ORTHOLOGY: K04735
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Entry
K04735 KO
Symbol
RELA
Name
transcription factor p65
Pathway
map01523
Antifolate resistance
map04010
MAPK signaling pathway
map04014
Ras signaling pathway
map04024
cAMP signaling pathway
map04062
Chemokine signaling pathway
map04064
NF-kappa B signaling pathway
map04066
HIF-1 signaling pathway
map04071
Sphingolipid signaling pathway
map04137
Mitophagy - animal
map04151
PI3K-Akt signaling pathway
map04210
Apoptosis
map04211
Longevity regulating pathway
map04218
Cellular senescence
map04380
Osteoclast differentiation
map04613
Neutrophil extracellular trap formation
map04620
Toll-like receptor signaling pathway
map04621
NOD-like receptor signaling pathway
map04622
RIG-I-like receptor signaling pathway
map04623
Cytosolic DNA-sensing pathway
map04625
C-type lectin receptor signaling pathway
map04657
IL-17 signaling pathway
map04658
Th1 and Th2 cell differentiation
map04659
Th17 cell differentiation
map04660
T cell receptor signaling pathway
map04662
B cell receptor signaling pathway
map04668
TNF signaling pathway
map04722
Neurotrophin signaling pathway
map04917
Prolactin signaling pathway
map04920
Adipocytokine signaling pathway
map04926
Relaxin signaling pathway
map04931
Insulin resistance
map04932
Non-alcoholic fatty liver disease
map04933
AGE-RAGE signaling pathway in diabetic complications
map04936
Alcoholic liver disease
map05010
Alzheimer disease
map05022
Pathways of neurodegeneration - multiple diseases
map05030
Cocaine addiction
map05120
Epithelial cell signaling in Helicobacter pylori infection
map05130
Pathogenic Escherichia coli infection
map05131
Shigellosis
map05132
Salmonella infection
map05133
Pertussis
map05134
Legionellosis
map05135
Yersinia infection
map05140
Leishmaniasis
map05142
Chagas disease
map05145
Toxoplasmosis
map05146
Amoebiasis
map05152
Tuberculosis
map05160
Hepatitis C
map05161
Hepatitis B
map05162
Measles
map05163
Human cytomegalovirus infection
map05164
Influenza A
map05165
Human papillomavirus infection
map05166
Human T-cell leukemia virus 1 infection
map05167
Kaposi sarcoma-associated herpesvirus infection
map05168
Herpes simplex virus 1 infection
map05169
Epstein-Barr virus infection
map05170
Human immunodeficiency virus 1 infection
map05171
Coronavirus disease - COVID-19
map05200
Pathways in cancer
map05202
Transcriptional misregulation in cancer
map05203
Viral carcinogenesis
map05207
Chemical carcinogenesis - receptor activation
map05208
Chemical carcinogenesis - reactive oxygen species
map05212
Pancreatic cancer
map05215
Prostate cancer
map05220
Chronic myeloid leukemia
map05221
Acute myeloid leukemia
map05222
Small cell lung cancer
map05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321
Inflammatory bowel disease
map05415
Diabetic cardiomyopathy
map05417
Lipid and atherosclerosis
map05418
Fluid shear stress and atherosclerosis
Disease
H02593
Chronic mucocutaneous ulceration
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K04735 RELA; transcription factor p65
04014 Ras signaling pathway
K04735 RELA; transcription factor p65
04064 NF-kappa B signaling pathway
K04735 RELA; transcription factor p65
04668 TNF signaling pathway
K04735 RELA; transcription factor p65
04066 HIF-1 signaling pathway
K04735 RELA; transcription factor p65
04071 Sphingolipid signaling pathway
K04735 RELA; transcription factor p65
