KEGG   ORTHOLOGY: K05295
Entry
K05295                      KO                                     
Symbol
E1.1.1.149
Name
20alpha-hydroxysteroid dehydrogenase [EC:1.1.1.149]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K05295  E1.1.1.149; 20alpha-hydroxysteroid dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.149  20alpha-hydroxysteroid dehydrogenase
     K05295  E1.1.1.149; 20alpha-hydroxysteroid dehydrogenase
Other DBs
RN: R02207 R02209 R03325 R08958 R08959
GO: 0047006
Genes
MMU: 105349(Akr1c18)
RNO: 171516(Akr1c3)
CGE: 100768666
MAUA: 101841800
MORG: 121432666
AAMP: 119816162
DORD: 105980417
DSP: 122113030
HAME: 121859286
Reference
PMID:6935192
  Authors
Strickler RC, Tobias B, Covey DF
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J Biol Chem 256:316-21 (1981)
LinkDB

KEGG   ORTHOLOGY: K00212
Entry
K00212                      KO                                     
Symbol
AKR1C1
Name
20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
Pathway
map00140  Steroid hormone biosynthesis
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.149  20alpha-hydroxysteroid dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.20  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
Other DBs
RN: R02207 R02209 R03325 R07015 R08958 R08959 R09420
GO: 0047006 0047115
Genes
HSA: 1645(AKR1C1)
PTR: 100607996
PPS: 100986729
GGO: 101146324 115936027
PON: 100171658(AKR1C1) 100189776
NLE: 100605934
MCC: 711198(AKR1C1) 711360(AKR1C2)
MCF: 101865536(AKR1C1) 102141103
CSAB: 103237807 103237808
CATY: 105587685 105587688
PANU: 101023297
CJC: 100404656(AKR1C1)
SBQ: 101042532
MCAL: 110308710
MPAH: 110315750
RNO: 307092(Akr1c1)
CGE: 100770100
PLEU: 114708030
NGI: 103725895
HGL: 101716553
CCAN: 109680485
OCU: 100348607(PGER1) 100352716
ECB: 100070570
EPZ: 103540778
EAI: 106827244
BBEL: 109473367
 » show all
Reference
PMID:8172617
  Authors
Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A
  Title
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.
  Journal
Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545
  Sequence
[hsa:1645]
Reference
  Authors
Higaki Y, Usami N, Shintani S, Ishikura S, El-Kabbani O, Hara A
  Title
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
  Journal
Chem Biol Interact 143-144:503-13 (2003)
DOI:10.1016/S0009-2797(02)00206-5
LinkDB

KEGG   ENZYME: 1.1.1.149
Entry
EC 1.1.1.149                Enzyme                                 
Name
20alpha-hydroxysteroid dehydrogenase;
20alpha-hydroxy steroid dehydrogenase;
20alpha-HSD;
20alpha-HSDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Reaction(IUBMB)
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ [RN:R03325]
Reaction(KEGG)
R03325;
(other) R02207 R02209 R08958 R08959
Substrate
17alpha,20alpha-dihydroxypregn-4-en-3-one [CPD:C04518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
17alpha-hydroxyprogesterone [CPD:C01176];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).
History
EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K05295  20alpha-hydroxysteroid dehydrogenase
Genes
HSA1645(AKR1C1)
PTR100607996
PPS100986729
GGO101146324 115936027
PON100171658(AKR1C1) 100189776
NLE100605934
MCC711198(AKR1C1) 711360(AKR1C2)
MCF101865536(AKR1C1) 102141103
CSAB103237807 103237808
CATY105587685 105587688
PANU101023297
TGE112631308 112631309
RRO104678924 104678925
RBB108532991 108532992
TFN117083548 117083560 117087703 117087714
CJC100404656(AKR1C1)
SBQ101042532
MMU105349(Akr1c18)
MCAL110308710
MPAH110315750
RNO171516(Akr1c3) 307092(Akr1c1)
MUN110540933 110542801
CGE100768666 100770100
MAUA101841800
PLEU114708030
MORG121432666
AAMP119816162
NGI103725895
HGL101716553
CPOC100722094 100724342 100724620
CCAN109680485
DORD105980417
DSP122113030
OCU100348607(PGER1) 100352716
OPI101525116 101525279 101526245 118759111
ECB100070570
EPZ103540778
EAI106827244
DNM101433871 101435315
GAS123247018 123248678
BBEL109473367
HAME121859286
 » show all
Reference
1  [PMID:4382486]
  Authors
Shikita M, Inano H, Tamaoki B.
  Title
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
  Journal
Biochemistry 6:1760-4 (1967)
DOI:10.1021/bi00858a026
Reference
2  [PMID:6935192]
  Authors
Strickler RC, Tobias B, Covey DF
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J Biol Chem 256:316-21 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.149
IUBMB Enzyme Nomenclature: 1.1.1.149
ExPASy - ENZYME nomenclature database: 1.1.1.149
BRENDA, the Enzyme Database: 1.1.1.149
CAS: 9040-08-8
LinkDB

KEGG   REACTION: R02207
Entry
R02207                      Reaction                               
Name
20alpha-Hydroxy-4-pregnen-3-one:NAD+ 20-oxidoreductase
Definition
20alpha-Hydroxy-4-pregnen-3-one + NAD+ <=> Progesterone + NADH + H+
Equation
Comment
NADP+ (see R02209)
Reaction class
RC00001  C00003_C00004
RC00139  C00410_C04042
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Orthology
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
K05295  20alpha-hydroxysteroid dehydrogenase [EC:1.1.1.149]
LinkDB

KEGG   REACTION: R02209
Entry
R02209                      Reaction                               
Name
20alpha-Hydroxy-4-pregnen-3-one:NADP+ 20-oxidoreductase
Definition
20alpha-Hydroxy-4-pregnen-3-one + NADP+ <=> Progesterone + NADPH + H+
Equation
Comment
NAD+ (see R02207)
Reaction class
RC00001  C00005_C00006
RC00139  C00410_C04042
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Orthology
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
K05295  20alpha-hydroxysteroid dehydrogenase [EC:1.1.1.149]
LinkDB

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