KEGG   ORTHOLOGY: K06269
Entry
K06269                      KO                                     
Symbol
PPP1C
Name
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Pathway
map03015  mRNA surveillance pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04113  Meiosis - yeast
map04114  Oocyte meiosis
map04218  Cellular senescence
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04390  Hippo signaling pathway
map04510  Focal adhesion
map04611  Platelet activation
map04720  Long-term potentiation
map04728  Dopaminergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04921  Oxytocin signaling pathway
map04931  Insulin resistance
map05031  Amphetamine addiction
map05034  Alcoholism
map05168  Herpes simplex virus 1 infection
map05205  Proteoglycans in cancer
map05415  Diabetic cardiomyopathy
Disease
H00523  Noonan syndrome and related disorders
H02191  Noonan-like syndrome with loose anagen hair
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04024 cAMP signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04022 cGMP-PKG signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09140 Cellular Processes
  09143 Cell growth and death
   04113 Meiosis - yeast
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04114 Oocyte meiosis
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04218 Cellular senescence
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04921 Oxytocin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04270 Vascular smooth muscle contraction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09156 Nervous system
   04728 Dopaminergic synapse
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04720 Long-term potentiation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09165 Substance dependence
   05031 Amphetamine addiction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   05034 Alcoholism
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   03019 Messenger RNA biogenesis
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   03041 Spliceosome
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Transcription machinery [BR:ko03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Spliceosome [BR:ko03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Other DBs
COG: COG0639
GO: 0004722
Genes
HSA: 5499(PPP1CA) 5500(PPP1CB) 5501(PPP1CC)
PTR: 459118(PPP1CB) 462795(PPP1CC) 743656 745709(PPP1CA)
PPS: 100967456 100974889(PPP1CC) 100978326(PPP1CB) 100992486(PPP1CA)
GGO: 101129953(PPP1CB) 101143438(PPP1CC)
PON: 100173410(PPP1CB) 100458223(PPP1CC) 100459799(PPP1CA)
NLE: 100587142(PPP1CB) 100603005(PPP1CA) 100605408(PPP1CC)
MCC: 703302(PPP1CB) 709935(PPP1CC) 721735(PPP1CA)
MCF: 101925057(PPP1CC) 102133300(PPP1CB) 102138402(PPP1CA)
CSAB: 103218909(PPP1CA) 103220572(PPP1CB) 103239526(PPP1CC)
CATY: 105573406(PPP1CC) 105577361(PPP1CA) 105578430(PPP1CB)
PANU: 101014342(PPP1CA) 101016118(PPP1CB) 101025668(PPP1CC)
TGE: 112604670 112606994(PPP1CA) 112634287(PPP1CC) 112636950(PPP1CB)
RRO: 104664823(PPP1CA) 104668466(PPP1CB) 104675136(PPP1CC)
RBB: 108512265(PPP1CC) 108518604(PPP1CA) 108532746(PPP1CB)
TFN: 117062530(PPP1CB) 117080254(PPP1CA) 117089406(PPP1CC) 117095609
PTEH: 111522255(PPP1CA) 111532210 111536803(PPP1CC) 111546019(PPP1CB)
SBQ: 101030626 101048398(PPP1CB) 101048497(PPP1CA) 101050671(PPP1CC)
CSYR: 103250671(PPP1CA) 103251817(PPP1CB) 103252205 103262486(PPP1CC)
MMUR: 105856600 105867474(PPP1CA) 105868044 105880930(PPP1CC) 105884438(PPP1CB)
OGA: 100941909(PPP1CA) 100945379 100960152(PPP1CB)
MMU: 19045(Ppp1ca) 19046(Ppp1cb) 19047(Ppp1cc) 434233(Ppp1ccb)
MCAL: 110285541(Ppp1ca) 110288037 110294013(Ppp1cb) 110294931(Ppp1cc)
MPAH: 110312794(Ppp1cc) 110317198(Ppp1ca) 110324329(Ppp1cb)
RNO: 100363225 24668(Ppp1ca) 24669(Ppp1cc) 25594(Ppp1cb)
MCOC: 116079614(Ppp1cb) 116103326(Ppp1ca) 116104637(Ppp1cc)
MUN: 110545313(Ppp1cc) 110554524(Ppp1cb) 110560352(Ppp1ca)
CGE: 100760810(Ppp1ca) 100761524(Ppp1cb) 100774547(Ppp1cc)
PLEU: 114683953 114685987(Ppp1ca) 114696284(Ppp1cb) 114704570(Ppp1cc)
NGI: 103725581(Ppp1ca) 103730228(Ppp1cb) 103739088(Ppp1cc)
HGL: 101698044(Ppp1cb) 101705408(Ppp1ca) 101714468(Ppp1cc)
CPOC: 100721697(Ppp1ca) 100728198(Ppp1cc) 100730372(Ppp1cb)
CCAN: 109679334(Ppp1cb) 109685544 109688628(Ppp1ca)
DORD: 105983690(Ppp1cb) 105989189(Ppp1ca) 105990644(Ppp1cc)
DSP: 122098491(Ppp1cc) 122104673(Ppp1ca) 122122432(Ppp1cb)
OCU: 100009298(PPP1CA) 100009587(PPP1CB) 100353054(PPP1CC)
OPI: 101522201(PPP1CB) 101525073(PPP1CA) 101533284(PPP1CC)
TUP: 102469176 102476316(PPP1CC) 102477186(PPP1CA) 102496931(PPP1CB)
