)

MNP:	132009886(IRAK2)

MLK:	131824217(IRAK2)

NVS:	122909211(IRAK2)

ORO:	101369863(IRAK2)

EJU:	114207676(IRAK2)

ZCA:	113917779(IRAK2)

MLX:	118004873(IRAK2)

MANO:

123833563(IRAK2)

NSU:	110584816(IRAK2)

LWW:	102739305(IRAK2)

FCA:	101086888(IRAK2)

PYU:	121041269(IRAK2)

PCOO:

112857889(IRAK2)

PBG:	122487497(IRAK2)

PVIV:

125161096(IRAK2)

LRUF:

124523766

LGF:	123605965(IRAK2)

AJU:

106972373

PTG:	102964669(IRAK2)

PPAD:

109254367(IRAK2)

PUC:

125929630

PLEZ:

122203723(IRAK2)

HHV:	120231341(IRAK2)

CCRU:

144221121(IRAK2)

BTA:	515034(IRAK2)

BOM:	102264912(IRAK2)

BIU:	109576286(IRAK2)

BJV:

133235143

BBUB:

102411331(IRAK2)

BKE:	129635432(IRAK2)

BBIS:

104990147(IRAK2)

CHX:	102180544(IRAK2)

OAS:	101122222(IRAK2)

OCAN:

138424828(IRAK2)

BTAX:

128049655(IRAK2)

CSUM:

138087405(IRAK2)

ODA:	120867721(IRAK2)

CCAD:

122424432(IRAK2)

MREE:

136166624(IRAK2)

OVR:	110133519(IRAK2)

MBEZ:

129548074(IRAK2)

SSC:	106505672(IRAK2)

CFR:	102513370(IRAK2)

CBAI:

105067455(IRAK2)

CDK:	105093117(IRAK2)

VPC:	102526122(IRAK2)

BACU:

103006452(IRAK2)

BMUS:

118903878(IRAK2)

LVE:	103080836(IRAK2)

OOR:	101273127(IRAK2)

LALB:

132526799(IRAK2)

GMF:	115844043(IRAK2)

DDP:	132432508(IRAK2)

DLE:	111169948(IRAK2)

PCAD:

102996764(IRAK2)

PSIU:

116762787(IRAK2)

PPHC:

136129201(IRAK2)

NASI:

112412932(IRAK2)

ECB:	100058093(IRAK2)

EPZ:	103561462(IRAK2)

EAI:	106835624(IRAK2)

MYB:	102262595(IRAK2)

MYD:	102765283(IRAK2)

MMYO:

118668055(IRAK2)

MLF:	102422936(IRAK2)

MDT:	132215380(IRAK2)

MYUM:

139022457(IRAK2)

PKL:	118715199(IRAK2)

EFUS:

103295537(IRAK2)

MNA:	107534744(IRAK2)

DRO:	112301234(IRAK2)

SHON:

118993332(IRAK2)

AJM:	119038337(IRAK2)

PDIC:

114501671(IRAK2)

PHAS:

123814442(IRAK2)

MMF:	118633377(IRAK2)

PPAM:

129087944(IRAK2)

HAI:	109387293(VHL)

RFQ:	117037303(IRAK2)

PALE:

102890828(IRAK2)

PGIG:

120621457(IRAK2)

PVP:	105299033(IRAK2)

RAY:	107498358(IRAK2)

MJV:

108408138

TOD:	119255473(IRAK2)

SARA:

101537853(IRAK2)

SFUM:

130037789(IRAK2)

SETR:

125997926(IRAK2)

LAV:	100658954(IRAK2)

TMU:

101352317

ETF:	101639521(IRAK2)

DNM:	101429286(IRAK2)

MDO:	100024326(IRAK2)

GAS:	123247197(IRAK2)

SHR:	100932591(IRAK2)

AFZ:

127551904

PCW:	110204866(IRAK2)

TVP:	118831401(IRAK2)

PBRV:

138158070(IRAK2)

MLAO:

141496253(IRAK2)

OAA:	100090992(IRAK2)

TACU:

119919442(IRAK2)

GGA:	416118(IRAK2)

PCOC:

116236593(IRAK2)

MGP:	100544771(IRAK2)

CJO:

TPAI:

LMUT:

NMEL:

APLA:

101796415(IRAK2)

AACU:

137862222(IRAK2)

OJA:	118173131(IRAK2)

ACYG:

106036772(IRAK2)

CATA:

118248075(IRAK2)

AFUL:

116493083

TGU:	100228175(IRAK2)

LSR:	110477116(IRAK2)

SCAN:

103824139(IRAK2)

PMOA:

120495644(IRAK2)

OTC:	121347389(IRAK2)

PRUF:

121352026(IRAK2)

ATRC:

139595718(IRAK2)

GFR:	102031963(IRAK2)

FAB:	101818470(IRAK2)

OMA:	130258100(IRAK2)

PHI:	102106109(IRAK2)

PMAJ:

107210251(IRAK2)

CCAE:

111934911(IRAK2)

CCW:

104683521

CBRC:

103616325

ACOE:

138117334(IRAK2)

ETL:

114067681

ZAB:	102062604(IRAK2)

ZLE:	135453376(IRAK2)

ACHL:

103809418(IRAK2)

SVG:	106851786(IRAK2)

MMEA:

130583620 130585468

HRT:	120758464(IRAK2)

SATI:

136366217(IRAK2)

CCIC:

134048709(IRAK2)

FPG:	101922091(IRAK2)

FCH:

102057703

CCRI:

104165415(IRAK2)

NNT:	104402463(IRAK2)

SHAB:

115614317(IRAK2)

ACUN:

113484726

TALA:

104368614(IRAK2)

ACHC:

115353860(IRAK2)

HALD:

104323924(IRAK2)

HLE:	104833548(IRAK2)

AGEN:

126049960

HHAR:

128136581(IRAK2)

BBUT:

142042767(IRAK2)

GCL:

127021738

CSTI:

104555690

LDI:	104355005(IRAK2)

MNB:

103773584

DPUB:

104303438

PPUS:

135182260(IRAK2)

AVIT:

104267111

BRHI:

104493751(IRAK2)

EGZ:	104121773(IRAK2)

NNI:	104016955(IRAK2)

PCRI:

104038602

PCAO:

104047457

PARX:

142058425(IRAK2)

PADL:

103913595(IRAK2)

AFOR:

103902654(IRAK2)

FGA:	104080625(IRAK2)

CBOR:

142086063(IRAK2)

GSTE:

104257231(IRAK2)

CBOY:

140657880(IRAK2)

MAME:

142415769(IRAK2)

CLV:	102086676(IRAK2)

CNIC:

135992982(IRAK2)

MUI:

104536049

PGUU:

104470927(IRAK2)

PLET:

104614733

EHS:	104514246(IRAK2)

CMAC:

104479489

CUCA:

104063593(IRAK2)

TEO:	104382308(IRAK2)

BREG:

104639721

GAME:

129211432(IRAK2)

OHA:

104334374

ACAR:

104521246

CPEA:

104393837

CVF:	104284524(IRAK2)

RTD:	128915569(IRAK2)

CRID:

134521566(IRAK2)

LMIC:

141749440(IRAK2)

AAM:	106494624(IRAK2)

AROW:

112970512(IRAK2)

NPD:	112958659(IRAK2)

TGT:	104571462(IRAK2)

DNE:	112982920(IRAK2)

SCAM:

104148136(IRAK2)

ASN:	102373890(IRAK2)

AMJ:	102557926(IRAK2)

CPOO:

109311133(IRAK2)

GGN:	109288930(IRAK2)

PSS:	102445924(IRAK2)

CIZ:	142019024(IRAK2)

CMY:	102930051(IRAK2)

CCAY:

125640132(IRAK2)

LKP:	140914120(IRAK2)

NDS:	141990418(IRAK2)

DCC:	119859187(IRAK2)

CPIC:

101936513(IRAK2)

TST:	117879983(IRAK2)

CABI:

116827060(IRAK2)

MRV:	120409379(IRAK2)

EMQ:	137150425(IRAK2)

ACS:	100560723(irak2)

ASAO:

132769367(IRAK2)

PVT:	110077870(IRAK2)

SUND:

121922871(IRAK2)

PBI:	103052971(IRAK2)

PMUR:

107297847(IRAK2) 107300948

CTIG:

120319525(IRAK2)

TSR:	106543211(IRAK2)

PGUT:

117673908(IRAK2)

PCAE:

139309503(IRAK2)

APRI:

131190832(IRAK2)

PTEX:

113451387(IRAK2)

NSS:	113419335(IRAK2)

VKO:	123034130(IRAK2)

PMUA:

114591792(IRAK2)

PRAF:

128408416(IRAK2)

ZVI:	118080789(IRAK2)

HCG:	128347829(IRAK2)

GJA:	107122201(IRAK2)

STOW:

125430105(IRAK2)

EMC:	129327472(IRAK2)

XLA:	108715855(vhl.S) 379176(irak2.L)

XTR:	493227(irak2)

NPR:	108786038(IRAK2)

RTEM:

120946165

ACAT:

141102761(IRAK2)

PADS:

140336988(IRAK2)

BBUF:

120978598(IRAK2)

BGAR:

122943204(IRAK2)

DTC:	141088778(IRAK2) 141088779

PWL:	138258970(IRAK2)

MUO:

115472469

PSPA:

121298250

ARUT:

117411730

LCM:	102363245(IRAK2)

CPLA:

CPUN:

SCAU:

Reference

PMID:12620219

Authors

Janssens S, Beyaert R

Title

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members.

Journal

Mol Cell 11:293-302 (2003)
DOI:10.1016/S1097-2765(03)00053-4

Reference

PMID:9374458

Authors

Muzio M, Ni J, Feng P, Dixit VM

Title

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

Journal

Science 278:1612-5 (1997)
DOI:10.1126/science.278.5343.1612

Sequence

[hsa:3656]

LinkDB

DBGET integrated database retrieval system