KEGG   ORTHOLOGY: K05907
Entry
K05907                      KO                                     
Symbol
APR
Name
adenylyl-sulfate reductase (glutathione) [EC:1.8.4.9]
Pathway
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K05907  APR; adenylyl-sulfate reductase (glutathione)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.4  With a disulfide as acceptor
    1.8.4.9  adenylyl-sulfate reductase (glutathione)
     K05907  APR; adenylyl-sulfate reductase (glutathione)
Other DBs
RN: R05717
GO: 0033741
Genes
AJM: 119057277
ATH: AT1G62180(APR2) AT4G04610(APR1) AT4G21990(APR3)
ALY: 9303872 9310871 9322553
CRB: 17880982 17883322 17896630
CSAT: 104703816 104707608 104714551 104716805 104718119 104722840 104731320 104737308 104752870
EUS: EUTSA_v10023459mg EUTSA_v10025134mg EUTSA_v10028642mg
BRP: 103839826 103848153 103859677 103861274
BNA: 106346634 106347879 106366895 106396567 106418321 106418329 106420885 106435512 106440433 106442702 111212167
BOE: 106306507 106310441 106319498 106342464
RSZ: 108824435 108828637 108829478 108829485 108842087 108842851 108848746 108851680
TCC: 18597168
EGR: 104441413
CAM: 101505158
LJA: Lj4g3v0149340.1(Lj4g3v0149340.1) Lj6g3v1872560.1(Lj6g3v1872560.1)
FVE: 101296464
RCN: 112165291
RCU: 8284186
BVG: 104900978
SOE: 110792539
NCOL: 116246043
OSA: 4343348
DOSA: Os07t0509800-01(Os07g0509800)
OBR: 102709478
BDI: 100828269
ATS: 109738044
SBI: 8080734
SITA: 101776145
SVS: 117843700
PHAI: 112881988
MUS: 103975596
DCT: 110111790
PEQ: 110030804
ATR: 18445736
PPP: 112281535
APRO: F751_6755
OLU: OSTLU_13445(APR1)
EHX: EMIHUDRAFT_455311(PAPR)
 » show all
Reference
PMID:8917599
  Authors
Gutierrez-Marcos JF, Roberts MA, Campbell EI, Wray JL
  Title
Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and "APS reductase" activity.
  Journal
Proc Natl Acad Sci U S A 93:13377-82 (1996)
DOI:10.1073/pnas.93.23.13377
  Sequence
Reference
PMID:8917600
  Authors
Setya A, Murillo M, Leustek T
  Title
Sulfate reduction in higher plants: molecular evidence for a novel 5'-adenylylsulfate reductase.
  Journal
Proc Natl Acad Sci U S A 93:13383-8 (1996)
DOI:10.1073/pnas.93.23.13383
LinkDB