CFA: 403557(PPP1CC) 403558(PPP1CB) 403609(PPP1CA)
VVP: 112924187(PPP1CA) 112933024(PPP1CB) 112935190(PPP1CC)
VLG: 121472051(PPP1CA) 121475295(PPP1CC) 121491037(PPP1CB)
AML: 100464499(PPP1CA) 100471456(PPP1CB) 100476029(PPP1CC)
UMR: 103661277(PPP1CC) 103671909(PPP1CB) 103679611(PPP1CA)
UAH: 113240761(PPP1CB) 113244033(PPP1CA) 113266966(PPP1CC)
UAR: 123778467(PPP1CA) 123779126(PPP1CC) 123795174 123799882(PPP1CB)
MPUF: 101670225(PPP1CC) 101678969(PPP1CB) 101694049(PPP1CA)
ORO: 101372346(PPP1CB) 101382867(PPP1CA) 101386053(PPP1CC)
EJU: 114205825(PPP1CB) 114219135(PPP1CC) 114220523(PPP1CA)
ZCA: 113912840(PPP1CC) 113914784(PPP1CA) 113937582(PPP1CB)
MLX: 118007723(PPP1CB) 118016125(PPP1CA) 118018468(PPP1CC)
FCA: 101092932(PPP1CB) 101100922(PPP1CC) 109492306(PPP1CA)
PYU: 121010340(PPP1CC) 121023688(PPP1CA) 121044291(PPP1CB)
PBG: 122470216(PPP1CC) 122484053(PPP1CA) 122497307(PPP1CB)
PTG: 102948702(PPP1CC) 102970154(PPP1CB) 107180886(PPP1CA)
PPAD: 109246846(PPP1CA) 109266491(PPP1CB) 109277658(PPP1CC)
AJU: 106967586(PPP1CC) 106967920(PPP1CB) 106971182(PPP1CA)
HHV: 120233909(PPP1CA) 120235890(PPP1CB) 120239251(PPP1CC)
BTA: 282318(PPP1CC) 516175(PPP1CA) 538829(PPP1CB)
BOM: 102266876(PPP1CB) 102270793(PPP1CA) 102275429(PPP1CC)
BIU: 109554414(PPP1CA) 109566263(PPP1CB) 109571193(PPP1CC)
BBUB: 102393123(PPP1CC) 102395266(PPP1CA) 102396799(PPP1CB)
CHX: 102170985(PPP1CB) 102181064(PPP1CC) 102181571(PPP1CA)
OAS: 101106284(PPP1CC) 101119264(PPP1CA) 101123197(PPP1CB) 114118855
ODA: 120851530(PPP1CB) 120871062(PPP1CC) 120874772(PPP1CA)
CCAD: 122423576(PPP1CC) 122430818(PPP1CA) 122435753 122440096 122441910(PPP1CB)
SSC: 397378(PPP1CB) 733611(PPP1CA) 733612(PPP1CC)
CFR: 102505354(PPP1CA) 102520782(PPP1CB) 102522874(PPP1CC)
CBAI: 105063807(PPP1CB) 105070330(PPP1CA) 105080605(PPP1CC)
CDK: 105098564(PPP1CB) 105102484(PPP1CC) 105104430(PPP1CA)
BACU: 103000500(PPP1CB) 103008250 103008309(PPP1CA) 103017316(PPP1CC)
LVE: 103072994(PPP1CC) 103074387(PPP1CA) 103080471(PPP1CB) 103086084
OOR: 101280558(PPP1CB) 101285623(PPP1CA) 101286983(PPP1CC)
DLE: 111174925(PPP1CB) 111183676(PPP1CA) 111186906(PPP1CC)
PCAD: 102981359(PPP1CC) 102981740(PPP1CA) 102992996(PPP1CB)
PSIU: 116739009(PPP1CC) 116757793(PPP1CA) 116764122(PPP1CB)
ECB: 100058160(PPP1CC) 100059233(PPP1CA) 100071067(PPP1CB)
EPZ: 103541647(PPP1CC) 103549472(PPP1CB) 103560150(PPP1CA)
EAI: 106833503(PPP1CA) 106837075 106842216(PPP1CC)
MYB: 102239740(PPP1CC) 102244214(PPP1CA) 102248545(PPP1CB) 102253559
MYD: 102760260(PPP1CB) 102764391(PPP1CA) 102775047
MMYO: 118665223(PPP1CA) 118666814 118669147(PPP1CB) 118678222(PPP1CC)
MLF: 102417633(PPP1CC) 102429857(PPP1CA) 102436383 102437203(PPP1CB)
MNA: 107529564(PPP1CC) 107533957 107534692(PPP1CB)
PKL: 118706953(PPP1CA) 118716639 118717159(PPP1CB) 118725464(PPP1CC)
HAI: 109384139(PPP1CA) 109385685(PPP1CB) 109386108(PPP1CC)
DRO: 112297802(PPP1CB) 112310655(PPP1CC) 112317227(PPP1CA)
SHON: 118991095(PPP1CC) 118991813(PPP1CA) 119001313(PPP1CB)
AJM: 119040451(PPP1CC) 119041883(PPP1CA) 119050357(PPP1CB) 119055613
PDIC: 114499392(PPP1CA) 114501023(PPP1CB) 114509175(PPP1CC)
PHAS: 123821109(PPP1CC) 123822478(PPP1CB) 123829523(PPP1CA)
MMF: 118627965(PPP1CA) 118630486(PPP1CB) 118639818(PPP1CC)
RFQ: 117017501(PPP1CC) 117029941(PPP1CA) 117032986(PPP1CB)
PALE: 102881448(PPP1CB) 102887827(PPP1CC) 102892254(PPP1CA)
PGIG: 120584763(PPP1CA) 120616096(PPP1CC) 120621819(PPP1CB)
PVP: 105289220(PPP1CC) 105299132(PPP1CB) 105309924(PPP1CA)
RAY: 107503728(PPP1CA) 107511165(PPP1CB) 107513247(PPP1CC)
MJV: 108393155(PPP1CA) 108400557(PPP1CC) 108407321(PPP1CB)
TOD: 119244989(PPP1CC) 119249914(PPP1CA) 119259438(PPP1CB)
SARA: 101536910 101538700 101548002(PPP1CB) 101551866(PPP1CA)
LAV: 100660199(PPP1CB) 100671604(PPP1CC) 100673814(PPP1CA)
DNM: 101440357(PPP1CC) 101441254(PPP1CB) 101444762(PPP1CA)
MDO: 100019898(PPP1CC) 100029055(PPP1CA) 100031298(PPP1CB)
GAS: 123237064(PPP1CB) 123244865(PPP1CC) 123252171(PPP1CA) 123252806
SHR: 100915116(PPP1CA) 100920526(PPP1CC) 100930570(PPP1CB)
PCW: 110195486(PPP1CA) 110196829(PPP1CC) 110206445(PPP1CB)
OAA: 100074395(PPP1CC) 100078635(PPP1CB) 100092226(PPP1CA)
GGA: 100858156(PPP1CA) 396019(PPP1CB) 416872(PPP1CC)
PCOC: 116228591(PPP1CC) 116229780(PPP1CB) 116243020(PPP1CA)
MGP: 100544698(PPP1CB) 100546973(PPP1CC) 100550782(PPP1CA)
CJO: 107311180(PPP1CB) 107314245(PPP1CA) 107321188(PPP1CC)
NMEL: 110396314(PPP1CB) 110400859(PPP1CA) 110406337(PPP1CC)
APLA: 101798783(PPP1CB)
ACYG: 106029776(PPP1CB) 106031410(PPP1CC)
