KEGG ORTHOLOGY: K04850

ORTHOLOGY: K04850

Entry

K04850                      KO

Symbol

CACNA1C, CAV1.2

Name

voltage-dependent calcium channel L type alpha-1C

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04270

Vascular smooth muscle contraction

map04713

Circadian entrainment

map04720

Long-term potentiation

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04742

Taste transduction

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04921

Oxytocin signaling pathway

map04924

Renin secretion

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04929

GnRH secretion

map04930

Type II diabetes mellitus

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05031

Amphetamine addiction

map05207

Chemical carcinogenesis - receptor activation

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00720

Long QT syndrome

H00728

Brugada syndrome

H02397

Neurodevelopmental disorder with movement abnormalities or hypotonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04020 Calcium signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04024 cAMP signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04022 cGMP-PKG signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04929 GnRH secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04912 GnRH signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04921 Oxytocin signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04935 Growth hormone synthesis, secretion and action
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04924 Renin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04925 Aldosterone synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04927 Cortisol synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04261 Adrenergic signaling in cardiomyocytes
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04270 Vascular smooth muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09156 Nervous system
   04724 Glutamatergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04727 GABAergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04725 Cholinergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04728 Dopaminergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04726 Serotonergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04720 Long-term potentiation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04723 Retrograde endocannabinoid signaling
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09157 Sensory system
   04742 Taste transduction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05020 Prion disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05022 Pathways of neurodegeneration - multiple diseases
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09165 Substance dependence
   05031 Amphetamine addiction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05414 Dilated cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04934 Cushing syndrome
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C

Other DBs

GO:

0005245

TC:	1.A.1.11.4 1.A.1.11.6

Genes

HSA:	775(CACNA1C)

PTR:	466915(CACNA1C)

PPS:	100971701(CACNA1C)

GGO:	101134060(CACNA1C)

PON:	100442085(CACNA1C)

PPYG:

129009980

NLE:	100580437(CACNA1C)

HMH:	116472525(CACNA1C)

SSYN:

129483539

MCC:	721721(CACNA1C)

MCF:	101865175(CACNA1C)

MTHB:

126930225

MNI:	105484109(CACNA1C)

CSAB:

103218385(CACNA1C)

CATY:

105582968(CACNA1C)

PANU:

101026237(CACNA1C)

TGE:	112634000(CACNA1C)

MLEU:

105529889(CACNA1C)

RRO:	104659017(CACNA1C)

RBB:	108522695(CACNA1C)

TFN:

117090701

PTEH:

111520328(CACNA1C)

CANG:

105503912(CACNA1C)

CJC:	100406735(CACNA1C)

SBQ:	101040048(CACNA1C)

CIMI:

108315880(CACNA1C)

ANAN:

105733730(CACNA1C)

CSYR:

103259018(CACNA1C)

MMUR:

105861596(CACNA1C)

LCAT:

123640189(CACNA1C)

PCOQ:

105815791(CACNA1C)

OGA:	100964267(CACNA1C)

MMU:	12288(Cacna1c)

MCAL:

110295755

MPAH:

110317086(Cacna1c)

RNO:	24239(Cacna1c)

MCOC:

116099482(Cacna1c)

ANU:	117715086(Cacna1c)

MUN:	110541273(Cacna1c)

CGE:	100754788(Cacna1c)

MAUA:

101834428(Cacna1c)

PROB:

127236163(Cacna1c)

PLEU:

114700762(Cacna1c)

MORG:

121441414(Cacna1c)

MFOT:

126505446

AAMP:

119806908(Cacna1c)

NGI:	103739378(Cacna1c)

HGL:	101717129(Cacna1c)

CPOC:

100135490(Cacna1c)

DORD:

105991064(Cacna1c)

PLOP:

125342716(Cacna1c)

NCAR:

124982084

MMMA:

107154890(Cacna1c)

OCU:	100101555(CACNA1C)

OPI:	101536063(CACNA1C)

GVR:	103595029(CACNA1C)

CFA:	403516(CACNA1C)

CLUD:

112668971(CACNA1C)

VVP:	112917426(CACNA1C)

VLG:	121479835(CACNA1C)

NPO:	129503382(CACNA1C)

AML:	100479715(CACNA1C)

UMR:	103675706(CACNA1C)

UAH:	113258052(CACNA1C)

UAR:	123777895(CACNA1C)

ELK:

111159674

LLV:

125107204

MPUF:

101679746(CACNA1C)

MNP:	132019988(CACNA1C)

MLK:	131838359(CACNA1C)

NVS:	122892214(CACNA1C)

ORO:	101365624(CACNA1C)

EJU:	114222521(CACNA1C)

ZCA:	113921757(CACNA1C)

MLX:	118025809(CACNA1C)

NSU:	110581023(CACNA1C)

FCA:	101082923(CACNA1C)

PYU:	121022112(CACNA1C)

PCOO:

112867221(CACNA1C)

PBG:	122473119(CACNA1C)

PVIV:

125170417(CACNA1C)

LRUF:

124501399

PTG:	102956322(CACNA1C)

PPAD:

109276255(CACNA1C)

PUC:

125920056

AJU:

106965473

HHV:	120243774(CACNA1C)

BTA:	408015(CACNA1C)

BOM:	102277590(CACNA1C)

BIU:	109558615(CACNA1C)

BBUB:

102407190(CACNA1C)

BBIS:

104992358(CACNA1C)

CHX:	100861292(CACNA1C)

OAS:	101116562(CACNA1C)

BTAX:

128048945(CACNA1C)

ODA:	120857839(CACNA1C)

CCAD:

122424089(CACNA1C)

MBEZ:

129535727(CACNA1C)

SSC:	100518733(CACNA1C)

CFR:	102524149(CACNA1C)

CBAI:

105076642(CACNA1C)

CDK:	105100748(CACNA1C)

VPC:	102538871(CACNA1C)

BACU:

103019389(CACNA1C)

BMUS:

118901684(CACNA1C)

LVE:	103087340(CACNA1C)

OOR:	101272740(CACNA1C)

DLE:	111176594(CACNA1C)

PCAD:

102989784(CACNA1C)

PSIU:

116760103(CACNA1C)

NASI:

112391637(CACNA1C)

ECB:	100049924(CACNA1C)

EAI:	106839455(CACNA1C)

MYB:	102240225(CACNA1C)

MYD:	102753812(CACNA1C)

MMYO:

118652154(CACNA1C)

MLF:	102424719(CACNA1C)

MDT:	132228098(CACNA1C)

PKL:	118730029(CACNA1C)

EFUS:

103296724(CACNA1C)

MNA:	107546425(CACNA1C)

DRO:	112309331(CACNA1C)

SHON:

118999983(CACNA1C)

AJM:	119051688(CACNA1C)

PDIC:

114512949(CACNA1C)

PHAS:

123813423(CACNA1C)

MMF:	118624255(CACNA1C)

PPAM:

129073529(CACNA1C)

HAI:	109388950(CACNA1C)

RFQ:	117029264(CACNA1C)

PALE:

102882682(CACNA1C)

PGIG:

120607351(CACNA1C)

PVP:	105297298(CACNA1C)

RAY:	107500540(CACNA1C)

MJV:	108387253(CACNA1C)

TOD:	119247058(CACNA1C)

SARA:

101557862(CACNA1C)

SETR:

126022196(CACNA1C)

TMU:

101360945

ETF:	101656925(CACNA1C)

DNM:	101431301(CACNA1C)

MDO:	100021421(CACNA1C)

GAS:	123250056(CACNA1C)

SHR:

100926503

AFZ:

127564847

PCW:	110218748(CACNA1C)

TVP:	118849734(CACNA1C)

OAA:	100082618(CACNA1C)

GGA:	395891(CACNA1C)

PCOC:

116226870(CACNA1C)

MGP:	100547459 104911865

CJO:	107315213(CACNA1C)

TPAI:

128073122(CACNA1C)

LMUT:

125693421(CACNA1C)

NMEL:

110395457(CACNA1C)

APLA:

101790062(CACNA1C)

ACYG:

106030933(CACNA1C)

CATA:

118250054(CACNA1C)

AFUL:

116489537(CACNA1C)

TGU:	100218244(CACNA1C)

LSR:	110472925(CACNA1C)

SCAN:

103820462(CACNA1C)

PMOA:

120501729(CACNA1C)

OTC:	121332892(CACNA1C)

PRUF:

121362733(CACNA1C)

GFR:

102031898

FAB:	101815051(CACNA1C)

OMA:	130263585(CACNA1C)

PHI:	102106069(CACNA1C)

PMAJ:

107204397(CACNA1C)

CCAE:

111928486

CCW:	104692245(CACNA1C)

CBRC:

103624725(CACNA1C)

ETL:	114069083(CACNA1C)

ZAB:	102070167(CACNA1C)

ZLE:	135459658(CACNA1C)

ACHL:

103806638(CACNA1C)

SVG:	106849354(CACNA1C)

MMEA:

130588985(CACNA1C)

HRT:	120751816(CACNA1C)

SATI:

136361465(CACNA1C)

FPG:	101916694(CACNA1C)

FCH:	102048150(CACNA1C)

NNT:

104410749

SHAB:

115605742(CACNA1C)

ACUN:

113475961(CACNA1C)

TALA:

104361153(CACNA1C)

ACHC:

115352314(CACNA1C)

HALD:

104325178

HLE:	104830930(CACNA1C)

AGEN:

126047933

GCL:

127013811

CSTI:

104563363

LDI:	104353406(CACNA1C)

MNB:	103768936(CACNA1C)

DPUB:

104299582(CACNA1C)

AVIT:

104278438(CACNA1C)

EGZ:	104134399(CACNA1C)

NNI:	104020209(CACNA1C)

PADL:

103924366(CACNA1C)

AFOR:

103898648(CACNA1C)

FGA:

104072796

CLV:	102095010(CACNA1C)

MUI:

PGUU:

PLET:

EHS:

CMAC:

104487032(CACNA1C)

CUCA:

104055901(CACNA1C)

OHA:	104330270(CACNA1C)

CPEA:

104386585(CACNA1C)

CVF:	104281606(CACNA1C)

RTD:	128909658(CACNA1C)

AAM:	106488364(CACNA1C)

AROW:

112968301(CACNA1C)

DNE:	112993380(CACNA1C)

SCAM:

104147270(CACNA1C)

ASN:	102377475(CACNA1C)

AMJ:	102575519(CACNA1C)

CPOO:

109316457(CACNA1C)

GGN:	109296233(CACNA1C)

PSS:	102451554(CACNA1C)

CMY:	102940198(CACNA1C)

CCAY:

125625969(CACNA1C)

DCC:	119848353(CACNA1C)

CPIC:

101946823(CACNA1C)

TST:	117882551(CACNA1C)

CABI:

116834346

MRV:	120408934(CACNA1C)

ACS:	100553244(cacna1c)

ASAO:

132775772(CACNA1C)

PVT:	110076659(CACNA1C)

SUND:

121932087(CACNA1C)

PMUR:

107288329(CACNA1C)

CTIG:

120315478(CACNA1C)

PGUT:

117655788(CACNA1C)

APRI:

131202696(CACNA1C)

PTEX:

113447447(CACNA1C)

NSS:	113419359(CACNA1C)

VKO:	123016508(CACNA1C)

PMUA:

114605885

PRAF:

128422166(CACNA1C)

ZVI:	118090932(CACNA1C)

HCG:	128326984(CACNA1C)

GJA:	107120231(CACNA1C)

STOW:

125434341(CACNA1C)

EMC:	129335461(CACNA1C)

XLA:	100462911(cacna1c.S) 108704565(cacna1c.L)

XTR:	100488055(cacna1c)

NPR:

108791575

RTEM:

120932711(CACNA1C)

BBUF:

121004433(CACNA1C)

BGAR:

122928487(CACNA1C)

MUO:	115477346(CACNA1C)

GSH:	117363429(CACNA1C)

DRE:	170581(cacna1c)

SRX:

107732972

SANH:

107694143

SGH:	107589041 107590584

CCAR:

109104295

CAUA:

113048094 113062313

CGIB:

127956189 127973732

PTET:

122342654(cacna1c)

LROH:

127164112(cacna1c)

OMC:	131538945(cacna1c)

PPRM:

120476944(cacna1c)

RKG:	130072307(cacna1c)

MAMB:

125245652(cacna1c)

CIDE:

127511476

CERY:

137024507(cacna1c)

MASI:

127435437 127436755

TROS:

130547673(cacna1c)

TDW:	130420342(cacna1c)

MANU:

129431773(cacna1c)

IPU:	108279829(cacna1c)

IFU:	128622995(cacna1c)

PHYP:

113544629

SMEO:

124401221(cacna1c)

TFD:	113663733(cacna1c)

TVC:	132858817(cacna1c)

TRN:	134312571(cacna1c)

AMEX:

103041474(cacna1c)

CMAO:

118812645(cacna1c)

EEE:

113576556

CHAR:

105911367(cacna1c)

TRU:	101064574(cacna1c)

TFS:	130519478(cacna1c)

LCO:

104940547

TBEN:

117484877(cacna1c)

CGOB:

115028206(cacna1c)

PGEO:

117468450(cacna1c)

GACU:

117536109(cacna1c)

EMAC:

134879379(cacna1c)

ELY:	117249155(cacna1c)

EFO:	125883250(cacna1c)

PLEP:

121961140

SLUC:

116059999(cacna1c)

ECRA:

117938808(cacna1c)

ESP:

116672836

PFLV:

114549894

GAT:	120818340(cacna1c)

PPUG:

119210128(cacna1c)

AFB:	129112503(cacna1c)

CLUM:

117726173(cacna1c)

PSWI:

130200799(cacna1c)

MSAM:

119918210(cacna1c)

SCHU:

122871614(cacna1c)

CUD:	121505730(cacna1c)

ALAT:

119032303(cacna1c)

ASTR:

137589140(cacna1c)

MZE:	101471946(cacna1c)

ONL:	100711294(cacna1c)

OAU:	116309817(cacna1c)

OLA:

101173517

OML:	112156742(cacna1c)

CSAI:

133424498(cacna1c)

XMA:	102230290(cacna1c)

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122826690(cacna1c)

PPRL:

129375629(cacna1c)

CVG:

107095494

CTUL:

119786207(cacna1c)

GMU:	124882886(cacna1c)

NFU:	107385235(cacna1c)

KMR:	108235074(cacna1c)

ALIM:

106515158

NWH:	119428184(cacna1c)

AOCE:

111571438

MCEP:

124999862(cacna1c)

CSEM:

103382787(cacna1c)

POV:

109632862

SSEN:

122767001(cacna1c)

HHIP:

117757229(cacna1c)

HSP:	118101730(cacna1c)

PPLT:

128428423(cacna1c)

SMAU:

118292530(cacna1c)

LCF:	108879625(cacna1c)

SDU:	111224579(cacna1c)

SLAL:

111658797(cacna1c)

XGL:	120800940(cacna1c)

HCQ:

109520063

SSCV:

125992468

SBIA:

133493429(cacna1c)

PEE:	133397145(cacna1c)

PTAO:

133471941(cacna1c)

BPEC:

110162494

MALB:

109959866

BSPL:

114862070(cacna1c)

SJO:	128353427(cacna1c)

OTW:

112240960

OMY:	110518351 110518394

OGO:	123995860 124020959 124024504

OKI:

109882530

OKE:	127925063(cacna1c)

SNH:	120032122(cacna1c)

CCLU:

121553635(cacna1c)

ELS:	105023097(cacna1c)

SFM:	108920904(cacna1c)

PKI:	111843125(cacna1c)

AANG:

118231977(cacna1c)

LOC:	102684408(cacna1c)

PSPA:

121318589 121319532

ARUT:

117415426 117419745

PSEX:

120540046

LCM:	102357941(CACNA1C)

CMK:	103179419(cacna1c)

RTP:

109920177

CPLA:

122559424(cacna1c)

HOC:	132824959(cacna1c)

LERI:

129706126(cacna1c)

PMRN:

116942266

LRJ:	133349342 133356809

SCLV:

TPAL:

MRJ:

LPOL:

PMEO:

PVUL:

BGT:

CRG:

CANU:

CVN:

MCAF:

MMER:

DPOL:

XEN:

HSY:

Reference

PMID:17071743

Authors

Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM

Title

Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.

Journal

Proc Natl Acad Sci U S A 103:17024-9 (2006)
DOI:10.1073/pnas.0606539103

Sequence

[hsa:775]

Reference

PMID:1316612

Authors

Soldatov NM

Title

Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.

Journal

Proc Natl Acad Sci U S A 89:4628-32 (1992)
DOI:10.1073/pnas.89.10.4628

Sequence

[hsa:775]

LinkDB

ORTHOLOGY: K04851

Entry

K04851                      KO

Symbol

CACNA1D, CAV1.3

Name

voltage-dependent calcium channel L type alpha-1D

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04218

Cellular senescence

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04270

Vascular smooth muscle contraction

map04361

Axon regeneration

map04530

Tight junction

map04713

Circadian entrainment

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04921

Oxytocin signaling pathway

map04924

Renin secretion

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04929

GnRH secretion

map04930

Type II diabetes mellitus

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map04973

Carbohydrate digestion and absorption

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05031

Amphetamine addiction

map05207

Chemical carcinogenesis - receptor activation

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H01603

Primary aldosteronism

H02636

Sinoatrial node dysfunction and deafness

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04020 Calcium signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04024 cAMP signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04022 cGMP-PKG signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04929 GnRH secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04912 GnRH signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04921 Oxytocin signaling pathway
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04935 Growth hormone synthesis, secretion and action
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04924 Renin secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04925 Aldosterone synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04927 Cortisol synthesis and secretion
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04261 Adrenergic signaling in cardiomyocytes
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04270 Vascular smooth muscle contraction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09156 Nervous system
   04724 Glutamatergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04727 GABAergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04725 Cholinergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04728 Dopaminergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04726 Serotonergic synapse
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04723 Retrograde endocannabinoid signaling
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09158 Development and regeneration
   04361 Axon regeneration
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05020 Prion disease
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05022 Pathways of neurodegeneration - multiple diseases
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09165 Substance dependence
   05031 Amphetamine addiction
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   05414 Dilated cardiomyopathy
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
   04934 Cushing syndrome
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D

Other DBs

GO:

0005245

TC:	1.A.1.11.1 1.A.1.11.20 1.A.1.11.21

Genes

HSA:	776(CACNA1D)

PTR:	460447(CACNA1D)

PPS:	100975108(CACNA1D)

GGO:	101140987(CACNA1D)

PON:	100453904(CACNA1D)

PPYG:

129034246(CACNA1D)

NLE:	100600997(CACNA1D)

HMH:	116473372(CACNA1D)

SSYN:

129479899(CACNA1D)

MCC:	693924(CACNA1D)

MCF:	102138213(CACNA1D)

MTHB:

126948779

MNI:	105480573(CACNA1D)

CSAB:

103227762(CACNA1D)

CATY:

105585586(CACNA1D)

PANU:

101002070(CACNA1D)

TGE:	112618467(CACNA1D)

MLEU:

105543978(CACNA1D)

RRO:	104672388(CACNA1D)

RBB:	108515198(CACNA1D)

TFN:	117083004(CACNA1D)

PTEH:

111524370(CACNA1D)

CANG:

105515441(CACNA1D)

CJC:	100397940(CACNA1D)

SBQ:	101043152(CACNA1D)

CIMI:

108281194(CACNA1D)

ANAN:

105722924(CACNA1D)

CSYR:

103257199(CACNA1D)

MMUR:

105875072(CACNA1D)

LCAT:

123623167(CACNA1D)

PCOQ:

105805290(CACNA1D)

OGA:	100953767(CACNA1D)

MMU:	12289(Cacna1d)

MCAL:

110309492(Cacna1d)

MPAH:

110325961(Cacna1d)

RNO:	29716(Cacna1d)

MCOC:

116084337(Cacna1d)

ANU:	117705045(Cacna1d)

MUN:	110547567(Cacna1d)

CGE:	100772497(Cacna1d)

MAUA:

101825756(Cacna1d)

PROB:

127236838(Cacna1d)

PLEU:

114686204(Cacna1d)

MORG:

121454953(Cacna1d)

MFOT:

126511130

AAMP:

119828004(Cacna1d)

NGI:	103749025(Cacna1d)

HGL:	101714832(Cacna1d)

CPOC:

100726255(Cacna1d)

CCAN:

109674812(Cacna1d)

DORD:

105996591(Cacna1d)

DSP:	122108123(Cacna1d)

PLOP:

125358578(Cacna1d)

NCAR:

124968359

MMMA:

107149619(Cacna1d)

OCU:	100327259(CACNA1D)

OPI:	101524545(CACNA1D)

TUP:	102484770(CACNA1D)

GVR:

103603077

CFA:	484724(CACNA1D)

CLUD:

112665919(CACNA1D)

VVP:	112910069(CACNA1D)

VLG:	121494863(CACNA1D)

NPO:	129521343(CACNA1D)

AML:	100467700(CACNA1D)

UMR:	103674739(CACNA1D)

UAH:	113256986(CACNA1D)

UAR:	123798762(CACNA1D)

ELK:

111143738

LLV:

125078710

MPUF:

101669870(CACNA1D)

MNP:	132011423(CACNA1D)

MLK:	131824037(CACNA1D)

NVS:	122909338(CACNA1D)

ORO:	101383514(CACNA1D)

EJU:	114225091(CACNA1D)

ZCA:	113916795(CACNA1D)

MLX:	118006050(CACNA1D)

NSU:	110584803(CACNA1D)

LWW:	102731073(CACNA1D)

FCA:	101088394(CACNA1D)

PYU:	121016834(CACNA1D)

PCOO:

112852481(CACNA1D)

PBG:	122487331(CACNA1D)

PVIV:

125160941(CACNA1D)

LRUF:

124522821

PTG:	102958456(CACNA1D)

PPAD:

109247930(CACNA1D)

AJU:

106986998

HHV:	120239388(CACNA1D)

BTA:	408013(CACNA1D)

BOM:	102271623(CACNA1D)

BIU:	109576190(CACNA1D)

BBUB:

102405249(CACNA1D)

BBIS:

104997112(CACNA1D)

CHX:	102174706(CACNA1D)

OAS:	101106371(CACNA1D)

BTAX:

128052044(CACNA1D)

ODA:	120868392(CACNA1D)

CCAD:

122424654(CACNA1D)

MBEZ:

129547932(CACNA1D)