04024 cAMP signaling pathway
K04735 RELA; transcription factor p65
04151 PI3K-Akt signaling pathway
K04735 RELA; transcription factor p65
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
K04735 RELA; transcription factor p65
09143 Cell growth and death
04210 Apoptosis
K04735 RELA; transcription factor p65
04218 Cellular senescence
K04735 RELA; transcription factor p65
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
K04735 RELA; transcription factor p65
04620 Toll-like receptor signaling pathway
K04735 RELA; transcription factor p65
04621 NOD-like receptor signaling pathway
K04735 RELA; transcription factor p65
04622 RIG-I-like receptor signaling pathway
K04735 RELA; transcription factor p65
04623 Cytosolic DNA-sensing pathway
K04735 RELA; transcription factor p65
04625 C-type lectin receptor signaling pathway
K04735 RELA; transcription factor p65
04660 T cell receptor signaling pathway
K04735 RELA; transcription factor p65
04658 Th1 and Th2 cell differentiation
K04735 RELA; transcription factor p65
04659 Th17 cell differentiation
K04735 RELA; transcription factor p65
04657 IL-17 signaling pathway
K04735 RELA; transcription factor p65
04662 B cell receptor signaling pathway
K04735 RELA; transcription factor p65
04062 Chemokine signaling pathway
K04735 RELA; transcription factor p65
09152 Endocrine system
04920 Adipocytokine signaling pathway
K04735 RELA; transcription factor p65
04917 Prolactin signaling pathway
K04735 RELA; transcription factor p65
04926 Relaxin signaling pathway
K04735 RELA; transcription factor p65
09156 Nervous system
04722 Neurotrophin signaling pathway
K04735 RELA; transcription factor p65
09158 Development and regeneration
04380 Osteoclast differentiation
K04735 RELA; transcription factor p65
09149 Aging
04211 Longevity regulating pathway
K04735 RELA; transcription factor p65
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04735 RELA; transcription factor p65
05202 Transcriptional misregulation in cancer
K04735 RELA; transcription factor p65
05207 Chemical carcinogenesis - receptor activation
K04735 RELA; transcription factor p65
05208 Chemical carcinogenesis - reactive oxygen species
K04735 RELA; transcription factor p65
05203 Viral carcinogenesis
K04735 RELA; transcription factor p65
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
K04735 RELA; transcription factor p65
09162 Cancer: specific types
05212 Pancreatic cancer
K04735 RELA; transcription factor p65
05221 Acute myeloid leukemia
K04735 RELA; transcription factor p65
05220 Chronic myeloid leukemia
K04735 RELA; transcription factor p65
05215 Prostate cancer
K04735 RELA; transcription factor p65
05222 Small cell lung cancer
K04735 RELA; transcription factor p65
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
K04735 RELA; transcription factor p65
05170 Human immunodeficiency virus 1 infection
K04735 RELA; transcription factor p65
05161 Hepatitis B
K04735 RELA; transcription factor p65
05160 Hepatitis C
K04735 RELA; transcription factor p65
05171 Coronavirus disease - COVID-19
K04735 RELA; transcription factor p65
05164 Influenza A
K04735 RELA; transcription factor p65
05162 Measles
K04735 RELA; transcription factor p65
05168 Herpes simplex virus 1 infection
K04735 RELA; transcription factor p65
05163 Human cytomegalovirus infection
K04735 RELA; transcription factor p65