AFUL: 116487559(PPP1CB) 116490257(PPP1CA) 116495978(PPP1CC)
TGU: 100190013(PPP1CA) 100190751(PPP1CC) 100224238(PPP1CB)
LSR: 110478165(PPP1CC) 110482805(PPP1CB) 110485072(PPP1CA)
SCAN: 103817249(PPP1CB) 103818147(PPP1CC) 103822255(PPP1CA)
PMOA: 120496922(PPP1CB) 120499583(PPP1CA) 120509664(PPP1CC)
OTC: 121338915(PPP1CC) 121339690(PPP1CA) 121340629(PPP1CB)
PRUF: 121355156(PPP1CA) 121358769(PPP1CB) 121364966(PPP1CC)
GFR: 102032151(PPP1CB) 102039437(PPP1CA) 102042078(PPP1CC)
FAB: 101810420(PPP1CA) 101813100(PPP1CB) 107603979(PPP1CC)
PHI: 102099963(PPP1CA) 102101654(PPP1CC) 102114757(PPP1CB)
PMAJ: 107201313(PPP1CB) 107205266(PPP1CA) 107211824(PPP1CC)
CCAE: 111927633(PPP1CB) 111936713(PPP1CC)
CCW: 104684134(PPP1CA) 104685699(PPP1CB) 104688680(PPP1CC)
ETL: 114055006(PPP1CC) 114063365(PPP1CA) 114064849(PPP1CB)
ZAB: 102067002(PPP1CB) 102072312(PPP1CC) 102073093(PPP1CA)
FPG: 101913968(PPP1CA) 101916649(PPP1CB) 101924787(PPP1CC)
FCH: 102053170(PPP1CA) 102054093 102058478(PPP1CB)
CLV: 102083732(PPP1CB) 102086082(PPP1CC) 102096027(PPP1CA)
EGZ: 104122715(PPP1CC) 104135633(PPP1CB)
NNI: 104011867(PPP1CA) 104020653(PPP1CC) 104021492(PPP1CB)
ACUN: 113478943(PPP1CB) 113486130(PPP1CC)
TALA: 104359497(PPP1CC) 104360335(PPP1CB) 104363002(PPP1CA)
PADL: 103914295(PPP1CB) 103914541(PPP1CC)
ACHC: 115337541(PPP1CA) 115346179(PPP1CC) 115350480(PPP1CB)
AAM: 106485498(PPP1CB) 106495691(PPP1CC) 106495808
AROW: 112962507(PPP1CC) 112962905(PPP1CB) 112967082(PPP1CA)
NPD: 112949378(PPP1CC) 112953209(PPP1CB) 112957826(PPP1CA)
DNE: 112988649(PPP1CA) 112991779(PPP1CC) 112995931(PPP1CB)
ASN: 102373171(PPP1CA) 102375415(PPP1CC) 102383008(PPP1CB)
AMJ: 102560817(PPP1CB) 102564750(PPP1CC) 102565419(PPP1CA)
CPOO: 109319809(PPP1CB) 109324600 109324617(PPP1CA)
GGN: 109290573(PPP1CC) 109304465(PPP1CB)
PSS: 102449920 102450584(PPP1CC) 102463695(PPP1CA) 102463789(PPP1CB)
CMY: 102929648(PPP1CB) 102931057(PPP1CA) 102937166 102937635(PPP1CC)
CPIC: 101931881(PPP1CC) 101942402 101946001(PPP1CB) 101948239(PPP1CA)
TST: 117874543(PPP1CB) 117876562(PPP1CA) 117888092(PPP1CC) 117889275
CABI: 116830629(PPP1CB) 116833423(PPP1CA) 116836730(PPP1CC)
MRV: 120386222(PPP1CC) 120393418(PPP1CA) 120401017(PPP1CB)
ACS: 100552053(ppp1cb) 100558590(ppp1ca) 100565990(ppp1cc)
PVT: 110078692(PPP1CB) 110083839(PPP1CC) 110085633(PPP1CA)
SUND: 121916397(PPP1CC) 121919527(PPP1CA) 121928727(PPP1CB)
PBI: 103056218(PPP1CC) 103057409(PPP1CA) 103062218(PPP1CB)
PMUR: 107286959(PPP1CC) 107298021(PPP1CB) 107302715(PPP1CA)
TSR: 106538243(PPP1CB) 106547126(PPP1CA) 106548633
PGUT: 117671800(PPP1CB) 117672240(PPP1CC) 117675344(PPP1CA)
VKO: 123022913 123027483(PPP1CA) 123027975(PPP1CB) 123028651(PPP1CC)
PMUA: 114594578 114594579 114602049(PPP1CA) 114602733(PPP1CC)
ZVI: 118083253(PPP1CB) 118086298(PPP1CC) 118090240(PPP1CA)
GJA: 107112146(PPP1CC) 107124492(PPP1CB)
XLA: 108704179 108717671(ppp1cb.S) 379914(ppp1ca.L) 380598(ppp1cc.S) 397767(ppp1cc.L) 443852(ppp1cb.L)
XTR: 100145598(ppp1ca) 407879(ppp1cc) 496958(ppp1cb)
NPR: 108786345(PPP1CB) 108788527(PPP1CC) 108796512
RTEM: 120933345(PPP1CC) 120938146(PPP1CB) 120943131
BBUF: 120988566(PPP1CC) 120999647(PPP1CB) 121007488
BGAR: 122924555(PPP1CC) 122933978(PPP1CB) 122944949
DRE: 100003223(ppp1cb) 327301(ppp1cab) 334597(ppp1cbl) 407980(ppp1caa) 571753(ppp1cc)
IPU: 100528446(pp1b) 108259981(ppp1cc) 108269700(ppp1cb) 108274218 108280818(ppp1caa) 108280923
SMEO: 124378916(ppp1cc) 124381499 124389092(ppp1cab) 124390126(ppp1cb) 124396789(ppp1caa)
CGOB: 115014063(ppp1cc) 115023613 115024308 115027034(ppp1cb)
ELY: 117246188 117247036(ppp1cab) 117253113(ppp1cc) 117267401 117268590(ppp1caa) 117270724
PLEP: 121944027(ppp1cc) 121953625 121955123 121956454(ppp1caa) 121958438(ppp1cab) 121961997
SLUC: 116036060 116051660(ppp1cc) 116057556 116061060(ppp1cab) 116063908(ppp1caa) 116066279
ECRA: 117934824 117936151 117937322(ppp1cab) 117944293(ppp1cc) 117957592(ppp1caa) 117961634
GAT: 120807780 120819119(ppp1cab) 120821329 120828502(ppp1caa) 120831365(ppp1cc) 120832967
MSAM: 119892165(ppp1cc) 119893886(ppp1caa) 119908532 119910321 119911846 119915534(ppp1cab)
CUD: 121504511 121510019(ppp1cc) 121521433 121526213 121528070(ppp1cab) 121529429(ppp1caa)
OAU: 116312749 116322661(ppp1cc) 116326054 116327630(ppp1cab) 116328917(ppp1caa) 116335818
OML: 112146006(ppp1caa) 112147529(ppp1cb) 112148595 112154198(ppp1cab) 112156029
CTUL: 119772148 119775196 119791293(ppp1caa) 119795597(ppp1cc) 119798206(ppp1cab)
KMR: 108233480 108235012(ppp1cc) 108237541 108237801(ppp1caa) 108239401 108247904(ppp1cab)
