KEGG   ORTHOLOGY: K05711
Entry
K05711                      KO                                     
Symbol
hcaB
Name
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87]
Pathway
map00360  Phenylalanine metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA
Reaction
R06784  3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
R06785  (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K05711  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.87  3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
     K05711  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K05711
Other DBs
COG: COG1028
GO: 0018498
Genes
ECO: b2541(hcaB)
ECJ: JW2525(hcaB)
ECD: ECDH10B_2708(hcaB)
EBW: BWG_2305(hcaB)
ECOK: ECMDS42_2085(hcaB)
ECOC: C3026_14075
ECE: Z3813(hcaB)
ECS: ECs_3407(hcaB)
ECF: ECH74115_3773(hcaB)
ETW: ECSP_3485(hcaB)
ELX: CDCO157_3174
EOI: ECO111_3265(hcaB)
EOJ: ECO26_3588(hcaB)
EOH: ECO103_3061(hcaB)
ESL: O3K_06710
ESO: O3O_18940
ESM: O3M_06755
ECK: EC55989_2827(hcaB)
EOK: G2583_3071(hcaB)
ELR: ECO55CA74_15200
ELH: ETEC_2698
ECW: EcE24377A_2826(hcaB)
EUN: UMNK88_3194
ECOA: APECO78_16435
ECX: EcHS_A2693(hcaB)
ECM: EcSMS35_2694(hcaB)
ECY: ECSE_2828
ECR: ECIAI1_2593(hcaB)
EUM: ECUMN_2861(hcaB)
ECT: ECIAI39_2742(hcaB)
EOC: CE10_2973(hcaB)
EBR: ECB_02433(hcaB)
ECOB: C3029_16795
EBL: ECD_02433(hcaB)
EBE: B21_02397(hcaB)
EBD: ECBD_1143
ELO: EC042_2745(hcaB)
ECL: EcolC_1136
EKF: KO11_10115(hcaB)
EDH: EcDH1_1127
EDJ: ECDH1ME8569_2468(hcaB)
ELW: ECW_m2767(hcaB)
ELL: WFL_13550(hcaB)
ELP: P12B_c2641(hcaB)
ECOL: LY180_13035
ESZ: FEM44_02695(hcaB)
ESF: ACK8NJ_06110(hcaB)
SFL: SF2588(hcaB)
SFX: S2760(hcaB)
SFV: SFV_2589(hcaB)
SFE: SFxv_2844(hcaB)
SFN: SFy_3675
SFS: SFyv_3752
SFT: NCTC1_02844(hcaB)
SSN: SSON_2623(hcaB)
SBO: SBO_2565(hcaB)
SHQ: A0259_16430
SHIG: LXH19_06105(hcaB)
KPV: KPNIH29_19735
REE: electrica_01230(hcaB)
CFD: CFNIH1_24140
CWE: CO701_05125
CYO: CD187_06580
CPOT: FOB25_17725(hcaB)
CFQ: C2U38_18475
CIF: AL515_17225
CIE: AN232_10840
CPAR: CUC49_13150
CITZ: E4Z61_23080(hcaB)
CARS: E1B03_19725(hcaB)
CIX: M4I31_06390(hcaB)
CIB: HF677_006310(hcaB)
CITR: GUC46_06295(hcaB)
KAS: KATP_11280(hcaB)
KLU: K7B04_23375(hcaB)
KCY: RIN60_06195(hcaB)
KGN: GY169_05930(hcaB)
PSGC: G163CM_01180(hcaB)
EBF: D782_1128
SFW: WN53_15155
SFG: AV650_10695
PLU: plu2207(hcaB)
PLUM: A4R40_11065
PAY: PAU_02354(hcaB)
PTT: VY86_20025
PAKH: B0X70_11380
PLUI: CE143_11295
LRI: NCTC12151_03200(hcaB)
VNA: PN96_06455
VEJ: VEJY3_06595
VFU: vfu_A01968
VID: DBX26_06760
PKM: PZ739_18220(hcaB)
ALC: OTEC02_08855
AEI: AOY20_01935
ASJ: AsACE_CH00361(hcaB)
ADV: DJ533_16915(hcaB)
ARJ: DOM24_01620
ATN: FM020_13940(hcaB)
ACHI: CDG60_03005
ALJ: G8D99_13365(hcaB)
AWG: GFH30_01750(hcaB)
ASHA: G8E00_02290(hcaB)
ATG: J4G44_04430(hcaB)
AVB: RYU24_27060(hcaB)
ABOU: ACBO_27660(hcaB)
ACIU: A3K93_01305
APOT: MZO21_10805(hcaB)
ATZ: M5E07_14150(hcaB)
ACIE: KIP84_08225(hcaB)
ACIG: BS636_03560
ATV: ABEF79_01900(hcaB)
ZOB: ACEVBK_16190(hcaB)
GBI: PG2T_08585
AQL: BXU06_16220
BDF: WI26_30265
BANN: JFN94_26745(hcaB)
PACP: FAZ97_23030(hcaB)
PPAI: E1956_24370(hcaB)
PHUN: U0042_13195(hcaB)
BOJ: CBF45_10080
AALN: Q3V95_01605(hcaB)
AFA: UZ73_04225
