KEGG   ORTHOLOGY: K05556
Entry
K05556                      KO                                     
Symbol
actVI1, RED1
Name
ketoreductase RED1 [EC:1.1.1.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Reaction
R09306  
R09307  
R09308  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K05556  actVI1, RED1; ketoreductase RED1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K05556  actVI1, RED1; ketoreductase RED1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Ketoreductase
   K05556  actVI1, RED1; ketoreductase RED1
Genes
PROT: BTA34_00240
PAPP: QQS39_01725
MBAH: HYN46_09100
BSAV: WS86_30495
BUI: AX768_31340
PHS: C2L64_39925
PBRY: NDK50_20475
BEL: BE61_87580
BQB: J4P68_0017470
BBRA: QA636_38905
VGO: GJW-30_1_03969(lcdH_3)
SNOS: K8P63_09415
BOU: I5818_14265
PAEK: D3873_11650
PANC: E2636_01580
MSA: Mycsm_04371
MAB: MAB_0761c
MMV: MYCMA_0403
MABB: MASS_0730
MABL: MMASJCM_0753
MCHE: BB28_03670
MIZ: BAB75_04465
MSTE: MSTE_00722
CGLU: I6J20_06205
CAUI: CAURIS_09515(lcdH)
CBOV: CBOVI_00335(lcdH)
WHR: OG579_19405
GAM: GII34_16830
GOI: LK459_21015
TSM: ASU32_05195
TPUL: TPB0596_34320
SCO: SCO5072(SCBAC20F6.15)
SMA: SAVERM_1348(fadC7)
SGRF: SGFS_016200
SLV: SLIV_13025
STRE: GZL_01083 GZL_08371
STSI: A4E84_21345
SLS: SLINC_8479
SALJ: SMD11_6827
SLX: SLAV_40105(lcdH)
STRO: STRMOE7_32470
SGE: DWG14_01130(lcdH)
SDX: C4B68_38785
SCYA: EJ357_29890
SHAW: CEB94_21480
SRK: FGW37_16245
SVR: CP971_02435
SSEO: D0Z67_26995
SBY: H7H31_14990
SCOE: CP976_23040
SBRO: GQF42_35900 GQF42_41285
SDW: K7C20_31695
SMOB: J7W19_28340
SANU: K7396_05740
SGOB: test1122_15595
SDEC: L3078_44050
STAA: LDH80_09625
SNIG: HEK616_44430
SCAE: IHE65_44640
SENG: OJ254_26790
SYUN: MOV08_04310 MOV08_38835
SJN: RI060_37185
SOV: QZH56_04645 QZH56_16735 QZH56_23740
SHAU: K9S39_00230
SKG: KJK29_34475
SCOA: QU709_45695
KBU: Q4V64_27150
SCT: SCAT_p0753
SCY: SCATT_p09860
ARI: UM93_15795
BLY: A2T55_14490
BLIN: BLSMQ_3179
BRI: FDF13_06575
BLUT: EW640_07450
BCAU: I6G59_00375
BSPO: L1F31_14955
BREB: PGC08_15845
PRV: G7070_09010
FRA: Francci3_4139
FRI: FraEuI1c_1307
SEN: SACE_5408
AMD: AMED_6369
AMN: RAM_32655
AMM: AMES_6278
AMZ: B737_6278
AOI: AORI_2196
AJA: AJAP_28305
AMQ: AMETH_6178
AMYC: CU254_34485
AMYB: BKN51_03560
AMYY: YIM_22710(lcdH1)
AORI: SD37_11970
AACD: LWP59_35170
APRT: MUY14_04265
AROO: NQK81_11380
ATHM: L1857_33490
ARHD: VSH64_20690 VSH64_44780
AMOG: QRX60_48730
ACOR: LCL61_36850
PSEH: XF36_09650
KAL: KALB_2690
KUT: JJ691_45670
KPHY: AOZ06_28495
LED: BBK82_28455
CROS: N8J89_17320
MENO: Jiend_53070
ACAS: P7079_07350
AEY: CDG81_08720
FMR: Fuma_01191(lcdH)
CLAC: EG342_19995
 » show all
Reference
PMID:17579485
  Authors
Itoh T, Taguchi T, Kimberley MR, Booker-Milburn KI, Stephenson GR, Ebizuka Y, Ichinose K
  Title
Actinorhodin biosynthesis: structural requirements for post-PKS tailoring intermediates revealed by functional analysis of ActVI-ORF1 reductase.
  Journal
Biochemistry 46:8181-8 (2007)
DOI:10.1021/bi700190p
LinkDB

