KEGG ORTHOLOGY: K05736

ORTHOLOGY: K05736

Entry

K05736                      KO

Symbol

PAK5, PAK7

Name

p21-activated kinase 5 [EC:2.7.11.1]

Pathway

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04360

Axon guidance

map04510

Focal adhesion

map04517

IgSF CAM signaling

map04660

T cell receptor signaling pathway

map04810

Regulation of actin cytoskeleton

map05170

Human immunodeficiency virus 1 infection

map05211

Renal cell carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05736  PAK5, PAK7; p21-activated kinase 5
   04014 Ras signaling pathway
    K05736  PAK5, PAK7; p21-activated kinase 5
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    K05736  PAK5, PAK7; p21-activated kinase 5
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05736  PAK5, PAK7; p21-activated kinase 5
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05736  PAK5, PAK7; p21-activated kinase 5
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K05736  PAK5, PAK7; p21-activated kinase 5
  09158 Development and regeneration
   04360 Axon guidance
    K05736  PAK5, PAK7; p21-activated kinase 5
09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K05736  PAK5, PAK7; p21-activated kinase 5
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05736  PAK5, PAK7; p21-activated kinase 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05736  PAK5, PAK7; p21-activated kinase 5
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K05736  PAK5, PAK7; p21-activated kinase 5
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE20 family
   K05736  PAK5, PAK7; p21-activated kinase 5

Genes

HSA:	57144(PAK5)

PTR:	469876(PAK5)

PPS:	100979774(PAK5)

GGO:	101124352(PAK5)

PON:	100174593(PAK5)

PPYG:

129022031(PAK5)

NLE:	100579630(PAK5)

HMH:	116461211(PAK5)

SSYN:

129474734(PAK5)

MCC:	719458(PAK5)

MCF:	101926721(PAK5)

MTHB:

126929039

MNI:	105481528(PAK5)

CSAB:

103246560(PAK5)

CATY:

105582086(PAK7)

PANU:

101000409(PAK5)

TGE:	112632986(PAK5)

MLEU:

105552841(PAK7)

RRO:	104655775(PAK5)

RBB:	108527563(PAK5)

TFN:	117068468(PAK5)

PTEH:

111546512(PAK5)

CANG:

105516590(PAK7)

CJC:	100411048(PAK5)

SBQ:	101045496(PAK7)

CIMI:

108300962(PAK5)

ANAN:

105719373(PAK5)

CSYR:

103261220(PAK5)

MMUR:

105880042(PAK5)

LCAT:

123622277(PAK5)

ERUF:

138400838(PAK5)

PCOQ:

105806183(PAK7)

OGA:	100951027(PAK5)

MMU:	241656(Pak5)

MCAL:

110289454(Pak5)

MPAH:

110317761(Pak5)

RNO:	311450(Pak5)

MCOC:

116091004(Pak5)

ANU:	117704567(Pak5)

ASYL:

127684589(Pak5)

MUN:	110540522(Pak5)

CGE:	100770198(Pak5)

MAUA:

101835751(Pak5)

PROB:

127221388(Pak5)

PLEU:

114703664(Pak5)

PMAV:

102920636(Pak5)

MORG:

121460477(Pak5)

MFOT:

126496845

AAMP:

119815102(Pak5)

CNL:	130881301(Pak5)

NGI:	103729196(Pak5)

HGL:	101697197(Pak5)

CPOC:

100731594(Pak5)

CCAN:

109688863(Pak5)

DORD:

105981579(Pak7)

DSP:	122120469(Pak5)

DMER:

138816726(Pak5)

PLOP:

125352322(Pak5)

NCAR:

124977925

MMMA:

107160861(Pak5)

ITI:	101978265(Pak5)

OCU:

100340742

OPI:	101517756(PAK5)

OCZ:	121157172(PAK5)

TUP:	102474805(PAK5)

GVR:	103603905(PAK7)

CFA:	485772(PAK5)

CLUD:

112673605(PAK5)

VVP:	112930051(PAK5)

VLG:	121478386(PAK5)

NPO:	129496131(PAK5)

AML:	100481254(PAK5)

UMR:	103674429(PAK5)

UAH:	113258241(PAK5)

UAR:	123799754(PAK5)

ELK:

111141714

LLV:

125109723

MPUF:

101681141(PAK7)

MNP:	132021731(PAK5)