SSC:	100511102(CACNA1D)

CFR:	102504854(CACNA1D)

CBAI:

105079596(CACNA1D)

CDK:	105093176(CACNA1D)

VPC:	102539274(CACNA1D)

BACU:

103001906(CACNA1D)

BMUS:

118903384(CACNA1D)

LVE:	103074544(CACNA1D)

OOR:	101276749(CACNA1D)

DLE:	111174277(CACNA1D)

PCAD:

102976068(CACNA1D)

PSIU:

116762723(CACNA1D)

NASI:

112400535(CACNA1D)

ECB:	100051186(CACNA1D)

EPZ:

103560754

EAI:	106822066(CACNA1D)

MYB:	102259218(CACNA1D)

MYD:	102761441(CACNA1D)

MMYO:

118667975(CACNA1D)

MLF:	102420982(CACNA1D)

MDT:	132215285(CACNA1D)

PKL:	118715119(CACNA1D)

EFUS:

103290420(CACNA1D)

MNA:	107534931(CACNA1D)

DRO:	112301160(CACNA1D)

SHON:

118983345(CACNA1D)

AJM:	119041393(CACNA1D)

PDIC:

114501473(CACNA1D)

PHAS:

123814577(CACNA1D)

MMF:	118632910(CACNA1D)

PPAM:

129088299(CACNA1D)

HAI:	109395944(CACNA1D)

RFQ:	117036785(CACNA1D)

PALE:

102888351(CACNA1D)

PGIG:

120606299(CACNA1D)

PVP:	105304363(CACNA1D)

RAY:	107516535(CACNA1D)

MJV:	108402355(CACNA1D)

TOD:	119237589(CACNA1D)

SARA:

101546311(CACNA1D)

SETR:

126013230(CACNA1D)

LAV:	100659992(CACNA1D)

TMU:

101357085

ETF:	101651425(CACNA1D)

DNM:

101418484

MDO:	100014450(CACNA1D)

GAS:	123246606(CACNA1D)

SHR:	100919750(CACNA1D)

AFZ:

127550201

PCW:	110197022(CACNA1D)

TVP:	118830781(CACNA1D)

OAA:	100077296(CACNA1D)

GGA:	395895(CACNA1D)

PCOC:

116238597(CACNA1D)

MGP:	100545748(CACNA1D)

CJO:	107319871(CACNA1D)

TPAI:

128078544(CACNA1D)

LMUT:

125698969(CACNA1D)

NMEL:

110404743(CACNA1D)

APLA:

101803307(CACNA1D)

ACYG:

106048937(CACNA1D)

CATA:

118253668(CACNA1D)

AFUL:

116493152(CACNA1D)

TGU:	100226925(CACNA1D)

LSR:	110471933(CACNA1D)

SCAN:

103816992(CACNA1D)

PMOA:

120514084(CACNA1D)

OTC:	121347178(CACNA1D)

PRUF:

121350165(CACNA1D)

GFR:	102035179(CACNA1D)

FAB:	101819434(CACNA1D)

OMA:	130258122(CACNA1D)

PHI:	102103301(CACNA1D)

PMAJ:

107210294(CACNA1D)

CCAE:

111935128(CACNA1D)

CCW:	104683258(CACNA1D)

CBRC:

103614395(CACNA1D)

ETL:	114058704(CACNA1D)

ZAB:	102066654(CACNA1D)

ZLE:	135453330(CACNA1D)

ACHL:

103802711(CACNA1D)

SVG:	106849165(CACNA1D)

HRT:	120758054(CACNA1D)

SATI:

136365985(CACNA1D)

FPG:	101912795(CACNA1D)

FCH:	102054190(CACNA1D)

CCRI:

104161553(CACNA1D)

NNT:	104405060(CACNA1D)

SHAB:

115614870(CACNA1D)

ACUN:

113484825(CACNA1D)

TALA:

104357870(CACNA1D)

ACHC:

115353734(CACNA1D)

HLE:	104834968(CACNA1D)

AGEN:

126049719

GCL:

127021725

CSTI:

104561672(CACNA1D)

LDI:	104342482(CACNA1D)

MNB:	103780751(CACNA1D)

DPUB:

104300406(CACNA1D)

AVIT:

104270141(CACNA1D)

BRHI:

104496602

EGZ:	104126731(CACNA1D)

NNI:	104009116 104010825(CACNA1D)

PCAO:

104047042(CACNA1D)

PADL:

103925489(CACNA1D)

AFOR:

103903298(CACNA1D)

FGA:

104074873

GSTE:

104264662(CACNA1D)

CLV:	102091108(CACNA1D)

PGUU:

104469831(CACNA1D)

PLET:

104621806(CACNA1D)

EHS:	104514234(CACNA1D)

CMAC:

104482547(CACNA1D)

CUCA:

104066716(CACNA1D)

TEO:	104379566(CACNA1D)

BREG:

104634218

OHA:	104338432(CACNA1D)

ACAR:

104521460(CACNA1D)

CPEA:

104384912(CACNA1D)

CVF:	104282808(CACNA1D)

RTD:	128915456(CACNA1D)

AAM:	106488627(CACNA1D)

AROW:

112971310(CACNA1D)

NPD:	112953071(CACNA1D)

TGT:

104571863

DNE:	112984734(CACNA1D)

SCAM:

104152762(CACNA1D)

ASN:	102373960(CACNA1D)

AMJ:	102576817(CACNA1D)

CPOO:

109311400(CACNA1D)

GGN:	109288857(CACNA1D)

PSS:	102447276(CACNA1D)

CMY:	102934282(CACNA1D)

CCAY:

125639955(CACNA1D)

DCC:	119858685(CACNA1D)

CPIC:

101951786(CACNA1D)

TST:	117880097(CACNA1D)

CABI:

116838746

MRV:	120409125(CACNA1D)

ACS:	100554865(cacna1d)

ASAO:

132769269(CACNA1D)

PVT:	110084495(CACNA1D)

SUND:

121921137(CACNA1D)

PBI:	103056075(CACNA1D)

PMUR:

107287678(CACNA1D)

CTIG:

120315892(CACNA1D)

TSR:	106544410 106555246

PGUT:

117677102(CACNA1D)

APRI:

131192185(CACNA1D)

PTEX:

113449745(CACNA1D)

NSS:	113417804(CACNA1D)

VKO:	123034083(CACNA1D)

PMUA:

114591684(CACNA1D)

PRAF:

128408307(CACNA1D)

ZVI:	118080704(CACNA1D)

HCG:	128342176(CACNA1D)

GJA:	107116832(CACNA1D)

STOW:

125429860(CACNA1D)

EMC:	129326985(CACNA1D)

XLA:	100462912(cacna1d.L) 108704388

NPR:	108786047(CACNA1D)

RTEM:

120945252(CACNA1D)

BBUF:

120979492(CACNA1D)

BGAR:

122943424(CACNA1D)

MUO:	115471691(CACNA1D)

GSH:	117351101(CACNA1D)

DRE:	403310(cacna1da) 403311(cacna1db)

SRX:	107711792 107730640 107743249 107751208

SANH:

107659558 107669025 107684460 107685994

SGH:	107549565 107581799 107582429 107594982

CCAR:

109094680 109098788

CAUA:

113055476 113107872 113110814

CGIB:

127963129 127968377 128022121

PTET:

122335503 122353965(cacna1da)

LROH:

127170043(cacna1db) 127172762(cacna1da)

OMC:	131546233(cacna1db) 131549742(cacna1da)

PPRM:

120480507(cacna1da) 120481259(cacna1db)

RKG:	130082146(cacna1db) 130083495(cacna1da)

MAMB:

125256332(cacna1da) 125280569(cacna1db)

CIDE:

127516967 127522496

CERY:

137021437(cacna1da) 137026710(cacna1db)

MASI:

127424719 127426069 127427713

TROS:

130568353(cacna1db) 130571700(cacna1da)

TDW:	130410399(cacna1da) 130439975(cacna1db)

MANU:

129413527(cacna1db) 129427181(cacna1da)

IPU:	108265454(cacna1db) 108281043(cacna1da)

IFU:	128607646(cacna1db) 128625366(cacna1da)

PHYP:

113533266(cacna1d) 113539515

SMEO:

124400064(cacna1db) 124402332(cacna1da)

TFD:	113637037(cacna1da) 113655977(cacna1db)

TVC:	132837870(cacna1da) 132853210(cacna1db)

TRN:	134301570(cacna1da) 134318336(cacna1db)

AMEX:

103033357(cacna1db) 103043956(cacna1da)

CMAO:

118799526 118813381(cacna1db)

EEE:	113579158 113580442(cacna1d)

CHAR:

105898925 105903391(cacna1da)

TRU:	101066777(cacna1d) 101070235

TFS:	130524113(cacna1da) 130530552(cacna1db)

TNG:	GSTEN00022583G001 GSTEN00027380G001

LCO:	104925122 104926938

NCC:	104942817 104946163(cacna1d)

TBEN:

117489733 117494031(cacna1db)

CGOB:

115008852(cacna1d)

PGEO:

117446450(cacna1da) 117449341(cacna1db)

GACU:

117541859(cacna1db) 117548197(cacna1da)

EMAC:

134865717(cacna1db) 134882741(cacna1da)

ELY:	117257145(cacna1da) 117258176(cacna1db)

EFO:	125886476(cacna1da) 125891151(cacna1db)

PLEP:

121946664(cacna1db) 121959083(cacna1da)

SLUC:

116040630(cacna1db) 116041539(cacna1da)

ECRA:

117942646(cacna1da) 117947687(cacna1db)

ESP:	116687621 116692928

PFLV:

114553636 114558551(cacna1d)

GAT:	120829866(cacna1db) 120835798(cacna1da)

PPUG:

119222219(cacna1db) 119229415(cacna1da)

AFB:	129099230(cacna1db) 129106296(cacna1da)

CLUM:

117730481 117733217(cacna1db)

PSWI:

130200179(cacna1db) 130208331(cacna1da)

MSAM:

119886716(cacna1da) 119905703(cacna1db)

SCHU:

122863128(cacna1da) 122882704(cacna1db)

CUD:	121506740(cacna1da) 121517267

ALAT:

119021040(cacna1da) 119023270(cacna1db)

ASTR:

137594852(cacna1da) 137608200(cacna1db)

MZE:	101474865(cacna1d) 101485620

ONL:	100693494 100712099(cacna1d)

OAU:	116324683(cacna1db) 116328943(cacna1da)

OLA:	101157531 101171831(cacna1d)

OML:	112144629(cacna1da) 112159387(cacna1db)

CSAI:

133448540(cacna1da) 133457377(cacna1db)

XMA:	102234425(cacna1d) 102234457

XCO:	114135515 114148180(cacna1d)

XHE:	116710265 116725097(cacna1d)

PRET:

103465120 103468016(cacna1d)

PFOR:

103138155 103156027

PLAI:

106945205 106952887

PMEI:

106918048 106919948(cacna1d)

GAF:	122833388(cacna1da) 122840116(cacna1db)

PPRL:

129352870(cacna1da) 129356852 129372579

CVG:	107086672(cacna1d) 107094760

CTUL:

119780005 119789213(cacna1db)

GMU:	124856470(cacna1da) 124869361(cacna1db)

NFU:	107385116 107390617(cacna1d)

KMR:	108236775(cacna1db) 108247381(cacna1da)

ALIM:

106513069(cacna1d) 106516186

NWH:	119411902(cacna1da) 119417689(cacna1db)

AOCE:

111571955 111584413

MCEP:

124998958(cacna1db) 125006589(cacna1da)

CSEM:

103384525 103385821

POV:	109630732 109638586

SSEN:

122767592(cacna1da) 122777142

HHIP:

117761329(cacna1da) 117765094(cacna1db)

HSP:	118105190(cacna1da) 118111329(cacna1db)

PPLT:

128441761(cacna1db) 128451357(cacna1da)

SMAU:

118309449(cacna1da) 118316309(cacna1db)

LCF:	108886531(cacna1da) 108891636(cacna1db)

SDU:	111220529 111222823

SLAL:

111660720 111670707

XGL:	120803559(cacna1db) 120807074(cacna1da)

HCQ:	109517788(cacna1d) 109522320

SSCV:

125977228 125987755

SBIA:

133507027(cacna1da)

PEE:	133399393(cacna1db) 133408965(cacna1da)

PTAO:

133474397(cacna1db) 133483429(cacna1da)

BPEC:

110168588 110174734(cacna1d)

MALB:

109951925 109970859(cacna1d)

BSPL:

114855133(cacna1da) 114859479(cacna1db)

SJO:	128355865(cacna1da) 128357906(cacna1db)

SASA:

106565299 106566685 106571974 106583449

STRU:

115166217 115168317 115208210

OTW:	112215828 112222121 112244799 112255325

OMY:	100135991(cacna1da) 110493200(cacna1da) 110531171

OGO:	124003209 124028199 124045737

ONE:	115124333 115131694 115131954 115142708

OKI:	109869746 109891346 109892681 109907825

OKE:	118361111 118372828 118377279

SALP:

111962116 111966893 111970724 111976881(cacna1d)

SNH:	120059461 120061615 120063162 120065363

CCLU:

121538133 121545480 121575421 121578114

ELS:	105006991 105007355(cacna1d)

SFM:	108925619(cacna1d) 108933838

PKI:	111833375(cacna1d) 111852542

AANG:

118208113 118211309

LOC:	102695139(cacna1d)

PSPA:

121298208 121328825

ARUT:

117412172 117413950

LCM:	102360815(CACNA1D)

CMK:

103185068

RTP:	109930589(cacna1da)

CPLA:

HOC:

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SPU:	115917871 578128

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG4894(Ca-alpha1D)

DER:

6543266

DSE:

6613668

DSI:	Dsimw501_GD24041(Dsim_GD24041)

DYA:	Dyak_GE21343

DSR:

DPE:

DMN:

DGR:

DAZ:

DNV:

DHE:

BOD:

BDR:

RZE:	108371229 108371590

AOQ:

TDA:

SCAC:

LCQ:

GFS:	119634168 119638475

ECOE:

129953325

CLON:

129613774

HIS:

119660711

AGA:	3292158 4578503

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

BCOO:

LLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

DCOR:

135797527(Ca-alpha1D)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203769 KGM_214501 KGM_214502

BANY:

112055019 112056463

MJU:	123877191 123877423

NIQ:	126777964 126777965

VCD:	124540440 124540498

MCIX:

123666462 123666569

PMAC:

106707301 106711272

PPOT:

106111420 106111443

PXU:	106123145 106123148

PRAP:

110993876 111001158

PBX:	123714835 123714954

PNAP:

125057007 125057063

ZCE:	119837620 119837677

CCRC:

123703407 123703580

LSIN:

126970124

AAGE:

121736468 121736876

HAW:	110372633 110372635

HZE:	124642743 124642773

TNL:	113497967 113498006

SLIU:

111362213 111363413

OFU:	114362210 114365957

ATRA:

106136507 106136527

GMW:	113521049 113521059

PXY:	105386242 105387767

PGW:	126377799 126377800

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106680454(Ca-alpha1D)

NLU:	111044977 111052182

HVI:	124356847 124369221

MQU:	129005578 129005959

PHU:	Phum_PHUM510590

FOC:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110849059 110850936

DPX:	DAPPUDRAFT_310458

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111701830 111703149 111706123 111710410 111714152

LSM:	121122350 121127432

TCF:

PPOI:

DSV:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136972132 136974893

PTEP:

107444401 107449579

ABRU:

129956888 129964288

UDV:	129217393 129222623

SDM:

118200226

LPOL:

106464499 106470133

PMEO:

129591676

CEL:	CELE_C48A7.1(egl-19)

CBR:	CBG_05858(Cbr-egl-19)

BMY:	BM_BM2825(Bma-egl-19)

LOA:	LOAG_17197

TSP:	Tsp_06861 Tsp_07724

HRO:	HELRODRAFT_128998

LGI:	LOTGIDRAFT_51275

PCAN:

GAE:

HRF:

HRJ:

OED:

MYI:

PMAX:

RPHI:

OBI:

OSN:

LAK:

SMM:	Smp_020270 Smp_159990

SHX:	MS3_00004799(CACNA1C_1) MS3_00006217(CACNA1C_2)

OVI:	T265_01818 T265_01820 T265_15629

EGL:	EGR_02129 EGR_08501

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

CRE:	CHLRE_17g720600v5

OLU:	OSTLU_13647 OSTLU_32140

OTA:	OT_ostta06g02060

SRE:	PTSG_09464

PTM:	GSPATT00017333001

AAF:	AURANDRAFT_67051

PIF:	PITG_03693 PITG_08764

SPAR:

SPRG_10678 SPRG_10680

» show all

Reference

PMID:21131953

Authors

Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nurnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nurnberg P, Striessnig J, Bolz HJ

Title

Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.

Journal

Nat Neurosci 14:77-84 (2011)
DOI:10.1038/nn.2694

Reference

PMID:1309948

Authors

Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI

Title

Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.

Journal

Proc Natl Acad Sci U S A 89:584-8 (1992)
DOI:10.1073/pnas.89.2.584

Sequence

[hsa:776]

LinkDB

ORTHOLOGY: K04853

Entry

K04853                      KO

Symbol

CACNA1F, CAV1.4

Name

voltage-dependent calcium channel L type alpha-1F

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04270

Vascular smooth muscle contraction

map04723

Retrograde endocannabinoid signaling

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04921

Oxytocin signaling pathway

map04924

Renin secretion

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04929

GnRH secretion

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05207

Chemical carcinogenesis - receptor activation

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00481

Cone-rod dystrophy and cone dystrophy

H00690

Aland Island eye disease

H00787

Congenital stationary night blindness

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04020 Calcium signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04024 cAMP signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04022 cGMP-PKG signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04929 GnRH secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04912 GnRH signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04921 Oxytocin signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04935 Growth hormone synthesis, secretion and action
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04924 Renin secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04925 Aldosterone synthesis and secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04927 Cortisol synthesis and secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04261 Adrenergic signaling in cardiomyocytes
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04270 Vascular smooth muscle contraction
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09156 Nervous system
   04727 GABAergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04725 Cholinergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04726 Serotonergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04723 Retrograde endocannabinoid signaling
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05020 Prion disease
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05022 Pathways of neurodegeneration - multiple diseases
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05414 Dilated cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F

Other DBs

GO:

0005245

TC:	1.A.1.11.11

Genes

HSA:	778(CACNA1F)

PTR:	740711(CACNA1F)

PPS:	100988624(CACNA1F)

GGO:	101131714(CACNA1F)

PON:	100431752(CACNA1F)

PPYG:

129023840(CACNA1F)

NLE:	100590475(CACNA1F)

HMH:	116811686(CACNA1F)

SSYN:

129475606(CACNA1F)

MCC:	715787(CACNA1F)

MCF:	102119841(CACNA1F)

MTHB:

126945535

MNI:	105493928(CACNA1F)

CSAB:

103231971(CACNA1F)

CATY:

105573107(CACNA1F)

PANU:

101019865(CACNA1F)

TGE:	112614995(CACNA1F)

MLEU:

105547696(CACNA1F)

RRO:	104661816(CACNA1F)

RBB:

108521361

TFN:	117077518(CACNA1F)

CANG:

105514987(CACNA1F)

CJC:	100386041(CACNA1F)

SBQ:	101034685(CACNA1F)

CIMI:

108293049(CACNA1F)

ANAN:

105730410(CACNA1F)

CSYR:

103277252(CACNA1F)

MMUR:

105856433(CACNA1F)

LCAT:

123628833(CACNA1F)

PCOQ:

105816783(CACNA1F)

OGA:	100962519(CACNA1F)

MMU:	54652(Cacna1f)

MCAL:

110286673(Cacna1f)

MPAH:

110313596(Cacna1f)

RNO:	114493(Cacna1f)

MCOC:

116102419(Cacna1f)

ANU:	117695376(Cacna1f)

MUN:	110561910(Cacna1f)

CGE:	100757994(Cacna1f)

MAUA:

101830198(Cacna1f)

PROB:

127218370(Cacna1f)

PLEU:

114701281(Cacna1f)

MORG:

121442677 121444334

MFOT:

126512843

AAMP:

119804579(Cacna1f)

NGI:	103741673(Cacna1f)

HGL:	101722090(Cacna1f)

CPOC:

100720484(Cacna1f)

CCAN:

109697195(Cacna1f)

DORD:

105997824(Cacna1f)

DSP:	122098776(Cacna1f)

PLOP:

125343296(Cacna1f)

NCAR:

124971751

MMMA:

107159825(Cacna1f)

OCU:

100357261

OPI:	101519864(CACNA1F)

TUP:	102482779(CACNA1F)

GVR:	103602700(CACNA1F)

CFA:	480915(CACNA1F)

CLUD:

112673110(CACNA1F)

VVP:	112907237(CACNA1F)

VLG:	121483414(CACNA1F)

NPO:	129517804(CACNA1F)

AML:	100468661(CACNA1F)

UMR:	103667625(CACNA1F)

UAH:	113265950(CACNA1F)

UAR:	123797184(CACNA1F)

ELK:

111150407

LLV:

125091668

MPUF:

101689134(CACNA1F)

MNP:	132007466(CACNA1F)

MLK:	131821118(CACNA1F)

NVS:	122897554(CACNA1F)

ORO:	101364481(CACNA1F)

EJU:	114216787(CACNA1F)

ZCA:	113931031(CACNA1F)

MLX:	118008972(CACNA1F)

NSU:	110570742(CACNA1F)

LWW:	102742095(CACNA1F)

FCA:	101080870(CACNA1F)

PYU:	121026060(CACNA1F)

PCOO:

112871144(CACNA1F)

PBG:	122477612(CACNA1F)

PVIV:

125157244(CACNA1F)

LRUF:

124509536

PTG:	102950547(CACNA1F)

PPAD:

109248097(CACNA1F)

PUC:

125931680

AJU:

106988999

HHV:	120221013(CACNA1F)

BTA:	509779(CACNA1F)

BOM:	102286805(CACNA1F)

BIU:	109554975(CACNA1F)

BBUB:

102407399(CACNA1F)

CHX:	102189746(CACNA1F)

OAS:	101104552(CACNA1F)

BTAX:

128070004(CACNA1F)

ODA:	120881638(CACNA1F)

CCAD:

122434769(CACNA1F)

MBEZ:

129564275(CACNA1F)

SSC:	100514745(CACNA1F)

CFR:	102504151(CACNA1F)

CBAI:

105079415(CACNA1F)

CDK:	105103284(CACNA1F)

