KEGG ORTHOLOGY: K07422

ORTHOLOGY: K07422

Entry

K07422                      KO

Symbol

CYP2U1

Name

long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]

Pathway

map00071

Fatty acid degradation

map00590

Arachidonic acid metabolism

map01100

Metabolic pathways

Reaction

R01348

fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)

R07041

arachidonic acid:oxygen 1-oxidoreductase

R07046

Disease

H00266

Hereditary spastic paraplegia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07422  CYP2U1; long-chain fatty acid omega-monooxygenase
   00590 Arachidonic acid metabolism
    K07422  CYP2U1; long-chain fatty acid omega-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07422  CYP2U1; long-chain fatty acid omega-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.80  long-chain fatty acid omega-monooxygenase
     K07422  CYP2U1; long-chain fatty acid omega-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K07422  CYP2U1; long-chain fatty acid omega-monooxygenase

Other DBs

GO:

0052869

Genes

HSA:	113612(CYP2U1)

PTR:	471267(CYP2U1)

PPS:	100993565(CYP2U1)

GGO:

101138067

PON:	100172128(CYP2U1)

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:	102136088(CYP2U1)

MTHB:

MNI:

CSAB:

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:

SBQ:

CIMI:

108289513(CYP2U1)

ANAN:

105706268(CYP2U1)

CSYR:

103258322

MMUR:

105872331

LCAT:

123627734

ERUF:

138375456(CYP2U1)

PCOQ:

105818955

OGA:

100957765

MMU:	71519(Cyp2u1)

MCAL:

110291616

MPAH:

110320955

RNO:	310848(Cyp2u1)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102905412(Cyp2u1)

MORG:

MFOT:

AAMP:

CNL:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138826975(Cyp2u1)

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

OCZ:

TUP:

GVR:

CFA:	100685915(CYP2U1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101089856(CYP2U1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	535227(CYP2U1)

BOM:	102268257(CYP2U1)

BIU:

BBUB:

BKE:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138082147(CYP2U1)

ODA:

120861743

CCAD:

122422254

MREE:

136147999(CYP2U1)

OVR:	110142663(CYP2U1)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115857235(CYP2U1)

DDP:	132426096(CYP2U1)

DLE:

111171487

PCAD:

102996045

PSIU:

116754398

PPHC:

136123857(CYP2U1)

NASI:

112397673

ECB:	100072967(CYP2U1)

EPZ:	103557036(CYP2U1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139022385(CYP2U1)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138166393(CYP2U1)

MLAO:

141519118(CYP2U1)

OAA:

100088100

TACU:

119935614

GGA:	422528(CYP2U1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137856487(CYP2U1)

ACYG:

106038668(CYP2U1)

CATA:

118247289

AFUL:

116488499

TGU:

100229295

LSR:	110468021(CYP2U1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139592225(CYP2U1)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138109613(CYP2U1)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136360516(CYP2U1)

CFAI:

136291307(CYP2U1)

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

SURA:

141942844(CYP2U1)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

142033010(CYP2U1)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

BRHI:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

CBOR:

142082082(CYP2U1)

GSTE:

104252092

CBOY:

140652287(CYP2U1)

MAME:

142409332(CYP2U1)

CLV:

CNIC:

MUI:

PGUU:

PLET:

CMAC:

CUCA:

TEO:

BREG:

GAME:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

LMIC:

141744100(CYP2U1)

NARQ:

141464639(CYP2U1)

AROW:

NPD:

TGT:

DNE:

SCAM:

AMJ:	102561654(CYP2U1)

CPOO:

109309402

GGN:

109301060

PSS:

102457687

CIZ:	142012732(CYP2U1)

CMY:

102945537

CCAY:

125635589

LKP:	140910293(CYP2U1)

NDS:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139320405(CYP2U1)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:	128327861 128327928

GJA:

107123074

STOW:

125440187

EMC:

129336644

XLA:	108710146(cyp2u1.L)

XTR:	100127656(cyp2u1)

NPR:

108785422

RTEM:

120917975

ACAT:

141110623(CYP2U1)

PADS:

140326783(CYP2U1)

BBUF:

120989932

BGAR:

122943901

DTC:	141086177(CYP2U1)

MUO:	115461166 115461167 115461169 115461170

GSH:

117365686

DRE:	556280(cyp2u1)