05167 Kaposi sarcoma-associated herpesvirus infection
K04735 RELA; transcription factor p65
05169 Epstein-Barr virus infection
K04735 RELA; transcription factor p65
05165 Human papillomavirus infection
K04735 RELA; transcription factor p65
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
K04735 RELA; transcription factor p65
05130 Pathogenic Escherichia coli infection
K04735 RELA; transcription factor p65
05132 Salmonella infection
K04735 RELA; transcription factor p65
05131 Shigellosis
K04735 RELA; transcription factor p65
05135 Yersinia infection
K04735 RELA; transcription factor p65
05133 Pertussis
K04735 RELA; transcription factor p65
05134 Legionellosis
K04735 RELA; transcription factor p65
05152 Tuberculosis
K04735 RELA; transcription factor p65
09174 Infectious disease: parasitic
05146 Amoebiasis
K04735 RELA; transcription factor p65
05145 Toxoplasmosis
K04735 RELA; transcription factor p65
05140 Leishmaniasis
K04735 RELA; transcription factor p65
05142 Chagas disease
K04735 RELA; transcription factor p65
09163 Immune disease
05321 Inflammatory bowel disease
K04735 RELA; transcription factor p65
09164 Neurodegenerative disease
05010 Alzheimer disease
K04735 RELA; transcription factor p65
05022 Pathways of neurodegeneration - multiple diseases
K04735 RELA; transcription factor p65
09165 Substance dependence
05030 Cocaine addiction
K04735 RELA; transcription factor p65
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
K04735 RELA; transcription factor p65
05418 Fluid shear stress and atherosclerosis
K04735 RELA; transcription factor p65
05415 Diabetic cardiomyopathy
K04735 RELA; transcription factor p65
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
K04735 RELA; transcription factor p65
04932 Non-alcoholic fatty liver disease
K04735 RELA; transcription factor p65
04931 Insulin resistance
K04735 RELA; transcription factor p65
04933 AGE-RAGE signaling pathway in diabetic complications
K04735 RELA; transcription factor p65
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
K04735 RELA; transcription factor p65
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors
K04735 RELA; transcription factor p65
Transcription factors [BR:
ko03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
RHR (Rel homology region) Rel/Ankyrin
K04735 RELA; transcription factor p65
BRITE hierarchy
Genes
HSA:
5970
(RELA)
PTR:
466665
(RELA)
PPS:
100988429
(RELA)
GGO:
101150285
(RELA)
PON:
100456049
(RELA)
PPYG:
129008417
(RELA)
NLE:
100588439
(RELA)
HMH:
116469011
(RELA)
SSYN:
129469920
(RELA)
MCC:
715919
(RELA)
MCF:
101867324
(RELA)
MTHB:
126935358
MNI:
105469585
(RELA)
CSAB:
103227364
(RELA)
CATY:
105577432
(RELA)
PANU:
101017078
(RELA)
TGE:
112605794
(RELA)
MLEU:
105528449
(RELA)
RRO:
104664815
(RELA)
RBB:
108543519
(RELA)
TFN:
117081405
(RELA)
PTEH:
111522422
(RELA)
CANG:
105512156
(RELA)
CJC:
100388493
(RELA)
SBQ:
101035406
(RELA)
CIMI:
108310400
(RELA)
ANAN:
105724416
(RELA)
CSYR:
103252103
(RELA)
MMUR:
105878531
(RELA)
LCAT:
123641353
(RELA)
PCOQ:
105827383
(RELA)
OGA:
100957990
(RELA)
MMU:
19697
(Rela)
MCAL:
110285703
(Rela)
MPAH:
110317041
(Rela)
RNO:
309165
(Rela)
MCOC:
116103403
(Rela)
ANU:
117722582
(Rela)
MUN:
110549347
(Rela)
CGE:
100763542
(Rela)
MAUA:
101831177
(Rela)
PROB:
127228707
(Rela)
PLEU:
114682099
(Rela)
MORG:
121454688
(Rela)
MFOT:
126498562
AAMP:
119803437
(Rela)
NGI:
103724994
(Rela)
HGL:
101716738