VPC:	102540844(CACNA1F)

BACU:

102998540(CACNA1F)

BMUS:

118888578(CACNA1F)

LVE:	103082192(CACNA1F)

OOR:	101281199(CACNA1F)

DLE:	111169490(CACNA1F)

PCAD:

102992313(CACNA1F)

PSIU:

116747382(CACNA1F)

NASI:

112399841(CACNA1F)

ECB:	100062861(CACNA1F)

EPZ:	103543955(CACNA1F)

EAI:	106826963(CACNA1F)

MYB:	102260789(CACNA1F)

MYD:	102771414(CACNA1F)

MMYO:

118654729(CACNA1F)

MLF:	102434312(CACNA1F)

MDT:	132224732(CACNA1F)

PKL:	118731815(CACNA1F)

EFUS:

103301304(CACNA1F)

MNA:	107541372(CACNA1F)

DRO:	112322357(CACNA1F)

SHON:

118998346(CACNA1F)

AJM:	119059521(CACNA1F)

PDIC:

114505705(CACNA1F)

PHAS:

123832713(CACNA1F)

MMF:	118635608(CACNA1F)

PPAM:

129065030(CACNA1F)

HAI:	109374806(CACNA1F)

RFQ:	117023033(CACNA1F)

PALE:

102893611(CACNA1F)

PGIG:

120587067(CACNA1F)

PVP:	105309056(CACNA1F)

RAY:	107514999(CACNA1F)

MJV:	108404213(CACNA1F)

TOD:	119246715(CACNA1F)

SARA:

101548753(CACNA1F)

SETR:

125999147(CACNA1F)

LAV:	100674649(CACNA1F)

TMU:

101340818

ETF:	101662493(CACNA1F)

DNM:	101421427(CACNA1F)

MDO:	100019531(CACNA1F)

SHR:	100927554(CACNA1F)

AFZ:

127543177

PCW:	110201034(CACNA1F)

OAA:	100075939(CACNA1F)

PCOC:

116240105(CACNA1F)

LMUT:

125687783

ACYG:

106029551(CACNA1F)

CATA:

118261499

AFUL:

116501486

LSR:

110482322

PMOA:

120506954(CACNA1F)

OTC:	121339170(CACNA1F)

PRUF:

121362313

FAB:

101817703

OMA:	130263362(CACNA1F)

PHI:	102111116(CACNA1F)

CCW:	120412196(CACNA1F)

CBRC:

103618144

ZLE:	135460883(CACNA1F)

MMEA:

130587072

HRT:	120748203(CACNA1F)

FPG:

101922071

FCH:

102046341

ACHC:

115338229(CACNA1F)

HLE:

104836181

AGEN:

126035178

CLV:

102089966

CUCA:

104065626(CACNA1F)

AAM:	106493905(CACNA1F)

AROW:

112972618

ASN:	102368804(CACNA1F)

AMJ:	102563169(CACNA1F)

CCAY:

125628302

DCC:	119847431(CACNA1F)

CPIC:

101934179

CABI:

116823939

MRV:	120388192(CACNA1F)

ACS:	100565753(cacna1f)

ASAO:

132767858(CACNA1F)

PVT:	110078615(CACNA1F)

SUND:

121920504(CACNA1F)

PBI:	103051695(CACNA1F)

PMUR:

107284195(CACNA1F)

CTIG:

120311308(CACNA1F)

PGUT:

117675658(CACNA1F)

APRI:

131191024(CACNA1F)

PTEX:

113443408(CACNA1F)

NSS:	113417797(CACNA1F)

VKO:	123029960(CACNA1F)

PMUA:

114587594(CACNA1F)

PRAF:

128404904(CACNA1F)

ZVI:	118097569(CACNA1F)

HCG:	128343579(CACNA1F)

GJA:

107117359

STOW:

125428467(CACNA1F)

EMC:	129346029(CACNA1F)

XLA:	100462913(cacna1f.L)

XTR:	100485906(cacna1f)

NPR:

108788491

RTEM:

120913037(CACNA1F)

BBUF:

120977192(CACNA1F)

BGAR:

122919691(CACNA1F)

GSH:	117349072(CACNA1F)

DRE:	559964(cacna1fb) 793708(cacna1fa)

SRX:	107723069 107731232 107745766 107756819

SANH:

107668072 107695300

SGH:	107548248 107549945 107550115

CCAR:

109065543 109087149

CAUA:

113070706 113076440 113079157 113087728

CGIB:

127964170 128018341 128018705

PTET:

122350026(cacna1fa) 122350696(cacna1fb)

LROH:

127169482(cacna1fa) 127169880(cacna1fb)

OMC:	131546303(cacna1fb) 131546383(cacna1fa)

PPRM:

120469151(cacna1fb) 120473866(cacna1fa)

RKG:	130081967(cacna1fa) 130094676(cacna1fb)

MAMB:

125279615(cacna1fb) 125280153(cacna1fa)

CIDE:

127517750 127517829

CERY:

137026362(cacna1fb) 137026591(cacna1fa)

MASI:

127414877 127415138 127424230

TROS:

130567680(cacna1fa) 130567834(cacna1fb)

TDW:	130407254(cacna1fa) 130440415(cacna1fb)

MANU:

129413518(cacna1fa) 129414338(cacna1fb)

IPU:	108265065(cacna1fb) 108265094(cacna1fa)

IFU:	128607445(cacna1fa) 128607852(cacna1fb)

PHYP:

113528653 113533319

SMEO:

124399485(cacna1fa) 124399904(cacna1fb)

TFD:	113656188(cacna1fb) 113656253(cacna1fa)

TVC:	132853295(cacna1fb) 132853808(cacna1fa)

TRN:	134318071(cacna1fa) 134318153(cacna1fb)

AMEX:

103033957(cacna1fb) 103034295(cacna1fa)

CMAO:

118813159(cacna1fb) 118813635(cacna1fa)

EEE:	113578747(cacna1f) 113579098

CHAR:

105893627(cacna1fa) 105898895(cacna1fb)

TRU:	101077620(cacna1f) 101079199

TFS:	130529900 130530283

TNG:	GSTEN00023513G001 GSTEN00026488G001

LCO:	104933125 104935494

TBEN:

117477467(cacna1fa)

CGOB:

115005436 115011426(cacna1f)

PGEO:

117449586

GACU:

117558053 117563145

EMAC:

134868208(cacna1fb) 134870830(cacna1fa)

ELY:	117257982(cacna1fb) 117258407(cacna1fa)

EFO:	125891630(cacna1fa) 125891672(cacna1fb)

PLEP:

121946427

SLUC:

116043571(cacna1fa) 116045489(cacna1fb)

ECRA:

117947003(cacna1fa)

ESP:

116692878

PFLV:

114558250

GAT:	120814961(cacna1fb) 120828763(cacna1fa)

PPUG:

119222360(cacna1fb) 119223125(cacna1fa)

AFB:	129099479(cacna1fa)

CLUM:

117733899(cacna1fa) 117734083(cacna1fb)

PSWI:

130198907(cacna1fb) 130198943(cacna1fa)

MSAM:

119905055(cacna1fb) 119905094(cacna1fa)

SCHU:

122883241(cacna1fb) 122883424(cacna1fa)

CUD:	121516935(cacna1fa) 121517368(cacna1fb)

ALAT:

119022437(cacna1fa) 119023017(cacna1fb)

ASTR:

137589397(cacna1fa) 137602630(cacna1fb)

MZE:	101472797 101480057

ONL:	100700615 100706871

OAU:	116319501(cacna1fa) 116335447(cacna1fb)

OLA:	101171727 101171913

OML:	112158663(cacna1fb) 112158801(cacna1fa)

CSAI:

133456705(cacna1fa) 133456958(cacna1fb)

XMA:	102223947 102230940

XCO:	114141072 114141251

XHE:	116708807 116722696

PRET:

103460216 103467718

PFOR:

103131960 103131961 103139061(cacna1f)

PLAI:

106935811 106942295 106954626(cacna1f)

PMEI:

106909745 106915898(cacna1f)

GAF:	122819169(cacna1fa) 122841771(cacna1fb)

PPRL:

129370128(cacna1fa)

CVG:	107095949(cacna1f) 107099706

CTUL:

119792002(cacna1fb) 119799513(cacna1fa)

GMU:	124867625(cacna1fa) 124868417(cacna1fb)

NFU:	107390498(cacna1f) 107391407

KMR:	108228711 108232078

ALIM:

106519282(cacna1f) 106523414 106533880

NWH:

119417562

AOCE:

111580242

MCEP:

125000377(cacna1fa) 125008328(cacna1fb)

CSEM:

103384398 103385395(cacna1f)

POV:	109642986 109643812

SSEN:

122776983(cacna1fb) 122777519(cacna1fa)

HHIP:

117764489(cacna1fa) 117765247(cacna1fb)

HSP:	118111156(cacna1fb) 118111219(cacna1fa)

PPLT:

128442156(cacna1fb) 128442978(cacna1fa)

SMAU:

118316446(cacna1fb) 118316681(cacna1fa)

LCF:	108882181(cacna1fa) 108890565(cacna1fb)

SDU:	111234857 111235435

SLAL:

111654197 111669629

XGL:	120803456(cacna1fa) 120804054(cacna1fb)

HCQ:	109510493 109512986(cacna1f)

SSCV:

125988118 125989504

SBIA:

133511311(cacna1fb) 133514547

PEE:	133401401(cacna1fa) 133407340(cacna1fb)

PTAO:

133476776(cacna1fa) 133485243(cacna1fb)

BPEC:

110154433 110164475(cacna1f)

MALB:

109953071

BSPL:

114858189(cacna1fb) 114858500(cacna1fa)

SJO:	128357648(cacna1fa) 128357695

SASA:

106572493

STRU:

115166484 115168069

OTW:

112221526

OMY:	110512770(cacna1fb) 110531219

OGO:	124032106 124032399(cacna1fb) 124045931

ONE:	115101902 115132631

OKI:

109869700

OKE:	118359894 118360554 118379413(cacna1fb)

SALP:

111966955

SNH:

120061553

CCLU:

121537216 121538138(cacna1fb) 121546475

ELS:	105008776 105022404

SFM:	108918279 108934768

PKI:	111847817 111857113

AANG:

118207210(cacna1fb) 118210606

PSPA:

121305498

ARUT:

117967960

PSEX:

120542743

LCM:	102353236(CACNA1F)

PMRN:

116952741

» show all

Reference

PMID:25468907

Authors

Lee A, Wang S, Williams B, Hagen J, Scheetz TE, Haeseleer F

Title

Characterization of Cav1.4 complexes (alpha11.4, beta2, and alpha2delta4) in HEK293T cells and in the retina.

Journal

J Biol Chem 290:1505-21 (2015)
DOI:10.1074/jbc.M114.607465

Sequence

[hsa:778]

Reference

PMID:9662399

Authors

Strom TM, Nyakatura G, Apfelstedt-Sylla E, Hellebrand H, Lorenz B, Weber BH, Wutz K, Gutwillinger N, Ruther K, Drescher B, Sauer C, Zrenner E, Meitinger T, Rosenthal A, Meindl A

Title

An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness.

Journal

Nat Genet 19:260-3 (1998)
DOI:10.1038/940

Sequence

[hsa:778]

LinkDB

ORTHOLOGY: K04857

Entry

K04857                      KO

Symbol

CACNA1S, CAV1.1

Name

voltage-dependent calcium channel L type alpha-1S

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04270

Vascular smooth muscle contraction

map04723

Retrograde endocannabinoid signaling

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04921

Oxytocin signaling pathway

map04924

Renin secretion

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04929

GnRH secretion

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05207

Chemical carcinogenesis - receptor activation

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00215

Periodic paralysis

H00746

Hypokalemic periodic paralysis

H01810

Congenital myopathy

H02646

Malignant hyperthermia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04020 Calcium signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04024 cAMP signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04022 cGMP-PKG signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04929 GnRH secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04912 GnRH signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04921 Oxytocin signaling pathway
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04935 Growth hormone synthesis, secretion and action
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04924 Renin secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04925 Aldosterone synthesis and secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04927 Cortisol synthesis and secretion
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04261 Adrenergic signaling in cardiomyocytes
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04270 Vascular smooth muscle contraction
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09156 Nervous system
   04727 GABAergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04725 Cholinergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04726 Serotonergic synapse
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   04723 Retrograde endocannabinoid signaling
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05020 Prion disease
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05022 Pathways of neurodegeneration - multiple diseases
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
   05414 Dilated cardiomyopathy
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S

Other DBs

GO:

0005245

TC:	1.A.1.11.2

Genes

HSA:	779(CACNA1S)

PTR:	469635(CACNA1S)

PPS:	100982136(CACNA1S)

GGO:	101150507(CACNA1S)

PON:	100433948(CACNA1S)

PPYG:

129019696(CACNA1S)

NLE:	100589614(CACNA1S)

HMH:	116457338(CACNA1S)

SSYN:

129458080(CACNA1S)

MCC:	708706(CACNA1S)

MCF:	102131553(CACNA1S)

MTHB:

126939641

MNI:	105484707(CACNA1S)

CSAB:

103230339(CACNA1S)

CATY:

105575216(CACNA1S)

PANU:

101025213(CACNA1S)

TGE:	112625837(CACNA1S)

MLEU:

105547155(CACNA1S)

RRO:	104661868(CACNA1S)

RBB:	108545075(CACNA1S)

TFN:	117076828(CACNA1S)

PTEH:

111550963(CACNA1S)

CANG:

105504320(CACNA1S)

CJC:	100390112(CACNA1S)

SBQ:	101042219(CACNA1S)

CIMI:

108283204(CACNA1S)

ANAN:

105721932(CACNA1S)

CSYR:

103269543(CACNA1S)

MMUR:

105859992(CACNA1S)

LCAT:

123626819(CACNA1S)

PCOQ:

105815312 105826943

OGA:	100962683(CACNA1S)

MMU:	12292(Cacna1s)

MCAL:

110296075(Cacna1s)

MPAH:

110322010(Cacna1s)

RNO:	682930(Cacna1s)

MCOC:

116069682(Cacna1s)

ANU:	117716104(Cacna1s)

MUN:	110548425(Cacna1s)

CGE:	100765508(Cacna1s)

MAUA:

101835763(Cacna1s)

PROB:

127221312(Cacna1s)

PLEU:

114683299(Cacna1s)

MORG:

121444275(Cacna1s)

MFOT:

126505025

AAMP:

119827234(Cacna1s)

NGI:	103731814(Cacna1s)

HGL:	101726232(Cacna1s)

CPOC:

100734741(Cacna1s)

CCAN:

109696593

DORD:

105986412(Cacna1s)

DSP:	122126705(Cacna1s)

PLOP:

125360227(Cacna1s)

NCAR:

124961645

MMMA:

107140653(Cacna1s)

OCU:	100009585(CACNA1S)

OPI:	101529015(CACNA1S)

TUP:	102481015(CACNA1S)

GVR:	103597229(CACNA1S)

CFA:	490244(CACNA1S)

CLUD:

112667091(CACNA1S)

VVP:	112934538(CACNA1S)

VLG:	121493117(CACNA1S)

NPO:	129505985(CACNA1S)

AML:	100472835(CACNA1S)

UMR:	103657769(CACNA1S)

UAH:	113242563(CACNA1S)

UAR:	123785763(CACNA1S)

ELK:

111150995

LLV:

125086002

MPUF:

101688476(CACNA1S)

MNP:	132026153(CACNA1S)

MLK:	131814910(CACNA1S)

NVS:	122918773(CACNA1S)

ORO:	101385947(CACNA1S)

EJU:	114221937(CACNA1S)

ZCA:	113932406(CACNA1S)

MLX:	118014221(CACNA1S)

NSU:	110573862(CACNA1S)

LWW:	102745809(CACNA1S)

FCA:	654399(CACNA1S)

PYU:	121021720(CACNA1S)

PCOO:

112857700(CACNA1S)

PBG:	122476562(CACNA1S)

PVIV:

125155193(CACNA1S)

LRUF:

124510409

PTG:	102949808(CACNA1S)

PPAD:

109256096(CACNA1S)

PUC:

125925380

AJU:

106974264

HHV:	120228884(CACNA1S)

BTA:	100337204(CACNA1S)

BOM:	102272241(CACNA1S)

BBUB:

102397191(CACNA1S)

BBIS:

104981877(CACNA1S)

CHX:	102176151(CACNA1S)

OAS:	101108767(CACNA1S)

BTAX:

128061188(CACNA1S)

ODA:	120880100(CACNA1S)

CCAD:

122452261(CACNA1S)

MBEZ:

129551192(CACNA1S)

SSC:	100622149(CACNA1S)

CFR:	102507309(CACNA1S)

CBAI:

105070011(CACNA1S)

CDK:	105090835(CACNA1S)

VPC:	102528399(CACNA1S)

BACU:

103014409(CACNA1S)

BMUS:

118897154(CACNA1S)

LVE:	103090575(CACNA1S)

OOR:	101275416(CACNA1S)

DLE:	111168340(CACNA1S)

PCAD:

102987099(CACNA1S)

PSIU:

116739924(CACNA1S)

NASI:

112402631(CACNA1S)

ECB:	100034092(CACNA1S)

EPZ:	103565109(CACNA1S)

EAI:	106823553(CACNA1S)

MYB:	102243265(CACNA1S)

MYD:	102760374(CACNA1S)

MMYO:

118678862(CACNA1S)

MDT:	132222573(CACNA1S)

PKL:	118721896(CACNA1S)

EFUS:

103303711(CACNA1S)

MNA:	107536018(CACNA1S)

DRO:	112318756(CACNA1S)

SHON:

119003902(CACNA1S)

AJM:	119060725(CACNA1S)

PDIC:

114512262(CACNA1S)

PHAS:

123832334(CACNA1S)

MMF:	118640543(CACNA1S)

PPAM:

129072943(CACNA1S)

HAI:	109380439(CACNA1S)

RFQ:	117018578(CACNA1S)

PALE:

102896136(CACNA1S)

PGIG:

120619319(CACNA1S)

PVP:	105296936(CACNA1S)

RAY:	107513628(CACNA1S)

MJV:	108396001(CACNA1S)

TOD:	119234060(CACNA1S)

SARA:

101543389(CACNA1S)

SETR:

126004344(CACNA1S)

LAV:	100673089(CACNA1S)

TMU:

101343945

ETF:	101658956(CACNA1S)

DNM:	101431251(CACNA1S)

MDO:	100013684(CACNA1S)

GAS:	123245622(CACNA1S)

SHR:	100917433(CACNA1S)

AFZ:

127562742

PCW:	110219570(CACNA1S)

TVP:	118846041(CACNA1S)

OAA:	100093447(CACNA1S)

GGA:	395985(CATSPER2)

PCOC:

116238729(CACNA1S)

MGP:	100547445(CACNA1S)

CJO:	107324611(CACNA1S)

TPAI:

128090290(CACNA1S)

LMUT:

125683997(CACNA1S)

NMEL:

110388201(CACNA1S)

APLA:

101801311

ACYG:

106046137(CACNA1S)

CATA:

118255291(CACNA1S)

AFUL:

116498683(CACNA1S)

TGU:	100220193(CACNA1S)

LSR:	110469152(CACNA1S)

SCAN:

103822432(CACNA1S)

PMOA:

120503413(CACNA1S)

OTC:	121345503(CACNA1S)

PRUF:

121365422(CACNA1S)

GFR:	102037957(CACNA1S)

FAB:	101821759(CACNA1S)

OMA:	130263593(CACNA1S)

PHI:	102111358(CACNA1S)

PMAJ:

107214754(CACNA1S)

CCAE:

111939717(CACNA1S)

CCW:	104692446(CACNA1S)

CBRC:

103619471(CACNA1S)

ETL:	114064775(CACNA1S)

ZAB:	102072903(CACNA1S)

ZLE:	135458029(CACNA1S)

ACHL:

103797159(CACNA1S)

SVG:	106850939(CACNA1S)

MMEA:

130578832(CACNA1S)

HRT:	120762721(CACNA1S)

SATI:

136371628(CACNA1S)

FPG:	101914764(CACNA1S)

FCH:	102058184(CACNA1S)

CCRI:

104157381(CACNA1S)

NNT:	104413454(CACNA1S)

SHAB:

115602452(CACNA1S)

ACUN:

113488965(CACNA1S)

TALA:

104358095(CACNA1S)

ACHC:

115335203(CACNA1S)

HALD:

104323775(CACNA1S)

HLE:	104842414(CACNA1S)

AGEN:

126052405

GCL:

127026378

CSTI:

104561676(CACNA1S)

LDI:	104344820(CACNA1S)

DPUB:

104309266(CACNA1S)

AVIT:

104278023

BRHI:

104501442(CACNA1S)

EGZ:	104122032(CACNA1S)

NNI:	104011070(CACNA1S)

PCRI:

104028054(CACNA1S)

PADL:

103913818(CACNA1S)

AFOR:

103901091

FGA:	104071045(CACNA1S)

GSTE:

104264447(CACNA1S)

CLV:	102092229(CACNA1S)

MUI:	104543608(CACNA1S)

PGUU:

104465541(CACNA1S)

PLET:

104621942(CACNA1S)

CMAC:

104478656(CACNA1S)

CUCA:

104058982(CACNA1S)

TEO:	104380113(CACNA1S)

BREG:

104639501(CACNA1S)

OHA:	104337830(CACNA1S)

ACAR:

104520524

CPEA:

104390498(CACNA1S)

CVF:	104283174(CACNA1S)

RTD:	128900329(CACNA1S)

AAM:	106500235(CACNA1S)

AROW:

112961842

NPD:	112959119(CACNA1S)

TGT:	104566797(CACNA1S)

DNE:	112983855(CACNA1S)

SCAM:

104139284(CACNA1S)

ASN:	102377229(CACNA1S)

AMJ:	102563699(CACNA1S)

CPOO:

109317585(CACNA1S)

PSS:

102453880

CMY:	114020321(CACNA1S)

CCAY:

125625164(CACNA1S)

DCC:	119846310(CACNA1S)

CPIC:

101932307

CABI:

116837308(CACNA1S)

MRV:	120403655(CACNA1S)

ACS:	100551605(cacna1s)

ASAO:

132773753(CACNA1S)

PVT:	110085291(CACNA1S)

SUND:

121928807(CACNA1S)

PBI:	103055781(CACNA1S)

PMUR:

107289042(CACNA1S)

CTIG:

120298959(CACNA1S)

