KEGG ORTHOLOGY: K04853

ORTHOLOGY: K04853

Entry

K04853                      KO

Symbol

CACNA1F, CAV1.4

Name

voltage-dependent calcium channel L type alpha-1F

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04270

Vascular smooth muscle contraction

map04723

Retrograde endocannabinoid signaling

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04921

Oxytocin signaling pathway

map04924

Renin secretion

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04929

GnRH secretion

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05207

Chemical carcinogenesis - receptor activation

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00481

Cone-rod dystrophy and cone dystrophy

H00690

Aland Island eye disease

H00787

Congenital stationary night blindness

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04020 Calcium signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04024 cAMP signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04022 cGMP-PKG signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04929 GnRH secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04912 GnRH signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04921 Oxytocin signaling pathway
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04935 Growth hormone synthesis, secretion and action
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04924 Renin secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04925 Aldosterone synthesis and secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04927 Cortisol synthesis and secretion
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04261 Adrenergic signaling in cardiomyocytes
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04270 Vascular smooth muscle contraction
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09156 Nervous system
   04727 GABAergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04725 Cholinergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04726 Serotonergic synapse
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   04723 Retrograde endocannabinoid signaling
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05020 Prion disease
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05022 Pathways of neurodegeneration - multiple diseases
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
   05414 Dilated cardiomyopathy
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F

Other DBs

GO:

0005245

TC:	1.A.1.11.11

Genes

HSA:	778(CACNA1F)

PTR:	740711(CACNA1F)

PPS:	100988624(CACNA1F)

GGO:	101131714(CACNA1F)

PON:	100431752(CACNA1F)

PPYG:

129023840(CACNA1F)

NLE:	100590475(CACNA1F)

HMH:	116811686(CACNA1F)

SSYN:

129475606(CACNA1F)

MCC:	715787(CACNA1F)

MCF:	102119841(CACNA1F)

MTHB:

126945535

MNI:	105493928(CACNA1F)

CSAB:

103231971(CACNA1F)

CATY:

105573107(CACNA1F)

PANU:

101019865(CACNA1F)

TGE:	112614995(CACNA1F)

MLEU:

105547696(CACNA1F)

RRO:	104661816(CACNA1F)

RBB:

108521361

TFN:	117077518(CACNA1F)

CANG:

105514987(CACNA1F)

CJC:	100386041(CACNA1F)

SBQ:	101034685(CACNA1F)

CIMI:

108293049(CACNA1F)

ANAN:

105730410(CACNA1F)

CSYR:

103277252(CACNA1F)

MMUR:

105856433(CACNA1F)

LCAT:

123628833(CACNA1F)

PCOQ:

105816783(CACNA1F)

OGA:	100962519(CACNA1F)

MMU:	54652(Cacna1f)

MCAL:

110286673(Cacna1f)

MPAH:

110313596(Cacna1f)

RNO:	114493(Cacna1f)

MCOC:

116102419(Cacna1f)

ANU:	117695376(Cacna1f)

MUN:	110561910(Cacna1f)

CGE:	100757994(Cacna1f)

MAUA:

101830198(Cacna1f)

PROB:

127218370(Cacna1f)

PLEU:

114701281(Cacna1f)

MORG:

121442677 121444334

MFOT:

126512843

AAMP:

119804579(Cacna1f)

NGI:	103741673(Cacna1f)

HGL:	101722090(Cacna1f)

CPOC:

100720484(Cacna1f)

CCAN:

109697195(Cacna1f)

DORD:

105997824(Cacna1f)

DSP:	122098776(Cacna1f)

PLOP:

125343296(Cacna1f)

NCAR:

124971751

MMMA:

107159825(Cacna1f)

OCU:

100357261

OPI:	101519864(CACNA1F)

TUP:	102482779(CACNA1F)

GVR:	103602700(CACNA1F)

CFA:	480915(CACNA1F)

CLUD:

112673110(CACNA1F)

VVP:	112907237(CACNA1F)

VLG:	121483414(CACNA1F)

NPO:	129517804(CACNA1F)

AML:	100468661(CACNA1F)

UMR:	103667625(CACNA1F)

UAH:	113265950(CACNA1F)

UAR:	123797184(CACNA1F)

ELK:

111150407

LLV:

125091668

MPUF:

