Entry
Definition
5 ATP + 3 L-4-Hydroxyphenylglycine + L-Arginine + L-Serine + H2O <=> 5 AMP + 5 Diphosphate + Nocardicin G + L-4-Hydroxyphenylglycyl-L-arginine
Equation
Comment
nocardicin nonribosomal peptide synthetase
(1) 3 L-pHPG + L-Arg + L-Ser + 5 ATP <=> Pro-nocardicin G + 5 AMP + 5 Diphosphate
(2) Pro-nocardicin G + H2O <=> Nocardicin G + L-pHPG-L-Arg
Reaction class
Pathway
rn01110 Biosynthesis of secondary metabolites
Module
M00736 Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Orthology
K19102 nocardicin nonribosomal peptide synthetase NocA
K19103 nocardicin nonribosomal peptide synthetase NocB
Reference
Authors
Gaudelli NM, Long DH, Townsend CA
Title
beta-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
Journal
Reference
Authors
Gaudelli NM, Townsend CA
Title
Epimerization and substrate gating by a TE domain in beta-lactam antibiotic biosynthesis.
Journal
LinkDB
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