Entry
Name
pyridoxal 5'-phosphate synthase (glutamine hydrolysing);
PdxST
Class
Lyases;
Carbon-nitrogen lyases;
Amine-lyases
BRITE hierarchy
Sysname
D-ribose 5-phosphate,D-glyceraldehyde 3-phosphate pyridoxal 5'-phosphate-lyase
Reaction(IUBMB)
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate (overall reaction) [RN:
R10089 ];
(1a) L-glutamine + H2O = L-glutamate + NH3 [RN:
R00256 ];
(1b) D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate [RN:
R10088 ]
Reaction(KEGG)
Substrate
Product
Comment
The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. The enzyme complex is found in aerobic bacteria, archaea, fungi and plants.
History
EC 4.3.3.6 created 2011
Pathway
Orthology
K06215 pyridoxal 5'-phosphate synthase pdxS subunit
K08681 pyridoxal 5'-phosphate synthase pdxT subunit
Genes
PTEH : 111531896 111534010 113220749 113222271
AJM : 119037467 119038539 119039309 119057980
LGI : LOTGIDRAFT_116826 LOTGIDRAFT_232087
PCAN : 112558919 112558922
MYI : 110441274 110441275 110444099
PMAX : 117335671 117335673
MMER : 123537255 123537257 123545266
AMIL : 114960843 114960865
SPIS : 111331298 111331299
XEN : 124433996 124433997 124433999 124434000
AQU : 100632252 100635319 100641418
ATH : AT2G38230(PDX1.1) AT3G16050(PDX1.2) AT5G01410(RSR4) AT5G60540(PDX2)
ALY : 9298343 9300765 9306992 9315799 9319041
CRB : 17875026 17881905 17888004 17893645
CSAT : 104708991 104726642 104734162 104737989 104745923 104745924 104745925 104745926 104748223 104762162 104765436 104768322 104780857 104782257 104785649 104792621
EUS : EUTSA_v10014160mg EUTSA_v10014179mg EUTSA_v10017969mg EUTSA_v10021182mg
BRP : 103840299 103845470 103850418 103855422 103865657
BNA : 106348515 106365747 106367699 106371607 106376844 106385921 106385965 106405963 106407135 106427315 106433826 106435459 106452459
BOE : 106313498 106316495 106327790 106336166 106342912
RSZ : 108812597 108813613 108814262 108843530 108847216 108855419
THJ : 104810521 104814830 104816195 104823297 104827052
CPAP : 110806448 110820973 110824654
CIT : 102608337 102608556 102609687 102610004 102623292
CIC : CICLE_v10012274mg CICLE_v10026152mg CICLE_v10026215mg CICLE_v10028683mg CICLE_v10029093mg
PVY : 116110609 116110611 116114445 116115159 116129462
MINC : 123201592 123201890 123210316 123212215 123219349 123226053 123226604
TCC : 18590063 18595925 18597542
GRA : 105768688 105768809 105776731 105780038 105786557 105799951
GHI : 107890961 107891550 107897202 107899534 107906513 107906730 107932685 107937078 107941089 107948587 107958060 107959267
GAB : 108450576 108453021 108454459 108460910 108467098 108489420
DZI : 111278930 111295509 111296089 111302020 111302035 111303876 111312048
EGR : 104426376 104432645 104432864 104449870 104449871
GMX : 100776337 100786227 100816306 102667909 732627
GSJ : 114372602 114376383 114387872 114406144 114415849
PVU : PHAVU_006G171100g PHAVU_010G001900g
CCAJ : 109787861 109810140
APRC : 113847965 113849133 113857106
MTR : MTR_2g017520 MTR_4g012860 MTR_4g015590
CAM : 101488342 101488897 101489656
LJA : Lj0g3v0021599.1(Lj0g3v0021599.1) Lj0g3v0021599.2(Lj0g3v0021599.2) Lj3g3v2284470.1(Lj3g3v2284470.1) Lj3g3v2286550.1(Lj3g3v2286550.1) Lj6g3v1967070.1(Lj6g3v1967070.1)
ADU : 107464021 107468166 107475165 107484037
AIP : 107618974 107623360 107625741 107639538
AHF : 112709882 112714405 112727980 112743634 112750237 112775185 112782311 112797014
LANG : 109337906 109338750 109338915 109345235 109361326
FVE : 101293315 101293378 101311692 101313491
RCN : 112168247 112186613 112192678 112201523
PPER : 18772142 18774904 18775539 18784274
PMUM : 103320878 103325150 103327929 103341908
PAVI : 110747844 110758692 110769513 110770492 110771339
PDUL : 117623218 117629538 117632058 117633208 117633236
MDM : 103405472 103422086 103433606 103434771 103446070 103447388 103447873 103452951
PXB : 103927836 103930634 103937773 103938933 103944875 103966330
ZJU : 107404983 107405421 107410863 107411338 107430846
MNT : 21391064 21404838 21408857
CSV : 101212698 101213282 101214331 101219485
CMO : 103486294 103500799 103501941 103502019
BHJ : 120085236 120087567 120088392 120090175
MCHA : 111011333 111014984 111015088
