KEGG   ORTHOLOGY: K05414
Entry
K05414                      KO                                     
Symbol
IFNA
Name
interferon alpha
Pathway
map04060  Cytokine-cytokine receptor interaction
map04151  PI3K-Akt signaling pathway
map04217  Necroptosis
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04936  Alcoholic liver disease
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05320  Autoimmune thyroid disease
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05414  IFNA; interferon alpha
   04151 PI3K-Akt signaling pathway
    K05414  IFNA; interferon alpha
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05414  IFNA; interferon alpha
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K05414  IFNA; interferon alpha
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05414  IFNA; interferon alpha
   04621 NOD-like receptor signaling pathway
    K05414  IFNA; interferon alpha
   04622 RIG-I-like receptor signaling pathway
    K05414  IFNA; interferon alpha
   04623 Cytosolic DNA-sensing pathway
    K05414  IFNA; interferon alpha
   04650 Natural killer cell mediated cytotoxicity
    K05414  IFNA; interferon alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05414  IFNA; interferon alpha
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05414  IFNA; interferon alpha
   05161 Hepatitis B
    K05414  IFNA; interferon alpha
   05160 Hepatitis C
    K05414  IFNA; interferon alpha
   05171 Coronavirus disease - COVID-19
    K05414  IFNA; interferon alpha
   05164 Influenza A
    K05414  IFNA; interferon alpha
   05162 Measles
    K05414  IFNA; interferon alpha
   05168 Herpes simplex virus 1 infection
    K05414  IFNA; interferon alpha
   05163 Human cytomegalovirus infection
    K05414  IFNA; interferon alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05414  IFNA; interferon alpha
   05169 Epstein-Barr virus infection
    K05414  IFNA; interferon alpha
   05165 Human papillomavirus infection
    K05414  IFNA; interferon alpha
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05414  IFNA; interferon alpha
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K05414  IFNA; interferon alpha
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05414  IFNA; interferon alpha
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05414  IFNA; interferon alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05414  IFNA; interferon alpha
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interferons
   K05414  IFNA; interferon alpha
Other DBs
GO: 0005132
Genes
HSA: 3439(IFNA1) 3440(IFNA2) 3441(IFNA4) 3442(IFNA5) 3443(IFNA6) 3444(IFNA7) 3445(IFNA8) 3446(IFNA10) 3447(IFNA13) 3448(IFNA14) 3449(IFNA16) 3451(IFNA17) 3452(IFNA21)
PTR: 473185(IFNA21) 473191 473193(IFNA14) 473195(IFNA5) 473196(IFNA6) 473197 473198(IFNA2) 473199(IFNA8) 741660 741747 741797 741978 742651 744748
PPS: 100967539 100968231 100969275 100969624 100970300 100970658 100971675(IFNA6) 100972005 100972354 100972691(IFNA8) 100973049 100995734 117981650 117981652
GGO: 101137870(IFNA21) 101138981 101139336 101139713 101140412 101141176(IFNA6) 101141543 101141916(IFNA2) 101142301(IFNA8) 101142673 115935827 115935829 115935831 115935832 115935833 115935834 134756937
PON: 100432153 100432532(IFNA8) 100432906(IFNA2) 100433301 100434036(IFNA6) 100434796 100435169 100438149 100438871 100439978(IFNA21) 100443523 100445711 100459543 112134962 134759750
PPYG: 129043459 129044025 129044032 129044045 129044048(IFNA2) 129044057(IFNA6) 129044058 129044062(IFNA8) 129044063 129044064 129044068 129044069(IFNA21) 129044073 129044074 129044156
NLE: 100594907 100595254(IFNA8) 100595585(IFNA2) 100595932 100596272(IFNA6) 100596946 100597288 100597620 100597957 100598307