NWH: 119408360 119414132(ppp1cc) 119418592 119421853(ppp1caa) 119423989(ppp1cab) 119427307
SSEN: 122759222(ppp1cab) 122760207 122765921 122766757(ppp1caa) 122769805 122783022(ppp1cb)
HHIP: 117751801 117752749(ppp1cab) 117755516 117758526 117766844(ppp1caa) 117768198(ppp1cc)
XGL: 120785759(ppp1caa) 120788951 120794179(ppp1cab) 120795095 120797028 120805583(ppp1cc)
LOC: 102683699(ppp1cb) 102696354 102699172(ppp1cc)
LCM: 102359594 102359947(PPP1CB) 102361180(PPP1CA) 102361284 102362859(PPP1CC)
CMK: 103184322(ppp1cc) 103189617(ppp1cb)
RTP: 109910556(ppp1cb) 109935119(ppp1cc)
SCLV: 120345949
DME: Dmel_CG10138(PpD5) Dmel_CG10930(PpY-55A) Dmel_CG2096(flw) Dmel_CG3245(PpN58A) Dmel_CG40448(Pp1-Y2) Dmel_CG41534(Pp1-Y1) Dmel_CG5650(Pp1-87B) Dmel_CG6593(Pp1alpha-96A) Dmel_CG8822(PpD6) Dmel_CG9156(Pp1-13C)
DSI: Dsimw501_GD15211(Dsim_GD15211) Dsimw501_GD15806(Dsim_GD15806) Dsimw501_GD16975(Dsim_GD16975) Dsimw501_GD20567(Dsim_GD20567) Dsimw501_GD21106(Dsim_GD21106) Dsimw501_GD23208(Dsim_GD23208) Dsimw501_GD25158(Dsim_GD25158) Dsimw501_GD25428(Dsim_GD25428)
ACEP: 105617778
HAZT: 108674580
DFR: 124492983
CEL: CELE_C05A2.1(pph-1) CELE_C09H5.7(C09H5.7) CELE_C34D4.2(C34D4.2) CELE_F29F11.6(gsp-1) CELE_F52H3.6(F52H3.6) CELE_F56C9.1(gsp-2) CELE_T03F1.5(gsp-4) CELE_T16G12.7(T16G12.7) CELE_W09C3.6(gsp-3) CELE_ZK938.1(ZK938.1)
BMY: BM_BM10090(Bm10090) BM_BM12493(Bm12493) BM_BM18176(Bm18176) BM_BM2117(Bm2117) BM_BM3699(Bma-gsp-1) BM_BM3957(Bm3957) BM_BM4031(Bm4031) BM_BM4558(Bm4558) BM_BM5508(Bm5508) BM_BM6157(Bma-gsp-2) BM_BM6763(Bm6763) BM_BM7394(Bm7394) BM_BM9975(Bm9975)
ATH: AT1G64040(TOPP3) AT2G29400(TOPP1) AT2G39840(TOPP4) AT3G05580(TOPP9) AT3G46820(TOPP5) AT4G11240(TOPP7) AT5G27840(TOPP8) AT5G43380(TOPP6) AT5G59160(TOPP2)
LJA: Lj0g3v0300529.1(Lj0g3v0300529.1) Lj1g3v4918780.1(Lj1g3v4918780.1) Lj2g3v2661450.1(Lj2g3v2661450.1) Lj4g3v2991200.1(Lj4g3v2991200.1) Lj5g3v1170950.1(Lj5g3v1170950.1) Lj5g3v1341890.1(Lj5g3v1341890.1)
DOSA: Os01t0349400-01(Os01g0349400) Os02t0820000-01(Os02g0820000) Os03t0268000-01(Os03g0268000) Os06t0164100-02(Os06g0164100) Os08t0455600-01(Os08g0455600)
MNG: MNEG_1738
APRO: F751_2630
MIS: MICPUN_104871(PP1)
SCE: YDR436W(PPZ2) YER133W(GLC7) YML016C(PPZ1) YPL179W(PPQ1)
KMX: KLMA_30142(GLC7) KLMA_30328(PPQ1) KLMA_40596(PPZ1)
NCS: NCAS_0B04450(NCAS0B04450) NCAS_0H01100(NCAS0H01100) NCAS_0H02660(NCAS0H02660)
NDI: NDAI_0B01900(NDAI0B01900) NDAI_0C00960(NDAI0C00960) NDAI_0F02190(NDAI0F02190)
TPF: TPHA_0D02470(TPHA0D02470) TPHA_0H00280(TPHA0H00280) TPHA_0K00420(TPHA0K00420) TPHA_0N01200(TPHA0N01200)
TBL: TBLA_0A06980(TBLA0A06980) TBLA_0A08840(TBLA0A08840) TBLA_0B05260(TBLA0B05260) TBLA_0D01510(TBLA0D01510)
TDL: TDEL_0A04110(TDEL0A04110) TDEL_0B04530(TDEL0B04530) TDEL_0F01790(TDEL0F01790)
KAF: KAFR_0B02190(KAFR0B02190) KAFR_0C05490(KAFR0C05490) KAFR_0G03660(KAFR0G03660)
SLB: AWJ20_1480(PPZ1) AWJ20_1973(GLC7) AWJ20_1974(GLC7) AWJ20_2933(PPZ1)
NCR: NCU00043(pph-3) NCU07489(pzl-1)
NTE: NEUTE1DRAFT116927(NEUTE1DRAFT_116927) NEUTE1DRAFT70184(NEUTE1DRAFT_70184)
ANG: ANI_1_1062064(An07g08600) ANI_1_1610104(An12g02980) ANI_1_2466014(An01g04120)
ALUC: AKAW2_11423S(PZH1) AKAW2_20556A(PP1) AKAW2_81231S(PPH3)
ACHE: ACHE_11679A(PP1_1) ACHE_31183S(PP1_2) ACHE_70837S(PZH1)
APUU: APUU_11652A(PP1) APUU_40605A(PZH1)
SPO: SPAC57A7.08(pzh1) SPBC776.02c(dis2) SPCC31H12.05c(sds21)
ABP: AGABI1DRAFT117366(AGABI1DRAFT_117366) AGABI1DRAFT86604(AGABI1DRAFT_86604)
ABV: AGABI2DRAFT147675(AGABI2DRAFT_147675) AGABI2DRAFT152533(AGABI2DRAFT_152533)
DDI: DDB_G0275619(pppB)
DFA: DFA_09009(pppB)
EHI: EHI_045530(78.t00036) EHI_048970(184.t00018) EHI_067900(8.t00054) EHI_097970(185.t00009) EHI_176170(156.t00006)
PCB: PCHAS_102910(PC302339.00.0)
TAN: TA12680
TPV: TP02_0350
BBO: BBOV_III006130(17.m07543)
CPV: cgd7_2670
SMIN: v1.2.001664.t1(symbB.v1.2.001664.t1) v1.2.001666.t1(symbB.v1.2.001666.t1) v1.2.006043.t1(symbB.v1.2.006043.t1) v1.2.018377.t1(symbB.v1.2.018377.t1) v1.2.018377.t2(symbB.v1.2.018377.t2) v1.2.025541.t1(symbB.v1.2.025541.t1) v1.2.028716.t1(symbB.v1.2.028716.t1) v1.2.028944.t1(symbB.v1.2.028944.t1) v1.2.036995.t1(symbB.v1.2.036995.t1)
VG: 20041718(JO84_gp297)
 » show all
Reference
PMID:8392016
  Authors
Song Q, Khanna KK, Lu H, Lavin MF
  Title
Cloning and characterization of a human protein phosphatase 1-encoding cDNA.
  Journal
Gene 129:291-5 (1993)
DOI:10.1016/0378-1119(93)90282-8
  Sequence
[hsa:5499]
Reference
  Authors
Lee JH, You J, Dobrota E, Skalnik DG
  Title
Identification and characterization of a novel human PP1 phosphatase complex.
