Entry
Name
precorrin-3B C17-methyltransferase;
precorrin-3 methyltransferase;
CobJ
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 [RN:
R05180 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
precorrin 3B [CPD:
C06406 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
precorrin 4 [CPD:
C06407 ]
Comment
The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. See EC
2.1.1.272 , cobalt-factor III methyltransferase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.131 created 1999
Pathway
Orthology
K05934 precorrin-3B C17-methyltransferase / cobalt-factor III methyltransferase
K13540 precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase
K13541 cobalt-precorrin 5A hydrolase / cobalt-factor III methyltransferase / precorrin-3B C17-methyltransferase
Genes
SETC : CFSAN001921_06650(cbiH)
SEEN : SE451236_16345(cbiH)
SENH : CFSAN002069_21685(cbiH)
SEEH : SEEH1578_19415(cbiH)
SENJ : CFSAN001992_01300(cbiH)
SEEC : CFSAN002050_17095(cbiH)
SEEB : SEEB0189_009330(cbiH)
SENC : SEET0819_17280(cbiH)
KIE : NCTC12125_04868(cbiH)
BUF : D8682_20860 D8682_24240
METY : MRY16398_18710(cbiH)
PAEB : NCGM1900_3408(cobJ)
PAEU : BN889_03244(cobJ_2)
PPRC : PFLCHA0_c06670(cobJ)
PFW : PF1751_v1c05690(cobJ)
PPUU : PputUW4_00541(cobJ)
PTRT : HU722_0003940(cobJ)
PTW : TUM18999_08410(cobJ)
PTAE : NCTC10697_03992(cobJ)
GAI : IMCC3135_08945(cobJ)
BMV : BMASAVP1_A1605(cbiG_cobJ)
BML : BMA10229_A0267(cbiG_cobJ)
BMN : BMA10247_0893(cbiG_cobJ)
BPM : BURPS1710b_2110(cobJ)
BPL : BURPS1106A_1964(cbiG_cobJ)
PLG : NCTC10937_00833(cobJ)
LMIR : NCTC12852_01764(cbiH)
MPT : Mpe_B0447(cobJ) Mpe_B0482(cobJ)
AZA : AZKH_4165(cbiH_cobJ)
DMM : dnm_047320(cobJ) dnm_086630
SMEL : SM2011_c03190(cobJ)
SFD : USDA257_c53940(cobJ)
SAME : SAMCFNEI73_Ch3350(cobJ)
AGR : AGROH133_09252(cobJ)
RET : RHE_CH02486(cobE) RHE_PE00452(cobJ)
REC : RHECIAT_PA0000375(cobJ)
REL : REMIM1_PD00475(cobJ)
REP : IE4803_PA00411(cobJ)
REI : IE4771_PC00424(cobJ)
RLE : RL2826(cobE) pRL110628(cobJ)
RTR : RTCIAT899_PC07005(cobJ)
RHL : LPU83_pLPU83d0184(cobJ)
RGA : RGR602_PC01213(cobJ)
RPHA : AMC79_PB00384(cobJ)
NEN : NCHU2750_36480(cobJ)
SZO : K8M09_09605 K8M09_16555
BMEL : DK63_715(cobJ) DK63_728
BMI : BMEA_A1336(cobJ) BMEA_A1348
BMZ : BM28_A1300(cbiG) BM28_A1314
BMG : BM590_A1291 BM590_A1305