AFQ: AFA_13930
AAQU: D3M96_14790
AAMM: FE795_12885(hcaB)
ALCN: MID00_13025(hcaB)
KGY: EHF36_10480
DIH: G7047_02075(hcaB)
RBU: PG1C_04295
NHUM: PQ457_20565(hcaB)
SYB: TZ53_25060
SPHT: K426_22019
TRO: trd_A0926
MSA: Mycsm_01916 Mycsm_01932 Mycsm_01993
MGOR: H0P51_21145
MYW: BVC93_18890
MVA: Mvan_4412
MAB: MAB_4365c
CDR: CDHC03_1955(hcaB)
CAZ: CARG_03230
CII: CIMIT_11750
CMV: CMUST_15100(hcaB)
CRF: FRC0190_02113
CLIZ: G7Y31_11570
COK: COCCU_04445(bphB)
CPSL: KBP54_01730
CHIN: J5O04_05680
CFG: CFREI_11775(bphB)
CCAW: CCANI_11875(bphB)
CFEU: CFELI_14035(bphB)
CORN: BJP05_09125
NNO: NONO_c29070
RHWQ: HUN07_20115(hcaB)
REQ: REQ_35110
PSOW: ABI214_20515(hcaB)
SGRF: SGFS_032160
SCB: SCAB_2141(hcaB)
STSI: A4E84_36405
SGM: GCM10017557_80200(hcaB)
SPHV: F9278_45570
SAKB: K1J60_43925
SSEC: ABZO29_43100(hcaB)
MIO: AOA12_18575
ASUN: KG104_01765
NAE: BHE16_09205
BLAP: MVA48_02345
 » show all
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
  Sequence
[eco:b2541]
LinkDB

KEGG   ENZYME: 1.3.1.87
Entry
EC 1.3.1.87                 Enzyme                                 
Name
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
hcaB (gene name);
cis-dihydrodiol dehydrogenase;
2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+ [RN:R06784];
(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ [RN:R06785]
Reaction(KEGG)
R06784 R06785
Substrate
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate [CPD:C12622]
Product
3-(2,3-dihydroxyphenyl)propanoate [CPD:C04044];
NADH [CPD:C00004];
H+ [CPD:C00080];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Comment
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
History
EC 1.3.1.87 created 2011
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05711  2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Genes
ECO: b2541(hcaB)
ECJ: JW2525(hcaB)
ECD: ECDH10B_2708(hcaB)
EBW: BWG_2305(hcaB)
ECOK: ECMDS42_2085(hcaB)
ECOC: C3026_14075
ECE: Z3813(hcaB)
ECS: ECs_3407(hcaB)
ECF: ECH74115_3773(hcaB)
ETW: ECSP_3485(hcaB)
ELX: CDCO157_3174
EOI: ECO111_3265(hcaB)
EOJ: ECO26_3588(hcaB)
EOH: ECO103_3061(hcaB)
ESL: O3K_06710
ESO: O3O_18940
ESM: O3M_06755
ECK: EC55989_2827(hcaB)
EOK: G2583_3071(hcaB)
ELR: ECO55CA74_15200
ELH: ETEC_2698
ECW: EcE24377A_2826(hcaB)
EUN: UMNK88_3194
ECOA: APECO78_16435
ECX: EcHS_A2693(hcaB)
ECM: EcSMS35_2694(hcaB)
ECY: ECSE_2828
ECR: ECIAI1_2593(hcaB)
EUM: ECUMN_2861(hcaB)
ECT: ECIAI39_2742(hcaB)
EOC: CE10_2973(hcaB)
EBR: ECB_02433(hcaB)
ECOB: C3029_16795
EBL: ECD_02433(hcaB)
EBE: B21_02397(hcaB)
EBD: ECBD_1143
ELO: EC042_2745(hcaB)
ECL: EcolC_1136
EKF: KO11_10115(hcaB)
EDH: EcDH1_1127
EDJ: ECDH1ME8569_2468(hcaB)
ELW: ECW_m2767(hcaB)
ELL: WFL_13550(hcaB)
ELP: P12B_c2641(hcaB)
ECOL: LY180_13035
ESZ: FEM44_02695(hcaB)
ESF: ACK8NJ_06110(hcaB)
SFL: SF2588(hcaB)
SFX: S2760(hcaB)
SFV: SFV_2589(hcaB)
SFE: SFxv_2844(hcaB)
SFN: SFy_3675
SFS: SFyv_3752
SFT: NCTC1_02844(hcaB)
SSN: SSON_2623(hcaB)
SBO: SBO_2565(hcaB)
SHQ: A0259_16430
SHIG: LXH19_06105(hcaB)
KPV: KPNIH29_19735
REE: electrica_01230(hcaB)
CFD: CFNIH1_24140
CWE: CO701_05125
CYO: CD187_06580
CPOT: FOB25_17725(hcaB)
CFQ: C2U38_18475
CIF: AL515_17225
CIE: AN232_10840
CPAR: CUC49_13150
