| Entry |
|
| Name |
methylglutaconyl-CoA hydratase;
methylglutaconyl coenzyme A hydratase;
3-methylglutaconyl CoA hydratase;
methylglutaconase;
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase
|
| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
|
| Sysname |
(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)
|
| Reaction(IUBMB) |
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O [RN: R02085]
|
| Reaction(KEGG) |
|
| Substrate |
(S)-3-hydroxy-3-methylglutaryl-CoA [CPD: C00356]
|
| Product |
|
| History |
EC 4.2.1.18 created 1961
|
| Pathway |
| ec00280 | Valine, leucine and isoleucine degradation |
|
| Orthology |
| K05607 | methylglutaconyl-CoA hydratase |
| K13766 | methylglutaconyl-CoA hydratase |
|
| Genes |
| PANU: | 101026404(AUH) 116268676 |
| CJC: | 100395264(AUH) 100395767 |
| MORG: | 121444487 121453331 |
| NCAR: | 124965512 124989221 |
| ORO: | 101371798 101372607(AUH) |
| PBG: | 122475241(AUH) 122480665 |
| PVIV: | 125150663(AUH) 125151635 |
| LRUF: | 124507903 124527793 |
| BTAX: | 128052404(AUH) 128066841 |
| CSUM: | 138079311 138081134(AUH) |
| OOR: | 101282650(AUH) 101288536 |
| LALB: | 132523825(AUH) 132530413 |
| DDP: | 132427521(AUH) 132437408 |
| DLE: | 111163642 111167650(AUH) |
| PSIU: | 116755425(AUH) 116763609 |
| PPHC: | 136124593(AUH) 136132212 |
| NASI: | 112390843(AUH) 112401269 |
| DRO: | 112307258(AUH) 112309148 |
| OMA: | 130265464(AUH) 130266672 |
| CTIG: | 120317423 120318636(AUH) |
| XLA: | 495229 734576(auh.S) |
| GRF: | 141299357 141299487(auh) |
| MZE: | 101474898(auh) 112429671 143415589 143416645 |
| ONL: | 100697484 100700973 102078228 |
| OAU: | 116315832(auh) 120437804 120438486 |
| PMEI: | 106911020 106912067 |
| PSPA: | 121302193 121315703 |
| ARUT: | 117400854 117409112 |
| SKO: | 100373940 102807162 102807299 |
| DSI: | Dsimw501_GD25824(Dsim_GD25824) |
| BCOO: | 119066783 119068994 |
| PPYR: | 116177613 116179652 |
| CFEL: | 113364013 113364016 |
| CBR: | CBG_23911(Cbr-ech-5) |
| BARL: | 143284577 143299469 |
| MFOO: | 138010972 138010973 |
| SPIS: | 111319094 111346928 |
| CSAT: | 104718676 104723421 104731900 |
| MINC: | 123210136 123210138 |
| AHF: | 112695317 112722296 112747780 112800365 |
| PCIN: | 129311857 129322144 |
| AANS: | 126793674 126794543 |
| PAVI: | 110756427 110756447 |
| CMAX: | 111465075 111498438 |
| CMOS: | 111431086 111453816 |
| CPEP: | 111801090 111809612 |
| PALZ: | 118039160 118062903 |
| CANN: | 107868222 107876127 |
| SSPL: | 121766779 121801554 |
| PEBU: | 140807359 140807711 |
| CARB: | 113703045 113705621 |
| CSIN: | 114262621 114262622 114274138 114281304 114312972 |
| MING: | 122063390 122086970 |
| PSOM: | 113297143 113302534 |
| TAES: | 123137747 123144979 |
| MFLO: | 136462259 136477869 |
| PVIR: | 120656670 120711377 |
| SMO: | SELMODRAFT_125455 SELMODRAFT_232742 |
| CSL: | COCSUDRAFT_6243 COCSUDRAFT_67198 |
| YLI: | 2908832(YALI2_E00675g) |
| NTE: | NEUTE1DRAFT85151(NEUTE1DRAFT_85151) |
