KEGG   ORTHOLOGY: K05831
Entry
K05831                      KO                                     
Symbol
lysK, argE
Name
[amino group carrier protein]-lysine/ornithine hydrolase [EC:3.5.1.130 3.5.1.132]
Pathway
map00220  Arginine biosynthesis
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00031  Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine
M00763  Ornithine biosynthesis, mediated by LysW, glutamate => ornithine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K05831  lysK, argE; [amino group carrier protein]-lysine/ornithine hydrolase
   00220 Arginine biosynthesis
    K05831  lysK, argE; [amino group carrier protein]-lysine/ornithine hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.130  [amino group carrier protein]-lysine hydrolase
     K05831  lysK, argE; [amino group carrier protein]-lysine/ornithine hydrolase
    3.5.1.132  [amino group carrier protein]-ornithine hydrolase
     K05831  lysK, argE; [amino group carrier protein]-lysine/ornithine hydrolase
Other DBs
RN: R09779 R10933
COG: COG0624
Genes
MSD: MYSTI_01363
MFB: MFUL124B02_07570
CCX: COCOR_02071(lysK)
AVM: JQX13_36415
CTH: Cthe_2568
CTX: Clo1313_0154
GEK: kuro4_23300
SFA: Sfla_0118
STRP: F750_6906
SPAV: Spa2297_32330
SALJ: SMD11_6705
SESP: BN6_56690
CAI: Caci_6288
RCA: Rcas_3459
CAU: Caur_1204
CAG: Cagg_2180
HAU: Haur_3310
TRO: trd_1520
STI: Sthe_0214
ATM: ANT_12370(lysK)
CAP: CLDAP_41050(lysK)
TTR: Tter_0317
DRA: DR_1413
DGE: Dgeo_1391
DDR: Deide_17960(lysK)
DFC: DFI_03165
DGA: DEGR_27060(lysK)
TRA: Trad_1404
TTH: TT_C1396
TTJ: TTHA1757(TTHA1757)
TAQ: TO73_0259
MRB: Mrub_0027
TAI: Taci_0451
TLI: Tlie_1473
PFU: PF1686
PFI: PFC_10175
PHO: PH1715(PH1715)
PAB: PAB0294(argE)
PYN: PNA2_0325
PYS: Py04_1632
TKO: TK0274
THS: TES1_0511
HHB: Hhub_3652(argE)
HALH: HTSR_0668(argE)
HHSR: HSR6_0694(argE)
HSU: HLASF_2141(argE2)
HSF: HLASA_2175(argE2)
HARA: AArcS_3065(argE2)
HMA: rrnAC2674(gltCP)
HHI: HAH_3079(argE1)
NPH: NP_5266A(argE)
NMO: Nmlp_1239(argE)
HUT: Huta_1498
HTI: HTIA_1543
HMU: Hmuk_0776
HALL: LC1Hm_3292(argE3)
HDS: HSR122_1701(argE)
HWA: HQ_3718A(argE2)
HWC: Hqrw_4133(argE2)
HVO: HVO_0042(argE)
HME: HFX_0042(argE)
HLA: Hlac_2612
HDF: AArcSl_0039(argE)
HTU: Htur_0324
NMG: Nmag_1757(argE)
NAT: NJ7G_0259
SALI: L593_07905
PTO: PTO1468
FAI: FAD_0509(lysK)
CDIV: CPM_0544
APE: APE_1467.1(lysK)
ACJ: ACAM_0925(lysK)
IHO: Igni_0664
IIS: EYM_06525
IAG: Igag_1750
STO: STK_01900(lysK)
SSO: SSO0162
SOL: Ssol_1139
SSOA: SULA_1175
SSOL: SULB_1176
SSOF: SULC_1174
SCAS: SACC_00740
SAI: Saci_0756
SID: M164_1984
SII: LD85_2239
SIH: SiH_1922
SIR: SiRe_1849
SIC: SiL_1831
MSE: Msed_0170
MCN: Mcup_1903
AHO: Ahos_0889
ACIH: HS5_22640
CSTY: KN1_18110
STEP: IC006_1908
PAI: PAE2798
PIS: Pisl_1394
PCL: Pcal_1259
PAS: Pars_0867
PYR: P186_1739
POG: Pogu_1471
TNE: Tneu_1861
CMA: Cmaq_1676
TTN: TTX_0118(lysK_argE)
TUZ: TUZN_1280
VDI: Vdis_0199
VMO: VMUT_1537
NMR: Nmar_1296
NCT: NMSP_0392
NGA: Ngar_c14550(lysK)
NVN: NVIE_002650(lysK)
NEV: NTE_01581
TAA: NMY3_02229(dapE_2)
NFN: NFRAN_2991(dapE)
NCV: NCAV_1408
NBV: T478_1051
NDV: NDEV_1631
CCAI: NAS2_0273
KCR: Kcr_0814
BARB: AOA66_0023
 » show all
Reference
  Authors
Miyazaki J, Kobashi N, Fujii T, Nishiyama M, Yamane H
  Title
Characterization of a lysK gene as an argE homolog in Thermus thermophilus HB27.
