KEGG   ORTHOLOGY: K05961
Entry
K05961                      KO                                     
Symbol
dnk
Name
deoxynucleoside kinase [EC:2.7.1.145]
Pathway
map00230  Purine metabolism
map00240  Pyrimidine metabolism
map01100  Metabolic pathways
map01232  Nucleotide metabolism
Reaction
R01567  ATP:thymidine 5'-phosphotransferase
R01666  ATP:deoxycitidine 5'-phosphotransferase
R01967  ATP:deoxyguanosine 5'-phosphotransferase
R02089  ATP:deoxyadenosine 5'-phosphotransferase
R02099  ATP:deoxyuridine 5'-phosphotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K05961  dnk; deoxynucleoside kinase
   00240 Pyrimidine metabolism
    K05961  dnk; deoxynucleoside kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.145  deoxynucleoside kinase
     K05961  dnk; deoxynucleoside kinase
Other DBs
GO: 0019136
Genes
AAMU: 139934361
DME: Dmel_CG5452(dnk)
DER: 6554072
DSE: 6620705
DSI: Dsimw501_GD19261(Dsim_GD19261)
DYA: Dyak_GE25572
DAN: 6505870
DSR: 110186665
DPO: 4801838
DPE: 6588091
DMN: 108156402
DWI: 6647251
DGR: 6568426
DMO: Dmoj_GI10047
DAZ: 108620993
DNV: 108658836
DHE: 111602690
DVI: 6631195(dnk)
CCAT: 101450470
BOD: 106617808
BDR: 105231069
RZE: 108355448
AOQ: 129236198
ALUD: 128855559
TDA: 119680404 119681378
MDE: 101896877
SCAC: 106090041
LCQ: 111680959
LSQ: 119613191
CVJ: 135956818(dnk)
GFS: 119639424
ECOE: 129942128
CLON: 129605891 129612847
HIS: 119650996
AGA: 1281587
ACOZ: 120953957
AARA: 120898076
AMER: 121590743
ASTE: 118505597 118516567
AMAP: 126558772
AFUN: 125774874
AMOU: 128297035
AMRS: 128719419
AALI: 118461083
ADAR: 125948202
ACOS: 131272495
AAG: 5579214
AALB: 109405935 109417111 115266522
ASUA: 134205313
CQU: CpipJ_CPIJ003276
CPII: 120424947
CBRI: 134834111
CNS: 116347604 116350021 116351806
BCOO: 119069920 119070619 119075577 119079253 119085227
LLL: 129787213
PPAP: 129798829
AME: 552840
ACER: 107998280
ALAB: 122714892
ADR: 102672898
AFLR: 100871899
BIM: 100744576
BBIF: 117205012
BVK: 117230963
BVAN: 117153269
BHUN: 126871547
BTER: 100648317
BAFF: 126921834
BPYO: 122567739
BPAS: 132912725
FVI: 122537787
CCAL: 108626754
OBB: 114878736
OLG: 117602966
MGEN: 117221411
NMEA: 116423874
CGIG: 122398991
SOC: 105196060 105207545
MPHA: 105836053 105837551 118648111
AEC: 105144858 105146649
ACEP: 105623946 105626028
ACOC: 108689658 108693899
MZT: 108727417 108729376(dnk)
CCOA: 108779345 108782953
TCZ: 108757663 108764917
TSEP: 108753333
PBAR: 105422323 105427465
VEM: 105564478 105567866
COBS: 139110032(Dnk) 139111355
TLN: 139821156 139821544(Dnk)
HST: 105187065 105188611
DQU: 106741152 106749991
CFO: 105248838 105257645
FEX: 115238243 115243702
PMEC: 138932778 138940873(Dnk)
LHU: 105672005 105672239
PGC: 109856640 109858340
OBO: 105275914 105281382
PCF: 106784413
PFUC: 122519186
VPS: 122630646
VCRB: 124424167
VVE: 124950789 124950790
LHT: 122513012
LBD: 127284996
FAS: 105270889
DAM: 107041802
AGIF: 122861087
VCAN: 122412197
CCIN: 107262785
DSM: 124410894 124416581
NPT: 124215415(dnk)
NFB: 124179224
NLO: 107219391
NVG: 124300585
AROA: 105684234
TCA: 659303 659935 660567
TMOL: 138134634 138137700 138139629
DPA: 109542197 109546462
ESIM: 136415311 136420060
EFOR: 136340337 136344705
SOY: 115876628 115880872 115880987 115883471
RFG: 143197084 143199011 143206918
AGRG: 126746792 126747076 126747310
ATD: 109602144
CSET: 123319946 123321861
HAXR: 123682104 123685761
AGB: 108907401 108911548 108915258
LDC: 111501828 111511326
DVV: 114326361 126881083