  Journal
J Biol Chem 285:24466-76 (2010)
DOI:10.1074/jbc.M110.109801
  Sequence
[hsa:5499 5500 5501]
LinkDB

KEGG   ORTHOLOGY: K06270
Entry
K06270                      KO                                     
Symbol
PPP1R12A, MYPT1
Name
protein phosphatase 1 regulatory subunit 12A
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04270  Vascular smooth muscle contraction
map04510  Focal adhesion
map04611  Platelet activation
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map05205  Proteoglycans in cancer
Disease
H02523  Genitourinary and brain malformation syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
   04022 cGMP-PKG signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Genes
HSA: 4659(PPP1R12A)
PTR: 452095(PPP1R12A)
PPS: 100989468(PPP1R12A)
GGO: 101139376(PPP1R12A)
PON: 100172617(PPP1R12A)
NLE: 100602476(PPP1R12A)
MCC: 695735(PPP1R12A)
MCF: 101864805(PPP1R12A)
CSAB: 103238782(PPP1R12A)
CATY: 105581076(PPP1R12A)
PANU: 101021299(PPP1R12A)
TGE: 112633984(PPP1R12A)
RRO: 104675773(PPP1R12A)
RBB: 108528527(PPP1R12A)
TFN: 117089688(PPP1R12A)
PTEH: 111547177(PPP1R12A)
CJC: 100393191(PPP1R12A)
SBQ: 101034840(PPP1R12A)
CSYR: 103258562(PPP1R12A)
MMUR: 105863369(PPP1R12A)
OGA: 100955707(PPP1R12A)
MMU: 17931(Ppp1r12a)
MCAL: 110302933(Ppp1r12a)
MPAH: 110326185(Ppp1r12a)
RNO: 116670(Ppp1r12a)
MCOC: 116076104(Ppp1r12a)
MUN: 110558205(Ppp1r12a)
CGE: 100754718(Ppp1r12a)
PLEU: 114695636(Ppp1r12a)
NGI: 103749250(Ppp1r12a)
HGL: 101700150(Ppp1r12a)
CPOC: 100727982(Ppp1r12a)
CCAN: 109697808(Ppp1r12a)
DORD: 105987486(Ppp1r12a)
DSP: 122124417(Ppp1r12a)
OCU: 100350558(PPP1R12A)
OPI: 101529033(PPP1R12A)
TUP: 102473894(PPP1R12A)
CFA: 475411(PPP1R12A)
VVP: 112914878(PPP1R12A)
VLG: 121480949(PPP1R12A)
AML: 100483995(PPP1R12A)
UMR: 103680852(PPP1R12A)
UAH: 113256222(PPP1R12A)
UAR: 123780848(PPP1R12A)
ELK: 111141992
MPUF: 101684983(PPP1R12A)
ORO: 101384536(PPP1R12A)
EJU: 114211055(PPP1R12A)
ZCA: 113921641(PPP1R12A)
MLX: 118008531(PPP1R12A)
FCA: 101089624(PPP1R12A)
PYU: 121040701(PPP1R12A)
PBG: 122472249(PPP1R12A)
PTG: 102951696(PPP1R12A)
PPAD: 109270552(PPP1R12A)
AJU: 106967400(PPP1R12A)
HHV: 120233963(PPP1R12A)
BTA: 538606(PPP1R12A)
BOM: 102268036(PPP1R12A)
BIU: 109558936(PPP1R12A)
BBUB: 102395084(PPP1R12A)
CHX: 102183294(PPP1R12A)
OAS: 641303(PPP1R12A)
ODA: 120858445(PPP1R12A)
CCAD: 122427569(PPP1R12A)
SSC: 397190(PPP1R12A)
CFR: 102511361(PPP1R12A)
CBAI: 105072021(PPP1R12A)
CDK: 105084895(PPP1R12A)
BACU: 103020020(PPP1R12A)
LVE: 103071997(PPP1R12A)
OOR: 101279306(PPP1R12A)
DLE: 111167253(PPP1R12A)
PCAD: 102992707(PPP1R12A)
PSIU: 116760401(PPP1R12A)
ECB: 100060501(PPP1R12A)
EPZ: 103549928(PPP1R12A)
EAI: 106831522(PPP1R12A)
MYB: 102251394(PPP1R12A)
MYD: 102765262(PPP1R12A)
MMYO: 118650077(PPP1R12A)
MLF: 102429955(PPP1R12A)
MNA: 107526828(PPP1R12A)
PKL: 118730887(PPP1R12A)
HAI: 109375211(PPP1R12A)
DRO: 112322163(PPP1R12A)
SHON: 118984712(PPP1R12A)
AJM: 119058981(PPP1R12A)
PDIC: 114513386(PPP1R12A)
PHAS: 123822821(PPP1R12A)
MMF: 118623369(PPP1R12A)
RFQ: 117028313(PPP1R12A)
PALE: 102898474(PPP1R12A)
PGIG: 120583373(PPP1R12A)
PVP: 105301889(PPP1R12A)
RAY: 107503696(PPP1R12A)
MJV: 108408094(PPP1R12A)
TOD: 119247473(PPP1R12A)
SARA: 101556321(PPP1R12A)
LAV: 100673922(PPP1R12A)
TMU: 101341352
DNM: 101447857(PPP1R12A)
MDO: 100019488(PPP1R12A)
GAS: 123250694(PPP1R12A)
SHR: 100926931(PPP1R12A)
PCW: 110213174(PPP1R12A)
OAA: 100077235(PPP1R12A)
GGA: 396020(PPP1R12A)
PCOC: 116226728(PPP1R12A)
MGP: 100539276(PPP1R12A)
CJO: 107311018(PPP1R12A)
NMEL: 110392872(PPP1R12A)
APLA: 101800288(PPP1R12A)
ACYG: 106046454(PPP1R12A)
AFUL: 116497380(PPP1R12A)
TGU: 100220857(PPP1R12A)
LSR: 110469380(PPP1R12A)
SCAN: 103813426(PPP1R12A)
PMOA: 120499763(PPP1R12A)
OTC: 121338585(PPP1R12A)
PRUF: 121352505(PPP1R12A)
GFR: 102037308(PPP1R12A)
FAB: 101822232(PPP1R12A)
PHI: 102107346(PPP1R12A)
PMAJ: 107204392(PPP1R12A)
CCAE: 111933170(PPP1R12A)
CCW: 104698411(PPP1R12A)
ETL: 114063665(PPP1R12A)
ZAB: 102071992(PPP1R12A)
FPG: 101914871(PPP1R12A)
FCH: 102052384(PPP1R12A)
CLV: 102098984(PPP1R12A)
EGZ: 104132935(PPP1R12A)
NNI: 104010975(PPP1R12A)
ACUN: 113488441(PPP1R12A)
TALA: 104368605(PPP1R12A)
PADL: 103919928(PPP1R12A)
ACHC: 115336095(PPP1R12A)
AAM: 106488611(PPP1R12A)
AROW: 112963277(PPP1R12A)
NPD: 112956239(PPP1R12A)
DNE: 112983349(PPP1R12A)
ASN: 102381466(PPP1R12A)
AMJ: 102562278(PPP1R12A)
CPOO: 109315966(PPP1R12A)
GGN: 109295752(PPP1R12A)
PSS: 102460329(PPP1R12A)
CMY: 102930708(PPP1R12A)
CPIC: 101949705(PPP1R12A)
