KEGG   ORTHOLOGY: K05824
Entry
K05824                      KO                                     
Symbol
LYS12
Name
homoisocitrate dehydrogenase [EC:1.1.1.87]
Pathway
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K05824  LYS12; homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K05824  LYS12; homoisocitrate dehydrogenase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K05824
Other DBs
RN: R01934 R01936 R04862
COG: COG0473
GO: 0047046
Genes
NLU: 120349269
QSU: 111984152 111991115
SCE: YIL094C(LYS12)
SEUB: DI49_2692
SPAO: SPAR_I00750
AGO: AGOS_ADL214C
ERC: Ecym_3326
KLA: KLLA0_E08339g
KMX: KLMA_80130(LYS12)
LTH: KLTH0G10384g
VPO: Kpol_1003p39
ZRO: ZYRO0A01914g
CGR: CAGL0G02585g
NCS: NCAS_0B06250(NCAS0B06250)
NDI: NDAI_0B03550(NDAI0B03550)
TPF: TPHA_0C03410(TPHA0C03410)
TBL: TBLA_0B05940(TBLA0B05940)
TGB: HG536_0A02300
TDL: TDEL_0G02180(TDEL0G02180)
KAF: KAFR_0J01360(KAFR0J01360)
KNG: KNAG_0A05420(KNAG0A05420)
ZMK: HG535_0D02020
PPA: PAS_chr2-2_0168
DHA: DEHA2C16852g
PIC: PICST_50442(LYS12)
PGU: PGUG_03875 PGUG_03876
SPAA: SPAPADRAFT_59913
LEL: LELG_00189
CAL: CAALFM_CR01400WA(LYS12)
CTP: CTRG_00945
COT: CORT_0A02990
CDU: CD36_26410
CTEN: CANTEDRAFT_112571
YLI: YALI0D10593g
CLUS: A9F13_04g01914
CAUR: CJI97_000756
SLB: AWJ20_5129(LYS12)
PKZ: C5L36_0C04140
BNN: FOA43_004130(LYS12)
BBRX: BRETT_002820(LYS12)
OPA: HPODL_04851
SLUD: SCDLUD_002757
NCR: NCU02954(lys-7)
NTE: NEUTE1DRAFT119171(NEUTE1DRAFT_119171)
SMP: SMAC_00496
PAN: PODANSg09901
TTT: THITE_2122134
MTM: MYCTH_2295290
CTHR: CTHT_0055150
MGR: MGG_01566
PPEI: PpBr36_01084
TMN: UCRPA7_5672
SSCK: SPSK_09424
FGR: FGSG_01392
FPU: FPSE_08564
FVR: FVEG_09468
FOX: FOXG_11323
TRE: TRIREDRAFT_23184
TRR: M419DRAFT_138813
MAW: MAC_01875
MAJ: MAA_00573
CMT: CCM_06018
PLJ: VFPFJ_08918
VAL: VDBG_03889
VDA: VDAG_01116
CFJ: CFIO01_06688
CLUP: CLUP02_14367
CHIG: CH63R_06308
SAPO: SAPIO_CDS4368
ELA: UCREL1_9930
PFY: PFICI_15112
SSL: SS1G_02537
BFU: BCIN_06g02300
MBE: MBM_09266
PSCO: LY89DRAFT_614007
GLZ: GLAREA_06943
ANI: AN5206.2
AFM: AFUA_6G07390
ACT: ACLA_081560
NFI: NFIA_053070
AOR: AO090005001561
ANG: ANI_1_398134(An15g02490)
AFV: AFLA_004390
ALUC: AKAW2_60443S(LYS12)
ACHE: ACHE_11370S(LYS12)
APUU: APUU_41359S(LYS12)
PCS: Pc18g05890
PDP: PDIP_70630
TMF: PMAA_057740
TRG: TRUGW13939_00840
CIM: CIMG_08027
CPW: CPC735_020650
URE: UREG_02316
PBL: PAAG_06387
PBN: PADG_01286
ABE: ARB_06194
TVE: TRV_01663
AJE: HCAG_07785
BGH: BDBG_09367
PNO: SNOG_01047
PTE: PTT_19273
BZE: COCCADRAFT_8727
BSC: COCSADRAFT_35926
BOR: COCMIDRAFT_8810
AALT: CC77DRAFT_1025667
ZTR: MYCGRDRAFT_85715
PFJ: MYCFIDRAFT_201320
FFU: CLAFUR5_02121
BCOM: BAUCODRAFT_73623
NPA: UCRNP2_9220
TML: GSTUM_00011274001
SPO: SPAC31G5.04
CNE: CND03850
CNB: CNBD2460
CNG: CNAG_01264
CGI: CGB_D6560C
TMS: TREMEDRAFT_37357
TASA: A1Q1_01965
TVS: TRAVEDRAFT_163469
DSQ: DICSQDRAFT_103251
PCO: PHACADRAFT_249972
SHS: STEHIDRAFT_77028
HIR: HETIRDRAFT_311764
PSQ: PUNSTDRAFT_112210
ADL: AURDEDRAFT_110590