101689134(CACNA1F)

MNP:	132007466(CACNA1F)

MLK:	131821118(CACNA1F)

NVS:	122897554(CACNA1F)

ORO:	101364481(CACNA1F)

EJU:	114216787(CACNA1F)

ZCA:	113931031(CACNA1F)

MLX:	118008972(CACNA1F)

NSU:	110570742(CACNA1F)

LWW:	102742095(CACNA1F)

FCA:	101080870(CACNA1F)

PYU:	121026060(CACNA1F)

PCOO:

112871144(CACNA1F)

PBG:	122477612(CACNA1F)

PVIV:

125157244(CACNA1F)

LRUF:

124509536

PTG:	102950547(CACNA1F)

PPAD:

109248097(CACNA1F)

PUC:

125931680

AJU:

106988999

HHV:	120221013(CACNA1F)

BTA:	509779(CACNA1F)

BOM:	102286805(CACNA1F)

BIU:	109554975(CACNA1F)

BBUB:

102407399(CACNA1F)

CHX:	102189746(CACNA1F)

OAS:	101104552(CACNA1F)

BTAX:

128070004(CACNA1F)

ODA:	120881638(CACNA1F)

CCAD:

122434769(CACNA1F)

MBEZ:

129564275(CACNA1F)

SSC:	100514745(CACNA1F)

CFR:	102504151(CACNA1F)

CBAI:

105079415(CACNA1F)

CDK:	105103284(CACNA1F)

VPC:	102540844(CACNA1F)

BACU:

102998540(CACNA1F)

BMUS:

118888578(CACNA1F)

LVE:	103082192(CACNA1F)

OOR:	101281199(CACNA1F)

DLE:	111169490(CACNA1F)

PCAD:

102992313(CACNA1F)

PSIU:

116747382(CACNA1F)

NASI:

112399841(CACNA1F)

ECB:	100062861(CACNA1F)

EPZ:	103543955(CACNA1F)

EAI:	106826963(CACNA1F)

MYB:	102260789(CACNA1F)

MYD:	102771414(CACNA1F)

MMYO:

118654729(CACNA1F)

MLF:	102434312(CACNA1F)

MDT:	132224732(CACNA1F)

PKL:	118731815(CACNA1F)

EFUS:

103301304(CACNA1F)

MNA:	107541372(CACNA1F)

DRO:	112322357(CACNA1F)

SHON:

118998346(CACNA1F)

AJM:	119059521(CACNA1F)

PDIC:

114505705(CACNA1F)

PHAS:

123832713(CACNA1F)

MMF:	118635608(CACNA1F)

PPAM:

129065030(CACNA1F)

HAI:	109374806(CACNA1F)

RFQ:	117023033(CACNA1F)

PALE:

102893611(CACNA1F)

PGIG:

120587067(CACNA1F)

PVP:	105309056(CACNA1F)

RAY:	107514999(CACNA1F)

MJV:	108404213(CACNA1F)

TOD:	119246715(CACNA1F)

SARA:

101548753(CACNA1F)

SETR:

125999147(CACNA1F)

LAV:	100674649(CACNA1F)

TMU:

101340818

ETF:	101662493(CACNA1F)

DNM:	101421427(CACNA1F)

MDO:	100019531(CACNA1F)

SHR:	100927554(CACNA1F)

AFZ:

127543177

PCW:	110201034(CACNA1F)

OAA:	100075939(CACNA1F)

PCOC:

116240105(CACNA1F)

LMUT:

125687783

ACYG:

106029551(CACNA1F)

CATA:

118261499

AFUL:

116501486

LSR:

110482322

PMOA:

120506954(CACNA1F)

OTC:	121339170(CACNA1F)

PRUF:

121362313

FAB:

101817703

OMA:	130263362(CACNA1F)

PHI:	102111116(CACNA1F)

CCW:	120412196(CACNA1F)

CBRC:

103618144

ZLE:	135460883(CACNA1F)

MMEA:

130587072

HRT:	120748203(CACNA1F)

FPG:

101922071

FCH:

102046341

ACHC:

115338229(CACNA1F)

HLE:

104836181

AGEN:

126035178

CLV:

102089966

CUCA:

104065626(CACNA1F)

AAM:	106493905(CACNA1F)

AROW:

112972618

ASN:	102368804(CACNA1F)

