KEGG ORTHOLOGY: K07434

ORTHOLOGY: K07434

Entry

K07434                      KO

Symbol

CYP19A

Name

aromatase [EC:1.14.14.14]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

Module

M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

Reaction

R01840

androstenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)

R02351

19-oxoandrostenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)

R02501

testosterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)

R03087

19-oxotestosterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)

R04759

19-hydroxyandrostenedione,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase

R04761

19-hydroxytestosterone,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase

Disease

H00794

Aromatase excess syndrome

H02020

Aromatase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07434  CYP19A; aromatase
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07434  CYP19A; aromatase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07434  CYP19A; aromatase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14  aromatase
     K07434  CYP19A; aromatase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP19 family
   K07434  CYP19A; aromatase

Genes

HSA:	1588(CYP19A1)

PTR:	453433(CYP19A1)

PPS:	100984744(CYP19A1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	678697(CYP19A1)

MCF:	102117886(CYP19A1)

MTHB:

126959039

MNI:

105490390

CSAB:

103245629(CYP19A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100411557(CYP19A1)

SBQ:

101051393

CIMI:

108286664(CYP19A1)

ANAN:

105710056(CYP19A1)

CSYR:

103274056

MMUR:

105870707

LCAT:

123622663

ERUF:

138376016(CYP19A1)

PCOQ:

105821381

OGA:

100950881

MMU:	13075(Cyp19a1)

MCAL:

110301208

MPAH:

110328587

RNO:	25147(Cyp19a1)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102926053(Cyp19a1)

MORG:

MFOT:

AAMP:

CNL:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138809042(Cyp19a1)

PLOP:

NCAR:

MMMA:

ITI:

OCU:	100328545(CYP19A1)

OPI:

OCZ:

TUP:

GVR:

CFA:	494003(CYP19A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

MANO:

NSU:

LWW:

FCA:	101094932(CYP19A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

CCRU:

144231838(CYP19A1)

BTA:	281740(CYP19A1)

BOM:

102277416

BIU:

109565118

BBUB:

102392019

BKE:	129620598 129621471

BBIS:

104988240

CHX:	100861413(CYP19A1) 102172726

OAS:	100144423(CYP19)

BTAX:

128054322 128054328

CSUM:

138073095(CYP19A1)

ODA:	120852986 120853641

CCAD:

122443608

MREE:

136171828(CYP19A1) 136172629

OVR:	110122056(CYP19A1)

MBEZ:

129562964

SSC:	403331(CYP19A1) 403332(CYP19A2) 403333(CYP19A3)

CFR:	102519005 116664105

CBAI:

105067585

CDK:	105086637 105106135 116153434

VPC:

102526537

BACU:

103011787 103012080

BMUS:

118890681 118890682 118890683

LVE:	103080853 103081312

OOR:	101270659 101283540

LALB:

132531413 132531419

GMF:	132596756(CYP19A1) 132596757

DDP:	132419694(CYP19A1)

DLE:	111170860 111170861 111171015

PCAD:

102982383 102982657 102995165

PSIU:

116749060 116749147

PPHC:

136118688 136119371

NASI:

112397422 112397499

ECB:	100009712(CYP19A1)

EPZ:	103546924(CYP19A1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139003111(CYP19A1)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:	108388392(CYP19A1)

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138168496(CYP19A1)

MLAO:

141520085(CYP19A1)

OAA:

100078619

TACU:

119931561

GGA:	414854(CYP19A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137863068(CYP19A1)

OJA:

118171977

ACYG:

106033779(CYP19A1)

CATA:

118251648

AFUL:

116493626

TGU:	751777(CYP19A1)

LSR:	110474232(CYP19A1)

VMC:

128813446

VCHA:

128794741

AIB:	137481942(CYP19A1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139596872(CYP19A1)

MATE:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCW:

CBRC:

ACOE:

138116527(CYP19A1)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136366790(CYP19A1)

CFAI:

136296985(CYP19A1)

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

ANOC:

141965531(CYP19A1)

SURA:

141948221(CYP19A1)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

142038513(CYP19A1)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

IIN:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PARX:

142060316(CYP19A1)

PADL:

103922757

AFOR:

103896611

FGA:

104075899

CBOR:

142086454(CYP19A1)

GSTE:

104256103

CBOY:

140655716(CYP19A1)

MAME:

142411008(CYP19A1)

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

GAME:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

LMIC:

141748880(CYP19A1)

NARQ:

141470066(CYP19A1)

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102566432(CYP19A1)

CPOO:

109309026

GGN:

109288602

PSS:

102459111

CIZ:	142019863(CYP19A1)

CMY:

102946653

CCAY:

125644127

LKP:	140917948(CYP19A1)

NDS:	141994537(CYP19A1)

DCC:

CPIC:

TST:

EOB:

CABI:

MRV:

ACS:	100565397(cyp19a1)

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	373656(cyp19a1.L)

XTR:	100036594(cyp19a1)

NPR:

108799589

RTEM:

120931338

ACAT:

141131429(CYP19A1)

PADS:

140324472(CYP19A1)

BBUF:

120985817 120985818

BGAR:

122927630 122927631

DTC:	141084046(CYP19A1)

HSQ:

130368520

PWL:	138284072(CYP19A1)

MUO:

115461704

GSH:

117348369

DRE:	30390(cyp19a1a) 60640(cyp19a1b)

SRX:	107746936 107748317

SANH:

107674832 107700584

SGH:	107571340 107588541

CCAR:

109051432 109068452 109072133

CAUA:

113042873 113061867 113082814 113118576

CGIB:

127934323 127977536 128014519

PTET:

122330655 122362496

LROH:

127156350 127181253

GRF:	141312717(cyp19a1b) 141345669(cyp19a1a)

OMC:	131524768 131534839

PPRM:

120477771 120485850

RKG:	130089396 130106434

MAMB:

125246945 125254507

CIDE:

127500194 127507121

CERY:

137014956(cyp19a1b) 137023122(cyp19a1a)

MASI:

127436251 127456148

TROS:

130549838 130551793

TDW:	130413969 130435397

MANU:

129419642(cyp19a1a) 129433099 141362459

PDAB:

135746396(cyp19a1a) 135768264(cyp19a1b)

IPU:	100304581 108264511

IFU:	128607126 128618683

PHYP:

113530142 113534440

SMEO:

124392156 124395700

TFD:

113640941

TVC:	132851508 132856826

CGAR:

128514256 128527516

NGRA:

132881705 132888200

TRN:	134311698 134323481

AMEX:

103038449

CMAO:

118804009 118811907

EEE:	113577298 113584485

CHAR:

105889015 105892489

SPIL:

134094526 134096268

ASAD:

121682511

TRU:	100379639(pfcyp19b-tstr) 101076508(pfcyp19a)

TFS:	130514159 130535683

TNG:	GSTEN00018058G001 GSTEN00025591G001

LCO:	104920192 104932825

NCC:	104960111 104962728

TBEN:

117471655 117491915

CGOB:

115009664 115024369

PGEO:

117447765(cyp19a1a)

GACU:

117538803 117549393

EMAC:

134863227 134877208

ELY:	117258936 117261795

EFO:	125886862 125904127

PLEP:

121947240 121949866

SLUC:

116038508 116054646

ECRA:

117939964 117949645

ESP:	116691016 116693877

PFLV:

114557236 114559505

GAT:	120808695 120811580

PPUG:

119196278 119197603

AFB:	129105323 129108358

CLUM:

117732474 117750439

PSWI:

130194975

CANA:

137780749(cyp19a1a) 137804475(cyp19a1b)

CVE:	137880886(cyp19a1b) 137887323(cyp19a1a)

MSAM:

119890709 119893898

SCHU:

122875290 122875399

EARM:

139286223(cyp19a1b) 139301522(cyp19a1a)

CUD:	121515762 121524971

SPUL:

138612464(cyp19a1a) 138613552

LMIX:

132969488 132972607

HTC:	141787349(cyp19a1a) 141796991(cyp19a1b)

ALAT:

119017644 119023827

ASTR:

137593357(cyp19a1b) 137598600(cyp19a1a)

PKLU:

139201812(cyp19a1b) 139206382(cyp19a1a)

MZE:	101468629(cyp19a1a) 106675461 112431276 143412433 143419374 143419375 143419376

ONL:	100534396 100708217

OAU:	116311653 116326742

OLA:	100125815(cyp19b) 101174651

OML:	112152291 112161048

CSAI:

133444884 133456348

XMA:	102231498 102236527

XCO:	114142484 114159678

XHE:	116718071 116736226

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122835378 122841295

PPRL:

129369686 129370875

CVG:	107085369 107096869

CTUL:

119782422 119792512

GMU:	124867322 124881651

NFU:	107373024 107388638

KMR:	108230104 108250266

ALIM:

106521145 106530933 106536387

NWH:	119416354 119423009

AOCE:

111565746 111577263

EJA:	138205749(cyp19a1b) 138213181(cyp19a1a)

BFRE:

138625045(cyp19a1a) 138626514(cyp19a1b)

MCEP:

125005804 125014725

CSEM:

103378914 103380488

POV:	109624148 109624967

SSEN:

122772648 122776510

SSOE:

131459431 131469705

HHIP:

117754230 117762605 117778658

HSP:	118103743 118109472 118122615 124851147

PPLT:

128440846 128444440

SMAU:

118301847 118315259

LCF:	108876685 108887913

SDU:	111223187 111229564

SLAL:

111656853 111666923

XGL:	120793548 120794915

HCQ:	109507515 109525752

SSCV:

125967127(cyp19a1a) 125970121

SBIA:

133497695 133502032

PEE:	133399339 133402410

PTAO:

133467229 133478541

BPEC:

110169315 110172912

ENY:	140349578(cyp19a1b) 140380997(cyp19a1a)

MALB:

109963333 109974150

BSPL:

114852301 114857594

SJO:	128359247 128361936

SSCO:

133982238 133985088

TTY:	137179867(cyp19a1a) 137183159

GMH:	115550694 115558204

SASA:

106562534 106584746(CYP19B) 106587170(CYP19)

STRU:

115166948 115192897 115203363

OTW:	112241217 112264373

OMY:	110506809 110506810 110521201

OGO:	124017811 124037481

ONE:	115116861 115144680

OKI:	109895311 109897677

OKE:	118359379 118382159

OMM:	135533933 135556627 135556733

OCLA:

139399523 139403846 139403849 139403873 139406345

SALP:

112068480 112073830

SNH:	120048793 120048801 120052328

SFON:

129846769 129854897

CCLU:

121540733 121579689

ELS:	105018178 105022679

OEP:	134021585 134027730

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

CPUN:

140468958(cyp19a1a)

HOC:

132834197

SCAU:

119974448

LERI:

129712588

HAKA:

140718892(cyp19a1a)

PMRN:

116938464

BFO:	118411241 118413506

BBEL:

BCOO:

HSY:

CCLM:

Reference

PMID:2973313 (CYP19A1)

Authors

Harada N

Title

Cloning of a complete cDNA encoding human aromatase: immunochemical identification and sequence analysis.

Journal

Biochem Biophys Res Commun 156:725-32 (1988)
DOI:10.1016/S0006-291X(88)80903-3

Sequence

[hsa:1588]

LinkDB

ENZYME: 1.14.14.14

Entry

EC 1.14.14.14               Enzyme

Name

aromatase;
CYP19A1 (gene name);
estrogen synthetase (incorrect)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

testosteronel,NADPH---hemoprotein reductase:oxygen oxidoreductase (17beta-estradiol-forming)

Reaction(IUBMB)

