KEGG   ORTHOLOGY: K05821
Entry
K05821                      KO                                     
Symbol
ARO9
Name
aromatic amino acid aminotransferase II [EC:2.6.1.58 2.6.1.28]
Pathway
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K05821  ARO9; aromatic amino acid aminotransferase II
   00360 Phenylalanine metabolism
    K05821  ARO9; aromatic amino acid aminotransferase II
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K05821  ARO9; aromatic amino acid aminotransferase II
  09110 Biosynthesis of other secondary metabolites
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K05821  ARO9; aromatic amino acid aminotransferase II
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K05821  ARO9; aromatic amino acid aminotransferase II
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.28  tryptophan---phenylpyruvate transaminase
     K05821  ARO9; aromatic amino acid aminotransferase II
    2.6.1.58  phenylalanine(histidine) transaminase
     K05821  ARO9; aromatic amino acid aminotransferase II
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Class I
   K05821  ARO9; aromatic amino acid aminotransferase II
Other DBs
RN: R00692 R00694 R00734 R09254
COG: COG1167
Genes
SCE: YHR137W(ARO9)
KLA: KLLA0_D11110g
KMX: KLMA_60423(ARO9)
LTH: KLTH0B06270g
VPO: Kpol_1035p30
ZRO: ZYRO0G05346g
CGR: CAGL0G06028g
NCS: NCAS_0B07220(NCAS0B07220)
NDI: NDAI_0B04550(NDAI0B04550)
TPF: TPHA_0O01520(TPHA0O01520)
TBL: TBLA_0B00990(TBLA0B00990)
TDL: TDEL_0F00900(TDEL0F00900)
PIC: PICST_34099(ARO9.1)
CAL: CAALFM_C405560CA(ARO9)
 » show all
Reference
PMID:9491083
  Authors
Iraqui I, Vissers S, Cartiaux M, Urrestarazu A
  Title
Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily.
  Journal
Mol Gen Genet 257:238-48 (1998)
DOI:10.1007/s004380050644
  Sequence
[sce:YHR137W]
LinkDB

KEGG   ENZYME: 2.6.1.58
Entry
EC 2.6.1.58                 Enzyme                                 
Name
phenylalanine(histidine) transaminase;
phenylalanine (histidine) aminotransferase;
phenylalanine(histidine):pyruvate aminotransferase;
histidine:pyruvate aminotransferase;
L-phenylalanine(L-histidine):pyruvate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-phenylalanine:pyruvate aminotransferase
Reaction(IUBMB)
L-phenylalanine + pyruvate = phenylpyruvate + L-alanine [RN:R00692]
Reaction(KEGG)
R00692;
(other) R09254
Substrate
L-phenylalanine [CPD:C00079];
pyruvate [CPD:C00022]
Product
phenylpyruvate [CPD:C00166];
L-alanine [CPD:C00041]
Comment
L-Histidine and L-tyrosine can act instead of L-phenylalanine; in the reverse reaction, L-methionine, L-serine and L-glutamine can replace L-alanine.
History
EC 2.6.1.58 created 1978
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05821  aromatic amino acid aminotransferase II
Genes
SCEYHR137W(ARO9)
KLAKLLA0_D11110g
KMXKLMA_60423(ARO9)
LTHKLTH0B06270g
VPOKpol_1035p30
ZROZYRO0G05346g
CGRCAGL0G06028g
NCSNCAS_0B07220(NCAS0B07220)
NDINDAI_0B04550(NDAI0B04550)
TPFTPHA_0O01520(TPHA0O01520)
TBLTBLA_0B00990(TBLA0B00990)
TDLTDEL_0F00900(TDEL0F00900)
TGBHG536_0G04140
ZMKHG535_0G00510
PPAPAS_chr1-3_0154 PAS_chr4_0147
PICPICST_34099(ARO9.1)
PGUPGUG_05380
LELLELG_05645
CALCAALFM_C405560CA(ARO9)
CTPCTRG_03861
COTCORT_0B00660
CDUCD36_45160
CTENCANTEDRAFT_120671
YLIYALI0C05258g
CLUCLUG_04493
CLUSA9F13_25g00781
CAURCJI97_003294
PKZC5L36_0E05810 C5L36_0E05820
BNNFOA43_004514
BBRXBRETT_003466
 » show all
Reference
1  [PMID:14070]
  Authors
Minatogawa Y, Noguchi T, Kido R.
  Title
Species distribution and properties of hepatic phenylalanine (histidine):pyruvate aminotransferase.
  Journal
Hoppe Seylers Z Physiol Chem 358:59-67 (1977)
DOI:10.1515/bchm2.1977.358.1.59
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.58
IUBMB Enzyme Nomenclature: 2.6.1.58
ExPASy - ENZYME nomenclature database: 2.6.1.58
BRENDA, the Enzyme Database: 2.6.1.58
CAS: 72560-98-6
LinkDB

KEGG   REACTION: R00692
Entry
R00692                      Reaction                               
Name
L-phenylalanine:pyruvate aminotransferase
Definition
L-Phenylalanine + Pyruvate <=> Phenylpyruvate + L-Alanine
Equation
Reaction class
RC00006  C00079_C00166
RC00008  C00022_C00041
Enzyme
Pathway
rn00360  Phenylalanine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K05821  aromatic amino acid aminotransferase II [EC:2.6.1.58 2.6.1.28]
Other DBs
RHEA: 13056
LinkDB

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