TSR:	106549619(CACNA1S)

PGUT:

117664028(CACNA1S)

APRI:

131196419(CACNA1S)

PTEX:

113446940 113447751

NSS:	113418846 113418965

VKO:	123024268(CACNA1S)

PMUA:

114599194(CACNA1S)

PRAF:

128415973(CACNA1S)

ZVI:	118088554(CACNA1S)

HCG:	128323424(CACNA1S)

GJA:	107110972(CACNA1S)

STOW:

125433366(CACNA1S)

EMC:	129329616(CACNA1S)

XLA:	100381134(cacna1s.S) 108707491

XTR:	100485035(cacna1s)

NPR:	108804869(CACNA1S)

RTEM:

120927212(CACNA1S)

BBUF:

120995137(CACNA1S)

BGAR:

122933053(CACNA1S)

MUO:	115481344(CACNA1S)

GSH:	117347451(CACNA1S)

DRE:	405791(cacna1sb) 570683(cacna1sa)

SRX:	107707674 107711920

SANH:

107667627 107669632 107679379

SGH:	107550462 107572552 107591792

CCAR:

109068176

CAUA:

113040331 113093954 113107268 113107582

CGIB:

127963663 127987679 128018620

PTET:

122327907(cacna1sa) 122350146(cacna1sb)

LROH:

127162533(cacna1sa) 127169628(cacna1sb)

OMC:	131531222(cacna1sa) 131545431(cacna1sb)

PPRM:

120483504(cacna1sb) 120486533(cacna1sa)

RKG:	130072686(cacna1sa) 130094579(cacna1sb)

MAMB:

125263059(cacna1sa) 125279856(cacna1sb)

CIDE:

127517752 127521648

CERY:

137027151(cacna1sb) 137028262(cacna1sa)

MASI:

127414499 127438377

TROS:

130548631(cacna1sa) 130568290(cacna1sb)

TDW:	130430334(cacna1sa) 130440240(cacna1sb)

MANU:

129413715(cacna1sb) 129453282(cacna1sa)

IPU:	108254927(cacna1sa) 108266034(cacna1sb)

IFU:	128607938(cacna1sb) 128625109(cacna1sa)

PHYP:

113526802(cacna1s)

SMEO:

124400141(cacna1sb) 124402415(cacna1sa)

TFD:	113648899(cacna1sa) 113656001(cacna1sb)

TVC:	132838336(cacna1sa) 132853220(cacna1sb)

TRN:	134301669(cacna1sa) 134318183(cacna1sb)

AMEX:

103022292(cacna1sb) 103036105(cacna1sa)

CMAO:

118799299(cacna1sa) 118813753(cacna1sb)

EEE:	113581084 113586976(cacna1s)

CHAR:

105897327(cacna1sb) 105900081(cacna1sa)

TRU:	101064508 101065120

TFS:	130529418 130540103(cacna1sa)

TNG:	GSTEN00015785G001 GSTEN00028107G001

LCO:	104932670(cacna1s)

NCC:	104956859(cacna1s)

TBEN:

117493994(cacna1sb) 117493999

CGOB:

115007829 115010609

PGEO:

117446411 117449305(cacna1sb)

GACU:

117535431 117541823(cacna1sb)

EMAC:

134870372 134882813

ELY:	117251027 117258405

EFO:	125886092 125891090

PLEP:

121946489

SLUC:

116036694 116039109

ECRA:

117942791 117947748(cacna1sb)

ESP:	116692230(cacna1s)

PFLV:

114553640 114558278

GAT:	120829078(cacna1sb) 120835575

PPUG:

119193902 119221886

AFB:	129099233 129105522

CLUM:

PSWI:

MSAM:

SCHU:

CUD:	121507344 121517507

ALAT:

119020797 119023476

ASTR:

137594839 137602603

MZE:	101479917(cacna1s)

ONL:	100704349(cacna1s)

OAU:

116325819

OLA:	101160313 101170269

OML:	112144928 112159792

CSAI:

133449049 133457197

XMA:	102237099(cacna1s)

XCO:	114148648(cacna1s)

XHE:	116727080(cacna1s)

PRET:

103467335(cacna1s)

PFOR:

103141148(cacna1s)

PLAI:

106935710 106950813(cacna1s)

PMEI:

106920834(cacna1s)

GAF:

122836924

PPRL:

129372226

CVG:	107086768(cacna1s)

CTUL:

119782227

GMU:

124869521

NFU:	107390862(cacna1s)

KMR:

108244587

ALIM:

106525038(cacna1s)

NWH:

119417628

AOCE:

111564440(cacna1s) 111586752

MCEP:

125006895

CSEM:

103385091 103386795

POV:	109630550(cacna1s)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108876486 108877469

SDU:	111219219 111221701

SLAL:

111668619 111668912

XGL:	120804406 120807109

HCQ:	109521358 109531393

SSCV:

125977722 125988514

SBIA:

133505669 133507006

PEE:	133402394 133408910

PTAO:

133478597 133483173

BPEC:

110164965(cacna1s)

MALB:

109968827(cacna1s)

BSPL:

114858880

SJO:

128357450

SASA:

106565294 106567031 106583479

STRU:

115150281 115167827 115208150

OTW:

112221688

OMY:	110491948 110494953 110528387

OGO:	124003446 124028741 124046106

ONE:	115102692 115142918

OKI:	109869670 109885052 109891316 109899957

OKE:	118360125 118389361 118399696

SALP:

111962608 111970366 111976724

SNH:	120021753 120060984 120064811

CCLU:

121545876 121575422 121578080

ELS:	105013561 105016828

SFM:	108931184 108933625(cacna1s)

PKI:	111834368 111858929

AANG:

118208634 118210591(cacna1sa)

LOC:	102684448(cacna1s)

PSPA:

121299863 121299885

ARUT:

117396463 117430530

PSEX:

120525930

LCM:	102356715(CACNA1S)

CMK:

103190861

RTP:

109922317

CPLA:

122562953

HOC:	132828476(cacna1sa)

LERI:

PMRN:

LRJ:

PPOI:

HSY:

RES:

PTM:	GSPATT00027650001 GSPATT00029652001

» show all

Reference

PMID:20861472

Authors

Pirone A, Schredelseker J, Tuluc P, Gravino E, Fortunato G, Flucher BE, Carsana A, Salvatore F, Grabner M

Title

Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit.

Journal

Am J Physiol Cell Physiol 299:C1345-54 (2010)
DOI:10.1152/ajpcell.00008.2010

Sequence

[hsa:779]

Reference

PMID:8004673

Authors

Ptacek LJ, Tawil R, Griggs RC, Engel AG, Layzer RB, Kwiecinski H, McManis PG, Santiago L, Moore M, Fouad G, et al.

Title

Dihydropyridine receptor mutations cause hypokalemic periodic paralysis.

Journal

Cell 77:863-8 (1994)
DOI:10.1016/0092-8674(94)90135-X

Sequence

[hsa:779]

LinkDB

ORTHOLOGY: K04862

Entry

K04862                      KO

Symbol

CACNB1

Name

voltage-dependent calcium channel beta-1

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04862  CACNB1; voltage-dependent calcium channel beta-1
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04862  CACNB1; voltage-dependent calcium channel beta-1
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04862  CACNB1; voltage-dependent calcium channel beta-1
   04261 Adrenergic signaling in cardiomyocytes
    K04862  CACNB1; voltage-dependent calcium channel beta-1
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04862  CACNB1; voltage-dependent calcium channel beta-1
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04862  CACNB1; voltage-dependent calcium channel beta-1
   05414 Dilated cardiomyopathy
    K04862  CACNB1; voltage-dependent calcium channel beta-1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04862  CACNB1; voltage-dependent calcium channel beta-1
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04862  CACNB1; voltage-dependent calcium channel beta-1

Other DBs

GO:

0005245

TC:	8.A.22.1.1

Genes

HSA:	782(CACNB1)

PTR:	454624(CACNB1)

PPS:	100993307(CACNB1)

GGO:	109025142(CACNB1)

PON:	100456553(CACNB1)

PPYG:

129017136(CACNB1)

NLE:	100599778(CACNB1)

HMH:	116474744(CACNB1)

SSYN:

129470333(CACNB1)

MCC:	695864(CACNB1)

MCF:	102131958(CACNB1)

MTHB:

126938447

MNI:	105472260(CACNB1)

CSAB:

103243548(CACNB1)

CATY:

105579539(CACNB1)

PANU:

100999288(CACNB1)

TGE:	112610281(CACNB1)

MLEU:

105542995(CACNB1)

RRO:	104674863(CACNB1)

RBB:	108533973(CACNB1)

TFN:	117067107(CACNB1)

PTEH:

111537479(CACNB1)

CANG:

105503132(CACNB1)

CJC:	100387356(CACNB1)

SBQ:	101048339(CACNB1)

CIMI:

108281604(CACNB1)

ANAN:

105717013(CACNB1)

CSYR:

103269223

MMUR:

105872117(CACNB1)

LCAT:

123620820(CACNB1)

PCOQ:

105823878(CACNB1)

OGA:	100958249(CACNB1)

MMU:	12295(Cacnb1)

MCAL:

110304211(Cacnb1)

MPAH:

110332782(Cacnb1)

RNO:	50688(Cacnb1)

MCOC:

116077033(Cacnb1)

ANU:	117710687(Cacnb1)

MUN:	110554278(Cacnb1)

CGE:	100757399(Cacnb1)

MAUA:

101838500(Cacnb1)

PROB:

127215172(Cacnb1)

PLEU:

114706913(Cacnb1)

MORG:

121442316 121456214

MFOT:

126510509

AAMP:

119811413(Cacnb1)

NGI:	103743810(Cacnb1)

HGL:	101714578(Cacnb1)

CPOC:

100721141(Cacnb1)

CCAN:

109691957(Cacnb1)

DORD:

106002684(Cacnb1)

DSP:	122103511(Cacnb1)

PLOP:

125365807(Cacnb1)

NCAR:

124980591

MMMA:

107160036(Cacnb1)

OCU:	100009109(CACNB1)

OPI:	101524421(CACNB1)

TUP:	102475272(CACNB1)

GVR:	103591194(CACNB1)

CFA:	491030(CACNB1)

CLUD:

112655098(CACNB1)

VVP:	112917793(CACNB1)

VLG:	121473900(CACNB1)

NPO:	129515391(CACNB1)

AML:	100469411(CACNB1)

UMR:	103661404(CACNB1)

UAH:	113265527(CACNB1)

UAR:	123779537(CACNB1)

ELK:

111151650

LLV:

125087304

MPUF:

101677145(CACNB1)

MNP:	132003132(CACNB1)

MLK:	131816414(CACNB1)

NVS:	122906308(CACNB1)

ORO:	101369484(CACNB1)

EJU:	114198503(CACNB1)

ZCA:	113939636(CACNB1)

MLX:	118024835(CACNB1)

NSU:	110593075(CACNB1)

LWW:	102736493(CACNB1)

FCA:	101089057(CACNB1)

PYU:	121044899(CACNB1)

PCOO:

112854031(CACNB1)

PBG:	122485467(CACNB1)

PVIV:

125158531(CACNB1)

LRUF:

124512883

PTG:

102958190

PPAD:

109247407(CACNB1)

PUC:

125926472

AJU:

106980467

HHV:	120229015(CACNB1)

BTA:	327703(CACNB1)

BOM:	102287719(CACNB1)

BIU:	109574047(CACNB1)

BBUB:

102391598(CACNB1)

BBIS:

104990547(CACNB1)

CHX:	102178206(CACNB1)

OAS:	101122960(CACNB1)

BTAX:

128065237(CACNB1)

ODA:	120867230(CACNB1)

MBEZ:

129544343(CACNB1)

SSC:	100514316(CACNB1)

CFR:	102522951(CACNB1)

CBAI:

105073272(CACNB1)

CDK:	105099052(CACNB1)

VPC:	102535867(CACNB1)

BACU:

103017826

BMUS:

118887157(CACNB1)

LVE:	103070949(CACNB1)

OOR:	101279094(CACNB1)

DLE:	111166330(CACNB1)

PCAD:

102995288(CACNB1)

PSIU:

116746058(CACNB1)

NASI:

112399975(CACNB1)

ECB:	100055054(CACNB1)

EPZ:	103552950(CACNB1)

EAI:	106826374(CACNB1)

MYB:	102247800(CACNB1)

MYD:	102757287(CACNB1)

MMYO:

118672198(CACNB1)

MLF:	102426847(CACNB1)

MDT:	132218933(CACNB1)

PKL:	118702187(CACNB1)

EFUS:

103297130(CACNB1)

MNA:	107529017(CACNB1)

DRO:	112316240(CACNB1)

SHON:

118978051(CACNB1)

AJM:	119045774(CACNB1)

PDIC:

114503277(CACNB1)

PHAS:

123817470(CACNB1)

MMF:	118634439(CACNB1)

PPAM:

129086875(CACNB1)

HAI:	109380817(CACNB1)

RFQ:	117013064(CACNB1)

PALE:

102888950(CACNB1)

PGIG:

120611206(CACNB1)

PVP:	105308383(CACNB1)

RAY:	107520701(CACNB1)

MJV:	108383696(CACNB1)

TOD:	119230560(CACNB1)

SARA:

101537991(CACNB1)

SETR:

126017373(CACNB1)

LAV:	104846285(CACNB1)

TMU:

101351330

ETF:	101663627(CACNB1)

DNM:	101424130(CACNB1)

MDO:	100017883(CACNB1)

GAS:	123247361(CACNB1)

SHR:	100929328(CACNB1)

AFZ:

127560227

PCW:	110215900(CACNB1)

TVP:	118846480(CACNB1)

OAA:	100079910(CACNB1)

GGA:	777366(CACNB1)

PCOC:

116233650(CACNB1)

MGP:	104914600 104914601

CJO:	107325250(CACNB1)

TPAI:

128089042(CACNB1)

LMUT:

125684739(CACNB1)

NMEL:

110388410(CACNB1)

ACYG:

136786764(CACNB1)

AFUL:

116498268(CACNB1)

TGU:	115490678(CACNB1)

LSR:	110481912(CACNB1)

PMOA:

120496645(CACNB1)

OTC:	121347543(CACNB1)

PRUF:

121351096(CACNB1)

OMA:	130264208(CACNB1)

PHI:	102109689(CACNB1)

CCW:	120411371(CACNB1)

ZLE:	135458526(CACNB1)

SVG:	106858597(CACNB1)

MMEA:

130587369(CACNB1)

HRT:	120763826(CACNB1)

SATI:

136372280(CACNB1)

SHAB:

115617734(CACNB1)

TALA:

116959848(CACNB1)

ACHC:

115344542(CACNB1)

HLE:	104843007(CACNB1)

AGEN:

126038688

GCL:

127026434

CUCA:

104055571(CACNB1)

RTD:	128919387(CACNB1)

AROW:

112969533(CACNB1)

NPD:	112960203(CACNB1)

DNE:	112991892(CACNB1)

SCAM:

104148096(CACNB1)

ASN:	102373138(CACNB1)

AMJ:	102559323(CACNB1)

CPOO:

109320265(CACNB1)

GGN:	109290718(CACNB1)

PSS:	102445240(CACNB1)

CMY:	102944895(CACNB1)

CCAY:

125626912(CACNB1)

DCC:	119849071(CACNB1)

CPIC:

101945023(CACNB1)

TST:	117869289(CACNB1)

CABI:

116831394(CACNB1)

MRV:	120392202(CACNB1)

ACS:	100564526(cacnb1)

ASAO:

132778293(CACNB1)

PVT:	110082050(CACNB1)

SUND:

121934654(CACNB1)

PBI:	103058352(CACNB1)

PMUR:

107303060(CACNB1)

CTIG:

120315147(CACNB1)

TSR:	106551158(CACNB1)

PGUT:

117664687(CACNB1)

APRI:

131196633(CACNB1)

PTEX:

113447383(CACNB1)

NSS:	113420025(CACNB1)

VKO:	123031759(CACNB1)

PMUA:

114582760(CACNB1)

PRAF:

128398635(CACNB1)

ZVI:	118094447(CACNB1)

HCG:	128330409(CACNB1)

GJA:	107118450(CACNB1)

STOW:

125444700(CACNB1)

EMC:	129338483(CACNB1)

XLA:	100127255(cacnb1.S) 108700783(cacnb1.L)

XTR:	100158521(cacnb1)

NPR:	108790734(CACNB1)

RTEM:

120918821(CACNB1)

BBUF:

121004747(CACNB1)

BGAR:

122940663(CACNB1)

MUO:	115481557(CACNB1)

GSH:	117347714(CACNB1)

DRE:	436925(cacnb1)

SRX:	107745946 107755015

SANH:

107670911 107689043

SGH:	107552492 107567406(cacnb1)

CAUA:

113043553(cacnb1) 113046907

CGIB:

127947776 127953709

PTET:

122341548 122341678(cacnb1)

LROH:

127162534(cacnb1)

OMC:	131536337(cacnb1)

PPRM:

120489665(cacnb1)

RKG:	130075268(cacnb1)

MAMB:

125279347(cacnb1)

CIDE:

127508001

CERY:

137017468(cacnb1)

MASI:

127450297 127451442

TROS:

130561343(cacnb1)

TDW:	130426347(cacnb1)

MANU:

129436270(cacnb1)

IPU:

108260503

IFU:	128601682(cacnb1)

PHYP:

113528244(cacnb1)

SMEO:

124396797(cacnb1)

TFD:

113641169

TVC:	132861083(cacnb1)

TRN:	134335840(cacnb1)

AMEX:

103034298(cacnb1)

CMAO:

118821080(cacnb1)

EEE:	113580207(cacnb1)

CHAR:

105890760(cacnb1)

TRU:	101075736(cacnb1)

TFS:	130515361(cacnb1)

TNG:	GSTEN00004325G001

LCO:	104926344(cacnb1)

NCC:	104959534(cacnb1)

TBEN:

117493285(cacnb1)

CGOB:

115011732(cacnb1)

PGEO:

117450761(cacnb1)

GACU:

117548455(cacnb1)

EMAC:

134878434(cacnb1)

ELY:

117268247

EFO:	125879979(cacnb1)

PLEP:

121956182(cacnb1)

SLUC:

116063852(cacnb1)

ECRA:

117958423(cacnb1)

ESP:	116702769(cacnb1)

PFLV:

114569057(cacnb1)

GAT:	120827592(cacnb1)

PPUG:

119220013(cacnb1)

AFB:	129097862(cacnb1)

CLUM:

117735445(cacnb1)

PSWI:

130188864(cacnb1)

MSAM:

119893031(cacnb1)

SCHU:

122869143(cacnb1)

CUD:	121529432(cacnb1)

ALAT:

119013883

ASTR:

137609152(cacnb1)

MZE:	101472736(cacnb1)

ONL:	100708961(cacnb1)

OAU:	116314374(cacnb1)

OLA:	101157217(cacnb1)

OML:	112146409(cacnb1)

CSAI:

133422615(cacnb1)

XMA:	102219115(cacnb1)

XCO:	114160070(cacnb1)

XHE:	116735320(cacnb1)

PRET:

103469350(cacnb1)

PFOR:

103142138(cacnb1)

PLAI:

106953280(cacnb1)

PMEI:

106908864(cacnb1)

GAF:	122821743(cacnb1)

PPRL:

129373926(cacnb1)

CVG:	107084813(cacnb1)

CTUL:

119782882(cacnb1)

GMU:	124862971 124864790

NFU:	107378565(cacnb1)

KMR:	108237774(cacnb1)

ALIM:

106534934(cacnb1)

NWH:	119421878(cacnb1)

AOCE:

111574242(cacnb1)

MCEP:

124997565(cacnb1)

CSEM:

103392742

POV:	109634040(cacnb1)

SSEN:

122785155(cacnb1)

HHIP:

117767037(cacnb1)

HSP:	118122938(cacnb1)

PPLT:

128459213(cacnb1)

SMAU:

118288273(cacnb1)

LCF:

108872768

SDU:	111217509(cacnb1)

SLAL:

111658461

XGL:	120788015(cacnb1)

HCQ:	109519308(cacnb1)

SSCV:

125983710

SBIA:

133514100(cacnb1)

PEE:	133415116(cacnb1)

PTAO:

133465810(cacnb1)

BPEC:

110159276(cacnb1)

MALB:

109963145

BSPL:

114859912(cacnb1)

SJO:	128379467(cacnb1)

SASA:

106600985 106607253

STRU:

115171068 115197491

OTW:	112225960 112258605

OMY:	110486218(cacnb1) 110538146

OGO:

123999246

ONE:	115104092 115110240

OKI:	109893290 109898387

OKE:

118365240

SALP:

111980767 111981289

SNH:	120034351 120044523

CCLU:

121569504 121569619

ELS:	105013307(cacnb1)

SFM:	108919588 108941755

PKI:	111855959(cacnb1)

AANG:

118216775 118221569

LOC:	102697641(cacnb1)

PSPA:

121302005 121302007 121324486

ARUT:

117433454 117434894 117971288

PSEX:

120517339(cacnb1)

LCM:	102347441(CACNB1)

CMK:	103190066(cacnb1)

RTP:	109931490(cacnb1)

CPLA:

122539790(cacnb1)

HOC:	132830894(cacnb1)

LERI:

129710085(cacnb1)

» show all

Reference

PMID:7916667

Authors

Collin T, Wang JJ, Nargeot J, Schwartz A

Title

Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart.