HMH: 116458330 116458331 116458332 116458527 116458611 116458660
SSYN: 129490328 129490329 129490330(IFNA6) 129490331 129490333 129490334 129490335 129490336 129490337 129490338 129490339
MCC: 106992322 106995851(IFNA6) 114672663 114672664 694631 709559(IFNA13) 709755(IFNA8) 709948(IFNA2) 710487 710528 710568 710654(IFNA10) 710751 710848 711088 711252(IFNA21)
PCOQ: 105827001
MMU: 15962(Ifna1) 15964(Ifna11) 15965(Ifna2) 15967(Ifna4) 15968(Ifna5) 15969(Ifna6) 15970(Ifna7) 15972(Ifna9) 15974(Ifnab) 230396(Ifna13) 230398(Ifna16) 242517(Ifna15) 242519(Ifna12) 404549(Ifna14)
RNO: 100911527(Ifna4l1) 100912314 100912356 134487075 134487077 298205(Ifna4) 298210(Ifna5) 298213(Ifna2) 500491(Ifna16l1) 502959(Ifna1l1) 502961(Ifna4l2) 690894(Ifna1)
HGL: 101697163
FCA: 101081371 101088440 111557596 493648(IFNA8) 493653(IFNA7) 493840(IFNA5)
PTG: 102956750
SSC: 100152100(IFN-ALPHA-13) 100152504(IFN-ALPHA-15) 100153325 100153661 100153724(IFN-ALPHA-8) 100154938(IFN-ALPHA-17) 100156561(IFN-ALPHA-10) 100156936 100157352(IFN-ALPHA-1) 100157735(IFN-ALPHA-16) 100157766(IFN-ALPHA-9) 100303758(IFN-ALPHA-5) 100310806(IFN-ALPHAOMEGA) 100737904 397686(IFNA1)
MYB: 106724769
MYD: 102766079
MMYO: 118667586
PPAM: 129078455
HAI: 109374670
TOD: 119232539
SARA: 101549593
SETR: 126003615 126003784(IFNA6)
ETF: 101650862
OAA: 100075323(IFN3)
GGA: 100857744(IFNAL4) 100857947(IFNAL5) 100858177 100859032(IFNAL6) 101750245(IFNKL1) 396398(IFNA3) 768614(IFA3L)
MGP: 104915046
CJO: 107306162
NMEL: 110390131
CATA: 118253811
AFUL: 116500557
LSR: 110470691
SCAN: 103819513 115485133(IFNK)
OTC: 121333061
PRUF: 121363354
FAB: 101811547(IFNW1) 101815751
OMA: 130265253
PMAJ: 107215808
CCW: 104685212
CBRC: 103613130
ZLE: 135460180
ACHL: 103797348
SVG: 106863721
MMEA: 130573232
HRT: 120765752
SATI: 136373549
FPG: 101915699(IFNW1)
FCH: 102059593 114016448(IFNK)
CCRI: 104154797
NNT: 104411022
SHAB: 115600831(IFNK) 115619639
ACUN: 113490068 113490202(IFNK)
TALA: 104368839
ACHC: 115336480
AGEN: 126036597
GCL: 127027653
CSTI: 104555774
MNB: 103774794
DPUB: 104305721
AVIT: 104269528
PCRI: 104033504
PCAO: 104039528
AFOR: 103894835
GSTE: 104255408
CLV: 102092004
PLET: 104614046
EHS: 104517087
CMAC: 104478818
CUCA: 104063167
TEO: 104369870
ACAR: 104527107
RTD: 128902910
TGT: 104573472 104578601(IFNA7)
SCAM: 104145483(IFNB1) 104147423
PMUR: 107293819
CTIG: 120314223
TSR: 106542110
PMUA: 114588052(IFNK)
GJA: 107108155
MUO: 115481865
DRE: 100126803(ifnphi3) 360134(ifnphi1)
PTET: 122341354(ifnphi3) 122341864(ifnphi1)
OMC: 131537137(ifnphi1) 131537782(ifnphi3)
PPRM: 120490098(ifnphi3) 120490237(ifnphi1)
RKG: 130070297(ifnphi1) 130070313(ifnphi3)
MAMB: 125250057(ifnphi3) 125268605 125272663(ifnphi1)
CERY: 137010665(ifnphi1) 137010678(ifnphi3)
TROS: 130561720(ifnphi1) 130561905(ifnphi3)
TDW: 130425819(ifnphi1) 130426410(ifnphi3)
MANU: 129423862(ifnphi3) 129436390(ifnphi1) 129436392
EMAC: 134870800 134871102 134878662(ifnphi1)
ECRA: 117936743(ifnphi4) 117940493
ESP: 116670973
PPUG: 119212932 119212933 119220758(ifnphi1)
CLUM: 117734698(ifnphi1) 117748853 117748885(ifnphi4)
SCHU: 122867615 122867624 122869125(ifnphi1)
PRET: 108167267
CVG: 107092889
ALIM: 106535558
NWH: 119423813
POV: 109642673
HHIP: 117752524 117752526(ifnphi4) 117758149 117766140(ifnphi1)
SLAL: 111656186
SBIA: 133495998(ifnphi4) 133514304(ifnphi1)
PEE: 133414847(ifnphi1)
PTAO: 133466487(ifnphi1) 133469710(ifnphi4)
BPEC: 110154330
BSPL: 114846466
HOC: 132830747(ifnphi4) 132830748
 » show all
Reference
PMID:6157600
  Authors
Mantei N, Schwarzstein M, Streuli M, Panem S, Nagata S, Weissmann C
  Title
The nucleotide sequence of a cloned human leukocyte interferon cDNA.