FME: FOMMEDRAFT_169234
GTR: GLOTRDRAFT_109763
LBC: LACBIDRAFT_229977
CCI: CC1G_00055
ABP: AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: AGABI2DRAFT191701(AGABI2DRAFT_191701)
PCUB: JR316_0004687
MRR: Moror_17619
MORE: E1B28_004546
SCM: SCHCO_02623734(SCHCODRAFT_02623734)
CPUT: CONPUDRAFT_64839
SLA: SERLADRAFT_460541
WSE: WALSEDRAFT_60334
WIC: J056_003089
UMA: UMAG_04873
PFP: PFL1_04288
MGL: MGL_3003
MRT: MRET_3610
MSYM: MSY001_1272
MLR: MELLADRAFT_35949
ACAN: ACA1_255210
NGR: NAEGRDRAFT_79802
PFUW: KF707C_48470
PCQ: PcP3B5_09520(hicd)
PMUI: G4G71_07730
PNT: G5B91_27755
PDR: H681_20765
PKC: PKB_4900(leub3)
PSET: THL1_4856
PLAL: FXN65_23330
PNN: KEM63_14200
PPHA: BVH74_01680
HPEG: EAO82_05040
HAES: LO767_13135
HARR: HV822_11970
AQL: BXU06_12520
AMAH: DLM_3455
AQS: DKK66_09785
VOG: LCH97_15160
RRS: RoseRS_1057
RCA: Rcas_3471
CAU: Caur_0331
CHL: Chy400_0356
CAG: Cagg_3600
HAU: Haur_3304
ATM: ANT_08240
PSUB: Pelsub_P2051
LEK: hrd7_27880(hicd)
CAP: CLDAP_04830
PMET: G4Y79_23070
DRA: DR_1674
DGE: Dgeo_1458
DDR: Deide_09240
DMR: Deima_1545
DGO: DGo_CA1124
DPD: Deipe_3811
DSW: QR90_06130
DCH: SY84_04075
DAB: AUC44_04755
DPU: SU48_06750
DEZ: DKM44_12070
DWU: DVJ83_05910
DFC: DFI_05685
DEIN: DAAJ005_11775
DGA: DEGR_21420
DPH: EHF33_11670
DRB: N0D28_12770
DAH: DAETH_21930
DAQU: M8445_09600
TRA: Trad_2841
TTH: TT_C1012
TTJ: TTHA1378(TTHA1378)
TTS: Ththe16_1388
TTL: TtJL18_0670
TSC: TSC_c20650(icd2)
THC: TCCBUS3UF1_6370
TOS: Theos_0440
TAQ: TO73_0559
TPAR: AV541_03840
TBC: A0O31_01242
TANT: KNN15_01885
MRB: Mrub_2738
MRE: K649_08845
MTAI: Mtai_v1c23390
MSV: Mesil_1337
OPR: Ocepr_1387
MHD: Marky_1533
MEUZ: KRP56_05915
 » show all
Reference
PMID:4395693
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]
LinkDB

KEGG   ORTHOLOGY: K10978
Entry
K10978                      KO                                     
Symbol
aksF
Name
methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K10978  aksF; methanogen homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K10978  aksF; methanogen homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K10978  aksF; methanogen homoisocitrate dehydrogenase
    1.1.1.-
     K10978  aksF; methanogen homoisocitrate dehydrogenase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K10978
Other DBs
RN: R01934 R01936 R04862 R08214 R08215
COG: COG0473
Genes
SCOR: J3U87_19140
ARAM: KAR29_05995
MJA: MJ_1596
MFE: Mefer_0957
MVU: Metvu_0752
MFS: MFS40622_0058
MIF: Metin_0287
MJH: JH146_0764
MESG: MLAUSG7_1557(aksF)
MESA: MLASG1_1116(aksF)
MIG: Metig_0040
MMP: MMP0880(aksF)
MMQ: MmarC5_0688
MMX: MmarC6_1775
MMZ: MmarC7_0128
MMD: GYY_05110
MMAK: MMKA1_09750(aksF)
MMAO: MMOS7_09540(aksF)
MMAD: MMJJ_01120(hicd_1)
MAE: Maeo_1484
MVN: Mevan_0040
MVO: Mvol_0791
MOK: Metok_1293
METF: CFE53_02585
MTH: MTH_184
MMG: MTBMA_c06370
MWO: MWSIV6_0600(leuB1)
MTEE: MTTB_08450
METC: MTCT_0151
METE: tca_00168(hicd_1)
METZ: METMT2_0650
METK: FVF72_01360
MTHM: FZP57_02855
MST: Msp_0674