  Journal
FEBS Lett 512:269-74 (2002)
DOI:10.1016/S0014-5793(02)02290-1
  Sequence
[tth:TT_C1396]
Reference
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
Reference
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_0756]
LinkDB

KEGG   ENZYME: 3.5.1.132
Entry
EC 3.5.1.132                Enzyme                                 
Name
[amino group carrier protein]-ornithine hydrolase;
lysK (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
[amino group carrier protein]-C-terminal-gamma-L-ornithyl-L-glutamate amidohydrolase
Reaction(IUBMB)
[amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-ornithine
Reaction(KEGG)
(other) R10933
Substrate
[amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate;
H2O [CPD:C00001]
Product
[amino group carrier protein]-C-terminal-L-glutamate;
L-ornithine [CPD:C00077]
Comment
The enzyme participates in an L-arginine biosynthetic pathways in certain species of archaea and bacteria. In all cases known so far the enzyme also catalyses the activity of EC 3.5.1.130, [amino group carrier protein]-lysine hydrolase.
History
EC 3.5.1.132 created 2019
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K05831  [amino group carrier protein]-lysine/ornithine hydrolase
Genes
MSDMYSTI_01363
MFBMFUL124B02_07570
CCXCOCOR_02071(lysK)
AVMJQX13_36415
CTHCthe_2568
CTXClo1313_0154
GEKkuro4_23300
SFASfla_0118
STRPF750_6906
SPAVSpa2297_32330
SALWCP975_34125
SALJSMD11_6705
SFICEIZ62_06130
KITCFP65_3951
SESPBN6_56690
SSYIEKG83_30595
PLKCIK06_18340
CAICaci_6288
RRSRoseRS_2723
RCARcas_3459
CAUCaur_1204
CHLChy400_1317
CAGCagg_2180
HAUHaur_3310
TROtrd_1520
STISthe_0214
ATMANT_12370(lysK)
PSUBPelsub_P1476
CAPCLDAP_41050(lysK)
THUGKNN16_06530
TTRTter_0317
PMETG4Y79_18415
DRADR_1413
DGEDgeo_1391
DDRDeide_17960(lysK)
DMRDeima_2593
DGODGo_CA0925
DPDDeipe_0519
DSWQR90_13875
DCHSY84_06565
DABAUC44_13595
DPUSU48_08310
DEZDKM44_04740
DWUDVJ83_04390
DFCDFI_03165
DEINDAAJ005_05770
DGADEGR_27060(lysK)
DPHEHF33_12145
TRATrad_1404
TTHTT_C1396
TTJTTHA1757(TTHA1757)
TTSThthe16_1773
TTLTtJL18_0288
TSCTSC_c03520
THCTCCBUS3UF1_19650
TOSTheos_2051
TAQTO73_0259
TBCA0O31_00749
TANTKNN15_06005
MRBMrub_0027
MREK649_07095
MSVMesil_0347
MTAIMtai_v1c00240
OPROcepr_1798
MHDMarky_0663
UAMUABAM_02293
TAITaci_0451
TLITlie_1473
AMOAnamo_0986
CPORBED41_13070
BFEK6V30_24250
PFUPF1686
PFIPFC_10175
PHOPH1715(PH1715)
PABPAB0294(argE)
PYNPNA2_0325
PYSPy04_1632
TKOTK0274
THSTES1_0511
THVADU37_CDS10090
TCHCHITON_1975
HDLHALDL1_01635
HHBHhub_3652(argE)
HNOLT974_00100
HLULT972_14160
HJEHacjB3_00970
HALHHTSR_0668(argE)
HHSRHSR6_0694(argE)
HSUHLASF_2141(argE2)
HSFHLASA_2175(argE2)
SALRFQU85_04715
HALREFA46_004280
HARAAArcS_3065(argE2)
HAADMW046_06585
HALXM0R89_05945
HMArrnAC2674(gltCP)
HHIHAH_3079(argE1)
HHNHISP_15675
HABSG26_07770
HTABVU17_14985
HALJG9465_02485
HSINKDQ40_13815
NPHNP_5266A(argE)
NMONmlp_1239(argE)
NHOHWV23_08490
NSALHWV07_10875
HUTHuta_1498
HTIHTIA_1543
HALAHrd1104_12275
HMUHmuk_0776
HALZE5139_07065
HALLLC1Hm_3292(argE3)
HAZPGBQ70_07060
HALIBV210_07095
HSNDV733_03375
HDSHSR122_1701(argE)
HRRHZS55_04395
HPELHZS54_04345
HLTI7X12_08385
HARCHARCEL1_01505
HDOMUK72_02345
HWAHQ_3718A(argE2)
HWCHqrw_4133(argE2)
HVOHVO_0042(argE)
HMEHFX_0042(argE)
HGIABY42_00200
HALEG3A49_00590
HBOHbor_01770
HAQDU484_03065
HAJDU500_03505
HAERDU502_01250
HRAEI982_12705
HLMDV707_00760