Journal

Circ Res 72:1337-44 (1993)
DOI:10.1161/01.RES.72.6.1337

Sequence

[hsa:782]

LinkDB

ORTHOLOGY: K04863

Entry

K04863                      KO

Symbol

CACNB2

Name

voltage-dependent calcium channel beta-2

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00728

Brugada syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04863  CACNB2; voltage-dependent calcium channel beta-2
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04863  CACNB2; voltage-dependent calcium channel beta-2
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04863  CACNB2; voltage-dependent calcium channel beta-2
   04261 Adrenergic signaling in cardiomyocytes
    K04863  CACNB2; voltage-dependent calcium channel beta-2
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04863  CACNB2; voltage-dependent calcium channel beta-2
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04863  CACNB2; voltage-dependent calcium channel beta-2
   05414 Dilated cardiomyopathy
    K04863  CACNB2; voltage-dependent calcium channel beta-2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04863  CACNB2; voltage-dependent calcium channel beta-2
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04863  CACNB2; voltage-dependent calcium channel beta-2

Other DBs

GO:

0005245

TC:	8.A.22.1.2

Genes

HSA:	783(CACNB2)

PTR:	740138(CACNB2)

PPS:	100977977(CACNB2)

GGO:	101142555(CACNB2)

PON:	100172479(CACNB2)

PPYG:

129044882(CACNB2)

NLE:	100580212(CACNB2)

HMH:	116476036(CACNB2)

SSYN:

129491972(CACNB2)

MCC:	701226(CACNB2)

MCF:	102130815(CACNB2)

MTHB:

126962937

MNI:	105488234(CACNB2)

CSAB:

103237964(CACNB2)

CATY:

105583823(CACNB2)

PANU:

101013479(CACNB2)

TGE:	112631593(CACNB2)

MLEU:

105531086(CACNB2)

RRO:	104662886(CACNB2)

RBB:	108527755(CACNB2)

TFN:	117082612(CACNB2)

PTEH:

111549941(CACNB2)

CANG:

105527536(CACNB2)

CJC:	100410704(CACNB2)

SBQ:	101048438(CACNB2)

CIMI:

108305213(CACNB2)

ANAN:

105726142(CACNB2)

CSYR:

103257552(CACNB2)

MMUR:

105862389(CACNB2)

LCAT:

123625737(CACNB2)

PCOQ:

105823690(CACNB2)

OGA:	100947015(CACNB2)

MMU:	12296(Cacnb2)

MCAL:

110290272(Cacnb2)

MPAH:

110318390(Cacnb2)

RNO:	116600(Cacnb2)

MCOC:

116089728(Cacnb2)

ANU:	117713497(Cacnb2)

MUN:	110541719(Cacnb2)

CGE:	100774766(Cacnb2)

MAUA:

101825511(Cacnb2)

PROB:

127237369(Cacnb2)

PLEU:

114693931(Cacnb2)

MORG:

121432546(Cacnb2)

MFOT:

126503206

AAMP:

119816251(Cacnb2)

NGI:	103726514(Cacnb2)

HGL:	101713647(Cacnb2)

CPOC:

100192393(Cacnb2)

CCAN:

109700367(Cacnb2)

DORD:

105984496(Cacnb2)

DSP:	122113099(Cacnb2)

PLOP:

125367239(Cacnb2)

NCAR:

124961976

MMMA:

107140389(Cacnb2)

OCU:	100009277(CACNB2)

OPI:	101520306(CACNB2)

TUP:	102473215(CACNB2)

GVR:	103588190(CACNB2)

CFA:	487113(CACNB2)

CLUD:

112659104(CACNB2)

VVP:	112932853(CACNB2)

VLG:	121497843(CACNB2)

NPO:	129513497(CACNB2)

AML:	100476165(CACNB2)

UMR:	103664216(CACNB2)

UAH:	113241360(CACNB2)

UAR:	123785661(CACNB2)

ELK:

111155505

LLV:

125107988

MPUF:

101674245(CACNB2)

MNP:	132020126(CACNB2)

MLK:	131838211(CACNB2)

NVS:	122891452(CACNB2)

ORO:	101384101(CACNB2)

EJU:	114217334(CACNB2)

ZCA:	113922200(CACNB2)

MLX:	118021523(CACNB2)

NSU:	110586569(CACNB2)

LWW:	102725911(CACNB2)

FCA:	101093028(CACNB2)

PYU:	121014746(CACNB2)

PCOO:

112867395(CACNB2)

PBG:	122473743(CACNB2)

PVIV:

125169587(CACNB2)

LRUF:

124501064

PTG:	102965296(CACNB2)

PPAD:

109273668(CACNB2)

PUC:

125919993

AJU:

106979869

HHV:	120240969(CACNB2)

BTA:	327667(CACNB2)

BOM:	102284956(CACNB2)

BIU:	109567989(CACNB2)

BBIS:

105003053(CACNB2)

CHX:	102182803(CACNB2)

OAS:	101112498(CACNB2)

BTAX:

128058156(CACNB2)

ODA:	120869026(CACNB2)

CCAD:

122448067(CACNB2)

MBEZ:

129558402(CACNB2)

SSC:	100524101(CACNB2)

CFR:	102521435(CACNB2)

CBAI:

105079228(CACNB2)

CDK:

105105423

VPC:	102537235(CACNB2)

BACU:

103013626(CACNB2)

BMUS:

118889979(CACNB2)

LVE:	103079439(CACNB2)

OOR:	101285970(CACNB2)

DLE:	111178115(CACNB2)

PCAD:

102978810(CACNB2)

PSIU:

116748886(CACNB2)

NASI:

112402874(CACNB2)

ECB:	100055971(CACNB2)

EPZ:	103558314(CACNB2)

EAI:	106834416(CACNB2)

MYB:	102243843(CACNB2)

MYD:	102767759(CACNB2)

MMYO:

118674183(CACNB2)

MLF:	102436167(CACNB2)

MDT:	132213655(CACNB2)

PKL:	118731029(CACNB2)

EFUS:

103292593(CACNB2)

MNA:	107537293(CACNB2)

DRO:	112318863(CACNB2)

SHON:

118997150(CACNB2)

AJM:	119058829(CACNB2)

PDIC:

114491704(CACNB2)

PHAS:

123831013(CACNB2)

MMF:	118625204(CACNB2)

PPAM:

129086480(CACNB2)

HAI:	109393559(CACNB2)

RFQ:	117019144(CACNB2)

PALE:

102881523(CACNB2)

PGIG:

120614654(CACNB2)

PVP:	105294917(CACNB2)

RAY:	107513663(CACNB2)

MJV:	108392845(CACNB2)

TOD:	119244728(CACNB2)

SARA:

101541161(CACNB2)

SETR:

126014465(CACNB2)

LAV:	100673091(CACNB2)

TMU:

101348272

ETF:	101647286(CACNB2)

DNM:	101418675(CACNB2)

MDO:	100020184(CACNB2)

GAS:	123249370(CACNB2)

SHR:	100928393(CACNB2)

AFZ:

127564291

PCW:	110194513(CACNB2)

TVP:	118850028(CACNB2)

OAA:	100078312(CACNB2)

GGA:	428420(CACNB2)

PCOC:

116243325(CACNB2)

MGP:	100548341(CACNB2)

CJO:	107309036(CACNB2)

TPAI:

128087396(CACNB2)

LMUT:

125695684(CACNB2)

NMEL:

110394912(CACNB2)

APLA:

101802285(CACNB2)

ACYG:

106030338(CACNB2)

CATA:

118247429(CACNB2)

AFUL:

116485907(CACNB2)

TGU:	100232478(CACNB2)

LSR:	110476210(CACNB2)

SCAN:

103812781(CACNB2)

PMOA:

120500757(CACNB2)

OTC:	121337974(CACNB2)

PRUF:

121363965(CACNB2)

GFR:	102038997(CACNB2)

FAB:	101815577(CACNB2)

OMA:	130248884(CACNB2)

PHI:	102106096(CACNB2)

PMAJ:

107199944(CACNB2)

CCAE:

111924154(CACNB2)

CCW:	104689353(CACNB2)

CBRC:

103612330(CACNB2)

ETL:	114062464(CACNB2)

ZAB:	102062816(CACNB2)

ZLE:	135443677(CACNB2)

SVG:	106861294(CACNB2)

MMEA:

130583904(CACNB2)

HRT:	120750572(CACNB2)

SATI:

136359644(CACNB2)

FPG:	101915262(CACNB1) 101916622(CACNB2)

FCH:	102052181(CACNB2)

CCRI:

104159510(CACNB2)

NNT:	104411015(CACNB2)

SHAB:

115603896(CACNB2)

ACUN:

113476569(CACNB2)

TALA:

104363969(CACNB2)

ACHC:

115339666(CACNB2)

HALD:

104321712(CACNB2)

HLE:	104838623(CACNB2)

AGEN:

126038064

GCL:

127013396

LDI:	104352136(CACNB2)

MNB:	103775759(CACNB2)

DPUB:

104296374(CACNB2)

AVIT:

104274539(CACNB2)

EGZ:	104135611(CACNB2)

NNI:	104013320(CACNB2)

PCRI:

104038234(CACNB2)

PADL:

103922416(CACNB2)

AFOR:

103895592(CACNB2)

FGA:	104072929(CACNB2)

GSTE:

104261033(CACNB2)

CLV:	102089586(CACNB2)

MUI:	104537608(CACNB2)

PGUU:

104471272(CACNB2)

EHS:	104510372(CACNB2)

CMAC:

104484209(CACNB2)

CUCA:

104057661(CACNB2)

TEO:	104383219(CACNB2)

BREG:

104643144(CACNB2)

OHA:	104332497(CACNB2)

ACAR:

104530869(CACNB2)

CPEA:

104397037(CACNB2)

CVF:	104288335(CACNB2)

RTD:	128906214(CACNB2)

AAM:	106489927(CACNB2)

AROW:

112969079(CACNB2)

NPD:	112947361(CACNB2)

TGT:	104578376(CACNB2)

DNE:	112982307(CACNB2)

SCAM:

104143275(CACNB2)

ASN:	102375556(CACNB2)

AMJ:	102559343(CACNB2)

CPOO:

109308093(CACNB2)

GGN:	109291344(CACNB2)

PSS:	102445882(CACNB2)

CMY:	102933784(CACNB2)

CCAY:

125631376(CACNB2)

DCC:	119851382(CACNB2)

CPIC:

101944953(CACNB2)

TST:	117872151(CACNB2)

CABI:

116823185(CACNB2)

MRV:	120397991(CACNB2)

ACS:	100552594(cacnb2)

ASAO:

132778896(CACNB2)

PVT:	110090122(CACNB2)

SUND:

121934223(CACNB2)

PBI:	103048210(CACNB2)

PMUR:

107286931(CACNB2)

CTIG:

120302761(CACNB2)

TSR:	106545850(CACNB2)

PGUT:

117654964(CACNB2)

APRI:

131197764(CACNB2)

PTEX:

113446447(CACNB2)

NSS:	113424623(CACNB2)

VKO:	123020722(CACNB2)

PMUA:

114607133(CACNB2)

PRAF:

128398413(CACNB2)

ZVI:	118092114(CACNB2)

HCG:	128329167(CACNB2)

GJA:	107113294(CACNB2)

STOW:

125440699(CACNB2)

EMC:	129337626(CACNB2)

XLA:	108718812(cacnb2.L) 108719866(cacnb2.S)

XTR:	100495884(cacnb2)

NPR:	108793363(CACNB2)

RTEM:

120939987(CACNB2)

BBUF:

121002864(CACNB2)

BGAR:

122938163 122938319(CACNB2)

MUO:	115467970(CACNB2)

GSH:	117354216(CACNB2)

DRE:	795492(cacnb2a)

SRX:	107713974 107728655(cacnb2) 107745300 107751551

SANH:

107664070 107675417 107686054 107691825

SGH:	107558158 107559955 107601146

CCAR:

109057148 109086954 109094194 109103599 109112913

CAUA:

113045722 113051720 113072739 113106401 113118097

CGIB:

127961472 128016436

PTET:

122348623(cacnb2a)

LROH:

127167968(cacnb2a)

OMC:	131544229(cacnb2a)

RKG:	130090468(cacnb2a)

MAMB:

125265204(cacnb2a)

CIDE:

127515831

CERY:

137030029(cacnb2a)

MASI:

127426449 127450232

TROS:

130553952(cacnb2a)

TDW:	130416456(cacnb2a)

MANU:

129453445(cacnb2a)

IPU:	108267179(cacnb2b) 108268172(cacnb2a)

IFU:	128609629(cacnb2a)

PHYP:

113540116 113540417

SMEO:

124386709(cacnb2a)

TFD:	113657508(cacnb2a)

TVC:	132848422(cacnb2a)

TRN:	134311882(cacnb2a)

AMEX:

103027860(cacnb2b) 103035300(cacnb2a)

CMAO:

118826609

EEE:	113580171 113583190(cacnb2)

CHAR:

122129424(cacnb2a)

TRU:	101072175(cacnb2)

TFS:	130514201(cacnb2a)

TNG:	GSTEN00031767G001

LCO:	104926193 104929564(cacnb2)

NCC:	104945352(cacnb2)

TBEN:

117496834(cacnb2a)

CGOB:

115025303(cacnb2)

PGEO:

117465600(cacnb2a)

GACU:

117544691(cacnb2a)

EMAC:

134884024(cacnb2a)

ELY:	117264874(cacnb2a)

EFO:	125881613(cacnb2a)

PLEP:

121960430(cacnb2a)

SLUC:

116045338(cacnb2a)

ECRA:

117937674(cacnb2a)

ESP:	116672351(cacnb2)

PFLV:

114548817(cacnb2)

GAT:	120812037(cacnb2a)

PPUG:

119198946(cacnb2a)

AFB:	129110854(cacnb2a)

CLUM:

117749788(cacnb2a)

PSWI:

130206103(cacnb2a)

MSAM:

119901900(cacnb2b) 119910985(cacnb2a)

SCHU:

122867053(cacnb2a)

CUD:	121527155(cacnb2a)

ALAT:

119008355(cacnb2a)

ASTR:

137614192(cacnb2a)

MZE:	101477065(cacnb2)

ONL:	100694840(cacnb2)

OAU:	116314501(cacnb2a)

OLA:	101161015(cacnb2)

OML:	112151152(cacnb2a)

CSAI:

133422927(cacnb2a)

XMA:	102230263(cacnb2)

XCO:	114137042(cacnb2)

XHE:	116711941(cacnb2)

PRET:

103456876(cacnb2)

PFOR:

103140478(cacnb2)

PLAI:

106961922(cacnb2)

PMEI:

106915366(cacnb2)

GAF:	122824294(cacnb2a)

PPRL:

129364751(cacnb2a)

CVG:	107086502(cacnb2)

CTUL:

119791713(cacnb2a)

GMU:	124857852(cacnb2a)

NFU:	107382497(cacnb2)

KMR:	108230434(cacnb2a)

ALIM:

106520966(cacnb2)

NWH:	119426756(cacnb2a)

AOCE:

111565079 111583298(cacnb2)

MCEP:

124995576(cacnb2a)

CSEM:

103377464(cacnb2)

POV:	109629793(cacnb2) 109638934

SSEN:

122761051(cacnb2a)

HHIP:

117753802(cacnb2a)

HSP:	118098850(cacnb2a)

PPLT:

128425548(cacnb2a)

SMAU:

118291073(cacnb2a)

LCF:	108883268(cacnb2b) 108896293(cacnb2a)

SDU:	111231115 111237821(cacnb2)

SLAL:

111653165 111665163

XGL:	120790126(cacnb2a) 120798439(cacnb2b)

HCQ:	109529842(cacnb2)

SSCV:

125986238

SBIA:

133492556(cacnb2a)

PEE:	133396207(cacnb2a)

PTAO:

133470143(cacnb2a)

BPEC:

110164100 110170112(cacnb2)

MALB:

109951756(cacnb2) 109955415

BSPL:

114853646(cacnb2a)

SJO:	128382822(cacnb2a)

SASA:

100380803(cacb2) 106578706

STRU:

115154461 115195803(cacnb2)

OTW:	112215649 112227979(cacnb2a)

OMY:	110489951(cacnb2a) 110535617

OGO:

123991086

ONE:	115105159 115130386(cacnb2)

OKI:	109899494 109909321

OKE:	118361508 118373708(cacnb2a)

SALP:

111953390(cacnb2) 111973182

SNH:	120027642 120051157

CCLU:

121550009 121569874

ELS:	105031374(cacnb2)

SFM:	108937087(cacnb2)

PKI:	111834279(cacnb2) 111852554

AANG:

118225515(cacnb2a)

LOC:	102690009(cacnb2)

PSPA:

121312688 121314145

ARUT:

117394663 117400251 117972344

PSEX:

120530097

LCM:	102354424(CACNB2)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116937724 116941130 116943854 116949182

LRJ:	133344697 133346189 133355996

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG42403(Ca-beta)

DER:

6542646

DSI:	Dsimw501_GD22184(Dsim_GD22184)

DYA:	Dyak_GE12954

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18146

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:	108358421 108365171

AOQ:

TDA:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ008078

CPII:

CNS:

BCOO:

LLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105676335(Ca-beta)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

DCOR:

135795175(Ca-beta)

APLN:

PPYR:

OTU:

BMAN:

MSEX:

DPL:	KGM_210937

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110381336 135116980

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:	107168906 107170347

AGS:

114119648

RMD:	113548987 113559322

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

106691184(Ca-beta)

NLU:

111054417

HVI:

124364667

MQU:

129001447

PHU:	Phum_PHUM411240

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:

DPX:	DAPPUDRAFT_52801

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MRJ:

HAZT:

EAF:	111700812 111708608

LSM:	121115276 121123040

TCF:	131883744 131892762

PPOI:

119098003 119098730 119105780

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107360064 107364172

DPTE:

113794373 113796826

DFR:	124490693 124497237

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106458888 106461056 106466120

PMEO:

129581652

CEL:	CELE_T28F2.5(ccb-1)

CBR:	CBG_11986(Cbr-ccb-1)

NAI:	NECAME_03464

BMY:	BM_BM6074(Bma-ccb-1)

LOA:	LOAG_09222

TSP:

Tsp_10785

LGI:	LOTGIDRAFT_123099

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111122806 111127322

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_135140 Smp_141660

SHX:	MS3_00001788(CACNB2_1) MS3_00002384(CACNB1)

OVI:	T265_15325

EGL:	EGR_04487 EGR_10568

NVE:	116601544 5505230

EPA:	110232233 110248878

ATEN:

116298972

ADF:	107333273 107347207

AMIL:

114966452 114970264

PDAM:

113681752 113682176

SPIS:

111322969 111330206

DGT:	114517669 114543519

XEN:

HMG:

HSY:

RES:

Reference

PMID:12042350

Authors

Colecraft HM, Alseikhan B, Takahashi SX, Chaudhuri D, Mittman S, Yegnasubramanian V, Alvania RS, Johns DC, Marban E, Yue DT

Title

Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells.

Journal

J Physiol 541:435-52 (2002)
DOI:10.1113/jphysiol.2002.018515

Sequence

[hsa:783]

LinkDB

ORTHOLOGY: K04864

Entry

K04864                      KO

Symbol

CACNB3

Name

voltage-dependent calcium channel beta-3

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04864  CACNB3; voltage-dependent calcium channel beta-3
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04864  CACNB3; voltage-dependent calcium channel beta-3
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04864  CACNB3; voltage-dependent calcium channel beta-3
   04261 Adrenergic signaling in cardiomyocytes
    K04864  CACNB3; voltage-dependent calcium channel beta-3
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04864  CACNB3; voltage-dependent calcium channel beta-3
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04864  CACNB3; voltage-dependent calcium channel beta-3
   05414 Dilated cardiomyopathy
    K04864  CACNB3; voltage-dependent calcium channel beta-3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04864  CACNB3; voltage-dependent calcium channel beta-3
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04864  CACNB3; voltage-dependent calcium channel beta-3

Other DBs

GO:

0005245

TC:	8.A.22.1.3

Genes

HSA:	784(CACNB3)

PTR:	451867(CACNB3)

PPS:	100992015(CACNB3)

GGO:	101141345(CACNB3)

PON:	100438771(CACNB3)

PPYG:

129009387(CACNB3)

NLE:	100588634(CACNB3)

HMH:	116462038(CACNB3)

SSYN:

129491140(CACNB3)

MCC:	708091(CACNB3)

MCF:	102117465(CACNB3)

MTHB:

126930167

MNI:	105492898(CACNB3)

CSAB:

103238243(CACNB3)

CATY:

105580402(CACNB3)

PANU:

101009342(CACNB3)

TGE:	112634725(CACNB3)

MLEU:

105544917(CACNB3)

RRO:	104679736(CACNB3)

RBB:	108543940(CACNB3)

TFN:	117090194(CACNB3)

PTEH:

111542053(CACNB3)

CANG:

105507647(CACNB3)

CJC:	100415618(CACNB3)

SBQ:	101040084(CACNB3)

CIMI:

108316027(CACNB3)

ANAN:

105709468(CACNB3)

CSYR:

103273461(CACNB3)

MMUR:

105867910(CACNB3)

LCAT:

123640441(CACNB3)

PCOQ:

105817570(CACNB3)

OGA:	100941047(CACNB3)

MMU:	12297(Cacnb3)

MCAL:

110310131(Cacnb3)

MPAH:

110334476(Cacnb3)

RNO:	25297(Cacnb3)

MCOC:

116079136(Cacnb3)

ANU:	117718775(Cacnb3)

MUN:	110547429(Cacnb3)

CGE:	100768080(Cacnb3)

MAUA:

101836179(Cacnb3)

PROB:

127226030(Cacnb3)

PLEU:

114708536(Cacnb3)

MORG:

121441448(Cacnb3)

MFOT:

126493782

AAMP:

119822706(Cacnb3)

NGI:	103750559(Cacnb3)

HGL:	101696342(Cacnb3)

CPOC:

100730569(Cacnb3)

CCAN:

109695485(Cacnb3)

DORD:

105987469(Cacnb3)

DSP:	122106361(Cacnb3)

PLOP:

125365324(Cacnb3)

NCAR:

124982456

MMMA:

107148590(Cacnb3)

OCU:	100009402(CACNB3)

OPI:	101528200(CACNB3)

TUP:	102502262(CACNB3)

GVR:	103588862(CACNB3)

CFA:	486563(CACNB3)

CLUD:

112678271(CACNB3)

VVP:	112921092(CACNB3)

VLG:	121480012(CACNB3)

NPO:	129517393(CACNB3)

AML:	100479948(CACNB3)

UMR:	103675445(CACNB3)

UAH:	113257670(CACNB3)

UAR:	123794793(CACNB3)

ELK:

111157805

LLV:

125106493

MPUF:

101675014(CACNB3)

MNP:	132019634(CACNB3)

MLK:	131838819(CACNB3)

NVS:	122891068(CACNB3)

ORO:	101372967(CACNB3)

EJU:	114225873(CACNB3)

ZCA:	113921962(CACNB3)

MLX:	118008900(CACNB3)

NSU:	110593647(CACNB3)

LWW:	102733139(CACNB3)

FCA:	101091635(CACNB3)

PYU:	121038645(CACNB3)

PCOO:

112867502(CACNB3)

PBG:	122472339(CACNB3)

PVIV:

125171039(CACNB3)

LRUF:

124502293

PTG:	102949738(CACNB3)

PPAD:

109249047(CACNB3)

PUC:

125919010

AJU:

106969296

HHV:	120223021(CACNB3)

BTA:	282160(CACNB3)