KEGG   ENZYME: 1.8.4.9
Entry
EC 1.8.4.9                  Enzyme                                 
Name
adenylyl-sulfate reductase (glutathione);
5'-adenylylsulfate reductase (also used for EC 1.8.99.2);
AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming);
plant-type 5'-adenylylsulfate reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)
Reaction(IUBMB)
AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione [RN:R05717]
Reaction(KEGG)
R05717
Substrate
AMP [CPD:C00020];
sulfite [CPD:C00094];
glutathione disulfide [CPD:C00127]
Product
adenylyl sulfate [CPD:C00224];
glutathione [CPD:C00051]
Comment
This enzyme differs from EC 1.8.99.2, adenylyl-sulfate reductase, in using glutathione as the reductant. Glutathione can be replaced by gamma-glutamylcysteine or dithiothreitol, but not by thioredoxin, glutaredoxin or 2-sulfanylethan-1-ol (2-mercaptoethanol). The enzyme from the mouseear cress, Arabidopsis thaliana, contains a glutaredoxin-like domain. The enzyme is also found in other photosynthetic eukaryotes, e.g., the Madagascar periwinkle, Catharanthus roseus and the hollow green seaweed, Ulva intestinalis.
History
EC 1.8.4.9 created 2000, modified 2002
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05907  adenylyl-sulfate reductase (glutathione)
Genes
AJM119057277
ATHAT1G62180(APR2) AT4G04610(APR1) AT4G21990(APR3)
ALY9303872 9310871 9322553
CRB17880982 17883322 17896630
CSAT104703816 104707608 104714551 104716805 104718119 104722840 104731320 104737308 104752870
EUSEUTSA_v10023459mg EUTSA_v10025134mg EUTSA_v10028642mg
BRP103839826 103848153 103859677 103861274
BNA106346634 106347879 106366895 106396567 106418321 106418329 106420885 106435512 106440433 106442702 111212167
BOE106306507 106310441 106319498 106342464
RSZ108824435 108828637 108829478 108829485 108842087 108842851 108848746 108851680
THJ104806307 104809496 104818752
CPAP110808072 110820839 110820876
CIT102626298 102626350
CICCICLE_v10010222mg CICLE_v10015162mg
PVY116137243 116142891 116142895
MINC123192770 123219166
TCC18597168
GRA105769511 105773448
GHI107900590 107905918 107958280 107961997
GAB108452964 108486674
DZI111275205 111278275
EGR104441413
GMX100799978 100819536 547630
GSJ114367269 114387349 114420178
PVUPHAVU_003G079800g PHAVU_006G149200g
VRA106766568 106775990
VAR108336023 108343304
VUN114174957 114187852
CCAJ109803660 109809738
APRC113846354 113847166
MTRMTR_2g023540
CAM101505158
LJALj4g3v0149340.1(Lj4g3v0149340.1) Lj6g3v1872560.1(Lj6g3v1872560.1)
ADU107466613 107479096 107482990
AIP107636252 107638633
AHF112705822 112722891 112741226 112795922
LANG109329867 109333726 109342504 109345338
FVE101296464
RCN112165291
PPER18778340 18779258
PMUM103324412 103324413 103326433
PAVI110748229 110762244 110763068
PDUL117624010 117624459
MDM103408766 103409471
PXB103948191 103949894 103951376
ZJU107407239 107420715
MNT112095244 21391473 21401025 21401026
CSV101211864 101220567
CMO103484617 103485224
BHJ120072791 120083844
MCHA111010712 111012338
CMAX111477996 111490004 111495445
CMOS111431516 111453522 111456956
CPEP111783406 111802499 111803510
RCU8284186
HBR110639463 110670643
MESC110602822 110605077
POP18097381 18097384 7462058
PEU105134776 105141663
PALZ118040296 118058881
JRE108985688 109006940 109020834
QSU112014192 112030971
QLO115957421 115989634
TWL119989640 119990033
VVI100233045 100853787 100854884
VRI117923987 117926670
SLY101252466 101257319 544267
SPEN107011261 107011717 107012556
SOT102579112 102587128 102600029(apsr1)
CANN107858434 107859594
NTA107768720 107789753 107799658 107801230 107811452 107829885
NSY104218889 104248308 104249938
NTO104098181 104106256 104111505
NAU109212240 109222466 109238139 109245027
INI109164888 109165701 109167270
ITR116027425 116029479 116032225
SIND105167991 105175419
OEU111395949 111395977 111402425
EGT105962230 105968964
SSPL121745534 121775254 121783581 121787533 121808601
HAN110910798 110918325 110939621
ECAD122590947 122595134
LSV111891058 111907858
CCAV112522741 112525036
DCR108204316 108210263
CSIN114259072 114263981 114276131
BVG104900978
SOE110792539
CQI110687384 110703043 110720709 110731321
NNU104588316 104612772
MING122059929 122092831
TSS122639623 122643127
PSOM113287967 113305261 113315016 113348553
NCOL116246043
OSA4343348
DOSAOs07t0509800-01(Os07g0509800)
OBR102709478
BDI100828269
ATS109738044
TDC119354341 119363511
TAES123044707 123052570 123188457
SBI8080734
ZMA103647705 606419
SITA101776145
SVS117843700
PVIR120661463 120689191
PHAI112881988
PDA103707194 103719146
EGU105036141 105050935
MUS103975596
DCT110111790
PEQ110030804
AOF109833481 109849392
ATR18445736
SMOSELMODRAFT_167572 SELMODRAFT_187782
PPP112281535
CRECHLRE_12g517150v5
VCNVOLCADRAFT_103701
CSLCOCSUDRAFT_22587
CVRCHLNCDRAFT_33215
APROF751_6755
OLUOSTLU_13445(APR1)
OTAOT_ostta14g00360
BPGBathy04g04910
MISMICPUN_87762
MPPMICPUCDRAFT_53472
CMECYME_CMT162C
GSLGasu_09200
CCPCHC_T00009224001
EHXEMIHUDRAFT_455311(PAPR)
 » show all
Reference
1  [PMID:8917599]
  Authors
Gutierrez-Marcos JF, Roberts MA, Campbell EI, Wray JL
  Title
Three members of a novel small gene-family from Arabidopsis thaliana able to complement functionally an Escherichia coli mutant defective in PAPS reductase activity encode proteins with a thioredoxin-like domain and "APS reductase" activity.
  Journal
Proc Natl Acad Sci U S A 93:13377-82 (1996)
DOI:10.1073/pnas.93.23.13377
  Sequence
Reference
2  [PMID:8917600]
  Authors
Setya A, Murillo M, Leustek T
  Title
Sulfate reduction in higher plants: molecular evidence for a novel 5'-adenylylsulfate reductase.
  Journal
Proc Natl Acad Sci U S A 93:13383-8 (1996)
DOI:10.1073/pnas.93.23.13383
  Sequence
[ath:AT4G04610]
Reference
3  [PMID:9653199]
  Authors
Bick JA, Aslund F, Chen Y, Leustek T.
  Title
Glutaredoxin function for the carboxyl-terminal domain of the plant-type 5'-adenylylsulfate reductase.
  Journal
Proc Natl Acad Sci U S A 95:8404-9 (1998)
DOI:10.1073/pnas.95.14.8404
  Sequence
[ath:AT4G04610]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.9
IUBMB Enzyme Nomenclature: 1.8.4.9
ExPASy - ENZYME nomenclature database: 1.8.4.9
BRENDA, the Enzyme Database: 1.8.4.9
CAS: 355840-27-6
LinkDB

KEGG   REACTION: R05717
Entry
R05717                      Reaction                               
Name
AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)
Definition
AMP + Sulfite + Glutathione disulfide <=> Adenylyl sulfate + 2 Glutathione
Equation
Reaction class
RC00007  C00020_C00224
RC00011  C00051_C00127
RC02862  C00094_C00224
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K05907  adenylyl-sulfate reductase (glutathione) [EC:1.8.4.9]
Other DBs
RHEA: 14144
LinkDB

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