TST: 117878110(PPP1R12A)
CABI: 116835801(PPP1R12A)
MRV: 120380171(PPP1R12A)
ACS: 100560455(ppp1r12a)
PVT: 110084990(PPP1R12A)
SUND: 121930949(PPP1R12A)
PBI: 103053749(PPP1R12A)
PMUR: 107284036(PPP1R12A)
TSR: 106547769(PPP1R12A)
PGUT: 117655359(PPP1R12A)
VKO: 123036395(PPP1R12A)
ZVI: 118091493(PPP1R12A)
GJA: 107113829(PPP1R12A)
XLA: 108711109(ppp1r12a.L) 108713841 108715193 733200(ppp1r12a.S)
XTR: 100487727 100493563(ppp1r12a)
NPR: 108799788(PPP1R12A)
RTEM: 120917244 120931940(PPP1R12A)
BBUF: 120980976(PPP1R12A) 120981057
BGAR: 122920592 122927987(PPP1R12A)
DRE: 445393(ppp1r12a) 571837(zmp:0000001167)
SGH: 107560300(ppp1r12a) 107561184 107591124
CCAR: 109076480
IPU: 108279475(ppp1r12a)
SMEO: 124392160(zmp:0000001167)
AMEX: 103046804(ppp1r12a)
TRU: 101079088(ppp1r12a)
LCO: 104924035(ppp1r12a) 104928858
NCC: 104949170(ppp1r12a) 104956193
ELY: 117262461(zmp:0000001167)
PLEP: 121950090(zmp:0000001167)
SLUC: 116038311(zmp:0000001167)
GAT: 120808673(zmp:0000001167)
PPUG: 119195724(zmp:0000001167)
MSAM: 119893300(zmp:0000001167) 119918120(ppp1r12a)
CUD: 121515748(zmp:0000001167)
MZE: 101469187
ONL: 100691168 100701481(ppp1r12a)
OAU: 116325451(ppp1r12a) 116326292(zmp:0000001167)
XCO: 114160902(ppp1r12a)
PRET: 103459134(ppp1r12a)
KMR: 108233296(ppp1r12a)
AOCE: 111568454(ppp1r12a) 111577267
CSEM: 103380280 103382552(ppp1r12a)
POV: 109641125(ppp1r12a)
SSEN: 122776008(zmp:0000001167)
HHIP: 117763329(zmp:0000001167)
LCF: 108873647(ppp1r12a) 108886890
SDU: 111229837
SLAL: 111660032(ppp1r12a) 111666970
XGL: 120793526(zmp:0000001167) 120801257(ppp1r12a)
HCQ: 109507600 109530079(ppp1r12a)
BPEC: 110161521(ppp1r12a) 110169303
MALB: 109967812(ppp1r12a) 109972924
SASA: 106584787
OTW: 112219159(zmp:0000001167) 112238870
OGO: 124037460(zmp:0000001167) 124038538
ELS: 105018059
AANG: 118218693
BFO: 118407388
BBEL: 109463543
CIN: 100187107
SCLV: 120330795
DGR: 6556574
ACOZ: 120952109
AARA: 120896407
AAG: 5576767
AALB: 109416470
CPII: 120424884
CNS: 116338909
AME: 726541
ACER: 108002538
ALAB: 122712797
BIM: 100749351
BBIF: 117204474
BVK: 117235158
BVAN: 117153585
BTER: 100646538
BPYO: 122569581
CCAL: 108628490
OBB: 114871136
MGEN: 117228672
NMEA: 116425033
CGIG: 122395116
SOC: 105198893
MPHA: 105827753
AEC: 105145669
ACEP: 105617107
PBAR: 105426810
VEM: 105565091
HST: 105192635
DQU: 106741992
CFO: 105251152
FEX: 115239072
LHU: 105677120
PGC: 109854374
PCF: 106791741
PFUC: 122524385
VPS: 122634018
NVI: 100114433
TPRE: 106648966
MDL: 103580139
CGLO: 123260605
FAS: 105270029
DAM: 107035755
AGIF: 122848681
CCIN: 107269253
TCA: 659634
SOY: 115890036
CSET: 123322743
OTU: 111427104
HHAL: 106689635
NLU: 111050492
ZNE: 110827706
CSEC: 111868082
PJA: 122249215
HAME: 121874079
PCLA: 123755300
PTRU: 123510981
HAZT: 108664356
EAF: 111700938
DSV: 119463364
RSAN: 119401456
RMP: 119164099
VDE: 111255382
VJA: 111261193
CEL: CELE_C06C3.1(mel-11)
CBR: CBG_00870(Cbr-mel-11)
BGT: 106067201
GAE: 121370381
HRF: 124110875
HRJ: 124263368
CRG: 105330003
PMAX: 117327866
OSN: 115229173
NVE: 5515674
ATEN: 116303719
XEN: 124439617
HMG: 100214665
 » show all
Reference
PMID:7982954
  Authors
Shimizu H, Ito M, Miyahara M, Ichikawa K, Okubo S, Konishi T, Naka M, Tanaka T, Hirano K, Hartshorne DJ, et al.
  Title
Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.
  Journal
J Biol Chem 269:30407-11 (1994)
  Sequence
[gga:396020]
Reference
  Authors
Grassie ME, Moffat LD, Walsh MP, MacDonald JA
  Title
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.
  Journal
Arch Biochem Biophys 510:147-59 (2011)
DOI:10.1016/j.abb.2011.01.018
LinkDB

KEGG   ORTHOLOGY: K12329
Entry
K12329                      KO                                     
Symbol
PPP1R12B, MYPT2
Name
protein phosphatase 1 regulatory subunit 12B
Pathway
map04270  Vascular smooth muscle contraction
map04510  Focal adhesion
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
Genes
HSA: 4660(PPP1R12B)
PTR: 457629(PPP1R12B)
PPS: 100970244(PPP1R12B)
PON: 103890237(PPP1R12B)
NLE: 100592313(PPP1R12B)
MCC: 705775(PPP1R12B)
MCF: 102121021(PPP1R12B)
CSAB: 103230309(PPP1R12B)
CATY: 105575564(PPP1R12B)
PANU: 101008443(PPP1R12B)
TGE: 112624136(PPP1R12B)
RRO: 104674509(PPP1R12B)
RBB: 108545061(PPP1R12B)
TFN: 117075738(PPP1R12B)
PTEH: 111522682(PPP1R12B)
CJC: 100404247(PPP1R12B)
SBQ: 101053159(PPP1R12B)
CSYR: 103275384
MMUR: 105860003(PPP1R12B)
MMU: 329251(Ppp1r12b)
MCAL: 110293509(Ppp1r12b)
MPAH: 110322008(Ppp1r12b)
RNO: 304813(Ppp1r12b)
MCOC: 116099596(Ppp1r12b)