(1) testosterone + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = 17beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH---hemoprotein reductase] (overall reaction) [RN:R10511];
(1a) testosterone + O2 + [reduced NADPH---hemoprotein reductase] = 19-hydroxytestosterone + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R02501];
(1b) 19-hydroxytestosterone + O2 + [reduced NADPH---hemoprotein reductase] = 19-oxotestosterone + 2 H2O + [oxidized NADPH---hemoprotein reductase] [RN:R04761];
(1c) 19-oxotestosterone + O2 + [reduced NADPH---hemoprotein reductase] = 17beta-estradiol + formate + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R03087];
(2) androst-4-ene-3,17-dione + 3 O2 + 3 [reduced NADPH---hemoprotein reductase] = estrone + formate + 4 H2O + 3 [oxidized NADPH---hemoprotein reductase] (overall reaction) [RN:R10515];
(2a) androst-4-ene-3,17-dione + O2 + [reduced NADPH---hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R01840];
(2b) 19-hydroxyandrost-4-ene-3,17-dione + O2 + [reduced NADPH---hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + 2 H2O + [oxidized NADPH---hemoprotein reductase] [RN:R04759];
(2c) 19-oxoandrost-4-ene-3,17-dione + O2 + [reduced NADPH---hemoprotein reductase] = estrone + formate + H2O + [oxidized NADPH---hemoprotein reductase] [RN:R02351]

Reaction(KEGG)

R01840 R02351 R02501 R03087 R04759 R04761 R10511 R10515

Substrate

testosterone [CPD:C00535];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
19-hydroxytestosterone [CPD:C05294];
19-oxotestosterone [CPD:C05295];
androst-4-ene-3,17-dione [CPD:C00280];
19-hydroxyandrost-4-ene-3,17-dione [CPD:C05290];
19-oxoandrost-4-ene-3,17-dione [CPD:C05297]

Product

17beta-estradiol;
formate [CPD:C00058];
H2O [CPD:C00001];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
19-hydroxytestosterone [CPD:C05294];
19-oxotestosterone [CPD:C05295];
estrone [CPD:C00468];
19-hydroxyandrost-4-ene-3,17-dione [CPD:C05290];
19-oxo-androst-4-ene-3,17-dione

Comment

A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17beta-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.

History

EC 1.14.14.14 created 2013

Pathway

ec00140

Steroid hormone biosynthesis

ec01100

Metabolic pathways

Orthology

K07434

aromatase

Genes

HSA:	1588(CYP19A1)

PTR:	453433(CYP19A1)

PPS:	100984744(CYP19A1)

GGO:

101137192

PON:

100439777

PPYG:

129014438

NLE:

100589061

HMH:

116481527

SSYN:

129482772

MCC:	678697(CYP19A1)

MCF:	102117886(CYP19A1)

MTHB:

126959039

MNI:

105490390

CSAB:

103245629(CYP19A1)

CATY:

105588232

PANU:

100997810 116272542

TGE:

112627390

MLEU:

105550746

RRO:

104656901

RBB:

108544828

TFN:

117070662

PTEH:

111552757

CANG:

105502210

CJC:	100411557(CYP19A1)

SBQ:

101051393

CIMI:

108286664(CYP19A1)

ANAN:

105710056(CYP19A1)

CSYR:

103274056

MMUR:

105870707

LCAT:

123622663

ERUF:

138376016(CYP19A1)

PCOQ:

105821381

OGA:

100950881

MMU:	13075(Cyp19a1)

MCAL:

110301208

MPAH:

110328587

RNO:	25147(Cyp19a1)

MCOC:

116073015

ANU:

117699489

ASYL:

127689937

MUN:

110549466

CGE:

100769024

MAUA:

101836523

PROB:

127231762

PLEU:

114690371

PMAV:

102926053(Cyp19a1)

MORG:

121438190

MFOT:

126486960

AAMP:

119810788

CNL:

130873733

NGI:

103731396

HGL:

101702005

CPOC:

100721069

CCAN:

109675669 109679172

DORD:

105981070

DSP:

122114579

DMER:

138809042(Cyp19a1)

PLOP:

