KEGG   ORTHOLOGY: K05915
Entry
K05915            Tight     KO                                     
Symbol
phnZ1
Name
(hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase [EC:1.13.11.89 1.13.11.78]
Pathway
map00440  Phosphonate and phosphinate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.78  2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
     K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
    1.13.11.89  (hydroxymethyl)phosphonate dioxygenase
     K05915  phnZ1; (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Other DBs
RN: R10722 R12451
COG: COG4341
Genes
GMR: GmarT_03180
Reference
PMID:30810303
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
[gmr:GmarT_03180]
LinkDB

KEGG   ENZYME: 1.13.11.89
Entry
EC 1.13.11.89               Enzyme                                 
Name
(hydroxymethyl)phosphonate dioxygenase;
phnZ1 (gene name)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
(hydroxymethyl)phosphonate:oxygen 1-oxidoreductase (formate-forming)
Reaction(IUBMB)
(hydroxymethyl)phosphonate + O2 = formate + phosphate [RN:R12451]
Reaction(KEGG)
R12451
Substrate
hydroxymethylphosphonate [CPD:C06455];
O2 [CPD:C00007]
Product
formate [CPD:C00058];
phosphate [CPD:C00009]
Comment
Requires iron(II). The enzyme, characterized from the marine bacterium Gimesia maris, participates in a methylphosphonate degradation pathway. It also has the activity of EC 1.13.11.78, (2-amino-1-hydroxyethyl)phosphonate dioxygenase (glycine-forming).
History
EC 1.13.11.89 created 2019
Pathway
ec00440  Phosphonate and phosphinate metabolism
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase
Genes
GMR: GmarT_03180
Reference
1  [PMID:30810303]
  Authors
Gama SR, Vogt M, Kalina T, Hupp K, Hammerschmidt F, Pallitsch K, Zechel DL
  Title
An Oxidative Pathway for Microbial Utilization of Methylphosphonic Acid as a Phosphate Source.
  Journal
ACS Chem Biol 14:735-741 (2019)
DOI:10.1021/acschembio.9b00024
  Sequence
[gmr:GmarT_03180]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.89
IUBMB Enzyme Nomenclature: 1.13.11.89
ExPASy - ENZYME nomenclature database: 1.13.11.89
BRENDA, the Enzyme Database: 1.13.11.89
LinkDB

KEGG   REACTION: R12451
Entry
R12451                      Reaction                               
Name
(hydroxymethyl)phosphonate:oxygen 1-oxidoreductase (formate-forming)
Definition
Hydroxymethylphosphonate + Oxygen <=> Formate + Orthophosphate
Equation
C06455 + C00007 <=> C00058 + C00009
Reaction class
RC03544  C00058_C06455
Enzyme
1.13.11.89
Pathway
rn00440  Phosphonate and phosphinate metabolism
Orthology
K05915  (hydroxymethyl)phosphonate/2-amino-1-hydroxyethylphosphonate dioxygenase [EC:1.13.11.89 1.13.11.78]
Other DBs
RHEA: 60003
LinkDB

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