MUN: 110546742
CGE: 100753601(Ppp1r12b)
PLEU: 114698113(Ppp1r12b)
NGI: 103731836(Ppp1r12b)
HGL: 101711489(Ppp1r12b)
CPOC: 100729743(Ppp1r12b)
CCAN: 109690053(Ppp1r12b)
DORD: 105986532(Ppp1r12b)
DSP: 122109161(Ppp1r12b)
OCU: 100356902(PPP1R12B)
OPI: 101523577(PPP1R12B)
TUP: 102500634(PPP1R12B)
CFA: 490230(PPP1R12B)
VVP: 112934572(PPP1R12B)
VLG: 121493360(PPP1R12B)
AML: 100470069(PPP1R12B)
UAH: 113242537(PPP1R12B)
UAR: 123785739(PPP1R12B)
ELK: 111151011
MPUF: 101674914(PPP1R12B)
ORO: 101369772(PPP1R12B)
EJU: 114221938(PPP1R12B)
ZCA: 113931863(PPP1R12B)
MLX: 118014193(PPP1R12B)
FCA: 101098766(PPP1R12B)
PYU: 121021683(PPP1R12B)
PBG: 122475957(PPP1R12B)
PTG: 102950482(PPP1R12B)
PPAD: 109256388(PPP1R12B)
AJU: 106973120(PPP1R12B)
HHV: 120228862(PPP1R12B)
BTA: 107131237(PPP1R12B)
BOM: 102286584(PPP1R12B)
BBUB: 102409062(PPP1R12B)
CHX: 102181773(PPP1R12B)
OAS: 101114596(PPP1R12B)
ODA: 120880088(PPP1R12B)
CCAD: 122452339(PPP1R12B)
SSC: 100525832(PPP1R12B)
CBAI: 105069988(PPP1R12B)
BACU: 103012518(PPP1R12B)
LVE: 103071840(PPP1R12B)
OOR: 101289221(PPP1R12B)
DLE: 111168304(PPP1R12B)
PCAD: 102980129(PPP1R12B)
PSIU: 116764804(PPP1R12B)
ECB: 100063928(PPP1R12B)
EPZ: 103561986(PPP1R12B)
EAI: 106840263(PPP1R12B)
MYB: 102263913(PPP1R12B)
MYD: 102762227(PPP1R12B)
MMYO: 118678779(PPP1R12B)
MLF: 102419496
MNA: 107536013(PPP1R12B)
PKL: 118710507
HAI: 109380462(PPP1R12B)
DRO: 112318742(PPP1R12B)
SHON: 119003932(PPP1R12B)
PDIC: 114512267(PPP1R12B)
PHAS: 123805100(PPP1R12B)
MMF: 118640525(PPP1R12B)
RFQ: 117018401(PPP1R12B)
PALE: 102879733(PPP1R12B)
PGIG: 120619279(PPP1R12B)
PVP: 105296949
RAY: 107502991(PPP1R12B)
MJV: 108385698
TOD: 119233942(PPP1R12B)
SARA: 101547060
LAV: 100675940(PPP1R12B)
DNM: 101441649(PPP1R12B)
MDO: 100011797(PPP1R12B)
GAS: 123247236(PPP1R12B)
SHR: 100925265(PPP1R12B)
PCW: 110219617(PPP1R12B)
OAA: 100077407(PPP1R12B)
GGA: 395478(PPP1R12B)
PCOC: 116238747(PPP1R12B)
MGP: 100545452 104914452(PPP1R12B)
CJO: 107324641(PPP1R12B)
NMEL: 110388357(PPP1R12B)
APLA: 101797997(PPP1R12B)
ACYG: 106045864(PPP1R12B)
AFUL: 116498840(PPP1R12B)
TGU: 100224964(PPP1R12B)
LSR: 110469162(PPP1R12B) 110469188
SCAN: 103822442(PPP1R12B)
PMOA: 120497304(PPP1R12B)
OTC: 121345537(PPP1R12B)
PRUF: 121365385(PPP1R12B)
GFR: 102044251
FAB: 101818016
PHI: 102113018(PPP1R12B)
PMAJ: 107214882(PPP1R12B)
CCAE: 111939610(PPP1R12B)
CCW: 104692457(PPP1R12B)
ETL: 114064784(PPP1R12B)
ZAB: 102066150(PPP1R12B)
FPG: 101915795(PPP1R12B)
FCH: 102059378(PPP1R12B)
NNI: 104011079
ACUN: 113488963(PPP1R12B)
TALA: 104365770(PPP1R12B)
PADL: 103913809(PPP1R12B)
ACHC: 115334870(PPP1R12B)
AAM: 106500257(PPP1R12B)
AROW: 112965075(PPP1R12B)
NPD: 112959166(PPP1R12B)
DNE: 112983848(PPP1R12B)
ASN: 102387200(PPP1R12B)
AMJ: 102561475(PPP1R12B)
CPOO: 109317606(PPP1R12B)
GGN: 109295148(PPP1R12B)
PSS: 102450232(PPP1R12B)
CMY: 102943827(PPP1R12B)
CPIC: 101931457(PPP1R12B)
TST: 117875973(PPP1R12B)
CABI: 116831705(PPP1R12B)
MRV: 120403388(PPP1R12B)
ACS: 100566099(ppp1r12b)
PVT: 110073397(PPP1R12B)
SUND: 121927708(PPP1R12B)
PBI: 103051701(PPP1R12B)
PMUR: 107284458(PPP1R12B)
PGUT: 117663765(PPP1R12B)
VKO: 123032013
PMUA: 114599419(PPP1R12B)
ZVI: 118088813(PPP1R12B)
XLA: 108708153(ppp1r12b.L)
XTR: 780217(ppp1r12b)
DRE: 101885790
SRX: 107746501
SANH: 107697018
SGH: 107601321
CCAR: 109081823
AMEX: 103026736
EEE: 113588809(ppp1r12b)
LCO: 104927444
ELY: 117258417
PLEP: 121946950
SLUC: 116062047
GAT: 120829572
PPUG: 119222028
CUD: 121517858
MZE: 101471341
ONL: 100701156
OAU: 116310937
OLA: 101165234
OML: 112158651
XMA: 102217927
XCO: 114139678
XHE: 116729953
PRET: 103467653
PFOR: 103144026
PLAI: 106934828
PMEI: 106918288
CVG: 107083900
CTUL: 119782050
NFU: 107391259
KMR: 108232022
ALIM: 106519285
AOCE: 111572093
CSEM: 103385321
POV: 109635001
LCF: 108882116
SDU: 111224778(ppp1r12a) 111238191
SLAL: 111654989
XGL: 120803962
HCQ: 109514994
BPEC: 110164829
MALB: 109966768
SASA: 106572423
SALP: 111966596
ELS: 105013718
SFM: 114909186
PKI: 111855304
AANG: 118207782
LOC: 102686196
ARUT: 117427585
CMK: 103179091
RTP: 109927189(ppp1r12b)
DCI: 103514142
DFR: 124494180
 » show all
Reference
PMID:9570949
  Authors
Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M
  Title
A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping.
  Journal
Genomics 49:59-68 (1998)
DOI:10.1006/geno.1998.5222
  Sequence
[hsa:4660]
Reference
  Authors
Grassie ME, Moffat LD, Walsh MP, MacDonald JA
  Title
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.