  Journal
Gene 10:1-10 (1980)
DOI:10.1016/0378-1119(80)90137-7
  Sequence
[hsa:3439]
LinkDB

KEGG   ORTHOLOGY: K05415
Entry
K05415                      KO                                     
Symbol
IFNB
Name
interferon beta
Pathway
map04060  Cytokine-cytokine receptor interaction
map04151  PI3K-Akt signaling pathway
map04217  Necroptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04668  TNF signaling pathway
map04936  Alcoholic liver disease
map05131  Shigellosis
map05135  Yersinia infection
map05142  Chagas disease
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05415  IFNB; interferon beta
   04668 TNF signaling pathway
    K05415  IFNB; interferon beta
   04151 PI3K-Akt signaling pathway
    K05415  IFNB; interferon beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05415  IFNB; interferon beta
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K05415  IFNB; interferon beta
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04621 NOD-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04622 RIG-I-like receptor signaling pathway
    K05415  IFNB; interferon beta
   04623 Cytosolic DNA-sensing pathway
    K05415  IFNB; interferon beta
   04650 Natural killer cell mediated cytotoxicity
    K05415  IFNB; interferon beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05415  IFNB; interferon beta
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05415  IFNB; interferon beta
   05161 Hepatitis B
    K05415  IFNB; interferon beta
   05160 Hepatitis C
    K05415  IFNB; interferon beta
   05171 Coronavirus disease - COVID-19
    K05415  IFNB; interferon beta
   05164 Influenza A
    K05415  IFNB; interferon beta
   05162 Measles
    K05415  IFNB; interferon beta
   05168 Herpes simplex virus 1 infection
    K05415  IFNB; interferon beta
   05163 Human cytomegalovirus infection
    K05415  IFNB; interferon beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05415  IFNB; interferon beta
   05169 Epstein-Barr virus infection
    K05415  IFNB; interferon beta
   05165 Human papillomavirus infection
    K05415  IFNB; interferon beta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05415  IFNB; interferon beta
   05135 Yersinia infection
    K05415  IFNB; interferon beta
   05152 Tuberculosis
    K05415  IFNB; interferon beta
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K05415  IFNB; interferon beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05415  IFNB; interferon beta
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05415  IFNB; interferon beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05415  IFNB; interferon beta
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  Interferons
   K05415  IFNB; interferon beta
Other DBs
GO: 0005132
Genes
HSA: 3456(IFNB1)
PTR: 473183(IFNB1)
PPS: 100995851(IFNB1)
GGO: 101137136(IFNB1)
PON: 100441074(IFNB1)
PPYG: 129044486(IFNB1)
NLE: 100598986(IFNB1)
HMH: 116458843(IFNB1)
SSYN: 129490755(IFNB1)
MCC: 711414(IFNB1)
MCF: 102115670(IFNB1)
MTHB: 126937702
MNI: 105465886(IFNB1)
CSAB: 103219383(IFNB1)
CATY: 105584002(IFNB1)
PANU: 101024523(IFNB1)
TGE: 112608413(IFNB1)
MLEU: 105545746(IFNB1)
RRO: 104670295(IFNB1)
RBB: 108538565(IFNB1)
TFN: 117098642(IFNB1)
PTEH: 111526147(IFNB1)
