KEGG ORTHOLOGY: K07360

KEGG

ORTHOLOGY: K07360

Entry

K07360                      KO

Symbol

ZAP70

Name

tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]

Pathway

Ras signaling pathway

NF-kappa B signaling pathway

Natural killer cell mediated cytotoxicity

Th1 and Th2 cell differentiation

Th17 cell differentiation

T cell receptor signaling pathway

Yersinia infection

PD-L1 expression and PD-1 checkpoint pathway in cancer

Primary immunodeficiency

Disease

Combined immunodeficiency

Infantile-onset multisystem autoimmune disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04064 NF-kappa B signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04660 T cell receptor signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04658 Th1 and Th2 cell differentiation
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04659 Th17 cell differentiation
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
  09163 Immune disease
   05340 Primary immunodeficiency
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K07360  ZAP70; tyrosine-protein kinase ZAP-70
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SYK family
   K07360  ZAP70; tyrosine-protein kinase ZAP-70

Other DBs

GO:

Genes

HSA:	7535(ZAP70)

PTR:	459427(ZAP70)

PPS:

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:

MTHB:

MNI:

CSAB:

103241092(ZAP70)

CATY:

105583698(ZAP70)

PANU:

101008565 116270368

TGE:

MLEU:

105531655(ZAP70)

RRO:

RBB:

TFN:

PTEH:

CANG:

105522125(ZAP70)

CJC:

SBQ:	101036932(ZAP70)

CIMI:

ANAN:

105706424 135273059 135273177

CSYR:

MMUR:

LCAT:

PCOQ:

105808257(ZAP70)

OGA:

MMU:	22637(Zap70)

MCAL:

MPAH:

RNO:	301348(Zap70)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103738088(Zap70)

HGL:	101716577(Zap70)

CPOC:

CCAN:

DORD:

105988287(Zap70)

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:	102469719(ZAP70)

GVR:	103582470 103610308

CFA:	100271860(ZAP70)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

101682004(ZAP70)

MNP:

MLK:

NVS:

ORO:	101377393(ZAP70)

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101097059(ZAP70)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:	102969244(ZAP70)

PPAD:

PUC:

AJU:

HHV:

BTA:	504509(ZAP70)

BOM:	102287403(ZAP70)

BIU:

BBUB:

BBIS:

104980820(ZAP70)

CHX:

OAS:

BTAX:

CSUM:

138077523(ZAP70)

ODA:

CCAD:

MREE:

136163031(ZAP70)

MBEZ:

SSC:

CFR:

CBAI:

105072189(ZAP70)

CDK:

VPC:

BACU:

103014268(ZAP70)

BMUS:

LVE:	103074297(ZAP70)

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100147296(ZAP70)

EPZ:	103561441(ZAP70)

EAI:

MYB:	102259670(ZAP70)

MYD:	102775001(ZAP70)

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

101542134(ZAP70)

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100025187(ZAP70)

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138175743(ZAP70)

GGA:	420086(ZAP70)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106048412(ZAP70)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:	102034810(ZAP70)

FAB:	101809285(ZAP70)

OMA:

PHI:	102108601(ZAP70)

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138099651(ZAP70)

ETL:

ZAB:

ZLE:

ACHL:

103808683(ZAP70)

SVG:

MMEA:

HRT:

SATI:

136371931(ZAP70)

FPG:	101916784(ZAP70)

FCH:

CCRI:

104166677(ZAP70)

NNT:	104405591(ZAP70)

SHAB:

ACUN:

TALA:

ACHC:

HALD:

104318887(ZAP70)

HLE:	104828554(ZAP70)

AGEN:

HHAR:

GCL:

CSTI:

104551177(ZAP70)

LDI:	104350202(ZAP70)

MNB:	103769728(ZAP70)

DPUB:

104309483(ZAP70)

PPUS:

AVIT:

BRHI:

104497430(ZAP70)

EGZ:	104132036(ZAP70)

NNI:	104018770(ZAP70)

PCRI:

104037735(ZAP70)

PCAO:

104043221(ZAP70)

PADL:

103921148(ZAP70)

AFOR:

FGA:	104080535(ZAP70)

GSTE:

104262554(ZAP70)

CLV:

MUI:	104539949(ZAP70)

PGUU:

104465787(ZAP70)

PLET:

104619578(ZAP70)

EHS:	104514526(ZAP70)

CMAC:

104483940(ZAP70)

CUCA:

TEO:	104371008(ZAP70)

BREG:

104641115(ZAP70)

OHA:	104335639(ZAP70)

ACAR:

CPEA:

104392900(ZAP70)

CVF:	104290087(ZAP70)

RTD:

AAM:	106486099(ZAP70)

AROW:

NPD:

TGT:	104568052(ZAP70)

DNE:

SCAM:

104139149(ZAP70)

ASN:

AMJ:

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:	106542969(ZAP70)

PGUT:

APRI:

PTEX:

NSS:

VKO:	123021393 123021463

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108706868(zap70.S) 446840(zap70.L)

XTR:	448557(zap70)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	553615(zap70)

SRX:	107731183 107745809

SANH:

107676994 107695253

SGH:	107548917 107585931

CCAR:

109060641 109071103

CAUA:

113069918 113107244

CGIB:

127963912 128018756

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137026995(zap70)

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00019257G001

LCO:

NCC:	104944350(zap70)

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137793555(zap70)

CVE:	137870375(zap70)

MSAM:

SCHU:

CUD:

ALAT:

ASTR:

137598866(zap70)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

103137269 103137273

PLAI:

106942241 106942586

PMEI:

106909663 106925948

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

106516821(zap70)

NWH:

AOCE:

EJA:	138200497(zap70)

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125968921(zap70)

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

106584369 106613845

STRU:

115158333 115192548

OTW:	112242249 112250942

OMY:	110521509 110524376

OGO:	123997009 124037725

ONE:	115108383 115144959

OKI:	109897908 109902571

OKE:	118359179 118390472

SALP:

111971408 111975278

SNH:	120051818 120054481

CCLU:

121533456 121539899

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

121300629 121301391

ARUT:

117401315 117966356

PSEX:

LCM:	102357488(ZAP70)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116944195 116945852

LRJ:

BBEL:

SCLV:

LPIC:

OFU:

TCF:

VDE:

VJA:

UDV:

SDM:

OED:

MMER:

DGT:

XEN:	124443747 124445826

HSY:	130635496 130635613

Reference

Authors

Kuroyama H, Ikeda T, Kasai M, Yamasaki S, Tatsumi M, Utsuyama M, Saito T, Hirokawa K

Title

Identification of a novel isoform of ZAP-70, truncated ZAP kinase.

Journal

Biochem Biophys Res Commun 315:935-41 (2004)
DOI:10.1016/j.bbrc.2004.01.127

Sequence

[hsa:7535]

LinkDB

DBGET integrated database retrieval system