KEGG   ORTHOLOGY: K05371
Entry
K05371                      KO                                     
Symbol
pcyA
Name
phycocyanobilin:ferredoxin oxidoreductase [EC:1.3.7.5]
Pathway
map00860  Porphyrin metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K05371  pcyA; phycocyanobilin:ferredoxin oxidoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.5  phycocyanobilin:ferredoxin oxidoreductase
     K05371  pcyA; phycocyanobilin:ferredoxin oxidoreductase
Other DBs
RN: R05817
GO: 0050620
Genes
THIP: N838_14800
CCRO: CMC5_010270
BRA: BRADO1265
SYN: slr0116
SYZ: MYO_127170
SYY: SYNGTS_2691(slr0116)
SYT: SYNGTI_2690(slr0116)
SYS: SYNPCCN_2689(slr0116)
SYQ: SYNPCCP_2689(slr0116)
SYJ: D082_22710(pcyA)
SYC: syc0325_d
SYG: sync_1656(pcyA)
SYR: SynRCC307_1284(pcyA)
SYX: SynWH7803_1335(pcyA)
CYA: CYA_2492(pcyA)
CYB: CYB_0698(pcyA)
SYNR: KR49_02860
SYND: KR52_10550
SYH: Syncc8109_1464(pcyA)
SYNW: SynWH8103_01226(pcyA)
SYW: SYNW1084(PcyA)
CYI: CBM981_0635(pcyA)
PMA: Pro_0819(pcyA)
PMM: PMM0747(pcyA)
PMT: PMT_0590
PMB: A9601_08081(pcyA)
PMC: P9515_08371(pcyA)
PMF: P9303_16581(pcyA)
PMG: P9301_08071(pcyA)
PMH: P9215_08411(pcyA)
PMJ: P9211_10161(pcyA)
PME: NATL1_07831(pcyA)
PRC: EW14_0836
PRM: EW15_0833
AMR: AM1_5311(pcyA) AM1_C0185(pcyA)
TEL: tll2308
THN: NK55_08135(pcyA)
LET: O77CONTIG1_02243(pcyA)
HHG: XM38_011470(pcyA)
PSER: ABRG53_1939(pcyA)
GEN: GM3709_84
MAR: MAE_06540(pcyA)
MPK: VL20_1154
MVZ: myaer102_41190(pcyA)
CYL: AA637_01130(pcyA)
CYT: cce_3569
TER: Tery_4156
ARP: NIES39_C04490(pcyA)
PAGH: NIES204_09690(pcyA)
GVI: glr2589(pcyA)
GLJ: GKIL_0241(pcyA)
ANA: alr3707
NSH: GXM_04246
AVA: Ava_3585
NAZ: Aazo_0093
CALH: IJ00_12770
DOU: BMF77_00760(pcyA)
CTHE: Chro_2660
 » show all
Reference
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965
  Sequence
[npu:Npun_R5577] [ana:alr3707] [pmm:PMM0747]
LinkDB