| SMP: | 10803136(SMAC4_05937) |
| RTHE: | 98127358(VTJ83DRAFT_6046) |
| FPU: | FPSE_04239 FPSE_08118 |
| FVN: | FVRRES_00079 FVRRES_09675 |
| FVR: | FVEG_04720 FVEG_14162 |
| FKR: | NCS57_00338400 NCS57_00582300 |
| TATV: | 25784033(TrAtP1_008349) |
| TASP: | 36610074(TrAFT101_003047) |
| MAW: | 19251743(J3458_018890) |
| UVI: | 66068160(UV8b_07383) |
| PLJ: | 28884307(PLICBS_005571) |
| CDET: | 87940176(CDEST_03673) |
| PPSF: | 300792838(PFLUO_LOCUS6748) |
| CPW: | 9694059(D8B26_003190) |
| PTRR: | 6344481(PtrM4_046880) |
| ADAC: | 96080878(ACET3X_000556) |
| CDEC: | 89990150(IAS62_003378) |
| CTEG: | 91989480(I308_102624) |
| CBAS: | 91982784(I312_102737) |
| CDEP: | 91087814(L203_103603) |
| KMG: | 30166176(I203_104059) |
| KNE: | 92178979(IAR55_001720) |
| KDJ: | 28968081(I303_104638) |
| KBI: | 30209552(I302_106029) |
| KPIN: | 30172790(I206_104005) |
| KSH: | 87955535(IL334_003404) |
| KER: | 91099888(V865_001084) |
| KEP: | 91094837(L201_004167) |
| CCAC: | CcaHIS019_0701240(CcaverHIS019_0701240) |
| SHS: | STEHIDRAFT_76830 STEHIDRAFT_93579 |
| RSX: | RhiXN_01538 RhiXN_03861 |
| LBC: | LACBIDRAFT_245955(ECH-4) |
| ABP: | AGABI1DRAFT113260(AGABI1DRAFT_113260) |
| ABV: | AGABI2DRAFT192096(AGABI2DRAFT_192096) |
| MRR: | Moror_16857 Moror_8108 |
| MORE: | E1B28_004150 E1B28_004818 |
| SCM: | SCHCO_01085193(SCHCODRAFT_01085193) SCHCO_02623103(SCHCODRAFT_02623103) |
| UMA: | UMAG_01433 UMAG_01935 |
| SGRA: | EX895_001894 EX895_004025 |
| LMAT: | 92510943(LSCM1_00793) |
| LOI: | 92357211(LSCM4_01215) |
| LEIS: | 94176441(GH5_00806) |
| LENR: | 94168084(CUR178_00796) |
| LEIN: | 94184562(JIQ42_00802) |
| PHET: | 94287164(JKF63_01038) |
| XPH: | XppCFBP6546_20065(XppCFBP6546P_20065) |
| XHD: | LMG31886_24520(paaF) |
| VPB: | VPBB_A0562 VPBB_A1030 |
| VPK: | M636_02295 M636_05020 |
| VPF: | M634_20915 M634_23465 |
| VPH: | VPUCM_20551 VPUCM_21027 |
| VEX: | VEA_000379 VEA_001541 |
| VDB: | AL552_00110 AL552_05975 |
| VNA: | PN96_19030 PN96_21485 |
| VEJ: | VEJY3_18531 VEJY3_20636 |
| VNL: | D3H41_17140 D3H41_19530 |
| VJP: | NP165_14490 NP165_19160 |
| VIB: | VspSTUT11_39960 VspSTUT11_44730 |
| VIS: | VspSTUT16_34020 VspSTUT16_45820 |
| VID: | DBX26_15805 DBX26_17915 |
| VIP: | H9L11_20030 H9L11_22265 |
| VII: | ACHFJ9_00025 ACHFJ9_02200 |
| PAEB: | NCGM1900_4474(gnyH) |
| PAEU: | BN889_02191(liuC_1) |
| PMOL: | CLJ08_03600 CLJ08_20730 |
| PMOS: | O165_003885 O165_005040 |
| PMUD: | NCTC8068_03122(liuC) |
| PFW: | PF1751_v1c33250(liuC) |
| PSEC: | CCOS191_3463 CCOS191_3736 |
| PSET: | THL1_3225 THL1_5569 |
| PTAE: | NCTC10697_03140(menB) |
| HPEG: | EAO82_08955 EAO82_13390 |
| KAK: | Kalk_02230 Kalk_08100 |
| ABB: | ABBFA_02090(echA8_3) |
| SCAA: | TUM17387_13400(liuC) |
| TVD: | SG34_003880 SG34_011670 |
| PSEN: | PNC201_09585(echA2) |
| SALH: | HMF8227_01311(liuC) |
| MYA: | MORIYA_0479 MORIYA_2637(liuC) |
| SNAN: | I6N98_01500 I6N98_12790 |
| ZAL: | AZF00_01805 AZF00_04100 |
| MICT: | FIU95_01600(paaF1) FIU95_11465(echA1) |