METB: AW729_04705
MRU: mru_1033(aksF)
MSI: Msm_0373
MEB: Abm4_0999(aksF)
MMIL: sm9_0644(aksF)
MEYE: TL18_03130
MOL: YLM1_0578
MARO: MarbSA_20290
METV: K4897_02380
MEL: Metbo_0581
MEW: MSWAN_1784
METH: MBMB1_1404(leuB1)
MFC: BRM9_0639(aksF)
MFI: DSM1535_0612(leuB1)
MCUB: MCBB_1645(leuB1)
MSUB: BK009_06025
METN: BK008_01565
METT: CIT01_09740
METO: CIT02_10965
MEME: HYG87_10135
MFV: Mfer_1273
MKA: MK1215(leuB_2)
MBA: Mbar_A0248
MBY: MSBRM_2706
MBW: MSBRW_0747
MBAR: MSBR2_2662
MBAK: MSBR3_2764
MAC: MA_3748(leuB)
MMA: MM_0642
MMAZ: MmTuc01_0657
MMJ: MSMAS_0667
MMAC: MSMAC_0669
MVC: MSVAZ_0686
MEK: MSKOL_0664
MLS: MSLAZ_2217
METM: MSMTP_0734
MEF: MSWH1_0829
MEQ: MSWHS_0888
MSJ: MSSAC_3556
MSZ: MSSIH_3098
MSW: MSSIT_3155
MTHR: MSTHT_2378
MTHE: MSTHC_0902
MHOR: MSHOH_0789
MFZ: AOB57_003530
MMET: MCMEM_2087
MELO: J7W08_09400
MMH: Mmah_0129
MHAZ: BHR79_02805
MEV: Metev_1314
MZH: Mzhil_1662
MPY: Mpsy_2352
MZI: HWN40_10585
MHZ: Metho_0479
MTP: Mthe_0855
MCJ: MCON_1920(aksF)
MHI: Mhar_2394
MHU: Mhun_1797
MRTJ: KHC33_05425
MLA: Mlab_0235
MEM: Memar_0637
MBG: BN140_3039(leuB3)
MEMA: MMAB1_2207(leuB)
MCHK: MchiMG62_07670
MSUM: OH143_09905
MPI: Mpet_2492
MEND: L6E24_09210
MAQE: RJ40_05965
MOU: OU421_03670
MBN: Mboo_0602
MFO: Metfor_2589
MPL: Mpal_2146
MPD: MCP_1963(aksF)
MEZ: Mtc_1557(aksF)
RCI: RCIX2644(leuB-2)
PTO: PTO0910
MEUZ: KRP56_01655
 » show all
Reference
PMID:10940051
  Authors
Howell DM, Graupner M, Xu H, White RH
  Title
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:5013-6 (2000)
DOI:10.1128/JB.182.17.5013-5016.2000
  Sequence
[mja:MJ_1596]
LinkDB

KEGG   ORTHOLOGY: K17753
Entry
K17753                      KO                                     
Symbol
HICDH
Name
isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Pathway
map00020  Citrate cycle (TCA cycle)
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.286  isocitrate---homoisocitrate dehydrogenase
     K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Other DBs
RN: R00709 R01934 R01936 R04862
COG: COG0473
GO: 0033708
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
Reference
PMID:15845397
  Authors
Miyazaki K
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]
LinkDB

KEGG   REACTION: R01934
Entry
R01934                      Reaction                               
Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Equation
C05662 + C00003 <=> C00322 + C00011 + C00004 + C00080
Comment
two-step reaction (see R04862+R01936), reversible
Reaction class
RC00001  C00003_C00004
RC00114  C00322_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Reference
1  [PMID:4395693]
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
Reference
2  [PMID:5808337]
  Authors
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM.
  Title
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis.
  Journal
Biochemistry 8:2846-55 (1969)
DOI:10.1021/bi00835a023
Other DBs
RHEA: 11903
LinkDB

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