CMAX : 111470122 111481529 111483918 111484507 111494636
CMOS : 111441643 111448464 111448973 111452310 111459428 111464308
CPEP : 111776766 111777217 111779186 111786771 111790758 111796024 111799973
RCU : 8263150 8265048 8274511 8286459
JCU : 105628108 105630332 105634984 105646590
HBR : 110632009 110634814 110636500 110638844 110645311 110645679 110651713 110654538 110662115
MESC : 110612502 110613092 110613697 110623171 110625551
POP : 7468053 7470551 7487474 7491139
PEU : 105112531 105113209 105116000 105121938 105139585
PALZ : 118034735 118037474 118046185 118048433
JRE : 108982999 108990135 109002194
QSU : 111994554 112002014 112017428 112018845 112031404 112035279
QLO : 115983617 115989616 115991722
TWL : 119990761 119998848 120001538 120002330 120005980 120011245 120011777
VVI : 100242970 100260451 100267348
VRI : 117916727 117916825 117921535
SLY : 101251664 101254971 101257782
SPEN : 107004499 107012142 107023284
SOT : 102588309 102590002 102605133
CANN : 107848336 107853207 107861876 107875470 107875578
NTA : 107760531(Pdx2) 107769831 107780413 107800120 107805188 107807313(Pdx1-A) 107819695
NSY : 104216665 104242733 104246086
NTO : 104088338 104094417 104100375
NAU : 109215916 109220116 109240102
INI : 109163422 109173631 109188292 109193010
ITR : 116003584 116010162 116016261 116016337
SIND : 105163948 105163962 105170308
OEU : 111369686 111369930 111370599 111403541 111403542 111405142 111407755
EGT : 105949208 105949211 105959706 105972408
SSPL : 121743541 121744020 121749762 121780446 121782705 121787424 121789419 121811520
HAN : 110865490 110874405 110879833 110880108 110904586
ECAD : 122581147 122581820 122592602 122595746
LSV : 111881071 111881704 111886778 111887922 111910262
CCAV : 112506777 112510525 112512096 112512245 112512246 112513695 112516660 112520500
DCR : 108193339 108196602 108197388 108205951 108206088
CSIN : 114283830 114296850 114308164 114308650 114318586
BVG : 104899952 104903251 104904673
SOE : 110786616 110797904 110803010
CQI : 110683465 110688258 110695399 110703356 110712019 110738003
NNU : 104592217 104594827 104595045 104602639
MING : 122058401 122062409 122085842 122091832
TSS : 122656734 122657076 122670418 122671441
PSOM : 113299841 113303772 113307730 113308323 113322898 113338728
NCOL : 116250345 116256064
OSA : 107279054 4328188 4342162 4347937
DOSA : Os02t0130100-01(Os02g0130100) Os07t0100200-01(Os07g0100200) Os10t0100700-01(Os10g0100700) Os10t0191600-00(Os10g0191600) Os11t0708500-01(Os11g0708500)
OBR : 102704916 102709325 102709946 102710219 102719359 121054887
BDI : 100826362 100837310 100842485 100842713
ATS : 109731717 109757789 109766728 109771478
TDC : 119284573 119286116 119291601 119295686 119314836 119323570 119354793 119363955
TAES : 123045174 123053005 123084744 123091732 123093346 123096716 123100318 123131982 123136058 123143509 123188919 778399
ZMA : 100272732 100280630 100280887(SMK2)
SITA : 101764753 101780240 101785955
SVS : 117833862 117841423 117843457
PVIR : 120645331 120654552 120659653 120685277 120687270 120711832
PHAI : 112880616 112883159 112902765
PDA : 103697103 103697943 103708291 120104088 120105367
EGU : 105035764 105035898 105050909
MUS : 103972766 103974794 103990383 103995741 103997631
DCT : 110095226 110099233 110108833 110112870
PEQ : 110017847 110022499 110038299
SMO : SELMODRAFT_146305 SELMODRAFT_165081 SELMODRAFT_167143 SELMODRAFT_182665
PPP : 112278226 112282990 112284132 112293736 112295106 112295839
CRE : CHLRE_03g167051v5 CHLRE_15g643550v5
VCN : VOLCADRAFT_109832 VOLCADRAFT_66485
MNG : MNEG_14628 MNEG_5303
CVR : CHLNCDRAFT_11969 CHLNCDRAFT_55943
APRO : F751_0682 F751_4075
OLU : OSTLU_45279 OSTLU_7092
OTA : OT_ostta03g00220 OT_ostta17g02360
BPG : Bathy12g00180 Bathy14g00060
MIS : MICPUN_107893 MICPUN_90898
MPP : MICPUCDRAFT_23003 MICPUCDRAFT_24622
CME : CYME_CMP070C CYME_CMR368C
GSL : Gasu_12160 Gasu_54240
CCP : CHC_T00000298001 CHC_T00008684001
SCE : YFL059W(SNZ3) YFL060C(SNO3) YMR095C(SNO1) YMR096W(SNZ1) YNL333W(SNZ2) YNL334C(SNO2)
AGO : AGOS_ABR122C AGOS_ABR123W
KLA : KLLA0_A00352g KLLA0_A00374g
KMX : KLMA_30724(SNZ3) KLMA_30726(SNO3)