SRX:	107729355 107756983

SANH:

107683164

SGH:	107583182 107594430

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141337055(cyp2u1)

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137032038(cyp2u1)

MASI:

127445400

TROS:

130552706

TDW:

130412596

MANU:

129444128(cyp2u1)

PDAB:

135785804(cyp2u1)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:

TFS:

TNG:	GSTEN00033453G001

LCO:	104927270 109137375

NCC:

104953567

TBEN:

117481692

CGOB:

115009982

PGEO:

117449455(cyp2u1)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137792851(cyp2u1)

CVE:	137884888(cyp2u1)

MSAM:

119898920 119898921

SCHU:

122872867

EARM:

139296276(cyp2u1)

CUD:

121507949

SPUL:

138595110(cyp2u1)

LMIX:

132990148

HTC:	141799870(cyp2u1)

ALAT:

119020705

ASTR:

137600506(cyp2u1)

PKLU:

139225632(cyp2u1)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:	138209558(cyp2u1)

BFRE:

138615609(cyp2u1)

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125968424(cyp2u1)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140377364(cyp2u1)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137179844(cyp2u1)

GMH:

SASA:

STRU:

OTW:

OMY:	110497323 110497324

OGO:

124002282

ONE:

115126484

OKI:	109876658 109877655

OKE:

118373435

OMM:

135507065

OCLA:

139419065 139419071 139419105

SNH:	120034968 120034970

SFON:

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

140739156(cyp2u1)

PMRN:

116950746

LRJ:

133354259

BFO:	118406569 118408308 118413155 118413160 118415263 118418294 118422566

SCLV:

120336525 120347507

CLEP:

143444184 143444893 143446313 143448662 143450473 143451326 143451327 143451815 143452790 143452865 143468987 143471017 143471385

SPU:

575452

AJJ:	139960931 139965395 139984447

ARUN:

117290228 117290484 117291142 117296751 117298259 117298521 117299889 117301605 117305179 117305189 117305873 117306948 117307146 117307153 117307359

AFIL:

140135453 140136171 140136177 140136937 140137610 140137645 140138132 140138398 140138956 140139527 140139812 140139813 140140632 140140747 140140748 140140750 140141336 140141437 140141438 140141439 140142459 140142566 140142654 140142768 140143930 140146489 140147621 140148078 140149579 140151258 140152068 140152069 140152176 140152719 140152804 140155013 140156292 140156298 140156324 140156551 140156553 140156842 140156843 140156846 140157104 140157596 140157645 140157649 140158249 140158949 140158950 140158951 140159072 140159562 140160126 140160456 140160465 140160484 140160795 140161730 140161988 140162006 140162593 140162602 140163131 140163513 140164346 140164441 140165322 140165468 140165555 140165556 140165747 140166655 140166807 140167982 140168473 140170666 140171049 140171353 140172151 140172186 140172469 140172471 140172472 140172474 140172478

AJC:	117111688 117111833 117111834

PJA:

PCHN:

HAME:

PCLA:

ESN:

PORN:

PPOI:

DALB:

RSAN:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

129585224 129593997 129594991

LSAX:

138950930 138968590 138976804

BARL:

143277964 143278012 143278013 143278341 143280554 143280555 143288135 143297028 143297969 143301287

BGT:

106077375

GAE:

121374908

HRF:	124115847 124116310 124131950 124135569 124140770

HRJ:	124275489 124277344 124283921 124288838

HASI:

137256567 137286225 137290608 137291064

HCRA:

139452162 139452202 139473588 139479987 139480155

CRG:	105332607 105332627

CANU:

128167384

CVN:	111104462 111130517

OED:

125683403

PMAX:

117323517 117332983

MMER:

123532114 123536485 123537171 123547607 123556688 123556689 123558835

RPHI:

132713734 132726938 132741779 132754426

DPOL:

127858380 127863018 127869253 127869521 127871155 127872355 127874918

MAEA:

128207486 128231580

LJP:	135468176 135475525 135476481 135476636 135476712 135476718 135476976

LLON:

135482757 135486935 135494702 135495010 135496827 135502253 135502268 135502269 135503051

HSY:

130636270

» show all

Reference

PMID:14660610

Authors

Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.

Title

CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.

Journal

J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200

Sequence

[hsa:113612]

LinkDB

DBGET integrated database retrieval system