(Rela)
CPOC:
100724366
(Rela)
CCAN:
109687142
(Rela)
DORD:
105989242
(Rela)
DSP:
122105094
(Rela)
PLOP:
125361933
(Rela)
NCAR:
124960546
MMMA:
107156942
(Rela)
OCU:
127485184
OPI:
101530066
(RELA)
TUP:
102490451
(RELA)
GVR:
103595334
(RELA)
CFA:
483729
(RELA)
CLUD:
112659193
(RELA)
VVP:
112924254
(RELA)
VLG:
121471268
(RELA)
NPO:
129503049
(RELA)
AML:
100480158
(RELA)
UMR:
103679584
(RELA)
UAH:
113244102
(RELA)
UAR:
123778302
(RELA)
ELK:
111149956
LLV:
125078405
MPUF:
101680239
(RELA)
MNP:
132018657
(RELA)
MLK:
131815578
(RELA)
NVS:
122913121
(RELA)
ORO:
101381225
(RELA)
EJU:
114220346
(RELA)
ZCA:
113914948
(RELA)
MLX:
118016059
(RELA)
NSU:
110575986
(RELA)
LWW:
102739707
(RELA)
FCA:
101096604
(RELA)
PYU:
121023959
(RELA)
PCOO:
112851941
(RELA)
PBG:
122484468
(RELA)
PVIV:
125176511
(RELA)
LRUF:
124504954
PTG:
102951132
(RELA)
PPAD:
109246747
(RELA)
PUC:
125912163
AJU:
106971136
HHV:
120240185
(RELA)
BTA:
508233
(RELA)
BOM:
102268417
(RELA)
BIU:
109554392
(RELA)
BBUB:
102397938
(RELA)
BBIS:
104987029
(RELA)
CHX:
102174096
(RELA)
OAS:
101102191
(RELA)
BTAX:
128068546
(RELA)
ODA:
120874649
(RELA)
CCAD:
122430633
(RELA)
MBEZ:
129548767
(RELA)
SSC:
100135665
(RELA)
CFR:
102506204
(RELA)
CBAI:
105070689
(RELA)
CDK:
105102595
(RELA)
VPC:
102540197
(RELA)
BACU:
103019614
(RELA)
BMUS:
118899660
(RELA)
LVE:
103087304
(RELA)
OOR:
101270342
(RELA)
DLE:
111183745
(RELA)
PCAD:
102974198
(RELA)
PSIU:
116758150
(RELA)
NASI:
112402272
(RELA)
ECB:
100057483
(RELA)
EPZ:
103543692
(RELA)
EAI:
106833569
(RELA)
MYB:
102263790
(RELA)
MYD:
102770704
(RELA)
MMYO:
118665292
(RELA)
MLF:
102424236
(RELA)
MDT:
132241412
(RELA)
PKL:
118706879
(RELA)
EFUS:
103291087
(RELA)
MNA:
107533544
(RELA)
DRO:
112317202
(RELA)
SHON:
118991736
(RELA)
AJM:
119050282
(RELA)
PDIC:
114499888
(RELA)
PHAS:
123829518
(RELA)
MMF:
118628367
(RELA)
PPAM:
129068571
(RELA)
HAI:
109384322
(RELA)
RFQ:
117030742
(RELA)
PALE:
102878395
(RELA)
PGIG:
120584840
(RELA)
PVP:
105297999
(RELA)
RAY:
107497522
(RELA)
MJV:
108397005
(RELA)
TOD:
119248814
(RELA)
SARA:
101543163
(RELA)
SETR:
126019025
(RELA)
LAV:
100654730
(RELA)
TMU:
101361706
ETF:
101663870
(RELA)
DNM:
101417885
(RELA)
MDO:
100030053
(RELA)
GAS:
123251290
(RELA)
SHR:
100932473
(RELA)
AFZ:
127540746
PCW:
110195563
(RELA)
TVP:
118853831
(RELA)
OAA:
100074633
(RELA)
GGA:
396027
(RELA)
CJO:
107307430
TGU:
115492066
(RELA)
LSR:
110478845
(RELA)
PMOA:
120507316
(RELA)
OTC:
121340600
(RELA)
OMA:
130262766
(RELA)
PHI:
102105891
(RELA)
CCW:
120412318
ZLE:
135460342
(RELA)
SVG:
106863554
(RELA)
HRT:
120747638
(RELA)
SHAB:
115603474
(RELA)
AGEN:
126053415
ASN:
102377458
(RELA)
AMJ:
102573364
(RELA)
PSS:
102457804
(RELA)
CMY:
102947354
(RELA)
CCAY:
125639301
(RELA)
DCC:
119858230
(RELA)
CPIC:
101933001
(RELA)
TST:
117880425
(RELA)
CABI:
116838783
(RELA)
MRV:
120369204
(RELA)
ACS:
100556163
(rela)
ASAO:
132764274
(RELA)
PVT:
110069799
(RELA)
SUND:
121915610
(RELA)
PBI:
103050942
(RELA)
PMUR:
107297118
(RELA)
CTIG:
120318476
(RELA)
TSR:
106556843
(RELA)
PGUT:
117669743
(RELA)
APRI:
131186557
(RELA)
PTEX:
113446671
(RELA)
VKO:
123032554
(RELA)
PMUA:
114587106
(RELA)
PRAF:
128404292
(RELA)
ZVI:
118075687
(RELA)
HCG:
128337178
(RELA)
GJA:
107115220
(RELA)
STOW:
125443366
(RELA)
EMC:
129336549
(RELA)
XLA:
108715128
(rela.S)
394353
(rela.L)
XTR:
407869
(rela)
NPR:
108784114
(RELA)
RTEM:
120917518
(RELA)
BBUF:
120980391
(RELA)