BMW : BMNI_I1250 BMNI_I1264
BMEE : DK62_126 DK62_139(cobJ)
BMB : BruAb1_1290 BruAb1_1302
BMC : BAbS19_I12200 BAbS19_I12340
BAA : BAA13334_I01900 BAA13334_I01925
BABO : DK55_1284(cobJ) DK55_1297
BABR : DO74_594 DO74_606(cobJ)
BABT : DK49_1041(cobJ) DK49_1053
BABB : DK48_823 DK48_836(cobJ)
BABU : DK53_1268(cobJ) DK53_1280
BABS : DK51_180 DK51_192(cobJ)
BABC : DO78_1189(cobJ) DO78_1201
BSI : BS1330_I1285 BS1330_I1297
BSF : BSS2_I1256 BSS2_I1268
BSUI : BSSP1_I0392(cobE) BSSP1_I0404(cobJ)
BSUP : BSPT1_I0399(cobE) BSPT1_I0411(cobJ)
BSUV : BSPT2_I0394(cobE) BSPT2_I0406(cobJ)
BSUC : BSSP2_I1315(cobJ) BSSP2_I1327(cobE)
BMT : BSUIS_A1339(cobJ) BSUIS_A1351(cobE)
BSZ : DK67_1009(cobJ) DK67_997
BSV : BSVBI22_A1285 BSVBI22_A1297
BSW : IY71_06380 IY71_06440
BSG : IY72_06120 IY72_06180
BCS : BCAN_A1312(cobJ) BCAN_A1324(cobE)
BSK : BCA52141_I3106 BCA52141_I3126
BOL : BCOUA_I1289 BCOUA_I1301
BCAR : DK60_1328(cobJ) DK60_1340
BCAS : DA85_06185 DA85_06245
BMR : BMI_I1302(cobJ) BMI_I1314
BPP : BPI_I1341(cobJ) BPI_I1353
BPV : DK65_79 DK65_91(cobJ)
BVL : BF3285c1_2100(cobJ) BF3285c1_2114
BRU : BFS01_06230 BFS01_06300
BRJ : BKD03_15630 BKD03_15690
BIO : BR141012304_11396 BR141012304_11408(cobJ)
BSEP : HAP48_0032375(cobJ)
MAQU : Maq22A_c09445(cobJ)
MMES : MMSR116_15290(cobJ)
MTUN : MTUNDRAET4_2077(cobJ)
FIL : BN1229_v1_3172(cobJ)
FIY : BN1229_v1_2750(cobJ)
DEA : FPZ08_00575 FPZ08_01585
RLI : RLO149_c006210(cobJ)
PHP : PhaeoP97_00780(cobJ)
PPIC : PhaeoP14_00735(cobJ)
SINL : DSM14862_03169(cobJ)
SPSE : SULPSESMR1_02792(cobJ)
RMM : ROSMUCSMR3_03055(cobJ)
AHT : ANTHELSMS3_02549(cobJ)
LVS : LOKVESSMR4R_00337(cobJ)
GEH : HYN69_05165(cobJ) HYN69_19255(cobJ) HYN69_20065(cobJ)
BON : A361_03605 A361_27950
LFU : HR49_01340 HR49_12990
LMOC : LMOSLCC5850_1188(cbiH)
LMW : LMOSLCC2755_1191(cbiH)
LMX : LMOSLCC2372_1195(cbiH)
LMZ : LMOSLCC2482_1239(cbiH)
LMON : LMOSLCC2376_1150(cbiH)
LMOS : LMOSLCC7179_1166(cbiH)
LMOO : LMOSLCC2378_1204(cbiH)
LMOY : LMOSLCC2479_1196(cbiH)
LMOT : LMOSLCC2540_1178(cbiH)
LMOA : LMOATCC19117_1198(cbiH)
SOB : CSE16_00840 CSE16_07470
SMEN : SAMEA4412692_0361(cbiH)
LRU : HMPREF0538_20901(cobJ)
AUR : HMPREF9243_1734(cobJ)
CTYK : CTK_C09500(cbiH_cobJ)
CCOH : SAMEA4530647_0622(cbiH)
BPRO : PMF13cell1_04264(cbiH)
CSCI : HDCHBGLK_00120(cbiH)
ACEL : acsn021_39670(cbiH)