KEGG   ORTHOLOGY: K14626
Entry
K14626                      KO                                     
Symbol
actVIA
Name
actinorhodin biosynthesis protein ActVIA
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Reaction
R09308  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14626  actVIA; actinorhodin biosynthesis protein ActVIA
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14626  actVIA; actinorhodin biosynthesis protein ActVIA
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K14626  actVIA; actinorhodin biosynthesis protein ActVIA
Genes
NTC: KHQ06_29980
NYA: LTV02_09665
NGP: LTT66_26615
NSPU: IFM12276_10980
SCO: SCO5071(SCBAC20F6.14c)
SGRF: SGFS_016180
SLV: SLIV_13030
SVT: SVTN_18755
SRW: TUE45_01579
SPUN: BFF78_19365
SALJ: SMD11_1160
SCYA: EJ357_29885
SRK: FGW37_16285
SPLA: CP981_11565
SGOB: test1122_15650
STAA: LDH80_09615
SCYN: N8I84_12705
SOV: QZH56_16725 QZH56_23780
STTN: BSL84_25000
STPB: QR97_20360
SRPA: HEP86_12775
AGRA: AGRA3207_004552
FRA: Francci3_4104
PSDS: K1T35_37405
MENO: Jiend_53060
MCAY: PVK37_24365
AMS: AMIS_50520
DROS: Drose_24340
 » show all
Reference
PMID:7929165
  Authors
Fernandez-Moreno MA, Martinez E, Caballero JL, Ichinose K, Hopwood DA, Malpartida F
  Title
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).
  Journal
J Biol Chem 269:24854-63 (1994)
  Sequence
[sco:SCO5071]
Reference
PMID:17227452
  Authors
Taguchi T, Okamoto S, Lezhava A, Li A, Ochi K, Ebizuka Y, Ichinose K
  Title
Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis.
  Journal
FEMS Microbiol Lett 269:234-9 (2007)
DOI:10.1111/j.1574-6968.2007.00627.x
LinkDB

KEGG   ORTHOLOGY: K14627
Entry
K14627                      KO                                     
Symbol
actVI3
Name
dehydratase [EC:4.2.1.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Reaction
R09308  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14627  actVI3; dehydratase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14627  actVI3; dehydratase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K14627  actVI3; dehydratase
Genes
MYW: BVC93_11740
MNE: D174_01030
MYN: MyAD_01000
MHEV: MHEL_02930
MSAR: MSAR_46940
MPHU: MPHO_26770
MMUC: C1S78_004955
NBR: O3I_022830
NNO: NONO_c18340
NAD: NCTC11293_03432
NTC: KHQ06_10635 KHQ06_36845
NYA: LTV02_16430
NYU: D7D52_27210
SCO: SCO5074(SCBAC20F6.17)
SGRF: SGFS_016150
SLV: SLIV_13015
SVT: SVTN_18850
SPLU: LK06_031500
SCYA: EJ357_29900
SRK: FGW37_16230
SSPO: DDQ41_28830
SGOB: test1122_15685
KBU: Q4V64_27160
KFL: Kfla_1381
KQI: F1D05_26715
KSL: OG809_18475
KRI: OX958_29605
SEN: SACE_5375
AMD: AMED_6664
AMN: RAM_34190
AMM: AMES_6565
AMZ: B737_6565
AOI: AORI_2036
AJA: AJAP_29350
AMYC: CU254_26650
AMYB: BKN51_02340
AAB: A4R43_39490
AMYY: YIM_38365
AORI: SD37_30975
APRT: MUY14_03630
AROO: NQK81_12345
ARHD: VSH64_22725
AMOG: QRX60_50015
ACOR: LCL61_03425
APRE: CNX65_12160
AMI: Amir_2388
KAL: KALB_1674
KUT: JJ691_57570
KPHY: AOZ06_11905
LED: BBK82_04110
ALO: CRK55529
ACTU: Actkin_01423
CROS: N8J89_07420
SAQ: Sare_1524
CAI: Caci_6481
AEY: CDG81_08825
 » show all
Reference
PMID:7929165
  Authors
Fernandez-Moreno MA, Martinez E, Caballero JL, Ichinose K, Hopwood DA, Malpartida F
  Title
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).
  Journal
J Biol Chem 269:24854-63 (1994)
  Sequence
[sco:SCO5074]
LinkDB

KEGG   REACTION: R09308
Entry
R09308                      Reaction                               
Definition
(S)-Hemiketal <=> (S)-DNPA + H2O
Equation
C18356 <=> C12434 + C00001
Reaction class
RC02485  C12434_C18356
Enzyme
4.2.1.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00779  Dihydrokalafungin biosynthesis, octaketide => dihydrokalafungin
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-
     R09308  (S)-Hemiketal <=> (S)-DNPA + H2O
Orthology
K05556  ketoreductase RED1 [EC:1.1.1.-]
K14626  actinorhodin biosynthesis protein ActVIA
K14627  dehydratase [EC:4.2.1.-]
LinkDB

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