CANG: 105503452(IFNB1)
CJC: 100388391(IFNB1)
SBQ: 101035681(IFNB1)
CIMI: 108296169(IFNB1)
ANAN: 105715622(IFNB1)
CSYR: 103260915(IFNB1)
MMUR: 105874210(IFNB1)
LCAT: 123646249(IFNB1)
PCOQ: 105827006(IFNB1)
OGA: 100959385(IFNB1)
MMU: 15977(Ifnb1)
MCAL: 110293791(Ifnb1)
MPAH: 110323346(Ifnb1)
RNO: 24481(Ifnb1)
MCOC: 116095400(Ifnb1)
ANU: 117709633(Ifnb1)
MUN: 110541303(Ifnb1)
CGE: 103160615(Ifnb1)
MAUA: 121144026(Ifnb1)
PROB: 127224840(Ifnb1)
PLEU: 114685139(Ifnb1)
MORG: 121447990(Ifnb1)
MFOT: 126510741
AAMP: 119816165(Ifnb1) 119817276
NGI: 103743951(Ifnb1) 103746144
HGL: 101699042(Ifnb1) 101723869
DORD: 105988975(Ifnb1)
DSP: 122118962(Ifnb1)
PLOP: 125352673(Ifnb1)
MMMA: 107156465 107156489(Ifnb1)
OCU: 100342931
OPI: 101533318(IFNB1)
TUP: 102493858(IFNB1)
CFA: 481558(IFNB1)
CLUD: 112650215(IFNB1)
VVP: 112921940(IFNB1)
VLG: 121494639(IFNB1)
NPO: 129494739(IFNB1)
AML: 100476556(IFNB1)
UMR: 103662150(IFNB1)
UAH: 113260295(IFNB1)
UAR: 123781031(IFNB1)
ELK: 111156577
LLV: 125083789
MPUF: 101679100(IFNB1)
MNP: 132025125(IFNB1)
MLK: 131813182(IFNB1)
NVS: 122916938(IFNB1)
ORO: 101374900(IFNB1)
EJU: 114212404(IFNB1)
ZCA: 113934419(IFNB1)
MLX: 117998994(IFNB1)
NSU: 110587130(IFNB1)
LWW: 102748842(IFNB1)
FCA: 493849(IFNB1)
PYU: 121034394
PCOO: 112849621(IFNB1)
PBG: 122474874(IFNB1)
PVIV: 125150775
LRUF: 124525672
PTG: 102960421(IFNB1)
PPAD: 109247124(IFNB1)
PUC: 125925944
AJU: 106971145
HHV: 120239877(IFNB1)
SSC: 445459(IFNB1)
CFR: 102513411(IFNB1)
CBAI: 105061881(IFNB1)
CDK: 105095933(IFNB1)
VPC: 102540243(IFNB1)
BACU: 103011926
BMUS: 118897323(IFNB1)
LVE: 103073772
OOR: 101289058(IFNB1)
DLE: 111174560(IFNB1)
PCAD: 102990155(IFNB1)
PSIU: 116755914(IFNB1)
NASI: 112407026(IFNB1)
MYB: 102261905(IFNB1)
MYD: 102765800(IFNB1)
MMYO: 118666805(IFNB1)
MLF: 102417209(IFNB1)
MDT: 132212752(IFNB1)
PKL: 118716770(IFNB1)
EFUS: 103289195(IFNB1)
MNA: 107531433(IFNB1)
DRO: 112300024(IFNB1)
AJM: 119055662(IFNB1)
PDIC: 114512515(IFNB1)
PHAS: 123820149 123820232(IFNB1)
MMF: 118629329(IFNB1)
PPAM: 129078454(IFNB1)
HAI: 109396418(IFNB1)
RFQ: 117032413(IFNB1)
PALE: 102890512(IFNB1)
PGIG: 120605473(IFNB1)
PVP: 105309141(IFNB1)
RAY: 107518589(IFNB1)
MJV: 108402531(IFNB1)
TOD: 119231101(IFNB1)
SARA: 101548268(IFNB1)
SETR: 126002675(IFNB1)
LAV: 100666438(IFNB1)
TMU: 101349610
ETF: 101650550(IFNB1)
DNM: 101410923(IFNB1)
MDO: 100021258(IFNB1)
GAS: 123250431
SHR: 100914443
AFZ: 127552925
OAA: 100082925(IFNB1)
GGA: 554219(IFNW1)
MGP: 109363864
TPAI: 128074649
LMUT: 125687310
NMEL: 110390553
LSR: 110484216
SCAN: 108962800
OTC: 121345277
CBRC: 108449705
ZAB: 102066024
ACHL: 103802741
SVG: 106865001
FPG: 101921672
NNT: 104400091
TALA: 122153561
HLE: 104827847
LDI: 104350945
MNB: 103781025
NNI: 104017595
PCAO: 104050721
AFOR: 109279355
FGA: 104078379
MUI: 104542485
EHS: 104511443
CMAC: 104475033
CUCA: 128850512
ACAR: 104520009
CVF: 104287685
RTD: 128902806
AROW: 112976152
SCAM: 104152576
TVC: 132837626
 » show all
Reference
  Authors
Ohno S, Taniguchi T
  Title
Structure of a chromosomal gene for human interferon beta.
  Journal
Proc Natl Acad Sci U S A 78:5305-9 (1981)
DOI:10.1073/pnas.78.9.5305
  Sequence
[hsa:3456]
LinkDB

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