MLK:	131808081(PAK5)

NVS:	122916259(PAK5)

ORO:	101362594(PAK7)

EJU:	114216393(PAK5)

ZCA:	113938315(PAK5)

MLX:	118011242(PAK5)

NSU:	110579436(PAK5)

LWW:	102750909(PAK5)

FCA:	101091011(PAK5)

PYU:	121012482(PAK5)

PCOO:

112868968(PAK5)

PBG:	122496567(PAK5)

PVIV:

125162541(PAK5)

LRUF:

124504252

LGF:	123580497(PAK5)

AJU:

106976429

PTG:	102959873(PAK5)

PPAD:

109274718(PAK5)

PUC:

125935986

PLEZ:

122214960(PAK5)

HHV:	120226240(PAK5)

BTA:	513432(PAK5)

BOM:	102288324(PAK5)

BIU:	109567943(PAK5)

BBUB:

102414520(PAK5)

BKE:	129625269(PAK5)

BBIS:

104984481(PAK7)

CHX:	102181217(PAK5)

OAS:	101107882(PAK5)

BTAX:

128058601(PAK5)

CSUM:

138091668(PAK5)

ODA:	120869190(PAK5)

CCAD:

122448747(PAK5)

MREE:

136157760(PAK5)

OVR:	110147781(PAK5)

MBEZ:

129556249(PAK5)

SSC:	100152316(PAK5)

CFR:	102512936(PAK5)

CBAI:

105082994(PAK7)

CDK:	105101260(PAK5)

VPC:	102531142(PAK5)

BACU:

102999931(PAK5)

BMUS:

118880538(PAK5)

LVE:	103077706(PAK7)

OOR:	101271942(PAK5)

LALB:

132505273(PAK5)

GMF:	115861604(PAK5)

DDP:	132438633(PAK5)

DLE:	111165611(PAK5)

PCAD:

102996458(PAK5)

PSIU:

116740333(PAK5)

PPHC:

136134613(PAK5)

NASI:

112412521(PAK5)

ECB:	100051415(PAK5)

EPZ:	103559731(PAK5)

EAI:	106823207(PAK5)

MYB:	102240345(PAK5)

MYD:	102752532(PAK5)

MMYO:

118663735(PAK5)

MLF:	102443084(PAK5)

MDT:	132239362(PAK5)

MYUM:

139013698(PAK5)

PKL:	118707679(PAK5)

EFUS:

103285671(PAK5)

MNA:	107536364(PAK7)

DRO:	112303959(PAK5)

SHON:

118990866(PAK5)

AJM:	119042688(PAK5)

PDIC:

114507070(PAK5)

PHAS:

123815356(PAK5)

MMF:	118618536(PAK5)

PPAM:

129070859(PAK5)

HAI:	109378999(PAK5)

RFQ:	117016309(PAK5)

PALE:

102884535(PAK5)

PGIG:

120611912(PAK5)

PVP:	105299451(PAK5)

RAY:	107497004(PAK5)

MJV:	108394258(PAK5)

TOD:	119232641(PAK5)

SARA:

101546118(PAK7)

SFUM:

130030372(PAK5)

SETR:

126018108(PAK5)

LAV:	100666744(PAK5)

TMU:

101361889

ETF:	101646840(PAK5)

DNM:	101418095(PAK5)

MDO:	100033279(PAK5)

GAS:	123233372(PAK5)

SHR:	100932749(PAK5)

AFZ:

127548496

PCW:	110208060(PAK5) 110210302

TVP:	118844317(PAK5)

PBRV:

138151859(PAK5)

OAA:	100084350(PAK5)

TACU:

119932426(PAK5)

GGA:	416734(PAK5)

PCOC:

116231900(PAK5)

MGP:	100547824(PAK5)

CJO:	107310935(PAK5)

TPAI:

128087861(PAK5)

LMUT:

125690175(PAK5)

NMEL:

110395539(PAK5)

APLA:

101789812(PAK5)

AACU:

137853250(PAK5)

ACYG:

106036610(PAK5)

CATA:

118251177(PAK5)

AFUL:

116488332(PAK5)

TGU:	100224879(PAK5)

LSR:	110475843(PAK5)

SCAN:

103819231(PAK5)

PMOA:

120505970(PAK5)

OTC:	121342681(PAK5)

PRUF:

121357114(PAK5)

ATRC:

139595167(PAK5)

GFR:	102045516(PAK5)

FAB:	101810542(PAK5)

OMA:	130251917(PAK5)

PHI:	102100245(PAK7)

PMAJ:

107201333(PAK5)

CCAE:

111926462(PAK5)

CCW:	104691523(PAK5)

CBRC:

103622982(PAK5)

ACOE:

138107584(PAK5)

ETL:	114057360(PAK5)

ZAB:	102063069(PAK5)

ZLE:	135446191(PAK5)

SVG:	106865171(PAK7)

MMEA:

130583485(PAK5)

SATI:

136358581(PAK5)

CFAI:

136286357(PAK5)

CCIC:

134042264(PAK5)

FPG:	101917292(PAK5)

FCH:	102054246(PAK5)

CCRI:

104162134(PAK7)

NNT:	104405648(PAK7)

SHAB:

115609694(PAK5)

ACUN:

113478339(PAK5)

SURA:

141941537(PAK5)

TALA:

104365753(PAK5)

ACHC:

115344239(PAK5)

HALD:

104315654(PAK7)

HLE:	104836306(PAK7)

AGEN:

126038865

HHAR:

128140410(PAK5)

BBUT:

142034358(PAK5)

GCL:

127015062

CSTI:

104556098(PAK7)

LDI:	104348090(PAK7)

MNB:	103771949(PAK7)

DPUB:

104305966(PAK7)

PPUS:

135176776(PAK5)

AVIT:

104273821(PAK7)

BRHI:

104489881(PAK7)

EGZ:	104132996(PAK5)

NNI:	104022435(PAK7)

PCRI:

104028069(PAK7)

PCAO:

104048578(PAK7)

PADL:

103913122(PAK7)

AFOR:

103901614(PAK5)

FGA:	104077561(PAK7)

CBOR:

142081475(PAK5)

GSTE:

104262551(PAK7)

CBOY:

140650368(PAK5)

MAME:

142407845(PAK5)

CLV:	102098855(PAK5)

CNIC:

135986836(PAK5)

MUI:	104538305(PAK7)

PGUU:

104461628(PAK7)

PLET:

104627767(PAK7)

EHS:

104507994

CMAC:

104483008(PAK7)

CUCA:

104055377(PAK5)

TEO:	104377346(PAK7)

BREG:

104636741(PAK7)

GAME:

129205281(PAK5)

OHA:	104330718(PAK7)

CPEA:

104397200(PAK7)

CVF:	104287339(PAK7)

RTD:	128907022(PAK5)

CRID:

134513998(PAK5)

LMIC:

141740204(PAK5)

NARQ:

141466356(PAK5)

AAM:	106490395(PAK5)

AROW:

112965311(PAK5)

NPD:	112958967(PAK5)

TGT:	104571103(PAK7)

DNE:	112980061(PAK5)

SCAM:

104143468(PAK7)

ASN:	102376998(PAK5)

AMJ:	102558433(PAK5)

CPOO:

109319494(PAK5)

GGN:	109296715(PAK5)

PSS:	102456678(PAK5)

CIZ:	142010190(PAK5)

CMY:	102943132(PAK5)

CCAY:

125633379(PAK5)

LKP:	140909700(PAK5)

NDS:	141985485(PAK5)

DCC:	119853904(PAK5)

CPIC:

101953291(PAK5)

TST:	117874221(PAK5)

CABI:

116836500(PAK5)

MRV:	120401538(PAK5)

ACS:	100560563(pak5)

ASAO:

132781477(PAK5)

PVT:	110090819(PAK5)

SUND:

121918975(PAK5)

PBI:	103058150(PAK5)

PMUR:

107285367(PAK5)

CTIG:

120315296(PAK5)

TSR:	106542667(PAK7)

PGUT:

117674376(PAK5)

PCAE:

139309006(PAK5)

APRI:

131197400(PAK5)

PTEX:

113442639(PAK5)

NSS:	113412664(PAK5)

VKO:	123035800(PAK5)

PMUA:

114593660(PAK5)

PRAF:

128410019(PAK5)

ZVI:	118082493(PAK5)

HCG:	128340054(PAK5)

GJA:	107123895(PAK5)

STOW:

125435070(PAK5)

EMC:	129340605(PAK5)

XLA:	108716398(pak5.L) 108717760(pak5.S)

XTR:	100145129(pak5)