HALMFCF25_06945
HLAHlac_2612
HALPDOS48_13115
HALBEKH57_10835
HEZZEO776_15115
HALQHrr1229_007355
HSSJ7656_01805
HSAIHPS36_07340
HAZZKI388_13100
SRUBC2R22_20800
HAEhalTADL_1877
HALNB4589_001595
HALGHUG10_12775
HALUHUG12_02020
HMPK6T50_10095
HREK6T36_09860
HRMK6T25_06280
HACBHbl1158_01745
HDFAArcSl_0039(argE)
HAHHalar_1206
HTUHtur_0324
HDABB347_12530
HJTDVR14_08490
HALYHYG82_14955
HSALJMJ58_07555
HLOJ0X27_11110
HAKZJ0X25_08115
NMGNmag_1757(argE)
HXAHalxa_1382
NATNJ7G_0259
NPENatpe_3682
NVRFEJ81_17585
NPLFGF80_16410
NAYHYG81_11440
NGENatgr_1616
HRUHalru_0403
NOUNatoc_0152
SALIL593_07905
SAIMK0C01_05775
HLRHALLA_05510
HLCCHINAEXTREME04195
NAJB1756_08230
NAGAArcMg_3558
NANAArc1_3502
NBGDV706_07710
NASGCU68_04985
PTOPTO1468
FACFACI_IFERC01G1528
FAIFAD_0509(lysK)
CDIVCPM_0544
APEAPE_1467.1(lysK)
ACJACAM_0925(lysK)
IHOIgni_0664
IISEYM_06525
IAGIgag_1750
PFMPyrfu_1737
PDLPyrde_1839
STOSTK_01900(lysK)
SOHD1869_00420
SSOSSO0162
SOLSsol_1139
SSOASULA_1175
SSOLSULB_1176
SSOFSULC_1174
SSHIJ5U23_00103
SCASSACC_00740
SAISaci_0756
SACNSacN8_03675
SACRSacRon12I_03660
SACSSUSAZ_03390
SISLS215_2143
SIAM1425_1978
SIMM1627_2056
SIDM164_1984
SIYYG5714_2101
SINYN1551_0817
SIILD85_2239
SIHSiH_1922
SIRSiRe_1849
SICSiL_1831
SULABFU36_05130
SULEGFS03_10835
SULOGFS33_02650
SULLEWF20_01860
MSEMsed_0170
MCNMcup_1903
MHKDFR87_05960
MPRUDFR88_05790
MTENGWK48_06240
MJNMjAS7_0753
AHOAhos_0889
AMANB6F84_08295
ABRIDFR85_06550
ASULDFR86_07310
AAMBD1866_12340
ACIHHS5_22640
SACDHS1genome_0850
SAZOD1868_01565
CSTYKN1_18110
STEPIC006_1908
PAIPAE2798
PISPisl_1394
PCLPcal_1259
PASPars_0867
PYRP186_1739
POGPogu_1471
TNETneu_1861
PYWPYWP30_02010
CMACmaq_1676
TTNTTX_0118(lysK_argE)
TUZTUZN_1280
VDIVdis_0199
VMOVMUT_1537
NMRNmar_1296
NIRNSED_07190
NKRNKOR_07315
NIDNPIRD3C_0828
NINNADRNF5_0660
NIWNisw_07250
NCLC5F47_06980
NOXC5F49_06990
NUEC5F50_09745
NIPNsoK4_01560
NCTNMSP_0392
NICDSQ20_07945
CSYCENSYa_0125
NGANgar_c14550(lysK)
NVNNVIE_002650(lysK)
NEVNTE_01581
TAANMY3_02229(dapE_2)
NFNNFRAN_2991(dapE)
NCVNCAV_1408
CSUCSUB_C1309
NBVT478_1051
TAHSU86_009040
NIUDSQ19_03185
NDVNDEV_1631
CCAINAS2_0273
KCRKcr_0814
BARBAOA66_0023
 » show all
Reference
1  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_0756]
Reference
2  [PMID:27566549]
  Authors
Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M
  Title
Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.
  Journal
J Biol Chem 291:21630-21643 (2016)
DOI:10.1074/jbc.M116.743021
  Sequence
[tko:TK0274]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.132
IUBMB Enzyme Nomenclature: 3.5.1.132
ExPASy - ENZYME nomenclature database: 3.5.1.132
BRENDA, the Enzyme Database: 3.5.1.132
LinkDB

KEGG   REACTION: R10933
Entry
R10933                      Reaction                               
Name
LysW-L-ornithine amidohydrolase
Definition
LysW-L-ornithine + H2O <=> L-Ornithine + alpha-Aminoadipate carrier protein LysW
Equation
Reaction class
RC00064  C00077_C20951
RC00090  C19885_C20951
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn01100  Metabolic pathways
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00763  Ornithine biosynthesis, mediated by LysW, glutamate => ornithine
Orthology
K05831  [amino group carrier protein]-lysine/ornithine hydrolase [EC:3.5.1.130 3.5.1.132]
Other DBs
RHEA: 52679
LinkDB

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