NVL: 108559729 108561321 108567605
APLN: 108736123 108740527
PPYR: 116171896 116172019 116178371 116181669 116182896
OTU: 111416219 111424509 111429051
BMOR: 101741300 692569
BMAN: 114244024 114245792
MSEX: 115448679 115450116
DPL: KGM_201543 KGM_210835
BANY: 112044401 112051943
MJU: 123871697 123871853
NIQ: 126769380 126770645
VCD: 124529800 124532529
MCIX: 123655306 123657209
PMAC: 106707992 106716895
PPOT: 106109692 106111772
PXU: 106121104 106124000
BPHI: 137926499(dnk) 137932423
PRAP: 111000809 111002863
PBX: 123708340 123714501
PNAP: 125049648 125059630
ZCE: 119829693 119832290
CCRC: 123694796 123695479
LSIN: 126976424 126979176
AAGE: 121730760 121732263
HAW: 110376532 110377523
HZE: 124633059 124633234
TNL: 113494794 113496714
SLIU: 111353352 111359721
OFU: 114357187 114361976
ONU: 135074714 135075078
ATRA: 106133510 106137062
GMW: 113510542 113518318
PXY: 105393061 119691472 125488587
PGW: 126369271 126372417
LGLY: 125225357 125233047
CSTB: 134744489 134756081
CFUM: 141429275 141438468 141441158
CFEL: 113376318 113377350
API: 100165338 100165639 100573648
DNX: 107163678 107166092
AGS: 114125562
RMD: 113555271 113560575
ACOO: 126837273 126839223
DVT: 126901113
BTAB: 109030166 109030645 109042887
NLU: 111045781 111048849
LDA: 142321460 142322186
HVI: 124355318
PHU: Phum_PHUM399920 Phum_PHUM407830
TPAL: 117642345 117644223 117644227 117644838 117645549 117646570 117647020 117647901 117648133 117650702 117650881 117652427 117653641
ZNE: 110827391 110835653
CSEC: 111866426 111875651
PAME: 138699851(dnk)
SGRE: 126273169
BROR: 134528510
IEL: 124165263
HAMR: 139690882 139700952
FCD: 110842433
DPX: DAPPUDRAFT_305834 DAPPUDRAFT_99663
AFRA: 136043063
PVM: 113818333
PMOO: 119596870
HAME: 121868408
MNZ: 135206122 135213635 135213638
MRJ: 136834051 136840047(SmD2) 136854173
PORN: 139765066
HAZT: 108665785
EAF: 111699873 111704998 111706452 111718376
LSM: 121121677 121122856
TCF: 131878958 131879683 131882528 131885170 131889936
PPOI: 119101655
VDE: 111249878 111253427
VJA: 111260459 111269325
GOE: 100902096 100908739
DPTE: 113789910
DFR: 124499059
PMEO: 129588944 129593989
DPOL: 127865105
VG: 80534602(DNK)
 » show all
Reference
PMID:10692477
  Authors
Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J
  Title
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants.
  Journal
J Biol Chem 275:6673-9 (2000)
DOI:10.1074/jbc.275.9.6673
  Sequence
[dme:Dmel_CG5452]
Reference
PMID:9461577
  Authors
Munch-Petersen B, Piskur J, Sondergaard L.
  Title
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.
  Journal
J Biol Chem 273:3926-31 (1998)
DOI:10.1074/jbc.273.7.3926
  Sequence
[dme:Dmel_CG5452]
LinkDB

KEGG   ENZYME: 2.7.1.145
Entry
EC 2.7.1.145                Enzyme                                 
Name
deoxynucleoside kinase;
multispecific deoxynucleoside kinase;
ms-dNK;
multisubstrate deoxyribonucleoside kinase;
multifunctional deoxynucleoside kinase;
D. melanogaster deoxynucleoside kinase;
Dm-dNK;
ATP:deoxynucleoside 5'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:deoxyribonucleoside 5'-phosphotransferase
Reaction(IUBMB)
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate [RN:R05806]
Reaction(KEGG)
R05806 > R01567 R01666 R01967 R02089 R02099
Substrate
ATP [CPD:C00002];
2'-deoxyribonucleoside [CPD:C02269]
Product
ADP [CPD:C00008];
2'-deoxyribonucleoside 5'-phosphate [CPD:C00676]
Comment
The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common 2'-deoxyribonucleosides.