NPR:	108795532(PAK5)

RTEM:

120938049(PAK5)

ACAT:

141141005(PAK5)

PADS:

140329391(PAK5)

BBUF:

120998997(PAK5)

BGAR:

122934429(PAK5)

DTC:	141057300(PAK5)

PWL:	138295687(PAK5)

MUO:	115465672(PAK5)

GSH:	117357758(PAK5)

DRE:	405898(pak5)

SRX:	107712195 107731598

SANH:

107659820 107704394

SGH:	107557903 107564328(pak7)

CCAR:

109076449 109113709(pak5)

CAUA:

113068560 113077981 113082017

CGIB:

127938271 127984407

PTET:

122324324(pak5)

LROH:

127183356(pak5)

GRF:	141283760(pak5)

OMC:	131526695(pak5)

PPRM:

120492113(pak5)

MAMB:

125278653(pak5)

CIDE:

127501921

CERY:

137019291(pak5)

MASI:

127409626 127415733

TROS:

130565541(pak5)

TDW:	130434719(pak5)

MANU:

129429053(pak5)

PDAB:

135761092(pak5)

IPU:	108257526(pak5)

IFU:	128601577(pak5)

PHYP:

113545324(pak5)

SMEO:

124376733(pak5)

TFD:	113644746(pak5)

TVC:	132843281(pak5)

CGAR:

128515257(pak5)

NGRA:

132883770(pak5)

TRN:	134320707(pak5)

AMEX:

103023523(pak5)

CMAO:

118815571(pak5)

EEE:

113589839

CHAR:

105910664(pak5)

SPIL:

134097424(pak5)

ASAD:

121711837(pak5)

TRU:	101065597(pak5)

TFS:	130516015(pak5)

TNG:	GSTEN00020286G001

LCO:	104919803(pak5)

NCC:	104949786(pak7)

TBEN:

117498342(pak7)

CGOB:

115003653(pak5)

PGEO:

117439709(pak5)

GACU:

117554287(pak7)

EMAC:

134876468(pak5)

ELY:

117271123

EFO:	125897271(pak5)

PLEP:

121955138(pak5)

SLUC:

116057949(pak5)

ECRA:

117961883(pak7)

ESP:	116706251(pak5)

PFLV:

114573558(pak5)

GAT:	120807789(pak5)

AFB:	129107194(pak5)

CLUM:

117727318(pak7)

PSWI:

130202602(pak5)

CANA:

137785830(pak5)

CVE:	137871252(pak5)

MSAM:

119908438(pak5)

SCHU:

122863607(pak5)

EARM:

139301991(pak5)

CUD:	121521846(pak5)

SPUL:

138585004(pak5)

LMIX:

132985186(pak5)

HTC:	141801822(pak5)

ALAT:

119012385(pak5)

ASTR:

137613693(pak5)

PKLU:

139218307(pak5)

MZE:	101463583(pak5)

ONL:	100697856(pak5)

OAU:	116332257(pak5)

OLA:	101159788(pak5)

OML:	112157690(pak5)

CSAI:

133464886(pak5)

XMA:	102223306(pak5)

XCO:	114158365(pak5)

XHE:	116733805(pak5)

PRET:

103457878(pak5)

PFOR:

103133026(pak7)

PLAI:

106954536(pak7)

PMEI:

106927348(pak7)

GAF:	122825003(pak5)

PPRL:

129369015(pak5)

CVG:	107097299(pak7)

CTUL:

119784124(pak5)

GMU:	124882079(pak5)

NFU:	107378108(pak7)

KMR:	108231823(pak5)

ALIM:

106533843

NWH:	119418473(pak5)

AOCE:

111575575(pak5)

EJA:	138203574(pak5)

BFRE:

138631351(pak5)

MCEP:

124998847(pak5)

CSEM:

103381003(pak7)

POV:	109632382(pak5)

SSEN:

122783625(pak5)

SSOE:

131444129(pak5)

HHIP:

117758567(pak7)

HSP:	118099263(pak5)

PPLT:

128460235(pak5)

SMAU:

118289895(pak5)

LCF:	108896930(pak5)

SDU:	111216376(pak5)

SLAL:

111672671(pak5)

XGL:	120789141(pak5)

HCQ:	109523359(pak5)

SSCV:

125990541(pak5)

SBIA:

133496734(pak5)