  Journal
Arch Biochem Biophys 510:147-59 (2011)
DOI:10.1016/j.abb.2011.01.018
LinkDB

KEGG   ORTHOLOGY: K17457
Entry
K17457                      KO                                     
Symbol
PPP1R12C, MBS85
Name
protein phosphatase 1 regulatory subunit 12C
Pathway
map04270  Vascular smooth muscle contraction
map04510  Focal adhesion
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
Genes
HSA: 54776(PPP1R12C)
PTR: 456295(PPP1R12C)
PPS: 100967966(PPP1R12C)
GGO: 101136268(PPP1R12C) 115933218
PON: 100444334(PPP1R12C)
NLE: 100596166(PPP1R12C)
MCC: 114674157(PPP1R12C) 698538
MCF: 102119955(PPP1R12C)
CSAB: 103235290(PPP1R12C)
CATY: 105582740(PPP1R12C)
PANU: 101014051(PPP1R12C)
TGE: 112613329(PPP1R12C)
RRO: 104674755(PPP1R12C)
RBB: 108542522(PPP1R12C)
TFN: 117091723(PPP1R12C)
PTEH: 111521200(PPP1R12C)
CJC: 100407435(PPP1R12C)
SBQ: 101046107(PPP1R12C)
CSYR: 103267507(PPP1R12C)
MMUR: 105877190(PPP1R12C)
OGA: 100963170(PPP1R12C)
MMU: 232807(Ppp1r12c)
MCAL: 110297840(Ppp1r12c)
MPAH: 110336360(Ppp1r12c)
RNO: 499076(Ppp1r12c)
MCOC: 116101543(Ppp1r12c)
MUN: 110561072(Ppp1r12c)
CGE: 100765970(Ppp1r12c)
PLEU: 114689078(Ppp1r12c)
NGI: 103744825(Ppp1r12c)
HGL: 101714373(Ppp1r12c)
CPOC: 100714649(Ppp1r12c)
CCAN: 109696269(Ppp1r12c)
DORD: 105999544(Ppp1r12c)
DSP: 122110725(Ppp1r12c)
OCU: 103347470(PPP1R12C)
OPI: 101533680(PPP1R12C)
TUP: 102475906(PPP1R12C)
CFA: 100683226(PPP1R12C)
VVP: 112909382(PPP1R12C)
VLG: 121485042(PPP1R12C)
AML: 100476917(PPP1R12C)
UMR: 103680310(PPP1R12C)
UAH: 113247365(PPP1R12C)
UAR: 123786950(PPP1R12C)
ELK: 111140038
MPUF: 101691499(PPP1R12C)
ORO: 101384064(PPP1R12C)
EJU: 114202068(PPP1R12C)
ZCA: 113935792(PPP1R12C)
MLX: 117997778(PPP1R12C)
FCA: 101092809(PPP1R12C)
PYU: 121023384(PPP1R12C)
PBG: 122493745(PPP1R12C)
PTG: 102964615(PPP1R12C)
PPAD: 109259902(PPP1R12C)
AJU: 106980875(PPP1R12C)
HHV: 120239719(PPP1R12C)
BTA: 512431(PPP1R12C)
BOM: 102273254(PPP1R12C)
BIU: 109571856(PPP1R12C)
BBUB: 102403593(PPP1R12C)
CHX: 102187707(PPP1R12C)
OAS: 101122546(PPP1R12C)
ODA: 120873035(PPP1R12C)
CCAD: 122420802(PPP1R12C)
SSC: 100626700(PPP1R12C)
CFR: 102511905(PPP1R12C)
CBAI: 105074352(PPP1R12C)
CDK: 105098775(PPP1R12C)
BACU: 103010788(PPP1R12C)
LVE: 103085204(PPP1R12C)
OOR: 101277066(PPP1R12C)
DLE: 111180975(PPP1R12C)
PCAD: 102987074(PPP1R12C)
PSIU: 116743754(PPP1R12C)
EPZ: 103562875(PPP1R12C)
EAI: 106840918(PPP1R12C)
MYB: 102245599(PPP1R12C)
MYD: 102759047(PPP1R12C) 102760558
MMYO: 118655200(PPP1R12C)
MLF: 102421040(PPP1R12C)
MNA: 107541310(PPP1R12C)
PKL: 118715912(PPP1R12C)
HAI: 109373751(PPP1R12C)
DRO: 112314020(PPP1R12C)
SHON: 118981343(PPP1R12C)
AJM: 119059962(PPP1R12C)
PDIC: 114511524(PPP1R12C)
PHAS: 123813340(PPP1R12C)
MMF: 118639397(PPP1R12C)
RFQ: 117034835(PPP1R12C)
PALE: 102878573(PPP1R12C)
PGIG: 120598380(PPP1R12C)
PVP: 105304953(PPP1R12C)
RAY: 107515441(PPP1R12C)
MJV: 108396329(PPP1R12C)
TOD: 119249751(PPP1R12C)
SARA: 101539889(PPP1R12C)
LAV: 100669550(PPP1R12C)
TMU: 101355540
DNM: 101421478(PPP1R12C)
GAS: 123256107(PPP1R12C)
SHR: 116422717(PPP1R12C)
PCW: 110219818(PPP1R12C)
OAA: 100087416(PPP1R12C)
GGA: 107049646(PPP1R12C)
PCOC: 116239627(PPP1R12C)
CJO: 107307229(PPP1R12C)
NMEL: 110391351(PPP1R12C)
ASN: 102380217(PPP1R12C)
AMJ: 102559388(PPP1R12C)
CMY: 102934075(PPP1R12C)
CPIC: 101937529
TST: 117888780(PPP1R12C)
CABI: 116834895(PPP1R12C)
MRV: 120388252(PPP1R12C)
ACS: 100561659(ppp1r12c)
PVT: 110078487(PPP1R12C)
SUND: 121933309(PPP1R12C)
PBI: 103051816(PPP1R12C)
PMUR: 107282540(PPP1R12C) 107299194
TSR: 106548413(PPP1R12C)
PGUT: 117669078(PPP1R12C)
VKO: 123032162(PPP1R12C)
PMUA: 114608033(PPP1R12C)
ZVI: 118094322(PPP1R12C)
GJA: 107125719(PPP1R12C)
XTR: 734022(ppp1r12c)
RTEM: 120915347(PPP1R12C)
BBUF: 121001445(PPP1R12C)
BGAR: 122928652(PPP1R12C)
DRE: 570218(ppp1r12c)
SANH: 107688807 107694908(ppp1r12c)
CCAR: 109080602
IPU: 108273132(ppp1r12c)
PHYP: 113538332(ppp1r12c)
SMEO: 124400078(ppp1r12c)
AMEX: 103031099
EEE: 113590831
TRU: 101061089(ppp1r12c)
LCO: 104920398(ppp1r12c)
NCC: 104956269(ppp1r12c)
ELY: 117255537(ppp1r12c)
PLEP: 121942236(ppp1r12c)
SLUC: 116039650(ppp1r12c)
ECRA: 117948723(zmp:0000001167) 117959899(ppp1r12c)
PFLV: 114559811 114571436(ppp1r12c)
GAT: 120825687(ppp1r12c)
PPUG: 119217679(ppp1r12c)
MSAM: 119899751(ppp1r12c)
CUD: 121508793(ppp1r12c)
MZE: 101469213(ppp1r12c)
ONL: 109194150(ppp1r12c)
OAU: 116331485(ppp1r12c)
OML: 112152858(zmp:0000001167) 112157049(ppp1r12c)
XMA: 102219491
XCO: 114144272
PRET: 103463409
GAF: 122829052(ppp1r12c) 122835467(zmp:0000001167)
CVG: 107085515(ppp1r12c)
CTUL: 119779348(ppp1r12c) 119787421(zmp:0000001167)
NFU: 107396436
KMR: 108251359(ppp1r12c)
ALIM: 106526908(ppp1r12c)
NWH: 119416463(zmp:0000001167) 119422710(ppp1r12c)
AOCE: 111575061(ppp1r12c)
CSEM: 103384367
POV: 109627557(ppp1r12c)
SSEN: 122770728(ppp1r12c)
HHIP: 117759979(ppp1r12c)
LCF: 108884541(ppp1r12c)
SDU: 111217994
SLAL: 111660421
XGL: 120800716(ppp1r12c)
HCQ: 109521847
BPEC: 110173828(ppp1r12c)
MALB: 109956791(ppp1r12c)
SASA: 100194922(pp12c) 106564933
ELS: 105021605
SFM: 108918682
PKI: 111850734
AANG: 118215440(zmp:0000001167)
PSPA: 121305868(ppp1r12c)
LCM: 102356480(PPP1R12C)
AGB: 108915290
FOC: 113206271
SDM: 118195112
XEN: 124444043
 » show all
Reference
  Authors
Tan I, Ng CH, Lim L, Leung T
  Title
Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
  Journal
J Biol Chem 276:21209-16 (2001)
DOI:10.1074/jbc.M102615200
  Sequence
[hsa:54776]
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