KEGG   ORTHOLOGY: K05953
Entry
K05953                      KO                                     
Symbol
NAS
Name
nicotianamine synthase [EC:2.5.1.43]
Pathway
map00270  Cysteine and methionine metabolism
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K05953  NAS; nicotianamine synthase
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various plant secondary metabolites
    K05953  NAS; nicotianamine synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.43  nicotianamine synthase
     K05953  NAS; nicotianamine synthase
Other DBs
RN: R00075
GO: 0030410
Genes
BTAB: 109044732
ATH: AT1G09240(NAS3) AT1G56430(NAS4) AT5G04950(NAS1) AT5G56080(NAS2)
ALY: 9300505 9309245 9328021 9328557
CRB: 17877070 17880913 17881818 17896008 17898438
CSAT: 104701054 104708618 104717596 104730756 104732729 104734502 104739516 104754956 104755112 104758977 104761659 104766177 104767547 104768692 104787782 104789480
EUS: EUTSA_v10008206mg EUTSA_v10013812mg EUTSA_v10014123mg EUTSA_v10024166mg EUTSA_v10026750mg
BRP: 103845041 103847238 103847645 103851850 103855599 103866247 103867728 103871652
BNA: 106346288 106370283 106379260 106379334 106385040 106412811 106415799 106416128 106418370 106419284 106428166 106428315 106444095 106445243 106449316 106453283 111213986
BOE: 106294597 106310962 106315343 106316021 106325609 106327744 106329314
RSZ: 108816722 108840442 108841297 108843450 108844640 108845407 108850421 108860857
LJA: Lj1g3v4790630.1(Lj1g3v4790630.1) Lj3g3v1048990.1(Lj3g3v1048990.1) Lj6g3v1914550.1(Lj6g3v1914550.1)
SLY: 101248619(CHLN)
SPEN: 107011178
SOT: 102578513
CANN: 107839697
NTA: 107762888 107808712(NtNAS1) 107814310 107817799(NtNAS2)
BVG: 104890766
SOE: 110796718
DOSA: Os03t0307200-01(Os03g0307200) Os03t0307300-01(Os03g0307300) Os07t0689600-01(Os07g0689600)
DCT: 110105313
PEQ: 110032766
 » show all
Reference
  Authors
Ling HQ, Koch G, Baumlein H, Ganal MW
  Title
Map-based cloning of chloronerva, a gene involved in iron uptake of higher plants encoding nicotianamine synthase.
  Journal
Proc Natl Acad Sci U S A 96:7098-103 (1999)
DOI:10.1073/pnas.96.12.7098
  Sequence
[sly:101248619]
Reference
  Authors
Inoue H, Higuchi K, Takahashi M, Nakanishi H, Mori S, Nishizawa NK
  Title
Three rice nicotianamine synthase genes, OsNAS1, OsNAS2, and OsNAS3 are expressed in cells involved in long-distance transport of iron and differentially regulated by iron.
  Journal
Plant J 36:366-81 (2003)
DOI:10.1046/j.1365-313x.2003.01878.x
LinkDB