BOM:	102265606(CACNB3)

BIU:	109559157(CACNB3)

BBUB:

102406685(CACNB3)

BBIS:

105001460(CACNB3)

CHX:	102182201(CACNB3)

OAS:	101104978(CACNB3)

BTAX:

128048899(CACNB3)

ODA:	120858174 120861291

CCAD:

122427248(CACNB3)

MBEZ:

129536036(CACNB3)

SSC:	100524021(CACNB3)

CFR:	102519996(CACNB3)

CBAI:

105076188(CACNB3)

CDK:	105103791(CACNB3)

VPC:	102532996(CACNB3)

BACU:

103004138(CACNB3)

BMUS:

118902626(CACNB3)

LVE:	103075622(CACNB3)

OOR:	101272268(CACNB3)

DLE:	111174049(CACNB3)

PCAD:

102985520(CACNB3)

PSIU:

116760842(CACNB3)

NASI:

112394288(CACNB3)

ECB:	100051367(CACNB3)

EPZ:	103552221(CACNB3)

EAI:	106836823(CACNB3)

MYB:	102247877(CACNB3)

MYD:	102765261(CACNB3)

MMYO:

118650185(CACNB3)

MLF:	102433470(CACNB3)

MDT:	132227521(CACNB3)

PKL:	118728621(CACNB3)

EFUS:

103285249(CACNB3)

MNA:	107528234(CACNB3)

DRO:	112318438(CACNB3)

SHON:

118976461(CACNB3)

AJM:	119042185(CACNB3)

PDIC:

114512933(CACNB3)

PHAS:

123812925(CACNB3)

MMF:	118624294(CACNB3)

PPAM:

129084880(CACNB3)

HAI:	109393268(CACNB3)

RFQ:	117029070(CACNB3)

PALE:

102890340(CACNB3)

PGIG:

120618213(CACNB3)

PVP:	105297519(CACNB3)

RAY:	107514227(CACNB3)

MJV:	108383501(CACNB3)

TOD:	119247877(CACNB3)

SARA:

101558905(CACNB3)

SETR:

126022513(CACNB3)

LAV:	100653996(CACNB3)

TMU:

101349665

ETF:	101650161(CACNB3)

DNM:	101427165(CACNB3)

MDO:	100016894(CACNB3)

GAS:	123250387(CACNB3)

SHR:	100925515(CACNB3)

AFZ:

127564776

PCW:	110201498(CACNB3)

TVP:	118852090(CACNB3)

OAA:	100087409(CACNB3)

GGA:

107050029

PCOC:

116238646(CACNB3)

CJO:	107307084(CACNB3)

APLA:

113840017(CACNB3)

ACYG:

125181397(CACNB3)

CATA:

118261358(CACNB3)

AFUL:

116499912(CACNB3)

TGU:	100229808(CACNB3)

LSR:	110480389(CACNB3)

PMOA:

120499481(CACNB3)

OTC:	121334254(CACNB3)

PRUF:

121356304(CACNB3)

GFR:	102033186(CACNB3)

FAB:	101811107(CACNB3)

OMA:	130265761(CACNB3)

PHI:

102104366

PMAJ:

107198564(CACNB3)

CCAE:

111940551(CACNB3)

CBRC:

103611919(CACNB3)

ETL:	114071080(CACNB3)

ZLE:	135459171(CACNB3)

SVG:	106862687(CACNB3)

MMEA:

130584144(CACNB3)

HRT:	120747577(CACNB3)

SATI:

136372804(CACNB3)

FPG:	101916106(CACNB3)

SHAB:

115618662(CACNB3)

TALA:

116962934(CACNB3)

ACHC:

115351012(CACNB3)

HLE:	104831175(CACNB3)

AGEN:

126046315

NNI:	104019884(CACNB3)

CLV:	102092365(CACNB3)

CUCA:

104055012(CACNB3)

CVF:	104284822(CACNB3)

RTD:	128901260(CACNB3)

AROW:

112960856

NPD:	112950313(CACNB3)

DNE:	112996395(CACNB3)

ASN:	102372095(CACNB3)

AMJ:	102559082(CACNB3)

CPOO:

109324468(CACNB3)

PSS:	102449313(CACNB3)

CMY:	102942404(CACNB3)

CCAY:

125627444(CACNB3)

DCC:	119845765(CACNB3)

CPIC:

101948725(CACNB3)

TST:	117889270(CACNB3)

CABI:

116827787(CACNB3)

MRV:	120391312(CACNB3)

ACS:	100557874(cacnb3)

ASAO:

132768344(CACNB3)

PVT:	110074928(CACNB3)

SUND:

121922393(CACNB3)

PBI:	103050524(CACNB3)

PMUR:

107285719(CACNB3)

CTIG:

120302349(CACNB3)

TSR:	106551155(CACNB3) 106555908

PGUT:

117662737(CACNB3)

APRI:

131191462(CACNB3)

PTEX:

113445485(CACNB3)

NSS:	113418459(CACNB3)

VKO:	123019210(CACNB3)

PMUA:

114592963(CACNB3)

PRAF:

128405208(CACNB3)

ZVI:	118077483(CACNB3)

HCG:	128347941(CACNB3)

GJA:	107120883(CACNB3)

STOW:

125427878(CACNB3)

EMC:	129327503(CACNB3)

XLA:	373616(cacnb3.S) 378546(cacnb3.L)

XTR:	100145181(cacnb3)

NPR:

108801801

RTEM:

120929587(CACNB3)

BBUF:

120995951(CACNB3)

BGAR:

122931204(CACNB3)

MUO:	115465940(CACNB3)

GSH:	117357750(CACNB3)

DRE:	559015(cacnb3b) 565158(cacnb3a)

SRX:	107705735 107716190 107724200 107745477

SANH:

107668566 107693548 107695823 107696997

SGH:	107570227 107594466 107601341

CCAR:

109051973 109072227 109076719

CAUA:

113041067 113065454 113070524 113092998

CGIB:

127944565 127944786 128011118 128011305

PTET:

122328628(cacnb3a) 122329310(cacnb3b)

LROH:

127154640(cacnb3a) 127154868(cacnb3b)

OMC:	131531922(cacnb3b) 131532216(cacnb3a)

PPRM:

120463783(cacnb3b) 120487998 120488249

RKG:	130070787(cacnb3a) 130073197(cacnb3b)

MAMB:

125259658(cacnb3a) 125260718(cacnb3b)

CIDE:

127504675 127505207

CERY:

137008884(cacnb3a) 137008938(cacnb3b)

MASI:

127419038 127419234 127419613 127419951

TROS:

130545022(cacnb3a) 130545435(cacnb3b)

TDW:	130408762(cacnb3a) 130409686(cacnb3b)

MANU:

129430367(cacnb3a) 129431141(cacnb3b)

IPU:	108275626(cacnb3b)

IFU:	128619655(cacnb3b)

PHYP:

113530644

TFD:	113658104(cacnb3b)

TVC:	132862488(cacnb3b)

TRN:	134333244(cacnb3a) 134333842(cacnb3b)

AMEX:

103035950(cacnb3a) 103036708(cacnb3b)

CMAO:

118822305(cacnb3b) 118823080(cacnb3a)

EEE:	113568537 113583119(cacnb3)

CHAR:

105897273(cacnb3b) 105912747(cacnb3a)

TRU:	101064390 101071111(cacnb3) 115249151

TFS:	130529874 130530162(cacnb3b)

TNG:	GSTEN00028127G001

LCO:	104919644(cacnb3) 104933409

NCC:

104967530

TBEN:

117479567(cacnb3a) 117494285(cacnb3b)

CGOB:

115010642 115010710

PGEO:

117449029 117450143(cacnb3b)

GACU:

117542071(cacnb3b) 117542981

EMAC:

134864681(cacnb3a) 134871911(cacnb3b)

ELY:	117258457(cacnb3b) 117258595

EFO:	125891519(cacnb3a) 125892197(cacnb3b)

PLEP:

121946850(cacnb3b) 121947478(cacnb3a)

SLUC:

116039348(cacnb3b) 116062174(cacnb3a)

ECRA:

117947783(cacnb3b) 117947945

ESP:	116692310 116692510

PFLV:

114558749

GAT:	120829111(cacnb3b) 120829552(cacnb3a)

PPUG:

119222272(cacnb3b) 119223642(cacnb3a)

AFB:	129099578(cacnb3b) 129099976

CLUM:

117733176 117734117

PSWI:

130199789(cacnb3b) 130200161

MSAM:

119905280 119905505(cacnb3b)

SCHU:

122883421(cacnb3b) 122883621(cacnb3a)

CUD:	121516900(cacnb3b) 121517739(cacnb3a)

ALAT:

119022797(cacnb3a) 119023419(cacnb3b)

ASTR:

137605750(cacnb3a) 137606645(cacnb3b)

MZE:	101472360 101483550(cacnb3)

ONL:	100704754(cacnb3) 100705687

OAU:	116310890(cacnb3a) 116325841(cacnb3b)

OLA:	101157698 101164307

OML:	112159101(cacnb3a) 112159672(cacnb3b)

CSAI:

133456803(cacnb3a) 133457217(cacnb3b)

XMA:	102221379 102232874

XCO:	114148398 114161884(cacnb3)

XHE:	116726310(cacnb3) 116726859

PRET:

103467315 103467623

PFOR:

103141209 103147812(cacnb3)

PLAI:

106950868 106961456(cacnb3)

PMEI:

106906070 106914965

GAF:	122837569(cacnb3b) 122839084(cacnb3a)

PPRL:

129370274(cacnb3a) 129372437(cacnb3b)

CVG:	107090276 107095154

CTUL:

119774128 119782259(cacnb3b)

GMU:	124874440(cacnb3a) 124874636(cacnb3b)

NFU:	107390846 107391217

KMR:

108232107

ALIM:

106522508 106525262

NWH:	119417281(cacnb3b) 119417523(cacnb3a)

AOCE:

111567032 111576514

MCEP:

125007855(cacnb3a) 125010521(cacnb3b)

CSEM:

103384591 103385411(cacnb3)

POV:	109630938 109635185

SSEN:

122777048(cacnb3a) 122777787(cacnb3b)

HHIP:

117764057(cacnb3a) 117764774(cacnb3b)

HSP:	118110502 118111577(cacnb3b)

PPLT:

128442500 128442531(cacnb3b)

SMAU:

118316260 118316418(cacnb3b)

LCF:	108876503(cacnb3b) 108900206(cacnb3a)

SDU:	111217370 111218998

SLAL:

111670810 111671542

XGL:	120804424(cacnb3a) 120804459(cacnb3b)

HCQ:	109528553 109528742

SSCV:

125989193 125989325

SBIA:

133493907 133495488

PEE:	133409517(cacnb3a) 133414197

PTAO:

133477431 133487974(cacnb3a)

BPEC:

110164617 110164764

MALB:

109966068 109971856

BSPL:

114858622(cacnb3a) 114859123(cacnb3b)

SJO:	128356754(cacnb3b) 128356919

SASA:

106571945

STRU:

115165461 115166183 115167807

OTW:	112215796(cacnb3a)

OMY:	110491935 110531166 110532726

OGO:	124017947 124031730(cacnb3a) 124045709 124046120

ONE:	115101632 115102672 115125792 115131918

OKI:	109869667 109908510

OKE:	118360140 118360441(cacnb3a) 118372730

SALP:

111966240(cacnb3)

SNH:	120058983(cacnb3a) 120060958(cacnb3b)

CCLU:

121537862(cacnb3b) 121538101(cacnb3a) 121545890 121546445

ELS:

105026314

SFM:	108918540(cacnb3) 108939151

PKI:	111837474(cacnb3)

AANG:

118208663(cacnb3b) 118211196

LOC:	102698540(cacnb3)

PSPA:

121309021(cacnb3a)

ARUT:

117400863 117966893

PSEX:

120524821(cacnb3a)

LCM:	102358572(CACNB3)

CMK:

103173178

DCI:

103504864

» show all

Reference

PMID:22187436

Authors

Li L, Cao XH, Chen SR, Han HD, Lopez-Berestein G, Sood AK, Pan HL

Title

Up-regulation of Cavbeta3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain.

Journal

J Biol Chem 287:6002-13 (2012)
DOI:10.1074/jbc.M111.310110

Sequence

[rno:25297]

LinkDB

ORTHOLOGY: K04865

Entry

K04865                      KO

Symbol

CACNB4

Name

voltage-dependent calcium channel beta-4

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00749

Episodic ataxias

H00808

Idiopathic generalized epilepsies

H02217

Juvenile myoclonic epilepsy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04865  CACNB4; voltage-dependent calcium channel beta-4
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04865  CACNB4; voltage-dependent calcium channel beta-4
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04865  CACNB4; voltage-dependent calcium channel beta-4
   04261 Adrenergic signaling in cardiomyocytes
    K04865  CACNB4; voltage-dependent calcium channel beta-4
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04865  CACNB4; voltage-dependent calcium channel beta-4
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04865  CACNB4; voltage-dependent calcium channel beta-4
   05414 Dilated cardiomyopathy
    K04865  CACNB4; voltage-dependent calcium channel beta-4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04865  CACNB4; voltage-dependent calcium channel beta-4
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04865  CACNB4; voltage-dependent calcium channel beta-4

Other DBs

GO:

0005245

TC:	8.A.22.1.4

Genes

HSA:	785(CACNB4)

PTR:	459660(CACNB4)

PPS:	100976785(CACNB4)

GGO:	101137663(CACNB4)

PON:	100444432(CACNB4)

PPYG:

129031699(CACNB4)

NLE:	100597041(CACNB4)

HMH:	116810802(CACNB4)

SSYN:

129489479(CACNB4)

MCC:	695172(CACNB4)

MCF:	102116137(CACNB4)

MTHB:

126933022

MNI:	105492663(CACNB4)

CSAB:

103217090(CACNB4)

CATY:

105575977(CACNB4)

PANU:

101021665(CACNB4)

TGE:	112636036(CACNB4)

MLEU:

105545088(CACNB4)

RRO:	104669805(CACNB4)

RBB:	108525018(CACNB4)

TFN:	117095001(CACNB4)

PTEH:

111546115(CACNB4)

CANG:

105512569(CACNB4)

CJC:	100393056(CACNB4)

SBQ:	101031728(CACNB4)

CIMI:

108300436(CACNB4)

ANAN:

105720496(CACNB4)

CSYR:

103273638(CACNB4)

MMUR:

105879602(CACNB4)

LCAT:

123643468(CACNB4)

PCOQ:

105822257(CACNB4)

OGA:	100948836(CACNB4)

MMU:	12298(Cacnb4)

MCAL:

110308006(Cacnb4)

MPAH:

110317586(Cacnb4)

RNO:	58942(Cacnb4)

MCOC:

116090169(Cacnb4)

ANU:	117703087(Cacnb4)

MUN:	110563773(Cacnb4)

CGE:	100765888(Cacnb4)

MAUA:

101844274(Cacnb4)

PROB:

127222517(Cacnb4)

PLEU:

114698446(Cacnb4)

MORG:

121433143(Cacnb4)

MFOT:

126500247

AAMP:

119818715(Cacnb4)

NGI:	103738122(Cacnb4)

HGL:	101723713(Cacnb4)

CPOC:

100723776(Cacnb4)

CCAN:

109695158(Cacnb4)

DORD:

105993857(Cacnb4)

DSP:	122110846(Cacnb4)

PLOP:

125350665(Cacnb4)

NCAR:

124979835

MMMA:

107136859(Cacnb4)

OCU:

100344224

OPI:	101534179(CACNB4)

TUP:	102474154(CACNB4)

GVR:	103585423(CACNB4)

CFA:	609361(CACNB4)

CLUD:

112673312(CACNB4)

VVP:	112926879(CACNB4)

VLG:	121482149(CACNB4)

NPO:	129495608 129514650

AML:	100464104(CACNB4)

UMR:	103659848(CACNB4)

UAH:	113250882(CACNB4)

UAR:	123782064(CACNB4)

ELK:

111141476

LLV:

125095828

MPUF:

101673997(CACNB4)

MNP:	132013746(CACNB4)

MLK:	131827214(CACNB4)

NVS:	122902498(CACNB4)

ORO:	101374377(CACNB4)

EJU:	114216479(CACNB4)

ZCA:	113920171(CACNB4)

MLX:	118012447(CACNB4)

NSU:	110591893(CACNB4)

LWW:	102741806(CACNB4)

FCA:	101101576(CACNB4)

PYU:	121030560(CACNB4)

PCOO:

112848734(CACNB4)

PBG:	122481337(CACNB4)

PVIV:

125171985(CACNB4)

LRUF:

124515448

PTG:	102953668(CACNB4)

PPAD:

109271149(CACNB4)

PUC:

125911409

AJU:

106976065

HHV:	120225730(CACNB4)

BTA:	282161(CACNB4)

BOM:	102265990(CACNB4)

BIU:	109567608(CACNB4)

BBUB:

102409578(CACNB4)

BBIS:

104988624(CACNB4)

CHX:	102179332(CACNB4)

OAS:	101117907(CACNB4)

BTAX:

128064089(CACNB4)

ODA:	120854796(CACNB4)

CCAD:

122453844(CACNB4)

MBEZ:

129538305(CACNB4)

SSC:	396585(CACNB4)

CFR:	102518736(CACNB4)

CBAI:

105079160(CACNB4)

CDK:	105093727(CACNB4)

VPC:	102529782(CACNB4)

BACU:

103013367(CACNB4)

BMUS:

118897863(CACNB4)

LVE:	103089902(CACNB4)

OOR:	101269896(CACNB4)

DLE:	111172760(CACNB4)

PCAD:

102977440(CACNB4)

PSIU:

116757004(CACNB4)

NASI:

112393604(CACNB4)

ECB:	100057916(CACNB4)

EPZ:	103558127(CACNB4)

EAI:	106824678(CACNB4)

MYB:	102261332(CACNB4)

MYD:	102752339(CACNB4)

MMYO:

118661875(CACNB4)

MLF:	102418251(CACNB4)

MDT:	132238639(CACNB4)

PKL:	118709669(CACNB4)

EFUS:

103283409(CACNB4)

MNA:	107531651(CACNB4)

DRO:	112312991(CACNB4)

SHON:

118974423(CACNB4)

AJM:	119038775(CACNB4)

PDIC:

114494364(CACNB4)

PHAS:

123807622(CACNB4)

MMF:	118625398(CACNB4)

PPAM:

129061885(CACNB4)

HAI:	109384861(CACNB4)

RFQ:	117025859(CACNB4)

PALE:

102896224(CACNB4)

PGIG:

120596875(CACNB4)

PVP:	105292163(CACNB4)

RAY:	107513916(CACNB4)

MJV:	108406382(CACNB4)

TOD:	119255835(CACNB4)

SARA:

101538572(CACNB4)

SETR:

126008765(CACNB4)

LAV:	100656938(CACNB4)

TMU:

101351408

ETF:	101662240(CACNB4)

DNM:	101435286(CACNB4)

MDO:	100019993(CACNB4)

GAS:	123242259(CACNB4)

SHR:	100924116(CACNB4)

AFZ:

127554658

PCW:	110196898(CACNB4)

TVP:	118838629(CACNB4)

OAA:	100080287(CACNB4)

GGA:	374259(CACNB4)

PCOC:

116227460(CACNB4)

MGP:	100544561(CACNB4)

CJO:	107316971(CACNB4)

TPAI:

128076880(CACNB4)

LMUT:

125696956(CACNB4)

NMEL:

110399249(CACNB4)

APLA:

101798353(CACNB4)

ACYG:

106046874(CACNB4)

CATA:

118257760(CACNB4)

AFUL:

116490515(CACNB4)

TGU:	100225217(CACNB4)

LSR:	110473132(CACNB4)

SCAN:

103814617(CACNB4)

PMOA:

120497318(CACNB4)

OTC:	121337807(CACNB4)

PRUF:

121353455(CACNB4)

GFR:	102035820(CACNB4)

FAB:	101815605(CACNB4)

OMA:	130255325(CACNB4)

PHI:	102111016(CACNB4)

PMAJ:

107207455(CACNB4)

CCAE:

111932372(CACNB4)

CCW:	104694105(CACNB4)

CBRC:

103616784(CACNB4)

ETL:	114067462(CACNB4)

ZAB:	102062449(CACNB4)

ZLE:	135450621(CACNB4)

ACHL:

103799219

SVG:	106863709(CACNB4)

MMEA:

130585841(CACNB4)

HRT:	120754936(CACNB4)

SATI:

136363744(CACNB4)

FPG:	101918928(CACNB4)

FCH:	102054191(CACNB4)

CCRI:

104164251

NNT:

104413858

SHAB:

115607847(CACNB4)

ACUN:

113481993(CACNB4)

TALA:

104358353(CACNB4)

ACHC:

115342885(CACNB4)

HALD:

104316713

HLE:	104829054(CACNB4)

AGEN:

126040721

GCL:

127018265

CSTI:

104553801(CACNB4)

LDI:

104352235

MNB:	103780040(CACNB4)

DPUB:

104308270(CACNB4)

EGZ:	104130401(CACNB4)

NNI:	104012362(CACNB4)

PCRI:

104031437(CACNB4)

PCAO:

104041853

PADL:

103912670(CACNB4)

AFOR:

103893884(CACNB4)

FGA:

104074730

GSTE:

104255451

CLV:	102085477(CACNB4)

MUI:	104539809(CACNB4)

PGUU:

104469126

PLET:

104618560

CMAC:

104478541

CUCA:

104056204(CACNB4)

TEO:

104374666

BREG:

104635940

OHA:	104331757(CACNB4)

CPEA:

104392820(CACNB4)

CVF:	104285567(CACNB4)

RTD:	128912430(CACNB4)

AAM:	106482299(CACNB4)

AROW:

112962267(CACNB4)

NPD:	112946348(CACNB4)

TGT:	104569151(CACNB4)

DNE:	112984858(CACNB4)

SCAM:

104138745(CACNB4)

ASN:	102368360(CACNB4)

AMJ:	106736635(CACNB4)

CPOO:

109323099(CACNB4)

GGN:	109301310(CACNB4)

PSS:	102450169(CACNB4)

CMY:	102932640(CACNB4)

CCAY:

125644948(CACNB4)

DCC:	119863607(CACNB4)

CPIC:

101941206(CACNB4)

TST:	117884730(CACNB4)

CABI:

116826774(CACNB4)

MRV:	120374744(CACNB4)

ACS:	100337606(cacnb4)

ASAO:

132775750(CACNB4)