ACHT : bsdcttw_22320(cbiH)
PDF : CD630DERM_34240(cbiH)
EAC : EAL2_808p01060(cbiH)
PHX : KGNDJEFE_00486(cbiH)
CBAR : PATL70BA_0224(cbiH)
AMIC : Ami3637_15820(cobJ)
ABUT : Ami103574_09195(cobJ)
ETM : CE91St48_21110(cbiH)
PIV : NCTC13079_00693(cbiH)
SPOA : EQM13_01820(cobJ) EQM13_15080
VRM : 44547418_01211(cbiH)
VDN : NCTC11831_00752(cbiH)
MANA : MAMMFC1_04002(cbiH)
PFAC : PFJ30894_01757(cbiH)
MMAE : MMARE11_29690(cobI)
MGO : AFA91_20120 AFA91_20695
MBAI : MB901379_02825(cobI)
MHEK : JMUB5695_02275(cobIJ)
MPHL : MPHLCCUG_02699(cobI)
MTHN : 4412656_01957(cobI_1)
MAUU : NCTC10437_03306(cobI)
MFLV : NCTC10271_02122(cobI)
MSAL : DSM43276_01911(cobI)
MTER : 4434518_03150(cobI)
CDD : CDCE8392_1134(cobIJ)
CDIP : ERS451417_01233(cobIJ)
COI : CPCIP5297_05330(cobJ)
CUN : Cul210932_1135(cobJ)
CUQ : Cul210931_1087(cobJ)
CUJ : CUL131002_1119(cobJ)
NFR : ERS450000_00921(cobI)
NAD : NCTC11293_04432(cobI)
NHU : H0264_20975 H0264_30005
REQ : REQ_23560(cobI_cobJ)
RPY : Y013_10505 Y013_14625
RCR : NCTC10994_03357(cobI)
SCT : SCAT_1054 SCAT_p1405(cobIJ)
SCY : SCATT_10480 SCATT_p03210
STRF : ASR50_09010 ASR50_31635
SLE : sle_52760(sle_52760)
SALF : SMD44_02005(cbiGH-cobJ)
SVR : CP971_05295 CP971_09060
SCOE : CP976_10545(cobJ) CP976_34775
KAU : B6264_00700 B6264_04120
KIT : CFP65_4032 CFP65_6482
DCO : SAMEA4475696_1935(cobI)
PAK : HMPREF0675_3455(cobJ)
CGRN : 4412665_00756(cbiH)
PAUS : NCTC13651_00950(cbiH)
PPC : HMPREF9154_0396(cobJ)
TEZ : BKM78_01675 BKM78_05765
TLA : TLA_TLA_00341(cobIJ) TLA_TLA_01166(cbiH)
RAIN : Rai3103_03660(cobJ) Rai3103_07660(cobJ)
NAQU : ENKNEFLB_00279(cobIJ_1) ENKNEFLB_01626(cobIJ_2)
APRE : CNX65_08880 CNX65_28735
SESP : BN6_25810(cobIJ) BN6_70160(cbiG)
SSYI : EKG83_11645 EKG83_39325
KPHY : AOZ06_33205 AOZ06_33705
SACE : GIY23_16875 GIY23_16910
MSAG : GCM10017556_51990(cobI)
SYG : sync_0391(cbiG_cobJ)
SYR : SynRCC307_2160(cbiG)
SYX : SynWH7803_0388(cbiG)
CYA : CYA_1591(cbiG_cobJ-1) CYA_1847(cbiG_cobJ-2)
SYH : Syncc8109_0335(cobJ)
SYNW : SynWH8103_02442(cobJ)
PMM : PMM1525(cbiG_cobJ_fusion)
TVN : NIES2134_112480(cobJ)
LET : O77CONTIG1_00345(cbiH)
MVZ : myaer102_16530(cobJ_2)
PAGH : NIES204_04470(cobJ)
DOU : BMF77_04143(cobIJ_1)
DFO : Dform_01778(cbiGH-cobJ)
MRU : mru_0890(cbiH1) mru_2210(cbiH)
MCHK : MchiMG62_06360(cobJ)