BGAR:
122920347
(RELA)
MUO:
115480195
(RELA)
GSH:
117365803
(RELA)
DRE:
415099
(rela)
SRX:
107714883
107748028
SANH:
107656774
107670401
SGH:
107573921
107574010
(rela)
CAUA:
113080235
113083585
113093139
113105396
CGIB:
127962241
128017485
PTET:
122349211
(rela)
LROH:
127167944
(rela)
OMC:
131543637
(rela)
PPRM:
120492169
(rela)
RKG:
130071070
(rela)
MAMB:
125264241
(rela)
CIDE:
127515912
CERY:
137030508
(rela)
MASI:
127410534
TROS:
130550267
(rela)
TDW:
130417861
(rela)
MANU:
129453986
(rela)
IPU:
108260779
(rela)
IFU:
128604481
(rela)
PHYP:
113545743
SMEO:
124381416
(rela)
TFD:
113635428
(rela)
TVC:
132841752
(rela)
TRN:
134326502
(rela)
AMEX:
103032041
(rela)
CMAO:
118816672
(rela)
EEE:
113584194
CHAR:
105903142
(rela)
TRU:
101073743
TFS:
130522378
(rela)
TNG:
GSTEN00000890G001
GSTEN00001997G001
GSTEN00005456G001
LCO:
109141199
NCC:
104965780
(rela)
TBEN:
117487719
(rela)
CGOB:
115023463
PGEO:
117463457
(rela)
GACU:
117542722
(rela)
EMAC:
134875789
(rela)
ELY:
117246128
(rela)
EFO:
125883512
(rela)
PLEP:
121961933
(rela)
SLUC:
116036053
(rela)
ECRA:
117934772
(rela)
ESP:
116707180
PFLV:
114545913
GAT:
120821327
(rela)
PPUG:
119222459
(rela)
AFB:
129093238
(rela)
CLUM:
117747396
(rela)
PSWI:
130211483
(rela)
MSAM:
119911844
(rela)
SCHU:
122870615
(rela)
CUD:
121504461
(rela)
ALAT:
119027261
(rela)
MZE:
101487989
(rela)
ONL:
100707676
(rela)
OAU:
116335817
(rela)
OLA:
101158728
OML:
112155860
(rela)
CSAI:
133419990
(rela)
XMA:
102219636
XCO:
114157395
XHE:
116732698
PRET:
103480184
PFOR:
103140625
PLAI:
106938010
PMEI:
106907458
GAF:
122820524
(rela)
PPRL:
129378345
(rela)
CVG:
107082800
(rela)
CTUL:
119772111
(rela)
GMU:
124880275
(rela)
NFU:
107376749
KMR:
108239405
(rela)
ALIM:
106523725
NWH:
119408350
(rela)
AOCE:
111582710
MCEP:
125010912
(relA)
CSEM:
103385629
POV:
109637639
SSEN:
122765911
(rela)
HHIP:
117751799
(rela)
HSP:
118102445
(rela)
PPLT:
128429778
(rela)
SMAU:
118301615
(rela)
LCF:
108882042
SDU:
111226894
(rela)
SLAL:
111670446
(rela)
XGL:
120797026
(rela)
HCQ:
109508419
SSCV:
125982490
SBIA:
133494899
(rela)
PEE:
133397822
(rela)
PTAO:
133472326
(rela)
BPEC:
110168801
MALB:
109969432
(rela)
BSPL:
114851349
(rela)
SJO:
128383999
(rela)
SASA:
106577543
106608684
STRU:
115194158
115198165
OTW:
112214775
112260059
OMY:
110500691
110531834
OGO:
124008159
124014577
ONE:
115133625
115138159
OKI:
109897090
109906578
OKE:
118368674
118391902
SALP:
111955077
111960277
SNH:
120030357
120049602
CCLU:
121554756
121571123
ELS:
105020694
SFM:
108934391
PKI:
111851986
111855422
AANG:
118223522
(rela)
118236176
PSPA:
121310074
(rela)
ARUT:
117398684
117962714
117967842
PSEX:
120539260
PMRN:
116947258
116953924
LRJ:
133356168
133356175
133362489
BFO:
118423605
ARUN:
117292980
TDA:
119664112
GFS:
119632982
119639308
CNS:
116350474
116350481
FAS:
105269252
DAM:
107040546
AGIF:
122848214
122849362
VCAN:
122419237
AGB:
108916217
SDM:
118181923
118183540
PVUL:
126821097
BGT:
106056974
GAE:
121371239
HRF:
124144668
HRJ:
124264460
CRG:
105319044
CVN:
111130067
OSN:
115217075
» show all
Taxonomy
UniProt
Reference
PMID:
2006423
Authors
Ruben SM, Dillon PJ, Schreck R, Henkel T, Chen CH, Maher M, Baeuerle PA, Rosen CA
Title
Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.
Journal
Science 251:1490-3 (1991)
DOI:
10.1126/science.2006423
Sequence
[hsa:
5970
]
LinkDB
All DBs
DBGET
integrated database retrieval system