PVT:	110080837(CACNB4)

SUND:

121936727(CACNB4)

PBI:	103053209(CACNB4)

PMUR:

107286075

CTIG:

120304625(CACNB4)

TSR:	106550522(CACNB4)

PGUT:

117670118(CACNB4)

APRI:

131203006(CACNB4)

PTEX:

113434160(CACNB4)

NSS:	113420241 113420250

VKO:	123017266(CACNB4)

PMUA:

114605085(CACNB4)

PRAF:

128422665(CACNB4)

ZVI:	118092935(CACNB4)

HCG:	128338973(CACNB4)

GJA:	107125599(CACNB4)

STOW:

125425798(CACNB4)

EMC:	129324824(CACNB4)

XLA:	108701326 108702958

XTR:	100216182(cacnb4)

NPR:	108784717(CACNB4)

RTEM:

120944109(CACNB4)

BBUF:

121008665(CACNB4)

BGAR:

122944833(CACNB4)

MUO:	115473972(CACNB4)

GSH:	117361405(CACNB4)

DRE:	562422(cacnb4a) 678560(cacnb4b)

SRX:	107705621 107714393 107741900 107748538

SANH:

107660102 107660636 107673733 107688838

SGH:	107555918(cacnb4) 107566792 107596082 107596307

CCAR:

109056079 109064838 109071291 109079342

CAUA:

113050765 113053056 113093884 113108401

CGIB:

127960198 127964447 128015412 128020013

PTET:

122341544 122347603(cacnb4b) 122352078(cacnb4a)

LROH:

127166856(cacnb4b) 127171005(cacnb4a)

OMC:	131542555(cacnb4b) 131547319(cacnb4a)

PPRM:

120461475(cacnb4a) 120476804(cacnb4b)

RKG:	130096613(cacnb4a) 130101221(cacnb4b)

MAMB:

125270203(cacnb4a) 125274289(cacnb4b)

CIDE:

127514640 127519101

CERY:

137010651(cacnb4b) 137035408(cacnb4a)

MASI:

127446618 127446874 127448501 127449237

TROS:

130555612(cacnb4a) 130557129(cacnb4b)

TDW:	130424532(cacnb4b) 130427441(cacnb4a)

MANU:

129450721(cacnb4b) 129451918(cacnb4a)

IPU:	108266240(cacnb4a) 108272385(cacnb4b)

IFU:	128608652(cacnb4a) 128615813(cacnb4b)

PHYP:

113525997 113538467

SMEO:

124382810(cacnb4a) 124390797(cacnb4b)

TFD:	113634595(cacnb4b) 113654126(cacnb4a)

TVC:	132844803(cacnb4b) 132850114(cacnb4a)

TRN:	134317021(cacnb4b) 134324684(cacnb4a)

AMEX:

103031296(cacnb4a) 103041078(cacnb4b)

CMAO:

118807752(cacnb4b) 118809457(cacnb4a)

EEE:	113574052 113591692

CHAR:

105889629(cacnb4b) 122131761(cacnb4a)

TRU:	101065065(cacnb4.1) 101070730(cacnb4)

TFS:	130521794(cacnb4a) 130522267

TNG:	GSTEN00027037G001 GSTEN00029194G001

LCO:	104918232(cacnb4) 104931468

NCC:	104962611(cacnb4)

TBEN:

117496098(cacnb4a) 117499242

CGOB:

115019250 115026075(cacnb4)

PGEO:

117460267 117466638(cacnb4a)

GACU:

117546902 117549650(cacnb4a)

EMAC:

134860964 134867402(cacnb4a)

ELY:	117251525(cacnb4a) 117255209

EFO:	125885207 125899935(cacnb4a)

PLEP:

121949240(cacnb4a) 121962819

SLUC:

116044723 116066557(cacnb4a)

ECRA:

117939616 117952805(cacnb4a)

ESP:	116673752 116697891

PFLV:

114550852 114564014(cacnb4)

GAT:	100192309(cacnb4.1) 120834172(cacnb4a)

PPUG:

119211730 119228737(cacnb4a)

AFB:	129105115(cacnb4a) 129111573

CLUM:

117745826 117750246(cacnb4a)

PSWI:

130204599

MSAM:

119903240 119904440(cacnb4a)

SCHU:

122872190 122885103(cacnb4a)

CUD:	121506207 121523116(cacnb4a)

ALAT:

119015381 119026369(cacnb4a)

ASTR:

137591319(cacnb4b) 137604790(cacnb4a)

MZE:	101466725 101481806(cacnb4)

ONL:	100697371 100697725(cacnb4)

OAU:	116314771(cacnb4a) 116316921(cacnb2b) 116327191

OLA:	100192310(cacnb4.1) 101158981(cacnb4) 101163462

OML:	112136806 112154990(cacnb4a)

CSAI:

133425425 133445740(cacnb4a)

XMA:	102233017 102234485(cacnb4)

XCO:	114138204 114147959

XHE:	116716039 116722992(cacnb4)

PRET:

103475101 103478450(cacnb4)

PFOR:

103134832(cacnb4) 103151962

PLAI:

106934812(cacnb4) 106938228

PMEI:

106925852(cacnb4) 106926546

GAF:	122826866 122840435(cacnb4a)

PPRL:

129355400 129361286(cacnb4a)

CVG:	107092231 107098701(cacnb4)

CTUL:

119778485(cacnb4a) 119792313

GMU:	124861210 124871371(cacnb4a)

NFU:	107380913 107389651(cacnb4)

KMR:	108238841(cacnb4a) 108244163

ALIM:

106529643 106536644

NWH:

119428723

AOCE:

111564146(cacnb4) 111586012

MCEP:

125000954 125017902(cacnb4a)

CSEM:

103389337 103391617(cacnb4)

POV:	109638020(cacnb4) 109640071

SSEN:

122765064 122765078(cacnb4a)

HHIP:

117754995(cacnb4a) 117777765

HSP:	118103622 118120030(cacnb4a)

PPLT:

128430998 128456210(cacnb4a)

SMAU:

118282497(cacnb4a) 118300716

LCF:	108892915 108897092(cacnb4a)

SDU:	111218646(cacnb4) 111239914

SLAL:

111657545(cacnb4) 111665294

XGL:	120787369 120798376 120801781(cacnb4a)

HCQ:	109520929 109521895

SSCV:

125973909 125988909

SBIA:

133492612 133512475(cacnb4a)

PEE:	133411085(cacnb4a) 133411109

PTAO:

133486884(cacnb4a) 133490252

BPEC:

110156629(cacnb4) 110163257

MALB:

109960559 109974011(cacnb4)

BSPL:

114846903(cacnb4a) 114851089

SJO:	128354560 128368451(cacnb4a)

SASA:

106575807 106582346 106586393

STRU:

115155601 115160934 115179349 115196485

OTW:	112225596 112238503 112253618

OMY:	110501812 110520263 110527258 110527259

OGO:	124011405 124027933 124043986 124048060

ONE:	115110736 115130141

OKI:	109868051 109871003 109876447 109876649

OKE:	118366917 118379658 118386349

SALP:

111959873 111977107

SNH:	120050549 120050568 120057914 120063766

CCLU:

121537025(cacnb4a) 121555007 121582941

ELS:	105016118(cacnb4) 105023164

SFM:	108930040(cacnb4) 108936607

PKI:	111851740(cacnb4)

AANG:

118214156 118222173(cacnb4a)

LOC:	102689881(cacnb4)

PSPA:

121322389 121323228

ARUT:

117410861 117426960

PSEX:

120530715(cacnb4a)

LCM:	102367248(CACNB4)

CMK:	103180441(cacnb4a)

RTP:	109915118(cacnb4a)

CPLA:

122551757(cacnb4a)

HOC:	132817396(cacnb4a)

LERI:

129699085(cacnb4a)

LPOL:

106458736 106474022

ATEN:

116302860

TAD:	TRIADDRAFT_22195

» show all

Reference

PMID:22892567

Authors

Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M

Title

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.

Journal

EMBO J 31:3730-44 (2012)
DOI:10.1038/emboj.2012.226

Sequence

[hsa:785]

LinkDB

ORTHOLOGY: K04858

Entry

K04858                      KO

Symbol

CACNA2D1

Name

voltage-dependent calcium channel alpha-2/delta-1

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00606

Early infantile epileptic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
   04261 Adrenergic signaling in cardiomyocytes
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
   05414 Dilated cardiomyopathy
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1

Other DBs

GO:

0005245

TC:

8.A.18.1

Genes

HSA:	781(CACNA2D1)

PTR:	463504(CACNA2D1)

PPS:	100982794(CACNA2D1)

GGO:	101128490(CACNA2D1)

PON:	100171724(CACNA2D1)

PPYG:

129040537(CACNA2D1)

NLE:	100595072(CACNA2D1)

HMH:	116814159(CACNA2D1)

SSYN:

129484809(CACNA2D1)

MCC:	708215(CACNA2D1)

MCF:	102131750(CACNA2D1)

MTHB:

126949899

MNI:	105475402(CACNA2D1)

CSAB:

103226639(CACNA2D1)

CATY:

105583235(CACNA2D1)

PANU:

101018169(CACNA2D1)

TGE:	112621007(CACNA2D1)

MLEU:

105543929(CACNA2D1)

RRO:	104681577(CACNA2D1)

RBB:	108536908(CACNA2D1)

TFN:	117072561(CACNA2D1)

PTEH:

111552459(CACNA2D1)

CANG:

105501674(CACNA2D1)

CJC:	100385605(CACNA2D1)

SBQ:	101053043(CACNA2D1)

CIMI:

108300338(CACNA2D1)

ANAN:

105726650(CACNA2D1)

CSYR:

103249923(CACNA2D1)

MMUR:

105879323(CACNA2D1)

LCAT:

123647164(CACNA2D1)

OGA:	100963985(CACNA2D1)

MMU:	12293(Cacna2d1)

MCAL:

110295349(Cacna2d1)

MPAH:

110316372(Cacna2d1)

RNO:	25399(Cacna2d1)

MCOC:

116097487(Cacna2d1)

ANU:	117720397(Cacna2d1)

MUN:	110541459(Cacna2d1)

CGE:	100764769(Cacna2d1)

MAUA:

101835530(Cacna2d1)

PROB:

127214540(Cacna2d1) 127218679

PLEU:

114687339(Cacna2d1)

MORG:

121434621 121459135

MFOT:

126500114

AAMP:

119803844(Cacna2d1)

NGI:	103730725(Cacna2d1)

HGL:	101708369(Cacna2d1)

CPOC:

100728887(Cacna2d1)

CCAN:

109681780(Cacna2d1)

DORD:

105992916(Cacna2d1)

DSP:	122111799(Cacna2d1)

PLOP:

125346954(Cacna2d1)

NCAR:

124990321

MMMA:

107144442(Cacna2d1)

OCU:	100009105(CACNA2D1)

OPI:	101516203(CACNA2D1)

TUP:	102482417(CACNA2D1)

GVR:	103586524(CACNA2D1)

CFA:	610342(CACNA2D1)

CLUD:

112661473(CACNA2D1)

VVP:	112925398(CACNA2D1)

VLG:	121471833(CACNA2D1)

NPO:	129494126(CACNA2D1)

AML:	100463812(CACNA2D1)

UMR:	103658778(CACNA2D1)

UAH:	113259255(CACNA2D1)

UAR:	123789347(CACNA2D1)

ELK:

111155265

LLV:

125080441

MPUF:

101678500(CACNA2D1)

MNP:	132015988(CACNA2D1)

MLK:	131829312(CACNA2D1)

NVS:	122904763(CACNA2D1)

ORO:	101373490(CACNA2D1)

EJU:	114220710(CACNA2D1)

ZCA:	113911321(CACNA2D1)

MLX:	118020687(CACNA2D1)

NSU:	110580141(CACNA2D1)

LWW:	102741417(CACNA2D1)

FCA:	101099450(CACNA2D1)

PYU:	121028792(CACNA2D1)

PCOO:

112866861(CACNA2D1)

PBG:	122487824(CACNA2D1)

PVIV:

125160370(CACNA2D1)

LRUF:

124524101

PTG:	102951633(CACNA2D1)

PPAD:

109268153(CACNA2D1)

PUC:

125929852

AJU:

106975662

HHV:	120221165(CACNA2D1)

BTA:	282608(CACNA2D1)

BOM:	102268507(CACNA2D1)

BIU:	109557331(CACNA2D1)

BBUB:

102406537(CACNA2D1)

BBIS:

104994517(CACNA2D1)

CHX:	102183035(CACNA2D1)

OAS:	101123550(CACNA2D1)

BTAX:

128046666(CACNA2D1)

ODA:	120878115(CACNA2D1)

CCAD:

122438248(CACNA2D1)

MBEZ:

129552334(CACNA2D1)

SSC:	397377(CACNA2D1)

CFR:	102520107(CACNA2D1)

CBAI:

105062378(CACNA2D1)

CDK:	105087345(CACNA2D1)

VPC:	102532132(CACNA2D1)

BACU:

103020121(CACNA2D1)

BMUS:

118900675(CACNA2D1)

LVE:	103082365(CACNA2D1)

OOR:	101273913(CACNA2D1)

DLE:	111164625(CACNA2D1)

PCAD:

102988187(CACNA2D1)

PSIU:

116759402(CACNA2D1)

NASI:

112414506

ECB:	100057533(CACNA2D1)

EPZ:	103560846(CACNA2D1)

EAI:	106840179(CACNA2D1)

MYB:	102238945(CACNA2D1)

MYD:	102774068(CACNA2D1)

MMYO:

118666272(CACNA2D1)

MLF:	102440990(CACNA2D1)

MDT:	132242889(CACNA2D1)

PKL:	118714358(CACNA2D1)

EFUS:

103293241(CACNA2D1)

MNA:	107527170(CACNA2D1)

DRO:	112303467(CACNA2D1)

SHON:

119000986(CACNA2D1)

AJM:	119044939(CACNA2D1)

PDIC:

114507533(CACNA2D1)

PHAS:

123811367(CACNA2D1)

MMF:	118620125(CACNA2D1)

PPAM:

129063313(CACNA2D1)

HAI:	109392343(CACNA2D1)

RFQ:	117012429(CACNA2D1)

PALE:

102888058(CACNA2D1)

PGIG:

120591750(CACNA2D1)

PVP:

105295536

RAY:	107501281(CACNA2D1)

MJV:	108409008(CACNA2D1)

TOD:	119250335(CACNA2D1)

SARA:

101544756(CACNA2D1)

SETR:

126013608(CACNA2D1)

LAV:	100676022(CACNA2D1)

TMU:

101345222

ETF:	101641825(CACNA2D1)

DNM:	101426221(CACNA2D1)

MDO:	100012746(CACNA2D1)

GAS:	123249992(CACNA2D1)

SHR:	100915174(CACNA2D1)

AFZ:

127538102

PCW:	110206948(CACNA2D1)

TVP:	118850038(CACNA2D1)

OAA:	100074856(CACNA2D1)

GGA:	768444(CACNA2D1)

PCOC:

116227844(CACNA2D1)

CJO:	107321641(CACNA2D1)

TPAI:

128079548(CACNA2D1)

LMUT:

125687995(CACNA2D1)

NMEL:

110392308(CACNA2D1)

APLA:

101793350(CACNA2D1)

ACYG:

106035544(CACNA2D1)

CATA:

118249509(CACNA2D1)

AFUL:

116490704(CACNA2D1)

TGU:	100227443(CACNA2D1)

LSR:	110477395(CACNA2D1)

SCAN:

103813738(CACNA2D1)

PMOA:

120509307(CACNA2D1)

OTC:	121336290(CACNA2D1)

PRUF:

121357357(CACNA2D1)

GFR:	102042376(CACNA2D1)

FAB:	101820977(CACNA2D1)

OMA:	130265610(CACNA2D1)

PHI:	102112187(CACNA2D1)

PMAJ:

107204625(CACNA2D1)

CCAE:

111923300(CACNA2D1)

CCW:	104686893(CACNA2D1)

CBRC:

103612024(CACNA2D1)

ETL:	114058725(CACNA2D1)

ZAB:	102068889(CACNA2D1)

ZLE:	135442769(CACNA2D1)

SVG:	106857396(CACNA2D1)

MMEA:

130579834(CACNA2D1)

HRT:	120752385(CACNA2D1)

FPG:	101917007(CACNA2D1)

FCH:	102059307(CACNA2D1)

CCRI:

104158630(CACNA2D1)

NNT:	104402726(CACNA2D1)

SHAB:

115605351(CACNA2D1)

ACUN:

113487405(CACNA2D1)

TALA:

104363201(CACNA2D1)

ACHC:

115341249(CACNA2D1)

HALD:

104321678(CACNA2D1)

HLE:	104840178(CACNA2D1)

AGEN:

126044352

GCL:

127014860

CSTI:

104562208(CACNA2D1)

DPUB:

104299801(CACNA2D1)

BRHI:

104492037(CACNA2D1)

EGZ:	104132378(CACNA2D1)

NNI:	104010753(CACNA2D1)

PCAO:

104044803(CACNA2D1)

PADL:

103920600(CACNA2D1)

AFOR:

103904168(CACNA2D1)

FGA:	104079504(CACNA2D1)

CLV:	102088083(CACNA2D1)

MUI:

104548701

PGUU:

104467336(CACNA2D1)

CMAC:

104486589(CACNA2D1)

CUCA:

104066037(CACNA2D1)

TEO:	104379136(CACNA2D1)

OHA:	104337640(CACNA2D1)

ACAR:

104520442(CACNA2D1)

CPEA:

104392408(CACNA2D1)

CVF:	104284579(CACNA2D1)

RTD:	128907306(CACNA2D1)

AROW:

112967579(CACNA2D1)

NPD:	112958375(CACNA2D1)

TGT:	104574729(CACNA2D1)

DNE:	112980305(CACNA2D1)

SCAM:

104144708(CACNA2D1)

ASN:	102386090(CACNA2D1)

AMJ:	102565821(CACNA2D1)

CPOO:

109315771(CACNA2D1)

GGN:	109292184(CACNA2D1)

PSS:	102450076(CACNA2D1)

CMY:	102938285(CACNA2D1)

CCAY:

125630484(CACNA2D1)

DCC:	119841581(CACNA2D1)

CPIC:

101946496(CACNA2D1)

TST:	117874908(CACNA2D1)

CABI:

116836200(CACNA2D1)

MRV:	120394404(CACNA2D1)

ACS:	100566428(cacna2d1)

ASAO:

132776532(CACNA2D1)

PVT:	110077205(CACNA2D1)

SUND:

121930397(CACNA2D1)

PBI:	103064448(CACNA2D1)

CTIG:

120312564(CACNA2D1)

PGUT:

117675801

APRI:

131201691(CACNA2D1)

PTEX:

113436564(CACNA2D1)

NSS:	113412330(CACNA2D1)

VKO:	123020042(CACNA2D1)

PMUA:

114606019(CACNA2D1)

PRAF:

128422826(CACNA2D1)

ZVI:	118090918(CACNA2D1)

HCG:	128326240(CACNA2D1)

GJA:	107124567(CACNA2D1)

STOW:

125435401(CACNA2D1)

EMC:	129336073(CACNA2D1)

XLA:	108711204(cacna2d1.L) 108713061(cacna2d1.S)

XTR:	100036724(cacna2d1)

NPR:	108792727(CACNA2D1)

RTEM:

120931732(CACNA2D1)

BBUF:

120983036(CACNA2D1)

BGAR:

122927843(CACNA2D1)

MUO:	115479265(CACNA2D1)

GSH:	117366914(CACNA2D1)

DRE:	101882457 561434(cacna2d1a)

SRX:	107723934 107732991 107738419 107738810

SANH:

107672590 107673139 107695910 107699066

SGH:	107559841 107563411(cacna2d1) 107590440

CCAR:

109080570

CAUA:

113048112 113062550 113073053 113079824 113118203

CGIB:

127934749 127956800 127974291 127977265

PTET:

122343507(cacna2d1a) 122363109

LROH:

127163798(cacna2d1a) 127180851

OMC:	131524152 131538580(cacna2d1a)

PPRM:

120462007 120476968(cacna2d1a)

RKG:	130072221(cacna2d1a) 130094860

MAMB:

125246166(cacna2d1a) 125253992

CIDE:

127500200 127510912

CERY:

137022919 137024487(cacna2d1a)

MASI:

127417060 127434833 127436773 127455820

TROS:

130547752(cacna2d1a) 130562522

TDW:	130420600(cacna2d1a) 130435603

MANU:

129418742 129431727(cacna2d1a)

IPU:

108264659

IFU:

128606937

PHYP:

113534270(cacna2d1)

SMEO:

124395491

TFD:

113652492

TVC:

132851376

TRN:	134313171(cacna2d1a) 134323335

AMEX:

103027187(cacna2d1a) 103044147

CMAO:

118812078(cacna2d1a) 118817770

EEE:	113577182 113588287

CHAR:

105889635(cacna2d1a) 105910328

TRU:	101064543(cacna2d1) 101079089

TFS:	130518961(cacna2d1a) 130535708

TNG:	GSTEN00020826G001 GSTEN00035534G001

LCO:	104918121(cacna2d1) 104918796

NCC:	104952157 104958231

TBEN:

117484974 117491237

CGOB:

115009736(cacna2d1) 115028087

PGEO:

117448686 117468436

GACU:

117537323 117545743

EMAC:

134879173(cacna2d1a) 134883824

ELY:	117249651(cacna2d1a) 117262199

EFO:	125882507(cacna2d1a) 125887227

PLEP:

121950340 121961115(cacna2d1a)

SLUC:

116045663 116060044(cacna2d1a)

ECRA:

117938675(cacna2d1a) 117948720

ESP:	116673091 116694723

PFLV:

114549821 114559808

GAT:	120808765 120817980

PPUG:

119196383 119210570(cacna2d1a)

AFB:	129108113 129112268

CLUM:

117726077(cacna2d1a) 117732029

PSWI:

130195737 130200419

MSAM:

119894006 119918165(cacna2d1a)

SCHU:

122871350 122875527

CUD:	121505378 121515429

ALAT:

119025044 119032573(cacna2d1a)

ASTR:

137589113 137594046

MZE:	101476728(cacna2d1) 101486293

ONL:	100705035(cacna2d1) 100705144

OAU:	116309808(cacna2d1a) 116318275

OLA:	101156213 101164397(cacna2d1)

OML:	112152678 112154516

CSAI:

133424606 133444303

XMA:	102232366 102238041

XCO:	114133417 114160855

XHE:	116707984(cacna2d1) 116736692

PRET:

103459225 103465999(cacna2d1)

PFOR:

103133825(cacna2d1) 103146204

PLAI:

106944868 106964832(cacna2d1)

PMEI:

106915080 106922236

GAF:	122826393(cacna2d1a) 122835732

PPRL:

129375519

CVG:	107085985 107099205

CTUL:

119773619 119789722(cacna2d1a)

GMU:	124856582 124882862

NFU:	107385644 107388870(cacna2d1)

KMR:	108230132 108235077(cacna2d1a)

ALIM:

106514761 106520335(cacna2d1)

NWH:	119416037 119428490(cacna2d1a)

AOCE:

111564003 111564876

MCEP:

124999775(cacna2d1a) 125015341

CSEM:

103380101 103382776

POV:	109624050(cacna2d1) 109632696

SSEN:

122766290(cacna2d1a) 122775663

HHIP:

117757218(cacna2d1a) 117762737

HSP:	118102011(cacna2d1a) 118109924

PPLT:

128428928 128445085

SMAU:

118289276 118315579

LCF:	108875137 108879646

SDU:	111224485 111228383(cacna2d1)

SLAL:

111653379 111671920

XGL:	120793255 120799453(cacna2d1a)

HCQ:	109523795 109526841

SSCV:

125970198 125992026

SBIA:

133493395(cacna2d1a) 133502180

PEE:	133396938(cacna2d1a) 133403146

PTAO:

133471884(cacna2d1a) 133477886

BPEC:

110161913(cacna2d1) 110166803

MALB:

109959825 109967519(cacna2d1)

BSPL:

114857729 114862133(cacna2d1a)

SJO:	128358351 128385197

SASA:

106561208 106573448 106576572

STRU:

115152047 115180504 115197760 115199102

OTW:	112219241 112245181 121843114

OMY:	110499865 110499867 110501950 110521553

OGO:	124016976 124036170

ONE:	115109800 115125157(cacna2d1)

OKI:	109866961 109879069 109879081

OKE:	118396257 118401180

SALP:

111962521

SNH:	120031842 120050077 120053242 120065854

CCLU:

121531951 121543412 121549722 121577445

ELS:	105018430 105020378

SFM:	108921141(cacna2d1) 108936376

PKI:	111833289 111846161(cacna2d1)

AANG:

118219259 118232093

LOC:	102697890(cacna2d1)

PSPA:

121318192 121319909

ARUT:

117415040 117419874

PSEX:

120534138

LCM:	102355436(CACNA2D1)

CMK:

RTP:

CPLA:

HOC:

LERI:

CIN:

SCLV:

SPU:

LPIC:

ARUN:

SKO:

DPX:	DAPPUDRAFT_324542

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

MRJ:

PPOI:

DSV:

RSAN:

RMP:

CSCU:

PTEP:

ABRU:

UDV:

SDM:	118198908 118204800

PVUL:

PMAX:

RPHI:

ATEN:

AMIL:

DGT:

XEN:

HMG:

Reference

PMID:22678293

Authors

Hoppa MB, Lana B, Margas W, Dolphin AC, Ryan TA

Title

alpha2delta expression sets presynaptic calcium channel abundance and release probability.

