KEGG ORTHOLOGY: K07433

ORTHOLOGY: K07433

Entry

K07433                      KO

Symbol

CYP11B2

Name

steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04925

Aldosterone synthesis and secretion

Module

M00108

C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone

Reaction

R02218

progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02725

androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R02843

steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03262

corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)

R03263

R03329

steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R03851

11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)

R04850

17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating)

Disease

H00258

Aldosterone synthase deficiency

H00602

Glucocorticoid-remediable aldosteronism (GRA)

H01633

High blood pressure

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
    1.14.15.5  corticosterone 18-monooxygenase
     K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP11 family
   K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase

Other DBs

GO:	0004507 0047783

Genes

HSA:	1585(CYP11B2)

PTR:	745937(CYP11B2)

PPS:	100971238(CYP11B2)

GGO:

PON:

PPYG:

NLE:

SSYN:

MCC:	695914(CYP11B2)

MCF:	102137301(CYP11B2)

MTHB:

126961020 126961026

MNI:	105483796 105488428

CSAB:

103237547(CYP11B2)

CATY:

PANU:

MLEU:

RRO:

RBB:

TFN:

CANG:

CJC:	100415304(CYP11B2)

CIMI:

108291254(CYP11B2)

ANAN:

105728086(CYP11B2)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:	100948396 100958146

HGL:

101700701

CPOC:

100379213(Cyp11b2) 100727186

GVR:	103599088 103604864 103604866

» show all

Reference

PMID:2592361

Authors

Mornet E, Dupont J, Vitek A, White PC

Title

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

Journal

J Biol Chem 264:20961-7 (1989)

Sequence

[hsa:1585]

Reference

PMID:12452430

Authors

Bureik M, Lisurek M, Bernhardt R

Title

The human steroid hydroxylases CYP1B1 and CYP11B2.

Journal

Biol Chem 383:1537-51 (2002)
DOI:10.1515/BC.2002.174

LinkDB

ENZYME: 1.14.15.5

Entry

EC 1.14.15.5                Enzyme

Name

corticosterone 18-monooxygenase;
corticosterone 18-hydroxylase;
corticosterone methyl oxidase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

corticosterone,reduced-adrenodoxin:oxygen oxidoreductase (18-hydroxylating)

Reaction(IUBMB)

corticosterone + 2 reduced adrenodoxin + O2 + 2 H+ = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H2O [RN:R03262]

Reaction(KEGG)

R03262;
(other) R03263

Substrate

corticosterone [CPD:C02140];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

18-hydroxycorticosterone [CPD:C01124];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]

History

EC 1.14.15.5 created 1972

Pathway

ec00140

Steroid hormone biosynthesis

ec01100

Metabolic pathways

Orthology

K07433

steroid 11beta-monooxygenase / corticosterone 18-monooxygenase

Genes

HSA:	1585(CYP11B2)

PTR:	745937(CYP11B2)

PPS:	100971238(CYP11B2)

GGO:

101142418

PON:

100461139

PPYG:

129042640

NLE:

115830633

SSYN:

129486882

MCC:	695914(CYP11B2)

MCF:	102137301(CYP11B2)

MTHB:

126961020 126961026

MNI:	105483796 105488428

CSAB:

103237547(CYP11B2)

CATY:

105581294

PANU:

101002842

MLEU:

105536288

RRO:

104679775

RBB:

108536550

TFN:

117078861

CANG:

105509012

CJC:	100415304(CYP11B2)

CIMI:

108291254(CYP11B2)

ANAN:

105728086(CYP11B2)

CSYR:

103276450

MMUR:

105867373 105867374

LCAT:

123644516 123644520

PCOQ:

105813307 105813360

OGA:	100948396 100958146

HGL:

101700701

CPOC:

100379213(Cyp11b2) 100727186

GVR:	103599088 103604864 103604866

» show all

Reference

1 [PMID:4381410]

Authors

Raman PB, Sharma DC, Dorfman RI.

Title

Studies on aldosterone biosynthesis in vitro.

Journal

Biochemistry 5:1795-804 (1966)
DOI:10.1021/bi00870a004

Other DBs

ExplorEnz - The Enzyme Database:

1.14.15.5

IUBMB Enzyme Nomenclature:

1.14.15.5

ExPASy - ENZYME nomenclature database:

1.14.15.5

BRENDA, the Enzyme Database:

1.14.15.5

CAS:	37256-75-0

LinkDB

REACTION: R03262

Entry

R03262                      Reaction

Name

corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)

Definition

Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O

Equation

C02140 + 2 C00662 + C00007 + 2 C00080 <=> C01124 + 2 C00667 + C00001

Reaction class

RC00257

C01124_C02140

Enzyme

1.14.15.4 1.14.15.5

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Module

M00108

C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03262  Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O
    1.14.15.5
     R03262  Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O

Orthology

K07433

steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

Other DBs

RHEA:

11875

LinkDB

DBGET integrated database retrieval system