AMJ:	102563169(CACNA1F)

CCAY:

125628302

DCC:	119847431(CACNA1F)

CPIC:

101934179

CABI:

116823939

MRV:	120388192(CACNA1F)

ACS:	100565753(cacna1f)

ASAO:

132767858(CACNA1F)

PVT:	110078615(CACNA1F)

SUND:

121920504(CACNA1F)

PBI:	103051695(CACNA1F)

PMUR:

107284195(CACNA1F)

CTIG:

120311308(CACNA1F)

PGUT:

117675658(CACNA1F)

APRI:

131191024(CACNA1F)

PTEX:

113443408(CACNA1F)

NSS:	113417797(CACNA1F)

VKO:	123029960(CACNA1F)

PMUA:

114587594(CACNA1F)

PRAF:

128404904(CACNA1F)

ZVI:	118097569(CACNA1F)

HCG:	128343579(CACNA1F)

GJA:

107117359

STOW:

125428467(CACNA1F)

EMC:	129346029(CACNA1F)

XLA:	100462913(cacna1f.L)

XTR:	100485906(cacna1f)

NPR:

108788491

RTEM:

120913037(CACNA1F)

BBUF:

120977192(CACNA1F)

BGAR:

122919691(CACNA1F)

GSH:	117349072(CACNA1F)

DRE:	559964(cacna1fb) 793708(cacna1fa)

SRX:	107723069 107731232 107745766 107756819

SANH:

107668072 107695300

SGH:	107548248 107549945 107550115

CCAR:

109065543 109087149

CAUA:

113070706 113076440 113079157 113087728

CGIB:

127964170 128018341 128018705

PTET:

122350026(cacna1fa) 122350696(cacna1fb)

LROH:

127169482(cacna1fa) 127169880(cacna1fb)

OMC:	131546303(cacna1fb) 131546383(cacna1fa)

PPRM:

120469151(cacna1fb) 120473866(cacna1fa)

RKG:	130081967(cacna1fa) 130094676(cacna1fb)

MAMB:

125279615(cacna1fb) 125280153(cacna1fa)

CIDE:

127517750 127517829

CERY:

137026362(cacna1fb) 137026591(cacna1fa)

MASI:

127414877 127415138 127424230

TROS:

130567680(cacna1fa) 130567834(cacna1fb)

TDW:	130407254(cacna1fa) 130440415(cacna1fb)

MANU:

129413518(cacna1fa) 129414338(cacna1fb)

IPU:	108265065(cacna1fb) 108265094(cacna1fa)

IFU:	128607445(cacna1fa) 128607852(cacna1fb)

PHYP:

113528653 113533319

SMEO:

124399485(cacna1fa) 124399904(cacna1fb)

TFD:	113656188(cacna1fb) 113656253(cacna1fa)

TVC:	132853295(cacna1fb) 132853808(cacna1fa)

TRN:	134318071(cacna1fa) 134318153(cacna1fb)

AMEX:

103033957(cacna1fb) 103034295(cacna1fa)

CMAO:

118813159(cacna1fb) 118813635(cacna1fa)

EEE:	113578747(cacna1f) 113579098

CHAR:

105893627(cacna1fa) 105898895(cacna1fb)

TRU:	101077620(cacna1f) 101079199

TFS:	130529900 130530283

TNG:	GSTEN00023513G001 GSTEN00026488G001

LCO:	104933125 104935494

TBEN:

117477467(cacna1fa)

CGOB:

115005436 115011426(cacna1f)

PGEO:

117449586

GACU:

117558053 117563145

EMAC:

134868208(cacna1fb) 134870830(cacna1fa)

ELY:	117257982(cacna1fb) 117258407(cacna1fa)

EFO:	125891630(cacna1fa) 125891672(cacna1fb)

PLEP:

121946427

SLUC:

116043571(cacna1fa) 116045489(cacna1fb)

ECRA:

117947003(cacna1fa)

ESP:

116692878

PFLV:

114558250

GAT:	120814961(cacna1fb) 120828763(cacna1fa)

PPUG:

119222360(cacna1fb) 119223125(cacna1fa)

AFB:	129099479(cacna1fa)

CLUM:

117733899(cacna1fa) 117734083(cacna1fb)

PSWI:

130198907(cacna1fb) 130198943(cacna1fa)

MSAM:

119905055(cacna1fb) 119905094(cacna1fa)

SCHU:

122883241(cacna1fb) 122883424(cacna1fa)

CUD:	121516935(cacna1fa) 121517368(cacna1fb)

ALAT:

119022437(cacna1fa) 119023017(cacna1fb)

MZE:	101472797 101480057

ONL:	100700615 100706871

OAU:	116319501(cacna1fa) 116335447(cacna1fb)

OLA:	101171727 101171913

OML:	112158663(cacna1fb) 112158801(cacna1fa)

CSAI:

133456705(cacna1fa) 133456958(cacna1fb)

XMA:	102223947 102230940

XCO:	114141072 114141251

XHE:	116708807 116722696

PRET:

103460216 103467718

PFOR:

103131960 103131961 103139061(cacna1f)

PLAI:

106935811 106942295 106954626(cacna1f)

PMEI:

106909745 106915898(cacna1f)

GAF:	122819169(cacna1fa) 122841771(cacna1fb)

PPRL:

129370128(cacna1fa)

CVG:	107095949(cacna1f) 107099706

CTUL:

119792002(cacna1fb) 119799513(cacna1fa)

GMU:	124867625(cacna1fa) 124868417(cacna1fb)

NFU:	107390498(cacna1f) 107391407

KMR:	108228711 108232078

ALIM:

106519282(cacna1f) 106523414 106533880

NWH:

119417562

AOCE:

111580242

MCEP:

125000377(cacna1fa) 125008328(cacna1fb)

CSEM:

103384398 103385395(cacna1f)

POV:	109642986 109643812

SSEN:

122776983(cacna1fb) 122777519(cacna1fa)

HHIP:

117764489(cacna1fa) 117765247(cacna1fb)

HSP:	118111156(cacna1fb) 118111219(cacna1fa)

PPLT:

128442156(cacna1fb) 128442978(cacna1fa)

SMAU:

118316446(cacna1fb) 118316681(cacna1fa)

LCF:	108882181(cacna1fa) 108890565(cacna1fb)

SDU:	111234857 111235435

SLAL:

111654197 111669629

XGL:	120803456(cacna1fa) 120804054(cacna1fb)

HCQ:	109510493 109512986(cacna1f)

SSCV:

125988118 125989504

SBIA:

133511311(cacna1fb) 133514547

PEE:	133401401(cacna1fa) 133407340(cacna1fb)

PTAO:

133476776(cacna1fa) 133485243(cacna1fb)

BPEC:

110154433 110164475(cacna1f)

MALB:

109953071

BSPL:

114858189(cacna1fb) 114858500(cacna1fa)

SJO:	128357648(cacna1fa) 128357695

SASA:

106572493

STRU:

115166484 115168069

OTW:

112221526

OMY:	110512770(cacna1fb) 110531219

OGO:	124032106 124032399(cacna1fb) 124045931

ONE:	115101902 115132631

OKI:

109869700

OKE:	118359894 118360554 118379413(cacna1fb)

SALP:

111966955

SNH:

120061553

CCLU:

121537216 121538138(cacna1fb) 121546475

ELS:	105008776 105022404

SFM:	108918279 108934768

PKI:	111847817 111857113

AANG:

118207210(cacna1fb) 118210606

PSPA:

121305498

ARUT:

117967960

PSEX:

120542743

LCM:	102353236(CACNA1F)

PMRN:

116952741

» show all

Reference

PMID:25468907

Authors

Lee A, Wang S, Williams B, Hagen J, Scheetz TE, Haeseleer F

Title

Characterization of Cav1.4 complexes (alpha11.4, beta2, and alpha2delta4) in HEK293T cells and in the retina.

Journal

J Biol Chem 290:1505-21 (2015)
DOI:10.1074/jbc.M114.607465

Sequence

[hsa:778]

Reference

PMID:9662399

Authors

Strom TM, Nyakatura G, Apfelstedt-Sylla E, Hellebrand H, Lorenz B, Weber BH, Wutz K, Gutwillinger N, Ruther K, Drescher B, Sauer C, Zrenner E, Meitinger T, Rosenthal A, Meindl A

Title

An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness.

Journal

Nat Genet 19:260-3 (1998)
DOI:10.1038/940

Sequence

[hsa:778]

LinkDB

DBGET integrated database retrieval system