| MSPN: | M8T91_14255 M8T91_17045 |
| HJA: | BST95_14340 BST95_19140 |
| LLG: | 44548918_02056(echA8_3) |
| LJR: | NCTC11533_00708(echA8_1) |
| LCJ: | NCTC11976_01877(menB) |
| LWA: | SAMEA4504053_2020(echA8_3) |
| LSS: | NCTC12082_02856(echA8_2) |
| LADL: | NCTC12735_01378(echA8_2) |
| GAI: | IMCC3135_26610(echA8_4) |
| HAAZ: | HaloA020_32490(liuC) |
| HKA: | R5M92_06280 R5M92_11215 |
| ALCA: | ASALC70_04374(paaF_2) |
| AEL: | NCTC12917_01920(caiD_1) |
| VFF: | VITFI_CDS1588 VITFI_CDS2822 VITFI_CDS3430 |
| CCAH: | DWG20_10695 DWG20_14155 |
| CVC: | BKX93_19595 BKX93_22010 |
| CHRO: | CXB49_13535 CXB49_15670 |
| CHRI: | DK842_14210 DK842_16025 |
| CHRB: | DK843_19780 DK843_21555 |
| CRZ: | D1345_05280 D1345_15850 |
| CHRM: | FYK34_02055 FYK34_03915 |
| CHAE: | CH06BL_11370 CH06BL_11960 |
| CSUT: | U6115_16060 U6115_18140 |
| CHRU: | DXT74_19370 DXT74_19730 |
| VOX: | LCH97_00925 LCH97_02360 |
| AQL: | BXU06_01515 BXU06_05680 BXU06_09290 |
| RPJ: | N234_00685 N234_35735 |
| REH: | H16_A0179(h16_A0179) |
| BVI: | Bcep1808_3493 Bcep1808_5067 |
| BUR: | Bcep18194_B0425 Bcep18194_B1319 |
| BCM: | Bcenmc03_5034 Bcenmc03_5776 |
| BCH: | Bcen2424_4528 Bcen2424_5238 |
| BCEN: | DM39_5407 DM39_6119 |
| BCEW: | DM40_3094 DM40_4540 |
| BAC: | BamMC406_4421 BamMC406_5119 |
| BMJ: | BMULJ_04378(paaG) BMULJ_05048(paaG) |
| BMUL: | NP80_4488 NP80_5076 |
| BCED: | DM42_5550 DM42_6239 |
| BCEP: | APZ15_22660 APZ15_30460 |
| BPYR: | ABD05_23435 ABD05_27345 |
| BCON: | NL30_03630 NL30_15980 |
| BDF: | WI26_21655 WI26_24975 |
| BLAT: | WK25_25140 WK25_28050 |
| BTEI: | WS51_06150 WS51_09145 |
| BSEM: | WJ12_28455 WJ12_32195 |
| BPSL: | WS57_01960 WS57_05455 |
| BMEC: | WJ16_27305 WJ16_30685 |
| BSTG: | WT74_27645 WT74_31030 |
| BSTL: | BBJ41_21905 BBJ41_26090 |
| BANN: | JFN94_16390 JFN94_26535 |
| BARI: | NLX30_24980 NLX30_29595 |
| BAEN: | L3V59_22425 L3V59_26975 |
| BSER: | R0290_18840 R0290_27475 |
| BUQ: | AC233_22255 AC233_32485 |
| BUM: | AXG89_06595 AXG89_13795 |
| BURK: | DM992_23735 DM992_32065 |
| BURM: | GJG85_19575 GJG85_23290 |
| BURF: | Bsp3421_001397 Bsp3421_002178 |
| BUV: | FPJ27_12575 FPJ27_17615 |
| BXB: | DR64_5138 DR64_6283 DR64_7561 |
| PGP: | CUJ91_21275 CUJ91_25015 |
| PPAI: | E1956_26140 E1956_41920 |
| PLG: | NCTC10937_02511(fcbB1) |
| AXX: | ERS451415_02191(echA8_5) |
| BOZ: | DBV39_09325 DBV39_18940 |
| RLH: | MIZ03_2341 MIZ03_4546 |
| ACIP: | CBP36_09610 CBP36_16235 |
| ACIS: | CBP35_02685 CBP35_09320 |
| AANT: | HUK68_16925 HUK68_20615 |
| CENP: | M9799_06405 M9799_18235 |
| ADN: | Alide_2883 Alide_3799 |
| ADK: | Alide2_1633 Alide2_4145 |
| LIM: | L103DPR2_00023(menB) |
| LIH: | L63ED372_03184(menB) |
| LIMM: | LMORI2_07840 LMORI2_22420 |
| HYR: | BSY239_2722 BSY239_3618 |
| HPSE: | HPF_12900(echA9) HPF_21045(paaF4) |
| HTN: | KI616_03940 KI616_12840 |
| HYDA: | ABSY19_10815 ABSY19_21405 |
| BWN: | ACI3EV_01360 ACI3EV_03115 |
| SAQA: | OMP39_12475 OMP39_14395 |
| METP: | C1M51_06615 C1M51_13605 |