KEGG   ENZYME: 1.3.7.5
Entry
EC 1.3.7.5                  Enzyme                                 
Name
phycocyanobilin:ferredoxin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
(3Z)-phycocyanobilin:ferredoxin oxidoreductase
Reaction(IUBMB)
(3Z)-phycocyanobilin + 4 oxidized ferredoxin = biliverdin IXalpha + 4 reduced ferredoxin [RN:R05817]
Reaction(KEGG)
R05817
Substrate
(3Z)-phycocyanobilin [CPD:C05786];
oxidized ferredoxin [CPD:C00139]
Product
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]
Comment
Catalyses the four-electron reduction of biliverdin IXalpha (2-electron reduction at both the A and D rings). Reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Flavodoxins can be used instead of ferredoxin. The direct conversion of biliverdin IXalpha (BV) to (3Z)-phycocyanolbilin (PCB) in the cyanobacteria Synechocystis sp. PCC 6803, Anabaena sp. PCC7120 and Nostoc punctiforme is in contrast to the proposed pathways of PCB biosynthesis in the red alga Cyanidium caldarium, which involves (3Z)-phycoerythrobilin (PEB) as an intermediate [2] and in the green alga Mesotaenium caldariorum, in which PCB is an isolable intermediate.
History
EC 1.3.7.5 created 2002, modified 2014
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K05371  phycocyanobilin:ferredoxin oxidoreductase
Genes
THIPN838_14800
CCROCMC5_010270
BRABRADO1265
SYNslr0116
SYZMYO_127170
SYYSYNGTS_2691(slr0116)
SYTSYNGTI_2690(slr0116)
SYSSYNPCCN_2689(slr0116)
SYQSYNPCCP_2689(slr0116)
SYJD082_22710(pcyA)
SYOC7I86_14075
SYCsyc0325_d
SYUM744_10520
SYFSynpcc7942_1225
SYDSyncc9605_1216
SYESyncc9902_1253
SYGsync_1656(pcyA)
SYRSynRCC307_1284(pcyA)
SYXSynWH7803_1335(pcyA)
SYPSYNPCC7002_A2228
CYACYA_2492(pcyA)
CYBCYB_0698(pcyA)
SYNESyn6312_0395
SYNPSyn7502_00698
SYNKKR100_09570
SYNRKR49_02860
SYNDKR52_10550
SYHSyncc8109_1464(pcyA)
SYNWSynWH8103_01226(pcyA)
SYVAWQ23_11115
SYLAWQ21_11270
SYNCCB0101_03290
DSLDacsa_1370
SYWSYNW1084(PcyA)
CGCCyagr_0488
CYICBM981_0635(pcyA)
PMAPro_0819(pcyA)
PMMPMM0747(pcyA)
PMTPMT_0590
PMNPMN2A_0151
PMIPMT9312_0755
PMBA9601_08081(pcyA)
PMCP9515_08371(pcyA)
PMFP9303_16581(pcyA)
PMGP9301_08071(pcyA)
PMHP9215_08411(pcyA)
PMJP9211_10161(pcyA)
PMENATL1_07831(pcyA)
PRCEW14_0836
PRMEW15_0833
CMPCha6605_4072 Cha6605_5190
AMRAM1_5311(pcyA) AM1_C0185(pcyA)
TVNNIES2134_122330
SLWBRW62_00515
TELtll2308
THNNK55_08135(pcyA)
THECFFX45_04990
LEPLepto7376_1732
LENLEP3755_09220
LETO77CONTIG1_02243(pcyA)
LBOLBWT_40310
KOVK9N68_26750
LSCKIK02_09905
LSKJ5X98_07980
HHGXM38_011470(pcyA)
PSEUPse7367_0675
PSERABRG53_1939(pcyA)
THEUHPC62_03130
GLPGlo7428_1223
GENGM3709_84
GEEGM3708_1581
CHONNIES4102_26370 NIES4102_35570
MARMAE_06540(pcyA)
MPKVL20_1154
MIQB5D77_01340
MVZmyaer102_41190(pcyA)
CANCyan10605_0885
CSNCyast_0449
CYLAA637_01130(pcyA)
HAOPCC7418_0757
ENNFRE64_11535
CYUUCYN_02910
CYTcce_3569
CWACwatDRAFT_2748
CYPPCC8801_1724
CYHCyan8802_1748
CYCPCC7424_1047
CYJCyan7822_1827
CYNCyan7425_4845
TERTery_4156
ARPNIES39_C04490(pcyA)
PAGHNIES204_09690(pcyA)
OXYHCG48_04630
MVAGD0A34_25505
LFSHFV01_24400
MICMic7113_1088
GEIGEI7407_0624
OACOscil6304_5423
ONIOsc7112_5795
MPROBJP34_13975 BJP34_33435
PHORJWS08_18145
CEPCri9333_2265
GVIglr2589(pcyA)
GLJGKIL_0241(pcyA)
GMLISF26_22255
ANAalr3707
NPUNpun_R5577
NOSNos7107_0069
NOPNos7524_2342
NONNOS3756_46100
NFLCOO91_03603 COO91_07958 COO91_07959
NOECLI64_15735
NSHGXM_04246
NEDHUN01_08725
AVAAva_3585
NAZAazo_0093
ANBANA_C20740
ACYAnacy_4481
AWAAA650_18265
ANNEH233_11320
CSGCylst_5677
RSINB6N60_02039
CALOCal7507_6148
CALTCal6303_1856
CALHIJ00_12770
RIVRiv7116_1341
FISFIS3754_15700
DOUBMF77_00760(pcyA)
DFSHGD76_15180
CCURIAR63_10760
AFLOHEQ12_00150
TOQHCG51_26975
NCNBZZ01_28505
CTHEChro_2660
PLPPle7327_1788
SCSSta7437_1515 Sta7437_2962
STANSTA3757_20420(pcyA) STA3757_39780
CERRGRSB_1795
 » show all
Reference
1  [PMID:11283349]
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965
  Sequence
[npu:Npun_R5577] [ana:alr3707] [pmm:PMM0747]
Reference
2
  Authors
Beale, S.I.
  Title
Biosynthesis of phycobilins.
  Journal
Chem Rev 93:785-802 (1993)
Reference
3  [PMID:9325294]
  Authors
Wu SH, McDowell MT, Lagarias JC.
  Title
Phycocyanobilin is the natural precursor of the phytochrome chromophore in the green alga Mesotaenium caldariorum.
  Journal
J Biol Chem 272:25700-5 (1997)
DOI:10.1074/jbc.272.41.25700
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.5
IUBMB Enzyme Nomenclature: 1.3.7.5
ExPASy - ENZYME nomenclature database: 1.3.7.5
BRENDA, the Enzyme Database: 1.3.7.5
CAS: 347401-12-1
LinkDB

KEGG   REACTION: R05817
Entry
R05817                      Reaction                               
Name
(3Z)-phycocyanobilin:ferredoxin oxidoreductase
Definition
Biliverdin + 4 Reduced ferredoxin <=> (3Z)-Phycocyanobilin + 4 Oxidized ferredoxin
Equation
C00500 + 4 C00138 <=> C05786 + 4 C00139
Reaction class
RC01573  C00500_C05786
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K05371  phycocyanobilin:ferredoxin oxidoreductase [EC:1.3.7.5]
Other DBs
RHEA: 15312
LinkDB

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