History
EC 2.7.1.145 created 2001
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K05961  deoxynucleoside kinase
Genes
AAMU: 139934361
DME: Dmel_CG5452(dnk)
DER: 6554072
DSE: 6620705
DSI: Dsimw501_GD19261(Dsim_GD19261)
DYA: Dyak_GE25572
DAN: 6505870
DSR: 110186665
DPO: 4801838
DPE: 6588091
DMN: 108156402
DWI: 6647251
DGR: 6568426
DMO: Dmoj_GI10047
DAZ: 108620993
DNV: 108658836
DHE: 111602690
DVI: 6631195(dnk)
CCAT: 101450470
BOD: 106617808
BDR: 105231069
RZE: 108355448
AOQ: 129236198
ALUD: 128855559
TDA: 119680404 119681378
MDE: 101896877
SCAC: 106090041
LCQ: 111680959
LSQ: 119613191
CVJ: 135956818(dnk)
GFS: 119639424
ECOE: 129942128
CLON: 129605891 129612847
HIS: 119650996
AGA: 1281587
ACOZ: 120953957
AARA: 120898076
AMER: 121590743
ASTE: 118505597 118516567
AMAP: 126558772
AFUN: 125774874
AMOU: 128297035
AMRS: 128719419
AALI: 118461083
ADAR: 125948202
ACOS: 131272495
AAG: 5579214
AALB: 109405935 109417111 115266522
ASUA: 134205313
CQU: CpipJ_CPIJ003276
CPII: 120424947
CBRI: 134834111
CNS: 116347604 116350021 116351806
BCOO: 119069920 119070619 119075577 119079253 119085227
LLL: 129787213
PPAP: 129798829
AME: 552840
ACER: 107998280
ALAB: 122714892
ADR: 102672898
AFLR: 100871899
BIM: 100744576
BBIF: 117205012
BVK: 117230963
BVAN: 117153269
BHUN: 126871547
BTER: 100648317
BAFF: 126921834
BPYO: 122567739
BPAS: 132912725
FVI: 122537787
CCAL: 108626754
OBB: 114878736
OLG: 117602966
MGEN: 117221411
NMEA: 116423874
CGIG: 122398991
SOC: 105196060 105207545
MPHA: 105836053 105837551 118648111
AEC: 105144858 105146649
ACEP: 105623946 105626028
ACOC: 108689658 108693899
MZT: 108727417 108729376(dnk)
CCOA: 108779345 108782953
TCZ: 108757663 108764917
TSEP: 108753333
PBAR: 105422323 105427465
VEM: 105564478 105567866
COBS: 139110032(Dnk) 139111355
TLN: 139821156 139821544(Dnk)
HST: 105187065 105188611
DQU: 106741152 106749991
CFO: 105248838 105257645
FEX: 115238243 115243702
PMEC: 138932778 138940873(Dnk)
LHU: 105672005 105672239
PGC: 109856640 109858340
OBO: 105275914 105281382
PCF: 106784413
PFUC: 122519186
VPS: 122630646
VCRB: 124424167
VVE: 124950789 124950790
LHT: 122513012
LBD: 127284996
FAS: 105270889
DAM: 107041802
AGIF: 122861087
VCAN: 122412197
CCIN: 107262785
DSM: 124410894 124416581
NPT: 124215415(dnk)
NFB: 124179224
NLO: 107219391
NVG: 124300585
AROA: 105684234
TCA: 659303 659935 660567
TMOL: 138134634 138137700 138139629
DPA: 109542197 109546462
ESIM: 136415311 136420060
EFOR: 136340337 136344705
SOY: 115876628 115880872 115880987 115883471
RFG: 143197084 143199011 143206918
AGRG: 126746792 126747076 126747310
ATD: 109602144
CSET: 123319946 123321861
HAXR: 123682104 123685761
AGB: 108907401 108911548 108915258
LDC: 111501828 111511326
DVV: 114326361 126881083
NVL: 108559729 108561321 108567605
APLN: 108736123 108740527
PPYR: 116171896 116172019 116178371 116181669 116182896
OTU: 111416219 111424509 111429051
BMOR: 101741300 692569
BMAN: 114244024 114245792
MSEX: 115448679 115450116
DPL: KGM_201543 KGM_210835
BANY: 112044401 112051943
MJU: 123871697 123871853
NIQ: 126769380 126770645
VCD: 124529800 124532529
MCIX: 123655306 123657209
PMAC: 106707992 106716895
PPOT: 106109692 106111772
PXU: 106121104 106124000
BPHI: 137926499(dnk) 137932423
PRAP: 111000809 111002863
PBX: 123708340 123714501
PNAP: 125049648 125059630
ZCE: 119829693 119832290