125340435

NCAR:

124977775

MMMA:

107138103

ITI:

101954950

OCU:	100328545(CYP19A1)

OPI:

101518265

OCZ:

121148961

TUP:

102503106

GVR:

103597966

CFA:	494003(CYP19A1)

CLUD:

112675933

VVP:

112920063

VLG:

121484563

NPO:

129506221

AML:

100464417

UMR:

103676745

UAH:

113269623

UAR:

123801876

ELK:

111138628

LLV:

125105151

MPUF:

101687608

MNP:

131998732

MLK:

131836281

NVS:

122893076

ORO:

101383271

EJU:

114206510

ZCA:

113910201

MLX:

118003757

MANO:

123861211

NSU:

110583928

LWW:

102731614

FCA:	101094932(CYP19A1)

PYU:

121041697

PCOO:

112855925

PBG:

122468647

PVIV:

125169100

LRUF:

124508055

LGF:

123583023

AJU:

106967273

PTG:

102962141

PPAD:

109262992

PUC:

125909993

PLEZ:

122222039

HHV:

120234998

CCRU:

144231838(CYP19A1)

BTA:	281740(CYP19A1)

BOM:

102277416

BIU:

109565118

BBUB:

102392019

BKE:	129620598 129621471

BBIS:

104988240

CHX:	100861413(CYP19A1) 102172726

OAS:	100144423(CYP19)

BTAX:

128054322 128054328

CSUM:

138073095(CYP19A1)

ODA:	120852986 120853641

CCAD:

122443608

MREE:

136171828(CYP19A1) 136172629

OVR:	110122056(CYP19A1)

MBEZ:

129562964

SSC:	403331(CYP19A1) 403332(CYP19A2) 403333(CYP19A3)

CFR:	102519005 116664105

CBAI:

105067585

CDK:	105086637 105106135 116153434

VPC:

102526537

BACU:

103011787 103012080

BMUS:

118890681 118890682 118890683

LVE:	103080853 103081312

OOR:	101270659 101283540

LALB:

132531413 132531419

GMF:	132596756(CYP19A1) 132596757

DDP:	132419694(CYP19A1)

DLE:	111170860 111170861 111171015

PCAD:

102982383 102982657 102995165

PSIU:

116749060 116749147

PPHC:

136118688 136119371

NASI:

112397422 112397499

ECB:	100009712(CYP19A1)

EPZ:	103546924(CYP19A1)

EAI:

106838329

MYB:

102253564

MYD:

102753728

MMYO:

118664564

MLF:

102420943

MDT:

132219049

MYUM:

139003111(CYP19A1)

PKL:

118721269

EFUS:

103287429

MNA:

107546547

DRO:

112311730

SHON:

118992519

AJM:

119047586

PDIC:

114493114

PHAS:

123808544

MMF:

118640532

PPAM:

129063733

HAI:

109394298

RFQ:

117023688

PALE:

102884354

PGIG:

120623102

PVP:

105288748

RAY:

107519739

MJV:	108388392(CYP19A1)

TOD:

119238620

SARA:

101552379

SFUM:

130043104

SETR:

126015455

LAV:

100669426

TMU:

101350058

ETF:

101657950

DNM:

101411338

MDO:

100031295

GAS:

123234102

SHR:

100929873

AFZ:

127547116

PCW:

110207989

TVP:

118829296

PBRV:

138168496(CYP19A1)

MLAO:

141520085(CYP19A1)

OAA:

100078619

TACU:

119931561

GGA:	414854(CYP19A1)

PCOC:

116244696

MGP:

100549427

CJO:

107318718

TPAI:

128075313

LMUT:

125698403

NMEL:

110403699

APLA:

101791068

AACU:

137863068(CYP19A1)

OJA:

118171977

ACYG:

106033779(CYP19A1)

CATA:

118251648

AFUL:

116493626

TGU:	751777(CYP19A1)

LSR:	110474232(CYP19A1)

VMC:

128813446

VCHA:

128794741

AIB:	137481942(CYP19A1)