KEGG   ENZYME: 2.5.1.43
Entry
EC 2.5.1.43                 Enzyme                                 
Name
nicotianamine synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine [RN:R00075]
Reaction(KEGG)
R00075
Substrate
S-adenosyl-L-methionine [CPD:C00019]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
nicotianamine [CPD:C05324]
History
EC 2.5.1.43 created 1999
Pathway
ec00270  Cysteine and methionine metabolism
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05953  nicotianamine synthase
Genes
BTAB109044732
ATHAT1G09240(NAS3) AT1G56430(NAS4) AT5G04950(NAS1) AT5G56080(NAS2)
ALY9300505 9309245 9328021 9328557
CRB17877070 17880913 17881818 17896008 17898438
CSAT104701054 104708618 104717596 104730756 104732729 104734502 104739516 104754956 104755112 104758977 104761659 104766177 104767547 104768692 104787782 104789480
EUSEUTSA_v10008206mg EUTSA_v10013812mg EUTSA_v10014123mg EUTSA_v10024166mg EUTSA_v10026750mg
BRP103845041 103847238 103847645 103851850 103855599 103866247 103867728 103871652
BNA106346288 106370283 106379260 106379334 106385040 106412811 106415799 106416128 106418370 106419284 106428166 106428315 106444095 106445243 106449316 106453283 111213986
BOE106294597 106310962 106315343 106316021 106325609 106327744 106329314
RSZ108816722 108840442 108841297 108843450 108844640 108845407 108850421 108860857
THJ104811690 104816890 104820632
CPAP110815380 110821244 110826411
CIT102608515 102609096 102609384 102609958 102621359
CICCICLE_v10001872mg CICLE_v10010328mg CICLE_v10010369mg CICLE_v10010452mg CICLE_v10010757mg
PVY116106954 116108649 116108744 116108807 116108817 116115971 116115972 116117803
MINC123193914 123206447 123221634
TCC18589241 18600574 18603633
GRA105761119 105767526 105781107 105792468 105793510
GHI107888338 107893879 107894796 107919611 107926213 107927171 107933758 121209352 121217412 121229198
GAB108463453 108468137 108469508 108472923 108485933
DZI111277381 111296000 111301967 111307514
EGR104414670 104428248
GMX100775553 100794250 100803630 100814069 100819726
GSJ114367111 114387347 114399003 114407543 114424311
PVUPHAVU_001G225000g PHAVU_005G052500g PHAVU_006G117300g
VRA106754071 106756794 106761843
VAR108328177 108333725 108342357
VUN114186325 114187489 114194913
CCAJ109790589 109797885 109806164
APRC113853087 113856646 113861932
MTRMTR_1g084050 MTR_2g034240 MTR_2g070310 MTR_7g112130
CAM101509924 101510352 101513314 101514194
LJALj1g3v4790630.1(Lj1g3v4790630.1) Lj3g3v1048990.1(Lj3g3v1048990.1) Lj6g3v1914550.1(Lj6g3v1914550.1)
ADU107459596 107465178 107492163
AIP107612042 107619807 107645954
AHF112695583 112703449 112710725 112758211 112768963 112779605
LANG109332192 109345844 109353668 109353704 109353753 109354068 109354808
FVE101313617 101314050
RCN112180476 112193312
PPER18772486 18790379
PMUM103323493 103344131
PAVI110747490 110762851
PDUL117622689 117631595
MDM103433868 103450853
PXB103930560 103962314
ZJU107411605 107418990
MNT21385396 21405701
CSV101203651 101209464 101218907 101219339
CMO103492113 103494174 103494189 103494275
BHJ120070769 120071986 120080081 120080591
MCHA111023309 111025239
CMAX111465632 111485338 111486493 111493502
CMOS111430119 111437742 111444226 111450477
CPEP111780548 111785688 111792563 111799305 111804749
RCU8258799 8261713 8261714 8269821 8279286
JCU105635605 105635610 105643528 105647424
HBR110645864 110651885
MESC110600540 110620263 110621562 110623696 110630864 110630877
POP112327503 112327508 18098035
PEU105112194 105115144 105135643
PALZ118038804 118046328 118047659 118051673
JRE108981230 108987758 108998835
QSU111986344 112028738
QLO115980241 115981763 115981915 115994087
TWL119996994 120006679 120008560 120010986 120013803
VVI100244492 100254544
VRI117924928 117929515
SLY101248619(CHLN)
SPEN107011178
SOT102578513
CANN107839697
NTA107762888 107808712(NtNAS1) 107814310 107817799(NtNAS2)
NSY104237053 104249606
NTO104104973 104111414
NAU109223070 109233844
INI109174557 109180988 109182336
ITR116005496 116007614 116025017
SIND105168955 105172429
OEU111385856 111390250 111409892
EGT105954593 105958225
SSPL121754187 121758965 121807355
HAN110877899 110885610 110890233 110913169 110932790
ECAD122593477 122594208 122596364
LSV111878037 111878402 111878404 111878908
CCAV112503529 112505540
DCR108200806 108210142 108226336
CSIN114279165 114297104
BVG104890766
SOE110796718
CQI110701176 110736499
NNU104598782 104605079
MING122085701 122090294 122091275
TSS122646631 122660360 122669296
PSOM113286440 113286441 113291814 113301249 113306976 113326007 113332641 113333378 113334895 113348128 113348893 113352648 113352966 113352967 113352968 113353597 113353598 113353600 113353604 113354002 113354003 113358139 113359469 113361277
NCOL116250413 116254804 116262031
OSA4332607 4332608 4344361
DOSAOs03t0307200-01(Os03g0307200) Os03t0307300-01(Os03g0307300) Os07t0689600-01(Os07g0689600)
OBR102699669 102702270 102715132 121055712
BDI100822873 100826723 100829217 100832895 100845767
ATS109733201 109738215 109738921 109739435 109741827 109748004 109776735 109777780 109779038 109787587 109787589
TDC119285513 119296327 119304374 119314708 119314969 119316430 119316432 119316457 119318492 119323111 119323112 119325023 119326313 119326368 119352811 119352918 119353188 119361851 119361948 119362308
TAES123040191 123043227 123043598 123048357 123051093 123051465 123059244 123083766 123094885 123097678 123099214 123099216 123106176 123106177 123130292 123130501 123130503 123130517 123131325 123131371 123133989 123133995 123135012 123135099 123141357 123141358 123142182 123144159 123146117 123184397 123187039 123187403
SBI110435426 8057220 8077509
ZMA100191831 100284978 100285295 103634563 103639224 103643789 109942391 110386945 541637 542480
SITA101770261 101774809 101786975
SVS117840190 117843618
PVIR120652617 120662235 120690551 120694915
PHAI112873937 112876381 112880351
PDA103698830 103700975
EGU105045032 105057353
MUS103968353 103971978 103971979 103985619
DCT110105313
PEQ110032766
AOF109835915 109842924 109850903
ATR18430237 18434693
 » show all
Reference
1
  Authors
Higuchi, K., Kanazawa, K., Nishizawa, N.-K., Chino, M., Mori, S.
  Title
Purification and characterization of nicotianamine synthase from Fe-deficient barley root.
  Journal
Plant Soil 165:173-179 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.43
IUBMB Enzyme Nomenclature: 2.5.1.43
ExPASy - ENZYME nomenclature database: 2.5.1.43
BRENDA, the Enzyme Database: 2.5.1.43
CAS: 161515-44-2
LinkDB

KEGG   REACTION: R00075
Entry
R00075                      Reaction                               
Name
S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase
Definition
3 S-Adenosyl-L-methionine <=> 3 5'-Methylthioadenosine + Nicotianamine
Equation
3 C00019 <=> 3 C00170 + C05324
Comment
multi-step reaction
Reaction class
RC00021  C00019_C00170
Enzyme
Pathway
rn00270  Cysteine and methionine metabolism
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K05953  nicotianamine synthase [EC:2.5.1.43]
Other DBs
RHEA: 16484
LinkDB

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