CITZ: E4Z61_23080(hcaB)
CARS: E1B03_19725(hcaB)
CIX: M4I31_06390(hcaB)
CIB: HF677_006310(hcaB)
CITR: GUC46_06295(hcaB)
KAS: KATP_11280(hcaB)
KLU: K7B04_23375(hcaB)
KCY: RIN60_06195(hcaB)
KGN: GY169_05930(hcaB)
PSGC: G163CM_01180(hcaB)
EBF: D782_1128
SFW: WN53_15155
SFG: AV650_10695
PLU: plu2207(hcaB)
PLUM: A4R40_11065
PAY: PAU_02354(hcaB)
PTT: VY86_20025
PAKH: B0X70_11380
PLUI: CE143_11295
LRI: NCTC12151_03200(hcaB)
VNA: PN96_06455
VEJ: VEJY3_06595
VFU: vfu_A01968
VID: DBX26_06760
PKM: PZ739_18220(hcaB)
ALC: OTEC02_08855
AEI: AOY20_01935
ASJ: AsACE_CH00361(hcaB)
ADV: DJ533_16915(hcaB)
ARJ: DOM24_01620
ATN: FM020_13940(hcaB)
ACHI: CDG60_03005
ALJ: G8D99_13365(hcaB)
AWG: GFH30_01750(hcaB)
ASHA: G8E00_02290(hcaB)
ATG: J4G44_04430(hcaB)
AVB: RYU24_27060(hcaB)
ABOU: ACBO_27660(hcaB)
ACIU: A3K93_01305
APOT: MZO21_10805(hcaB)
ATZ: M5E07_14150(hcaB)
ACIE: KIP84_08225(hcaB)
ACIG: BS636_03560
ATV: ABEF79_01900(hcaB)
ZOB: ACEVBK_16190(hcaB)
GBI: PG2T_08585
AQL: BXU06_16220
BDF: WI26_30265
BANN: JFN94_26745(hcaB)
PACP: FAZ97_23030(hcaB)
PPAI: E1956_24370(hcaB)
PHUN: U0042_13195(hcaB)
BOJ: CBF45_10080
AALN: Q3V95_01605(hcaB)
AFA: UZ73_04225
AFQ: AFA_13930
AAQU: D3M96_14790
AAMM: FE795_12885(hcaB)
ALCN: MID00_13025(hcaB)
KGY: EHF36_10480
DIH: G7047_02075(hcaB)
RBU: PG1C_04295
NHUM: PQ457_20565(hcaB)
SYB: TZ53_25060
SPHT: K426_22019
TRO: trd_A0926
MSA: Mycsm_01916 Mycsm_01932 Mycsm_01993
MGOR: H0P51_21145
MYW: BVC93_18890
MVA: Mvan_4412
MAB: MAB_4365c
CDR: CDHC03_1955(hcaB)
CAZ: CARG_03230
CII: CIMIT_11750
CMV: CMUST_15100(hcaB)
CRF: FRC0190_02113
CLIZ: G7Y31_11570
COK: COCCU_04445(bphB)
CPSL: KBP54_01730
CHIN: J5O04_05680
CFG: CFREI_11775(bphB)
CCAW: CCANI_11875(bphB)
CFEU: CFELI_14035(bphB)
CORN: BJP05_09125
NNO: NONO_c29070
RHWQ: HUN07_20115(hcaB)
REQ: REQ_35110
PSOW: ABI214_20515(hcaB)
SGRF: SGFS_032160
SCB: SCAB_2141(hcaB)
STSI: A4E84_36405
SGM: GCM10017557_80200(hcaB)
SPHV: F9278_45570
SAKB: K1J60_43925
SSEC: ABZO29_43100(hcaB)
MIO: AOA12_18575
ASUN: KG104_01765
NAE: BHE16_09205
BLAP: MVA48_02345
 » show all
Reference
1  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
  Sequence
[eco:b2541]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.87
IUBMB Enzyme Nomenclature: 1.3.1.87
ExPASy - ENZYME nomenclature database: 1.3.1.87
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.87
BRENDA, the Enzyme Database: 1.3.1.87
LinkDB

KEGG   REACTION: R06784
Entry
R06784                      Reaction                               
Name
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
Definition
cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol + NAD+ <=> 3-(2,3-Dihydroxyphenyl)propanoate + NADH + H+
Equation
C11588 + C00003 <=> C04044 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00534  C04044_C11588
Enzyme
1.3.1.87
Pathway
rn00360  Phenylalanine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.87
     R06784  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol + NAD+ <=> 3-(2,3-Dihydroxyphenyl)propanoate + NADH + H+
Orthology
K05711  2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87]
Other DBs
RHEA: 25065
LinkDB

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