SCAN:

103816009

PMOA:

120508816

OTC:

121343497

PRUF:

121354453

ATRC:

139596872(CYP19A1)

MATE:

118690907

GFR:

102039345

FAB:

101821137

OMA:

130257251

PHI:

102100785

PMAJ:

117244929

CCW:

104684007

CBRC:

103621248

ACOE:

138116527(CYP19A1)

ETL:

114057141

ZAB:

102064981

ZLE:

135452040

ACHL:

103808252

SVG:

106851780

MMEA:

130575817

HRT:

120758590

SATI:

136366790(CYP19A1)

CFAI:

136296985(CYP19A1)

CCIC:

134049207

FPG:

101920378

FCH:

102056433

CCRI:

104155487

NNT:

104404179

SHAB:

115612630

ACUN:

113484084

ANOC:

141965531(CYP19A1)

SURA:

141948221(CYP19A1)

TALA:

104362311

ACHC:

115341655

HALD:

104317717

HLE:

104834489

AGEN:

126043912

HHAR:

128151168

BBUT:

142038513(CYP19A1)

GCL:

127020633

CSTI:

104550673

LDI:

104351247

MNB:

103772445

DPUB:

104297321

PPUS:

135182962

IIN:

128972144

AVIT:

104280735

BRHI:

104488415

EGZ:

104130907

NNI:

104017141

PCRI:

104038312

PCAO:

104042374

PARX:

142060316(CYP19A1)

PADL:

103922757

AFOR:

103896611

FGA:

104075899

CBOR:

142086454(CYP19A1)

GSTE:

104256103

CBOY:

140655716(CYP19A1)

MAME:

142411008(CYP19A1)

CLV:

102090413

CNIC:

135992623

MUI:

104536501

PGUU:

104459145

PLET:

104619051

EHS:

104503710

CMAC:

104474080

CUCA:

104054910

TEO:

104380156

BREG:

104630739

GAME:

129210935

OHA:

104334585

ACAR:

104519269

CPEA:

104385920

CVF:

104287055

RTD:

128914969

CRID:

134520604

LMIC:

141748880(CYP19A1)

NARQ:

141470066(CYP19A1)

AAM:

106496434

AROW:

112963461

NPD:

112952883

TGT:

104565160

DNE:

112981439

SCAM:

104148271

ASN:

102378511

AMJ:	102566432(CYP19A1)

CPOO:

109309026

GGN:

109288602

PSS:

102459111

CIZ:	142019863(CYP19A1)

CMY:

102946653

CCAY:

125644127

LKP:	140917948(CYP19A1)

NDS:	141994537(CYP19A1)

DCC:

119863027

CPIC:

101943325

TST:

117884452

EOB:

135884503

CABI:

116823795

MRV:

120373635

ACS:	100565397(cyp19a1)

ASAO:

132762372

PVT:

110077216

SUND:

121934532

PBI:

103056596

PMUR:

107300116

CTIG:

120315257

PGUT:

117674538

APRI:

131184543

PTEX:

113442239

NSS:

113418339

VKO:

123027699

PRAF:

128402012

ZVI:

118092454

HCG:

128335161

GJA:

107122388

STOW:

125424557

EMC:

129345447

XLA:	373656(cyp19a1.L)

XTR:	100036594(cyp19a1)

NPR:

108799589

RTEM:

120931338

ACAT:

141131429(CYP19A1)

PADS:

140324472(CYP19A1)

BBUF:

120985817 120985818

BGAR:

122927630 122927631

DTC:	141084046(CYP19A1)

HSQ:

130368520

PWL:	138284072(CYP19A1)

MUO:

115461704

GSH:

117348369

DRE:	30390(cyp19a1a) 60640(cyp19a1b)

SRX:	107746936 107748317

SANH:

107674832 107700584

SGH:	107571340 107588541

CCAR:

109051432 109068452 109072133

CAUA:

113042873 113061867 113082814 113118576

CGIB:

127934323 127977536 128014519

PTET:

122330655 122362496

LROH:

127156350 127181253

GRF:	141312717(cyp19a1b) 141345669(cyp19a1a)

OMC:	131524768 131534839

PPRM:

120477771 120485850

RKG:	130089396 130106434

MAMB:

125246945 125254507

CIDE:

127500194 127507121

CERY:

137014956(cyp19a1b) 137023122(cyp19a1a)

MASI:

127436251 127456148

TROS:

130549838 130551793

TDW:	130413969 130435397

MANU:

129419642(cyp19a1a) 129433099 141362459

PDAB:

135746396(cyp19a1a) 135768264(cyp19a1b)

IPU:	100304581 108264511

IFU:	128607126 128618683

PHYP:

113530142 113534440

SMEO:

124392156 124395700

TFD:

113640941

TVC:	132851508 132856826

CGAR:

128514256 128527516

NGRA:

132881705 132888200

TRN:	134311698 134323481

AMEX:

103038449

CMAO:

118804009 118811907

EEE:	113577298 113584485

CHAR:

105889015 105892489

SPIL:

134094526 134096268

ASAD:

121682511

TRU:	100379639(pfcyp19b-tstr) 101076508(pfcyp19a)

TFS:	130514159 130535683

TNG:	GSTEN00018058G001 GSTEN00025591G001

LCO:	104920192 104932825

NCC:	104960111 104962728

TBEN:

117471655 117491915

CGOB:

115009664 115024369

PGEO:

117447765(cyp19a1a)

GACU:

117538803 117549393

EMAC:

134863227 134877208

ELY:	117258936 117261795

EFO:	125886862 125904127

PLEP:

121947240 121949866

SLUC:

116038508 116054646

ECRA:

117939964 117949645

ESP:	116691016 116693877

PFLV:

114557236 114559505

GAT:	120808695 120811580

PPUG:

119196278 119197603

AFB:	129105323 129108358

CLUM:

117732474 117750439

PSWI:

130194975

CANA:

137780749(cyp19a1a) 137804475(cyp19a1b)

CVE:	137880886(cyp19a1b) 137887323(cyp19a1a)

MSAM:

119890709 119893898

SCHU:

122875290 122875399

EARM:

139286223(cyp19a1b) 139301522(cyp19a1a)

CUD:	121515762 121524971

SPUL:

138612464(cyp19a1a) 138613552

LMIX:

132969488 132972607

HTC:	141787349(cyp19a1a) 141796991(cyp19a1b)

ALAT:

119017644 119023827

ASTR:

137593357(cyp19a1b) 137598600(cyp19a1a)

PKLU:

139201812(cyp19a1b) 139206382(cyp19a1a)

MZE:	101468629(cyp19a1a) 106675461 112431276 143412433 143419374 143419375 143419376

ONL:	100534396 100708217

OAU:	116311653 116326742

OLA:	100125815(cyp19b) 101174651

OML:	112152291 112161048

CSAI:

133444884 133456348

XMA:	102231498 102236527

XCO:	114142484 114159678

XHE:	116718071 116736226

PRET:

103462065 103466459

PFOR:

103143597 103156494

PLAI:

106947725 106960953

PMEI:

106912224 106932411

GAF:	122835378 122841295

PPRL:

129369686 129370875

CVG:	107085369 107096869

CTUL:

119782422 119792512

GMU:	124867322 124881651

NFU:	107373024 107388638

KMR:	108230104 108250266

ALIM:

106521145 106530933 106536387

NWH:	119416354 119423009

AOCE:

111565746 111577263

EJA:	138205749(cyp19a1b) 138213181(cyp19a1a)

BFRE:

138625045(cyp19a1a) 138626514(cyp19a1b)

MCEP:

125005804 125014725

CSEM:

103378914 103380488

POV:	109624148 109624967

SSEN:

122772648 122776510

SSOE:

131459431 131469705

HHIP:

117754230 117762605 117778658

HSP:	118103743 118109472 118122615 124851147

PPLT:

128440846 128444440

SMAU:

118301847 118315259

LCF:	108876685 108887913

SDU:	111223187 111229564

SLAL:

111656853 111666923

XGL:	120793548 120794915

HCQ:	109507515 109525752

SSCV:

125967127(cyp19a1a) 125970121

SBIA:

133497695 133502032

PEE:	133399339 133402410

PTAO:

133467229 133478541

BPEC:

110169315 110172912

ENY:	140349578(cyp19a1b) 140380997(cyp19a1a)

MALB:

109963333 109974150

BSPL:

114852301 114857594

SJO:	128359247 128361936

SSCO:

133982238 133985088

TTY:	137179867(cyp19a1a) 137183159

GMH:	115550694 115558204

SASA:

106562534 106584746(CYP19B) 106587170(CYP19)

STRU:

115166948 115192897 115203363

OTW:	112241217 112264373

OMY:	110506809 110506810 110521201

OGO:	124017811 124037481

ONE:	115116861 115144680

OKI:	109895311 109897677

OKE:	118359379 118382159

OMM:	135533933 135556627 135556733

OCLA:

139399523 139403846 139403849 139403873 139406345

SALP:

112068480 112073830

SNH:	120048793 120048801 120052328

SFON:

129846769 129854897

CCLU:

121540733 121579689

ELS:	105018178 105022679

OEP:	134021585 134027730

SFM:

108942040

PKI:

111846707

AANG:

118215725

AROT:

135242325

CCOG:

133112139

LOC:

102685592

PSPA:

121294903 121299384

ARUT:

117428169 117429562

PSEX:

120539946

LCM:

102348763

CMK:

103186779

RTP:

109931474

CPLA:

122540976

CPUN:

140468958(cyp19a1a)

HOC:

132834197

SCAU:

119974448

LERI:

129712588

HAKA:

140718892(cyp19a1a)

PMRN:

116938464

BFO:	118411241 118413506

BBEL:

109471188 109481437

BCOO:

119082474

HSY:

130613325

CCLM:

134186942

» show all

Reference

1 [PMID:4370479]

Authors

Thompson EA Jr, Siiteri PK

Title

The involvement of human placental microsomal cytochrome P-450 in aromatization.

Journal

J Biol Chem 249:5373-8 (1974)

Reference

2 [PMID:7217091]

Authors

Fishman J, Goto J

Title

Mechanism of estrogen biosynthesis. Participation of multiple enzyme sites in placental aromatase hydroxylations.

Journal

J Biol Chem 256:4466-71 (1981)

Reference

3 [PMID:3104339]

Authors

Kellis JT Jr, Vickery LE

Title

Purification and characterization of human placental aromatase cytochrome P-450.

Journal

J Biol Chem 262:4413-20 (1987)

Reference

4 [PMID:19129847]

Authors

Ghosh D, Griswold J, Erman M, Pangborn W

Title

Structural basis for androgen specificity and oestrogen synthesis in human aromatase.

Journal

Nature 457:219-23 (2009)
DOI:10.1038/nature07614

Sequence

[hsa:1588]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.14

IUBMB Enzyme Nomenclature:

1.14.14.14

ExPASy - ENZYME nomenclature database:

1.14.14.14

BRENDA, the Enzyme Database:

1.14.14.14

LinkDB

REACTION: R03087

Entry

R03087                      Reaction

Name

19-oxotestosterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)

Definition

19-Oxotestosterone + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estradiol-17beta + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O

Equation

C05295 + C00007 + C03024 <=> C00951 + C00058 + C03161 + C00001

Comment

aromatase, ARO
following after R04761

Reaction class

RC02649

C00951_C05295

Enzyme

1.14.14.14

Pathway

rn00140

Steroid hormone biosynthesis

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14
     R03087  19-Oxotestosterone + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> Estradiol-17beta + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O

Orthology

K07434

aromatase [EC:1.14.14.14]

Other DBs

RHEA:

38190

LinkDB

DBGET integrated database retrieval system