PEE:	133416912(pak5)

PTAO:

133468258(pak5)

BPEC:

110168289(pak5)

ENY:	140354831(pak5)

MALB:

109962210(pak5)

BSPL:

114849426(pak5)

SJO:	128376752(pak5)

SSCO:

133997351(pak5)

TTY:	137169286(pak5)

SASA:

106571559 106608064

STRU:

115174486(pak5) 115198731

OTW:	112217822 112250569

OMY:	110522449 110529869

OGO:	123990992 123995280

ONE:	115107994 115123684 115140387

OKI:	109866423 109900967

OKE:	118377105 118398411

OMM:	135505711 135557800

OCLA:

139407294 139415356

SALP:

111954136 112069033

SNH:	120019508 120024481

SFON:

129817201 129825351

CCLU:

121548702 121552308

ELS:	105017523(pak5)

OEP:	134025173(pak5)

SFM:	108929398(pak5)

PKI:	111837469(pak5)

AANG:

118230677(pak5) 118234735

AROT:

135257726(pak5)

CCOG:

133128543(pak5) 133142258

LOC:	102699066(pak7)

PSPA:

121315925 121317050

ARUT:

117403291 117411121

PSEX:

120516690(pak5)

LCM:	102347021(PAK5)

CMK:	103186430(pak5) 103187528

RTP:	109914891(pak5)

CPLA:

122553087

CPUN:

140483308

HOC:

132819525

SCAU:

119971211(pak5)

LERI:

129699282(pak5)

HAKA:

140730612

PMRN:

116943176 116948422(PAK4)

LRJ:	133342402 133352744

CIN:

SCLV:

CLEP:

SPU:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG18582(mbt)

DER:

6549994

DSE:

6617959

DSI:	Dsimw501_GD17288(Dsim_GD17288)

DYA:	Dyak_GE17281

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

CCAT:

BOD:

BDR:

RZE:	108370116 108380149

AOQ:

129236902

ALUD:

128859150 128859158

TDA:

119668205

MDE:	101893437 131802725

SCAC:

106087910

LCQ:

111674999

LSQ:

119601423

CVJ:	135957165(mbt)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004448

CPII:

CBRI:

CNS:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108725929(mbt)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139110994(Mbt)

TLN:	139808275(Mbt)

TAME:

143896386(Mbt)

HST:

DQU:

CFO:

FEX:

PMEC:

138943357(Mbt)

LHU:	105676520(mbt)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141536591(Mbt)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124221562(mbt)

NFB:

NLO:

NVG:

AROA:

SOY:

AGRG:

CSET:

AGB:

LDC:

APLN:

OTU:

CFEL:

CCRN:

ACOO:

DVT:

HHAL:

106691210(mbt)

NLU:	111060618 111063712

LDA:	142331221(mbt)

PHU:	Phum_PHUM392290

FOC:

113208590

PAME:

138701391(mbt)

BROR:

134527776

HAMR:

139688423(mbt)

FCD:

DMK:

DPZ:

AFRA:

PVM:	113822797(mbt)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123771016(mbt)

CQD:	128684881(mbt)

PTRU:

123499854

MNZ:

135204834

MRJ:	136856324(mbt)

PORN:

139762854(mbt)

HAZT:

108675187

EAF:

111716404

LSM:	121121299(mbt)

TCF:

131883945

DSV:

119457465

DALB:

135920781(mbt)

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

SDM:

LPOL:

HRO:	HELRODRAFT_94192

BARL:

HRF:

HRJ:

HASI:

HCRA:

CRG:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

RPHI:

DPOL:

MAEA:

SMM:	Smp_155140

OVI:	T265_10176

LLON:

ATEN:

MCAZ:

XEN:

HSY:

TAD:	TRIADDRAFT_20128

AQU:

100639104

» show all

Reference

PMID:18465753

Authors

Wu X, Carr HS, Dan I, Ruvolo PP, Frost JA

Title

p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.

Journal

J Cell Biochem 105:167-75 (2008)
DOI:10.1002/jcb.21809

Reference

PMID:14517284

Authors

Li X, Minden A

Title

Targeted disruption of the gene for the PAK5 kinase in mice.

Journal

Mol Cell Biol 23:7134-42 (2003)
DOI:10.1128/MCB.23.20.7134-7142.2003

Sequence

[mmu:241656]

LinkDB

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