Journal

Nature 486:122-5 (2012)
DOI:10.1038/nature11033

Sequence

[hsa:781]

LinkDB

ORTHOLOGY: K04859

Entry

K04859                      KO

Symbol

CACNA2D2

Name

voltage-dependent calcium channel alpha-2/delta-2

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H02645

Cerebellar atrophy with seizures and variable developmental delay

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
   04261 Adrenergic signaling in cardiomyocytes
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
   05414 Dilated cardiomyopathy
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04859  CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2

Other DBs

GO:

0005245

TC:

8.A.18.2

Genes

HSA:	9254(CACNA2D2)

PTR:	460396(CACNA2D2)

PPS:	100995074(CACNA2D2)

GGO:	101126134(CACNA2D2)

PON:	100451685(CACNA2D2)

PPYG:

129033986(CACNA2D2)

NLE:	100594884(CACNA2D2)

HMH:	116473437(CACNA2D2)

SSYN:

129481044(CACNA2D2)

MCC:	702429(CACNA2D2)

MCF:	102115452(CACNA2D2)

MTHB:

126948632

MNI:	105480493(CACNA2D2)

CSAB:

103227681(CACNA2D2)

CATY:

105573729(CACNA2D2)

PANU:

101003565

TGE:	112618240(CACNA2D2)

MLEU:

105548976(CACNA2D2)

RRO:	104667936(CACNA2D2)

RBB:	108526929(CACNA2D2)

TFN:	117082068(CACNA2D2)

PTEH:

111555399(CACNA2D2)

CANG:

105509667(CACNA2D2)

CJC:	100408470(CACNA2D2)

SBQ:	101041145(CACNA2D2)

CIMI:

108306246(CACNA2D2)

ANAN:

105727736(CACNA2D2)

CSYR:

103255450(CACNA2D2)

MMUR:

105875001(CACNA2D2)

LCAT:

123623233(CACNA2D2)

PCOQ:

105827606(CACNA2D2)

OGA:	100965256(CACNA2D2)

MMU:	56808(Cacna2d2)

MCAL:

110301155(Cacna2d2)

MPAH:

110327210(Cacna2d2)

RNO:	300992(Cacna2d2)

MCOC:

116072134(Cacna2d2)

ANU:	117693330(Cacna2d2)

MUN:	110564620(Cacna2d2)

CGE:	100769472(Cacna2d2)

MAUA:

101827594(Cacna2d2)

PROB:

127237019(Cacna2d2)

PLEU:

114710954(Cacna2d2)

MORG:

121464258(Cacna2d2)

MFOT:

126499863

AAMP:

119809135(Cacna2d2)

NGI:	103750148(Cacna2d2)

HGL:	101710707(Cacna2d2)

CPOC:

100734097(Cacna2d2)

CCAN:

109693218(Cacna2d2)

DORD:

105994618(Cacna2d2)

DSP:	122095552(Cacna2d2)

PLOP:

125342682(Cacna2d2)

NCAR:

124992864

MMMA:

107143179(Cacna2d2)

OCU:

100340494

OPI:	101534779(CACNA2D2)

TUP:	102494398(CACNA2D2)

GVR:	103593717(CACNA2D2)

CFA:	100688870(CACNA2D2)

CLUD:

112665719(CACNA2D2)

VVP:	112910957(CACNA2D2)

VLG:	121494622(CACNA2D2)

NPO:	129522054(CACNA2D2)

AML:	100480599(CACNA2D2)

UMR:	103675085(CACNA2D2)

UAH:	113256916(CACNA2D2)

UAR:	123798700(CACNA2D2)

ELK:

111144160

LLV:

125079576

MPUF:

101681641(CACNA2D2)

MNP:	132011360(CACNA2D2)

MLK:	131823959(CACNA2D2)

NVS:	122909390(CACNA2D2)

ORO:	101372567(CACNA2D2)

EJU:	114225062(CACNA2D2)

ZCA:	113916580(CACNA2D2)

MLX:	118004992(CACNA2D2)

NSU:	110577612(CACNA2D2)

LWW:	102727619(CACNA2D2)

FCA:	101095887(CACNA2D2)

PYU:	121011239(CACNA2D2)

PCOO:

112852458(CACNA2D2)

PBG:	122487259(CACNA2D2)

PVIV:

125160829(CACNA2D2)

LRUF:

124523933

PTG:	102967999(CACNA2D2)

PPAD:

109247849(CACNA2D2)

PUC:

125930356

AJU:

106979199

HHV:	120229292(CACNA2D2)

BTA:	785909(CACNA2D2)

BOM:	102284671(CACNA2D2)

BIU:	109575879(CACNA2D2)

BBUB:

102393363(CACNA2D2)

BBIS:

104997282(CACNA2D2)

CHX:	102175908(CACNA2D2)

OAS:	101115165(CACNA2D2)

BTAX:

128054644(CACNA2D2)

ODA:	120868312(CACNA2D2)

CCAD:

122424547(CACNA2D2)

MBEZ:

129547871(CACNA2D2)

SSC:	100517557(CACNA2D2)

CFR:	102517655(CACNA2D2)

CBAI:

105080307(CACNA2D2)

CDK:	105087368(CACNA2D2)

VPC:	102545991(CACNA2D2)

BACU:

103003434(CACNA2D2)

BMUS:

118904549(CACNA2D2)

LVE:	103076085(CACNA2D2)

OOR:	101280475(CACNA2D2)

DLE:	111174353(CACNA2D2)

PCAD:

102993151

PSIU:

116762009(CACNA2D2)

NASI:

112400712(CACNA2D2)

ECB:	100061645(CACNA2D2)

EPZ:	103559270(CACNA2D2)

EAI:	106830655(CACNA2D2)

MYB:	102239809(CACNA2D2)

MMYO:

118668441(CACNA2D2)

MDT:	132215821(CACNA2D2)

PKL:	118715633(CACNA2D2)

EFUS:

103298527(CACNA2D2)

MNA:	107540175(CACNA2D2)

DRO:	112309612(CACNA2D2)

SHON:

118989438(CACNA2D2)

AJM:	119036703(CACNA2D2)

PDIC:

114501400(CACNA2D2)

PHAS:

123830783(CACNA2D2)

MMF:	118633017(CACNA2D2)

PPAM:

129087701(CACNA2D2)

HAI:	109377855(CACNA2D2)

RFQ:	117037054(CACNA2D2)

PALE:

102891516(CACNA2D2)

PGIG:

120582393(CACNA2D2)

PVP:	105295184(CACNA2D2)

RAY:	107513293(CACNA2D2)

MJV:	108402854(CACNA2D2)

TOD:	119260629(CACNA2D2)

SARA:

101554867(CACNA2D2)

SETR:

126014017(CACNA2D2)

LAV:	100667110(CACNA2D2)

TMU:

101344991

ETF:	101664293(CACNA2D2)

DNM:	101442552(CACNA2D2)

MDO:	100028700(CACNA2D2)

GAS:	123230768(CACNA2D2)

SHR:	100918097(CACNA2D2)

AFZ:

127554393

PCW:	110217120(CACNA2D2)

TVP:	118831570(CACNA2D2)

OAA:	100088778(CACNA2D2)

GGA:	430150(CACNA2D2)

PCOC:

116232309(CACNA2D2)

MGP:	100543169(CACNA2D2)

CJO:	107319584(CACNA2D2)

TPAI:

128078381(CACNA2D2)

LMUT:

125698548(CACNA2D2)

NMEL:

110404640(CACNA2D2)

APLA:

113845023(CACNA2D2)

ACYG:

106042802(CACNA2D2)

CATA:

118248051(CACNA2D2)

AFUL:

116492948(CACNA2D2)

TGU:	100232652(CACNA2D2)

LSR:	110469921(CACNA2D2)

SCAN:

103817134(CACNA2D2)

PMOA:

120513965(CACNA2D2)

OTC:	121347336(CACNA2D2)

PRUF:

121352495(CACNA2D2)

GFR:	102043893(CACNA2D2)

FAB:	101819244(CACNA2D2)

OMA:	130258415(CACNA2D2)

PHI:	102113307(CACNA2D2)

PMAJ:

107210462(CACNA2D2)

CCAE:

111935189(CACNA2D2)

CCW:	104683432(CACNA2D2)

CBRC:

103614362(CACNA2D2)

ETL:	114058765(CACNA2D2)

ZAB:	102070590(CACNA2D2)

SVG:	106849227(CACNA2D2)

MMEA:

130574656(CACNA2D2)

HRT:	120758105(CACNA2D2)

SATI:

136366059(CACNA2D2)

FPG:	101920293(CACNA2D2)

FCH:	102049917(CACNA2D2)

SHAB:

115614605(CACNA2D2)

ACUN:

113484677(CACNA2D2)

TALA:

116959471(CACNA2D2)

ACHC:

115333325(CACNA2D2)

HLE:	104828112(CACNA2D2)

AGEN:

126049842

GCL:

127021534

LDI:

104342569

DPUB:

104300409(CACNA2D2)

EGZ:	104126694(CACNA2D2)

NNI:	104008753(CACNA2D2)

PADL:

103915105(CACNA2D2)

AFOR:

103898271(CACNA2D2)

CLV:	102096453(CACNA2D2)

CUCA:

104066718(CACNA2D2)

CPEA:

104388143(CACNA2D2)

CVF:	104291988(CACNA2D2)

RTD:	128915756(CACNA2D2)

AAM:	106485955(CACNA2D2)

AROW:

112972975(CACNA2D2)

NPD:	112953054(CACNA2D2)

TGT:	104569611(CACNA2D2)

DNE:	112986201(CACNA2D2)

ASN:	102380559(CACNA2D2)

AMJ:	102558555(CACNA2D2)

CPOO:

109318298(CACNA2D2)

GGN:	109289208(CACNA2D2)

PSS:	102448752(CACNA2D2)

CMY:	102944836(CACNA2D2)

CCAY:

125639550(CACNA2D2)

DCC:	119859072(CACNA2D2)

CPIC:

101944341(CACNA2D2)

TST:	117880201(CACNA2D2)

CABI:

116825430(CACNA2D2)

MRV:	120409322(CACNA2D2)

ACS:	100564773(cacna2d2)

ASAO:

132769139(CACNA2D2)

PVT:	110076599(CACNA2D2)

SUND:

121922117(CACNA2D2)

PBI:	103063628(CACNA2D2)

PMUR:

107288727(CACNA2D2)

CTIG:

120315014(CACNA2D2)

TSR:	106542392(CACNA2D2)

PGUT:

117678869(CACNA2D2)

APRI:

131190191(CACNA2D2)

PTEX:

113453910(CACNA2D2)

NSS:	113415699(CACNA2D2)

VKO:	123034117(CACNA2D2)

PMUA:

114590871(CACNA2D2)

PRAF:

128408142(CACNA2D2)

ZVI:	118080594(CACNA2D2)

HCG:	128341561(CACNA2D2)

GJA:	107116010(CACNA2D2)

STOW:

125428338(CACNA2D2)

EMC:	129328413(CACNA2D2)

XLA:	108714609(cacna2d2.L) 108715833(cacna2d2.S)

XTR:	100038148(cacna2d2)

NPR:	108801947(CACNA2D2)

RTEM:

120944945(CACNA2D2)

BBUF:

120978529(CACNA2D2)

BGAR:

122922414(CACNA2D2)

MUO:	115472499(CACNA2D2)

GSH:	117351213(CACNA2D2)

DRE:	541376(cacna2d2a) 568759(cacna2d2b)

SRX:	107707259 107720977 107744381

SANH:

107653164 107655410 107666002 107696459

SGH:	107558272 107587574 107595439

CCAR:

109046398 109091194 109092019

CAUA:

113050207 113077395 113081272 113092159 113103988

CGIB:

127942915 127959340 128015996

PTET:

122327305(cacna2d2b) 122346648(cacna2d2a)

LROH:

127153415(cacna2d2b) 127166463(cacna2d2a)

OMC:	131530733(cacna2d2b) 131541863(cacna2d2a)

PPRM:

120475648(cacna2d2b) 120493922(cacna2d2a)

RKG:	130078206(cacna2d2b) 130104010(cacna2d2a)

MAMB:

125263541(cacna2d2b) 125273627(cacna2d2a)

CIDE:

127514315 127519739

CERY:

137010626(cacna2d2a) 137029249(cacna2d2b)

MASI:

127438042 127439111 127446285 127448953

TROS:

130548699(cacna2d2b) 130556461(cacna2d2a)

TDW:	130424337(cacna2d2a) 130430101(cacna2d2b)

MANU:

129450723(cacna2d2a) 129453207 129453300

IPU:	108254802(cacna2d2b) 108271986(cacna2d2a)

IFU:	128614652(cacna2d2a) 128625264(cacna2d2b)

PHYP:

113537403(cacna2d2) 113539524

SMEO:

124383136(cacna2d2a) 124402445(cacna2d2b)

TFD:	113637049(cacna2d2b) 113643105(cacna2d2a)

TVC:	132837790 132844648(cacna2d2a)

TRN:	134301877 134316338(cacna2d2a)

AMEX:

103024805(cacna2d2a) 103030690

CMAO:

118799797(cacna2d2b) 118808552(cacna2d2a)

EEE:	113571596 113583820

CHAR:

105895841(cacna2d2a) 105903398

TRU:	101072949 101074206(cacna2d2)

TFS:	130524129 130524876(cacna2d2a)

TNG:	GSTEN00027409G001 GSTEN00027514G001

LCO:	104919490(cacna2d2) 104931346

NCC:	104967509 104967865

TBEN:

117489464(cacna2d2a) 117489956

CGOB:

115007738(cacna2d2) 115008089

PGEO:

117446528(cacna2d2a) 117446827

GACU:

117548066(cacna2d2a) 117548137

EMAC:

134882643(cacna2d2a) 134883435

ELY:	117257103(cacna2d2a) 117257156

EFO:	125894114 125897887(cacna2d2a)

PLEP:

121957531(cacna2d2a) 121958673

SLUC:

116041548 116051268(cacna2d2a)

ECRA:

117942962(cacna2d2a) 117943519

ESP:	116687866 116688656(cacna2d2)

PFLV:

114553552(cacna2d2) 114554347

GAT:	120834646(cacna2d2a) 120835803

PPUG:

119229665(cacna2d2a) 119230157

AFB:	129105681 129105778(cacna2d2a)

CLUM:

117730790(cacna2d2a) 117730882

PSWI:

130207714(cacna2d2a) 130208271

MSAM:

119886343(cacna2d2a) 119886678

SCHU:

122861432 122885222(cacna2d2a)

CUD:	121506874 121507356(cacna2d2a)

ALAT:

119021699(cacna2d2a) 119021716

ASTR:

137595510 137596007(cacna2d2a)

MZE:	101472221 101483348(cacna2d2)

ONL:	100701765 102079371(cacna2d2)

OAU:	116313694 116334216(cacna2d2a)

OLA:	101155679(cacna2d2) 101156079

OML:	112144693 112144966(cacna2d2a)

CSAI:

133448562 133448632(cacna2d2a)

XMA:	102223620 102227354

XCO:	114135049 114135771

XHE:	116711224(cacna2d2)

PRET:

103464512(cacna2d2) 103464608

PFOR:

103136979(cacna2d2) 103137938

PLAI:

106959036 106962479(cacna2d2)

PMEI:

106914942 106925051(cacna2d2)

GAF:	122833924(cacna2d2a) 122834518(cacna2d2b)

PPRL:

129356936(cacna2d2b) 129358402(cacna2d2a)

CVG:	107089332(cacna2d2) 107102913

CTUL:

119775068(cacna2d2a) 119779980

GMU:	124856417(cacna2d2a) 124856889(cacna2d2b)

NFU:	107385140 107385904(cacna2d2)

KMR:	108231343(cacna2d2a) 108247395

ALIM:

106516038 106516127(cacna2d2) 106534307

NWH:	119411804(cacna2d2a) 119412468

AOCE:

111563210 111579902

MCEP:

125006927 125007403(cacna2d2a)

CSEM:

103385691(cacna2d2) 103385816

POV:	109638508 109638546(cacna2d2)

SSEN:

122760953 122768754(cacna2d2a)

HHIP:

117761137 117762118(cacna2d2a)

HSP:	118104804(cacna2d2a) 118105519

PPLT:

128449969(cacna2d2a) 128454289(cacna2d2b)

SMAU:

118308962(cacna2d2a) 118309320

LCF:	108889381 108899190(cacna2d2a)

SDU:	111222853(cacna2d2) 111222860

SLAL:

111653834(cacna2d2) 111660766

XGL:	120807053(cacna2d2a) 120807540

HCQ:	109507586 109522260

SSCV:

125977091 125977160

SBIA:

133507732 133508079(cacna2d2a)

PEE:	133408985 133409304(cacna2d2a)

PTAO:

133482993(cacna2d2a) 133483884

BPEC:

110168563(cacna2d2) 110168769

MALB:

109952382 109959020

BSPL:

114855023(cacna2d2a) 114856153

SJO:	128355174 128355294(cacna2d2a)

SASA:

106565177 106566000 106582605

STRU:

115150944 115207482 115208238

OTW:	112214695(cacna2d2b) 112254289 112263077

OMY:	110493268 110494014(cacna2d2b) 110527806

OGO:	124002966 124003879 124031552

ONE:	115136432(cacna2d2) 115142736

OKI:	109878204 109890883 109892502

OKE:	118388289 118389044 118399834

SALP:

111970080(cacna2d2) 111970558 112070377

SNH:	120020369 120021849 120021859 120065592

CCLU:

121565811 121574858 121575495 121578410(cacna2d2a)

ELS:	105025419(cacna2d2) 105028112

SFM:	108925615(cacna2d2) 108933831

PKI:	111848782(cacna2d2) 111860018

AANG:

118208386(cacna2d2a) 118211814

LOC:	102697422(cacna2d2)

PSPA:

121298155 121328816

ARUT:

117412565 117963518(cacna2d2a)

LCM:	102364100(CACNA2D2)

CMK:	103176814(cacna2d2a)

RTP:	109919291(cacna2d2a)

CPLA:

122559124(cacna2d2a)

HOC:	132822039(cacna2d2a)

LERI:

129704613(cacna2d2a)

PMRN:

116942379 116949362 116951295

LRJ:	133342630 133349455 133356411

BFO:	118416228 118428210

BBEL:

109465163 109477080 109486502

APLC:

FOC:

TPAL:

IEL:

HAME:

HAZT:

LSM:

TCF:

CVS:

LGI:	LOTGIDRAFT_165858 LOTGIDRAFT_238600

PVUL:

126817571 126817572

PCAN:

112571742

BGT:

106065960

GAE:	121368950 121374351

HRF:	124115378 124116612

HRJ:	124267955 124290447

CRG:	105338822 105342560

CANU:

128160483 128165300

CVN:	111108179 111118277 111121709

OED:	125655910 125670206

MYI:

PMAX:

MMER:

RPHI:

DPOL:

MAEA:

OBI:	106868291 106878181

OSN:

LJP:

LAK:

LLON:

NVE:

AMIL:

SPIS:

DGT:

XEN:

Reference

PMID:12555074

Authors

Carboni GL, Gao B, Nishizaki M, Xu K, Minna JD, Roth JA, Ji L

Title

CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity.

Journal

Oncogene 22:615-26 (2003)
DOI:10.1038/sj.onc.1206134

Sequence

[hsa:9254]

LinkDB

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