| RDP: | RD2015_4344 RD2015_4473 |
| ROI: | N4261_23155 N4261_24480 |
| KIA: | G8A07_23945 G8A07_25010 |
| PKT: | AT984_15690 AT984_16130 |
| PAQA: | K9V56_008400 K9V56_020520 |
| PAIS: | PFX98_03295 PFX98_04355 |
| ROG: | ACQZ13_26285 ACQZ13_26885 |
| ROJ: | ACO228_15880 ACO228_22050 |
| SNN: | EWH46_00470 EWH46_09890 |
| JAJ: | EKL02_00480 EKL02_06190 |
| HSE: | Hsero_0823 Hsero_3076(caiD) |
| TMJ: | P0M04_09485 P0M04_30570 |
| THI: | THI_0465 THI_3270 THI_3562 |
| OTR: | OTERR_01880(liuC) OTERR_30280(liuC) |
| QAU: | KI612_00390 KI612_07155 |
| AHV: | AADV58_01070 AADV58_15470 |
| TMZ: | Tmz1t_0750 Tmz1t_1507 |
| THK: | CCZ27_16560 CCZ27_17925 |
| THAG: | CKCBHOJB_01109(echA8_3) CKCBHOJB_03194(echA8_5) |
| SMEL: | SM2011_b21126(eccH2) |
| SHIN: | LHJ69_00810 LHJ69_01770 |
| BMZ: | BM28_A0014 BM28_A0015 |
| BMG: | BM590_A0014 BM590_A0015 |
| BMW: | BMNI_I0014 BMNI_I0015 |
| HMC: | HYPMC_0165 HYPMC_3379 |
| MEMC: | OGR47_04460 OGR47_15640 |
| AUB: | LXB15_06075 LXB15_15395 |
| CAUB: | AMEJIAPC_02226(menB) |
| BVY: | NCTC9239_02137(menB_2) |
| BREN: | KKHFBJBL_01032(menB) |
| TSV: | DSM104635_01415(fadB_1) |
| RFU: | ROLI_009430(echA8_1) |
| PHAE: | N1037_09345 N1037_18025 N1037_20095 |
| MALG: | MALG_02368 MALG_03725 |
| SUAM: | BOO69_06565 BOO69_21805 |
| SPSE: | SULPSESMR1_01874(echA8) SULPSESMR1_04095(echA8) |
| RMM: | ROSMUCSMR3_00239(echA8) |
| RID: | RIdsm_01864(echA6) RIdsm_02343(echA8_5) RIdsm_05449(echA8_11) |
| SAGU: | CDO87_18825 CDO87_24025 |
| SAGZ: | QNI11_12680 QNI11_26190 QNI11_26310 |
| SEOH: | ACMUJL_04555 ACMUJL_19010 |
| PMAU: | CP157_01592(echA8_1) |
| DAA: | AKL17_2327 AKL17_3p0025 AKL17_4453 |
| LVS: | LOKVESSMR4R_01809(menB) |
| MANH: | LA6_003559(echA8_4) |
| SHUM: | STHU_34510 STHU_44410 |
| SVC: | STVA_17150 STVA_46170 |
| STEL: | STAQ_04620 STAQ_09850 |
| MGY: | MGMSRv2__0137 MGMSRv2__0407 |
| MGRY: | MSR1_01480(menB) MSR1_18070(paaF_1) |
| MAGX: | XM1_2265 XM1_4685(caiD) XM1_4764 |
| MAGN: | WV31_02465 WV31_02750 |
| NACI: | NUH88_04235 NUH88_20495 |
| THAR: | T8K17_00340 T8K17_23185 |
| BSTO: | C0V70_02635 C0V70_08250 |
| MFF: | MFFC18_09960(echA8) MFFC18_45470(caiD) |
| ROL: | CA51_12710(echA8_1) CA51_36910(echA8_2) |
| RUV: | EC9_19580(echA8_1) EC9_38230(echA8_2) |
| RCF: | Poly24_12450(paaF) Poly24_37060(echA8) |
| LCRE: | Pla8534_27960(echA8_1) |
| SMAM: | Mal15_56620(echA8_2) |
| AMUC: | Pan181_40270(echA8) |
| AGV: | OJF2_15620(paaF) OJF2_40820(echA8) |
| ABAC: | LuPra_04311(paaF_1) |
| SDJ: | NCTC13534_05627(menB) |
| DOR: | Desor_1410 Desor_4204 |
| MAUU: | NCTC10437_01633(pksH) |
| MSAG: | GCM10017556_56990(eccH2) |
» show all
|
| Reference |
|
| Authors |
HILZ H, KNAPPE J, RINGELMANN E, LYNEN F. |
| Title |
[Methylglutaconase, a new hydrase participating in the metabolism of various carboxylic acids.] |
| Journal |
Biochem Z 329:476-89 (1958) |
| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.1.18 |
| ExPASy - ENZYME nomenclature database: | 4.2.1.18 |
|
| LinkDB |
|