CCRC: 123694796 123695479
LSIN: 126976424 126979176
AAGE: 121730760 121732263
HAW: 110376532 110377523
HZE: 124633059 124633234
TNL: 113494794 113496714
SLIU: 111353352 111359721
OFU: 114357187 114361976
ONU: 135074714 135075078
ATRA: 106133510 106137062
GMW: 113510542 113518318
PXY: 105393061 119691472 125488587
PGW: 126369271 126372417
LGLY: 125225357 125233047
CSTB: 134744489 134756081
CFUM: 141429275 141438468 141441158
CFEL: 113376318 113377350
API: 100165338 100165639 100573648
DNX: 107163678 107166092
AGS: 114125562
RMD: 113555271 113560575
ACOO: 126837273 126839223
DVT: 126901113
BTAB: 109030166 109030645 109042887
NLU: 111045781 111048849
LDA: 142321460 142322186
HVI: 124355318
PHU: Phum_PHUM399920 Phum_PHUM407830
TPAL: 117642345 117644223 117644227 117644838 117645549 117646570 117647020 117647901 117648133 117650702 117650881 117652427 117653641
ZNE: 110827391 110835653
CSEC: 111866426 111875651
PAME: 138699851(dnk)
SGRE: 126273169
BROR: 134528510
IEL: 124165263
HAMR: 139690882 139700952
FCD: 110842433
DPX: DAPPUDRAFT_305834 DAPPUDRAFT_99663
AFRA: 136043063
PVM: 113818333
PMOO: 119596870
HAME: 121868408
MNZ: 135206122 135213635 135213638
MRJ: 136834051 136840047(SmD2) 136854173
PORN: 139765066
HAZT: 108665785
EAF: 111699873 111704998 111706452 111718376
LSM: 121121677 121122856
TCF: 131878958 131879683 131882528 131885170 131889936
PPOI: 119101655
VDE: 111249878 111253427
VJA: 111260459 111269325
GOE: 100902096 100908739
DPTE: 113789910
DFR: 124499059
PMEO: 129588944 129593989
DPOL: 127865105
 » show all
Reference
1  [PMID:9461577]
  Authors
Munch-Petersen B, Piskur J, Sondergaard L.
  Title
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase.
  Journal
J Biol Chem 273:3926-31 (1998)
DOI:10.1074/jbc.273.7.3926
  Sequence
[dme:Dmel_CG5452]
Reference
2  [PMID:10692477]
  Authors
Munch-Petersen B, Knecht W, Lenz C, Sondergaard L, Piskur J
  Title
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants.
  Journal
J Biol Chem 275:6673-9 (2000)
DOI:10.1074/jbc.275.9.6673
  Sequence
[dme:Dmel_CG5452]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.145
IUBMB Enzyme Nomenclature: 2.7.1.145
ExPASy - ENZYME nomenclature database: 2.7.1.145
BRENDA, the Enzyme Database: 2.7.1.145
CAS: 52227-81-3
LinkDB

KEGG   REACTION: R02089
Entry
R02089                      Reaction                               
Name
ATP:deoxyadenosine 5'-phosphotransferase
Definition
ATP + Deoxyadenosine <=> ADP + dAMP
Equation
C00002 + C00559 <=> C00008 + C00360
Reaction class
RC00002  C00002_C00008
RC00017  C00360_C00559
Enzyme
2.7.1.76        2.7.1.145
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01232  Nucleotide metabolism
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.76
     R02089  ATP + Deoxyadenosine <=> ADP + dAMP
    2.7.1.145
     R02089  ATP + Deoxyadenosine <=> ADP + dAMP
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.7.1.145
   R05806  Deoxynucleoside <=> Deoxynucleoside 5'-phosphate
    R02089  Deoxyadenosine <=> dAMP
Orthology
K00893  deoxycitidine/deoxyadenosine/deoxyguanosine kinase [EC:2.7.1.74 2.7.1.76 2.7.1.113]
K05961  deoxynucleoside kinase [EC:2.7.1.145]
K10353  deoxyadenosine kinase [EC:2.7.1.76]
K15519  deoxyadenosine/deoxycytidine kinase [EC:2.7.1.76 2.7.1.74]
Other DBs
RHEA: 23455
LinkDB

DBGET integrated database retrieval system